DMAT_749234-11-5_DataSheet_MedChemExpress
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Product Name:
DMAT CAS No.:
749234-11-5Cat. No.:
HY-15535Product Data Sheet
MWt:
476.79Formula:
C9H7Br4N3Purity :>98%
Solubility:
DMSO
Mechanisms:
Biological Activity:
DMAT is a potent and specific CK2inhibitor with an IC50of 013uM Pathways:Cell Cycle/DNA Damage; Target:CK2
DMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM. IC50 value: 0.13 uM. DMAT also displays submicromolar IC50 values with almost all of the other
kinases with special reference to PKD1, PIM3 and PIM1[3].
Target: CK2Protein kinase CK2 is involved in cell proliferation and survival, and found overexpressed in virtually all types of human cancer, including breast cancer. We demonstrate that inhibition of CK2 with 2-dimethylamino-4,5,6,7-tetrabromo-benzimidazole (DMAT), a potent and specific CK2 inhibitor,results in caspase-mediated killing of human breast cancer cells with acquired resistance to
antiestrogens [1].
References:
[1]. Yde CW, Frogne T, Lykkesfeldt AE, Induction of cell death in antiestrogen resistant human
breast cancer cells by the protein kinase CK2 inhibitorDMAT. Cancer Lett. 2007 Oct 28;256(2):229-37. g []In vitro:. Treatment with DMAT decreases the secretion of aldosterone, dehydroepiandrosterone sulfate, and androstendione in H295R human adrenocortical cancer cell line and results in an accumulation of 17-OH-progesterone. Cell growth as ...
[2]. Lawnicka H, Kowalewicz-Kulbat M, Sicinska P, Anti-neoplastic effect of protein kinase CK2inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010
May;340(2):371-9.[3]. Pagano MA, Bain J, Kazimierczuk Z, The selectivity of inhibitors of protein kinase CK2: an
update. Biochem J. 2008 Nov 1;415(3):353-65.[4]. Sass G, Klinger N, Sirma H, Inhibition of experimental HCC growth in mice by use of the kinase
inhibitor DMAT. Int J Oncol. 2011 Aug;39(2):433-42.Caution: Not fully tested. For research purposes only
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