MATERIALS AND METHODS FOR SENSITIZING MULTIDRUG RE
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专利名称：MATERIALS AND METHODS FOR
SENSITIZING MULTIDRUG RESISTANT CELLS 发明人：Jian-Ting Zhang,Jing Qi,Hui Peng,Zizheng
Dong
申请号：US13125530
申请日：20091024
公开号：US20110301108A1
公开日：
20111208
专利内容由知识产权出版社提供
摘要：Disclosed herein are materials and methods for sensitizing multidrug resistant cancer cells that express ABCG2 and related proteins members of a family of ATP-binding transporter superfamily that mediate drug efflux found in some types of multidrug resistant caner cells. A series of compounds, including (N-(4-chlorophenyl)-2-[(6-{[4,6-di(4-morpholinyl)-1,3,5-tri-azin-2-yl]amino}-1,3-benzothiazol-2-
yl)sulfanyl]acetamide), specifically inhibits ABCG2 and can be used to boost the bio-avail-ability of one or more effective cancer killing drugs, making it possible to use certain widely used chemotherapeutic reagent to treat multidrug resistance cancers. Using these compounds in combination with chemotherapeutic drugs that are substrates for ABCG2 and related proteins may also find utility in treating cancer cells that are not currently identified as multi-drug resistant Additionally, these compounds appear to accelerate the intercellular degradation of ABCG2 and related proteins. They are not toxic to animals at levels at which they effect the activity of ABCG2 expressed in multi-drug resistant cancer lines.
申请人：Jian-Ting Zhang,Jing Qi,Hui Peng,Zizheng Dong
地址：Carmel IN US,Carmel IN US,Beijin CN,Carmel IN US 国籍：US,US,CN,US
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