泰索帝版说明书

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泰索帝版说明书

核准日期：2006年11月修改日期：2008年1月2009年3月多西他赛注射液说明书请仔细阅读说明书并在医师指导下使用【药品名称】通用名称：多西他赛注射液商品名称：泰索帝® TAXOTERE®英文名称：DOCETAXEL INJECTION汉语拼音：DUO XI TA SAI ZHUSHEYE【成份】化学名称： (2R,3S)-N-羧基-3-苯基异丝氨酸,N-叔丁基酯,13-酯链上5β-20-环氧-1,2α, 4,7β,10β, 13α-六羟紫杉醇-11-烯-9-酮4-乙酸2-苯甲酸酯三水合物泰索帝®:20mg –每支:20mg注射液为将相当于20mg 多西他赛(无水)的多西他赛三羟化合物，溶解于吐温80中而制成。

泰索帝®:80mg –每支:80mg注射液为将相当于80mg 多西他赛(无水)的多西他赛三羟化合物，溶解于吐温80中而制成。

每毫升泰索帝®注射液含有40 mg无水多西他赛。

泰索帝®溶剂-浓度为13% w/w 的注射用乙醇（以95%计）水溶液。

化学结构式：•3H2O分子式：C43H53NO14•3H2O分子量：本注射剂的全部辅料为：浓溶液：吐温80和氮气；溶剂：95%乙醇和注射用水。

【性状】黄至棕黄色的粘稠液体，配有溶剂。

几乎不溶于水，高脂溶性。

【适应症】多西他赛的适应症如下：乳腺癌1. 适用于局部晚期或转移性乳腺癌的治疗。

2. 泰索帝（多西他赛）联合曲妥珠单抗，用于HER２基因过度表达的转移性乳腺癌患者的治疗，此类患者先期未接受过转移性癌症的化疗。

3. 泰索帝（多西他赛）联合阿霉素及环磷酰胺用于淋巴结阳性的乳腺癌患者的术后辅助化疗。

非小细胞肺癌适用于局部晚期或转移性非小细胞肺癌的治疗，即使是在以顺铂为主的化疗失败后。

【规格】（1）：20mg；（2）：80mg【用法用量】多西他赛只能用于静脉滴注。

推荐剂量:一般性多西他赛的推荐剂量为每三周75mg/m2滴注一小时。

安维汀-抗血管生成治疗

VEGF单抗安维汀®通过多种机制提高化疗疗效
现有肿瘤血管系统1–3
退化
新生血管生长1–3, 8
抑制
现存血管系统11–13
抗通透性
持续提高缓解率4–7 持续控制肿瘤生长8–10 减少胸水和渗出液2, 3, 11, 14–20
1. Hurwitz H, et al. N Engl J Med 2004; 350: 2335-2342. 2. Jain RK. Nat Med 2001; 7(9): 987-990. 3. Margolin K. Curr Oncol Rep 2002; 4: 20-28. 4. Hu L, et al. Am J Pathol 2002; 161(5): 1917-1924. 5. Kaya A, et al. Respir Med 2004; 98: 632-636. 6. Des Guetz G, et al. Br J Cancer 2006; 94: 1823-1832. 7. O'Byrne KJ, et al. Br J Cancer 2000; 82(8): 1427-1432. 8. Yuan A, et al. Int J Cancer (Pred Oncol) 2000; 89: 475-483. 9. Escudier B, et al. Lancet 2007; 370: 2103-2111. 10. Dickson PV, et al. Clin Cancer Res 2007; 13: 3942-3950. 11. Sandler A, et al. N Engl J Med 2006; 355: 2542-2550. 12. Miller K, et al. N Engl J Med 2007; 357: 2666-2676. 13. Gerber HP, Ferrara N. Cancer Res 2005; 65: 671-680. 14. Mabuchi S, et al. Clin Cancer Res 2008; 14: 7781-7789. 15. Wild R, et al. Int J Cancer 2004; 110: 343-351. 16. Mesiano S, et al. Am J Pathol 1998; 153(4): 1249-1256. 17. Willett CG, et al. Nat Med 2004; 10(2): 145-147. 18. O’Connor JPB, et al. Clin Cancer Res 2009; 15: 6674-6682. 19. Prager GW, et al. Mol Oncol 2010; 4: 150-160. 20. Ribeiro SCC, et al. Respirology 2009; 14: 1188-1193. 21. Watanabe M, et al. Hum Gene Ther 2009; 20: 598-610. 22. Bellati F, et al. Invest New Drugs 2010; 28: 887-894. 23. Huynh H, et al. J Hepatol 2008; 49: 52-60. 24. Ninomiya S, et al. J Surg Res 2009; 154: 196-202. 25. Bergers G, Benjamin LE. Nat Rev Cancer 2003; 3: 401-410. 26. Kim KJ, et al. Nature 1993; 362(6423): 841-844. 27. Folkman. In: DeVita, Hellman, Rosenberg, eds. Cancer: Principles & Practice of Oncology. Vol 2. 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005. 28. Ferrara N, et al. Nat Med 2003; 9(6): 669-676. 29. Inoue M, et al. Cancer Cell 2002; 1: 193-202. 30. Melnyk O, et al. J Urol 1999; 161: 960-963.

TE Connectivity Kissling Series 35 200A 电池断开开关说明书

KISSLINGBATTERY DISCONNECTORSeries 35 / 200A - from TE Connectivity (TE)Our manually operated battery disconnector up to 200 amps meets the most demanding requirements in all vehicle applications. The nom-inal current ratings refer to continuous DC current at up to 100% duty cycle and the switches are built to switch under full load. Our battery disconnector can handle up to five times the continuous current level for up to 10 seconds as overload current. (Overload current of 1000 amps for 30 seconds)All series 35 battery disconnectors are sealed with a technology that meets the IP67 and IP6K9K (steam preassure cleaning) standards and the switches are designed to operate at temperatures between -40°C and +85°C.Options include single or dual pole configurations, various mounting and locking (security) alternatives as well as different shapes and colors of the operating handles to serve your requirements.Battery disconnectors from our KISSLING product family are able to be operated under fall load, to ensure a safe disconnection from the battery in emergency conditions. The range also has optional protec-tion against theft or unauthorized use of vehicles or equipment by re-movable or lockable operating elements.Features• Sealed housing conforms to IP6K9K • Robust design• 6G shock and 4G vibration resistant • Main contact current rated for continu-ous current and 100% duty cycle • Battery disconnection under load in case of an emergency• Variable or scalable mounting options • Safety in the vehicle service by so called “LOCK” options (only two pole)Applications • Truck • Bus• Ground support vehicles• Construction and agricultural vehicles • Railway •AircraftSpecificationTechnical Data Temperature range -40°C to +85°C Protection IP67 / IEC 529Vibration 4g (50-2000 HZ)Shock6g, 11 msecThread sizes / Torque M8 = 12 - 13Nm | M10 = 15 - 20NmElectrical DataMin. insulation resistance 100M ΩDielectric withstanding voltage 1050V / 1 min at 50Hz Max. contact drop max. load 150 mVVoltage rangeup to 32VDC (optional up to 80VDC)Duty rating continuous 200A @ 70mm 2 / 300A @ 95mm 2Overload 500A - 180sec / 1000A - 30sec Wire section min 70mm 2 / min 95mm 2Mounting position optionalAvailable KeysKeyholderNot for switches with central mounting / optional available for 2-pole version1345Technical drawingsCircuitCircuitCircuitCircuit1-pole standard mounitng1-pole with longflange1-pole with central mounting2-poles with longflangeTE Connectivity, TE, TE connectivity (logo) and KISSLING (word) are trademarks owned or licensed by the TE Connectivity family of companies. All other logos, products and/or company names referred to herein might be trademarks of their respective owners.The information given herein, including drawings, illustrations and schematics which are intended for illustration purposes only, is believed to be reliable. However, TE Connectivity makes no warranties as to its accuracy or completeness and disclaims any liability in connection with its use. TE Connectivity‘s obligations shall only be as set forth in TE Connectivity‘s Standard Terms and Conditions of Sale for this product and in no case will TE Connectivity be liable for any incidental, indirect or consequential damages arising out of the sale, resale, use or misuse of the product. Users of TE Connectivity products should make their own evaluation to determine the suitability of each such product for the specific application.© 2020 TE Connectivity | All Rights Reserved. K1166706 | Version 08/2020Ordering InformationMounting option 1,3 and 4 also available for 1-pole version。

Anritsu Sitemaster S332D 使用说明

移动产品事业部售后文档文档名称：AnritsuSitemaster_S332D使用说明资料版本：V2006-R1.0产品版本：共20页(包括封面)拟制王延金审核标准化批准中兴通讯股份有限公司修改记录声明本资料著作权属中兴通讯股份有限公司所有。

