妊娠期女性甲状腺功能减退对母婴结局的作用分析

妊娠期女性甲状腺功能减退对母婴结局的作用分析
赵士英
【期刊名称】《中国医药科学》
【年(卷),期】2016(6)20
【摘要】ObjectiveTo analyze the correlation between maternal hypothyroidism and the outcome of maternal and infant pregnancy. Methods 789 cases of pregnant women taking pregnancy test in our hospital and with complete follow-up data were selected as the study objects. Thyroid functions were detected in all 12-38 weeks of pregnant women.The pregnant women with normal thyroid index were divided into normal thyroid group, and pregnant women with hyperthyroidism or hypothyroidism were divided into abnormal thyroid group. And the final maternal pregnancy outcome was finally investigated. ResultsThere was no significant difference in the values of TSH,FT3 and FT4 between the second trimester and the third trimester of pregnancy in the same
group(P>0.05).By observing the relationship between the different periods of pregnancy urinary iodine and thyroid function grading, the result showed that Proportion of patients with Urinary iodine<150μg/L of normal thyroid group was significantly higher than abnormal thyroid group, and the difference had statistical significace(P<0.05).Different levels of neonatal thyroid hormone iodine rating had significant difference in normal thyroid group(P<0.05).The incidence rate of neonatal thyroid hormone
level<150μg/L corresponding to Iodine rating<150μg/L was significantly higher than that of neonatal thyroid hormone level between 150-300μg/L or>300μg/L,and the difference had statistical significance
(P<0.05).Conclusion Hypothyroidism during pregnancy may has possible negative effects on pregnancy outcome and neonatal thyroid function.So it is nessesary to strengthen the urinary iodine examination in early pregnancy test in obstetrics and Gynecology doctor to prevent adverse pregnancy outcome.%目的：分析妊娠母体甲状腺功能减退与母婴妊娠结局的相关性。

方法选取2014年1月～2016年1月在我院进行孕检，且随访资料完整的孕妇789例作为研究对象，对所有产妇12～38周的甲状腺功能进行检测，将甲
状腺正常指标产妇作为正常组，甲亢或甲减作为甲状腺异常组，并最终调查产妇的妊娠结局情况。

结果本组孕妇孕中期与孕晚期TSH、FT3、FT4的值相比差异无统计学意义（P＞0.05）；观察不同妊娠时期尿碘分级与甲状腺功能的关系，结果发现甲状腺正常组的尿碘＜150μg/L患者所占比例要显著高于异常组，差异有统计
学价值（P＜0.05）；甲状腺激素正常组不同尿碘分级的新生儿甲状腺激素水平比较差异有统计学价值（P＜0.05），其中尿碘分级＜150μg/L 对应的新生儿甲状腺激素水平＜150μg/L的发生率明显高于150～300μg/L及＞300μg/L，差异有统
计学意义（P＜0.05）。

结论孕期的甲状腺功能减退，可能对妊娠结局以及新生儿甲状腺功能带来消极的影响，因此妇产科医生应该在早期孕检时加强对尿碘的检查，预防不良妊娠结局的发生。

【总页数】4页(P79-82)
【作者】赵士英
【作者单位】山东省齐河县妇幼保健院妇产科，山东齐河 251100
【正文语种】中文
【中图分类】R714.256
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