2011年第十三届中国科协年会-中国药理学会

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中国药理学会2010年新春联谊会在京圆满召开

展形式申办新的学术期刊和科普杂志，扩大学术交流范围。加强现有期刊杂志的发展和提．鼓
高工作，积极支持期刊杂志健康发展。
６．在科协的领导下，完成科协相关项目，开展相关学术活动；结合国家发展和建设需求，创新性的开展工作；加强学会网站建设，完善与会员交流的平台。
圆满结束。
学会领导及专家教授合影
联谊会大厅
７
中国药理通讯２１第二十七卷第一期００年
的共同努力下，把药理学会的工作做得更好。
七、中国药理学会２１年工作重点００
１一步加强学会建设和学会改革，积极发展会员，促进学会发展，把学会建设成为和谐．进的会员之家，促进药理学事业发展。
中国药理学会２１００年新春联谊会在京圆满召开
中国药理学会办公室穆鑫
中国药理学会２１００年新春联谊会于２１００年１月２日在北京前门建国酒店隆重召开。会议４
邀请了有关上级部门领导、外地常务理事、在京及近京学会理事以及学会工作骨干共约１０余名７代表参加会议。中国药理学会理事长杜冠华教授首先代表学会致辞，对各位代表的到来表示热烈欢迎。随后中国药理学会秘书长张永祥教授对学会２００９年的工作进行了总结报告。会议气氛热烈，欢快祥和，与会的学会代表畅所欲言，互相增进了了解。会上，我会会员代表还为大家表演了合唱、舞蹈、小提琴独奏等精彩的文艺节目，２１学会新春联谊会在一片欢歌笑语中００年

北京药理学会第二届理事会第一次全体会议纪要

北京药理学会第二届理事会第一次全体会议纪要
佚名
【期刊名称】《中国药理通讯》
【年(卷),期】2013(000)001
【摘要】2012年12月8日下午，北京药理学会第二届理事会第一次全体会议在北京中国科技会堂B209常委会议室召开。

本次会议的议题为选举第二届理事会常务理事及领导班子，商讨学会未来的工作计划。

选举工作由张永祥理事主持，陈乃宏理事担任总监票人。

19位常务理事候选人均超过2／3得票率顺利当选。

李林
理事当选为第二届理事会理事长，崔一民理事、孙建宁理事、王晓良理事、张兰理事、张永祥理事、朱晓新理事当选为副理事长，张兰理事兼任秘书长。

【总页数】2页(P43-44)
【正文语种】中文
【中图分类】R96
【相关文献】
1.中国药理学会第九届理事会第二次全体会议纪要 [J], 穆鑫
2.广东省蚕学会第九次会员代表大会暨第九届理事会第一次全体会议纪要 [J], 王先燕;邱国祥
3.江苏省外国文学学会第七届理事会第一次全体会议纪要 [J], 无
4.中国金属学会冶金技术经济学会第五届年会暨第二届理事会第一次会议纪要 [J],
5.全国化工高教学会第二届第三次全体理事会学术年会暨第三届第一次常务理事会会议纪要 [J],
因版权原因，仅展示原文概要，查看原文内容请购买。

中国药理学会第六届会员代表大会新一届理事会成立

中国药理学会第六届会员代表大会新一届理事会成立
佚名
【期刊名称】《四川生理科学杂志》
【年(卷),期】1993(000)0Z1
【摘要】中国药理学会第六届会员代表大会经过一年多的筹备工作,已于本年5月15—18日在北京召开。

我会代表来自全国各省市共约四百余人。

经过各省市蕴酿提名,在本届代表会上无记名选举产生了第六届理事会。

我省会员当选为理事的有王浴生、包定元、胡友梅,薛春生、王一涛、黄衡同志。

王浴生与包定元教授还当选为常务理事。

【总页数】1页(P35-35)
【正文语种】中文
【中图分类】R33
【相关文献】
1.中国畜牧兽医学会期刊编辑学分会召开第六届会员代表大会《中国乳业》杂志社社长冯艳秋当选为新一届理事会理事长 [J], 聂迎利
2.中设协新一届理事会诞生中国勘察设计协会第六届会员代表大会暨六届一次理事会议在京召开 [J],
3.贯彻落实科学发展观,积极推进保险理论研究,深入开展保险知识宣传上海市保险学会积极为上海保险市场又好又快发展作贡献——上海市保险学会召开第七届会员大会,选举产生新一届理事会,孙国栋当选名誉会长,张俊才任新一届理事会会长,潘涨潮任理事会秘书处秘书长 [J], 梁慧萱
4.中国电子商会第六届会员代表大会暨全体理事会在京召开王宁先生高票当选中国
电子商会新一届会长 [J], 黄雪怡;赵江涛
5.云南省水力发电工程学会第六次代表大会选举学会新一届理事会和学会六届一次理事会选举新一届常务理事会和学会领导人选举结果 [J],
因版权原因，仅展示原文概要，查看原文内容请购买。

庆祝北京药理学会、北京生理科学会2011年度学术会议在京召开

步对来年的工作进行了展望。在此之后，来自不同高校或研究机构，不同学科的四位学者进行
了精彩的学术报告。报告中各位学者对各自的研究领域内的专题进行了细致深入的介绍，而在座的研究同行也积极参与互动，针对报告中的问题展开讨论并提出合理的建议或展望。会议气氛热烈，学术报告取得了圆满成功。
天然产物的化合物，其发现与改造则是有效的天然药物研发的关键。孙博士的介绍正如其标题
所提示的为创新药物的研发提供了新的思路。
最后，解放军总医院临床药理研究室副研究员蔡芸介绍了治疗多药耐药鲍曼不动杆菌药物
研究的最新进展。鲍曼不动杆菌的多药耐药在今年的临床上处于不断恶化的趋势，而能够对抗
会副理事长李学军教授等专家学者出席会议。此外，来自北京多所高校和研究机构的青年科学
工作者也积极参与了会议。会议首先由北京药理学会理事长李林教授介绍北京药理学会在２１的工作情况，总结了０１年
一
年中学会组织的学术和实践活动以及活动中取得的可喜成绩。在此基础上，李林教授也进一
在上午的学术汇报之后，会议在下午又进行了青年论文报告会和优秀论文评比活动。在报
告会上，３位来自不同高校和研究机构的青年科研学者展示了各自在不同研究领域的科研成果。８多位专家对报告进行评价和提问，并从中选出１优秀论文。虽然每位报告者仅有８分钟时间６份介绍自己的工作成果，但多学科、多方面、多样性是这个报告会的特点，在座的报告人以及听

中国药理学会2011年新春联谊会在京圆满召开

中国药理学会２１年新春联谊会在京圆满召开０１
中国药理学会办公室穆鑫
中国药理学会２１０１年新春联谊会于２１年１１０１月６日在北京金辇酒店隆重召开。会议邀请
了有关上级部门领导、外地常务理事、在京及近京学会理事以及学会工作骨干共约２００余名代
药理学会２１年学术年会筹备隋况。常务理事们发言踊跃，讨论热烈，大家就如何凝聚力量、吸收更０１
１Ｏ
顺利召开，来自全省各地２Ｏ余位常务理事参加了会议，荣誉理事老专家马传庚教授、刘青云教
授、戴俐明教授等应邀参加了会议。安徽省科协副主席王海彦、学会部部长魏军锋和副部长田万龙到会祝贺，安徽医科大学党委书记李俊教授会议期问发来贺电，并送上新春祝福。安徽省药理学会理事长魏伟教授主持会议，本次会议的主要议题有三个：一是安徽省药理学会党组织和党员深入开展创先争优活动；二是讨论安徽省药理学会 “ 十二五”发展规划；三是讨论安徽省
２１年ｌ月１００１６日，１名国内优秀的青年药理学工作者获中国药理学会ＳＲＩＲ青年药２ＥＶＥ
理学工作者奖。
２１００年１２月１４日，我会理事长杜冠华教授，副理事长杨宝峰院士、苏定冯教授获得 “ 全国优秀科技工作者 ”称号，其中杨宝峰院士还获得 “ 十佳全国优秀科技工作者 ”称号。
表参加会议。中国药理学会理事长杜冠华教授首先代表学会致辞，对各位代表的到来表示热烈欢迎。随后中国药理学会秘书长张永祥教授对学会２１的工作进行了总结报告。会议气氛热００年