未经著作权人书面许可，任何单位或个人不得以任何方式摘录、复制或翻译。

侵权必究。

和是中兴通讯股份有限公司的注册商标。

中兴通讯产品的名称和标志是中兴通讯的专有标志或注册商标。

在本手册中提及的其他产品或公司的名称可能是其各自所有者的商标或商名。

在未经中兴通讯或第三方商标或商名所有者事先书面同意的情况下，本手册不以任何方式授予阅读者任何使用本手册上出现的任何标记的许可或权利。

本产品符合关于环境保护和人身安全方面的设计要求，产品的存放、使用和弃置应遵照产品手册、相关合同或相关国法律、法规的要求进行。

由于产品和技术的不断更新、完善，本资料中的内容可能与实际产品不完全相符，敬请谅解。

如需查询产品的更新情况，请联系当地办事处。

前言AnritsuSitemaster_S332D是GSM-BSS重要的工具之一，本文讲述了该仪器仪表的功能、安装及使用方法。

目录第1章仪表使用指导说明 (1)1.1 仪表功能介绍 (1)1.1.1 仪表功能 (1)1.1.2 相关概念 (1)1.2 适用范围 (1)1.3 工作条件 (1)1.4 测试环境与版本 (2)1.4.1 硬件配置 (2)1.4.2 软件配置 (3)1.5 测试框图和测试流程图 (3)1.5.1 Site Master图示 (3)1.5.2 测试框图 (3)1.5.3 测试流程图 (4)1.6 测试步骤 (6)1.6.1 开机步骤 (6)1.6.2 校准 (6)1.6.3 进行线路扫描测量 (6)1.6.4 关机步骤 (11)1.6.5 测试记录表 (11)1.7 测试注意事项 (12)第1章仪表使用指导说明1.1 仪表功能介绍1.1.1 仪表功能日本Anritsu公司的Site Master B332D具有以下功能：●天线驻波比测试●部分仪表具有频谱仪功能1.1.2 相关概念1.2 适用范围●按频率测试驻波比、回波损耗●按距离测试驻波比、回波损耗1.3 工作条件⏹频率范围: 25 MHz ~ 4000MHz⏹频率精度: ≤± 75 ppm @ +25°C⏹频率分辨率: 100 kHz⏹输出功率: < 0 dBm (-10 dBm 标称值)⏹回波损耗: 范围: 0.00 ~ 60.00 dB⏹驻波比：范围：1.00 ~ 65.00⏹传输线损耗范围: 0.00 ~ 30.00 dB⏹测量精度: >42 dB 校准后⏹DTF(故障定位)：垂直范围:回波损耗: 0.00 ~ 60.00 dB驻波比: 1.00 ~ 65.00水平范围:0 －(数据点-1) X 分辨率到最大1197 m(3929 ft);数据点= 130, 259, 517⏹水平分辨率(矩形窗口内):分辨率(meter) =(1.5 x 10^8) x (Vp)/DFVp是馈线的相对传播速率DF 是终止频率-起始频率(Hz)⏹语言: 中，英，法，德，日，西班牙⏹内部曲线存储: 可达200条曲线⏹设置配置: S332D - 20, S331D - 25⏹输入和输出端口:RF 输出: N型, 阴性, 50 Ohm最大输入烧毁功率: +23dBm,±50VDCRF 输入: N型, 阴性, 50 Ohm最大输入烧毁功率: +43dBm(峰值), ±50 VDC⏹外部频率参考输入(2 ~20 MHz):共用的BNC, 阴性50Ohm,( 5dBm ~ +10dBm)(只对S332D)⏹T1/E1 (接收和发射): Bantam 插座(只对S331D,选件50)⏹串行接口: RS-232 9针D-sub, 串行3线⏹安全:符合EN 61010-1 1级便携式设备标准⏹温度:工作温度: -10°C ~ +55°C⏹湿度: 85% 或更低⏹非工作温度: -51°C ~ +71°C⏹电源外部DC输入: +12.5 ~ +15伏直流最大1350 毫安内部: 镍氢电池: 10.8伏, 1800 mAH⏹外形: 尺寸(宽x 高x 深):25.4 厘米x 17.8厘米x 6.1 厘米(10.0英寸x 7.0 英寸x 2.4 英寸)⏹重量: <2.28 kg (<5 lbs)包括电池1.4 测试环境与版本1.4.1 硬件配置（测试需要的硬件，含线缆，仪表，接头，校准头）◆Site Master一台◆2米J头N型跳线电缆一根（备用）◆KK接头一个（备用）1.4.2 软件配置仅测试无需其它软件，如需要截图提交报告，可在Site Master保存目标图像后使用SiteMaster自带的分析软件导出所需图形至PC。

Eaton 265783 型号 NZM 电子制造电路保护器说明书

Eaton 265783Eaton Moeller series NZM - Molded Case Circuit Breaker. Circuit-breaker, 3p, 550A, N, 4General specificationsEaton Moeller series NZM molded case circuit breaker electronic2657834015082657833401 mm 207 mm 210 mm 18.24 kg RoHS conformIEC IEC/EN 60947Product NameCatalog NumberEANProduct Length/Depth Product Height Product Width Product Weight Compliances Certifications550 AIs the panel builder's responsibility. The specifications for the switchgear must be observed.15 kA26 kAMeets the product standard's requirements.Is the panel builder's responsibility. The specifications for the switchgear must be observed.Built-in device fixed built-in techniqueFixed550 ADoes not apply, since the entire switchgear needs to be evaluated.Min. 6 segments of 16 mm x 0.8 mm at flat conductor terminal 10 segments of 80 mm x 1 mm (2x) at rear-side width extension Max. 10 segments of 32 mm x 1 mm (2x) at flat conductor terminal10 segments of 50 mm x 1 mm (2x) at 1-hole module plate Max. 10 segments of 50 mm x 1 mm (2x) at rear-side connection (punched)Min. 5 segments of 25 mm x 1 mm at rear-side connection (punched)Rocker leverMeets the product standard's requirements.eaton-circuit-breaker-nzm-mccb-characteristic-curve-055.epseaton-manual-motor-starters-starter-nzm-mccb-wiring-diagram.eps eaton-manual-motor-starters-starter-msc-r-reversing-starter-wiring-diagram.epseaton-circuit-breaker-nzm-mccb-dimensions-022.epseaton-circuit-breaker-switch-nzm-mccb-3d-drawing-003.epsMN4-ME550IL01210010ZDA-CS-nzm4_3pDA-CD-nzm4_3pDA-DC-03_N4Rated operational current for specified heat dissipation (In) 10.11 Short-circuit ratingRated short-circuit breaking capacity Ics (IEC/EN 60947) at 690 V, 50/60 HzRated short-circuit breaking capacity Icu (IEC/EN 60947) at 400/415 V, 50/60 Hz10.4 Clearances and creepage distances10.12 Electromagnetic compatibilityMounting MethodAmperage Rating10.2.5 LiftingTerminal capacity (copper strip)Handle type10.2.3.1 Verification of thermal stability of enclosuresAmbient storage temperature - min Characteristic curve Diagramas de cableadoDibujoseCAD model Instrucciones de instalación mCAD modelReportes de certificaciones40 °CFitted with:Thermal protectionProtection against direct contactFinger and back-of-hand proof to VDE 0106 part 100Terminal capacity (copper busbar)Min. 60 mm x 10 mm at rear-side width extensionMax. 50 mm x 10 mm (2x) direct at switch rear-side connection Min. 25 mm x 5 mm direct at switch rear-side connectionMin. 25 mm x 5 mm at rear-side 1-hole module plateMax. 80 mm x 10 mm (2x) at rear-side width extension50 mm x 10 mm (2x) at rear-side 2-hole module plateMax. 50 mm x 10 mm (2x) at rear-side 1-hole module plateM10 at rear-side screw connection10.8 Connections for external conductorsIs the panel builder's responsibility.Special featuresIEC/EN 60947-4-1, IEC/EN 60947-2 The circuit-breaker fulfills all requirements for AC-3 switching category. R.m.s. value measurement and “thermal memory” Adjustable time delay setting to overcome current peaks tr at 6 x Ir also infinity (without overload releases) All AC-3 rating data applies to direct switching by the circuit-breaker under normal operating conditions. If, for example, a contactor takes over AC-3 switching under normal operating conditions, the full rated uninterrupted current applies to the circuit-breaker, In = Iu. Maximum back-up fuse, if the expected short-circuit currents at the installation location exceed the switching capacity of the circuit breaker (Rated short-circuit breaking capacity Icn) Rated current = rated uninterrupted current: 550 AAmbient operating temperature - max70 °CClimatic proofingDamp heat, constant, to IEC 60068-2-78Damp heat, cyclic, to IEC 60068-2-30Terminal capacity (aluminum stranded conductor/cable)50 mm² - 240 mm² (4x) at 4-hole tunnel terminalTerminal capacity (copper stranded conductor/cable)50 mm² - 185 mm² (4x) direct at switch rear-side connection120 mm² - 185 mm² (1x) direct at switch rear-side connectionLifespan, electrical2000 operations at 400 V AC-32000 operations at 690 V AC-13000 operations at 400 V AC-11000 operations at 690 V AC-33000 operations at 415 V AC-12000 operations at 415 V AC-3Electrical connection type of main circuitScrew connectionShort-circuit total breaktime< 25 ms ( 415 V); < 35 ms (> 415 V)Rated impulse withstand voltage (Uimp) at main contacts8000 VRated short-circuit breaking capacity Ics (IEC/EN 60947) at 400/415 V, 50/60 Hz26 kA10.9.3 Impulse withstand voltageIs the panel builder's responsibility.Utilization categoryB (IEC/EN 60947-2)Number of polesThree-poleAmbient operating temperature - min-25 °C10.6 Incorporation of switching devices and componentsDoes not apply, since the entire switchgear needs to be evaluated.10.5 Protection against electric shockDoes not apply, since the entire switchgear needs to be evaluated.Terminal capacity (control cable)0.75 mm² - 2.5 mm² (1x)0.75 mm² - 1.5 mm² (2x)Equipment heat dissipation, current-dependent33.58 WInstantaneous current setting (Ii) - min550 A10.13 Mechanical functionThe device meets the requirements, provided the information in the instruction leaflet (IL) is observed.10.2.6 Mechanical impactDoes not apply, since the entire switchgear needs to beevaluated.10.9.4 Testing of enclosures made of insulating materialIs the panel builder's responsibility.Rated operational current544 A (400 V AC-3)550 A (690 V AC-3)Rated short-circuit breaking capacity Ics (IEC/EN 60947) at 230 V, 50/60 Hz37 kAApplicationUse in unearthed supply systems at 525 V10.3 Degree of protection of assembliesDoes not apply, since the entire switchgear needs to be evaluated.Rated short-circuit making capacity Icm at 240 V, 50/60 Hz105 kARated short-circuit breaking capacity Ics (IEC/EN 60947) at 440 V, 50/60 Hz26 kADegree of protection (IP), front sideIP40 (with insulating surround)IP66 (with door coupling rotary handle)Rated short-circuit making capacity Icm at 525 V, 50/60 Hz53 kARated short-circuit making capacity Icm at 690 V, 50/60 Hz40 kAInstantaneous current setting (Ii) - max7700 AOverload current setting (Ir) - min275 A10.2.3.2 Verification of resistance of insulating materials to normal heatMeets the product standard's requirements.10.2.3.3 Resist. of insul. mat. to abnormal heat/fire by internal elect. effectsMeets the product standard's requirements.Lifespan, mechanical10000 operationsOverload current setting (Ir) - max550 AVoltage rating690 V - 690 VTerminal capacity (copper solid conductor/cable)120 mm² - 300 mm² (1x) at rear-side 1-hole module plate300 mm² (4x) at rear-side width extension95 mm² - 240 mm² (6x) at rear-side width extension95 mm² - 185 mm² (2x) at rear-side 2-hole module plate35 mm² - 185 mm² (4x) at rear-side 2-hole module plate50 mm² - 240 mm² (4x) at 4-hole tunnel terminal95 mm² - 300 mm² (2x) at rear-side 1-hole module plateDegree of protection (terminations)IP00 (terminations, phase isolator and strip terminal)IP10 (tunnel terminal)10.9.2 Power-frequency electric strengthIs the panel builder's responsibility.Short-circuit release non-delayed setting - min1100 ADegree of protectionIP20 (basic degree of protection, in the operating controls area) IP20Overvoltage categoryIIIRated short-time withstand current (t = 1 s)19.2 kARated impulse withstand voltage (Uimp) at auxiliary contacts 6000 VTerminal capacity (aluminum solid conductor/cable)70 mm² - 185 mm² (2x) at rear-side 1-hole module plate240 mm² (2x) at rear-side width extension50 mm² (4x) at rear-side 2-hole module plate185 mm² - 240 mm² (1x) at rear-side 1-hole module plate70 mm² - 240 mm² (6x) at rear-side width extensionSwitch off techniqueElectronicRated short-time withstand current (t = 0.3 s)19.2 kAAmbient storage temperature - max70 °CRated short-circuit breaking capacity Ics (IEC/EN 60947) at 525 V, 50/60 Hz19 kAOptional terminalsConnection on rear. Strip terminal. Tunnel terminalRelease systemElectronic releasePollution degree310.7 Internal electrical circuits and connectionsIs the panel builder's responsibility.Rated operating power at AC-3, 230 V160 kW10.10 Temperature riseThe panel builder is responsible for the temperature rise calculation. Eaton will provide heat dissipation data for the devices.FunctionsMotor protectionPhase failure sensitiveShort-circuit release non-delayed setting - max7700 AStandard terminalsScrew terminalRated short-circuit making capacity Icm at 400/415 V, 50/60 Hz 105 kARated operating power at AC-3, 400 V315 kWTypeCircuit breaker10.2.2 Corrosion resistanceMeets the product standard's requirements.10.2.4 Resistance to ultra-violet (UV) radiationMeets the product standard's requirements.10.2.7 InscriptionsMeets the product standard's requirements.Rated short-circuit making capacity Icm at 440 V, 50/60 Hz74 kAIsolation500 V AC (between auxiliary contacts and main contacts)Eaton Corporation plc Eaton House30 Pembroke Road Dublin 4, Ireland © 2023 Eaton. Todos los derechos reservados. Eaton is a registered trademark.All other trademarks areproperty of their respectiveowners./socialmedia300 V AC (between the auxiliary contacts)60NZM4As required 15 g (half-sinusoidal shock 11 ms)1000 VNumber of operations per hour - max Circuit breaker frame type Direction of incoming supply Shock resistanceRated insulation voltage (Ui)。

