替莫唑胺治疗复发脑胶质瘤效果分析

替莫唑胺治疗复发脑胶质瘤效果分析
吕冬芳;王雪笠;武江;岳向勇
【期刊名称】《临床误诊误治》
【年(卷),期】2014(000)009
【摘要】目的：探讨替莫唑胺( Temozolomide, TMZ)治疗复发脑胶质瘤的临床
效果与安全性。

方法选择复发脑胶质瘤42例口服TMZ起始剂量150
mg/( m2·d),连服5 d,28 d为1个周期。

治疗3个周期后观察临床效果与不良反应情况。

结果本组42例均顺利完成化疗,期间无1例出现治疗相关性死亡。

本组15例肿瘤明显缩小,部分缓解(PR)率为35.7%(15/42)；16例肿瘤稳定,疾病稳定(SD)率为38.1%(16/42)；11例肿瘤增大,进展(PD)率为26.2%(11/42)。

有效率(CR+PR)为35.7%(15/42),疾病控制率(CR+PR+SD)为73.8%(31/42)。

本组21
例出现恶心、呕吐症状,6例出现白细胞、中性粒细胞、血小板降低等毒性反应,2
例出现不同程度脱发,但均未发生肝、肾、肺等其他重要脏器损的害。

结论 TMZ对复发脑胶质瘤具有一定的临床效果,其不良反应少,是较理想的化疗用
药。

%Objective To evaluate the efficacy and safety of temozolomide ( TMZ) in the treatment of recurrent brain gliomas. Methods A total of 42 patients with recurrent brain glioma were treated by TMZ with a initial dosage of 150 mg/m2 once a day for durative 5 days and 28 days as a treatment cycle. The clinical curative effect and complications were observed after 3 cycles of treatment. Results The group of 42 patients was successfully completed chemotherapy, and no treatment-re-lated death occurred during the therapy. There were 15 patients with reduced tumor sizes, and
the partial remission ( PR) rate was 35.7% (15/42); 16 patients with stable diseases, and the stable disease (stable disease, SD) rate was 38.
1%(16/42);11 patients with tumor growth, and the progression (progressive disease, PD) rate was 26. 2% (11/42). Efficien-cy rate (CR+PR) in the group was 35. 7% (15/42), and disease control rate (CR+PR+SD) was 73. 8% (31/42). Twenty-one patients had nausea and vomiting, and six patients had toxic reactions, such as decreased white blood cells, neu-trophils, and platelets. Two patients showed different degrees of hair loss, but no damage of liver, kidney, and lung. Conclu-sion TMZ is an ideal chemotherapy drug that can be used to treat recurrent brain glioma, because it has a certain clinical effect and less adverse reaction.
【总页数】3页(P99-101)
【作者】吕冬芳;王雪笠;武江;岳向勇
【作者单位】050082 石家庄，解放军白求恩国际和平医院神经内科;050082 石家庄，解放军白求恩国际和平医院神经内科;050051 石家庄，河北省人民医院功能神经外科;050051 石家庄，河北省人民医院功能神经外科
【正文语种】中文
【中图分类】R730.264
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