中国药理学会关于修改章程的报告

制药公司、阿斯特拉制药公司、拜耳制药公司等国内外企业积极资助了第十五届世界药理学大会。此外，４２名理事和广东省药理学会也以不同方式向大会提供了资助。２０年我会与健特药业有限公司合作完成了脑白金和黄金血康两项临床研究：０５脑白金是市场上影响广泛的保健品，对该产品的实际作用和安全性缺乏必要的科学研究，为了给社会提供科学的参考资料，中国药理学会主持脑白金的临床研究工作，中国医设立若干分会（原专业委员会）名称为中国药理学会。其
ＸＸＸ分会。分会实行委员制，不另定章程。其主任委员、副主任委员和委员经民主协商，推荐选举产生。全国各省、自治区、直辖市等地方药理学会称各地方药理学会。各地方药理学会名称按国家民政机构的规定冠名并自定章程，业务上接受本会指导。
学和相关学科工作者，可申请作为本会的资深会员。经常务理事会同意，并在一次性交纳规定会费后，成为资深会员，发给资深会员证，并终身保持；五、凡在药理及相关领域学术上有较高成就的港、澳、台药理学家或相关学科科学家，热心
中国药理学会章程（修改稿）
（０７９月１２０年４日中国药理学会八届六次常务理事会通过）
第一章总则
第一条中国药理学会（以下简称本会）是中华人民共和国民政部批准的社团法人，是中国
药理学科技工作者自愿结成依法登记成立的、具有公益性的全国性社会学术团体。会是中国科本
支持本会工作，符合本会会员条件，承认会章者可申请为本会会员。

关于开展2011年度国家科技奖励项目推荐工作的通知

５
中国药理通讯２１００年第二十七卷第四期
行的科普图书、科普电子出版物及音像制品。
（三）以下项目不得推荐
１．凡存在知识产权以及有关完成单位、完成人员等方面争议并正处于诉讼、仲裁或行政裁
决、行政复议程序中的，在争议未解决前不推荐。２．法律、行政法规规定必须取得有关许可证的，如动植物新品种、食品、药品、基因工程
中国药理通讯２１００年第二十七卷第四期
惊悉宋振玉教授不幸逝世，杜冠华理事长代表中国药理学会发去唁电，向宋教授的家属表
示亲切的慰问。
、 ቤተ መጻሕፍቲ ባይዱ
、
会通知
关于开展２１年度国家科技奖励项目推荐工作的通知０１
中国药理学会办公室
１．国家自然科学奖候选人必须是代表性论文或专著的作者，提交的论文或专著不超过８，仅限篇
国内立项的科学研究成果，应于２０年２２０８月８日以前在国内外公开发行的刊物上发表或出版。
２．国家技术发明奖项目要求主要技术发明点应在２００８年２月２８日以前已正式应用，需提供旁证材料支持，不得提交未授权知识产权证明材料。
科协网站（ｔ：／ｗｗ．ａｔｒ．ｎｈｔ／ｗｃｓｏｇｃ）表彰奖励栏目下载２１年度国家科技奖励各奖种推荐ｐ．０１
书（ｒ）及填写要求等。ｗｏｄ版２．项目简要情况表（附件１０套。见）２３．国家科技进步奖科普类项目还需附４套科普作品。

药理学发展简史(优.选)

药理学发展简史学院(系) 中药系班级 11级药材班学号 11406016姓名王鹏指导老师于海食完成时间 2013年10月2日摘要：药理学（pharmacology）是研究药物和机体相互作用及其规律的一门学科。

其内容包括药物药物效应动力学（pharmacodynamics）和药物代谢动力学（pharmacokinetics）。

这门学科经历了药物学阶段和现代药理学阶段，两个阶段的发展和完善才形成一门现代科学。

而中国在药理学的发展付出巨大的贡献，本文将重点论述中国在世界药理学发展历史所起到的作用和中国药理学的发展过程。

关键词：药理学发展历史药物学现代药理学中国前言药理学一直伴随着人类历史的发展而发展，数学、物理学、化学和生物学等基础科学是药理学发展的支柱，相关历史事件众多。

已有文献根据认识规律对药理学的发展进行过简要阐释，但未提出合理的发展阶段。

现行的药理学教科书中在绪论中对药理学的发展进行了简要介绍，但多以时间为线索罗列药理学甚至生物医学的主要历史事件，未能对这些历史事件进行有线索地归纳，也未提出合理的发展阶段，甚至将药理学事件和基础科学发展事件不加区分地列在一起。

因此，笔者将药理学发展归为两个阶段，药物学阶段和现代药理学阶段。

药理学发展简史药理学是研究药物和机体相互作用的一门科学。

[1]它阐明了药物防治疾病的基本规律性，从而为临床合理用药提供基本理论。

其中本学科的发展分为药物学阶段和现代药理学阶段两个阶段，中国在这两个阶段的发展中都付出了巨大贡献。

一．最初发展阶段：药物学众所周知，药理学是基于古代的药物学或者称本草学的基础上发展开来的[2]。

最早的药理学源于对“火”与“酒”的认识和利用。

古代，原始人的生活环境十分差。

为了生存必须猎取食物，当时主要食物来源是渔猎动物和采摘植物。

最初并不知道哪些可食哪些有毒，难免遇到致吐、腹泻、发汗、止痛、止血等情况，甚至也会有中毒死亡的情况发生。

在此阶段，古人们主要采用试错法来进行药物防病治病的探索。

中国药理学会

中国药理学会中国药理学会是中国药理学家学术交流的第一个群众性组织，由中国生理学会和中国药学会药理专业委员会共同组建。

1985年被民政部正式批准为国家一级学会。

中国药理学会是由全国药理工作者自愿组成，依法登记注册的学术性、公益性、非营利性法人社会团体。

它由会员、通讯会员和资深会员组成。

目前官方注册会员近12000人，他们来自药理学相关高校、科研机构、医疗机构、企事业单位、政府机关、医药企业。

中国药理学会聚集了全国各地药理学相关教学、科研、应用、生产、科普等领域的优秀药理学家。

目前，中国药理学会下设心血管药理学、神经精神药理学、中药和天然药物药理学、生物化学和分子药理学、临床药理学、药物毒理学、抗炎免疫药理学、肿瘤药理学、化疗药理学、定量药理学、药物代谢、制药工业、教学和科普药理学、药物试验药理学、生殖药理学、海洋药物药理学、抗衰老和抗老年痴呆症药理学、治疗性药物试验、麻醉药理学、滋补药等28个专业委员会。

各专业委员会积极开展各自领域的学术交流，促进了我国各方面药理学的发展。

中国药理学会的主要任务是团结全国药理工作者，广泛开展学术活动，组织国内外药理工作者的学术交流与合作，全面提高我国药理研究、教学和应用水平，促进我国药理科学的发展、新药的研究开发和药物的科学应用。

