mean platelet volume 血小板平均体积
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ORs were calculated from the effect estimates of the individual studies, using both a fixed effects model and a random-effects model
The First Affiliated Hospital SUMC
Literature search and study selection
flow chart
The First Affiliated Hospital SUMC
Materials and methods
Data extraction
1)lead author, 2)publication year, 3)Study population, 4)sex, 5)Mean age, 6)Numbers of AMI cases and non-AMI controls, 7)Numbers of restenosis cases and norestenosis controls, 8)study design, MPV assay methods, 9)For cohort studies, follow-up time and primary endpoints.
The First Affiliated Hospital SUMC
Materials and methods
Literature search and study selection
flow chart
The First Affiliated Hospital SUMC
Materials and methods
The First Affiliated Hospital SUMC
Matysis
Cross-sectional studies, the primary summary measure of association was the overall random-effects mean difference in MPV between cases and controls. prospective cohort studies, summary odds ratios (ORs) and 95% CIs were used to measure the association between MPV and incident mortality.
Results
The First Affiliated Hospital SUMC
MPV and MI
Results
Random-effects pooled mean difference of MPV between AMI and non-AMI
The mean MPV in all 16 studies was 8.95 fL(95% CI 8.49–9.41).
Meta-analysis
The First Affiliated Hospital SUMC
Aim
The emphasis of this article is to detail:
(i) whether there exists an association between MPV and AMI ; (ii) whether elevatedMPV is associated with all-cause mortality following a MI; (iii) whether MPV is associated with restenosis following PCI.
The First Affiliated Hospital SUMC
MPV and risk of restenosis
In four of the five studies, restenosis was defined as > 50% diameter narrowing ; In the remaining study, reocclusion defined by TIMI flow grade 0 or 1. Among the 430 subjects who underwent a PCI, 176 (40.9%)developed restenosis.
MPV and risk of death following AMI
Results
Random-effects pooled OR of MPV and mortality following MI from prospective studies
No significant publication bias was detected among these studies
Materials and methods
Statistical analysis
Heterogeneity among studies using I2 statistics.
When p < 0.05, the presence of heterogeneity was considered to be statistically significant, and when I2 > 50%, the magnitude of heterogeneity was considered to be substantial.
the estimated mean level of baseline MPV was 8.29 fL (95% CI 8.05–8.53). Baseline mean MPV was significantly higher in patients who developed restenosis (8.67 fL, 95% CI 8.44–8.87) than in those who did not develop restenosis (7.96 fL, 95% CI 7.80–8.13). The estimated mean difference was 0.98 fL (95% CI 0.74–1.21, P < 0.001)
The First Affiliated Hospital SUMC
Platelet -MPV
Measuring platelet activity, it remains a research tool that is yet to be included in routine clinical decision making. MPV, the most commonly used measure of platelet size, is a potential marker of platelet reactivity.
MPV
Mean platelet volume as a predictor of cardiovascular risk
徐 坦
The First Affiliated Hospital SUMC
Platelet
Platelets play a pivotal role in atherothrombosis, the major cause of most unstable coronary syndromes; Platelets secrete and express a large number of substances that are crucial mediators of coagulation, inflammation, thrombosis, and atherosclerosis;
The First Affiliated Hospital SUMC
Materials and methods
Literature search and study selection
systematic searches of the scientific literature:
cardiovascular disease and MPV
cardiovascular disease, coronary heart disease, myocardial infarction, percutaneous coronary intervention, mean platelet volume
MEDLINE database
January 1950 to September 2008, hand-searching references of original articles review articles on this topic and by personal contact with investigators.
Results
The First Affiliated Hospital SUMC
MPV and risk of restenosis
Results
Random-effects pooled mean difference of MPV between restenosis cases and no restenosis controls.
The First Affiliated Hospital SUMC
Materials and methods
Statistical analysis
Funnel plots of effect size against standard error (SE) and a modified linear regression test were used to describe the presence of publication bias.
The First Affiliated Hospital SUMC
MPV and risk of death following AMI
Results
In three cohort studies, 3184 patients with AMI
The First Affiliated Hospital SUMC
The First Affiliated Hospital SUMC
MPV
Larger platelets are metabolically and enzymatically more active , and have greater prothombotic potential.
The First Affiliated Hospital SUMC
The MPV was higher in patients with AMI (9.24 fL, 95% CI 8.39–10.08) than in those without AMI (8.48 fL, 95% CI 7.77–9.19). The estimated mean difference in MPV was 0.92 fL (95% CI 0.67–1.16).
A lack of heterogeneity does not necessarily imply homogeneity.
a summary OR was calculated, using a random-effects model, from the ORs and 95% CIs for each endpoint in each study.
The First Affiliated Hospital SUMC
MPV and MI
Sixteen cross-sectional studies involving 2809 subjects MPV, measured at the time of diagnosis
The non-AMI group included patients with unstable angina (7 studies), with stable coronary artery disease (7 studies), without coronary disease (12 studies).
