The Peer Sampling Service Experimental Evaluation of Unstructured Gossip-Based Implementati
坐地铁出去玩的英语作文
坐地铁出去玩的英语作文Title: A Subway Adventure。
Taking the subway for a day out is always an exciting adventure. As I step into the bustling station, the anticipation of exploring a new destination fills me with excitement and wonder. The rhythmic hum of trains arriving and departing, the chatter of fellow travelers, and the scent of freshly brewed coffee from nearby cafes create an atmosphere ripe with possibility.First and foremost, the subway system serves as the lifeline of urban travel, seamlessly connecting diverse neighborhoods and communities. It's a marvel of engineering and efficiency, whisking passengers from one corner of the city to another in a matter of minutes. As I descend into the underground labyrinth, I can't help but marvel at the intricate network of tunnels and tracks that crisscross beneath the city streets.One of the joys of subway travel is the opportunity to people-watch. Each station is a microcosm of the city itself, teeming with individuals from all walks of life. From weary commuters lost in thought to exuberant tourists eagerly clutching maps, the subway is a melting pot of human experiences. It's a reminder of the rich tapestry of humanity that makes up the fabric of urban life.As the train rattles and lurches along its course, I peer out the window, taking in the sights and sounds of the city above. From towering skyscrapers to quaint neighborhood shops, the passing scenery offers a glimpse into the soul of the city. Each stop along the way presents new opportunities for exploration, whether it's sampling local cuisine, browsing eclectic boutiques, or simply soaking in the ambiance of a bustling street corner.Of course, no subway adventure would be complete without a bit of spontaneity. Sometimes, the best discoveries are made when we stray from the beaten path and embrace the unknown. Whether it's stumbling upon a hidden gem of a cafe tucked away in a quiet alley or striking up aconversation with a friendly local on the train, these serendipitous moments add an element of surprise anddelight to the journey.As the day draws to a close and I make my way back home, I can't help but reflect on the myriad experiences and encounters that have enriched my subway adventure. From the thrill of navigating unfamiliar streets to the warmth of connecting with fellow travelers, each moment has left an indelible impression on my heart. Indeed, the subway isn't just a mode of transportation—it's a gateway to new experiences, new perspectives, and new friendships.In conclusion, a day out on the subway is more thanjust a means of getting from point A to point B. It's an immersive journey through the heart and soul of the city, a tapestry of sights, sounds, and sensations that ignite the imagination and awaken the spirit of adventure within us.So the next time you find yourself with a free day and a sense of wanderlust, why not hop on the subway and seewhere the tracks take you? You never know what surprises await just around the bend.。
关于PLC的中英文对照翻译
原文:PLC Communication using PROFINET: ExperimentalResults and AnalysisAbstractPROFINET is the Industrial Ethernet Standard devised by PROFIBUS International for “Ethernet on the plant floor”. PROFINET allows to implement a comprehensive communications solution on Ethernet which includes peer-to-peer communication between controllers, distributed I/O, machine safety, motion control and data acquisition. In this paper an analysis is conducted on the peer-to-peer interlocking performance based on PROFINET specification. Tests were performed to determine the performance of the peer-to-peer communication mechanism, to evaluate the impact of switches on the system, and to measure the impact of data size on peer-to-peer communication performance. The paper summarizes the test results. 1.IntroductionAlthough a wide variety of networks and fieldbuse s have been used in the manufacturing industry over the past decade [1], the widespread adoption of Ethernet as a de facto standard in other domains (e.g., the internet) has made it an attractive option to consider. The increased network speed and the reduced cost of devices has further heightened interest. The introduction of switched Ethernet has allowed formore deterministic behavior and alleviated many of the concerns about unbounded delays [2, 3, 4]. Ethernet is already being widely used as a diagnostic network in manufacturing systems and is making inroads into the control networking domain [5, 6].However, standard Ethernet (IEEE 802.3) is not a deterministic protocol, and network quality of service cannot be guaranteed. To address this inherent nondeterminism, different “flavors” of Ethernet have been proposed for use in industrial automation. Several of these add layers on top of standard Ethernet or on top of the TCP/IP protocol suite to enable the behavior of Ethernet to be moredeterministic [7]. However, the network solutions may no longer be “Ethernet” other than at the physical layer.Since time delay is an important issue in control systems, there have been a number of projects devoted to analyzing and experimentally testing network performance for use in control systems. It has been shown that the largest component of the time delay in sending messages from one node to another is typically not on the network itself, but rather the application layer that interfaces to the network [8, 9]. Experimental analyses have been carried out to specifically address the issue of delays in switched Ethernet [10, 4]. However, due to the relatively recent introduction of commercial devices that implement the new industrial Ethernet protocols, there have been only a few published accounts of their actual performance [11, 12].Over the past six months, our group at the University of Michigan has undertaken an industrial Ethernet testing project [13]. The goal of the project was to evaluate the suitability of real-time Ethernet for peer-to-peer communication between PLCs on a factory floor. The purpose of this paper is to summarize the results of our tests on PROFINET, and discuss our findings.The outline of the paper is as follows. In Section II, we summarize how PROFINET enables real-time communication over Ethernet. In Section III, we describe the tests that were performed. Section IV presents the results of those tests, and conclusions are given in Section V.2.PROFINET CBA with Real-Time Channel Communication PROFINET distinguishes two views: PROFINET IO for integration of distributed I/O and PROFINET CBA (Component Based Automation) for creation of peer-to-peer communication and interlocking between controllers in modular plants (Figure 1)All other PROFINET applications such as safety, motion control, and HMI (Human Machine Interface) are based on these communication modes. PROFINET communication is scalable in three levels: PROFINET TCP/IP Communication (NRT) enables cycle times as low as 100 ms, PROFINET Real-Time Communication (RT) enables cycle times up to 1-10 ms and Isochronous Real-Time Communication (IRT) enables cycle times up to 1 ms with Jitter less than 1µs.Component based communication is realized through PROFINET CBA which uses selectively the TCP/IP or the Real-Time (RT) channel. Communication for distributed I/O is implemented through PROFINET I/O which uses Real-Time and Isochronous Real-Time (IRT) communication.PROFINET Real-Time Channel The PROFINET Real Time Channel is a cyclic communication path used by individual stations to exchange time critical data at periodic intervals specified by the programmer. It is based on the IEEE and IEC definition s [14], which only permit a limited time for execution of Real-Time services within a bus cycle. Real-Time data are handled with higher priority than Non-Real-Time (NRT) data. The tightness of the window depends on the Real-Time characteristics. The Real-Time mechanism is based on Layer 2 of the OSI model and several protocol layers are omitted. Thus the communication overhead associated with preparing data, transferring it and making it available to the overlying application for use are reduced. Using Ethereal it was found that the total overhead associated with Cyclic Real Time communication is 56 bytes.3.Tests PerformedThe following tests were designed to measure the impact of system parameters on peer-to-peer interlocking performance using PROFINET CBA with RTcommunication method. The system parameters include data size and number of switches. The tests are vendor neutral so that any implementation can be configured to undergo each test. Connection failures or errors are not included in this test plan. To perform tests the following equipment was used: one computer with Matlab and the protocol analyzer Ethereal, SIMATIC iMap and STEP7 as configuration software, five switches from Hirschmann and two Siemens SIMATIC PLCs (Programmable Logic Controllers). The PLCs were configured using the factory defaults for processor and communication allocation options. The Hirschmann switches (100Mbps) were configured for port speed auto negotiation. Due to the fact that PROFINET is based on Unicast communication the Multic ast functionality was not configured in the switches.3.1 PerformanceMetricsThe performance metrics analyzed are PLC1 Packet Time Interval and Round Trip Time Interval.PLC1 Packet Time Interval is the time between two successive transmittals of packets from PLC1. Ideally, the PLC1 Packet Time Interval is always exactly the same as the configured update interval in the PLC. However, in practice there is some variability associated with this interval. The experimental results that follow summarize the average (mean value) and the jitter (standard deviation) of the PLC1 packet time interval. These metrics (mean and standard deviation) are important, as they give ameasure of the determinismthat can be obtained for realtime control using PROFINET.Round Trip Time Interval is defined as the Time Interval needed for a packet from PLC1 to reach PLC2, be echoed and come back to PLC1. Consider a test where PLC1 generates data and PLC2 echoes themback to PLC1 through a switch.Figure 2 shows the timing chart for the communication between PLC1 and PLC2 where PLC1 sends messages at T1, T2, T3,. . . and PLC2 echoes at t1, t2, t3,. . . . PLC1 Packet Time Interval should be equal to the configured update interval on PLC1, and PLC2 Packet Time Interval should be equal to configured update interval on PLC2. If the echo from PLC2 arrives before T2, then the round trip counter getsincremented and the new value is transmitted from PLC1 at T2. Since the increment of the round trip counter is taken for calculation of the Round Trip Time Interval, in this case it should be equal to the PLC1 Packet Time Interval. Consider the case when t1 shifts relative to T2. Then the echo fromPLC2 is received after T2, and the round trip counter is not incremented in themessage transmitted from PLC1 at T2. Hence, the Round Trip Time Interval becomes twice the PLC1 Packet Time Interval.Figure 2. Timing chartFrom the above observations it is noticed that Round Trip Time interval mean and standard deviation are also important as measures of the degree of synchronization for real-time control using PROFINET.3.2 Test DescriptionsTest1: Benchmark Test1 is the benchmark test. The other tests are compared to Test1. In this test PLC1 generates eight bytes of data and PLC2 echoes it back to PLC1 through a switch. PLC1 uses the last 4 bytes (dint) of the data for a new data received counter. PLC1 increments this counter as discussed in section 3.1.To perform measurements, a PC running Ethereal was connected to the managed switch which connects to the PLCs. All packets going to and from PLC2 and theirrespective timestamps were mirrored onto this port.Test2: Network Switches The objective of Test2 is to evaluate the impact that switches introduce to the system. The number of switches between two PLCs is the test variable. The same variables are measured as in Test1. We will consider the case of three and five switches between the PLCs.Test3: Size of Data The objective of Test3 is to measure the impact of data size on peer-to-peer communication performance. The test variable is the data size. Measurements are performed as described in Test1. We will consider two cases. In the first case 216 bytes of unused data, in the second 440 bytes of unused data.4.Test ResultsIn performing the tests and analyzing the results a data capture of 5000 packets per PLC is considered in order to assess the timing performance. The average and standard deviation values of PLC1 Packet Time Interval and Round Trip Time Interval are measured in milliseconds and rounded off to th ree significant digits after the decimal point. All tests are performed with an update time of 8ms which is typical for these applications in the factory. Figures 3, 4 and 5 show the benchmark test results, PLC1 Packet Time Interval, Round Trip Time Interval histogram, and Round Trip Time Interval scattering diagram respectively. We can notice the highly deterministic behavior of the network. Since we are using the PROFINET RT protocol a similar behavior is expected also from the other tests.Figure 3. Test1 PLC1 Packet Time Interval histogram4.1 Network SwitchesTo evaluate the impact that switches introduce to the system, data results from Test1 will be compared to those obtained from Test2. Tables 1 and 2 show that, in the case of three or five switche s between two PLCs, there are no significant changes between the two tests. PLCs Packet Time Interval and Round Trip Time Interval present the same average value and similar standard deviation. Figure 6 shows the histogram of round trip time interval for Test2 which is close to that of Test1 (Figure 4). As expected the switches do not alter the performance metrics. Similar resultswere found in [10].Figure 4. Test1 Round Trip Time Interval histogramFigure 5. Test1 Round Trip Time Interval scattering diagramFigure 6. Test2 Round Trip Time Interval histogram, case with 3 switches4.2 Size of DataBy comparing the results of Test1 and Test3 we will measure the impact of data size on peer-to-peer communication performance. As observed in Tables 1 and 2, PLC1 packet and Round Trip Time Interval average values are the same. In both PLC1 packet and Round Trip Time Intervals there is a decrease of value in standard deviation. Figure 7 shows the Round Trip Time Interval of Test3 with three switches which behaves like Test1 round trip interval (Figure 4). From the results obtained (Tables 1 and 2) we can conclude that data size does not impact Packet and RoundTrip Time Interval.Figure 7. Test3 Round Trip Time Interval histogram, case with 216 bytes 5.ConclusionsTo measure the impact of data size carried by a packet and switches on a PROFINET CBA with RT communication based network three tests were designed. Test1, represented by a simple network made of two PLCs and one switch, was used as benchmark. Figures 3, 4 and 5 showed the deterministic behavior of the network. Test2 is similar to Test1 but instead of one switch, three to five have been used. Test3 is also similar to Test1 but, instead of using 8 bytes data per packet, 216 and 440 bytes were used. To investigate the delay introduced by the switches Test1 and Test2 results were compared. The impact of data size was analyzed by comparing Test1 and Test3. Results show that PLC1 Packet Time Interval and Round Trip Time Interval are unaffected by data size per packet and number of switches. AcknowledgementsThis work was supported in part by the Engineering Research Center for Reconfigurable Manufacturing Systems of the National Science Foundation under Award Number EEC-9529125. The authors would also like to acknowledge the support received from General Motors Powertrain, Siemens and Hirschmann in thecompletion of the tests.References[1] J.-P. Thomesse, “Fieldbus Technology in Industrial Automation”, Proc. of theIEEE, vol. 93, no. 6, 2005.[2] J. M oyne and F. Lian, “Design considerations for a sensor bus system insemiconductor manufacturing”, in International SEMATECH AEC/APC Workshop XII, 2000.[3] P. G. Otanez, J. T. Parrott, J. R.Moyne, and D. M. Tilbury, “The Implications ofEthernet as a Co ntrol Network”, in Proc. of the Global Powertrain Congress, 2002.[4] K. C. Lee and S. Lee, “Performance evaluation of switched Ethernet fornetworked control systems”, in Proc. of IEEE Conf. of the Industrial Electronics Society, volume 4, 2002.[5] J.-D. Decotignie, “Ethernet-Based Real-Time and Industrial Communications”,Proc. of the IEEE, vol. 93, no. 6, 2005.[6] J. Montague, “Networks Busting Out All Over”, Control Engineering, vol. 52, no.3, March 2005.[7] M. Felser, “Real-Time Ethernet—Indus try Prospective”, Proc. of the IEEE, vol. 93,no. 6, 2005.[8] F.-L. Lian, J. R. Moyne, and D. M. Tilbury, “Network Design Consideration forDistributed Control Systems”, IEEE Trans. on Control Systems Technology, vol.10, no. 2, 2002.[9] J. T. Parrott, J. R. Moyne, and D. M. Tilbury, “Experimental Determination ofNetwork Quality of Service in Ethernet: UDP, OPC, and VPN”, in Proc. of the American Control Conf., 2006.[10] E. V onnahme, S. Ruping, and U. Ruckert, “Measurements in switched Ethernetne tworks used for automation systems”, in Proc. of IEEE International Workshop on Factory Communication Systems, 2000.[11] P. Ferrari, A. Flammini, and S. Vitturi, “Response Times Evaluation ofPROFINETNetworks”, in Proc. of the IEEE Int. Symposium on IndustrialElectronics, 2005.[12] P. Ferrari, A. Flammini, D.Marioli, and A. Taroni, “Experimental evaluation ofPROFINET performance”, in Proc.of the IEEE Int.Workshop on Factory Communication Systems (WFCS), 2004.[13] K. Acton, S. Mantri, J. Parrott, N. Kalappa, M. Antolovic, J. Luntz, J. Moyne,and D. Tilbury, “UM-ERC Industrial Ethernet Evaluation Project: Peer-to-peer Interlockign Performance Report”, Technical report, University of Michigan Engineering Research Center for Reconfigurable Manufactu ring Systems, February 2006.[14] M. Popp, K. Weber, “The Rapid Way to PROFINET”,Editor PROFIBUSNutzeroranisation e.V., 2004.译文:PROFINET在PLC通讯中的使用:实验结果及分析摘要:PROFINET是国际现场总线在“以太网物理层”分离出来的工业以太网标准。
如何进行科学研究与试验发展工作英文作文
如何进行科学研究与试验发展工作英文作文Scientific research and experimental development, commonly known as R&D, play a crucial role in advancing knowledge, fostering innovation, and driving technological progress in various fields. In the contemporary world, R&D activities have become instrumental in addressing complex societal challenges, enhancing industrial competitiveness, and improving quality of life. Thus, it is imperative to understand the fundamental principles and key steps involved in conducting scientific research and experimental development work.The process of conducting scientific research and experimental development work typically begins with identifying a research question or problem. This initial stage involves conducting a comprehensive review of existing literature, theories, and empirical evidence to gain insightsinto the current state of knowledge and identify gaps in understanding. Subsequently, researchers need to formulate clear research objectives, hypotheses, or research questions that will guide their investigative efforts.Once the research problem has been clearly defined, researchers must design a robust research methodology that aligns with the nature of the research problem and the desired outcomes. This may involve selecting appropriate research methods, such as quantitative or qualitative approaches, experimental design, data collection techniques, and sampling strategies. Ethical considerations, data validity, reliability, and generalizability are critical factors to be taken into account during this stage.With the research design in place, researchers can proceed to data collection and experimentation. Careful attention must be given to ensuring the quality and integrity of data, minimizing biases, and controlling extraneousvariables. Depending on the nature of the research, this stage may involve conducting laboratory experiments, field studies, surveys, interviews, or observational research. Rigorous data analysis and interpretation are essential to derive meaningful insights and draw valid conclusions from the collected data.The outcomes of scientific research and experimental development work are typically disseminated through various scholarly channels, such as peer-reviewed journals, academic conferences, research symposiums, and institutional reports. Publishing research findings contributes to the body of knowledge within a particular discipline, enables the exchange of ideas and insights, and facilitates ongoing discourse and debate among researchers.Moreover, successful R&D outcomes often lead to the development of innovative products, processes, technologies, or services that have practical applications in industry,healthcare, agriculture, environmental sustainability, and other domains. Translating research outcomes into tangible outcomes requires collaboration with industry partners, technology transfer, patenting, and commercialization strategies.It is also important to acknowledge that scientific research and experimental development work often involve interdisciplinary collaboration, involving experts from diverse fields, including natural sciences, social sciences, engineering, medicine, and humanities. Cross-disciplinary exchanges of knowledge and expertise can enrich the research process and lead to novel insights and breakthrough discoveries.In conclusion, conducting scientific research and experimental development work is a multifaceted and dynamic endeavor that demands meticulous planning, methodological rigor, ethical responsibility, and collaborative engagement.By embracing these principles and practices, researchers can make valuable contributions to advancing knowledge, solving complex problems, and fostering innovation for the betterment of society and the world at large.。
scientific reports peer-review -回复
scientific reports peer-review -回复[scientific reports peer review]Title: The Importance and Process of Peer Review in Scientific ReportsIntroduction:In the realm of scientific research, the publication of scientific reports plays a crucial role in disseminating new knowledge and advancing our understanding of various phenomena. However, to ensure the accuracy and reliability of these reports, it is essential to subject them to a rigorous process of peer review. This article aims to shed light on the importance of peer review and provide a comprehensive overview of its step-by-step process.1. Importance of peer review in scientific reports (300 - 350 words): The peer review process serves as the cornerstone of scientific publishing and is designed to evaluate the quality and validity of research before it is published. It offers several key benefits, including:a. Ensuring scientific rigor: Peer review helps ensure that published reports meet high scientific standards, promoting reliability andintegrity in research findings.b. Identifying errors and bias: The scrutiny of multiple expert reviewers helps identify any erroneous claims or biases present in the research, improving the quality of the report.c. Enhancing credibility: Peer-reviewed reports are widely considered to be more credible by the scientific community, allowing for greater acceptance and wider dissemination of findings.d. Facilitating scientific discourse: Peer review encourages constructive criticism and feedback, enabling researchers to refine their work and contribute to scientific discussions.2. Step-by-step process of peer review (1100 - 1300 words):a. Submission and initial evaluation:i. Authors submit their research manuscript to a scientific journal, following the guidelines and instructions provided by the journal.ii. The journal's editor-in-chief reviews the manuscript, assessing its relevance, scientific novelty, general quality, and adherence to journal guidelines.iii. If the manuscript meets initial criteria, it proceeds to the next stage; otherwise, it may be rejected or sent back to the authors forrevision.b. Selection of peer reviewers:i. The editor selects a group of experts in the relevant field to review the manuscript. These reviewers should have expertise in the subject matter and preferably hold no conflicts of interest.ii. The reviewers are invited to review the manuscript while maintaining confidentiality about the process.c. Peer review and evaluation:i. The reviewers analyze the manuscript thoroughly, evaluating its methodology, experimental design, statistical analysis, and conclusion.ii. They assess the significance, originality, and validity of the findings and identify any areas that need improvement.iii. Reviewers provide feedback to the editor, pointing out strengths, weaknesses, and potential revisions. They may recommend accepting the manuscript, accepting it with revisions, or rejecting it based on inadequacies.d. Revision and resubmission:i. If the paper requires revisions, the editor conveys thereviewer's comments and recommendations to the authors.ii. Authors revise the manuscript, addressing the reviewer's concerns, and providing explanations or additional data when necessary.iii. The revised manuscript is submitted back to the editor, who assesses whether the revisions adequately address the reviewer's concerns.e. Final decision and publication:i. The editor evaluates the revisions and feedback provided by the reviewer, making the final decision.ii. Possible decisions include accepting the revised manuscript, requesting further revisions, or rejecting the manuscript.iii. Once accepted, the manuscript undergoes copyediting, formatting, and publication in the scientific journal.Conclusion:Peer review is an indispensable process in ensuring the quality and reliability of scientific reports. It plays a pivotal role in maintaining scientific rigor, identifying errors and bias, enhancing credibility, and facilitating scientific discourse. By understanding thestep-by-step process of peer review, both researchers and readers can appreciate the significance and value it brings to scientific publications.。
Sociology专业英语单词