目前，中国药理学会已与美国、日本、法国、俄罗斯、英国等国家的药理学会建立了稳定的双边学术交流与合作，并于2006年7月在北京成功举办了第15届世界药理大会。

来自全球60多个国家的3000多名代表出席了大会，受到了所有与会药理学家的一致好评，被国际药理学家联合会官员誉为世界药理学发展史上的里程碑。

中国药理学会主办有《中国药理学报》（英文版）、《中国药理学通报》、《中国药理学与毒理学杂志》、《中药药理与临床》、《中国临床药理学与治疗学杂志》、《医药导报》和《神经药理学报》等学术期刊，在国内外学术交流中发挥了积极的作用。

中国药理学会的内部刊物《中国药理通讯》也为会员信息交流提供了平台。

中国药学会2011年奖项和专项研究资助申报通知

中国药学会2011年奖项和专项研究资助申报通知
佚名
【期刊名称】《药学进展》
【年(卷),期】2011(35)3
【摘要】中国药学会科学技术奖该奖是2005年7月经国家科学技术部批准设立
的我国药学领域的科学技术奖，每年评选一次。

2011年项目奖励最高限额分为：一等奖2名、二等奖5名、三等奖8名，项目奖励金额（含税）分别为50000元、30000元、10000元人民币。

中国药学会将从获得奖励项目中，推荐国家科技奖
励项目。

【总页数】1页(PF0003-F0003)
【关键词】中国药学会;科学技术奖;奖励项目;申报;资助;专项;科学技术部;药学领域【正文语种】中文
【中图分类】R-092
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3.中国教育学会学校文化研究分会“‘十二五’学校文化建设研究”专项独立课题申报通知 [J],
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因版权原因，仅展示原文概要，查看原文内容请购买。

中国药理学会关于召开第九次全国代表大会及有关换届选举工作的通知

维普资讯
中国药理通讯２ｏｏ７年第二十四卷第一期
代表。关于会员资格，有效会员为２００６年以前已经缴纳会费的正式会员和２００７年６月以前缴纳会费并注册的新会员。理事候选人由各地区选举产生，新人会的会员不能担任理事候选人。２．会议讨论了理事候选人产生办法。会议决定每５０名会员产生一名理事候选人，并考虑地区分布情况。３．会议认为在换届选举过程中要发扬民主，充分协商，并成立换届工作小组。工作小组由林志彬教授、张均田教授、曾繁典教授、包定元教授、刘昌孝教授、李培忠教授、库宝善教授７人组成。领导小组要在发扬民主充分协商的基础上提出理事长和秘书长候选人，报常务理事会通过后，提交理事会和会员代表大会投票选举通过。４议对下一届学会领导人选进行了讨论，并对学会领导候选人进行了提名投票，每位参．会会代表推荐３名候选人，投票结果作为换届工作小组参考依据。５议决定，会员缴纳会费２０．会０７至２１００年四年会费一次缴纳１０元人民币。６００岁以上在册会员一次缴纳会费２０元人民币，作为终身会员，不再缴纳会费。０６．全国会员代表大会于２００７年１０月底或１初将在武汉召开，由武汉药理学会理事长华１月中科技大学武汉医学院陈建国教授负责会议筹备工作。７议还广泛讨论了学会的工作，提出了大量建设性的建议。．会中国药理学会

中国科学技术协会关于聘任第一批首席科学传播专家的通知

中国科学技术协会关于聘任第一批首席科学传播专家的通知文章属性•【制定机关】中国科学技术协会•【公布日期】2013.12.24•【文号】科协发普字[2013]75号•【施行日期】2013.12.24•【效力等级】团体规定•【时效性】现行有效•【主题分类】基础研究与科研基地正文中国科学技术协会关于聘任第一批首席科学传播专家的通知（科协发普字〔2013〕75号）各全国学会、协会、研究会，各省、自治区、直辖市科协，新疆生产建设兵团科协：为全面贯彻落实党的十八大和全国科技创新大会精神，根据《全民科学素质行动计划纲要实施方案（2011-2015年）》和《中国科协科普人才发展规划纲要（2010-2020年）》的部署，为加强科普人才队伍建设，提升科普公共服务能力，促进公民科学素质建设目标的实现，2013年，中国科协启动组建科学传播专家团队。

按照《中国科协办公厅关于组建科学传播专家团队的通知》（科协办发普字〔2013〕40号），各全国学会认真组织推荐，经研究审查，决定聘任朱邦芬等156名专家为第一批全国首席科学传播专家，聘期3年。

首席科学传播专家开展公益性科普活动时，可以“**学科首席科学传播专家”名义进行宣传和介绍。

各全国学会、各级科协组织要为科学传播专家搭好台、服好务，紧紧依托首席科学传播专家及科学传播专家团队，大力推进科学传播工作，不断提升学科科普服务水平和社会影响力。

希望首席科学传播专家及团队珍惜荣誉、承担责任，带领科学传播专家团队，按照《全民科学素质行动计划纲要实施方案（2011-2015年）》的总体部署，围绕党和国家经济社会发展中心任务和人民群众生产生活实际需求，大力开展科普创作、科学传播，推动拓展学科科普工作，团结引领广大科技工作者，积极投身公民科学素质建设，为实施创新驱动发展战略、全面建成小康社会、实现两个百年奋斗目标、实现中华民族伟大复兴的中国梦做出新的更大贡献！附件：第一批全国首席科学传播专家名单中国科协2013年12月24日附件第一批全国首席科学传播专家名单（共156人分学会按姓氏笔画为序）中国系统工程学会：中国腐蚀与防护学会：中国造纸学会：中国毒理学会：。