EATON 磁区断路器两路和三路电缆接锁套具安装和卸载说明说明书

Installation and removal instructions for Magnum drawout breaker two-way and three-way cable interlock kitContentsDescription PageGeneral information . . . . . . . . . . . . . . . . . . . . . . . .2Installation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4Functional test of interlock assembly . . . . . . . . .10Instructions apply to:Magnum T series IZM and Magnum DS/SB2Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way andthree-way cable interlock kitEATON m WARNING(1) ONLY QUALIFIED ELECTRICAL PERSONNEL SHOULD BE PERMITTED TO WORK ON THE EQUIPMENT.(2) ALWAYS DE-ENERGIZE PRIMARY AND SECONDARY CIRCUITS IF A CIRCUIT BREAKER CANNOT BE REMOVED TO A SAFE WORK LOCATION.(3) DRAWOUT CIRCUIT BREAKERS SHOULD BE LEVERED (RACKED) OUT TO THE DISCONNECT POSITION.(4) ALL CIRCUIT BREAKERS SHOULD BE SWITCHED TO THE OFF POSITION AND MECHANISM SPRINGS DISCHARGED.FAILURE TO FOLLOW THESE WARNINGS FOR ALL PROCEDURESDESCRIBED IN THIS INSTRUCTION LEAFLET COULD RESULT IN DEATH, BODILY INJURY, OR PROPERTY DAMAGE.m WARNINGTHE INSTRUCTIONS CONTAINED IN THIS IL AND ON PRODUCT LABELS HAVE TO BE FOLLOWED. OBSERVE THE FIVE SAFETY RULES: – DISCONNECTING– ENSURE THAT DEVICES CANNOT BE ACCIDENTALLY RESTARTED – VERIFY ISOLATION FROM THE SUPPLY – EARTHING AND SHORT-CIRCUITING– COVERING OR PROVIDING BARRIERS TO ADJACENT LIVE PARTSDISCONNECT THE EQUIPMENT FROM THE SUPPLY. USE ONLY AUTHORIZED SPARE PARTS IN THE REPAIR OF THE EQUIPMENT. THE SPECIFIEDMAINTENANCE INTERVALS AS WELL AS THE INSTRUCTIONS FOR REPAIR AND EXCHANGE MUST BE STRICTLY ADHERED TO PREVENT INJURY TO PERSONNEL AND DAMAGE TO THE SWITCHBOARD.General informationThis information leaflet provides detailed installation instructions for installing and interconnecting one drawout Magnum T breaker to another type of low voltage circuit breaker (LVCB) in any position (see A, B, C in T able 1 and T able 2) for a two-way, three-way Type 31, or three-way Type 33 interlock configuration as shown in Figure 1 . When purchasing kits for a two-way or a three-way interlock configuration setup, additional interlock kits (the types of interlock kits and the other breakers on which they can be installed that are compatible with this kit are listed in T able 3 and T able 4) are required for the other breaker(s) as well as the interconnecting cable kits (one, two, or three are required depending on whether a two-way, three-way Type 31, or three-way Type 33 interlock configuration is desired, respectively) .For two-way and three-way interlock configurations, the mechanical interlock holds one or more of the breakers tripped or open(prevents closure) when some combination of the others are closed . A lever assembly is mounted on each breaker and interfaces with the pole shaft and trip lever . The lever assemblies areinterconnected with cables provided in interconnecting cable kits (listed in T able 5) that are compatible with this interlock kit . Thecable kits, purchased separately, each contain two cables and can be used for any orientation of the breakers according to the installation recommendations in Step 7 .Refer to Figure 2 and Figure 3 for identification of interlock kit and interconnecting cable kit contents, respectively .BC BC ABABCDC DTwo-way cable routingThree-way Type 31cable routingThree-way Type 33cable routingABC DABCDABC DFigure 1. Cable routing for two-way and three-way T ype 31 and T ype 33 interlock configurations T able 1. T wo-way interlock logicBreaker ABreaker BAllowed states or conditions 0010010 = open 1 = closed3Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way and three-way cable interlock kitEATON T able 2. T wo-way T ype 31 and T ype 33 interlock logicType 33 (six cable)Type 31 (four cable)Breaker Breaker ABCABCAllowed states or conditions 000000100100010101001001———0100 = open 1 = closedT able 3. T wo-way interlock assembly kits for interconnected breakersInterconnected breakerInterlock assembly kit for fixed breakerInterlock assembly kit for drawout breakerNRX Type NF frame IZMX-MIL2C-F16-2IZMX-MIL2C-W16-2NRX Type RF frameIZMX-MIL2C-F40-2IZMX-MIL2C-W40-2Magnum DS T , SB or IZMMCI2W3W3133FX MCI2W3W3133DOT able 4. Three-way interlock assembly kits for interconnected breakersInterconnected breakerInterlock assembly kit for fixed breakerInterlock assembly kit for drawout breakerNRX Type NF frame IZMX-MIL3133C-F16-2IZMX-MIL3133C-W16-2NRX Type RF frame IZMX-MIL3133C-F40-2IZMX-MIL3133C-W40-2Magnum DS, SB or IZM MCI2W3W3133FX MCI2W3W3133DOT able 5. Interconnecting cable kits (two cables per kit) aCable kit lengthCatalogue number1,5 m (5 ft)IZMX-MIL-CAB1520-21,8 m (6 ft)IZMX-MIL-CAB1830-22,4 m (8 ft)IZMX-MIL-CAB2440-23,0 m (10 ft)IZMX-MIL-CAB3050-2a Cable kits are purchased separately as needed.(F)Grease tube3x(B)M6 x 25 mm flathead screw1x(G)Cable bracket1x(H)M6 x 10 mm thread-forming screws2x(E)Interlock assembly1x(D)Drive arm1x(C)Lock washer3x(A)M6 x 12 mm hex bolt 3x Figure 2. Interlock kit part identification, includes parts to install on a single drawout Magnum breaker and cassette (does not include cables)4Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way andthree-way cable interlock kitEATON Figure 3. Interconnecting cable kit part identification (includes cables)Installation of two-way cable interlockRequired tools• 10 mm hex socket • 10 mm open-end wrench • 11/16-inch open-end wrench • 3/8-inch open-end wrench (2)• 4 mm Allen wrench • Drive extension • Pliers • Ratchet•Measuring instrument, in mmBefore proceeding with the following steps, ensure that all breakers are in the OPEN and DISCHARGED position .Step 1Remove the four hex-head captive bolts (six for 4-pole breaker) holding the cover in place as shown in Figure 4 . Pull down on the charginghandle (approximately 45 degrees) and remove the front cover .Figure 4. Details for Step 1Step 2Remove drive arm window as shown in Figure 5 . Either use a utility knife to cut the window from the cover, or use a punch and a small hammer to carefully punch out the window . Once the window is removed, use a small file to remove any burrs that remain . Make certain that all pieces and/or particles are cleaned up and removed before proceeding .Figure 5. Details for Step 25Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way and three-way cable interlock kitEATON Step 3Install the drive arm (D) to the end of the pole shaft using an M6 x 25 mm flat-head screw (B) . Apply Loctite T Blue 242 to ensure that the screw cannot loosen during operation . The drive arm should be oriented as shown in Figure 6 . Torque to 7,3–9,6 N∙m (65–85 in-lb) .Pole shaft(B)(D)End of pole shaftFigure 6. Details for Step 3 and 4Step 4Reinstall the front cover using the four hex-head captive bolts (six for 4-pole breaker) removed in Step 1 .Step 5Fasten the interlock assembly (E) to the drawout cassette’s right-side sheet using three M6 x 12 mm hex bolts (A) and three lock washers (C) as shown in Figure 7 . Torque to 4,5–5,6 N∙m (40–50 in-lb) .Cassette right-side sheet(E)(A)(C)Figure 7. Details for Step 5Step 6Fasten cable bracket (G) to the drawout cassette’s right-side sheetjust below the interlock assembly (mounted in Step 5) using two M6 x 10 mm thread-forming screws (H) as shown in Figure 8 . Torque to 7,3–9,6 N∙m (65–85 in-lb) . Ensure the trip paddle is behind (on the same side as the back of the breaker) the trip lever as shown in Figure 9 .(H)(G)Cassette right-side sheetFigure 8. Details for Step 6Trip paddleTrip leverFollower armDrive armFigure 9. Details for Step 66Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way andthree-way cable interlock kitEATON Step 7This step offers cable routing and installation procedures . Make sure that cables move freely in their cable housings before installation . When attaching cables to swivel fittings, ensure that both ends of the cable are connected to push swivel fittings or both ends of the cable are connected to pull swivel fittings (refer to Figure 11) . For example, a cable connected to the drive lever pull swivel fitting on Breaker A must connect to the driven level pull swivel fitting on Breaker B .ATTENTIONFIGURE 10 SHOWS THE TYPICAL CABLE ROUTING FOR TWO-WAY AND THREE-WAY TYPE 31 AND TYPE 33 INTERLOCK CONFIGURATIONS.NOTICE THAT DEPENDING ON THE POSITION OF THE BREAKER WITHIN THE INTERLOCK CONFIGURATION, THE CABLES WILL BE ATTACHED IN DIFFERENT LOCATIONS. THE CABLE MOUNTING ON BOTH SWIVEL FITTINGS OF THE DRIVE AND DRIVEN LEVERS ARE DESCRIBED BELOW. TABLE 6 SHOWS THE TWO-WAY INTERLOCK LOGIC DEPENDING ON POSITION. TABLE 7 SHOWS THE THREE-WAY TYPE 31 AND TYPE 33 INTERLOCK LOGIC DEPENDING ON POSITION.BC BC ABABC DCDTwo-way cable routingThree-way Type 31cable routingThree-way Type 33cable routingABCDABC DABCDFigure 10. Cable routing for interlock configurationsT able 6. T wo-way interlock logicBreaker ABreaker BAllowed states or conditions 0010010 = open 1 = closedT able 7. Three-way T ype 31 and T ype 33 interlock logicType 33 (six cable)Type 31 (four cable)Breaker Breaker ABCABCAllowed states or conditions 000000100100010101001001———0100 = open 1 = closed7Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way and three-way cable interlock kitEATON Installation recommendations• 102 mm (4 in) minimum allowable cable housing bend radius •Use plastic wire ties / clamps to attach cable housing to structure after installation and adjustment • Do not compress cable housing •Recheck to ensure cables move freelyDriven lever pull swivel fittingDriven lever push swivel fittingDriven leverDrive lever pull swivel fittingDrive lever push swivel fitting GapDrive lever Figure 11. Push and pull swivel fitting identificationStep 8This step describes how to first attach the drive (short rod) end of a cable to its interlock assembly and cable bracket . See Figure 12 .To attach the drive (short) end of the cable to the drive lever pull swivel fitting (refer to Figure 11), follow the directions below .1. Remove the upper nut, compression spring, and 38,1 mm(1,5 in) tube spacer from end of rod of cable assembly .2. Slide rubber boot toward tip of rod .3. Unthread outer bulkhead nut, and slide nut and lock washertoward tip .4. Insert threaded end of rod into swivel fitting .5. Slide smaller diameter portion of bulkhead fitting into cablebracket slot .6. Raise the cable assembly until threaded portion of bulkheadfitting enters slotted hole in cable bracket (threads show above bracket) .7. Bring bulkhead washer and nut down to threads andhand tighten .8. Adjust two bulkhead nuts to approximately center the bulkheadfitting on the cable mounting bracket . 