Sociology专业英语AActionAdaptationAgencyAlienationAnomieAuthoritarianismAgeismAssessmentAnimismAccounting practices Affectivity affective neutrality Achieved statusActing crowdActual social identity Affectual actionAge normsAge structureAnticipatory socialization Ascription—achievement Autopoietic system Authority bureaucratic Authority charismatic Authority dual行动适应能动力异化失范权威主义歧视评估泛灵论项目过程的实践情感中立自治地位行动群体社会认同情感性活动年龄规范年龄结构预期社会化先赋成就自我再生系统个体权威魅力感召性权威双重性权威BBehaviorismBiculturalismBureaucracyBureaucratizationBourgeoisieBreaching experimentsBecause motivesBehavioral illnessBehavioral oganismBehavioral roleBilateral descentBehavioral geneticsBorn criminalsBaby boom行为主义双重文化主义官僚体系科层制资产阶级破坏性实验原因动机行为缺陷行为有机体行为角色双边继嗣行为遗传与生俱来的罪犯婴儿潮CCapitalist Capitalism Census CharismaCode Communism Consummation Conflict perspective Conformity Correlation CrowdCult Counterculture Case studyCaste system资本家资本主义人口普查魅力符号共产主义完成冲突论视角遵从相关集群宗派反文化个案研究种性制Class divisionsClinical—activist modelCommunity controlComparative analysisConspicuous consumptionCrude birth rateCrude death rateCultural diffusionCultural integrationCultural lagCultural pluralismConversation of gestureConstuctivist perspectiveCollective conscienceCultural capitalCulture of poverty阶级分化临床行为者模式社区控制比较分析炫耀性消费粗出生率粗死亡率文化传播文化整合文化堕距文化多元论姿势对话建构观点集体意识文化资本贫穷文化Civic privatismD Deinstitutionalization Democracy Demography Denomination Depersonalization DelianceDeviant DiscriminationDogmaDualismDyadDysfunction Discourses Developmental questions Dual—earner families Dramaturgical perspective Disaster behavior Deviant subculture Disciplinary society Derian career Descriptive studies Dependent variable Dependency theory Dependent chains Democratic socialism Demographic transition Definition of the situation公民个人主义去机制化民主政体人口统计学宗派去个人化越轨行为越轨歧视教义教条二元论对偶组二人群体反功能话语演讲依赖比率拟剧论双职工家庭灾后行为越轨亚文化训规社会越轨生涯描述性研究因变量依赖理论依赖链民主社会主义人口转型情境定义EEcologyEcosystemEmigrationEndogamyEthnocentrismEthnomethodologyExogainyExploitationExpulsionEcological segregationEconomic 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selfMMeMegalopolis 弹性生产制度帮派男同性恋公社性别灭绝老年学治理性一般他人代沟本源结构主义群体意识同类婚假设滞后同性恋恐婚症医疗保健系统霍桑效应阶层式监视人体免疫缺陷病毒水平/横向流动水平分化潜在功能院外活动标签理论劳动价值理论潜功能/隐功能隐形利益法理性权威合法权益功能分析层次预期寿命生命跨度镜中自我客我大都会带IIdeologyIncestImpulseIndustrializationIngroupsInstinctsIntegrationInternalizationInvasionIdeal typeIllegitimate powerImpression managementIncest tabooIndependent variableIn—order—to motiveIndividual cultureInfant mortality rateInformal structureInstitutional racismInteractionist perspectiveInterest groupJJuvenileJuvenile delinquencyJob enlargementKKinshipNNativeNegotiationNetworksNonfunctionsNormalizationNeonatal mortality rateNonmaterial culture意识形态乱伦冲动工业化内群体本能整合内化侵入理想类型非法动机印象管理乱伦禁忌自变量企图的动机个人文化婴儿死亡率非正式结构制度化种族主义理解/理解社会学利益群体青少年青少年犯罪扩展工作亲属关系本国的协商谈判网络非功能正常化标准化新生婴儿死亡率非物质遗产Migration移民核心家庭Nonverbal communicate非语言沟通Nuclear familyMethodologyMobMonogamyMoralize ModernizationMale dominance Manifest function Manifest interests Market socialism Marriage gradientMass behaviorMass ultureMaterical social facts Matriarchal family Matrilineal descent Matrilocal residence Mechanical solidarity Means-ends rational action Migration rateMinority groupMixed economy Multicariate analysisOObjective culture OligarchyOutgroup Overurbanization Opportunity costs Organic solidarityQQualitative methodsQ uantitative methodsRRacism Rationalization ReflxicityReliabilityReligiosity ResocializationRole expectationRiot方法论暴民一夫一妻制道德论现代化男性装扮显功能显现利益市场社会主义婚姻倾度大众行为物质文化物质性社会事实母家庭母亲祭祀从妻居机械团结目标手段理性行为年移民率少数名族群体混合经济多变量分析客观文化寡头政治外群体过度城市化机会成本有机团结定性方法定量方法种族主义理性化反身性信度宗教虔诚再社会化角色期待骚乱PParticipant observationPartitionPatriarchyPersonalityPoliticsPolyandryPolygynyPost-fordismPredictabilityPrejudicePrestigeProfaneProletariatPatriarchal familyPatrilineal descentPatrilocal residencePattern maintenancePeer groupPersonality systemPlanned economyPlay stagePolitical partyPopulation projectionsPoverty levelPostindustrial sociologyPostindustrial societyPrimary groupPrimary socializationPublic opinionPopulation forecastRumorRandom samplingRational-legalReference groupResource mobilizationRevolutionary movementRove conflictRole setRole performanceRole taking参与观察政治区化父权体系人格政体一夫一妻制一夫多妻制后福特主义可预测性偏见声望世俗无产阶级父权家庭父系祭祀从夫居模式维持/维护同辈群体人格体系计划经济扮演期政党人口投影法贫困线后现代社会学后工业社会初级群体初级社会化公众舆论人口预测谣言随机抽样法理性权威参照群体资源动员革命运动角色冲突角色集角色扮演角色置换R itualSSuccessionSelf-segregation StereotypeStandpoint Secularization Superstructure SegregationSelfSparatismSexismStigmaSectSubcultureSactionSelf-control theory Sex ratioSocial devianceSocial disorganization Social interactionSocial control theory Social mobilitySocial movementSocial networkSocial stratification Social structure Sociocultural evolution Socioeconomic status Sociological imagination Structural mobility Symbolic interactionism仪式演替自我隔离刻板印象立场世俗化制约上层建筑自我分离主义性别主义/歧视污名教派亚文化自我控制性别比社会越轨社会解组社会互动社会控制理论社会流动社会运动社会网络社会分层社会结构社会文化进化论社会经济地位社会学想象力结构性流动符号互动论TTheismTotalitarianismTotemTotemismTriadTechnocratic thinkingTheories of everyday lifeTraditional actionT raditional authorityUUrbanismUrbanizationUtilitiesUtopianismUrban ecologistVValidityValue-rational actionVariablesVerstehenVertical mobilityVertical stratificationVital statisticsVictimless crimeVoluntary associationWWorld associationWorking class有神话集权主义图腾图腾崇拜三人群体技术专家思维日常生活理论传统型行为传统型权威城市生活方式城市化效益乌托邦思想城市生态学家效度价值理性行动变量理解垂直流动垂直分层动态流计无受害人犯罪志愿者协会世界体系工人阶级。
练习册题+答案_新编英语教程5_1--10单元
第一单元:1. A word that is more or less right,… clean English.差不多的词,不准确的词语,模棱两可的表达,含糊不清的修饰,都无法使一位追求纯正英语的作家满意。
他会一直思考,直至找到那个能准确表达他意思的词。
2. Choosing words is part of the process … or read our words.选词是认识过程的一个步骤,也是详细描述我们的思想感情并表达出来使自己以及听众和读者深刻理解的一个环节。
3.It is hard work choosing the … finding them brings.寻找恰如其分的词的确是件不容易的事。
一旦找到了那个词,我们就会感到很欣慰:辛劳得到了回报。
4. The exact use of language gives … are dealing with.准确的用语有助于我们深入了解我们描述的事物。
第二单元1.The result is that the Mediterranean, which nurtured so many civilisations, is gravely ill -- the first of the seas to fall victim to the abilities and attitudes that evolved around it.结果导致孕育众多文明的地中海环境极其恶劣—第一个由于其周围人们对其利用能力的增强和对其环境污染的忽视态度而受害的海洋。
2. What is more, most cities just drop it in straight oil the beach; rare indeed are the places like Cannes and Tel Aviv which pipe it even half a mile offshore.更有甚者,多数城市直接将污水倾到海岸上。
Experimental Techniques
Appendix D:Experimental Techniques附录D:实验技术Elucidating the molecular basis of life is no easy task. Our current understanding of complex processes like replication, transcription or translation has required thousands of scientists laboring for decades. Yet, considering the tiny scale on which molecular biologists work, the amount known is admirable. This understanding is due to a powerful set of techniques, tools that allow our immense hands to cut and past molecules, and our blurry eyes to peer inside cells. In this chapter we review the most important of these techniques used today. 要弄清楚生命的分子基础并不是一件容易的事。
我们现在了解的复杂过程,如复制、转录或转译,是几千位科学家通过几十年的辛勤研究得来的。
不过,考虑到分子生物学家工作的对象是如此微小,已获得的知识还是值得称道的。
这样的理解得益于一套有效的技术,这是一些使我们的大手能够去切割并粘贴分子和使我们模糊的眼睛能够窥探细胞内部的工具。
本章我们回顾现今使用的一些最重要的技术。
D.1 DNA ManipulationTechniques D.1 DNA操作技术D.1.1 Gel Electrophoresis andSouthern Blotting D.1.1 凝胶电泳与Southern印迹法Gel electrophoresis is a technique used to separate a mixture of DNA molecules according to length (Figure D.1). DNA molecules are pulled through a gel by a voltage that attracts the negative charges on phosphodiester bonds. The gel is a tangle of polymers that is quite dense, but contains holes through which DNA molecules can pass. Shorter molecules fit more easily through these holes than larger molecules; as a result, the speed at which a DNA molecule moves down the gel is directly related to its size. 凝胶电泳是用来将DNA分子混合物根据它们的长度分开的技术(图D.1)。
chromechromium启动命令行开关参数switchescommandlineflags
chromechromium启动命令⾏开关参数switchescommandlineflagsLast automated update occurred on 2020-08-12.out\Default\chrome1.exe --enable-skia-benchmarking --enable-gpu-benchmarking --no-sandbox --process-per-site --remote-debugging-port=9222 --enable-logging --disable-gpu-rasterization --disable-gpu rem --ui-show-composited-layer-borders --ui-show-layer-animation-bounds --ui-show-paint-rects --ui-show-screenspace-rectsrem http://localhost:8080/a.htmlrem --remote-debugging-port=9222rem --enable-logging --v=1 --disable-gpu-vsync --vmodule=layer_tree_host=3 --ui-show-composited-layer-bordersrem --vmodule=metrics=2,image_animation_controller=2,layer_tree_host_impl=2 --v=0 --trace-startup=ccrem --show-composited-layer-borders --show-screenspace-rects1,常⽤参数软渲染与gpu渲染切换:--disable-gpu-rasterization --disable-gpu启动时指定⽤户数据的存放⽬录--user-data-dir=UserDataDirView Code源码存放:/ / chrome_base/base_switches.h// Copyright (c) 2012 The Chromium Authors. All rights reserved.// Use of this source code is governed by a BSD-style license that can be// found in the LICENSE file.#include "base/base_switches.h"#include "build/build_config.h"namespace switches {// Delays execution of TaskPriority::BEST_EFFORT tasks until shutdown.const char kDisableBestEffortTasks[] = "disable-best-effort-tasks";// Disables the crash reporting.const char kDisableBreakpad[] = "disable-breakpad";// Comma-separated list of feature names to disable. See also kEnableFeatures.const char kDisableFeatures[] = "disable-features";// Force disabling of low-end device mode when set.const char kDisableLowEndDeviceMode[] = "disable-low-end-device-mode";// Indicates that crash reporting should be enabled. On platforms where helper// processes cannot access to files needed to make this decision, this flag is// generated internally.const char kEnableCrashReporter[] = "enable-crash-reporter";// Comma-separated list of feature names to enable. See also kDisableFeatures.const char kEnableFeatures[] = "enable-features";// Force low-end device mode when set.const char kEnableLowEndDeviceMode[] = "enable-low-end-device-mode";// This option can be used to force field trials when testing changes locally.// The argument is a list of name and value pairs, separated by slashes. If a// trial name is prefixed with an asterisk, that trial will start activated.// For example, the following argument defines two trials, with the second one// activated: "GoogleNow/Enable/*MaterialDesignNTP/Default/" This option can// also be used by the browser process to send the list of trials to a// non-browser process, using the same format. See// FieldTrialList::CreateTrialsFromString() in field_trial.h for details.const char kForceFieldTrials[] = "force-fieldtrials";// Generates full memory crash dump.const char kFullMemoryCrashReport[] = "full-memory-crash-report";// Logs information about all tasks posted with TaskPriority::BEST_EFFORT. Use// this to diagnose issues that are thought to be caused by// TaskPriority::BEST_EFFORT execution fences. Note: Tasks posted to a// non-BEST_EFFORT UpdateableSequencedTaskRunner whose priority is later lowered// to BEST_EFFORT are not logged.const char kLogBestEffortTasks[] = "log-best-effort-tasks";// Suppresses all error dialogs when present.const char kNoErrorDialogs[] = "noerrdialogs";// Starts the sampling based profiler for the browser process at startup. This// will only work if chrome has been built with the gn arg enable_profiling =const char kProfilingAtStart[] = "profiling-at-start";// Specifies a location for profiling output. This will only work if chrome has// been built with the gyp variable profiling=1 or gn arg enable_profiling=true.//// {pid} if present will be replaced by the pid of the process.// {count} if present will be incremented each time a profile is generated// for this process.// The default is chrome-profile-{pid} for the browser and test-profile-{pid}// for tests.const char kProfilingFile[] = "profiling-file";// Controls whether profile data is periodically flushed to a file. Normally// the data gets written on exit but cases exist where chromium doesn't exit// cleanly (especially when using single-process). A time in seconds can be// specified.const char kProfilingFlush[] = "profiling-flush";// When running certain tests that spawn child processes, this switch indicates // to the test framework that the current process is a child process.const char kTestChildProcess[] = "test-child-process";// When running certain tests that spawn child processes, this switch indicates // to the test framework that the current process should not initialize ICU to// avoid creating any scoped handles too early in startup.const char kTestDoNotInitializeIcu[] = "test-do-not-initialize-icu";// Sends trace events from these categories to a file.// --trace-to-file on its own sends to default categories.const char kTraceToFile[] = "trace-to-file";// Specifies the file name for --trace-to-file. If unspecified, it will// go to a default file name.const char kTraceToFileName[] = "trace-to-file-name";// Gives the default maximal active V-logging level; 0 is the default.// Normally positive values are used for V-logging levels.const char kV[] = "v";// Gives the per-module maximal V-logging levels to override the value// given by --v. E.g. "my_module=2,foo*=3" would change the logging// level for all code in source files "my_module.*" and "foo*.*"// ("-inl" suffixes are also disregarded for this matching).//// Any pattern containing a forward or backward slash will be tested// against the whole pathname and not just the module. E.g.,// "*/foo/bar/*=2" would change the logging level for all code in// source files under a "foo/bar" directory.const char kVModule[] = "vmodule";// Will wait for 60 seconds for a debugger to come to attach to the process. const char kWaitForDebugger[] = "wait-for-debugger";#if defined(OS_WIN)// Disable high-resolution timer on Windows.const char kDisableHighResTimer[] = "disable-highres-timer";// Disables the USB keyboard detection for blocking the OSK on Win8+.const char kDisableUsbKeyboardDetect[] = "disable-usb-keyboard-detect"; #endif#if defined(OS_LINUX) && !defined(OS_CHROMEOS)// The /dev/shm partition is too small in certain VM environments, causing// Chrome to fail or crash (see /715363). Use this flag to// work-around this issue (a temporary directory will always be used to create// anonymous shared memory files).const char kDisableDevShmUsage[] = "disable-dev-shm-usage";#endif#if defined(OS_POSIX)// Used for turning on Breakpad crash reporting in a debug environment where // crash reporting is typically compiled but disabled.const char kEnableCrashReporterForTesting[] ="enable-crash-reporter-for-testing";#endif#if defined(OS_ANDROID)// Enables the reached code profiler that samples all threads in all processes// to determine which functions are almost never executed.const char kEnableReachedCodeProfiler[] = "enable-reached-code-profiler";#endif#if defined(OS_LINUX)// Controls whether or not retired instruction counts are surfaced for threads// in trace events on Linux.//// This flag requires the BPF sandbox to be disabled.const char kEnableThreadInstructionCount[] = "enable-thread-instruction-count"; #endif} // namespace switchesView Code\content\public\common\content_// Copyright 2012 The Chromium Authors. All rights reserved.// Use of this source code is governed by a BSD-style license that can be// found in the LICENSE file.#include "content/public/common/content_switches.h"#include "build/build_config.h"#include "media/media_buildflags.h"namespace switches {// The number of MSAA samples for canvas2D. Requires MSAA support by GPU to// have an effect. 0 disables MSAA.const char kAcceleratedCanvas2dMSAASampleCount[] = "canvas-msaa-sample-count"; // Allows processing of input before a frame has been committed.// TODO(schenney): Remove when /987626 is fixed.const char kAllowPreCommitInput[] = "allow-pre-commit-input";// By default, file:// URIs cannot read other file:// URIs. This is an// override for developers who need the old behavior for testing.const char kAllowFileAccessFromFiles[] = "allow-file-access-from-files";// Enables TLS/SSL errors on localhost to be ignored (no interstitial,// no blocking of requests).const char kAllowInsecureLocalhost[] = "allow-insecure-localhost";// Allows loopback interface to be added in network list for peer connection.const char kAllowLoopbackInPeerConnection[] ="allow-loopback-in-peer-connection";// Allow a page to show popups during its unloading.// TODO(https:///937569): Remove this in Chrome 82.const char kAllowPopupsDuringPageUnload[] = "allow-popups-during-page-unload";// Allow a page to send synchronus XHR during its unloading.// TODO(https:///1003101): Remove this in Chrome 82.const char kAllowSyncXHRInPageDismissal[] = "allow-sync-xhr-in-page-dimissal";// Uses the android SkFontManager on linux. The specified directory should// include the configuration xml file with the name "fonts.xml".// This is used in blimp to emulate android fonts on linux.const char kAndroidFontsPath[] = "android-fonts-path";// Set blink settings. Format is <name>[=<value],<name>[=<value>],...// The names are declared in Settings.json5. For boolean type, use "true",// "false", or omit '=<value>' part to set to true. For enum type, use the int// value of the enum value. Applied after other command line flags and prefs.const char kBlinkSettings[] = "blink-settings";// Causes the browser process to crash on startup.const char kBrowserCrashTest[] = "crash-test";// Causes the browser process to display a dialog on launch.const char kBrowserStartupDialog[] = "browser-startup-dialog";// Path to the exe to run for the renderer and plugin subprocesses.const char kBrowserSubprocessPath[] = "browser-subprocess-path";// Tells whether the code is running browser tests (this changes the startup URL// used by the content shell and also disables features that can make tests// flaky [like monitoring of memory pressure]).const char kBrowserTest[] = "browser-test";// Sets the tile size used by composited layers.const char kDefaultTileWidth[] = "default-tile-width";const char kDefaultTileHeight[] = "default-tile-height";// Disable antialiasing on 2d canvas.const char kDisable2dCanvasAntialiasing[] = "disable-canvas-aa";// Disables Canvas2D rendering into a scanout buffer for overlay support.const char kDisable2dCanvasImageChromium[] = "disable-2d-canvas-image-chromium"; // Disables client-visible 3D APIs, in particular WebGL and Pepper 3D.// This is controlled by policy and is kept separate from the other// enable/disable switches to avoid accidentally regressing the policy// support for controlling access to these APIs.const char kDisable3DAPIs[] = "disable-3d-apis";// Disable gpu-accelerated 2d canvas.const char kDisableAccelerated2dCanvas[] = "disable-accelerated-2d-canvas";// Disables hardware acceleration of video decode, where available.const char kDisableAcceleratedVideoDecode[] ="disable-accelerated-video-decode";// Disables hardware acceleration of video encode, where available.const char kDisableAcceleratedVideoEncode[] ="disable-accelerated-video-encode";// Disable limits on the number of backing stores. Can prevent blinking for// users with many windows/tabs and lots of memory.const char kDisableBackingStoreLimit[] = "disable-backing-store-limit";// Disable backgrounding renders for occluded windows. Done for tests to avoid// nondeterministic behavior.const char kDisableBackgroundingOccludedWindowsForTesting[] ="disable-backgrounding-occluded-windows";// Disable task throttling of timer tasks from background pages.const char kDisableBackgroundTimerThrottling[] ="disable-background-timer-throttling";// Use names from runtime_enabled_features.json5, separated by commas.// Applied after kEnableBlinkFeatures, and after other flags that change these// features.const char kDisableBlinkFeatures[] = "disable-blink-features";// Enable Web Bluetooth Scanning// This switch enables Web Bluetooth Scanning without any// permission prompt for testing.const char kEnableWebBluetoothScanning[] = "enable-web-bluetooth-scanning"; // Disables HTML5 DB support.const char kDisableDatabases[] = "disable-databases";// Disable the per-domain blocking for 3D APIs after GPU reset.// This switch is intended only for tests.const char kDisableDomainBlockingFor3DAPIs[] ="disable-domain-blocking-for-3d-apis";// Disable all versions of WebGL.const char kDisableWebGL[] = "disable-webgl";// Disable WebGL2.const char kDisableWebGL2[] = "disable-webgl2";// Disable FileSystem API.const char kDisableFileSystem[] = "disable-file-system";// Disable 3D inside of flapper.const char kDisableFlash3d[] = "disable-flash-3d";// Disable Stage3D inside of flapper.const char kDisableFlashStage3d[] = "disable-flash-stage3d";// Disable user gesture requirement for presentation.const char kDisableGestureRequirementForPresentation[] ="disable-gesture-requirement-for-presentation";// Disables GPU hardware acceleration. If software renderer is not in place,// then the GPU process won't launch.const char kDisableGpu[] = "disable-gpu";// Prevent the compositor from using its GPU implementation.const char kDisableGpuCompositing[] = "disable-gpu-compositing";// Disable proactive early init of GPU process.const char kDisableGpuEarlyInit[] = "disable-gpu-early-init";// Do not force that all compositor resources be backed by GPU memory buffers. const char kDisableGpuMemoryBufferCompositorResources[] ="disable-gpu-memory-buffer-compositor-resources";// Disable GpuMemoryBuffer backed VideoFrames.const char kDisableGpuMemoryBufferVideoFrames[] ="disable-gpu-memory-buffer-video-frames";// For tests, to disable the limit on the number of times the GPU process may be // restarted.const char kDisableGpuProcessCrashLimit[] = "disable-gpu-process-crash-limit"; // For tests, to disable falling back to software compositing if the GPU Process // has crashed, and reached the GPU Process crash limit.const char kDisableSoftwareCompositingFallback[] ="disable-software-compositing-fallback";// When using CPU rasterizing disable low resolution tiling. This uses// less power, particularly during animations, but more white may be seen// during fast scrolling especially on slower devices.const char kDisableLowResTiling[] = "disable-low-res-tiling";// Disable the thread that crashes the GPU process if it stops responding to// messages.const char kDisableGpuWatchdog[] = "disable-gpu-watchdog";// Disallow image animations to be reset to the beginning to avoid skipping// many frames. Only effective if compositor image animations are enabled. const char kDisableImageAnimationResync[] = "disable-image-animation-resync"; // Disables the IPC flooding protection.// It is activated by default. Some javascript functions can be used to flood// the browser process with IPC. This protection limits the rate at which they// can be used.const char kDisableIpcFloodingProtection[] = "disable-ipc-flooding-protection";// Suppresses hang monitor dialogs in renderer processes. This may allow slow // unload handlers on a page to prevent the tab from closing, but the Task// Manager can be used to terminate the offending process in this case.const char kDisableHangMonitor[] = "disable-hang-monitor";// Disable the RenderThread's HistogramCustomizer.const char kDisableHistogramCustomizer[] = "disable-histogram-customizer"; // Don't kill a child process when it sends a bad IPC message. Apart// from testing, it is a bad idea from a security perspective to enable// this switch.const char kDisableKillAfterBadIPC[] = "disable-kill-after-bad-ipc";// Disables LCD text.const char kDisableLCDText[] = "disable-lcd-text";// Disable LocalStorage.// Force logging to be disabled. Logging is enabled by default in debug// builds.const char kDisableLogging[] = "disable-logging";// Disables using CODECAPI_AVLowLatencyMode when creating DXVA decoders. const char kDisableLowLatencyDxva[] = "disable-low-latency-dxva";// Disables clearing the rendering output of a renderer when it didn't commit// new output for a while after a top-frame navigation.const char kDisableNewContentRenderingTimeout[] ="disable-new-content-rendering-timeout";// Disables the Web Notification and the Push APIs.const char kDisableNotifications[] = "disable-notifications";// Disable partial raster in the renderer. Disabling this switch also disables// the use of persistent gpu memory buffers.const char kDisablePartialRaster[] = "disable-partial-raster";// Disable Pepper3D.const char kDisablePepper3d[] = "disable-pepper-3d";// Disables the Permissions API.const char kDisablePermissionsAPI[] = "disable-permissions-api";// Disable Image Chromium for Pepper 3d.const char kDisablePepper3DImageChromium[] = "disable-pepper-3d-image-chromium"; // Disables compositor-accelerated touch-screen pinch gestures.const char kDisablePinch[] = "disable-pinch";// Disable the creation of compositing layers when it would prevent LCD text.const char kDisablePreferCompositingToLCDText[] ="disable-prefer-compositing-to-lcd-text";// Disables the Presentation API.const char kDisablePresentationAPI[] = "disable-presentation-api";// Disables throttling of history.pushState/replaceState calls.const char kDisablePushStateThrottle[] = "disable-pushstate-throttle";// Disables RGBA_4444 textures.const char kDisableRGBA4444Textures[] = "disable-rgba-4444-textures";// Taints all <canvas> elements, regardless of origin.const char kDisableReadingFromCanvas[] = "disable-reading-from-canvas";// Disables remote web font support. SVG font should always work whether this// option is specified or not.const char kDisableRemoteFonts[] = "disable-remote-fonts";// Disables the RemotePlayback API.const char kDisableRemotePlaybackAPI[] = "disable-remote-playback-api";// Turns off the accessibility in the renderer.const char kDisableRendererAccessibility[] = "disable-renderer-accessibility";// Prevent renderer process backgrounding when set.const char kDisableRendererBackgrounding[] = "disable-renderer-backgrounding";// Whether the ResourceScheduler is disabled. Note this is only useful for C++// Headless embedders who need to implement their own resource scheduling.const char kDisableResourceScheduler[] = "disable-resource-scheduler";// Disable shared workers.const char kDisableSharedWorkers[] = "disable-shared-workers";// Do not use runtime-detected high-end CPU optimizations in Skia. This is// useful for forcing a baseline code path for e.g. web tests.const char kDisableSkiaRuntimeOpts[] = "disable-skia-runtime-opts";// Disable smooth scrolling for testing.const char kDisableSmoothScrolling[] = "disable-smooth-scrolling";// Disables the use of a 3D software rasterizer.const char kDisableSoftwareRasterizer[] = "disable-software-rasterizer";// Disables the Web Speech API (both speech recognition and synthesis).const char kDisableSpeechAPI[] = "disable-speech-api";// Disables the speech synthesis part of Web Speech API.const char kDisableSpeechSynthesisAPI[] = "disable-speech-synthesis-api";// Disables adding the test certs in the network process.const char kDisableTestCerts[] = "disable-test-root-certs";// Disable multithreaded GPU compositing of web content.const char kDisableThreadedCompositing[] = "disable-threaded-compositing";// Disable multithreaded, compositor scrolling of web content.const char kDisableThreadedScrolling[] = "disable-threaded-scrolling";// Disable V8 idle tasks.const char kDisableV8IdleTasks[] = "disable-v8-idle-tasks";// Disables WebGL rendering into a scanout buffer for overlay support.const char kDisableWebGLImageChromium[] = "disable-webgl-image-chromium";// Don't enforce the same-origin policy. (Used by people testing their sites.)