中国药理？

ORIGINALSeparation of Natural Food Pigments in Saponiﬁed and Un-Saponiﬁed Paprika Oleoresin by Ultra HighPerformance Supercritical Fluid Chromatography (UHPSFC)Terry A.Berger •Blair K.BergerReceived:21March 2013/Accepted:4April 2013ÓSpringer-Verlag Berlin Heidelberg 2013Abstract The natural pigments in paprika were rapidly and efﬁciently separated by ultra high performance super-critical ﬂuid chromatography.The separation of both un-saponiﬁed and saponiﬁed mixtures of paprika oleoresin were optimized,with run times of 10.6min.Three differ-ent C18columns,a cyano,silica and diol column,all 39100mm,with 1.8l m particles were compared.The best separation for the un-saponiﬁed sample was found with an SB-C18column,while the saponiﬁed samples were best separated on a bare silica,RX-Sil column.A SB-CN column allowed near optimum separation of both the un-saponiﬁed,and saponiﬁed samples,with similar run times.The best mobile phase was carbon dioxide (CO 2)modiﬁed with isopropyl alcohol (IPA),with a composition gradient.Fingerprints of several commercial pepper products indi-cated that one appeared to be colored with artiﬁcial dyes,while the color of a chili powder may have been enhanced with a paprika extract.Spectra,using CO 2with IPA as modiﬁer,produced a single maximum at 453nm,which appears to represent up to a 30nm solvatochromic shift from the maxima in most organic solvents.Acetonitrile (ACN)as modiﬁer produced spectra with two maxima and a similar solvatochromic shift.These results appear to be the ﬁrst on saponiﬁed paprika oleoresin samples using SFC.It is also the ﬁrst detailed report on the separation of un-saponiﬁed samples.The results are up to six times faster than comparable results by HPLC.It appears that SFC is a viable,superior alternative to HPLC for the analysis of this important commercial product,without using ACN,or chlorinated solvents.Keywords Ultra high performance supercritical ﬂuid chromatography (UHPSFC)ÁSub-2l m particles ÁSolvatochromic shift ÁPaprika oleoresin ÁCapsanthin ÁNatural food dyesIntroductionThere is a genuine public concern over the use of artiﬁcial dyes in foods and beverages,which has led to the wide-spread switch to pigments from natural products and foods.Peppers contain carotenoids which are some of the most intensely colored pigments in nature.Paprika (Capsicum annuum L.)has been used for centuries to color foods,and for decades for the commercial extraction of large amounts of red pigments to be used in processed foods.Up until a decade ago,virtually all such extractions were performed using relatively non-polar organic solvents,such as hexane,acetone,or dichloromethane.The use of such solvents created an additional problem in the form of solvent resi-dues in the extract,which are strictly controlled.Many of the techniques used to remove the solvents damaged the color and degraded the product.Fortunately,starting a little over a decade ago,there was a major shift away from toxic and expensive organic solvents,toward the use of super-critical ﬂuid extraction (SFE)using carbon dioxide (CO 2)as the extracting ﬂuid [1–3].At the end of the extraction,the CO 2simply evaporates,leaving no toxic residues.After the extraction solvents are removed,a viscous,intensely red liquid or paste is left behind called paprika oleoresin.The majority of the color is due to two com-pounds:capsanthin and capsorubin,although a number of other colored components are present.The quality and value of paprika and paprika oleoresin depends on the intensity of the color,but also on other qualities.InT.A.Berger (&)ÁB.K.BergerSFC Solutions,Inc.,9435Downing St.,Englewood,FL 34224,USA e-mail:tabergersfc@ChromatographiaDOI 10.1007/s10337-013-2466-yaddition to the most desired colored pigments,signiﬁcant amounts of b -carotene,and c -tocopherol,both anti-oxi-dants,are present,which tend to protect the pigments within the plant material,and are usually extracted with the pigments.Further,provitamin A is present in very high concentrations,compared to other natural sources.The presence of these compounds tends to increase the value of the product.Extraction changes the interactions between the desired compounds,and the other compounds that tend to protect them from degradation within the fruit.Proper storage becomes an issue.Both capsanthin and capsorubin contain two hydroxyl groups,one on each of the rings at the two ends of a long terpenoid central chain,as shown in Fig.1.As the fruits ripen,these hydroxyl groups form mono and di-esters with fatty acids,although some remain free.Capsanthin is present in the fruit both in its free form,and as mono-,and di-esters.Capsorubin is mainly present in ripe fruit as diesters [4,5].In one study [4],only 5.7%of all the capsanthin present was free,with 4mono-esters totaling 33.8%,and 5dies-ters totaling 60.5%.Free capsorubin represented only 6.7%of the total,while 10.2%was present as a mono-ester,and 83.1%was present as a di-ester.Capsanthin and its esters made up 78.0%of all the areas found at high wavelengths.Capsorubin,and its esters,only 2.8%.In the other study [5],44carotenoids were found.Only 6.8%of capsanthin was free with 4mono-esters and 5di-esters.After saponiﬁcation,60±3%of the total area was capsanthin and 7.7%was capsorubin.Due to their non-polar nature,the esters are concentrated in fatty globules which appear to stabilize the pigments.Formation of these esters has no impact on the color of the pigments,but results in multiple chromatographic peaks for each compound.High performance liquid chromatography (HPLC)has been the technique of choice [2,3,5–11]for determining the quality of paprika oleoresins.Many approaches use acetonitrile and/or dichloromethane as part of the mobile phase.It seems ironic,and a bit archaic,that extraction with organic solvents has been replaced with a much less toxic,greener alternative SFE,only to use those same toxic,polluting solvents to analyze the extracts by HPLC.With the raw extracts,chromatograms can be quite complex,sometimes with [70partially resolved maxima,with run times exceeding 75min.In order to simplify the chromatogram,and clarify the distribution of the key components,the oleoresins are sometimes saponiﬁed [11,12]to convert all the esters of the same compound,into the single free form.Saponiﬁcation was shown to dramatically decrease sample complexity,and could produce HPLC run times below 20min.However,there are many warnings about sample degradation accompanying saponiﬁcation.Supercritical ﬂuid chromatography (SFC)is generally considered to be a replacement technology for HPLC,since it is considered to be three to ﬁve times faster,less expen-sive to operate,and is greener.There appear to be only two rather obscure references to the separation of paprika oleoresin by SFC;an application note by Hewlett Packard in 1983[13]and a single chromatogram in a paper dealing with coupled SFE/SFC [14],using similar conditions,with similar results.In neither case were the samples saponiﬁed.A number of broad,distorted peaks were poorly resolved in 16–26min,although a relatively smaller number (6–10)of major components appeared to be present.The purpose of the present work is to determine if SFC could replace non-aqueous reversed phase HPLC for the analysis of either un-saponiﬁed or saponiﬁed paprika ole-oresins,and eliminate the use of chlorinated solvents,or acetonitrile.This would require a substantial improvement in peak shapes,and resolution compared to the sparse previous work.Further,it was of interest to use columns with sub-2l m particles,to try to rapidly resolve such a complex natural productmatrix.Fig.1Structures of the two most common components in paprika oleoresin.Thesecompounds are most commonly present as mono-and di-esters with fatty acids substituted onto the –OH groups on the end ringsT.A.Berger,B.K.BergerExperimentalInstrumentationAn Agilent Technologies Model1260Hybrid HPLC/SFC system(Waldbronn,Germany)was used as the chromato-graph,but used exclusively here in the SFC mode.The system includes an SFC conversion module that expands the use of the HPLC into an ultra high performance SFC (UHPSFC).The system has an upper pressure capability of 600bar.The instrumentation was previously shown to have extremely low extra-column dispersion[15],and can truly be classiﬁed as an UHPSFC.System control was through‘‘modern’’ChemStation.The SFC conversion module contains a powerful con-denser that allows the use of the vapor phase of CO2.Low cost industrial or beverage grade CO2can be used since non-volatile contaminants remain in the pared to organic solvents,this CO2is extremely inexpensive.The Model1315C diode array detector(DAD)was capable of collecting80Hz data,and was used with a 3mm,2l L low dispersionﬂow cell.All the chromato-grams were collected with spectra.The slit was set to1nm. The bandwidth of each of the signals was set to2nm. Detection was at220,425,440,and470nm,without a reference.The mobile phase was preheated in the right hand heat exchanger of the thermal control compartment(TCC) before entering the column.The left hand heat exchanger (LHX)was used to control the temperature of the mobile phase to the temperature of theﬂow cell to avoid issues with changes in refractive index.A hand held meter with a thermocouple was used to monitor the cell temperature, and the LHX temperature was changed manually,although the DAD was set to control its internal temperature,and the actual cell temperature changed only very slightly.MaterialsThree different C18columns:SB-C18,Eclipse Plus-C18,and Eclipse XDB-C18,plus an SB-CN column,and an RX-Sil column,all39100,1.8l,all from Agilent Technologies, were evaluated.In addition,an Epic Diol HILIC column from ES Industries,West Berlin,New Jersey,with the same 39100mm,1.8l m format was