大株红景天联合脑苷肌肽治疗糖尿病神经病变的疗效观察
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当代医学 2020 年 3 月第 26 卷第 9 期总第 560 期 Contemporary Medicine，Mar.2020，Vol.26 No.9 Issue No.560
doi：10.3969/j.issn.1009-4393.2020.09.009
--论著--
大株红景天联合脑苷肌肽治疗糖尿病神经病变的 疗效观察
关键词：大株红景天 ；脑苷肌肽 ；DPN
Clinical observation on the effect of Rhodiola kirilowii regel combined with cattle encephalon glycoside and
lgnotin on diabetic peripheral neuropathy
Abstract: Objective To assess the clinical effect of the combined Rhodiola kirilowii regel with cattle encephalon glycoside and lgnotin on dia‐ betic peripheral neuropathy (DPN). Methods 90 patients with diabetic peripheral neuropathy admitted to the fifth people' s hospital of datong city from January 2015 to December 2016 were selected, Rhodiola kirilowii regel group, cattle encephalon glycoside and lgnotin group and combined group, with 30 cases in each group. Median nerve, common peroneus nerve, motor nerve conduction velocity (MCV) and sensory nerves conduction velocity (SCV) were detected, and median nerve, common peroneus nerve, motor nerve amplitude (MAMP) and sen‐ sory nerves amplitude (SAMP) were recorded. Visual Analogue Score（VAS）was analyzed and compared in the three groups. Results The effective rate of the combination group was higher than the other two groups (P＜0.05) , MCV and SCV of the three groups were improved after treatment (P＜ 0.05). After treatment, the SCV and MCV of median nerve in three groups were statistically significant (F=3.458, 3.527, P=0.046, 0.044). After treat‐ ment, the SCV of common peroneal nerve in three groups were statistically significant (F=3.757, P=0.036), and the MCV of common peroneal nerve in three groups were not statistically significant (F=3.259, P=0.054). After treatment, there was no significant difference in the comparison of the three groups of the median nerve (F=3.336, P=0.062), while there was significant difference in the comparison of the three groups of the median nerve (F=3.931, P=0.041). After treatment, there was significant difference in the comparison of the three groups of the common peroneal nerve (F= 3.811, 4.685, P=0.044, 0.025). After treatment, the VAS scores of the three groups were decreased (F=3.607, P＜0.05). Conclusion It was effective to use Chinese medicine Rhodiola kirilowii regel combined with cattle encephalon glycoside and lgnotin in treating DPN.
王慧卿 1，王桂英 1，王迎宾 1，张晋华 1，郭平 1，尉杰忠 1，2
（1. 山西大同大学附属第一医院，山西 大同 037009；2. 山西大同大学脑科学研究所，山西 大同 037006）
摘要：目的 探讨大株红景天联合脑苷肌肽治疗糖尿病周围神经病变（DPN）的临床疗效。方法 选取大同市第五人民医院 2015 年 1 月 至 2016 年 12 月收治的 90 例糖尿病周围神经病变患者，随机分为大株红景天组、脑苷肌肽组、大株红景天与脑苷肌肽联合组，各 30 例。疗程结 束后，评价 3 组治疗总有效率；观察治疗前后正中神经、腓总神经运动神经传导速度（MCV）、感觉神经传导速度（SCV）以及正中神经、腓总神经 运动神经波幅（MAMP）、感觉神经波幅（SAMP）的变化；3 组行视觉模拟评分（VAS）进行疼痛分析比较。结果 治疗后，联合组总有效率明显高于 其他两组（P＜0.05）；治疗后，3 组正中神经 SCV、MCV 比较差异具有统计学意义（F=3.458、3.527，P=0.046、0.044）；治疗后，3 组腓总神经 SCV 比 较差异具有统计学意义（F=3.757，P=0.036），3 组腓总神经 MCV 比较差异无统计学意义（F=3.259，P=0.054）；治疗后，3 组正中神经 SAMP 比较差 异无统计学意义（F=3.336，P=0.062），3 组正中神经 MAMP 比较差异具有统计学意义（F=3.931，P=0.041）；治疗后，3 组腓总神经 SAMP、MAMP 比较 差异具有统计学意义（F=3.811、4.685，P=0.044、0.025）；治疗后，3 组 VAS 评分均下降（F=3.607，P＜0.05）。结论 大株红景天联合脑苷肌肽 治疗糖尿病周围神经病变效果 ，值得推广。
Wang Huiqing1, Wang Guiying1, Wang Yingbin1, Zhang Jinhua1, Guo Ping1, Yu Jiezhong1,2
(1. The First Affiliated Hospital of Shanxi Datong University, Datong, Shanxi, 037009, China; 2. Department of Endocrinology, the Fifth People' s Hospital, Datong, Shanxi, 037006, China)