// Disable rasterizer that writes directly to GPU memory associated with tiles. const char kDisableZeroCopy[] = "disable-zero-copy";// Disable the video decoder from drawing directly to a texture.const char kDisableZeroCopyDxgiVideo[] = "disable-zero-copy-dxgi-video";// Specifies if the |DOMAutomationController| needs to be bound in the// renderer. This binding happens on per-frame basis and hence can potentially// be a performance bottleneck. One should only enable it when automating dom// based tests.const char kDomAutomationController[] = "dom-automation";// Disable antialiasing on 2d canvas clipsconst char kDisable2dCanvasClipAntialiasing[] = "disable-2d-canvas-clip-aa";// Disable YUV image decoding for those formats and cases where it's supported. // Has no effect unless GPU rasterization is enabled.const char kDisableYUVImageDecoding[] = "disable-yuv-image-decoding";// Logs Runtime Call Stats for Blink. --single-process also needs to be// used along with this for the stats to be logged.const char kDumpBlinkRuntimeCallStats[] = "dump-blink-runtime-call-stats";// Enables LCD text.const char kEnableLCDText[] = "enable-lcd-text";// Enable the creation of compositing layers when it would prevent LCD text.const char kEnablePreferCompositingToLCDText[] ="enable-prefer-compositing-to-lcd-text";// Enable one or more Blink runtime-enabled features.// Use names from runtime_enabled_features.json5, separated by commas.// Applied before kDisableBlinkFeatures, and after other flags that change these// features.const char kEnableBlinkFeatures[] = "enable-blink-features";// Enables Canvas 2D overlays for Windows.const char kEnableCanvas2dSwapChain[] = "enable-canvas2d-swap-chain";// Enable native caret browsing, in which a moveable cursor is placed on a web// page, allowing a user to select and navigate through non-editable text using// just a keyboard. See https:///977390 for links to i2i.const char kEnableCaretBrowsing[] = "enable-caret-browsing";// Enables experimental WebAssembly features.const char kEnableExperimentalWebAssemblyFeatures[] ="enable-experimental-webassembly-features";// Enables Web Platform features that are in development.const char kEnableExperimentalWebPlatformFeatures[] ="enable-experimental-web-platform-features";// Disables all RuntimeEnabledFeatures that can be enabled via OriginTrials.const char kDisableOriginTrialControlledBlinkFeatures[] ="disable-origin-trial-controlled-blink-features";// Specify that all compositor resources should be backed by GPU memory buffers. const char kEnableGpuMemoryBufferCompositorResources[] ="enable-gpu-memory-buffer-compositor-resources";// Enable GpuMemoryBuffer backed VideoFrames.const char kEnableGpuMemoryBufferVideoFrames[] ="enable-gpu-memory-buffer-video-frames";// When using CPU rasterizing generate low resolution tiling. Low res// tiles may be displayed during fast scrolls especially on slower devices.const char kEnableLowResTiling[] = "enable-low-res-tiling";// Force logging to be enabled. Logging is disabled by default in release// builds.const char kEnableLogging[] = "enable-logging";// Enables the type, downlinkMax attributes of the NetInfo API. Also, enables// triggering of change attribute of the NetInfo API when there is a change in// the connection type.const char kEnableNetworkInformationDownlinkMax[] ="enable-network-information-downlink-max";// Disables the video decoder from drawing to an NV12 textures instead of ARGB. const char kDisableNv12DxgiVideo[] = "disable-nv12-dxgi-video";// Enables testing features of the Plugin Placeholder. For internal use only.const char kEnablePluginPlaceholderTesting[] ="enable-plugin-placeholder-testing";// Make the values returned to window.performance.memory more granular and more // up to date in shared worker. Without this flag, the memory information is// still available, but it is bucketized and updated less frequently. This flag// also applys to workers.const char kEnablePreciseMemoryInfo[] = "enable-precise-memory-info";// Enables PrintBrowser mode, in which everything renders as though printed. const char kEnablePrintBrowser[] = "enable-print-browser";// Enables RGBA_4444 textures.const char kEnableRGBA4444Textures[] = "enable-rgba-4444-textures";// Set options to cache V8 data. (off, preparse data, or code)const char kV8CacheOptions[] = "v8-cache-options";// If true the ServiceProcessLauncher is used to launch services. This allows// for service binaries to be loaded rather than using the utility process. This// is only useful for tests.const char kEnableServiceBinaryLauncher[] = "enable-service-binary-launcher";// Enables the Skia benchmarking extensionconst char kEnableSkiaBenchmarking[] = "enable-skia-benchmarking";// On platforms that support it, enables smooth scroll animation.const char kEnableSmoothScrolling[] = "enable-smooth-scrolling";// Enable spatial navigationconst char kEnableSpatialNavigation[] = "enable-spatial-navigation";// Blocks all insecure requests from secure contexts, and prevents the user// from overriding that decision.const char kEnableStrictMixedContentChecking[] ="enable-strict-mixed-content-checking";// Blocks insecure usage of a number of powerful features (device orientation,// for example) that we haven't yet deprecated for the web at large.const char kEnableStrictPowerfulFeatureRestrictions[] ="enable-strict-powerful-feature-restrictions";// Feature flag to enable HTTPS subresource internal redirects to compressed// versions.const char kEnableSubresourceRedirect[] = "enable-subresource-redirect";// Enabled threaded compositing for web tests.const char kEnableThreadedCompositing[] = "enable-threaded-compositing";// Enable tracing during the execution of browser tests.const char kEnableTracing[] = "enable-tracing";// The filename to write the output of the test tracing to.const char kEnableTracingOutput[] = "enable-tracing-output";// Enable screen capturing support for MediaStream API.const char kEnableUserMediaScreenCapturing[] ="enable-usermedia-screen-capturing";// Enable the mode that uses zooming to implment device scale factor behavior. const char kEnableUseZoomForDSF[] = "enable-use-zoom-for-dsf";// Enables the use of the @viewport CSS rule, which allows// pages to control aspects of their own layout. This also turns on touch-screen// pinch gestures.const char kEnableViewport[] = "enable-viewport";// Enable the Vtune profiler support.const char kEnableVtune[] = "enable-vtune-support";// Enable the Web Authentication Testing API.//https://w3c.github.io/webauthnconst char kEnableWebAuthTestingAPI[] = "enable-web-authentication-testing-api"; // Enable WebGL2 Compute context.const char kEnableWebGL2ComputeContext[] = "enable-webgl2-compute-context"; // Enables WebGL extensions not yet approved by the community.const char kEnableWebGLDraftExtensions[] = "enable-webgl-draft-extensions";// Enables WebGL rendering into a scanout buffer for overlay support.const char kEnableWebGLImageChromium[] = "enable-webgl-image-chromium";// Enables interaction with virtual reality devices.const char kEnableWebVR[] = "enable-webvr";// Enable rasterizer that writes directly to GPU memory associated with tiles. const char kEnableZeroCopy[] = "enable-zero-copy";// Handle to the shared memory segment containing field trial state that is to// be shared between processes. The argument to this switch is the handle id// (pointer on Windows) as a string, followed by a comma, then the size of the// shared memory segment as a string.const char kFieldTrialHandle[] = "field-trial-handle";// Define an alias root directory which is replaced with the replacement string// in file URLs. The format is "/alias=/replacement", which would turn// file:///alias/some/path.html into file:///replacement/some/path.html.const char kFileUrlPathAlias[] = "file-url-path-alias";// Always use the Skia GPU backend for drawing layer tiles. Only valid with GPU // accelerated compositing + impl-side painting. Overrides the// kEnableGpuRasterization flag.const char kForceGpuRasterization[] = "force-gpu-rasterization";// Disables OOP rasterization. Takes precedence over the enable flag.const char kDisableOopRasterization[] = "disable-oop-rasterization";// Turns on out of process raster for the renderer whenever gpu raster// would have been used. Enables the chromium_raster_transport extension. const char kEnableOopRasterization[] = "enable-oop-rasterization";// Turns on skia deferred display list for out of process raster.const char kEnableOopRasterizationDDL[] = "enable-oop-rasterization-ddl";// Enables WebGL overlays for Windows.const char kEnableWebGLSwapChain[] = "enable-webgl-swap-chain";。
实验操作英语作文素材
实验操作英语作文素材Certainly, here's a composition on the topic of experimental procedures in English:---。
Experimental Procedures: A Crucial Aspect of Scientific Inquiry。
In the realm of scientific research, experimental procedures serve as the backbone of empirical investigation, facilitating the systematic exploration of hypotheses and the validation of scientific claims. Effective experimental procedures are characterized by meticulous planning,precise execution, and rigorous analysis, ensuring the reliability and validity of experimental findings. In this essay, we delve into the significance of experimental procedures and examine key elements that contribute totheir success.First and foremost, experimental procedures play a pivotal role in ensuring the reproducibility of scientific results. By providing detailed step-by-step instructions, researchers enable others to replicate their experiments and verify the robustness of their findings. Reproducibility fosters transparency and accountability in scientific research, allowing for independent validation and peer review. Moreover, it enhances the credibility of scientific knowledge by mitigating the risk of false or spurious claims.Furthermore, experimental procedures promote consistency and standardization in scientific practices. Standardized protocols enable researchers to control variables, minimize confounding factors, and maintain consistency across experimental conditions. This ensures the reliability of experimental results and facilitates comparison between different studies. Moreover, standardized procedures facilitate collaboration and knowledge exchange within the scientific community, fostering cumulative progress and innovation.Effective experimental procedures are characterized by careful attention to detail and adherence to best practices in experimental design. Prior to conducting experiments, researchers must formulate clear research questions,develop testable hypotheses, and design appropriate methodologies. This involves identifying relevant variables, selecting suitable measurement techniques, and devising controls to minimize bias and variability. Additionally, researchers must consider ethical considerations and ensure compliance with regulatory guidelines to safeguard the welfare of participants and the integrity of scientific research.During the experimental phase, meticulous execution is paramount to obtaining reliable results. Researchers must follow protocols precisely, record data accurately, and troubleshoot any unexpected challenges that arise.Attention to detail is crucial at every stage of the experiment, from preparation and calibration of equipmentto data collection and analysis. Rigorous documentation of procedures and outcomes facilitates transparency and reproducibility, allowing others to scrutinize and validatethe findings.After data collection, thorough analysis is essential to draw meaningful conclusions from the results.Statistical analysis techniques are employed to identify patterns, trends, and correlations within the data, enabling researchers to test hypotheses and infer causal relationships. Critical interpretation of findings requires consideration of potential limitations, alternative explanations, and implications for theory and practice. Moreover, researchers must communicate their findings effectively through peer-reviewed publications, presentations, and other dissemination channels to contribute to the advancement of scientific knowledge.In conclusion, experimental procedures are indispensable to the scientific method, serving as the foundation upon which empirical knowledge is built. By facilitating reproducibility, standardization, and rigor in scientific inquiry, experimental procedures contribute to the accumulation of reliable evidence and the advancement of human understanding. Through careful planning,meticulous execution, and critical analysis, researchers uphold the principles of scientific integrity and foster a culture of excellence in research.---。
RecommendationLetterSample
Contents of Recommendation letter:•Relationship of between the referral and the applicant•The strength of the applicant•The further improvement space of the applicant•(printed, or hand-written, and signed by the referral)Others:•One business cardfrom the referral•Signature on the sealed envelopeRecommendation Letter SampleTo Whom It May Concern:This letter is to serve as my formal recommendation for Andrew Fuller. Andrew has been my direct assistant for several years. He has been interested in obtaining an MBA degree for some time now and I feel that he would be an excellent candidate for your esteemed program.During his time here, Andrew has consistently demonstrated a strong work ethic and a dedication to success. His efforts have produced high quality results time and time again. Last year, Andrew developed and successfully implemented a plan to streamline our production department. The plan was a major undertaking, requiring a great deal of thought and effort on Andrew’s behalf.Though Andrew is my assistant, he is also in an unofficial leadership role. Many of his co-workers seek his advice and support. Andrew is always there for them and is quite comfortable in the role.I feel his budding leadership abilities will become even more effective in a business school setting.For these reasons, I highly recommend Andrew Fuller as a candidate for your MBA program. If you have any questions regarding Andrew or this recommendation, please contact me.Sincerely,(Signature)John Thomas Operations Manager Tri-State DirectoriesSample 2To Whom It May Concern:This letter is my personal recommendation for Cathy Douglas. Until just recently, I have been Cathy's immediate supervisor for several years. I found her to be consistently pleasant, tackling all assignments with dedication and a smile.Besides being a joy to work with, Cathy is a take-charge person who is able to present creative ideas and communicate the benefits. She has successfully developed several marketing plans for our company that have resulted in increased revenue. During her tenure, we saw an increase in profits that exceeded one million dollars. The new revenue was a direct result of the plans implemented by Cathy.Though she was an asset to our marketing efforts, Cathy was also extraordinarily helpful in other areas of the company. In addition to writing effective training modules for sales representatives, Cathy assumed a leadership role in sales meetings, inspiring and motivating other employees.I highly recommend Cathy for employment. She is a team player and would make a great asset to any organization.Sincerely,Sharon Feeney Marketing Manager ABC ProductionsSample 3To whom it may concern:I think extremely highly of Hongbin Wu, and therefore it is my great pleasure to write a letter of recommendation on his behalf, for entrance into your MBA program.I have known Hongbin for more than one and a half years. I hired him to work for me as a Research Analyst at SRR in July of 1996. SRR is a full-service marketing research firm whose clients are primarily large radio stations and other music oriented media companies such as Capital Records, and MTV Networks. My roles at SRR include manager of new product development (research products and the software to analyze the results), and internal research consultant (sampling methodology and multivariate statistical analysis). In addition, as a member of the management team at SRR, I am charged with constantly working to find more efficient, cost-effective means of gathering respondent level data and producing our research products. Since joining SRR as a Senior Research Analyst, and more recently as Manager of Research and Development, Hongbin has been a major weapon in my arsenal of tools for accomplishing thesetasks.Hongbin is a creative and original thinker. He has native intelligence, great curiosity about people and ideas, and plenty of common sense that he has applied to solving many problems at SRR. In addition, he has demonstrated excellent powers of observation, and an ability to communicate and suggest change in effective but non-threatening ways. To illustrate…Early on, Hongbin was assigned to an important research project as a fill-in Project Manager. In this role he was responsible for the technical aspects of creating a computer-based survey questionnaire (from one given to him by our client services department), monitoring the telephone data collection process, and completing the data processing and analysis of the survey results.From the beginning of this assignment, Hongbin began to re-define our expectations of a good project manager. He started by participating in discussions with the client and suggesting and implementing several changes to the script that shortened its length and clarified the instructions to respondents. Without prompting or precedence he spent several days working odd hours, observing and monitoring interviewers and supervisors as they began to field this 2000 person study. Within a few days he had shortened and clarified the script even more - removing redundant questions, collapsing multiple questions into one, and improving the flow from question to question and screen-to-screen - all to the great praise of both interviewers and the director of our phone center. He had also observed something about a particular aspect of the interviewing process that was common to all surveys at SRR. He wrote a memo to several managers outlining his proposed change in methodology that clearly demonstrated the value of his idea: an annual cost reduction of close to $50,000. At the end of the project, he wrote a several page critique of our interviewing and supervisory staff. He described the characteristics and skills employed by the best interviewers he'd observed and made suggestions for how these skills could be taught to the entire staff. His recommendations were well received and soon implemented by the very manager whose staff was being critiqued; such was the value of his contribution and the skill and sensitivity with which he presented his ideas.In processing the survey results, Hongbin also quickly learned to use several advanced statistical techniques including Cluster Analysis and Discriminant Analysis with which he had only a passing knowledge prior to the project.Hongbin has also demonstrated his technical and analytical abilities in helping create a new model for bidding on new business, and in spearheading the development of tool that used a Maximum Likelihood algorithm for ascribing missing respondent data. Recently, Hongbin helped me identify the most desirable qualifications and background of computer programming candidates, and he assisted me in the recruiting and mentoring of two Chinese student interns to this position. They have both made significant contributions in only a few months of employment.Hongbin is not a native English speaker or writer, and thus, he has had to work very hard to clearly communicate his ideas. I have seen him grow in this area tremendously over the last one and half years. His attentive listening and great enthusiasm has helped him overcome anylanguage limitations. He is both self-confident and self-deprecating, and has a great sense of humor that has helped him form strong relationships with subordinates, peers, and members of our management team. Managers in other departments frequently seek his advice, and his name is always at the top of the list when choosing team members to spearhead important company initiatives.In all of these areas, Hongbin Wu has gone beyond expectations, and has out-shined all others in his peer-group at SRR. His efforts were recently rewarded with a promotion to the position of Manager of Research & Development.Hongbin is very likeable and ambitious person. I have no doubt that he will be a serious and enthusiastic student, and someday a quite successful senior level manager or entrepreneur that you would be proud to call an alumni.Sincerely,Mark PetermanVice PresidentSRRAbstracted from an article, PLS as reference:In what context and for how long have you known the applicant? Please comment on the frequency of interaction. Please give exact dates. Is this person still emplo yed by your organization?In your answers, please describe specific activities or accomplishments that demonst rate this candidate\'s strengths and weaknesses.1. What are the applicant\'s principal strengths and special talents? / Provide a sho rt list of adjectives that describe the applicant\'s strengths.2. Discuss the applicant\'s competence in his area of responsibility or specialization(i.e. organizational skills, attention to detail, ability to complete assignments).3. How does the applicant\'s performance compare with that of his or her peers? How does he accept constructive criticism? How has the applicant grown during his employment with you?4. Comment on the applicant\'s ability to work with others, including superiors, pee rs and subordinates. Would you enjoy working for the applicant? / Please discuss o bservations you have made concerning the applicant\'s leadership abilities and group skills.5. Comment on the applicant\'s maturity.6. How would you describe the applicant\'s sense of humor?7. In what ways could the applicant improve professionally? / What aspect of the applicant would you most like to change? / In which areas could the applicant exhi bit growth or improvement? Has he worked on these areas?8. How well has the applicant made use of available opportunities? Consider his ini tiative, curiosity and motivation.9. What do you think motivates the candidate\'s application to the MBA program? Do you feel the applicant is realistic in his professional ambitions? / Has the applica nt given careful consideration to his plans for entry into the MBA program? / Please comment on your impression of the applicant\'s capacity for graduate work.10. Comment on the applicant\'s business ethics.11. What is your overall assessment of the applicant\'s potential for success as an effective and inspiring upper-level manager?12. Please provide detailed comments on the applicant\'s degree of self-confidence.Feel free to make additional statements concerning the applicant\'s accomplishments, managerial potential and other personal qualities. / Comments regarding the applic ant\'s aptitude for graduate work and a career in business and management will be especially appreciated.Don\'t try to address every issue on the page; instead, pick those that show you in the best light. Start by writing a brief answer to each question. Only after you h ave good replies should you worry about fitting them together into a coherent lette r.。
良好的实验动物给药和采血(包括途径和体积)规范指南
A Good Practice Guide to the Administration of Substances and Removal of Blood,Including Routes andVolumes良好的实验动物给药和采血(包括途径和体积)规范指南Karl-Heinz Diehl1, Robin Hull2, David Morton3, Rudolf Pfister4, Yvon Rabemampianina5,David Smith6,*, Jean-Marc Vidal7 and Cor van de V orstenbosch 81Aventis, PO Box 1140, D35001 Marburg, Germany德国马尔堡市35001区1140信箱安万特公司2N I B S C, Blanch Lane, South Miimms, Potters Bar, Hertfordshire EN6 3QG英国赫特福德郡EN6 3QG波特斯巴镇South Miimms布兰奇道英国国家生物制品检定所3The University of Birmingham, Medical School, Edgbaston, Birmingham B15 2TT英国伯明翰市B15 2TT艾吉马斯顿伯明翰大学医学院4Novartis Pharma AG, CH-4002 Basel, Switzerland瑞士巴塞尔CH-4002诺华制药公司5Centre de Recherche Pfizer, Etablissement d’Amboise, Z1 Poce´-sur-Cisse-BP 159 37401 Amboise Cedex, France法国Amboise Cedex Z1 Poce´-sur-Cisse-BP 159 37401 Etablissement d’Amboise 辉瑞研究中心6AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics LE11 5RH英国莱斯特郡LE11 5RH拉夫堡市贝克韦尔路Charnwood阿斯利康研究中心7Aventis, 102 Route de Noisy, 95235 Romainville Ce´dex, France法国Romainville Ce´dex 95235 Noisy路102号安万特公司8N V Organon, PO Box 20, 5340 BH Oss, Netherlands荷兰BH Oss5340 20号信箱欧加农公司Key words: blood volumes; blood removal; administration substances; laboratory animals; refinement.关键词:血容量;采血;给药;实验动物;简化This article is the result of an initiative between the European Federation of Pharmaceutical Industries Associations (EFPIA) and the European Centre for the Validation of Alternative Methods (ECV AM).Its objectives are to provide the researcher in the safety evaluation laboratory with an up-to-date, easyto-use set of data sheets to aid in the study design process whilst at the same time affording maximum welfare considerations to the experimental animals.该文章为欧盟制药工业协会(EFPIA)和欧洲替代动物实验方法验证中心(ECV AM)之间的初步结果。
大分子 投稿要求