evaluated.Acetonitrile(ACN),acetone,heptane,isopropyl alcohol (IPA),ethyl acetate(EtAc),methanol,and water,all Om-nisolve HPLC grade,were purchased from SECO,Aston, PA.Potassium hydroxide(KOH)pellets were obtained from EMD,Gibbstown,NJ,USA.Methanolic KOH(5%) was prepared by dissolving5g KOH in100mL methanol. Carbon dioxide was beverage grade,obtained from Terry Supply Co.,Sarasota,FL,USA.A sample labeled‘‘Capsanthin(paprika extract,vege-table oil solution)’’was purchased from TCI Americas, Portland OR,USA.A store brand,and a name brand paprika,a chili powder,and an Italian ground pepper product were purchased at local markets.The store brand paprika,the chili powder,and the Italian pepper,all listed silicon dioxide as an ingredient on their labels,one said to ‘‘aidﬂow’’.Preparing Paprika OleoresinsAn SFE instrument was not available.Consequently, extraction with an organic solvent was resorted to.The paprika samples,chili power sample,and the red Italian pepper product,were each extracted,with heptane:acetone. In addition,one of the paprika’s was also extracted with acetone,only.Two grams of each sample were placed in a20mL scintillation vial and10mL of acetone:heptane(50:50v/v) was added.The samples were sonicated for6min,then let stand for10min to settle particulates.The liquid was decanted off and an additional5mL of acetone:heptane was added,sonicated,and decanted with the same times. Most of the red coloration was removed but there was no attempt to be quantitative,or extract exhaustively,since this is a feasibility study about the chromatographic sepa-ration of the compounds present.The extracts from each sample were combined,and centrifuged at3,400rpm for10min to settle particulates. Care was taken to minimize exposure to light.Pooled extracts were dried down on large watch glasses,at room temperature with high airﬂow,until no noticeable change in volume occurred.All the samples produced very vis-cous,deep red liquids.These liquids were dissolved in ethyl acetate,transferred to amber2mL autosampler vials and analyzed as is.Some of the samples were also sub-jected to several methods of saponiﬁcation.Sample SaponiﬁcationThe raw extracts contain the free forms,plus mono-,and di-esters of the colored components.In order to simplify the chromatograms,the esters were saponiﬁed to convert them to the free form.There are a number of different saponiﬁ-cation procedures in the literature,using5–60%metha-nolic KOH.However,there are also many warnings about the instability of many of the compounds when excessive heat is used.Thus,there is a dichotomy between adequate saponiﬁcation,and destruction of part of the sample.Theﬁrst method evaluated[2],consisting of overnight saponiﬁcation with5%methanolic KOH,at room tem-perature,was dramatically unsuccessful.Separation of Natural Food Pigments in Paprika OleoresinIn an intermediate approach,a1g capsanthin sample in vegetable oil,was diluted with3mL heptane,then3mL 5%KOH in methanol,was added.The mixture was heated in a water bath at65°C with stirring for20min[11,12]. The samples were in a20mL scintillation vial,with a tightly closed screw cap.After cooling,3mL water was added to remove KOH.Three millilitre of ethyl acetate were added along with enough salt(NaCl)to insure the lower phase was saturated.This produce an intensely col-ored upper organic phase of mostly heptane/ethyl acetate, and a pale yellow but clear lower,mostly aqueous/metha-nol,phase.Unfortunately small amounts of many unsapo-niﬁed components remained in subsequent chromatograms.Theﬁnal approach tried,involved the same initial steps but increased the heating to reﬂux the solvent at80–85°, inside the sealed vial,for a minimum of30min.After cooling,and the addition of water,salt,and ethyl acetate, the sample slowly separated into two phases.Small vari-ations in the volumes of the various solvents produced poorer results,sometimes with three phases with color distributed between two of the three phases.The upper, intensely colored phase was removed,and rewashed with an additional3ml of water,plus salt,then,part was transferred to a2mL amber autosampler vial for analysis. Such samples yielded the simplest chromatograms,but there were still a number of trace components,which might represent unsaponiﬁed esters.The salt had a major impact on the nature of the phases. Without the salt,an emulsion often formed on stirring,and the lower,mostly aqueous phase often had a much deeper orange color.The addition of salt broke the emulsion, created two distinct phases,and caused additional orange colored components to partition into the mixed organic phase.The acetone extract of paprika produced a three phase system when the water was added.Upper and lower phases contained little color,but spherical globules of intense red color were lying on the meniscus between the two main phases.With the addition of ethyl acetate and salt,the third phase disappeared and the red color partitioned into the upper organic phase.Results and DiscussionChromatographic ApproachIn an early1980s application note,Gere[13]used1% ethanol premixed into CO2,and a4.69150mm,column packed with3l m Hypersil ODS to partially separate a paprika oleoresin.It was then felt that the long terpenoid chains of the various pigments would likely interact well with a long hydrocarbon chain of a non-polar phase,such as C18.The use of3l m particles was relatively new at the time.Gere also used very low concentrations of modiﬁer.He dispensed speciﬁc volumes of modiﬁer into a small(sev-eral liter)high pressure cylinder,which was then sealed, and CO2was added up to a desired weight.Theﬂuid was subsequently pumped as a singleﬂuid,precluding the use of composition gradients.It is now known that such an approach results in a continual change in modiﬁer con-centration,since,in the cylinder,the vapor phase and liquid phase have different compositions[16].A further compli-cation arises,since it is not recommended to pump at compositions signiﬁcantly below5%modiﬁer,since doing so tends to createﬂow and composition noise,due to the very low frequency of the modiﬁer pump.Column and instrument technology have changed dra-matically since the1980s.There is now a much greater emphasis on the use of even smaller sub-2l m particles, and a number of variations of silica supports are now available.For example,Agilent manufactures three dif-ferent kinds of C18stationary phases,on different silicas, each in1.8l m totally porous particles.To achieve a weaker mobile phase,it is now preferable to use a somewhat higher concentration of a weaker sol-vent,or even use a mixed modiﬁer,such as10%IPA dissolved in heptane.For this work,it was decided to ini-tially use the less polar isopropyl alcohol as modiﬁer, instead of the ethanol used by Gere.On Snyders P’solvent strength scale[17,18],ethanol is4.3while IPA is3.9(on a scale of0to&10).Several other modiﬁers were also evaluated.Un-Saponiﬁed Capsanthin in Vegetable OilAn un-saponiﬁed commercial sample,labeled‘‘capsanthin, paprika extract in vegetable oil’’,was used through-out method development.After a number of false starts,a gradient elution method was developed that could be used on all the columns tried.The results on an SB-C18,Eclipse Plus-C18,and an Eclipse XDB-C18column are presented in Fig.2.It was found that the use of very low modiﬁer concentrations was not necessary,since the vast majority of sample components were signiﬁcantly retained at5%IPA. In fact,a composition gradient to higher concentrations was desirable to shorten run times.The IPA concentration was held constant at5%for 0.6min,then increased to20%at6.6min,then held at 20%until10.6min.Flow rate was1.95mL min-1.The column pre-heater temperature and column outlet pressure were50°C and150bar respectively.The DAD was con-ﬁgured to continuously collect spectra with a slit width of 1nm,and aﬁlter setting of[0.03min.Most of theT.A.Berger,B.K.Bergerchromatograms shown were collected at440nm with a 2nm bandwidth.The three1.8l m C18columns all produced similar,but not identical chromatograms,with many incompletely resolved maxima,with three larger peaks near the end of the chromatograms.All showed substantial improvements in resolution and peak shapes compared to earlier reports [13,14].Thirty or more maxima were observed.Retention decreased in the order:SB-C18,Eclipse Plus-C18,and Eclipse XDB-C18.All three columns produced signiﬁ-cantly higher resolution in shorter times compared to the 3l m ODS column used by Gere.The chromatograms were fast,despite the complexity of the sample,due largely to the use of sub2l m particles. The column hold-up time was less than0.3min.Pressure drops were modest at200bar or less.All the components appear to have eluted from each of the three columns in less than8min.However,the patterns of small peaks between2–3and3–5min(Fig.2),differed signiﬁcantly between the columns,and the signals seldom returned to the baseline,between major maxima.The pattern of the three larger peaks,near the end of the chromatograms closely resembled a pattern in chromato-grams in a reversed phase HPLC report[9],also collected on C18columns,but using mixtures of acetone,methanol and water as mobile phases,which required[70min run time.A shallower gradient,over a longer period,was used to attempt to near baseline resolve as many of the components as possible.This gradient consisted of an initial hold at5% for2min,followed by a gradient to12.5%IPA,at 22min,then hold to25min.The other conditions were the same: 1.95mL min-1,50°C,and150bar.Resolution improved somewhat,and at least ten more maxima could be discerned in the resulting chromatograms,as shown in Fig.3.The signals returned to near the baseline between the major peaks.Unfortunately,capsanthin,and capsorubin and their fatty acid mono-and di-esters have nearly iden-tical spectra[4].Without