doi：10.3969/j.issn.1009-4393.2020.09.009
--论著--
大株红景天联合脑苷肌肽治疗糖尿病神经病变的 疗效观察
关键词：大株红景天 ；脑苷肌肽 ；DPN
Clinical observation on the effect of Rhodiola kirilowii regel combined with cattle encephalon glycoside and
lgnotin on diabetic peripheral neuropathy
Abstract: Objective To assess the clinical effect of the combined Rhodiola kirilowii regel with cattle encephalon glycoside and lgnotin on dia‐ betic peripheral neuropathy (DPN). Methods 90 patients with diabetic peripheral neuropathy admitted to the fifth people' s hospital of datong city from January 2015 to December 2016 were selected, Rhodiola kirilowii regel group, cattle encephalon glycoside and lgnotin group and combined group, with 30 cases in each group. Median nerve, common peroneus nerve, motor nerve conduction velocity (MCV) and sensory nerves conduction velocity (SCV) were detected, and median nerve, common peroneus nerve, motor nerve amplitude (MAMP) and sen‐ sory nerves amplitude (SAMP) were recorded. Visual Analogue Score（VAS）was analyzed and compared in the three groups. Results The effective rate of the combination group was higher than the other two groups (P＜0.05) , MCV and SCV of the three groups were improved after treatment (P＜ 0.05). After treatment, the SCV and MCV of median nerve in three groups were statistically significant (F=3.458, 3.527, P=0.046, 0.044). After treat‐ ment, the SCV of common peroneal nerve in three groups were statistically significant (F=3.757, P=0.036), and the MCV of common peroneal nerve in three groups were not statistically significant (F=3.259, P=0.054). After treatment, there was no significant difference in the comparison of the three groups of the median nerve (F=3.336, P=0.062), while there was significant difference in the comparison of the three groups of the median nerve (F=3.931, P=0.041). After treatment, there was significant difference in the comparison of the three groups of the common peroneal nerve (F= 3.811, 4.685, P=0.044, 0.025). After treatment, the VAS scores of the three groups were decreased (F=3.607, P＜0.05). Conclusion It was effective to use Chinese medicine Rhodiola kirilowii regel combined with cattle encephalon glycoside and lgnotin in treating DPN.
王慧卿 1，王桂英 1，王迎宾 1，张晋华 1，郭平 1，尉杰忠 1，2
（1. 山西大同大学附属第一医院，山西 大同 037009；2. 山西大同大学脑科学研究所，山西 大同 037006）
摘要：目的 探讨大株红景天联合脑苷肌肽治疗糖尿病周围神经病变（DPN）的临床疗效。方法 选取大同市第五人民医院 2015 年 1 月 至 2016 年 12 月收治的 90 例糖尿病周围神经病变患者，随机分为大株红景天组、脑苷肌肽组、大株红景天与脑苷肌肽联合组，各 30 例。疗程结 束后，评价 3 组治疗总有效率；观察治疗前后正中神经、腓总神经运动神经传导速度（MCV）、感觉神经传导速度（SCV）以及正中神经、腓总神经 运动神经波幅（MAMP）、感觉神经波幅（SAMP）的变化；3 组行视觉模拟评分（VAS）进行疼痛分析比较。结果 治疗后，联合组总有效率明显高于 其他两组（P＜0.05）；治疗后，3 组正中神经 SCV、MCV 比较差异具有统计学意义（F=3.458、3.527，P=0.046、0.044）；治疗后，3 组腓总神经 SCV 比 较差异具有统计学意义（F=3.757，P=0.036），3 组腓总神经 MCV 比较差异无统计学意义（F=3.259，P=0.054）；治疗后，3 组正中神经 SAMP 比较差 异无统计学意义（F=3.336，P=0.062），3 组正中神经 MAMP 比较差异具有统计学意义（F=3.931，P=0.041）；治疗后，3 组腓总神经 SAMP、MAMP 比较 差异具有统计学意义（F=3.811、4.685，P=0.044、0.025）；治疗后，3 组 VAS 评分均下降（F=3.607，P＜0.05）。结论 大株红景天联合脑苷肌肽 治疗糖尿病周围神经病变效果 ，值得推广。
Wang Huiqing1, Wang Guiying1, Wang Yingbin1, Zhang Jinhua1, Guo Ping1, Yu Jiezhong1,2
(1. The First Affiliated Hospital of Shanxi Datong University, Datong, Shanxi, 037009, China; 2. Department of Endocrinology, the Fifth People' s Hospital, Datong, Shanxi, 037006, China)