The First Affiliated Hospital SUMC
Literature search and study selection
flow chart
The First Affiliated Hospital SUMC
Materials and methods
Data extraction
1)lead author, 2)publication year, 3)Study population, 4)sex, 5)Mean age, 6)Numbers of AMI cases and non-AMI controls, 7)Numbers of restenosis cases and norestenosis controls, 8)study design, MPV assay methods, 9)For cohort studies, follow-up time and primary endpoints.
The First Affiliated Hospital SUMC
Materials and methods
Literature search and study selection
flow chart
The First Affiliated Hospital SUMC
Materials and methods
The First Affiliated Hospital SUMC
Matysis
Cross-sectional studies, the primary summary measure of association was the overall random-effects mean difference in MPV between cases and controls. prospective cohort studies, summary odds ratios (ORs) and 95% CIs were used to measure the association between MPV and incident mortality.
Results
The First Affiliated Hospital SUMC
MPV and MI
Results
Random-effects pooled mean difference of MPV between AMI and non-AMI
The mean MPV in all 16 studies was 8.95 fL(95% CI 8.49–9.41).
Meta-analysis
The First Affiliated Hospital SUMC
Aim
The emphasis of this article is to detail:
(i) whether there exists an association between MPV and AMI ; (ii) whether elevatedMPV is associated with all-cause mortality following a MI; (iii) whether MPV is associated with restenosis following PCI.
The First Affiliated Hospital SUMC
MPV and risk of restenosis
In four of the five studies, restenosis was defined as > 50% diameter narrowing ; In the remaining study, reocclusion defined by TIMI flow grade 0 or 1. Among the 430 subjects who underwent a PCI, 176 (40.9%)developed restenosis.
MPV and risk of death following AMI
Results
Random-effects pooled OR of MPV and mortality following MI from prospective studies
No significant publication bias was detected among these studies
Materials and methods
Statistical analysis
Heterogeneity among studies using I2 statistics.
When p < 0.05, the presence of heterogeneity was considered to be statistically significant, and when I2 > 50%, the magnitude of heterogeneity was considered to be substantial.
the estimated mean level of baseline MPV was 8.29 fL (95% CI 8.05–8.53). Baseline mean MPV was significantly higher in patients who developed restenosis (8.67 fL, 95% CI 8.44–8.87) than in those who did not develop restenosis (7.96 fL, 95% CI 7.80–8.13). The estimated mean difference was 0.98 fL (95% CI 0.74–1.21, P < 0.001)
The First Affiliated Hospital SUMC
Platelet -MPV
Measuring platelet activity, it remains a research tool that is yet to be included in routine clinical decision making. MPV, the most commonly used measure of platelet size, is a potential marker of platelet reactivity.
MPV
Mean platelet volume as a predictor of cardiovascular risk
徐 坦
The First Affiliated Hospital SUMC
Platelet
Platelets play a pivotal role in atherothrombosis, the major cause of most unstable coronary syndromes; Platelets secrete and express a large number of substances that are crucial mediators of coagulation, inflammation, thrombosis, and atherosclerosis;
The First Affiliated Hospital SUMC
Materials and methods
Literature search and study selection
systematic searches of the scientific literature:
cardiovascular disease and MPV
cardiovascular disease, coronary heart disease, myocardial infarction, percutaneous coronary intervention, mean platelet volume
MEDLINE database
January 1950 to September 2008, hand-searching references of original articles review articles on this topic and by personal contact with investigators.
Results
The First Affiliated Hospital SUMC
MPV and risk of restenosis
Results
Random-effects pooled mean difference of MPV between restenosis cases and no restenosis controls.
The First Affiliated Hospital SUMC
Materials and methods
Statistical analysis
Funnel plots of effect size against standard error (SE) and a modified linear regression test were used to describe the presence of publication bias.
The First Affiliated Hospital SUMC
MPV and risk of death following AMI
Results
In three cohort studies, 3184 patients with AMI
The First Affiliated Hospital SUMC
The First Affiliated Hospital SUMC
MPV
Larger platelets are metabolically and enzymatically more active , and have greater prothombotic potential.
The First Affiliated Hospital SUMC
The MPV was higher in patients with AMI (9.24 fL, 95% CI 8.39–10.08) than in those without AMI (8.48 fL, 95% CI 7.77–9.19). The estimated mean difference in MPV was 0.92 fL (95% CI 0.67–1.16).
A lack of heterogeneity does not necessarily imply homogeneity.
a summary OR was calculated, using a random-effects model, from the ORs and 95% CIs for each endpoint in each study.
The First Affiliated Hospital SUMC
MPV and MI
Sixteen cross-sectional studies involving 2809 subjects MPV, measured at the time of diagnosis
The non-AMI group included patients with unstable angina (7 studies), with stable coronary artery disease (7 studies), without coronary disease (12 studies).