碘-125放射性粒子植入治疗对肺癌化疗患者生活质量的影响

实用临床医药杂志Journal of Clinical Medicine in Practice 2022年第24卷第6期

・20・

碘-125放射性粒子植入治疗

对肺癌化疗患者生活质量的影响

张楠

(中国医科大学附属盛京医院放射科，辽宁沈阳，110000)

摘要：目的探讨碘-125(12S I)放射性粒子植入治疗对肺癌患者生活质量的影响。方法选取92例中晚期肺癌患者，随机分为观察组与对照组各46例。对照组采用长春瑞滨联合顺钳方案(NP方案)进行常规化疗，观察组在常规治疗的基础

上进行》I放射性粒子植入治疗。治疗1周后，比较2组临床疗效、不良反应发生情况、生活质量水平以及预后。结果观察组总有效率显著高于对照组(P<0.05)。治疗后，观察组患者的认知功能、社会功能、躯体功能、情绪功能、角色功能等各项生活质量评分均显著高于对照组(P<0.05)。观察组患者不良反应总发生率显著低于对照组(P<0.05)。2组患者1年肿瘤局部控制率和1年生存率比较，差异均无统计学意义(P>0.05)；观察组患者的2年肿瘤局部控制率和2年生存率均显著高于对照组(P<0.05)。结论采用12S I放射性粒子植入手段治疗中晚期肺癌患者，不仅可以有效控制局部肿瘤发展，还能够降低不良反应的发生风险，改善患者的生活质量和预后。

关键词：碘125；放射性粒子；肺癌；植入治疗；生活质量；化疗

中图分类号：R734.2文献标志码：A文章编号：1672-2353(2020)06-022-14D0I：10.0619/jcmp.222206006

Effect of iodine-125radioparticle implantation therapy

on quality of lii in lung cancca pahech with chemotherapy

ZHANG Nan

(Department of'Radiology,Shengjing Hospital Affiliated to China Medical

University，Shepyang，Liaoning，110000)

ABSTRACT:Objective To explore thd effect of ioUiad-223(25I)nCiopiticid implantatiou therapy ou qulity of life i n patiecis with lung caacen.Methods A totai of22patiecis with miOdic

ant aPvaaced lrng caacen were selected ant ranComiy divifed inti oUsenatiou group(n=46)ant cautrot gnup(n=46).The coutrol gnup received小—^止―dpy of viaorelbiae combined witli cispi-atin(NP pine)，whiic thc oUsenatiou group received15I raniouanicic implantatiou ou thc basip of cauvedtiouai treatmect.Aftcn12weedp of ireatmect，thc clinicai efficacy,a nvvrse reactioup，qudlity

of lit ant propeosip were compared bdwcd thc two group,.Results Thc totai effective etc of thc ouseeatiou group wpp sivnificant-y higher1110thp,of thc coutrol group(P<0.03).Aftee treatmedi，

thc score,of counitive1x3000，sociai fpectiou，physical1x3000，emotiouai fpectiou ant roic fpec-tiou in thc oUseoatiou group were signimcant-y highd thae W osc in thc coutrol group(P<0.05).

The totai mcinedca raic of anverse reactioue in thc oUseoatiou group wae sianificant-y lowee thae that

m W c coutrol group(P<0.03).Them were co signiOcact diOeredcee in1-oede I oco-coutrol raic anC

1-oede spmivv-rate setweed the two groupe(P>0.05).The2-yer locai coutrol rate anC2-yer see-vivai ratc in the oUservatiou group were significant-e highcn thac those in the coutrol group(P<

0.05).Conclusion The15I raniouartic-c implantatiou therape foe patiedte with middle anC aP-vacced lpnccac cot oniy effectiveie coutrol the dlvbpmedt of locai Wmoie,sut alse redpea

the O s P of aPverse reactioce anC improve the qpality of life anC propcosie of patiedte.

KEY WORDS:mpicc225；raPioactive panicle；lpnc caccen；implantation therape；qpality

of lit；cOemotherape

肺癌是临床上常见的呼吸系统恶性肿瘤，其中非小细胞肺癌(NSCLC)所占比例较大〔2。收稿日期：2019-11-26录用日期：2025-02-19