MARKER FOR THE DIAGNOSIS OF CANCER
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专利名称：MARKER FOR THE DIAGNOSIS OF CANCER 发明人：ZIEKER, DEREK
申请号：EP08838200.7
申请日：20081001
公开号：EP2198058B1
公开日：
20150805
专利内容由知识产权出版社提供
摘要：The invention relates to the use of phosphoglycerate-kinase 1 (PGK1), or fragments thereof, as a diagnostic marker m for the prognosis or diagnosis of peritoneal carcinamatoses and/or metastasizing primary tumours. The invention also relates to the use of an active substance that inhibits the activity and/or expression of phosphoglycerate-kinase 1 (PGK1), combined with an active substance that inhibits the activity and/or expression of beta-catenin, CXCR4 and/or CXCL12, for producing a medicament for the treatment and/or prevention of peritoneal carcinamatoses and/or metastasizing primary tumours. The invention further relates to pharmaceutical compositions comprising an active substance that inhibits the activity and/or expression of phosphoglycerate-kinase 1 (PGK1), and optionally, at least one pharmaceutically acceptable carrier, and pharmaceutical compositions comprising an active substance that inhibits the activity and/or the expression of phosphoglycerate-kinase 1 (PGK1), and at least one active substance that inhibits the activity and/or expression of beta-catenin, CXCR4 and/or CXCL12, and optionally, at least one pharmaceutically acceptable carrier.
申请人：EBERHARD-KARLS-UNIVERSITÄT TÜBINGEN,EBERHARD KARLS UNIVERSITÄT TÜBINGEN,Eberhard-Karls-Universität Tübingen
地址：DE
国籍：DE
代理机构：Witte, Weller & Partner Patentanwälte mbB 更多信息请下载全文后查看。