12016 Guidelines for Authors(Revised January 2016)Submission ChecklistBefore submitting your manuscript, please check your submission for the following:□ Manuscripts should be submitted via the ACS Paragon Plus Environment(/login ) and all co-authors should be entered into ACS Paragon Plus with contact information and e-mail addresses for each.□ Title should not include words such as “First”, “Novel”, “New”, and serial numbers are not allowed.□ A brief Abstract (100–150 words) should be included with all manuscript types.□ The entire manuscript text should be double-spaced.□ Table of Contents (TOC) graphic a. A TOC graphic (color encouraged) should be provided, preferably near the abstract of the manuscript , with the page labeled as “for Table of Contents use only”, and the title and author list.b. The illustration should be visually appealing, and highlight the most important aspect of the work.c. The graphic should be provided in the actual size to be used that will fit in an area 3.25in. wide by 1.375 in. high (8.3 cm × 3.5 cm).□ Figures and Tablesa. Should be embedded within the manuscript text at their first reference, at a nearby paragraph break.b. For best results, figures and tables should be submitted at final published size (i.e., 3.25 in. wide for one column).两倍行距摘要部分添加图片,说明题目和作者列表图要生动形象,突出实验重点图片格式第一引用的图表需要在段落附近出现,并且按照最后提交的格式进行修改2□ Supporting Information (SI)a. All nonessential figures, tables, and procedures should be included as SI and uploaded asa separate file (pdf recommended) at the same time as manuscript submission.b. The availability of SI should be mentioned in a separate paragraph in the manuscript,placed immediately before the references, as: “Supporting Information . Brief statement in nonsentence format listing the contents of the material supplied as SupportingInformation.”The uploaded files (Manuscript file + Graphic(s) for manuscript) will be converted into a PDF proof. This is how the manuscript will appear when sent to reviewers. This PDF proof must be viewed and validated before submission is completed. Authors are also encouraged to upload their own pdf version of the manuscript. Submission of ManuscriptsManuscripts must be submitted via the ACS Paragon Plus Environment (/login ). Complete instructions and an overview of the electronic online (Web) submission process are available through the secure ACS Paragon Plus Web site. Authors must also submit all revisions of manuscripts via the ACS Paragon Plus Environment. The Web submission site employs state-of-the-art security mechanisms to ensure that all electronically submitted papers are secure. These same security mechanisms are also utilized throughout the peer-review process, permitting access only to editors and reviewers who are assigned to a particular paper .The entire manuscript (including abstract, references, tables, and figure legends) should be double-spaced . All pages should be numbered consecutively. Sequences of figures, tables, charts, and schemes should also be numbered, with Arabic numerals. Patent Activities and Intellectual Property Issues. Authors are responsible for ensuring that all patent activities and intellectual property issues are satisfactorily resolved prior to first publication (ASAP or in issue). Acceptance and publication will not be delayed for pending or unresolved issues of this nature.Preparation of ManuscriptAuthors should write in clear, concise English and follow the style of headings in a current issue of Macromolecules . Foreign authors should have the spelling, grammar, and style checked by someone fully proficient in the English language. Assistance with English Language Editing. Authors may want to have their manuscripts edited professionally before submission to improve clarity. The ACS ChemWorx English Editing Service can assist you in improving and polishing the language in your manuscript. You can learn more about the services offered, at .Journal Publishing Agreement. A properly completed and signed Journal PublishingAgreement must be submitted for each manuscript. ACS Paragon Plus provides an electronic version of the Agreement that will be available on the My Authoring Activity tab of theCorresponding Author's Home page once the manuscript has been assigned to an Editor. A PDF version of the Agreement is also available, but Authors are strongly encouraged to use the转换成PDF格式上传通过这个网站提交手稿摘要,参考文献,图表阐述都要两倍行距,所有页面、图片、表、计划等都要用阿拉伯数字编号英语表达无误3electronic Journal Publishing Agreement. If the PDF version is used, all pages of the signed PDF Agreement must be submitted. If the Corresponding Author cannot or should notcomplete either the electronic or PDF version for any reason, another Author should complete and sign the PDF version of the form. Forms and complete instructions are available at /page/copyright/journals/index.html . Conflict of Interest Disclosure. A statement describing any financial conflicts of interest or lack thereof is published with each manuscript. During the submission process, the corresponding author must provide this statement on behalf of all authors of the manuscript. The statement should describe all potential sources of bias, including affiliations, funding sources, and financial or management relationships, that may constitute conflicts of interest (please see the ACS Ethical Guidelines ). The statement will be published in the final article. If no conflict of interest is declared, the following statement will be published in the article: “The authors d eclare no competing financial interest.”Funding Sources. When submitting a manuscript to the Journal via ACS Paragon Plus, the submitting author is asked to identify the funding sources for the work presented in the manuscript. Identifying funding sources is optional during submission of an original manuscript. Funding source information is required when a revised manuscript is submitted.Professional Ethics. In publishing only original research, ACS is committed to deterring plagiarism, including self-plagiarism. ACS Publications uses CrossCheck's iThenticate software to screen submitted manuscripts for similarity to published material. Note that your manuscriptmay be screened during the submission process. Further information about plagiarism can be found in Part B of the Ethical Guidelines to Publication of Chemical Research .Author List. During manuscript submission, the submitting author must provide contact information (full name, email address, institutional affiliation and mailing address) for all of theco-authors. Because all of the author names are automatically imported into the electronic Journal Publishing Agreement, the names must be entered into ACS Paragon Plus in the same sequence as they appear on the first page of the manuscript. (Note that co-authors are not required to register in ACS Paragon Plus.) The author who submits the manuscript forpublication accepts the responsibility of notifying all co-authors that the manuscript is being submitted. Deletion of an author after the manuscript has been submitted requires a confirming letter to the Editor-in-Chief from the author whose name is being deleted. For more information on ethical responsibilities of authors, see the Ethical Guidelines to Publication of Chemical Research .ORCID. All authors are encouraged to register for an ORCID iD, a unique researcher identifier. With this standard identifier, you can create a profile of your research activities to distinguish yourself from other researchers with similar names, and make it easier for your colleagues to find your publications. Learn more at . Authors and reviewers can add their ORCID iD to, or register for an ORCID iD from, their account in ACS Paragon Plus.Table of Contents Graphic for Submissions. A Table of Contents (TOC) graphic is required for all papers when first submitted to Macromolecules . This graphic will also be published in the Abstract. The graphic should capture the reader’s attention and, in conjunction with themanuscript title, give the reader a quick visual impression of the essence of the paper. Examples作者签署同意发表协议提交声明,说明研究机构、资金支持等需要鉴别资金支持禁止剽窃和自我剽窃,稿件提交后将会进行学术不端检查提交论文时,提交者要把其他作者的相关信息一并提交4include structures, graphs, drawings, SEM/TEM/AFM images, or reaction schemes. Tables or spectra are not usually appropriate. Color is encouraged and will be free of charge. The author should submit a graphic in the actual size to be used for the TOC, fitting in an area no larger than3.25 in. × 1.375 in. (8.3 cm × 3.5 cm). Larger images will be reduced to fit within thosedimensions. Type size of labels, formulas, or numbers within the graphic must be legible. Thepage should be labeled “for Table of Contents use only” and contain the title and authors of the paper. This item should be appended as the last page of the manuscript. Title. Titles should clearly and concisely reflect the emphasis and content of the paper. Titles are of great importance for current awareness and information retrieval and should be carefullyconst ructed for these purposes. Please note that the use of serial numerals in the title (e.g., “broad topic. 3. specific subject”) is no longer permitted. Author List. Bylines should include all those who have made substantial contributions to the work. All coauthors need to be included during the submission process. To facilitate indexing and retrieval and for unique identification of an author, use first names, initials, and surnames(e.g., John R. Smith) or first initials, second names, and surnames (e.g., J. Robert Smith). At least one author must be designated with an asterisk as the person to whom correspondence should be addressed. An abstract must be provided for all submissions. For full-length articles, use between 100 and 150 words in complete, concise sentences to indicate what is new, different, and significant. The abstract should be presented in a findings-oriented format; that is, one in which the first sentence is a succinct, informative summation of the most important results and conclusions. Theremainder should highlight pertinent supporting details, related findings, types or classes ofcompounds investigated, and methods used. The abstract should be self-contained for direct use in Chemical Abstracts or other secondary services. For shorter papers, abstracts should be correspondingly brief.The Experimental Section should provide a clear, unambiguous description of materials, methods, and equipment in sufficient detail to permit repetition of the work elsewhere.Repetitive descriptions of a general procedure should be avoided. Precautions for handling dangerous material or for performing hazardous procedures should be explicitly stated .NMR Spectral Data. If you are reporting NMR data, please refer to ACS's guidelines onsubmitting NMR data: /page/4authors/tools/index.html . References. It is the responsibility of authors to ensure the accuracy of references. Because subscribers to the Web edition of the journal are now able to click on the “CAS” tag following each reference to retrieve the corresponding CAS abstract, reference accuracy is critical.Starting in 2016, authors are actively encouraged, and will eventually be required, to include article titles within the references. References should be typed in the format of Macromolecules (see below) and cited in the text by superscript numbers without parentheses or spaces. When more than one reference is cited in one place, separate the numbers by commas without spaces. Authors should consult the Journal Web site available via as a guide to proper format. Information on a standard list of abbreviations for ACS journals may be found in TheACS Style Guide (3rd ed., 2006), available from Oxford University Press, Order Department, 201 Evans Road, Cary, NC 27513. 摘要中的图可以是SEM,TEM,AFM图,或者反应图,但是不能是表格或者光谱较大的图像将被缩小以适合这些尺寸内。
Plant Cell Reports投稿指南,投稿要求
Instructions for AuthorsTYPES OF PAPERSThe journal publishes original and focus articles, reviews and opinion papers.Information for Review AuthorsPlant Cell Reports publishes timely reviews on major developments in all areas of plant cell biology. Prospective authors may provide a short outline (one or two pages) of the proposed review.The general instructions for authors should be used for all technical aspects of manuscript preparation. The "Materials and methods" and "Results" sections are not needed, but please give an introduction before proceeding to the details and use informative headings for the different parts of your review. Reviews should not be longer than seven printed pages, including references, tables, and figures (approx. 21 manuscript pages, or 5,000 words).Review Authors will not be charged for printing essential color figures.Information on Focus contributionsFocus articles are short commentaries, experimental advances, methods, or opinion papers of no more than 1000 words and 5 references, max. one figure or table. Focus articles are intended for fast-track publication; an abstract is not needed.Biographical summaryAuthors of Reviews, Focus Papers and Guest Editorials are invited to supply a brief biographical summary (between 50 and 100 words) and a black and white glossy photograph, passport-sized. MANUSCRIPT SUBMISSIONManuscript SubmissionSubmission of a manuscript implies: that the work described has not been published before; that it is not under consideration for publication anywhere else; that its publication has been approved by all co-authors, if any, as well as by the responsible authorities – tacitly or explicitly – at the institute where the work has been carried out. The publisher will not be held legally responsible should there be any claims for compensation.PermissionsAuthors wishing to include figures, tables, or text passages that have already been published elsewhere are required to obtain permission from the copyright owner(s) for both the print and online format and to include evidence that such permission has been granted when submitting their papers. Any material received without such evidence will be assumed to originate from the authors.Online SubmissionAuthors should submit their manuscripts online. Electronic submission substantially reduces the editorial processing and reviewing times and shortens overall publication times. Please follow the hyperlink “Submit online” on the right and upload all of your manuscript files following the instructions given on the screen.AUTHOR CONTRIBUTION STATEMENTAuthors must provide a short description of the contributions made by each listed author (please use initials). This will be published in a separate section in front of the Acknowledgments.•Example: AM and DB conceived and designed research. AM and BB conducted experiments.GR contributed new reagents or analytical tools. AM and GR analyzed data. AM wrote themanuscript. All authors read and approved the manuscript.Note by the editors:Please be aware that changes to the list of authors are not possible after final acceptance of themanuscript.The International Committee of Medical Journal Editors has advice on what constitutes properauthorship:•ICMJE adviceLANGUAGEManuscripts that are accepted for publication will be checked by our copyeditors for spelling and formal style. This may not be sufficient if English is not your native language and substantial editing would be required. In that case, you may want to ask a native speaker to help you or arrange for your manuscript to be checked by a professional language editor prior to submission. A clear and concise language will help editors and reviewers concentrate on the scientific content of your paper and thus smooth the peer review process.The following editing service provides language editing for scientific articles in medicine, biomedical and life sciences, chemistry, physics, engineering, business/economics, and humanities•Edanz Editing GlobalPlease contact the editing service directly to make arrangements for editing and payment.Use of an editing service is neither a requirement nor a guarantee of acceptance for publication.TITLE PAGETitle PageThe title page should include:•The name(s) of the author(s)• A concise and informative title•The affiliation(s) and address(es) of the author(s)•The e-mail address, telephone and fax numbers of the corresponding authorAbstractPlease provide an abstract of 150 to 250 words. The abstract should not contain any undefinedabbreviations or unspecified references.KeywordsPlease provide 4 to 6 keywords which can be used for indexing purposes.KEY MESSAGE•Please summarize the main achievement of your manuscript beyond the meaning of the manuscript title. This "Key Message" may not contain more than 30 words, and is essential fororiginal research papers only. It is not needed for Reviews and Opinion Papers.TEXTText FormattingManuscripts should be submitted in Word.•Use a normal, plain font (e.g., 10-point Times Roman) for text.•Use italics for emphasis.•Use the automatic page numbering function to number the pages.•Do not use field functions.•Use tab stops or other commands for indents, not the space bar.•Use the table function, not spreadsheets, to make tables.•Use the equation editor or MathType for equations.•Save your file in docx format (Word 2007 or higher) or doc format (older Word versions).Manuscripts with mathematical content can also be submitted in LaTeX.•LaTeX macro package (zip, 182 kB)HeadingsPlease use no more than three levels of displayed headings.AbbreviationsAbbreviations should be defined at first mention and used consistently thereafter.FootnotesFootnotes can be used to give additional information, which may include the citation of a reference included in the reference list. They should not consist solely of a reference citation, and they should never include the bibliographic details of a reference. They should also not contain any figures or tables.Footnotes to the text are numbered consecutively; those to tables should be indicated by superscript lower-case letters (or asterisks for significance values and other statistical data). Footnotes to the title or the authors of the article are not given reference symbols.Always use footnotes instead of endnotes.AcknowledgmentsAcknowledgments of people, grants, funds, etc. should be placed in a separate section before thereference list. The names of funding organizations should be written in full.SCIENTIFIC STYLEGenus and species names should be in italics.REFERENCESCitationCite references in the text by name and year in parentheses. Some examples:•Negotiation research spans many disciplines (Thompson 1990).•This result was later contradicted by Becker and Seligman (1996).•This effect has been widely studied (Abbott 1991; Barakat et al. 1995; Kelso and Smith 1998;Medvec et al. 1999).Reference listThe list of references should only include works that are cited in the text and that have been published or accepted for publication. Personal communications and unpublished works should only be mentioned in the text. Do not use footnotes or endnotes as a substitute for a reference list.Reference list entries should be alphabetized by the last names of the first author of each work.•Journal articleGamelin FX, Baquet G, Berthoin S, Thevenet D, Nourry C, Nottin S, Bosquet L (2009) Effectof high intensity intermittent training on heart rate variability in prepubescent children. Eur JAppl Physiol 105:731-738. doi: 10.1007/s00421-008-0955-8Ideally, the names of all authors should be provided, but the usage of “et al” in long authorlists will also be accepted:Smith J, Jones M Jr, Houghton L et al (1999) Future of health insurance. N Engl J Med965:325–329•Article by DOISlifka MK, Whitton JL (2000) Clinical implications of dysregulated cytokine production. J MolMed. doi:10.1007/s001090000086•BookSouth J, Blass B (2001) The future of modern genomics. Blackwell, London •Book chapterBrown B, Aaron M (2001) The politics of nature. In: Smith J (ed) The rise of moderngenomics, 3rd edn. Wiley, New York, pp 230-257•Online documentCartwright J (2007) Big stars have weather too. IOP Publishing PhysicsWeb./articles/news/11/6/16/1. Accessed 26 June 2007•DissertationTrent JW (1975) Experimental acute renal failure. Dissertation, University of California Always use the standard abbreviation of a journal’s name according to the ISSN List of Title Word Abbreviations, see• LTWAIf you are unsure, please use the full journal title.For authors using EndNote, Springer provides an output style that supports the formatting of in-text citations and reference list.•EndNote style (zip, 2 kB)TABLES•All tables are to be numbered using Arabic numerals.•Tables should always be cited in text in consecutive numerical order.•For each table, please supply a table caption (title) explaining the components of the table.•Identify any previously published material by giving the original source in the form of a reference at the end of the table caption.•Footnotes to tables should be indicated by superscript lower-case letters (or asterisks for significance values and other statistical data) and included beneath the table body.ARTWORK AND ILLUSTRATIONS GUIDELINESElectronic Figure Submission•Supply all figures electronically.•Indicate what graphics program was used to create the artwork.•For vector graphics, the preferred format is EPS; for halftones, please use TIFF format.MSOffice files are also acceptable.•Vector graphics containing fonts must have the fonts embedded in the files.•Name your figure files with "Fig" and the figure number, e.g., Fig1.eps.Line Art•Definition: Black and white graphic with no shading.•Do not use faint lines and/or lettering and check that all lines and lettering within the figures are legible at final size.•All lines should be at least 0.1 mm (0.3 pt) wide.•Scanned line drawings and line drawings in bitmap format should have a minimum resolution of 1200 dpi.•Vector graphics containing fonts must have the fonts embedded in the files.Halftone Art•Definition: Photographs, drawings, or paintings with fine shading, etc.•If any magnification is used in the photographs, indicate this by using scale bars within the figures themselves.•Halftones should have a minimum resolution of 300 dpi.Combination Art•Definition: a combination of halftone and line art, e.g., halftones containing line drawing, extensive lettering, color diagrams, etc.•Combination artwork should have a minimum resolution of 600 dpi.Color Art•Color art is free of charge for online publication.•If black and white will be shown in the print version, make sure that the main information will still be visible. Many colors are not distinguishable from one another when converted to black and white. A simple way to check this is to make a xerographic copy to see if the necessarydistinctions between the different colors are still apparent.•If the figures will be printed in black and white, do not refer to color in the captions.•Color illustrations should be submitted as RGB (8 bits per channel).Figure Lettering•To add lettering, it is best to use Helvetica or Arial (sans serif fonts).•Keep lettering consistently sized throughout your final-sized artwork, usually about 2–3 mm (8–12 pt).•Variance of type size within an illustration should be minimal, e.g., do not use 8-pt type on an axis and 20-pt type for the axis label.•Avoid effects such as shading, outline letters, etc.•Do not include titles or captions within your illustrations.Figure Numbering•All figures are to be numbered using Arabic numerals.•Figures should always be cited in text in consecutive numerical order.•Figure parts should be denoted by lowercase letters (a, b, c, etc.).•If an appendix appears in your article and it contains one or more figures, continue the consecutive numbering of the main text. Do not number the appendix figures,"A1, A2, A3, etc." Figures in online appendices (Electronic Supplementary Material) should, however, be numbered separately.Figure Captions•Each figure should have a concise caption describing accurately what the figure depicts.Include the captions in the text file of the manuscript, not in the figure file.•Figure captions begin with the term Fig. in bold type, followed by the figure number, also in bold type.•No punctuation is to be included after the number, nor is any punctuation to be placed at the end of the caption.•Identify all elements found in the figure in the figure caption; and use boxes, circles, etc., as coordinate points in graphs.•Identify previously published material by giving the original source in the form of a reference citation at the end of the figure caption.Figure Placement and Size•When preparing your figures, size figures to fit in the column width.•For most journals the figures should be 39 mm, 84 mm, 129 mm, or 174 mm wide and not higher than 234 mm.•For books and book-sized journals, the figures should be 80 mm or 122 mm wide and not higher than 198 mm.PermissionsIf you include figures that have already been published elsewhere, you must obtain permission from the copyright owner(s) for both the print and online format. Please be aware that some publishers do not grant electronic rights for free and that Springer will not be able to refund any costs that may have occurred to receive these permissions. In such cases, material from other sources should be used.AccessibilityIn order to give people of all abilities and disabilities access to the content of your figures, please make sure that•All figures have descriptive captions (blind users could then use a text-to-speech software or a text-to-Braille hardware)•Patterns are used instead of or in addition to colors for conveying information (colorblind users would then be able to distinguish the visual elements)•Any figure lettering has a contrast ratio of at least 4.5:1IMAGE MANIPULATIONWith regard to image manipulation it is allowed to technically improve images for readability. •Proper technical manipulation refers to adjusting the contrast and/or brightness or color balance if it is applied to the complete digital image (and not parts of the image).Any technical manipulation by the author should be notified in the cover letter to the JournalEditor upon submission.•Improper technical manipulation refers to obscuring, enhancing, deleting and/or introducing new elements into an image.If the original data cannot be produced by an author when asked to provide it, acceptance of themanuscript may be revoked.Please read PCR’s free Focus paper on•''Images and imagination: the role of figures in plant cell and molecular biology publications” byC. Neal Stewart Jr.ELECTRONIC SUPPLEMENTARY MATERIAL•SubmissionSupply all supplementary material in standard file formats.Please include in each file the following information: article title, journal name, author names;affiliation and e-mail address of the corresponding author.To accommodate user downloads, please keep in mind that larger-sized files may requirevery long download times and that some users may experience other problems duringdownloading.•Audio, Video, and AnimationsAlways use MPEG-1 (.mpg) format.•Text and PresentationsPlease note that PDF-files are not allowed for submission.•SpreadsheetsSpreadsheets should be submitted as .xls files (MS Excel).•Specialized FormatsSpecialized format such as .pdb (chemical), .wrl (VRML), .nb (Mathematica notebook),and .tex can also be supplied.•Collecting Multiple FilesIt is possible to collect multiple files in a .zip or .gz file.