9. Hand tighten the bulkhead nuts at this time .10. Slide rubber boot back into place over end of bulkhead fitting .11. Replace 38,1 mm (1,5 in) tube spacer, compression spring, andupper nut on end of rod .12. Lower nuts should be shouldered against end of thread andupper nut tightened against tube spacer .13. Hold lower nuts and torque upper nut to 3,3–4,5 N∙m (30–40 in-lb) .To attach the drive (short rod) end of a cable to the drive leverpush swivel fitting of the drive lever (refer to Figure 11), follow the directions below (see Figure 12) .1. Remove upper nut from end of rod of cable assembly .2. Slide rubber boot toward tip of rod .3. Unthread outer bulkhead nut and slide nut and lock washertoward tip .4. Insert threaded end of rod with 38,1 mm (1,5 in) tube spacerinto swivel fitting, ensuring that the compression spring remains between the lower nuts and the swivel .5. Slide smaller diameter portion of bulkhead fitting into cablebracket slot .6. Raise the cable assembly until threaded portion of bulkheadfitting enters slotted hole in cable bracket (threads show above bracket) .7. Bring bulkhead washer and nut down to threads andhand tighten .8. Adjust two bulkhead nuts to approximately center the bulkheadfitting on the cable mounting bracket . 9. Hand tighten the bulkhead nuts at this time .10. Slide rubber boot back into place over end of bulkhead fitting .11. Lower nuts should be shouldered against end of thread andupper nut tightened against tube spacer .12. Hold lower nuts and torque upper nut to 3,3–4,5 N∙m(30–40 in-lb) .8Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way andthree-way cable interlock kitEATON Figure 12. Details for Step 8: Cable assembly drive (short rod) end mounting component identification, mounting cable assembly in cable bracket, and cable rod attachment to drive arm9Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way and three-way cable interlock kitEATON Step 9This step describes how to attach the driven (long rod) end of a cable attached to an interlock assembly on another breaker to the cable bracket and interlock assembly on this Magnum breaker . Refer to Figure 10 and Figure 11 for cable routing and correct swivel fittings to which the cables are connected .The driven (long rod) end of the cable is attached to the correspond-ing push or pull swivel fitting on the driven lever on this cable interlock assembly similarly to Step 8 except the driven end does not utilize a compression spring between the swivel and nut .Remove and discard the 22,2 mm (0,875 in) cable tube spacer (K) on the rod end of the cable assembly (I) and replace it with the 38,1 mm (1,5 in) cable tube spacer (J) . Install the cable as shown in Figure 13 and Figure 14 .Upper nuts Swivel fittings 38,1 mm (1,5 in) cable tube spacer Driven end (long end)Lower nuts Rubber bootDriven end cable bracketsOuter bulkhead nutBulkhead nutFigure 13. Details for Step 9Step 10This step describes how to adjust the cables to ensure proper functionality of the cable interlock setup . Cable adjustments are made with the large bulkhead nuts ONL Y and with all breakers OPEN . Nuts on the rod ends should not be moved .Begin by adjusting or verifying that all bulkhead fittings areapproximately centered on the cable mounting brackets (center of threaded section of bulkhead), allowing for room for adjustment in either direction . Hand tighten the nuts at this time .Perform initial adjustments on the driven (long rod) end of cable . There should be a small (0–5 mm) clearance between the upper nut and the face of the driven lever pull swivel on which it pulls and between the lower nuts and the face of the driven lever push swivel on which it pushes as shown in Figure 14 .If there is too much clearance , adjust both bulkhead nuts to retract the cable housing (move threaded portion down) .If there is no clearance , advance the cable housing in the same manner (move threaded portion up) .If additional adjustment length is needed, the bulkhead nuts on the other end of cable can be used .When the proper clearance is attained on the driven end, torque the cable bulkhead nuts on both ends to 11–13 N∙m (100–120 in-lb) without moving the bulkhead fittings .After the driven end has been adjusted and the bulkhead nuts have been tightened, perform adjustments on the drive (short rod) end of the cable . Adjust the bulkhead nuts up (move threaded portion down) such that the gap between the drive lever and the interlock assembly base shown on Figure 11 is less than 4 mm .When the gap is less than 4 mm, torque the cable bulkhead nuts on both ends to 11–13 N∙m (100–120 in-lb) .Between 0 and 5 mm after adjusting cableBetween 0 and 5 mm after adjusting cableTighten these nuts before mounting driven endAdjustment nutsAdjustment nuts Cable bracketLong rodDrive lever Short rod Drive endFigure 14. Details for Steps 9 and 1010Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way andthree-way cable interlock kitEATON Functional test of interlock assemblyBegin test sequence with all breakers OPEN .T wo-way interlock configuration functional testCheck 1: CHARGE and CLOSE Breaker A• Verify that Breaker A closed using the OPEN/CLOSED indication •Inspect the driven lever on Breaker B . Check that it rotated from its initial position•CHARGE and attempt to CLOSE Breaker B . It should not respond to CLOSE attempt (no noise, spring discharge, or contact motion)•If Breaker B responds to the CLOSE attempt, then additional adjustments may be required at the cable mounting brackets (refer to Steps 8, 9, and 10)Check 2: Open Breaker A• The interlock should release•CLOSE Breaker B (if already CHARGED) . Verify that it closes using the OPEN/CLOSED indication• Breaker A should remain in the OPEN position •OPEN Breaker BRepeat Checks 1 and 2 above on Breaker B , using Breaker B as Breaker A and Breaker A as Breaker B•Verify proper operation on both breakersThe mechanical interlock is now properly installed and adjusted for the two-way interlock configuration . Use a light amount of supplied lubricant (F) if any interlock parts are sticky or do not fully reset . This is only recommended if needed .T ype 31—Four-cable interlock assembly testRefer to T able 2 for logic details .• CHARGE and CLOSE Breaker A•CHARGE and attempt to CLOSE Breaker B . It should not respond to CLOSE attempt (no noise, spring discharge, or contact motion)•CHARGE and CLOSE Breaker C . Verify that Breaker C closes using the OPEN/CLOSED indication and that Breaker A remains CLOSED•CHARGE and attempt to CLOSE Breaker B again . It should still not respond to CLOSE attempt (no noise, spring discharge, or contact motion)•OPEN Breaker A . Verify that Breaker C is still CLOSED . CHARGE and attempt to CLOSE Breaker B . It should still not respond to CLOSE attempt (no noise, spring discharge, or contact motion)• OPEN Breaker C . All breakers should now be OPEN•CHARGE and CLOSE Breaker B . CHARGE and attempt to CLOSE Breakers A and C . Verify that they do not respond to CLOSE attempt (no noise, spring discharge, or contact motion)The mechanical interlock is now properly installed and adjusted for the three-way Type 31 interlock configuration . Use a light amount of supplied lubricant (F) if any interlock parts are sticky or do not fully reset . This is only recommended if needed .T ype 33—Six-cable interlock assembly testRefer to T able 2 for logic details .• CHARGE and CLOSE Breaker A•CHARGE and attempt to CLOSE Breakers B and C . Verify that neither breaker responds to CLOSE attempt (no noise, spring discharge, or contact motion)•OPEN Breaker A . The interlock should release•Repeat above test on Breakers B using B for A , C for B , and A for C and Breaker C using C for A , A for B , and B for CThe mechanical interlock is now properly installed and adjusted for the three-way Type 33 interlock configuration . Use a light amount of supplied lubricant (F) if any interlock parts are sticky or do not fully reset . This is only recommended if needed .Figure 15. Functional test gap checks11Instruction Leaflet IL0131082ENEffective April 2015Installation and removal instructions for Magnum drawout breaker two-way and three-way cable interlock kitEATON Eaton1000 Eaton Boulevard Cleveland, OH 44122 United StatesEaton .com© 2015 EatonAll Rights ReservedPrinted in USAPublication No . IL0131082EN / Z16558 Part Number: IL0131082ENH02April 2015Eaton is a registered trademark.All other trademarks are propertyof their respective owners. Installation and removal instructions for Magnum drawout breaker two-way andthree-way cable interlock kitInstruction Leaflet IL0131082ENEffective April 2015Disclaimer of warranties and limitationof liabilityThe information, recommendations, descriptions, and safety notations in this document are based on Eaton’s experience and judgment, and may not cover all contingencies . If further information is required, an Eaton sales office should be consulted .Sale of the product shown in this literature is subject to the terms and conditions outlined in appropriate Eaton selling policies or other contractual agreement between Eaton and the purchaser .THERE ARE NO UNDERSTANDINGS, AGREEMENTS, WARRANTIES, EXPRESSED OR IMPLIED, INCLUDING WARRANTIES OF FITNESS FOR A PARTICULAR PURPOSE OR MERCHANTABILITY, OTHER THAN THOSE SPECIFICALL Y SET OUT IN ANY EXISTING CONTRACT BETWEEN THE PARTIES . ANY SUCH CONTRACT STATES THE ENTIRE OBLIGATION OF EATON . THE CONTENTS OF THIS DOCUMENT SHALL NOT BECOME PART OF OR MODIFY ANY CONTRACT BETWEEN THE PARTIES .In no event will Eaton be responsible to the purchaser or user in contract, in tort (including negligence), strict liability or otherwisefor any special, indirect, incidental or consequential damage or loss whatsoever, including but not limited to damage or loss of use of equipment, plant or power system, cost of capital, loss of power, additional expenses in the use of existing power facilities, or claims against the purchaser or user by its customers resulting fromthe use of the information, recommendations and description contained herein .The information contained in this manual is subject to change without notice .。

