糖尿病的研究进展

Generation of functional human pancreaticβcells in vitro
Trudeau Remarks :
Generation of functional human pancreaticβcells in vitro
Word list
hPSC：human pluripotent stem cells 人体多能干细胞 SC-β：stem cell derived βcells 由干细胞分化的β细胞 INS+：generating insulin producing 胰岛素阳性
Discussion
The gene expression —— similar to adult human’s. gene expression differences still remain. possibility ：additional modifications,
added factors … —— shift the cells.
Generation of functional human pancreaticβcells in vitro
体外培养——人体功能性胰岛B细胞 治疗糖尿病
The Latest Research progress of Diabetes Therapy Speaker: Wei W, Xiao Z 2016. 03.23
University of Massachusetts Medical School, 368 Plantation Street, AS7-2051, Worcester, MA 01605 Generation of functional human pancreaticβcells in vitro
Catalogue
Background Introduction Method Result Conclusion References
Generation of functional human pancreaticβcells in vitro
Background
［2］Blum B, Hrvatin SS, Schuetz C, Bonal C, Rezania
［3］Kim SK, Hebrok M, Li E, Oh SP , Schrewe H,
Generation of functional human pancreaticβcells in vitro
urination thirst hunger blood glucose
Various complications.
Generation of functional human pancreaticβcells in vitro
methods
Generation of functional human pancreaticβcells in vitro
PH：polyhormonal cells 分泌多激素的细胞
1°βcell：
primary β cell 原始β细胞
Generation of functional human pancreaticβcells in vitro
References
［1］Apelqvist A, Li H, Sommer L, Beatus P , Anderson
Fra Baidu bibliotek
Generation of functional human pancreaticβcells in vitro
Generation of functional human pancreaticβcells in vitro
Results
Generation of functional human pancreaticβcells in vitro
Source
Published in Cell.
final edited form as: Cell.2015 October 9.
Author：Felicia W. Pagliuca1, Jeffrey R.
Millman1, Quinn P . Peterson1, Dale Greiner2,
JAMA notes《美国医学会杂志》:
A breakthrough —— treatment of diabetes. 15 patients —— with type 1 diabetes stem cell transplantation experiments , in Brazil. 13 patients ——got rid of insulin dependence and did not need to take other drugs. The first patient undergoing experimental——not artificial insulin injection for three years. stem cell therapy.
Generation of functional human pancreaticβcells in vitro
Introduction
Type 1 diabetes. Causes are unknown. Results—— insulin Symptom——weight
Thanks for your Attention!
Generation of functional human pancreaticβcells in vitro
DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H. Nature. 2009; 400:877–881. [PubMed: 10476967] A, Melton DA. Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat Biotechnol. 2012 Feb 26; 30(3):261–4. 2012. [PubMed: 22371083] Harmon EB, Lee JS, Melton DA. Activin receptor patterning of foregut organogenesis. Genes Dev. 2000; 14:1866–1871. [PubMed: 10921901]
1 Department of Stem Cell and
Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138
2 Diabetes Center of Excellence,