•NumberingIf supplying any supplementary material, the text must make specific mention of the materialas a citation, similar to that of figures and tables.Refer to the supplementary files as “Online Resource”, e.g., "... as shown in the animation(Online Resource 3)", “... additional data are given in Online Resource 4”.Name the files consecutively, e.g. “ESM_3.mpg”, “ESM_4.pdf”.•CaptionsFor each supplementary material, please supply a concise caption describing the content ofthe file.•Processing of supplementary filesElectronic supplementary material will be published as received from the author without anyconversion, editing, or reformatting.•AccessibilityIn order to give people of all abilities and disabilities access to the content of yoursupplementary files, please make sure thatThe manuscript contains a descriptive caption for each supplementary materialVideo files do not contain anything that flashes more than three times per second (so thatusers prone to seizures caused by such effects are not put at risk)ETHICAL RESPONSIBILITIES OF AUTHORSThis journal is committed to upholding the integrity of the scientific record. As a member of the Committee on Publication Ethics (COPE) the journal will follow the COPE guidelines on how to deal with potential acts of misconduct.Authors should refrain from misrepresenting research results which could damage the trust in the journal, the professionalism of scientific authorship, and ultimately the entire scientific endeavour. Maintaining integrity of the research and its presentation can be achieved by following the rules of good scientific practice, which include:•The manuscript has not been submitted to more than one journal for simultaneous consideration.•The manuscript has not been published previously (partly or in full), unless the new work concerns an expansion of previous work (please provide transparency on the re-use ofmaterial to avoid the hint of text-recycling (“self-plagiarism”)).• A single study is not split up into several parts to increase the quantity of submissions and submitted to various journals or to one journal over time (e.g. “salami-publishing”).•No data have been fabricated or manipulated (including images) to support your conclusions•No data, text, or theories by others are presented as if they were the author’s own (“plagiarism”). Proper acknowledgements to other works must be given (this includesmaterial that is closely copied (near verbatim), summarized and/or paraphrased), quotationmarks are used for verbatim copying of material, and permissions are secured for materialthat is copyrighted.Important note: the journal may use software to screen for plagiarism.•Consent to submit has been received explicitly from all co-authors, as well as from the responsible authorities - tacitly or explicitly - at the institute/organization where the work hasbeen carried out, before the work is submitted.•Authors whose names appear on the submission have contributed sufficiently to the scientific work and therefore share collective responsibility and accountability for the results.In addition:•Changes of authorship or in the order of authors are not accepted after acceptance of a manuscript.•Requesting to add or delete authors at revision stage, proof stage, or after publication is a serious matter and may be considered when justifiably warranted. Justification for changes inauthorship must be compelling and may be considered only after receipt of written approvalfrom all authors and a convincing, detailed explanation about the role/deletion of thenew/deleted author. In case of changes at revision stage, a letter must accompany the revisedmanuscript. In case of changes after acceptance or publication, the request and documentationmust be sent via the Publisher to the Editor-in-Chief. In all cases, further documentation may berequired to support your request. The decision on accepting the change rests with the Editor-in-Chief of the journal and may be turned down. Therefore authors are strongly advised to ensurethe correct author group, corresponding author, and order of authors at submission.•Upon request authors should be prepared to send relevant documentation or data in order to verify the validity of the results. This could be in the form of raw data, samples, records, etc.If there is a suspicion of misconduct, the journal will carry out an investigation following the COPEguidelines. If, after investigation, the allegation seems to raise valid concerns, the accused author will be contacted and given an opportunity to address the issue. If misconduct has been established beyond reasonable doubt, this may result in the Editor-in-Chief’s implementation of the following measures, including, but not limited to:•If the article is still under consideration, it may be rejected and returned to the author.•If the article has already been published online, depending on the nature and severity of the infraction, either an erratum will be placed with the article or in severe cases complete retractionof the article will occur. The reason must be given in the published erratum or retraction note.•The author’s institution may be informed.COMPLIANCE WITH ETHICAL STANDARDSTo ensure objectivity and transparency in research and to ensure that accepted principles of ethical and professional conduct have been followed, authors should include information regarding sources offunding, potential conflicts of interest (financial or non-financial), informed consent if the researchinvolved human participants, and a statement on welfare of animals if the research involved animals.Authors should include the following statements (if applicable) in a separate section entitled“Compliance with Ethical Standards” before the References when submitting a paper:•Disclosure of potential conflicts of interest•Research involving Human Participants and/or Animals•Informed consentPlease note that standards could vary slightly per journal dependent on their peer review policies (i.e.double blind peer review) as well as per journal subject discipline. Before submitting your article check the Instructions for Authors carefully.The corresponding author should be prepared to collect documentation of compliance with ethicalstandards and send if requested during peer review or after publication.The Editors reserve the right to reject manuscripts that do not comply with the above-mentionedguidelines. The author will be held responsible for false statements or failure to fulfill the above-mentioned guidelines.DISCLOSURE OF POTENTIAL CONFLICTS OF INTERESTAuthors must disclose all relationships or interests that could have direct or potential influence or impart bias on the work. Although an author may not feel there is any conflict, disclosure of relationships and interests provides a more complete and transparent process, leading to an accurate and objective assessment of the work. Awareness of a real or perceived conflicts of interest is a perspective to which the readers are entitled. This is not meant to imply that a financial relationship with an organization that sponsored the research or compensation received for consultancy work is inappropriate. Examples of potential conflicts of interests that are directly or indirectly related to the research may include but are not limited to the following:•Research grants from funding agencies (please give the research funder and the grant number)•Honoraria for speaking at symposia•Financial support for attending symposia•Financial support for educational programs•Employment or consultation•Support from a project sponsor•Position on advisory board or board of directors or other type of management relationships•Multiple affiliations•Financial relationships, for example equity ownership or investment interest•Intellectual property rights (e.g. patents, copyrights and royalties from such rights)•Holdings of spouse and/or children that may have financial interest in the workIn addition, interests that go beyond financial interests and compensation (non-financial interests) that may be important to readers should be disclosed. These may include but are not limited to personal relationships or competing interests directly or indirectly tied to this research, or professional interests or personal beliefs that may influence your research.The corresponding author collects the conflict of interest disclosure forms from all authors. In author collaborations where formal agreements for representation allow it, it is sufficient for the corresponding author to sign the disclosure form on behalf of all authors. Examples of forms can be found•here:The corresponding author will include a summary statement in the text of the manuscript in a separate section before the reference list, that reflects what is recorded in the potential conflict of interestdisclosure form(s).See below examples of disclosures:Funding: This study was funded by X (grant number X).Conflict of Interest: Author A has received research grants from Company A. Author B has received a speaker honorarium from Company X and owns stock in Company Y. Author C is a member ofcommittee Z.If no conflict exists, the authors should state:Conflict of Interest: The authors declare that they have no conflict of interest.AFTER ACCEPTANCEUpon acceptance of your article you will receive a link to the special Author Query Application atSpringer’s web page where you can sign the Copyright Transfer Statement online and indicate whether you wish to order OpenChoice, offprints, or printing of figures in color.Once the Author Query Application has been completed, your article will be processed and you will receive the proofs.Open ChoiceIn addition to the normal publication process (whereby an article is submitted to the journal and access to that article is granted to customers who have purchased a subscription), Springer provides analternative publishing option: Springer Open Choice. A Springer Open Choice article receives all the benefits of a regular subscription-based article, but in addition is made available publicly throughSpringer’s online platform SpringerLink.•Springer Open ChoiceCopyright transferAuthors will be asked to transfer copyright of the article to the Publisher (or grant the Publisher exclusive publication and dissemination rights). This will ensure the widest possible protection and dissemination of information under copyright laws.Open Choice articles do not require transfer of copyright as the copyright remains with the author. In opting for open access, the author(s) agree to publish the article under the Creative CommonsAttribution License.OffprintsOffprints can be ordered by the corresponding author.Color illustrationsOnline publication of color illustrations is free of charge. For color in the print version, authors will be expected to make a contribution towards the extra costs.Proof readingThe purpose of the proof is to check for typesetting or conversion errors and the completeness and accuracy of the text, tables and figures. Substantial changes in content, e.g., new results, corrected values, title and authorship, are not allowed without the approval of the Editor.After online publication, further changes can only be made in the form of an Erratum, which will be hyperlinked to the article.Online FirstThe article will be published online after receipt of the corrected proofs. This is the official firstpublication citable with the DOI. After release of the printed version, the paper can also be cited by issue and page numbers.。
报道实验小学的课后活动英语作文
报道实验小学的课后活动英语作文全文共3篇示例,供读者参考篇1After-School Activities at Experimental Primary SchoolIntroductionExperimental Primary School offers a variety of after-school activities to enrich students' learning experiences and foster personal growth. These activities provide opportunities for students to explore their interests, develop new skills, and build relationships with their peers.Academic SupportMany students participate in academic support programs after school. These programs offer extra help with homework, test preparation, and skill development in subjects such as math, English, and science. Teachers and tutors work closely with students to identify their strengths and areas for improvement, providing personalized instruction and support.Extracurricular ActivitiesAside from academic support, Experimental Primary School also offers a wide range of extracurricular activities for students to engage in. These activities include sports teams, clubs, music ensembles, art classes, and more. Students have the opportunity to explore their interests and talents outside of the classroom, engaging in activities that promote creativity, teamwork, and leadership skills.Community ServiceExperimental Primary School encourages students to participate in community service activities to give back to their local community. Students volunteer at local organizations, participate in environmental clean-up projects, and organize fundraisers for charitable causes. These activities promote empathy, social responsibility, and civic engagement among students.Social and Emotional LearningIn addition to academic and extracurricular activities, Experimental Primary School also offers programs focused on social and emotional learning. These programs help students develop important skills such as self-awareness, empathy, and conflict resolution. Through activities such as mindfulness workshops, peer mediation training, and group therapy sessions,students learn to navigate their emotions and build positive relationships with others.ConclusionOverall, the after-school activities at Experimental Primary School play a crucial role in enriching students' learning experiences and promoting their personal growth. Whether through academic support, extracurricular activities, community service, or social and emotional learning programs, students have the opportunity to explore their interests, develop new skills, and build relationships with their peers. By participating in these activities, students at Experimental Primary School are able to become well-rounded individuals who are prepared to succeed in school and in life.篇2After-School Activities at Experimental Primary SchoolAt Experimental Primary School, we believe that education goes beyond the classroom. That's why we offer a variety of after-school activities to enhance our students' learning experiences and help them develop essential skills outside of the traditional curriculum.One of the most popular after-school activities at our school is the robotics club. In this club, students have the opportunity to design and build their own robots, learn about programming and engineering principles, and participate in robotics competitions. Not only do students gain valuable hands-on experience in STEM fields, but they also learn important teamwork and problem-solving skills.Another popular after-school activity is the art club, where students can explore their creativity through painting, drawing, and sculpture. This club provides a creative outlet for students to express themselves and develop their artistic abilities. Students also have the opportunity to showcase their work in art exhibitions and competitions, further boosting their confidence and passion for the arts.For students who are interested in sports, we offer a variety of athletic clubs, including soccer, basketball, and track and field. These clubs give students the chance to improve their physical fitness, learn about teamwork and sportsmanship, and compete in inter-school tournaments. Our school has a strong focus on promoting a healthy and active lifestyle, and these clubs play a crucial role in achieving that goal.In addition to these clubs, we also offer academic support programs for students who need extra help with their schoolwork. Our teachers provide individualized tutoring sessions to help students improve their grades and gain a better understanding of challenging subjects. These programs ensure that all students have the opportunity to succeed academically and reach their full potential.Overall, the after-school activities at Experimental Primary School are designed to enrich our students' education, foster their talents and interests, and help them develop important life skills. We are proud to offer a wide range of opportunities for our students to grow and thrive outside of the classroom, and we believe that these activities play a crucial role in shapingwell-rounded and successful individuals.篇3After-School Activities at Experimental Primary SchoolIntroductionAt Experimental Primary School, students have the opportunity to participate in a wide range of after-school activities. These activities not only provide students with a chance to explore their interests and hobbies but also help todevelop their social skills, teamwork abilities, and overallwell-being. In this article, we will explore some of theafter-school activities offered at Experimental Primary School and the benefits they provide to the students.Sports ActivitiesOne of the most popular after-school activities at Experimental Primary School is sports. Students have the opportunity to take part in various sports such as basketball, football, volleyball, and badminton. These activities help students to stay active, improve their physical fitness, and develop teamwork skills. Through participation in sports, students also learn the values of sportsmanship, fair play, and perseverance.Arts and CraftsAnother popular after-school activity at Experimental Primary School is arts and crafts. Students can unleash their creativity and imagination through activities such as painting, drawing, pottery, and origami. These activities not only allow students to express themselves but also help to improve their fine motor skills and attention to detail. Through arts and crafts, students learn to appreciate the beauty of creativity and the importance of self-expression.Music and DanceExperimental Primary School also offers music and dance classes as part of its after-school activities. Students can learn to play musical instruments such as the piano, guitar, violin, and drums. They can also participate in dance classes such as ballet, hip-hop, and traditional folk dances. These activities help students to develop their musical talents, rhythm, coordination, and confidence. Music and dance classes at Experimental Primary School provide students with a platform to showcase their talents and passion for the arts.Academic SupportIn addition to sports, arts, and music, Experimental Primary School also provides academic support programs as part of its after-school activities. Students who need extra help with their homework, assignments, or exam preparation can attend tutoring sessions with teachers. These sessions help students to improve their academic performance, build their confidence, and develop effective study habits. Through academic support programs, students at Experimental Primary School receive personalized attention and guidance to help them succeed academically.Community ServiceExperimental Primary School encourages students to give back to the community through volunteer work and community service projects. Students can participate in activities such as cleaning up the school grounds, visiting elderly homes, organizing charity events, and fundraising for local causes. Through community service, students learn the values of empathy, kindness, and social responsibility. They also develop a sense of belonging and connectedness to their community.ConclusionIn conclusion, after-school activities at Experimental Primary School play a crucial role in the holistic development of students. These activities provide students with opportunities to explore their interests, develop their talents, and build valuable skills. Whether it is through sports, arts, music, academic support, or community service, students at Experimental Primary School are encouraged to grow, learn, and excel beyond the classroom. Through after-school activities, students at Experimental Primary School develop into well-rounded individuals who are prepared to face the challenges of the future.。
ResearchProjectProposal的研究的项目的计划
Research Project Proposal (generic template)This is a modified (expanded) version of a template used in:Iphofen, R. (2009) Ethical decision making in social research. A practical guide, London: Palgrave Macmillan – pages 200-04.This template may be copied and used for any research or teaching project subject to quoting the source.This template is designed to assist researchers to put together a project proposal. A good proposal should address or provide information on each of the elements outlined below. The amount of detail required will vary according to the precise research topic and the overall aims of the project. Research proposals should be written clearly and in such a way that an intelligent layperson can understand the principles involved. Any complex issues or technical terminology should be clarified for the benefit of research governance and ethics reviewers. The project proposal must offer enough information to clarify the project aims and methods, but not too much unnecessary or repetitive material. The proposal should demonstrate that the researcher fully understands the issues associated with the use of the proposed methods. It should indicate any known difficulties associated with applying those methods in the proposed setting. This document can then be used to …cut and paste‟ from the relevant fields into any other formal review forms as required.Reviewers’ CriteriaIn writing a proposal researchers would do well to remember the criteria that governance and ethics reviewers will have in mind when reading the proposal. They will be assessing throughout whether the project is …do-able‟. In simpleterms they should be thinking: can it be done, does it need to be done, can this person/these people do it, and can it be done in the way they are proposing? The overarching ethical question, which will be considered throughout the proposal, is: can it be done without harm to any of the people involved? The ultimate justification for a project must be: will it tell ussometh ing new and/or useful that we didn‟t already know?It is essential that full consideration is given to research ethics and this should be consistently demonstrated throughout the research proposal. If submission to a research ethics committee (REC) is required it should be made clear which REC will be reviewing the proposal. But ethical considerations should be embedded in research design from the outset and clearly indicated when necessary throughout the project proposal. Ethical concerns are related to the principles and values to be upheld whilst research is being conducted. The proposal must show throughout how the researchers intend to protect the rights, dignity, safety and well being of all actual or potential research participants –that includes …research subjects‟ as well as the researchers themselves. [After completing this proposal, go through it again using the “Ethics Review Checklist” to ensure key items have been attended to.]Provide:…a succinct and c lear project title[full title, short title and/ project nickname or acronym];…a clear statement of the research issue under investigation which……specifies the “research question” or questions AND…if appropriate, clarifies any “testable hypotheses”.[a short initial statement that makes the focus of the research clear] …some justification of the need for research to be conducted on this topic[explain if the research will fill a gap or meet a need – it might add toknowledge, deliver productive outcomes or add value for policy and/orpractice];…some discussion of existing information on the topic[at this stage a brief outline of the current state of knowledge – furtherjustification of the need for this research and which will be expandedlater in the full protocol];…an explanation of any secondary research that can/should be conducted[a brief statement of desk research or systematic literature review thatmay be required];…a rationale for conducting primary research[why new primary research is required];…an explanation of why the research needs to be condu cted in the chosen setting(s)[in particular, why the proposed subjects and/or setting are needed forthis research].This section combines the need for clear lines of responsibility and accountability together with a quick reference source for all those involved in the project. It also clarifies who is doing what and whether they can demonstrate the competencies necessary to accomplishing the research goal.Provide:…the name and contact details of the Principal Investigator (PI);…the names and contact details of all researchassistants/collaborators/partners in the project;…a clear indication of the research roles of all those involved in the project [the tasks/role allocated to each named individual];…brief, targeted CVs for PI, supervisor(s) and any collaborating researchers and partners; an indication of all researchers‟ experience or extra training if required[CVs help indicate any …track record‟ o f relevant experience in the field;acknowledge any gaps in competence (especially for noviceresearchers) and how these will be met];…a clarification of any advice or consultation that has been undertaken on project design such as peer review of the methodology;…names of sponsor and/or supervisor(s)[this may be a formal requirement for research governance];…any statement relating to research subjects‟ (service users, staff, carers etc.) participation in the design of the project.[making clear their precise tasks/role]A full research protocol must be provided explaining how and why the research is to be conducted.The protocol should contain:Literature review…an adequate review of the existing literature or previous research…c larification of whether the proposed study replicates prior work AND/OR …duplicates work done elsewhere…AND/OR…contains an element of originality.Methodology…an outline of and a rationale for the research design or approach taken;…details of the resea rch method(s) to be employed and any combinations of techniques or methods (e.g. a social survey employing a self-completion questionnaire);…it should be clearly indicated that the issues associated with the use of the methods being advocated are fully understood;…any difficulties associated with the use of the method(s) proposed are addressed by the prospective researcher;…details for any research instruments/measuring devices to be employed (e.g. questionnaires - copies of which need to be appended to the proposal; pre-validated and reliability-tested instruments offer a degree of security for the value of the research to be conducted and its comparative potential); …details of any baseline and outcome measures that will be taken;Participants…full ex planation of data collection procedures which sets out in detail: …any sampling strategy,…an explanation and justification for the sample size if sampling of apopulation is to be conducted,…any calculable power and effect sizes if appropriate,…the r ationale for any purposive or theoretical sampling provided.