a mass spectrometer or NMR analysis or saponiﬁcation they cannot be differentiated.Alternate ModiﬁersIt was of interest to determine if a change of modiﬁer might change,or improve,resolution and selectivity.The SB-C18Separation of Natural Food Pigments in Paprika Oleoresinwas used as representative of C18columns and the IPA was replaced with ACN,EtAc,and acetone.The results, shown in Fig.4,indicate only subtle differences in selec-tivity,compared to IPA.Each is classiﬁed as a type VI solvent,whereas IPA is a type II solvent[17,18].More Polar ColumnsMore polar stationary phases were also evaluated to see if selectivity could be changed.The results from an SB-CN,a RX-Sil,and an Epic Diol HILIC column,each 39100mm,packed with1.8l m particles,were com-pared to the SB-C18column result,as shown in Fig.5.The same5–20%gradient,over10.6min,was used with IPA as modiﬁer.Dramatic changes in selectivity were evident.The low polarity solutes,present in the un-saponiﬁed sam-ple,showed signiﬁcantly less retention on all the more polar columns,compared to the SB-C18column.Both the RX-Sil and Epic Diol HILIC exhibited very little retention for the vast majority of the area under the peaks,although both indicated the presence of a large number of minor components.The SB-CN column,on the other hand,produced an intermediate chromatogram with the same time frame as the Eclipse XDB-C18column,but with a very different selectivity from any of the C18columns.The SB-CN column was further evaluated for the separation of the un-saponiﬁed sample by using several alternate modiﬁers: ACN,MeOH and EtAc.This time ACN and EtAc showed signiﬁcantly different selectivity compared to the alcohols, as shown in Fig.6.Both resolved what appear to be clus-ters of related groups of small peaks that eluted both before and after the main components.It would be very interesting to speciate these peaks with an appropriate mass spec-trometer.A substantially higher concentration of ethyl acetate was required(30%)to remove the late eluters. Methanol was the strongest modiﬁer and generated the least retention using the standard gradient.The SFC results,using unsaponiﬁed paprika oleoresin exhibit higher resolution in much shorter times compared to HPLC,while potentially avoiding the use of chlorinated solvents,or acetonitrile.Such results,combined with an appropriate mass spectrometer should allow speciation, without saponiﬁcation.T.A.Berger,B.K.BergerSaponiﬁed Capsanthin in Vegetable OilSaponiﬁcation is intended to simplify the chromatograms and make it easier to determine the commercial value ofthe product,at least by quantifying the capsanthin and capsorubin present.However,cleaving the esters,can result in sample degradation,and creates somewhat more polar compounds than the esters.This change in polarity of the solutes had signiﬁcant implications for the choice of stationary phase.Unlike the results with the unsaponiﬁed sample,none of the C18columns yielded acceptable chromatograms of the saponiﬁed sample,by exhibiting minimal retention,and minimal separation of the components.The SB-C18col-umn was more retentive of the saponiﬁed components, compared to the other two C18columns.The more polar SB-CN,RX-Sil,and Epic Diol HILIC columns retained the saponiﬁed sample much more strongly,with better peak shapes and resolution.This behavior is opposite to the results with the un-saponiﬁed sample.The results with the SB-C18column using the sapon-iﬁed sample were compared to SB-CN,RX-Sil,and the Epic Diol HILIC column,as shown in Fig.7.The chro-matograms of the saponiﬁed sample are much simpler, with one main peak,as desired.The main peak was nearly baseline resolved on both the RX-Sil and Diol columns,using the standard fast gradient.On all the more polar columns,the main peak tended to front signiﬁcantly. This is the only peak in the chromatogram that signiﬁ-cantly fronts.Spectra from the leading and trailing edges were virtually identical,but the peak purity feature of the DAD and ChemStation suggests this peak was impure. Resolution of this peak was never improved under any conditions tried.Spectra were not very helpful for purity determinations,since many of the peaks exhibited virtu-ally identical spectra.There are vague hints in the liter-ature that the impurity in the peak may be capsanthin epoxide.For clarity,the chromatograms of the saponiﬁed and unsaponiﬁed samples using RX Sil are compared in Fig.8. Virtually none of the larger peaks in the chromatogram of the saponiﬁed sample are evident in the unsaponiﬁed chromatogram.This suggests the main components had been almost completely esteriﬁed in the un-saponiﬁed sample,and that the saponiﬁcation was a success.However, the largest peak in the saponiﬁed sample in Fig.8only represents roughly46%of the total area at470nm,and is apparently impure.This is inconsistent with the HPLC lit-erature,which suggests capsanthin and its esters should be present at60to78%[4,5].Separation of Natural Food Pigments in Paprika OleoresinTemperature EffectsIt has sometimes been suggested that modest changes in temperature might result in changes in selectivity.Changing temperature with a shallower gradient was used to try to maximize resolution of the saponiﬁed sample.A gradient method of5%IPA for2min,then15%at22min,with a hold to25min,1.95mL min-1,150bar was used,and the temperature was varied from40to60°C.While there wereminor changes in the separations,the over-all result was not much different,as shown in Fig.9.These chromatograms were collected with an inadequately saponiﬁed sample.Most of the small peaks before12–14min are un-saponiﬁed components and can be ignored.The region of interest is both just in front,and behind the major peak.Resolution is improved due to the shallower gradient and longer retention, but temperature had only a minor effect on selectivity.The main peak continued to front.Other ModiﬁersMethanol and acetonitrile were compared to IPA as modi-ﬁers,using the RX-Sil column and the standard fast gradi-ent.The results shown in Fig.10,indicate IPA gave the best results among the modiﬁers tried.Methanol was too strong. ACN was surprisingly weak,yielding a severely fronting main peak,and did not elute everything,even when the concentration was held at20%for16min.This is in contrast to the result with the unsaponiﬁed(less polar?) sample,where ACN produced less retention than IPA.Real SamplesThe SB-C18column,with the fast IPA gradient,were used to make rapidﬁngerprints of a number of other unsaponi-ﬁed samples.Two commercial paprikas,a chili powder, and an Italian pepper product,purchased at a local market, were extracted using acetone\heptane,as described earlier, and dried down to viscous,deep red oleoresins,which were then taken up in ethyl acetate.The oleoresins accounted for approximately10%of the original samples,by weight.All but one of the chromatograms was nearly identical to the commercial capsanthin sample,as shown in Fig.11. However,the Italian pepper product appeared to exhibit an extremely simple chromatogram,with one very large peak, with an absorbance of1,200mAU,and a smaller secondary peak of&200mAU,as seen in the bottom chromatogram of Fig.11.On a much-expanded scale,a very faint,complex chromatogram emerged,with the largest peak less than 10mAU high,as shown in the top of Fig.12.This faint chromatogram is compared to a capsanthin chromatogram (bottom,Fig.12),and indicates that the compounds presentT.A.Berger,B.K.Bergerin the two samples are substantially different,as one might expect,since the peppers are different species.The major peaks are signiﬁcantly shifted in time,and there are many minor peaks past7min,which are not present in the paprikaextracts.The visual color of this sample was also different from all the other samples in that there was no hint of the orange component present in the paprika oleoresins.It was speculated that the color of this sample had been signiﬁcantly enhanced using one or two artiﬁcial dyes.The chili pepper result presents another interesting sit-uation in that one would not expect the proﬁle of a spicy chili pepper to be the same as a paprika,since the two peppers involved are also different species.However,the chromatographic proﬁle of this chili powder extract is vir-tually identical to the paprikas.This suggests that the color of this chili powder may have been enhanced with a paprika extract,although the label makes no mention of this.SpectraFew pure standards are available,due largely to their unstable nature.Clearly,the commercial‘‘capsanthin’’is a mixture of dozens of components.Consequently,capsan-thin and capsorubin are often identiﬁed by their UV–Vis spectra.Unfortunately,many of the carotenoids tend to undergo solvatochromic shifts,depending on the polarity of the solvent they are dissolved in.The shift in maxima with changes in solvent can apparently be dramatic.In an extreme example[19]it was reported that the maxima for lycopene shifted from444,470,502in petroleum ether,to 477,508,and548in carbon disulﬁde.There are apparently no references to the spectra of these compounds in CO2basedﬂuids.Several sources list the absorbance maxima of capsanthin and capsorubin in hexane,benzene,petroleum ether,and ethanol,as shown in Table1.References list from1to3maxima for both capsanthin and capsorubin.The absorbance maxima reported differ between references by as much as13nm, depending on the solvent.Spectra were collected from individual peaks in the chromatograms,using a slit width of1nm,and a band-width of2nm ing IPA as modiﬁer the spectra recorded from the leading and trailing edge of the main peak in Fig.10,are presented in the top of Fig.13.The spectra appear to be virtually identical, although the peak purity algorithm built into theSeparation of Natural Food Pigments in Paprika Oleoresin。

