富血小板血浆修复膝关节骨关节炎

富血小板血浆修复膝关节骨关节炎
吴骁;檀亚军;咸杰;何本祥
【期刊名称】《中国组织工程研究》
【年(卷),期】2016(020)042
【摘要】背景：富血小板血浆因含有大量血小板源性生长因子对膝骨性关节炎有较好的疗效，但目前对关节面软骨的修复效果尚有争议。

<br> 目的：观察富血小板血浆对兔膝骨关节炎模型的关节软骨修复作用。

<br> 方法：采用Hulth法建立右膝骨关节炎兔模型，分别于右膝关节腔灌注富血小板血浆和玻璃酸钠，并设置模型组和假手术组作对比。

造模后8周，测定各组兔关节滑液中一氧化氮水平，观察关节面形态及软骨修复情况。

<br> 结果与结论：①关节面软骨形态比较：富血小板血浆治疗组关节面损伤修复情况明显好于其他3组；②富血小板血浆治疗组软骨组织Mankin’s评分和关节液中一氧化氮水平均低于模型组和玻璃酸钠治疗组(P<0.05)，高于假手术组(P<0.05)；③结果说明：膝关节腔灌注富血小板血浆对兔膝骨关节炎模型的关节软骨修复效果较好，效果优于玻璃酸钠灌注。

%BACKGROUND:Platelet-rich plasma (PRP) containing high levels of platelet-derived growth factor for knee osteoarthritis has achieved good clinical results;however, the effects of RPR on the repair of damaged articular cartilage are stil controversial. <br> OBJECTIVE:To study the effects of RPR on the repair of damaged articular cartilage in a rabbit model of knee osteoarthritis. <br> METHODS:The model of osteoarthritis in the rabbit right knee was established by Hulth’s method. Autologous PRP (0.5 mL) (PRP group), sodium hyaluronate (0.5 mL) (sodium
hyaluronate group), and normal saline (model group) were injected into the right knee joint cavity, respectively. The morphology of articular surface and nitric oxide contents in knee joint fluid were observed and determined at 8 weeks after surgery. <br> RESULTS AND CONCLUSION:The morphology of articular cartilage in the PRP group was better than that in the other three groups. Mankin scores of articular cartilage and nitric oxide contents of knee joint fluid in the PRP group were significantly decreased compared with the model and sodium hyaluronate groups that in (P<0.05), while increased compared with the sham-operation group (P<0.05). Our results suggest that repair effects of PRP on the damaged articular cartilage are superior to sodium hyaluronate treatment.
【总页数】6页(P6259-6264)
【作者】吴骁;檀亚军;咸杰;何本祥
【作者单位】成都体育学院，四川省成都市 610041;成都体育学院，四川省成都市 610041;成都体育学院，四川省成都市 610041;成都体育学院，四川省成都市610041
【正文语种】中文
【中图分类】R318
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