…an explanation of how research subjects might be systematically excluded from participation/selection dependent on sampling strategy or considerations for minimising anticipated harm to them, their group and/or their community; …full explanation of the procedure for gathering/collecting data;…full explanation of procedures for anonymising data and/or the maintenance of confidentiality if this is proposed;Data Storage and Protection…full expl anation of the procedure for storing data and whether the data will be retained or archived for secondary analysis. If data is to be disposed of details must be given for how and when this will happen....an assurance that the proposed project is compliant with the Data Protection Act, and how that assurance can be guaranteed.…a full explanation of the data analysis procedures that will be employed. Such as:…if qualitative data analysis is to be employed – an outline of theprocedure for coding/categorising data and if and how any datareduction will take place;…if quantitative data analysis is to be employed, an outline of theprocedure for grouping, collating and statistically testing datarelationships – specifying the tests to be used;…an outline of the use of any computer assisted data analysis (e.g.SPSS; NVivo) and how and why such methods are to be applied.…some evidence of ability to anticipate any potential sources of bias that could compromise the rigour and/or the objectivity of the project. Some detail about how these problems might be addressed if they arise.…an assessment of any potential for harm to individuals, groups or society and how this might be addressed. The types of harm to be assessed might include: psychological, physical, social, economic and legal; and consideration must be given as to whether the harm accrues from participation or systematic exclusion from participation. Some indication of how anticipated harms might be addressed should be supplied – together with a procedure for handling any complaints.…an assessment of the potential …vulnerability‟ of members of the research population and how this might be addressed;Project Timetable…a clear outline of the project timetable noting key stages in the project such as:…anticipated start and completion dates;…period of desk research and literature reviewing;…any pilot work or feasibility study;…the sequencing of interventions, baseline, outcome and evaluationmeasures;…the period set aside for data analysis and production of reports;…any anticipated obstacles to completing on schedule.[Insert GANTT and/or PERT charts or, at least, a simple tabulatedtimetable with the above items included showing awareness of theanticipated time needed to accomplish the given tasks.]…an outline of the anticipated benefits of conducting the research. These could be benefits to research subjects/participants, clients, service users, staff, government (local and national), the research site, the researcher(s) and/or the research organisation.…an explanation of any grounds for generalising the research findings beyond the immediate research site, organisation or subject group/population category being studied – e.g. regionally, across the UK, and/or internationally;…an outline of all intended forms of dissemination for the research findings to include:…an internal research report for funders/commissioners;…a public report (target numbers and audience specified);…press release to local/national media;…an assessed research dissertation or thesis;…conference/seminar presentations (local/national/international);…a self-published research report;…scholarly/professional journals.…an outline of any anticipated limitations to the public availability o f the project‟s findings.…clarification if research subjects (services users, clients, staff, carers etc.) will be involved in dissemination/implementation of research findings in any way; if not an explanation of why their inclusion is not necessary and/orunjustified; or if they are to be involved a rationale for why this would be of benefit.…an outline of how the research findings might help deliver better services, products or offer some improved value for money;…some consideration of whether the research will be of direct benefit to the research site in which it is being conducted – in the form of:…helping develop local research skills;…contributing to the research infrastructure in the organisation;…providing a basis for further research an d development;…result in ways in which management and professionals can improveservice/product delivery.…a discussion of the feasibility of implementing any findings in the research site, local community, more generally or other services.…an outline of any risks to researcher(s), subjects, organisations or the project as a whole that can be anticipated;…details of any risks to any collaborating social services group from permitting the project to be conducted (this includes the governance reviewing committee!);…a completed risk assessment form (append a completed “Project Risk Assessment Matrix”);…a specification of the system for recording and reporting any serious adverse events;…a specification of the indemnity/ins urance provision secured against any non-negligent harm. (Copies of certificates should be appended.)…a specification of the means whereby subjects (clients, service users, staff, members of the public etc.) will be informed of the nature of the project and precisely how the study will be described to potential participants (such as in the form of information leaflets and/or information letters; orscheduled/scripted oral descriptions; copies of these should be appended to the proposal).…an outline of the protocol for obtaining participants‟ consent to gathering data and to any further archiving or secondary data analysis (such as consent forms; again copies should be appended).[Consent can be gained in a variety of ways depending upon research design – so it need not be in the form of a written, signed andwitnessed consent form if such a procedure is deemed threatening orintimidating to participants or inhibitive of a valid methodology.]…specification of how the participants will be given “time to think” about whether they wish to participate; and how, if they wish to discontinue participation, this will be facilitated.…an outline of the lines of responsibility involved in the co nduct of the research.[An indication of who is accountable to whom in the form of anorganisational chart would help.]…a clear specification of the project “deliverables” (e.g. points of data collection and analysis, interim reports, final written report) and dates when they are due[Must be consistent with and match the timetable included earlier.]…evidence of the support of appropriate managers or gatekeepers etc. in the research site;[written letters of permission should be appended to the proposal or some statement of when and how such permission will be sought]…if this is research counting toward an education qualification there should be evidence of HEI approval, processing through HEI‟s governance and ethics procedure, in the form of a letter of approval including supervisor(s) details and signature(s).…evidence of CRB checks if required for the project and/or researchers‟ registration with the Independent Safeguarding Authority (ISA).A full budget document should detail the anticipated full costs of conducting the research and who (organisation or person) is actually funding the project.…an indication of the itemised expenditure on such things as:…human resources…equipment…travel…subsistence…accommodation…computer hardware/software.…an indication of the time that will be spent on the project by researchers and collaborators;…an indication of the source(s) of funding for the project.While the use of the “Ethic s Review Checklist” helps in anticipating and declaring ethical risks, the full proposal should offer clear evidence for the following:How valid consent from participants to take part in the study will be obtained.How the interests of and particularly …vulnerable‟ participants will be protected – such as the old, young people (children under 18 years), asylum seekers, prisoners, ethnic minorities and those with a disability. In the case of such participants special arrangements may have to be made to ensure valid consent and this may entail the use of proxies and/or gatekeepers.The procedure to be adopted if someone discloses something about their own or others‟ criminal actions and/or provides information about unprofessional behaviour.The procedure to be adopted if an action is uncovered that has detrimental consequences for individuals, groups, organisations or society.Familiarity with ethical guidelines on research produced by the researchers‟ own relevant professional associations (e.g. Social Research Association, British Sociological Association, British Psychological Society, Social Policy Association, UK Evaluation Society and so on).The medical research ethics principles contained in the Declaration of Helsinki (updated 2008) contain recommendations of value to social research, so reference to their implementation within the proposal will strengthen evidence for researchers‟ awareness of ethical concerns. In similar vein the International Commission on Healthcare‟s Good Clinical Practice guidelines must be followed if performing a clinical trial. The principles contained in this document could be applied to all practice-oriented studies and may be of use to any study adopting an experimental design with experimental and control groups within the social care field as well as in health and may, consequently, be relevant to a range of research in social and behavioural science.。
忙于做一项实验英语作文
忙于做一项实验英语作文Title: A Journey Through Experimental Endeavors。
In the realm of scientific inquiry, experimentation stands as the cornerstone of discovery and innovation. Engaging in experiments not only broadens our understanding but also fuels the quest for knowledge. As I delve into the intricacies of experimental work, I find myself navigating a landscape where curiosity meets methodical investigation. Herein lies my journey through the realm of experimental science.Experimentation begins with a question, a spark of curiosity that ignites the scientific process. For me, the journey often commences with meticulous research and background study to frame the inquiry within its relevant context. Understanding the existing body of knowledge allows me to identify gaps and formulate hypotheses that serve as the guiding light in my experimental endeavors.Once the groundwork is laid, it is time to embark on the journey of designing the experiment. This phase requires careful planning and consideration of variables, controls, and methodologies. Every detail must be meticulously crafted to ensure the validity and reliability of the results. From selecting the appropriate experimental setup to determining the sampling techniques, each decision shapes the trajectory of the investigation.With the blueprint in hand, I step into the realm of data collection. This phase demands precision and attention to detail as I execute the experiment according to the predetermined protocols. Whether it involves conducting controlled trials in a laboratory setting or collecting field data amidst the natural elements, every observation holds significance in unraveling the mysteries of the phenomenon under scrutiny.As data accumulates, the real work of analysis begins. Here, I employ a variety of statistical methods and analytical tools to decipher the patterns hidden within the numbers. From graphical representations to mathematicalmodels, each technique offers unique insights into the underlying dynamics of the system under study. It is through this process of analysis that raw data transforms into meaningful knowledge, paving the way for new discoveries and insights.Yet, the journey does not end with analysis. The true test of any experiment lies in its ability to withstand scrutiny and replication. As such, I engage in rigorous peer review and validation processes to ensure the robustness and reproducibility of my findings. Constructive feedback and collaboration play a pivotal role in refining the experimental approach and advancing the collective understanding of the scientific community.Beyond the confines of the laboratory, I am constantly reminded of the broader implications of my work. Experimental science has the power to shape policies, drive technological advancements, and address pressing societal challenges. Whether it be in the fields of medicine, environmental science, or engineering, the fruits of experimentation have far-reaching consequences that extendbeyond the confines of academia.In conclusion, the journey of experimental science is one of perpetual exploration and discovery. It is a testament to the human spirit of inquiry and the relentless pursuit of knowledge. As I navigate the twists and turns of this journey, I am reminded of the words of Louis Pasteur, who famously said, "Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world." It is with this spirit of enlightenment that I embark on each new experiment, eager to uncover the mysteries that lie ahead.。
Proposal 要求
Research ProposalAGEDS 510Proposal ContentPlease use the “The Research Proposal” document that begins on the next page as a guide for what to include in your proposal. This document lists each section of a research proposal and identifies key considerations about each section. Your grade for the written portion of this assignment will be based upon how well you addressed the key points contained in this document.The maximum overall length of the proposal is 7 pages double spaced with a 12 point font and one inch margins. A reference list must be included but does not count against your page limit. The maximum acceptable length of chapter one is 3 pages, and the maximum acceptable length of chapter three is four pages. Chapter 2 is not required.SubmissionsTo enhance the quality of your proposal and to assist you in achieving an on time completion, the following peer review schedule has been established. You are expected to submit your proposal for review on schedule and to complete your duties as a reviewer for another author on schedule. Peer review forms are provided in Lesson 1 in WebCT. The instructor will provide feedback to all students at each scheduled peer review process.Post your drafts and final proposal to the appropriate discussion areas in WebCT by their respective deadlines. The proposal should be attached to your message as a Word or PDF file. In the subject line write “Your Name Chapter 1” etc. Name the attached file “Your Name Chapter 1.doc” etc.FOLLOW THESE NAMING INSTRUCTIONS! Peer reviewer assignments are explained in the respective discussion areas in WebCT.EvaluationThe grade for this assignment will be divided between the written research proposal (80%) and your participation (20%) in the peer review process. Regarding the peer review process, you will earn 5% for submitting the required materials on time and 15% for providing a thorough and substantive peer review. You will also be expected to participate in a review of selected final proposals. This review process will provide feedback to authors and will aid in determining a winner of the coveted most outstanding proposal award.The Research ProposalChapter 1 – IntroductionC1.1 Title•The title should reveal to one who understands research the:o Major variables and any relationship(s) among the variables being examined in the study.o Type of research (descriptive survey, causal-comparative or correlational, or experimental).o Target population (the group the researcher wants to study and also to whom he or she wishes the results to apply).•Avoid unnecessary words like: “a study of” or “an investigation of”.•Focus on the essence of the study so that the title may be as brief as possible while still communicating the necessary information.•The title should be clear, concise and descriptive enough to permit the study to be indexed in its proper category.C1.2 Background and Setting•Introduce the reader to the problem being investigated.•Set the problem within the proper context.•Base this section primarily on facts. You may include opinion.•Cite the source of all facts and opinions used in this section and include the sources in your reference list.•Use this section as the “lead in” to your problem statement.•Make sure that the arguments used to isolate the dimensions of your problem are logically sound.C1.3 Statement of the Problem•State the problem clearly and concisely.•Problem statements are often more easily identified and interpreted when they are written in the form of a question.•Restrict the scope of the problem statement.•Make sure that the problem is amenable to research. Avoid philosophical issues, as well as value or judgmental questions.•Make sure that the problem statement can be addressed ethically.•The problem statement should be consistent with the information presented in the background and setting section.• A solution to the problem should contribute to the knowledge base of the discipline. •Research aimed at addressing the problem should lead to ideas for future research.C1.4 Objectives of the Study•First write specific research questions, objectives, or hypotheses depending upon the type of research that you plan to conduct. Present them in list form.•Write an overall purpose statement that reflects all of you questions, objectives or hypotheses.This statement should appear just prior to the list of questions, objectives or hypotheses. •Research questions or objectives should be very specific and should identify variables that are being investigated.•Hypotheses should be written as directly testable relational statements.•Hypotheses may be directional or nondirectional depending on what would be consistent with the existing body of knowledge.•Null hypotheses are not stated in the proposal.C1.5 Significance of the StudyNote: This section is NOT a required component of the Research Proposal Assignment. •Explain why your study is important. Base this explanation on your problem statement and your intended approach to addressing it. Stay focused.•Consider the following questions in deciding what to include in this section:o How will theory be tested or further developed?o How will the knowledge base be expanded?o How will practical problems be solved?o Who might benefit from your study and how?o Will the study have application to professional practice?C1.6 Limitations/DelimitationsNote: This section is NOT a required component of the Research Proposal Assignment.You should provide a list of specifically stated limitations (weaknesses) that apply to your study. Examples of limitations include:o Small sample sizeso Errors in measuremento Failure to control extraneous variableso Control for extraneous variables, etc.•You should provide a list of specifically stated delimitations (boundaries that indicate what is being researched and what is not) that apply to your study. Examples of delimitations include: o Specific geographic boundarieso Grade level of students that are the subjects of your studyo Specific constructs that will be measuredC1.7 Definition of TermsNote: This section is NOT a required component of the Research Proposal Assignment.Analyze your research questions, objectives, and or hypotheses for words that should be defined. •Define all variables and important terms in clear and unequivocal language.•Present the definitions in list form.•Constitutive definitions should be provided for all important words. These are like dictionary definitions in that words are used to define the key terms.•Variables or characteristics that you plan to measure must be defined operationally.Operational definitions describe how variables will be measured and translate something theoretical into something observable.•Do not define generally understood concepts unless you are using them in a unique way. Chapter 2 – Review of LiteratureNote: This chapter is NOT a required component of the Research Proposal Assignment. •Write chapter 2 in sections based on your research questions, objectives, and/or hypotheses. •Use the review of literature to establish a theoretical framework for the study.•Do not abstract prior studies in chronological order and force the reader to assimilate the facts and draw conclusions!•Synthesize prior studies by weaving them into a network of relationships that point out relevant issues and reveal gaps in knowledge.•Comment on previous related studies and whether their samples were adequate, their techniques satisfactory, and their conclusions warranted. It should be clear that previous studies have not adequately addressed your research problem.Chapter 3 – MethodologyC3.1 Research Design•Identify the purpose and type (e.g. descriptive survey, correlational, causal comparative, quasi-experimental, experimental) of research that you will conduct. For example: “The purpose of this correlational study was to…”•Describe the research design that will be used.•Illustrate the research design when appropriate.•Discuss the internal validity strengths and weaknesses of the study.•Explain how extraneous variables will be controlled.•Discuss external validity strengths and weaknesses of the study.•Organize this section by research questions, objectives, and/or hypotheses if multiple designs will be used.C3.2 Subjects or Data Source•Describe your intended target population and indicate if there is a difference between the target population and the population that is accessible to you.•Explain how you will obtain a list (frame) of persons in the population and how you will minimize frame error (inaccuracies in the list).•Indicate whether you will study the entire population (a census) or if you will select a sample. •If a sample is used, justify and describe your sampling procedures. Provide a rationale (e.g.desired margin of error, limited resources) for the sample size.C3.3 Instrumentation•Describe carefully the procedures that will be used to ensure that all instruments are valid.Validity answers the following question: Does the instrument measure what it purports to measure with the population that will be used?•Describe carefully the procedures that will be used to ensure that all instruments are reliable.Reliability answers the following question: Does the instrument yield consistent results with subjects similar to those being studied?•Explain why the instruments are appropriate for your study. This is an indication of suitability. •If applicable, how will interviewers or observers be trained? How will inter and intra rater reliability be established?•How will incomplete data, obvious response set, lying, cheating, and unanswered items be dealt with?•Explain your plans for pilot and/or field testing your instruments.•Clearly explain how all variables are measured. It should be clear what level of measurement is represented by each variable. This is important information in determining the appropriate statistical analysis of the data.C3.4 Conditions of Testing•You may title this section “Data Collection”.•Explain how informed consent of subjects to participate in the study will be obtained. •Describe when, where, and under what conditions the data were gathered.•Describe the order in which instruments were administered.•Indicate whether time limits were set for completing some or all of the instruments. •Describe any oral and/or written directions that were given to the subjects.•Explain what will be done to reduce measurement error when instruments seek information that is sensitive and could lead to socially acceptable answers.•For survey research, describe in detail each contact with subjects. Also, indicate the time interval between each contact.•Explain how you will deal with nonresponse error.•Explain how you will calculate the response rate.•While the data is being collected keep a detailed record of any events that might impact the results. This could be very helpful to you in explaining your findings.C3.5 Treatments•Describe in detail all levels of the independent variable (s). Describe them well enough that another researcher could conduct the study in exactly the same way that you did (replication).This is very important!•If attribute (nonmanipulated) independent variables will be included in the analysis, identify them and describe each level of each variable in detail.C3.6 Data Analysis•You should select statistical techniques that fit the design and objectives of the study. You should never choose a statistical technique or research design then try to find a study that would use it.•Describe the analysis procedures and statistics that will be used for each question, objective and/or hypothesis.•Explain how data will be coded and entered. –Not Required for the Research Proposal Assignment•Explain how the data will be checked for errors and “cleaned up” after entry.–Not Required for the Research Proposal Assignment•Identify the software that will be used to collect, organize and analyze the data.•If inferential statistics will be used, specify the level of significance that will be used.Recommendations for Self Evaluation of the Written Proposal1•Write a draft of the proposal.•Put the draft away for a few days.•Read a paper copy of the draft.•Critically analyze the draft for organization and logical thought.•Make sure that your ideas are clearly communicated.•Sentences should be clear and concise.•Carefully select words.•Look for spelling, grammar, punctuation and typographical errors.•Ask yourself if the proposal still seems feasible.•Integrate your corrections into a second draft.•Obtain lots of feedback from others.1 Leedy, P. D., & Ormrod, J. E. (2005). Practical research: Planning and design (8th edition). Upper Saddle River, NJ: Pearson Education, Inc.。
统计学英汉词汇对照
L
Logistic回归模型 Logistic regression model
历史性对照研究 historical control trial
利弊比 likelihood of being helped vs harmed, LHH
循证医学、统计学英汉词汇对照
.