中国药理学会第十次全国会员代表大会开幕词

更为有利的条件。我们肩负着光荣的历史使命，伟大的艰巨任务，我们要团结一致，为了不负
伟大的时代，积极努力，创造更加辉煌的业绩，为实现中华民族的伟大复兴贡献自己的力量。
中国药理学会也将继续在科协的领导下，坚持科学发展观，加强学会建设，为全体会员提供更好的学术交流的平台，为社会服务的平台，真正成为全体会员之家。
科作为连接医学药学、基础临床和多门相关学科的桥梁学科和交叉学科，在前所未有的良好发
展环境中，进入了快速发展的新时期。全国药理学工作者围绕新药创制、合理用药、科学发展、保障民生、服务社会等重大科学问题，辛勤劳动，积极创新，艰苦攻关，勇攀高峰，取得了举世瞩目的成就。我学会在理事会团结一心，和全体会员的共同努力，促进了的学会的发展，提
高了我学会在国内外的影响和声望，在国际科学领域的影响不断扩大，受到国际同行的关注和
尊重。
各位代表，我们正处在药理学科发展的最佳机遇期，社会发展使人民更加关注健康水平和医疗水平，对药物的合理应用和新药的创制提出更高的要求，科学进步为药理学的发展提供了
堂，交流学术，共商我国药理学发展大计，我仅代表中国药理学会第九届理事会向给位代表、各位来宾致以亲切的问候和崇高的敬意！从２１年下半年，我们学会开始了换届的准备工作，经过各地换届工作组各位同仁根据我０１们学会的章程，经过辛勤努力，在全体会员的支持下，顺利完成了会员登记注册、会员代表选举和新一届理事候选人的推荐工作。通过全体会员的共同努力，各项工作有条不紊，紧张有序，符合学会章程和科协的有关规定，充分展示了全体会员对学会工作的支持和对我国药理学发展的关心。在此，我代表第九届理事会向出席会议的各位代表，并通过各位代表向全国学会会员

中国药理学会理事长秘书长应邀访问英国药理学会

应邀参加了这次欧洲药理学盛会，受到了欧洲药理学会和英国药理学会的热烈欢迎
和热情接待。杜冠华理事长和张永祥秘书长在访问期间，与参加欧洲药理学会的欧洲药理学家进行了广泛的接触，对药理学发展和药理学学术交流等问题进行交流，同时介绍
中国药理通讯２００８年第二十五卷第四期
过程，摆脱当前普遍出现的药物发现瓶颈问题是，如何充分利用我国现有技术条件，
提出新颖和创造性的药物发现模型和策略，提高创新药物成功率是我国药物研究相关科研人员、管理人员、政府官员等急需考虑的问题。本次沙龙正是在此背景下，以 “ 药物发现一新模式和新策略 ”为主题，紧紧围绕药物发现过程中应用的新技术和新方法；药物发现新的理念；国内外针对药物研发
的政策管理体制等内容进行研讨。与会专家包括旁听人员都积极踊跃发表自己的认识和观点，特别是在药物发现过程中药物靶点的定义和功能研究新技术新方法、药
物虚拟筛选的新思路、药物发现的多靶点研究新理念、药物发现早期安全评价、中药新药研究新的突破口等方面有多次新火花的碰撞及新思想的产生。本期沙龙会场气氛非常活跃，多次出现争抢发言，提观点、讲创新、质疑、争辩不断，所有与会专家认为这样个性化、辩论式的交流方式是国内现有学术交流活动中少有的，对大家启发很大，收益甚多。
药学发展前沿论坛大会主席台
１２
本期沙龙由中国科协学会学术部主办，中国药理学会承办。《科技日报》科学、《

中国药理学会九届四次常务理事扩大会议暨新春联谊会圆满召开

中国药理通讯２ｏ第二十六卷第一期０９年
中国药理学会九届四次常务理事扩大会议暨新春联谊会圆满召开
中国药理学会办公室
中国药理通讯加０９年第二十六卷第一期
中国药理学会九届四次常务理事扩大会议暨新春联谊会于２００９年１月１１日在北京宣武门商务酒店举行。２００８年已经过去，在这不平凡的一年里，中国药理学会辑部２００８年工作统计
中国药理学会办公室
编辑部名称ｌ１一２月总册数中国临床药理学与治疗学杂志医药导报中国药理学通报中国药理学与毒理学杂志《国药理学报》中１００２０４００２０３２０７０１０Ｏ５ｏ１２０３０论文
在中国科协的领导下，在各位常务理事、理事和全体会员的共同努力下，中国药理
学会各方面工作都取得良好进展，学会建设有了显著的进步，学术交流水平进一步提高。２００８年已经过去，２００９年已经到来，新的一年我们面临着更艰巨的任务，
学会理事会将团结一致，做好各项工作。
总篇数３０篇０７０篇８４２篇１８０篇１８篇８
中药药理与临床中国药理学会通讯总计
１００２０１００６０１７０４４０
２２篇５１４篇７２８１６篇
２