紫杉类抗肿瘤药物特点及临床合理应用

在没有常规承受G-CSF的病人中，中性粒细胞减少是最常见的血液学不良反响
在多西他赛用药后平均8天，中性粒细胞计数降到最低点(400/mm3)
可对逆于及中性非粒蓄细胞积的性下降的，可以采取G-CSF预防性用药
很少并发感染及发热
非血液学不良反响
紫杉醇
多西他赛
过敏反响
过敏反响
心血管毒性
皮肤及皮下组织异常
紫杉类药物药理作用机制
星状体微管束
3’位与 β-tubulin N末端的1-31氨基酸残基结合 2位与β-tubulin 217-233氨基酸结合 7位与β-tubulin Arg282结合
He LF, Orr GA, Horwitz SB drug Discovery Today 2001 :1153
紫杉醇研发过程
年代
进
展
1958
NCI开始大规模植物药研发筛选
1967
发现紫杉醇抗癌活性
1968
从红豆杉中分离出紫杉醇
1971
完成结构鉴定
1979
发表作用机制
1983
临床Ⅰ试验
1985
临床II期
1991
临床III期
1992
FDA批准上市
national cancer institute 〔NCI〕〕
应
、心动过缓等，但通
常不用治疗）
5. 肌痛、关节痛胃肠道反应，口腔皮肤质体
1.骨髓抑制:严重粒缺达47%
2.外周神经毒：62%，严重达6%
3.过敏反应：潮红、皮疹、呼吸困难、低血压、心动过速。曾发生过敏禁用。
4.心血管毒：低血压、心动过缓肌肉关节疼痛。，呈剂量依赖型。
溶剂型紫杉醇促使循环中胶束的形成

参附注射液临床应用的文献梳理

参附注射液临床应用的文献梳理柏冬;刘丽梅;岳广欣;王瑞海【摘要】目前参附注射液在临床中广泛应用,本文拟对文献报道中参附注射液的临床适应症及其联合用药情况进行梳理.本文以"参附注射液"为检索词,检索中国期刊全文数据库涉及参附注射液的临床使用报道,共检索文献719篇,共涉及疾病104种,例如心力衰竭、肺源性心脏病、心肌梗死、休克、心律失常、冠心病等疾病.其中单独使用参附注射液治疗文献519篇,涉及疾病76种,联合其他药物治疗文献200篇,涉及疾病54种.希望通过本文为参附注射液的临床使用提供指导.【期刊名称】《环球中医药》【年(卷),期】2014(007)001【总页数】5页(P68-72)【关键词】参附注射液;临床应用;单独使用;联合用药【作者】柏冬;刘丽梅;岳广欣;王瑞海【作者单位】100700,北京,中国中医科学院中医基础理论研究所;100700,北京,中国中医科学院中医基础理论研究所;100700,北京,中国中医科学院中医基础理论研究所;100700,北京,中国中医科学院中医基础理论研究所【正文语种】中文【中图分类】R605.975参附注射液由红参、黑附片的提取物组成，该品种收载于卫生部药品标准中药成方制剂第十八册中，为内科用药，属于温里剂中的回阳救逆剂。

自1983年开始有临床报道以来[1]，发表了大量关于参附注射液的临床使用文献，涉及疾病种类较多。

为了明确参附注射液的临床适应症及其使用方法，为其临床应用提供指导，本文采用文献学方法，对目前有关参附注射液临床使用的文献进行梳理。

1.1 资料来源以“参附注射液”为检索主题词，在中国学术期刊网络出版总库中检索自建国以来的全部文献，将文献信息导入医学文献王3.0中。

1.2 文献的纳入、分类及排除文献的纳入标准：所有涉及参附注射液临床使用报道的文献。

文献的排除标准：排除所有参附注射液动物药理实验文献、综述文献、临床医案文献、Meta分析类文献、临床病例数小于10例的文献、参附注射液非主要治疗药物、参附注射液为对照药物类文献。

常见抗肿瘤药物储存配置使用注意事项

根据患者用药史,依据使用时间,药代动力学特点等进行排查，考虑丙戊酸钠和左乙拉西坦两者关联最大。

从时间相关性看，患者用药-天后出现不良反应，丙戊酸钠片药物的半衰期为4~4h,连续服药3~4天后药物的血药浓度达到稳态42,左乙拉西坦半衰期为6~3h0日9次用药9天后达到稳态坪浓度〔-,存在时间合理性。

单一药物长期治疗脑卒中后癫痫的效果不理想,左乙拉西坦作为新型抗癫痫药物高生理利用度和低蛋白结合率，治疗癫痫具有一定优势4-，上市前临床研究表明服用本品并不影响其他已有的抗癫痫药物血药浓度;而且这些抗癫痫药的应用也不影响本品的药代动力学特性⑷。