(仅供参考)
(以首字的汉语拼音为序)
A
安全性 Safety
B
半随机对照试验 quasi- randomized control trial,qRCT
背景问题 background questions
比值比 odds ratio,OR
随机对照临床试验 randomized clinical trials, RCT
随机对照试验 randomized control trial, RCT
随机化隐藏 randomization concealment
随机效应模型 random effect ቤተ መጻሕፍቲ ባይዱodel
T
特异度 specificity
H
灰色文献 grey literature
后效评价 reevaluation
获益 benefit
J
机会结 chance node
疾病谱偏倚 Spectrum bias
技术特性 Technical properties
加权均数差 weighted mean difference, WMD
临床证据手册 handbook of clinical evidence
零点 Zero time
灵活性 flexibility
behavior research methods分区 -回复
behavior research methods分区-回复Behavior Research MethodsBehavior research methods refer to the techniques and tools used by researchers to study and understand human behavior. These methods are essential in various fields, including psychology, sociology, anthropology, and education, among others. In this article, we will explore the different types of behavior research methods, their applications, and the step-by-step process involved in carrying out such research.Types of Behavior Research Methods:1. Experimental Methods: Experimental methods involve the manipulation of one or more variables to determine their effect on behavior. Researchers randomly assign participants to different conditions and measure their responses. This allows them to establish cause-and-effect relationships between variables. Examples of experimental methods include laboratory experiments, field experiments, and quasi-experiments.2. Observational Methods: Observational methods involve observing and documenting behavior in its natural setting withoutany intervention from the researcher. This method allows researchers to study behavior as it occurs naturally and understand the context in which it occurs. Examples of observational methods include naturalistic observation, participant observation, and structured observation.3. Survey Methods: Survey methods involve collecting data from a large sample of participants using questionnaires or interviews. This method allows researchers to gather information about people's attitudes, beliefs, and behaviors in a relatively short period. Surveys can be conducted through face-to-face interviews, phone interviews, mail, or online platforms.4. Case Study Methods: Case study methods involve in-depth and detailed analysis of an individual, group, or event. Researchers collect data from multiple sources, such as interviews, observations, documents, and archival records, to gain a comprehensive understanding of the subject. Case studies are often used when studying rare phenomena or when a deep understanding of a specific situation is needed.5. Correlational Methods: Correlational methods involve examiningthe relationship between two or more variables without manipulating them. Researchers measure the variables and determine the strength and direction of their relationship using statistical analysis. Correlational methods help identify associations and patterns, but they do not establish causality.Step-by-Step Process of Conducting Behavior Research:Step 1: Identify Research Question: The first step in conducting behavior research is to identify a research question or problem. This question should be specific and related to the behavior under investigation.Step 2: Literature Review: Conduct a thorough review of existing literature to understand what is already known about the topic. This helps in identifying gaps in knowledge and informs the research design.Step 3: Choose Research Method: Select the appropriate research method based on the research question, available resources, and ethical considerations.Step 4: Sample Selection: Determine the target population and use appropriate sampling techniques to select a representative sample. Ensure that participants' rights and confidentiality are protected.Step 5: Data Collection: Collect data using the chosen research method. This may involve administering surveys, conducting interviews or observations, or analyzing existing data.Step 6: Data Analysis: Analyze the collected data using appropriate statistical techniques. This can involve calculating means, correlations, conducting inferential analysis, or using qualitative methods to identify themes and patterns.Step 7: Interpretation of Results: Interpret the findings in the context of the research question and existing literature. Discuss the implications, limitations, and future directions for the field.Step 8: Report Writing: Prepare a comprehensive research report that includes an introduction, methodology, results, discussion, and conclusion sections. Follow ethical guidelines for reporting research findings.Step 9: Peer Review and Publication: Submit the research report to relevant journals or present the findings at conferences for peer review and possible publication.Step 10: Replication and Further Research: Encourage replication of the study to validate the findings and guide further research in the field.In conclusion, behavior research methods provide a systematic approach to studying human behavior. Researchers employ various methods such as experimental, observational, survey, case study, and correlational methods to gain insights into behavior. The step-by-step process involves identifying the research question, choosing the appropriate research method, collecting and analyzing data, and interpreting the results. Through these methods, researchers contribute to the advancement of knowledge in their respective fields and facilitate evidence-baseddecision-making in various domains.。
酶标仪(MicroplateReader)
酶标仪(Microplate Reader)Resolution spectrometermedical aircraftMicroplate enzyme immunoassay, is a special instrument for ELISA. Can be simply divided into semi-automatic and fully automatic 2 categories, but the working principle is basically consistent, is the core of a colorimeter, the colorimetric method was used to analyze the content of antigen or antibodies. Determination of the general requirements of the final volume ELISA of the test solution in 250u L, using photoelectric colorimeter to complete the test, so the enzyme used in the photoelectric colorimeter with special requirements.CatalogWorking principlestructureUse notes, work environmentOperation notesGuide for selection of enzyme marker and plate washing machineImmunoassayApplication scope and working principlestructureUse notes, work environmentOperation notesGuide for selection of enzyme marker and plate washing machine ImmunoassayApplication rangeEdit the work principle of this paragraphEliasa is actually a disguised form of special photoelectric colorimeter or spectrophotometer, the basic working principle and main structure and photoelectric colorimeter is basically the same. This is a single channel automatic sampling microplate working principle diagram. Light emitted through the light filter or monochromator into a beam monochromatic light, the samples were entered in the micro plastic. Monochromatic light was part of sample absorption, partly through the specimen irradiated by photoelectric detector, photoelectric detector of the samples were different and different light signals into electrical signals. The corresponding electrical signal via the preamplifier, logarithmic amplifier, analog-to-digital conversion and signal processing are sent into the processor for data processing and calculation, and finally by the display and printer to display results. Through the microprocessor control circuit to control the mechanical drive mechanism X Thedirection and direction of the Y move to move the microplate to achieve automatic sample inspection, while others are detected by hand moving microplate, thus eliminating the X, Y microplate readerThe direction of the mechanical drive mechanism and a control circuit, so as to make the instrument more compact, more simple structure. Micro plate is a transparent plastic plate in advance by embedding special placed samples, with small multi row of uniform size of the plate, hole are embedded with the corresponding antigen or antibody, microporous in each hole a few tenths of its common ml solution.Edit this paragraph structureThe specifications are 40 hole plate, 55 hole plate, 96 hole plate etc., orifice different instruments with different specifications, can be a hole a hole detection or rows for its detection. Eliasa with monochromatic light can be obtained by using the coherent filter, also available light the same monochromator photometer to get in. The filtering device using filter and colorimeter, filters can be put in the front plate, the back can be put on the plate, the effect is the same. The following figure is a commonly used microplate optical system. The light emitted by the lamp the light collecting mirror, mirror light bar after the arrival, as reflected by the reflector 90o vertical through colorimetric solution, and then through the filter to the photoelectric tube. From the eliasa diagram and diagram can be seen, and the ordinary photoelectric colorimeter has the following differences: (L) All tested than container color liquid is no longer used cuvette, but the useof plastic microtiter plate. Made of transparent polyethylene microporous plate commonly used materials, antigen antibody has stronger adsorption, so use it as solid carrier. (2) because of the plastic microtiter plate Sheng samples is a plurality of rows of holes, the only light through the vertical, eliasa so light is vertically through the test solution and the micro plate, the beam is from top to bottom, can also be from the bottom to the top through colorimetric solution. (3) were usually not only with A standard enzyme, sometimes the use of optical density to OD absorbance can be divided into single channel and multi-channel 2 types of microplate reader, single channel and automatic and manual 2 points. The instrument automatically type X, Y direction of the mechanical driving mechanism can be a small micro plate L in turn into the beam under test,Manual by manually moving the microtiter plate to be measured. Based on single channel microplate and multi-channel ELISA only, these enzymes are generally only standard automation type. It is not a light beam and a plurality of photodetectors, such as instrument of 12 channels with 12 or 12 beams a light source, a detector 12 and 12 amplifier, drive in the X direction of the machine under the action of 12 samples for a row is detected. The detection speed of multi-channel eliasa is fast, but its structure is more complex also higher prices. From the "Shaanxi medical examination" 1998.13 (4) of 12 in order to improve microplate detection results of indoor repeatability and enhance comparability among laboratories, the basic method of standard evaluation and identification instrument on the performance of the established enzyme are explained in detail and supplement, for peer reference and application inevaluation and identification instrument.Edit notes for use in this paragraphwork environmentThe enzyme spectrometer is a precise optical instrument, so a good working environment not only ensures its accuracy and stability, but also prolongs its service life. According to the DINVDE0871 Ordinance, the instrument shall be placed in the position of no magnetic field and disturbance voltage. On the basis of DIN4563519 regulations: the instrument should be placed in less than 40 dB in the environment. In order to delay the aging of optical components, direct sunlight should be avoided. Ambient temperature operation should be between 15 C and 40 DEG C, the humidity of the environment in 15%85% between. Operating voltage should be stable. Operating environment clean air, avoid water vapor, smoke and dust. Maintain dry, clean, level countertops and adequate operating space.Operation notesThe function of the microplate reader is to read the results of the enzyme-linked immunosorbent assay kit, so the use of the reagent kit must be standardized to obtain accurate results. Many hospitals in the use of enzyme mark instrument before, through the visual judgment of the results, the operation process is arbitrary, in the use of enzyme mark instrument, if not correct the operation habit in time, will cause greater error. In the operation of enzyme labeling instrument, the following items should be paid attention to: adding liquid andliquid, mixing liquid head can not be mixed. Wash the board and wash it well. If conditions permit, use plate washing machine to avoid cross contamination. In strict accordance with the instructions of the reagent box operation, the reaction time is accurate. In the measurement process, do not touch the microplate, squeeze operator to transfer the hand plate anti enzyme. Do not spill the sample or reagent onto the surface or inside of the instrument. Wash hands after the operation is completed. If the samples or reagents used are contaminated, toxic and biological hazards, please strictly follow the operating instructions of the kit to prevent damage to the operator. If the instrument has been contaminated or contaminated, clean and disinfect it. Do not turn off the power during the measurement. For the deviation of the measurement result caused by the reagent box, the parameters should be modified in time according to the actual conditions to achieve the best results. Use the hood for the rear lid. In case of technical failure, you should contact the manufacturer in time, and do not remove the enzyme marker without permission.Edit this section of enzyme marker and washing machine selection guideEnzyme labeling apparatus (MicroplateReader) is a professional instrument for reading and analyzing the results ofenzyme-linked immunosorbent assay (EIA). ELISA by coupling in antigen or antibody on the enzyme catalytic chromogenic substrate, the reaction results in the color display, the color depth of the absorbance size can determine the concentration of samples tested antibody or antigen. Widely used in clinical laboratory, biology, agricultural science, food andEnvironmental Sciences in the microplate reader, especially in recent years, due to the application of ELISA kit, the eliasa in reproductive health care in the field more and more widely, and promote the level of technology to improve reproductive health. At present, many domestic family planning station system to carry out the ELISA test items, such as: five items of hepatitis B, AIDS detection, eugenics series detection, hormone detection etc.. Most used visual methods in the past,There is a lack of scientific basis for the results reported. For example: a Toxoplasma detection kit, the critical value is defined as: negative control products od * 2.5, by visual inspection can not determine whether the color of the reaction samples hole exceeds the critical value. The color comparison between the two holes may be ok with the naked eye, but it is impossible to compare the color of one hole to 2.5 times the color of the other hole. A number of authoritative domestic institutions, such as the Ministry of health clinical inspection center and family planning system repeatedly stressed the importance of microplate, and enzyme-linked immunoassay reagent using microplate ELISA reagent interpretation, quality control should also be using a microplate reader, and provide the original data measured standard enzyme, and kit specification of the manufacturers is not made by visual observation. At the same time the project of ELISA is often some substantial infection and disease (such as hepatitis, AIDS, eugenics, etc.) more precise interpretation, the misdiagnosis of disputes difficult to deal with. In addition, the detection of EIA reagents such as hepatitis C and AIDS before operation is the necessary means to avoid medical disputes caused by blood transfusion, and isbeing adopted by many units.Edit this section of diagnostic methodsThe diagnosis in our country are mainly as follows: three (EIA) ELISA, radioimmunoassay (RIA) and light, following the situation in the market: the market recession cycle RIA ELISA growth stage light enters the RIA technology because of pollution of reagents and the validity of such problems are gradually eliminated in the the international and domestic markets, and chemiluminescence reagents and more expensive equipment, in the domestic popularity especially in the popularization of family planning system takes a long time, EIA reagent stability, reasonable price, supply charge, enzyme immunoassay in the growth stage in China market, so buy eliasa is suitable. In particular, it is urgent that the family planning and maternal and child health care system be equipped with enzyme markers in china. As early as a few years ago, the WHO had recommended routine screening of TORCH for pregnant women, but unfortunately, RCH testing has not been widely developed in China because of the lack of such devices as enzyme markers and plate washing machines. TORCH infection is referred to as TORCH syndrome in perinatal medicine. Because of the infection of pregnant women, fetuses and newborns, it has attracted great attention in the world of gynecology and obstetrics and pediatrics. Infection during pregnancy is not only harmful to the mother, but also can have a serious impact on the fetus and the newborn. Through the placenta can cause intrauterine infection and lead to miscarriage, premature birth, stillbirth or fetal growth retardation and deformity, through the birth canal and breast milk can cause neonatalinfection. Such as nervous system involvement can cause varying degrees of mental retardation and paralysis, deafness ORCH infection and eugenics has important relationship. Therefore, RCH (IgG and gM) examination is usually called eugenics check ten. At present, the detection methods of TORCH mainly include radioimmunoassay (RIA) and enzyme immunoassay (EIA). Since radioimmunoassay requires special instruments and radiation hazards, it is now being replaced by enzyme immunoassay (EIA). EIA method has the advantages of strong specificity, high sensitivity, simple, fast, low cost and so on. As long as equipped with enzyme markers and other relevant equipment, most general laboratories can be easily carried out. Obviously, as soon as possible in the planning system, popularity of enzyme markers and other equipment is an urgent need. The implementation of this work will help improve the level of diagnosis and treatment, reduce the incidence of maternal and child diseases, thereby improving the health of the entire nation. At present, more and more EIA kits available on the market such as: T3, T4, TSH, TORCH series, infertility series, cancer marker, typhoid fever and paratyphoid fever, other sexually transmitted diseases through MTCT (such as gonorrhea, syphilis, and hepatitis (HIV) such as HBV, HCV), and fetal antibody determination of TSH, newborn, vaccine reaction, the market also has complete EIA kit. The use of enzyme markers is conducive to expanding the testing items and improving the detection level, and the social and economic benefits are simultaneously developed. Enzyme linked immunosorbent assay (ELISA) is one of the labeling techniques,It is a sensitive, specific, fast and automated modern technique developed from fluorescent antibody technology andisotope immunoassay technologyEdit the scope of this paragraphThe name of the project referred to as hematology test classification of platelet antibody test, PAIgA PAIgG, PAIgM D- two dimer D-Dimer determination of serum fibrin degradation products by FDP three triiodothyronine, four triiodothyronine T4 immunological test determination of T3, C reactive protein determination of CRP determination of immunoglobulin IgD and IgE circulating immune complexes CIC determination of rheumatoid factor determination of IgG, IgA, IgM class RF anti thyroglobulin antibody, microsomal antibody determination of TG and TM tumor immunological detection of alpha fetoprotein AFP determination of carcinoembryonic antigen CEA determination of prostatic specific antigen determination of PSA pancreatic cancer, bile duct cancer, gastric cancer the determination of CA19-9 in ovarian cancer by CA125 in breast cancer by CA15-3 in cervical squamous cell carcinoma by SCC multiple myeloma determination Determination of adenocarcinoma of hTG, infectious diseases, immunological tests, detection of hepatitis A serology, anti HAV-IgM enzyme markersDetection of hepatitis B serological detection of HCV serological detection of two pairs of anti HAV-IgG and anti HDV HCV-IgM serological anti HDV-IgG and anti HDV-IgM serum anti HEV HEV-IgG hemorrhagic fever with renal syndrome antibody detection of Japanese encephalitis virus HFRS-IgG antibody detection of IgM human immune deficiency virus antibody (AIDS) detection of HIV beta 2 M eugenics the function of detectionof Toxoplasma gondii (body) detection of virus detection of rubella virus TOXO detection of cytomegalovirus RV detection of herpes simplex virus CMV anti HSV (I, II) the instrument can also do other genetic testing and drug residues, pesticide residue testing projects。
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The Peer Sampling Service: Experimental Evaluation of Unstructured Gossip-Based ImplementationsM´a rk Jelasity1,Rachid Guerraoui2,Anne-Marie Kermarrec3,and Maarten van Steen41University of Bologna,Italy,jelasity@cs.unibo.it,and RGAI,MTA SZTE,Szeged,Hungary2EPFL,Lausanne,Switzerland,Rachid.Guerraoui@epfl.ch3INRIA,Rennes,France,Anne-Marie.Kermarrec@irisa.fr4Vrije Universiteit,Amsterdam,The Netherlands,steen@cs.vu.nlAbstract.In recent years,the gossip-based communication model in large-scale distributed systems has become a general paradigm with im-portant applications which include information dissemination,aggrega-tion,overlay topology management and synchronization.At the heart of all of these protocols lies a fundamental distributed abstraction:the peer sampling service.In short,the aim of this service is to provide every node with peers to exchange information with.Analytical studies reveal a high reliability and efficiency of gossip-based protocols,under the(often im-plicit)assumption that the peers to send gossip messages to are selected uniformly at random from the set of all nodes.In practice—instead of requiring all nodes to know all the peer nodes so that a random sample could be drawn—a scalable and efficient way to implement the peer sam-pling service is by constructing and maintaining dynamic unstructured overlays through gossiping membership information itself.This paper presents a generic framework to implement reliable and ef-ficient peer sampling services.The framework generalizes existing ap-proaches and makes it easy to introduce new ones.We use this frame-work to explore and compare several implementations of our abstraction. Through extensive experimental analysis,we show that all of them lead to different peer sampling services none of which is uniformly random. This clearly renders traditional theoretical approaches invalid,when the underlying peer sampling service is based on a gossip-based scheme. Our observations also help explain important differences between design choices of peer sampling algorithms,and how these impact the reliability of the corresponding service.1IntroductionMotivation Gossip-based communication protocols have been applied success-fully in large scale systems.Apart from the well-known traditional application for information dissemination[6,9],gossiping has been applied for aggregation[16, 14,13],load balancing[15],network management[29],and synchronization[20]. The common property of these protocols is that,periodically,every node of the distributed system exchanges information with some of its peers.The underlying service that provides each node with a list of peers is a fundamental distributed component of gossip-based protocols.This service,which we call here the peer sampling service is usually assumed to be implemented in such a way that any given node can exchange information with peers that are selected following a uniform random sample of all nodes in the system.This assumption has led to rigorously establish many desirable features of gossip-based broadcast protocols like scalability,reliability,and efficiency(see,e.g.,[24]in the case of information dissemination,or[16,14]for aggregation).To achieve this uniform random selection,many implementors opt for the solution where every node knows all other nodes of the system[4,11,17].Prac-tically speaking,every node maintains a membership table,also called its view, the size of which grows with the size of the system.The cost of maintaining such tables has a non-negligible overhead in a dynamic system where processes join and leave at run time.In short,whereas the application and its underlying gossip-based protocol are supposed to be scalable,it is wrong to assume that this is also the case for the underlying peer sampling service.Recently,much research has been devoted to designing scalable