2011年7月7日至10月25日缴纳会费的会员名单

吉林省集安益盛药业股份有限公司吉林省集安市文化东路１—２号７Ｏ
尹笠佥
北京市海淀区太平路２号东门７
李海静董方霆周涛
１０３０８５
黑龙江省
解放军总医院
北京市海淀区复兴路２号８
杨新波刘明闫娟娟周小江胡园
１４０５０２
山西省太原市坞城路９号２
刘晓节
北京市
河北省
１００５００
中国医学科学院基础医学研究所药理系
００００５０
北京市东单三条５号
孙兰一
中国南车集团石家庄车辆厂医院
河北省石家庄市
丁新侃
１０１０００
首都医科大学附属北京中医医院
０５００００
刘庆山庞宗然裴凌鹏覃筱燕王惠萍
鲁碧南
王慧晔于婉婷刘世杰郭旭辉
王朝晖段云霞方
马芹芹李雪丽郑玲玲张嫂
亮
陈小玉
王白槐岩
１０４００４
李静雅白永飞胡华刚
北京大学人民医院
刘晓芳肖璇
北京市西城区西直门南大街１号１
顾健张春燕
衣丽娜
１００００５
１０８００４
中国医学科学院药物研究所
北京市宣武区先农坛街１号吕扬朱海波贾少博李新娅杨柳范宝妍徐瑞明顾林娟李瑾
清华大学医学院北京市海淀区
张路王钊
连泽勤冀呈雪
张建军刘丽丽
康瑞霞黄倩

中国药理学会第九届第四次常务理事会中国药理学会2008年工作报告

本次常务理事会还特别邀请了各专业委员会主任委员和学会主办的学术期刊编辑部主任参加，目的是为了共同商讨学会工作计划，促进我学会２００９年的工作。
２００８年，中国药理学会的工作主要有以下方面：
一
、
加强学会改革，健全学会规章制度，促进学会发展
是经过激烈竞争、严格评审后，中国科协批准立项的试点性项目，通过该项目的支
持，我学会网站的内容不断丰富，网站功能显著增加，符合开展网上学术交流的要
求。
２
中国药理通讯２０第二十五卷第四期ｏ８年
影响力。２００８年，一批留学回国人员和药理学科研教学骨干加入药理学会，使我会注册
会员人数达到历史最高水平，实际缴纳会费会员４３人。１１
二、深刻领会科协工作精神，加强学会改革
长期以来，科协对我会的发展极为关注，为我会发展给予了极大的支持。我会
在申请中国科协项目时，我会会员张莉、理事张天泰和学会办公室人员为申请
这些项目付出了辛勤的努力。通过科协项目的实施，有效推动了我会的工作和学会
的改革，提高了学会的学术交流水平。
三、创新学术交流形式，提高学术交流效果
与地方政府合作，推动地方经济发展。
中国药理通讯２０年第二十五卷第四期０８
在一年的学会工作中，学会常务理事、理事和会员对学会的发系列建设性建议。收集到的建议如适时举行全国性学

第十三届中国科协年会生物医药博士论坛会议纪要

第十三届中国科协年会生物医药博士论坛会议纪要
佚名
【期刊名称】《中国药理通讯》
【年(卷),期】2011(028)004
【摘要】“第十三届中国科协年会生物医药博士论坛”于2011年9月22日在南开大学综合实验楼报告厅召开。

本次会议由中国药理学会主办，天津市药学会、天津市药理学会承办，南开大学、天津大学、天津药物研究院、天津中医药大学、天津医科大学协办。

【总页数】1页(P7-7)
【正文语种】中文
【中图分类】R95
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10：15-10:30
俸珊（天津中医药大学）白芷总香豆素对川芎嗪药代动力学影响及其机理研究
10：30-10：45
杨帆(医科院药物所)神经氨酸酶抑制活性测定标准研究
10：45-11：00
滕杰（天津医科大学）山尖菜化学成分的研究
11：00-11：15
陈健（四川大学基础与法医学院）毛蕊异黄酮经由雌激素受体及ERK1/2的激活促进雌激素受体阳性细胞增殖的体内外研究
和反应器培养中活性成分和营养成分的动态变化
14：45-15：00
白晓宇（医科院药物所）WS070133的镇静及协同催眠作用的研究
15：00-15：15
赵明明（中国医学科学院北京协和医学院药用植的验证
11：15-11：30
谷元（天津药物研究院）苯丙氨酸二肽衍生物在大鼠体内的代谢途径研究
11：30-11：45
田硕（医科院药物所）口服黄芩素对大鼠CYP450亚型活性的影响
11：45-12：00
宋浩静（山东大学齐鲁医院）银杏内酯B注射液在Beagle犬药代及毒代动力学研究
12：00-13：00午餐
学术报告（13：00-16：00）
执行主席娄建石教授（天津医科大学）胡人杰教授（天津医药科学研究所）
13：00-13：15
李春雨（天津市新药安全评价研究中心）基于代谢组学技术的大黄治疗CRF的作用机制研究
13：15-13：30
梁寒峭（中国医学科学院药用植物研究所）麦冬内生真菌的分离及抗菌活性的研究
13：30-13：45
张小锐（军事医学科学院毒物药物研究所）TLR4是介导枸杞多糖LBPF4-OL免疫调节功能的重要作用位点
15：15-15：30
王新廷（中国药科大学）I型糖尿病对大鼠脑和外周组织胆固醇含量的不同影响
15：30-15：45
赵文静（山东大学齐鲁医院临床药理研究所）大鼠喉运动神经元接受儿茶酚胺类神经递质的投射
15：45-16：00
孙加琳（医科院药物所）临床常用尼群地平片在大鼠体内药代动力学研究
16：00-16:15茶歇
2011年第十三届中国科协年会
生物医药博士论坛日程
会议时间:2011年9月22日
会议地点：南开大学药学院学术报告厅
9月22日
开幕式
执行主席：白钢教授（南开大学）
08：30-09：00
中国药理学会理事长杜冠华教授致开幕词
天津市药监局王生田局长致辞
天津市科协领导致辞
中国工程院院士、天津市药学会会长、天津药理学会会长刘昌孝院士致辞
09：10-09：30与会者合影留念
学术报告（9：30-12：00）
执行主席高文远教授（天津大学）何新教授（天津中医药大学）
09:30-09:45
张静泽（天津大学）中药胃肠安丸作用物质基础研究
09：45-10：00
田成旺（天津药物研究院）藏茵陈利胆退黄药效物质基础初步研究
10：00-10：15
祖勉（医科院药物所）茶黄素及其衍生物的体外抗流感病毒活性研究
17:00-17:15
郭晶（医科院药物所）蛋白酪氨酸激酶抑制剂高通量筛选的建立和应用
17:15-17:30
胡蕴慧（医科院血液学研究所）联合抑制sorcin和mdr1基因逆转K562/A02细胞株与MCF-7/A02细胞株多药耐药性的研究
17:30-17:45
刘韦鋆(天津中医药大学)建立一种用于同步评价肠溶制剂释放/吸收特征的仿生系统
13：45-14：00
李亚卓（天津药物研究院）苯醌还原酶II型与天然类黄酮化合物Apigenin复合物的蛋白晶体结构研究
14：00-14：15
郭鑫金（大连医科大学药学院）肠道PEPT1和肾脏OATs是JBP485与赖诺普利相互作用的靶点
14：15-14：30
辛文妤（医科院药物所）DL0309对LPS诱导小鼠RAW264.7细胞NO生成及iNOS表达的影响
学术报告（16：15-18：00）
执行主席王平保教授（天津药物研究院）白钢教授（南开大学）
16:15-16.30
黎晌（澳门大学）毛蕊异黄酮的促血管新生研究
16:30-16:45
周丹（医科院药物所）新型双重胆碱酯酶抑制剂的发现与药效学评价
16:45-17:00
张恒（医科院放射医学研究所）白藜芦醇对造血系统辐射损伤的防护作用
17；45-18：00
吴全忠(天津市天士力制药有限责任公司)CDAP活化多糖制备b型流感嗜血杆菌多糖PRP-蛋白结合物的研究
18：00-18：30
颁奖
致闭幕词(中国工程院院士、天津市药学会会长、天津药理学会会长刘昌孝院士)
18：30-20：00
晚餐