皮疹是左乙拉西坦最常见的不良反应之一。

丙戊酸可引起皮肤反应4-，如皮疹。

在某些病例有毒性上皮坏死溶解，StevenDohnse综合征，多形性红斑也有报导，符合已知不良反应类型。

大疱性表皮松解型药疹是最严重的不良反应之一,严重且可能危及生命〔-。

大多数大疱性表皮松解型药疹并没有特异性治疗。

多采用支持治疗，包括伤口处理、控制感染、营养支持以及预防和治疗并发症3-。

因此，早期的识别非常重要，临床药师应该始终保持高度的警惕性，一旦发生药疹早发现，早治疗。

参考文献[1-齐庆华，王红霞,王佳虹.丙戊酸钠与左乙拉西坦治疗小儿癫痫的临床疗效分析4〕.当代医学,263,25(4)9306.〔2〕陈娇,刘晓鸣，岳璇.左乙拉西坦添加治疗对难治性癫痫患儿外周血多药耐药相关蛋白32表达的影响〔J〕.中华实用儿科临床杂志963,34(24)：1757-1740.4〕王艳0长晓鑫，杨清成•脑卒中后癫痫的临床治疗及效果研究3〕北方药学96405(4)：3899.3〕张晓毅S午莉，常凯琴.丙戊酸钠致不良反应46例临床分析中国疗养医学3〕263,8(5)：279O75.4〕张志清0长燕梅，胡永福•药源性剥脱性皮炎分析3-.中国医院药学杂志,501,46)：4403.3〕El Hachem M,Zamdruac G,BouPon-Lanoy Ept ai.MulPcentre consensus ucommeuUatUus for skis core is inhedteU epiSermolysis dullc-sa J〕Ophanet J Rare DO,2910,9：96.-经营与管理*常见抗肿瘤药物储存配置使用注意事项荆文荣、，，杨春松、，，高山、，，王叶立、，，曹芝菡、，，周庆22，许群芬、宀(1.四川大学华西第二医院药学部/循证药学中心，四川成都619061；2.四川大学出生缺陷与相关妇儿疾病教育部重点实验室，四川成都619061-摘要：整理分析我院常见静脉用抗肿瘤药物，从药物储存、配置、使用角度阐述静脉用抗肿瘤药物的注意事项，确保疗效和用药安全，为临床安全用药提供依据，体现药学服务的价值。

2021 Larson 7500G 组合货运电缆卧载器 - 电信版说明书

equals a significant increase in production and decreases downtime
LEVEL WINDER The Level Winding Device accessory is operated through the auxiliary hydraulics provided by the trailer. It holds any wire or cable in place. This device will guide wire onto the reel in a level fashion, preventing high and low spots. Not designed to be used in the fiberoptic handling process, but mainly used when
THREE POSITION, TELESCOPIC REAR REEL LOADER ARMS REEL CAPACITY: UP TO 60” WIDE, 120” TALL AND 7,500 LB. MAXIMUM
TWIN HYDRAULIC RIM DRIVE WHEELS 1 - REEL ARห้องสมุดไป่ตู้OR
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FOR OPERATING HYDRAULIC TOOLS, AND A HAND BRAKE ON THE REEL TURNING AXLE AND A WOOD DECK. THIS TRAILER HAS A 7,500 LB. PAYLOAD CAPACITY AND IS EQUIPPED WITH TWO 6,000 LB. DEXTER TORFLEX AXLES AND

Trumpf吊塔使用手册中英文对照版

Ceiling-mounted pendantsTRUMPF吊塔使用手册User Manual目录目录1 概述 (1)1.1正确使用仪器设备..........................1-22 吊塔的使用 (3)2.1试运转 (3)2.2水平移动 (3)2.2.1 正确的操作指导...........................4-6 2.3气动刹车. (7)2.4 垂直移动.................................8-10Important Information 概述概述正确使用仪器设备TRUMPF KREUZER 医疗系统产品按DIN ISO 9001标准进行开发、设计、推广.保证了产品具有以下特点：- 品质高标准，经久耐用.- 操作简便.- 功能化设计.- 最优化配置.产品符合MPG 要求，取得CE 认证.使用产品时，请认真阅读使用手册.TRUMPF KREUZER 吊塔可以承载医疗设备.其中已配置有电源和医用气体.吊塔可停放在其活动范围内的任何位置，以达到最广泛的使用.吊塔的负载设计有一定的承载能力.超过设计限度则会引起轴承及吊塔的损坏.甚至影响到使用者的人身安全.1Important Information Products of the TRUMPF KREUZER Medizin Systeme GmbH + Co. KG are manufactured to give a long and trouble-free service life. Development, design and production by TRUMPF KREUZER Medizin Systeme GmbH + Co. KG have been certified in accordance with DIN ISO 9001 and EN 46001.This guarantees:•highest quality and a long service life,•easy operation,•functional design and •optimisation for the intended purpose.The products fulfil the requirements of the Medizinproduktegesetz MPG (Law on Medical Products) and bears the CE sign.Please read this user manual carefully from the beginning, in order to familiarise yourself step-by-step with the many and variedfunctions.The ceiling-mounted pendants can be used safely!Reference is made to any residual dangers at the appropriate points in the manual. Please observe the following instructions!1.1Proper use of the equipment TRUMPF KREUZER-ceiling-mounted support-systems are used to hold medical equipment.Electric cables and hoses for medical gases are installed in the ceiling-mounted support-systems as far as a plug connection on the support-system head to supply this equipment. The equipment can then be plugged in using a short lead. This largely rules out the risk of cables trailing down.Instruments and accessories can be placed on or secured to surfaces provided for this purpose.The support-system head can be positioned anywhere in the room within the movement range to allow the user to work under ergonomic conditions.The ceiling-mounted support-system is designed to accommodate a certain load. If this load is exceeded, the support-system, and particularly the bearings, may be damaged and also adopt a skew position. However, there is no risk of fracture.In the case of manually height-adjustable ceiling-mountedsupport-systems with balancing system, the ability to operate these deteriorates if the agreed set load is exceeded or not met and may be dangerous both for the user and the equipment.Important Information 概述1.2Explanation of symbols 标识说明危险！注意！小心！提示！有严重的危及生命和损坏仪器的风险.有伤害人体和损坏器械的危险.有损坏器械的风险.信息提示.Risk of serious injuries and damage to property.ATTENTION!Risk of damage to property.Useful additional information and tips.Using the ceiling-mounted support-system吊塔的使用吊塔的使用任何时候移动吊塔，都要确保人员的安全.不允许发生未刹车而引起的碰撞事件.这些操作指导和使用TRUMPF KREUZER 公司吊塔相关.要使用吊塔上的设备，需遵循制造商的指导和规范.吊塔方可使用！移除危险标记！使用前，需做好一切准备.提示！注意！2Using the ceiling-mounted support-system 2.1Commissioning 试运转Before commissioning, the …preparations for commissioning“ described must have been carried out completely.Other regulations relating to health and safety, accidentprevention, hygiene, etc. and also relevant medical and workplaceinstructions must also be followed.damaged!Do not allow unbraked collisions with internalstops to occur!KREUZER ceiling/wall-mountedsupport-systems. To use the equipment on thesupport-system, follow the specific instructions of themanufacturer!危险！be commissioned!Only then may warning notices and signs beremoved!注意！support-system either directly or indirectly mustbe trained!Using the ceiling-mounted support-system 吊塔的使用2.2Horizontal movements 水平移动2.2.1Ergonomically correct operation 正确的操作指导•Hold the equipment rail with both hands. 双手抓住平台的边轨.•Using the thumb to operate any brake button to release thebrakes. 用拇指来操作刹车系统•The support-system head must always be moved in thefollowing directions:吊塔移动必须符合以下情况:- 远离身体，用手臂推动.(A1方向) - 用手臂拉向身体方向.(A2方向) - 侧向转动.(B方向)距离太大时，可向前或向后移动.- away from the body by pushing with the arms (direction A1) - towards the body by pulling with the arms (direction A2)- sideways (direction B) by turning.- 不要推吊塔的箱体边侧！- 注意合理用力，以防肌肉拉伤！With bigger distances, it may be necessary to move forwards and backwards.Wrong! 不当的操作！Do not push the support-system head sideways!More effort is needed and you may pull a muscle!Correct! 正确的操作！Turn the support-system head.旋转吊塔箱体.Using the ceiling-mounted support-system吊塔的使用单臂吊塔吊塔箱体移动范围为一个圆形区域吊塔从位置a 移动到位置 b.仪器平台与臂之间正好有一个合适的角度.旋转手臂到准确的位置，仍保持90°位置.(位置[b ])- 如果距离小，只需推或拉 (位置[c ])- 如果距离大，只需向前或向后轻微的移动手臂.运动范围-图1运动范围-图21 arm support-system Support-system head moves in a circular plane Movement stage 1:Turn support-system head from position [a] to position [b] so that the support-system head is more or less at right-angles to the arm.Movement stage 2:Swivel the arm to the right position, maintaining the 90° position(position [b])•for smaller distances, by pushing or pulling (position [c])•for bigger distances, by moving forwards or backwards with thearms slightly bent (position [d])Using the ceiling-mounted support-system 吊塔的使用2 arm support-systems双臂吊塔Support-system head moves in a circular plane 吊塔箱体的移动范围是Movement stage 1:运动进程 1:旋转至 90°的位置-如下图所示.Bring support-system head to 90° position, as described under "1arm support-systems".Movement stage 2:运动进程 2:围绕中心旋转下臂，直到两臂间大于90°，就可实现完美180°旋转从[e]-[f].Swivel the lower arm around the centre joint until the angle between the lower and upper arm is greater than 90°, ideally 180° ([e]->[f]) to achieve the biggest possible lever arm.Movement stage 3: 运动进程 3:运动进程 3:向前向后旋转上面的臂，以达到所要求合适的位置[g],可直接旋转吊塔箱体以达到所需的位置[hSwivel the upper arm by walking backwards or forwards. After reaching the required position [g], turn the support-system head to the required position [h].Using the ceiling-mounted support-system吊塔的使用气动刹车可使吊塔移动操作变得简便.服务部门可以根据顾客的要求，更换各种型号的气动刹车.气动刹车可帮助避免吊塔箱体发生不受控的活动，可以使它的到指定的位置.在运动的过程中,不能使用刹车.而在释放刹车前不能强行搬动吊塔,否则会导致刹车磨损甚至损坏.释放刹车是通过按压控制面板上相应的按钮.按往下的按钮直至运动终止.以下的标识分别为哪个按钮控制哪个刹车.如果刹车操作失败(听不见气声)，请检查压缩空气装置.当你释放气动刹车时，你会听到气声.这个声音表示气动刹车已释放.顶部刹车:中部刹车:底部刹车:提示！2.3Pneumatic brakes 气动刹车Pneumatic brakes make it easier to move the support-system head.The service department can retrofit ceiling-mounted support-systems with pneumatic brakes if required.Pneumatic brakes help to prevent accidental movements of thesupport-system head and hold the head in the required position.Operation: 操作方法The brake is released by pressing the corresponding button on the control panel. The button must be held down until the end of the movement. The symbols indicate which button operates which brake.Upper joint:Intermediate joint:Lower joint:You will automatically hear the air when you release the brake.This noise signals the release of the brake.注意！releasing the brake, as the brake may wear or even become defective!Using the ceiling-mounted support-system 吊塔的使用2.4Vertical movements 垂直移动Working or parking position. 工作或停止位内操作.把吊塔置于最高位置，使吊塔的箱体不低于2000mm.这样可保证不会碰到头及受伤.绝不能挂在箱体上.比如，拽拉吊塔至工作位置.防撞边角可防止头部被撞破.支持3种垂直模式：- 负载/重量- 垂直移动- 带平衡系统，不带垂直移动刹车. ->无按钮.在上下移动吊塔箱体时，有一些轻微的阻力是正常现象。