implemen-tations of this service.The basic idea is to use a gossip-based dissemination of membership information naturally integrated into the service[8].The continu-ous gossiping of this information enables the building of unstructured overlay networks that capture the dynamic nature of distributed peer-to-peer systems and help provide very good connectivity in the presence of failures or peer dis-connections.Interestingly,there are many variants of the basic gossip-based membership dissemination idea,and these variants mainly differ in the way new views are built after merging and truncating views of communicating peers(see,e.g.,[12]). So far,however,there has never been any evaluation of and comparison between these variants,and this makes it hard for a programmer to choose the implemen-tation of the peer sampling service that best suits the application needs.More importantly,it is not clear whether any of these variants actually lead to uniform sampling,which,as we pointed out,lies at the heart of all analytical studies of gossip-based protocols.In search for an answer to these questions,this paper introduces a generic protocol scheme in which known and novel gossip-based implementations of the peer sampling service can be instantiated,and presents an extensive empirical comparison of these protocols.Contribution First,we identify a new abstract service,the peer sampling service, which is a fundamental building block underlying gossip-based protocols.Thispeer sampling service is thus indispensable for gossip-based implementations of a wide range of higher level functions,which include information dissemination, aggregation,network management and synchronization.Second,as a result of identifying this service and performing its logical sep-aration in a class of existing applications,we present a generic protocol scheme, which generalizes the gossip-based peer sampling service protocols we are aware of.Our scheme makes it possible to implement new protocols as well.Third,we describe an experimental methodology to evaluate the protocols in question.A key aspect of the methodology is that we focus on the overlay net-work that is induced by the peers that the service returns to nodes.In particular, we examine if these overlays exhibit stable properties,that is,whether the corre-sponding protocol instances lead to the convergence of important properties of the overlay.We also measure the extent to which these communication topolo-gies deviate from the desirable uniform random model mentioned earlier.We do so by looking at several static and dynamic properties:degree distribution, average path length and clustering coefficient.We also consider the reliability of the service by examining its self-healing capacity and robustness to failure.The behavior of the protocol instances we evaluate shows a rather wide vari-ation.A common characteristic,however,is that no instance leads to a uniform sampling,rendering traditional theoretical approaches invalid when these pro-tocols are applied as a sampling service.This result is surprising,as uniform randomness has long been generally assumed based only on(wrong)intuition. As a result of our work,all previous theoretical results about these protocols assuming randomness will have to be revised to properly describe the observed behavior.Roadmap In Section2we define the peer sampling service.Section3describes our generic protocol and the various dimensions according to which it can be instantiated.Section4presents our experimentation methodology.Sections5,6 and7discuss our results in different simulation scenarios.In Section8we in-terpret the result of the experiments.Related work is discussed in Section9. Finally,Section10concludes the paper.2Peer Sampling ServiceThe peer sampling service is interpreted over a set of nodes that form the domain of the gossip-based protocols that make use of the service.The same sampling service can be utilized by multiple gossip protocols simultaneously,provided they have a common target group.The task of the service is to provide a participating node of a gossiping application with a subset of peers from the group to send gossip messages to.The API of the peer sampling service is extremely simple consisting of only two methods:init and getPeer.While it would be technically straightforward to provide a framework for a multiple-application interface and architecture,for a better focus and simplicity of notations we assume that there is only one application.The specification of these methods is as follows.init()Initializes the service on a given node if this has not been done before.The actual initialization procedure is implementation dependent.getPeer()Returns a peer address if the group contains more than one node.The returned address is a sample drawn from the group.The specification of this sample(randomness,correlation in time and with other peers)is implementation dependent(one research goal of the present paper is exactly to give information about the behavior of this method in the case of a class of gossip-based implementations).Many times an application needs more than one peer.To maintain focus we define getPeer to return only one peer.Applications requiring more peers can call this method repeatedly.We note however that allowing getPeer to return more peers at the same time might allow for optimizations of the implementation of the service.Note that we do not define a stop method.The reason is to ease the burden on applications by propagating the responsibility of automatically removing non-active nodes to the service layer.The design of the service should take into account requirements with respect to the quality of peer sampling,as well as the costs involved for providing a certain quality.Based on the growing body of theoretical work cited above,the service should ideally always return a peer as the result of independent uniform random sam-pling.However,we note that although this quality criterion is useful to allow rigorous analysis,it is by no means the case that all gossiping applications ac-tually require uniform randomness.For example,some applications require only good mixing of random walks,which can also be established without demanding that peers are sampled uniformly.On the other hand,applications such as those that do aggregation do at least require that samples are not drawn from afixed, static subset of all possible nodes.These two examples illustrate that the costs of sampling may be reduced if near-uniformity is good enough for the application that makes use of the sampling service.In short,for an implementation of the service there is a trade-offbetween the required quality of sampling and the performance cost for attaining that quality.Uniform randomness can be conveniently treated as a baseline to compare protocols to,and in particular the quality of the sampling service.3Evaluation FrameworkTo study the impact on various parameters of gossip-based approaches to peer sampling,we define an evaluation framework.A wide range of protocolsfits into this framework and in particular the peer sampling components of the protocols Lpbcast[8]and Newscast[12]are specific instances of protocols within this framework.System model We consider a set of nodes connected in a network.A node has an address that is needed for sending a message to that node.Each node maintainsdo foreverwait(T time units)p←selectPeer()if push then//0is the initial hop countmyDescriptor←(myAddress,0)buffer←merge(view,{myDescriptor})send buffer to pelse//empty view to trigger responsesend{}to pif pull thenreceive view p from pview p←increaseHopCount(view p)buffer←merge(view p,view)view←selectView(buffer)(a)active thread do forever(p,view p)←waitMessage()view p←increaseHopCount(view p)if pull then//0is the initial hop countmyDescriptor←(myAddress,0)buffer←merge(view,{myDescriptor})send buffer to pbuffer←merge(view p,view)view←selectView(buffer)(b)passive threadFig.1.The skeleton of a gossip-based implementation of a peer sampling service. addresses by means of a partial view,which is a set of c node descriptors.The value of c is the same for all nodes.Besides an address,a node descriptor also contains a hop count,as we explain below.We assume that each node executes the same protocol,of which the skeleton is shown in Figure1.The protocol consists of two threads:an active thread initiating communication with other nodes,and a passive thread waiting for incoming messages.The skeleton code is parameterized with two Booleans(push and pull),and two function placeholders(selectPeer()and selectView()).A view is organized as a list with at most one descriptor per node and ordered according to increasing hop count.We can thus meaningfully refer to thefirst or last k elements of a particular view(note however that all hop counts do not necessarily differ so thefirst and last k elements are not always uniquely defined by the ordering).A call to increaseHopCount(view)increments the hop count of every element in view.A call to merge(view1,view2)returns the union of view1 and view2,ordered again by hop count.When there is a descriptor for the same node in each view,only the one with the lowest hop count is inserted into the merged view;the other is discarded.This design space enables us to evaluate in a simple and rigorous way the impact of the various parameters involved in gossip-based protocols along three dimensions:(i)Peer selection;(ii)View propagation;(iii)View selection.Many variations exist along each of these dimensions;we limit our study to the three most relevant strategies per dimension.We shall now define these dimensions.Peer selection Periodically,each node selects a peer to exchange membership information with.This selection is implemented by the function selectPeer()that returns the address of a live node as found in the caller’s current view.In this study,we consider the following peer selection policies:randheadtailThe node sends its view to the selected peerThe node requests the view from the selected peerThe node and selected peer exchange their respective viewsView selection Once membership information has been exchanged between peers and merged as explained above,peers may need to truncate their views in order to adhere to the c items limit imposed as a protocol parameter.The function selectView(view)selects a subset of at most c elements from view.Again,we consider only three out of the many possible view selection policies:randheadtail4Experimental methodologyAs already mentioned in Section2the baseline of our evaluation will be the ideal independent uniform random implementation of the sampling service.It is far from trivial to compare a given sampling service to this ideal case in a meaningful way.Statistical tests for randomness and independence tend to hide the most important structural properties of the system as a whole.Instead of a statistical approach,in our methodology,we switch to a graph theoretical framework,which provides richer possibilities of interpretation from the point of view of reliability,robustness and application requirements,as Section4.2also illustrates.To translate the problem into a graph theoretical language,we consider the communication topology or overlay topology defined by the set of nodes and their views(recall that getPeer()returns samples from the view).In this framework the directed edges of the communication graph are defined as follows.If node a stores the descriptor of node b in its view then there is a directed edge(a,b) from a to b.In the language of graphs,the question is how similar this overlay topology is to a random graph in which the descriptors in each view represent a uniform independent random sample of the whole node set?4.1Targeted questionsThere are two general questions we seek to answer.Thefirst and most fundamen-tal question is whether,for a particular protocol implementation,the communi-cation graph has some stable properties,which it maintains during the execution of the protocol.In other words,we are interested in the convergence behavior of the protocols.We can expect several sorts of dynamics which include chaotic be-havior,oscillations or convergence.In case of convergence the resulting state may or may not depend on the initial configuration of the system.In the case of over-lay networks we prefer to have convergence toward a state that is independent of the initial configuration.Sometimes this property is called self-organization. In our case it is essential that in a wide range of scenarios the system should automatically produce consistent and predictable behavior.Related is the question is that if there is convergence then what kind of communication graph does the protocol converge to?In particular,as mentioned earlier,we are interested in what sense do these graphs deviate from certain random graph models.4.2Selected graph propertiesIn order tofind answers to the above problems we need to select a set of observ-able properties that characterize the communication graph.In the following,we will focus on the undirected version of the communication graph which we get by simply dropping the orientation of the edges.The reason for this choice is that even if the“knows-about”relation that defines the directed communicationgraph is one-way,the actual informationflow from the point of view of the appli-cations of the overlay is potentially two-way,since after initiating a connection the passive party will learn about the active party as well.Now let us turn to the properties we will examine.Degree distribution The degree of a node is defined as the number of its neigh-bors in the undirected communication graph.We will consider several aspects of the degree distribution including average degree,the dynamics of the de-gree of a node,and the exact degree distribution.The motivation for looking at degree distribution is threefold and includes its direct relationship with reliabil-ity to different patterns of node failures[2],its crucial effect on the exact way epidemics are spread(and therefore on the way epidemic-based broadcasting is performed)[23]andfinally its key role in determining if there are communication hot spots in the overlay.Average path length The shortest path length between node a and b is the minimal number of edges that are necessary to traverse in the graph in order to reach b from a.The average path length is the average of shortest path lengths over all pairs of nodes in the graph.The motivation of looking at this property is that,in any information dissemination scenario,the shortest path length defines a lower bound on the time and costs of reaching a peer.For scalability,small average path length is essential.Clustering coefficient The clustering coefficient of a node a is defined as the num-ber of edges between the neighbors of a divided by the number of all possible edges between those neighbors.Intuitively,this coefficient indicates the extent to which the neighbors of a are also neighbors of each other.The clustering co-efficient of the graph is the average of the clustering coefficients of the nodes, and always lies between0and1.For a complete graph,it is1,for a tree it is0. The motivation for analyzing this property is that a high clustering coefficient has potentially damaging effect on both information dissemination(by increas-ing the number of redundant messages)and also on the self-healing capacity by weakening the connection of a cluster to the rest of the graph thereby increasing the probability of partitioning.Furthermore,it provides an interesting possibil-ity to draw parallels with research on complex networks where clustering is an important research topic(e.g.,in social networks)[30].4.3Parameter settingsThe main goal of this paper is to explore the different design choices in the protocol space described in Section3.That is,the parameters which we want to explore are peer selection,view selection,and symmetry model.Accordingly,we chose tofix the network size to N=104and the maximal view size to c=30.During our preliminary experiments some parameter settings turned out not to result in meaningful overlay management protocols.In particular,(head,∗,∗) results in severe clustering,(∗,tail,∗)cannot handle dynamism(joining nodes)protocol average numberruns cluster100%4112.09 (rand,rand,push) 2.27100%7150.52 (tail,rand,push) 2.000.01 0.1 150 100 150 200 250 300cycles (a)clustering coefficient 0 1020304050600 50 100 150200 250 300cycles (b)average node degree 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 50 100 150 200 250 300cycles (rand,rand,push)(tail,rand,push)(rand,rand,pushpull)(tail,rand,pushpull)(rand,head,pushpull)(tail,head,pushpull)(c)average path length Fig.2.Dynamics of graph properties in the growing scenario.Horizontal line indicates the property in a uniform random topology,vertical line indicates end of growthinstability in this scenario with respect to connectivity of the overlay (see Ta-ble 1).A non partitioned run of both (rand,rand,push)and (tail,rand,push)is included however.The partitioning of the push version of the protocols is due to the fact that it is only the first,central node that can distribute new links to all new members.For the same reason convergence is extremely slow when push is applied,while the pushpull versions do show fast convergence.Protocols (∗,rand,pushpull)are seemingly closer to the random topology,however,we will see that this is mislead-ing and is a result of a highly non-balanced degree distribution (see Section 6).5.2Ring lattice initial topologyIn this scenario,the initial topology of the overlay was a ring lattice,a structured topology.The motivation behind this experiment is to examine if the overlay properties converge to the same random structure with a low average path length even if the initial topology is highly structured and has a large average path length.We build the ring lattice as follows.The nodes are first connected into a ring in which each node has a descriptor in its view that belongs to its two neighbors in the ring.Subsequently,for each node,we add additional descriptors of the nearest nodes in the ring until the view is filled.Figure 3shows the output of this scenario as well.As in the case of the growing scenario,300cycles were run but here only 100are shown to focus on the more interesting initial dynamics of the protocols.We can observe that all versions result in quick convergence which is particularly well illustrated by path length in Figure 3(a)(note the logarithmic scale),but also by the other observed properties.10100 0 20 40 6080 100cycles (rand,rand,push)(tail,rand,push)(rand,rand,pushpull)(tail,rand,pushpull)(rand,head,push)(tail,head,push)(rand,head,pushpull)(tail,head,pushpull)(a)lattice,average path length 2.6 2.652.72.752.82.85 2.9 0 20 40 60 80 100cycles (b)random,average path length 0.01 0.1 1 0 20 40 6080 100cycles (c)lattice,clustering coefficient0.010.110 20 40 60 80 100cycles (d)random,clustering coefficient 52 53545556575859600 20 4060 80 100cycles (e)lattice,average node degree 52 53 54 55 56 57 58 59 60 0 20 40 60 80 100cycles (f)random,average node degreeFig.3.Dynamics of graph properties.Horizontal line shows uniform random topology.5.3Random initial topologyIn this scenario the initial topology was defined by a random graph,in which the views of the nodes were initialized by a uniform random sample of the peer nodes.Figure3includes the output of this scenario as well.As in the other scenarios,300cycles were run but only100are shown.The most interesting feature we can notice is that independently of starting conditions,all properties converge to the same value.This cannot be seen in the case of path length,but it is also true.We can also see that the values are rather close to that of the random topology,maybe with the exception of the clustering coefficient.However,to put these results in the appropriate context,we need to consider the degree distribution as well.For instance,the star topology—which has a maximally unbalanced degree distribution—also has a low diameter and low clustering coefficient,while it is obviously far from random.6Degree distributionWhen describing degree distribution in a dynamic system one has to focus on two aspects:the dynamics of the degree of individual nodes and the dynamics of the degree distribution over the whole overlay.In principle,knowing one of these aspects will not determine the other,and both are important properties of an overlay.The results presented in this section were obtained from the experiments performed according to the random initialization scenario described above.The evolution of the degree distribution over the whole overlay is shown in Figure4. We can observe how the distribution reaches itsfinal shape starting from the ran-dom topology,as the distributions that correspond to exponentially increasing time intervals(cycle0,3,30and300)are also shown.This time the behavior of the protocols can clearly be divided into two groups according to view selection.Note that previous experiments did not reveal this difference.Random view selection results in an unbalanced distribution and slow convergence while head selection is more balanced and very fast.This is a very important difference and it will be reflected in most of the following experiments as well.Let us continue with the question whether the distribution of the degree of a fixed node over time is the same as the distribution of the converged overlay at afixed cycle.In the overlay the degree of50nodes were traced during K=300 cycles.Table2shows statistical data concerning degree distribution over time at the50fixed nodes and over the full overlay in the last cycle(i.e.in cycle K).The notations used are as follows.Let d(i,j)denote the degree of node i in cycle j.Letd= 50i=1d i−d is the average andσis the empirical variance of the time-averages of the degree of the traced50nodes. Finally,(a)(rand,rand, push)(b)(rand,rand,pushpull)(c)(rand,head,push)(d)(rand,head,pushpull)(e)(tail,rand, push)(f)(tail,rand,pushpull)(g)(tail,head,push)(h)(tail,head,pushpull)Fig.4.Degree distributions on the log-log scale,when starting from a random topology. The ranges are[30,300]for the degree axis(horizontal),and[1:1000]for the frequency axis(vertical).Note that degree is guaranteed to be at least30.The symbol+denotes the random graph(cycle0).Empty box,empty triangle andfilled circle belong to cycle 3,30and300,respectively.are no emerging higher degree nodes on the long run.On the other hand,we again observe a major distinction according to view selection.In the case of random selection the oscillation has a much higher amplitude,the network is less stable.The last question we consider is whether the sequence of node degrees during the cycles of the protocol can be considered a random sequence drawn from the overall degree distribution.If not,then how quickly does it change,and is it per-haps periodical?To this end we present autocorrelation data of the degree time-series offixed nodes in Figure5.The band indicates a99%confidence interval assuming the data is random.The autocorrelation of the series d(i,1),...d(i,K) for a given time lag k is defined asr k= K−kj=1(d(i,j)−d i)d i)2,which expresses the correlation of pairs of degree values separated by k cycles.protocold √(rand,head,push)52.62352.703 1.394(tail,head,push)54.78555.519 2.690(rand,head,pushpull)52.71752.933 1.756(tail,head,pushpull)53.91653.888 2.176(rand,rand,push)58.40460.80419.062(tail,rand,push)58.84458.74617.287(rand,rand,pushpull)59.56961.30613.886(tail,rand,pushpull)59.66658.6169.756Table 2.Statistics describing the dynamics of the degree of individual nodes.-0.4-0.20.20.4 0.6 0.810 20 40 60 80100 120 140a u t o c o r r e l a t i o n lag (rand,rand,push)(rand,rand,pushpull)(rand,head,push)(rand,head,pushpull)Fig.5.Autocorrelation of the degree of a fixed random node as a function of time lag,measured in cycles,computed from a 300cycle sample.Protocols (tail,∗,∗)are omitted for clarity.For the correct interpretation of the figure observe that (rand,head,pushpull)can be considered practically random according to the 99%confidence band,while the time series produced by (rand,head,push)shows some weak high fre-quency periodic behavior.The protocols (∗,rand,∗)appear to show low frequency periodic behavior with strong short-term correlation,although to confirm that further experiments are necessary.This means that apart from having a higher oscillation amplitude,random view selection also results in a much slower oscil-lation.7Self-healing capacityAs in the case of the degree distribution,the response of the protocols to a massive failure has a static and a dynamic aspect.In the static setting we are interested in the self-healing capacity of the converged overlays to a (potentially massive)node failure,as a function of the number of failing nodes.Removing a large number of nodes will inevitably cause some serious structural changes in。