PDTC联合泰素帝对SGC-7901人胃癌细胞抑制效应及其机制

PDTC联合泰素帝对SGC-7901人胃癌细胞抑制效应及其机制谷晓媛;张为强;林万隆【摘要】目的研究PDTC合并泰素帝对SGC-7901人胃癌细胞的抑制效应及其机制.方法应用MTT法观察PDTC及泰素帝对SGC-7901细胞的增殖抑制效应,采用流式细胞术检测不同处理后SGC-7901细胞凋亡率的变化,采用实时荧光定量PCR 法测定c-IAP2及XIAP基因表达的改变,采用Western印迹法检测NF-κB P65、I-κB蛋白表达的改变.结果 PDTC组、泰素帝组及联合用药组的细胞活力都明显比对照组降低(P＜0.05),与相应的泰素帝组相比,联合用药组降低明显(P ＜0.01);PDTC、泰素帝及联合用药组的凋亡率高于对照组(P＜0.01),联合用药组细胞凋亡率明显升高,达到29.37％,与泰素帝及PDTC单药组相比,差异有统计学意义(P ＜0.05);PDTC组XIAP及c-IAP2 mRNA表达较对照组下降,泰素帝组XIAP及c-IAP2 mRNA表达较对照组升高,联合用药组XIAP及c-IAP2 mRNA表达较对照组、泰素帝组明显下降(P＜0.01);泰素帝处理后胞核NF-κB P65含量增加(P＜0.01),而PDTC联合作用后胞浆及胞核NF-κB P65含量较泰素帝组及对照组明显降低(P＜0.01).结论泰素帝与PDTC均能抑制SGC-7901细胞增殖,诱导细胞凋亡,其机制可能与PDTC可拮抗泰素帝的NF-κB激活、抑制其下游凋亡抑制蛋白基因表达有关.【期刊名称】《同济大学学报（医学版）》【年(卷),期】2014(035)002【总页数】6页(P33-38)【关键词】泰素帝;胃肿瘤;PDTC;SGC-7901;核因子-κB;凋亡抑制蛋白【作者】谷晓媛;张为强;林万隆【作者单位】上海市闸北区市北医院肿瘤专科,上海200435;上海市闸北区市北医院肿瘤专科,上海200435;上海市闸北区市北医院肿瘤专科,上海200435【正文语种】中文【中图分类】R735.2胃癌是威胁人类健康的常见恶性肿瘤之一，患病率和死亡率位居我国城市的第2位，农村的第1位［1］。

常用静脉药物的应用与注意事项(1)

常用静脉药物的应用与注意事项
邯郸市中心医院
乳腺外科赵宁
内容要点
静脉用药配伍注意事项
静脉药物的配臵
药物输注速度的控制抗菌药物的静脉应用抗肿瘤药物静脉应用中药注射剂静脉应用
静脉用药配伍注意事项
1.新药使用前，应认真阅读使用说明书。 2.在不了解其他药物对某药的影响时，应单独使用。 3.两种药混合时，一次只加一种药到输液中，混匀后液体外观无异常再加另一种药物。有色药液最后加入输液中。 4.执行注射器单用。 5.根据药物性质合理选择溶媒，避免发生理化反应。 6.合理安排输液顺序，对存在配伍禁忌的两组药液序贯给药时，应以葡萄糖或生理盐水冲洗输液管道。

病例8 患者,男,33岁, 因支原体感染给予5%葡萄糖注射液500ml+乳糖酸红霉素0.9g静点,当输入约 25分钟时,局部微痛、自感胀,肉眼观察局部无明显改变。随药液输注,局部肿胀痛渐加重,当输入1 小时50分钟时,患者自行调快滴速,60滴/分,约输入400ml时,手背、前臂、上臂均有不同程度肿胀, 疼痛加剧,遵医嘱撤下静点。经理疗后,约5天肿痛症状消失,预后佳。病例9 1患者静滴红霉素时，自行放快速度,红霉素0.9g加入500ml液体在1h内滴入后出现上肢肿胀, 随后逐渐出现个别手指活动受限及桡侧肌肉萎缩。

抗菌药物的静脉应用
（三）氨基糖苷类（链霉素阿米
卡星庆大霉素奈替米星依替米星等）
不宜与青霉素类或头孢菌素类混合静
滴。会增加肾毒性
与其它氨基糖苷类的药物（肾毒性及耳毒性药物）合用或先后连续应用，肾毒性或耳毒性增加。
抗菌药物的静脉应用
（四）四环素类（四环素土霉素多
西环素米诺环素等）

PIVAS不合理化疗用药分析与干预

PIVAS不合理化疗用药分析与干预何抒帆;陈奇【摘要】目的评价我院静脉配置中心(PIVAS)抗肿瘤药配置的不合理医嘱,为提高化疗合理用药水平提供参考.方法依据药品法定说明书及《中国药典》等相关药学资料,我院肿瘤中心2010年11月-2012年2月静脉配置化疗医嘱进行审核,并归类、汇总分析.结果审核出不合理用药医嘱共362组.不合理医嘱的主要问题为溶媒用量不当(占37.3％)、溶媒选择不当(占15.7％)、给药剂量不当及其他不合理医嘱(药物规格选择不当及缺药、电脑录入错误等).结论临床医生化疗用药存在不合理情况,药师认真审核医嘱及进行干预十分必要.药师在PIVAS审方工作方面需建立起合理用药规范,与临床医护人员共同讨论用药方案,从而提高全院的合理用药水平.%Objective Through evaluating irrational medical advices of antitumor drugs checked by pharmacists in pharmacy intravenous admixture services (PIVAS) ,in order to provide a reference for optimal application of chemotherapeutic drugs. Methods According to the drug legal instruction, Chinese Pharmacopoeia and other related pharmaceutical information, the chemotherapy medical advices from November 2010 to February 2012 were classified, summarized and analyzed in PIVAS of Guangdong General Hospital. Results 362 groups of irrational medical advices were discovered. The main problems included unsuitable solvent volume (37.3% ), unsuitable solvent selection ( 15.7% ) .unsuitable drug dosage,and others such as inappropriate drug specification selection, drug shortage and wrong operation. Conclusion The situation of irrational drug use exists in application of chemotherapy medication. Thereby, it is essential forpharmacists to check medical advices, establish rational drug use norms in PIVAS,and discuss the medication regimen with clinical staffs.【期刊名称】《广东药学院学报》【年(卷),期】2012(028)006【总页数】4页(P657-660)【关键词】静脉配置中心;化疗用药;不合理用药;干预【作者】何抒帆;陈奇【作者单位】广东省人民医院/广东省医学科学院药学部,广东广州510080;广东省人民医院/广东省医学科学院药学部,广东广州510080【正文语种】中文【中图分类】R595.3静脉配置中心(pharmacy intravenous admixture services，PIVAS)是指在符合GMP标准，依据药物特性设计的操作环境下，通过审核的处方由受过专门培训的药师严格按照标准操作程序进行包括全静脉营养、细胞毒性药物和抗生素等静脉用药物的配置，为临床药物治疗与合理用药服务的机构[1]。

超药品说明书用药备案(2018年12月)

宫颈癌（二线治疗）食管癌
小细胞肺癌卵巢上皮癌胃癌化疗，联合5-氟尿嘧啶和顺铂食管癌
10
紫杉醇
进展期卵巢癌的一线和后继治疗。淋巴结阳性的乳腺癌患者在含阿霉素标准方案联合化疗后的辅助治疗。注射液转移性乳腺癌联合化疗失败或者辅助化疗六个月内复发的乳腺癌患者。非小细胞肺癌患者的一线治疗。 AIDS相关性卡氏肉瘤的二线治疗
3 4
奈达铂异环磷酰胺
粉针注射液ຫໍສະໝຸດ 5替莫唑胺6
氟尿嘧啶
本品用于治疗：新诊断的多形性胶质母细胞瘤，开始先与放疗联合治疗，随后作为辅助胶囊转移性恶性黑色素瘤治疗。常规治疗后复发或进展的多形性胶质母细胞瘤或间变性星形细胞瘤。本品的抗瘤谱较广，主要用于治疗消化道肿瘤，或较大剂量氟尿嘧啶治疗绒毛膜上皮癌头颈部鳞癌全身化疗及注射液。亦常用于治疗乳腺癌、卵巢癌、肺癌、宫辅助化疗颈癌、膀胱癌及皮肤癌等。非霍奇金淋巴瘤外周T细胞淋巴瘤肉瘤本品可用于治疗以下疾病：局部晚期或已转移的非小细胞肺癌；子宫颈癌局部晚期或已转移的胰腺癌；吉西他滨与紫杉醇联合，可用于治疗经辅助晚期卵巢癌，联合卡 /新辅助化疗后复发，不能切除的、局部复铂，治疗在以铂类药物发或转移性乳腺癌。除非临床上有禁忌，否为基础的治疗后至少6个则既往化疗中应使用过蒽环类抗生素。月复发的患者不能手术切除或伴有转移的进展期胆管癌头颈部癌
24
氨溴索
注射液
25
普萘洛尔
片剂
26
万古霉素
粉针
明书用药备案（2018年12月）
超说明书内容具体用法 85mg/m2 依据以及参考文献 1.FDA说明书-超适应症用法 2.结直肠癌NCCN指南2016 version2 1.美国FDA未批准奥沙利铂用于食管癌、胃癌、结肠癌的辅助化疗，胆道恶性肿瘤及淋巴瘤的二线治疗 2.NCCN临床实践指南.胃癌（2015.V3） 3.NCCN临床实践指南.食道癌和胃食管交界处癌（2014.V1） 4.NCCN临床实践指南.肝胆肿瘤癌（2015.V2） 5.NCCN临床实践指南.直肠癌（2015.V2） 1.美国FDA未批准卡铂用于非小细胞肺癌的治疗 2.NCCN临床实践指南：非小细胞肺癌指南（2016. v4.0) 1.美国FDA未批准卡铂用于胸膜间皮瘤的治疗 2.NCCN临床实践指南：恶性胸膜间皮瘤指南（2016. v1.0)》 1.美国FDA未批准卡铂用于转移性乳腺癌的治疗 2.NCCN临床实践指南：乳腺癌指南（2016. v1.0)》

威勒特型号SA315警示器发音器安装指南-2010-2012版福特泰 rings说明书

Page 1©2011 Whelen Engineering Company Inc.Form No.14451C (120715)Installation Guide:SA315 Siren Speaker Mounting Bracket2010 - 2012 Ford TaurusA u t o m o t i v e : S i r e n s /S w i t c h e sFor warranty information regarding this product, visit /warrantyDANGER! Sirens produce extremely loud emergency warning tones! Exposure to these tones without proper and adequate hearing protection, could cause ear damage and/or hearing loss! The Occupational Safety & Health Administration () provides information necessary to determine safe exposure times in Occupational Noise Exposure Section 1910.95. Until you have determined the safe exposure times for your specific application,operators and anyone else in the immediate vicinity should be required to wear an approved hearing protection device. Failure to follow this recommendation could cause hearing loss!•Proper installation of this product requires the installer to have a good understanding of automotive electronics, systems and procedures.•Whelen Engineering requires the use of waterproof butt splices and/or connectors if that connector could be exposed to moisture.•Any holes, either created or utilized by this product, should be made both air- and watertight using a sealant recommended by your vehicle manufacturer.•Failure to use specified installation parts and/or hardware will void the product warranty.•If mounting this product requires drilling holes, the installer MUST be sure that no vehicle components or other vital parts could be damaged by the drilling process. Check both sides of the mounting surface before drilling begins. Also de-burr the holes and remove any metal shards or remnants. Install grommets into all wire passage holes.•If this manual states that this product may be mounted with suction cups, magnets, tape or Velcro®, clean the mounting surface with a 50/50 mix of isopropyl alcohol and water and dry thoroughly.•Do not install this product or route any wires in the deployment area of your air bag. Equipment mounted or located in the air bag deployment area will damage or reduce the effectiveness of the air bag, or become a projectile that could cause serious personal injury or death. Refer to your vehicle owner’s manual for the air bag deployment area. The User/Installer assumes full responsibility to determine proper mounting location, based on providing ultimate safety to all passengers inside the vehicle.•For this product to operate at optimum efficiency, a good electrical connection to chassis ground must be made. The recommended procedure requires the product ground wire to be connected directly to the NEGATIVE (-) battery post (this does not include products that use cigar power cords).•If this product uses a remote device for activation or control, make sure that this device is located in an area that allows both the vehicle and the device to be operated safely in any driving condition.•It is recommended that these instructions be stored in a safe place and referred to when performing maintenance and/or reinstallation of this product.•FAILURE TO FOLLOW THESE SAFETY PRECAUTIONS AND INSTRUCTIONS COULD RESULT IN DAMAGE TO THE PRODUCT OR VEHICLE AND/OR SERIOUS INJURY TO YOU AND YOUR PASSENGERS!CAUTIONLoud siren noise can cause hearing damage and/or loss.Refer to OSHA Section 1910.95prior to putting ANY siren into service!Wear Protection!ACTIVATION OF THIS SIREN MAY DAMAGE UNPROTECTED EARS!Warnings to InstallersWhelen’s emergency vehicle warning devices must be properly mounted and wired in order to be effective and safe. Read and follow all of Whelen’s written instructions when installing or using this device. Emergency vehicles are often operated under high speed stressful conditions which must be accounted for when installing all emergency warning devices. Controls should be placed within convenient reach of the operator so that they can operate the system without taking their eyes off the roadway. Emergency warning devices can require high electrical voltages and/or currents. Properly protect and use caution around live electrical connections.Grounding or shorting of electrical connections can cause high current arcing, which can cause personal injury and/or vehicle damage, including fire. Many electronic devices used in emergency vehicles can create or be affected by electromagnetic interference. Therefore, after installation of any electronic device it is necessary to test all electronic equipment simultaneously to insure that they operate free of interference from other components within the vehicle. Never power emergency warning equipment from the same circuit or share the same grounding circuit with radio communication equipment. All devices should be mounted in accordance with the manufacturer’s instructions and securely fastened to vehicle elements of sufficient strength to withstand the forces applied to the device. Driver and/or passenger air bags (SRS) will affect the way equipment should be mounted. This device should be mounted by permanent installation and within the zones specified by the vehicle manufacturer, if any. Any device mounted in the deployment area of an air bag will damage or reduce the effectiveness of the air bag and may damage or dislodge the device. Installer must be sure that this device, its mounting hardware and electrical supply wiring does not interfere with the air bag or the SRS wiring or sensors. Mounting the unit inside the vehicle by a method other than permanent installation is not recommended as unit may become dislodged during swerving; sudden braking or collision. Failure to follow instructions can result in personal injury. Whelen assumes no liability for any loss resulting from the use of this warning device. PROPER INSTALLATION COMBINED WITH OPERATOR TRAINING IN THE PROPER USE OF EMERGENCY WARNING DEVICES IS ESSENTIAL TO INSURE THE SAFETY OF EMERGENCY PERSONNEL AND THE PUBLIC.Warnings to UsersWhelen’s emergency vehicle warning devices are intended to alert other operators and pedestrians to the presence and operation of emergency vehicles and personnel. However, the use of this or any other Whelen emergency warning device does not guarantee that you will have the right-of-way or that other drivers and pedestrians will properly heed an emergency warning signal. Never assume you have the right-of-way. It is your responsibility to proceed safely before entering an intersection, driving against traffic, responding at a high rate of speed, or walking on or around traffic lanes. Emergency vehicle warning devices should be tested on a daily basis to ensure that they operate properly. When in actual use, the operator must ensure that both visual and audible warnings are not blocked by vehicle components (i.e.: open trunks or compartment doors), people, vehicles, or other obstructions. It is the user’s responsibility to understand and obey all laws regarding emergency warning devices. The user should be familiar with all applicable laws and regulations prior to the use of any emergency vehicle warning device. Whelen’s audible warning devices are designed to project sound in a forward direction away from the vehicle occupants. However, because sustained periodic exposure to loud sounds can cause hearing loss, all audible warning devices should be installed and operated in accordance with the standards established by the National Fire Protection Association.Safety FirstThis document provides all the necessary information to allow your Whelen product to be properly and safely installed. Before beginning the installation and/or operation of your new product, the installation technician and operator must read this manual completely. Important information is contained herein that could prevent serious injury or damage.51 Winthrop RoadChester, Connecticut 06412-0684Phone: (860) 526-9504Internet: Sales e-mail: autosale@Customer Service e-mail: custserv@®ENGINEERING COMPANY INC.Page 2Installation: 2010 - 2011 vehicles1.Remove the plastic cover that protects the front area under the hood (Fig. 1).2.Remove the 2 bolts that hold the hood latch assembly on and set it aside (do not disconnect the cables)(Fig. 2).3.Mount the speaker to the bracket (See “Mounting the speaker to the bracket”).4.Mount the bracket behind the hood latch assembly.Be sure to use mounting hardware of sufficient and appropriate length and strength. Slide the bracket (with speaker) into position in the front of the vehicle so the bracket mounting holes line up with the hood latch mounting holes. the vehicle grill is flexible and can be pulled forward to allow the bracket/speaker to fit.5.Be sure all the hood latch cables are properly located,then secure the hood latch assembly over the bracket using the existing hood latch assembly bolts.IMPORTANT: Make sure the two bolt heads line up with the two indentations on the hood latch assembly made by the bolts original position, so that the hood latch assembly reinstalls in the same position and lines up properly with the hood.6.Extend WHITE (positive) and BLACK (negative)speaker wires to your siren amplifier and connect as shown in the amplifiers instructions.7.Replace the vehicles protective cover that you removed in step 1.Installation 2012 Model vehicles:1.Remove the plastic cover that protects the front area under the hood (Fig. 1).2.Following manufactures instructions, remove the front bumper and grill assembly3.Cut out a section of the plastic guard which covers the mounting area in 2012 model vehicles (Fig. 3).4.Remove the 2 bolts that hold the hood latch assembly on and set it aside (do not disconnect the cables) (Fig. 2).5.Mount the speaker to the bracket (See “Mounting the speaker to the bracket”).6.Mount the bracket behind the hood latch assembly. Be sureto use mounting hardware of sufficient and appropriate length and strength. Slide the bracket (with speaker) into position in the front of the vehicle so the bracket mounting holes line up with the hood latch mounting holes. the vehicle grill is flexible and can be pulled forward to allow the bracket/speaker to fit.7.Be sure all the hood latch cables are properly located, then secure the hood latch assembly over the bracket using mounting hardware of sufficient and appropriate length and strength . IMPORTANT: Make sure the two bolt heads line up with the two indentations on the hood latch assembly made by the bolts original position, so that the hood latch assembly reinstalls in the same position and lines up properly with the hood.8.Extend WHITE (positive) and BLACK (negative) speaker wires to your siren amplifier and connect as shown in the amplifiers instructions.9.Replace the vehicles protective cover that you removed in step 1 and replace the bumper and grill assembly.。