LY2811376_1194044-20-6_MSDS_MedChemExpress
Naglazyme(galsulfase)(抗生物)商品说明书
Naglazyme® (galsulfase)(Intravenous)Document Number: MH-0084 Last Review Date: 02/01/2022Date of Origin: 11/28/2011Dates Reviewed: 12/2011, 02/2013, 02/2014, 12/2014, 10/2015, 10/2016, 10/2017, 10/2018, 02/2019,02/2020, 02/2021, 02/2022I.Length of AuthorizationCoverage will be provided for 12 months and may be renewed.II.Dosing LimitsA.Quantity Limit (max daily dose) [NDC Unit]:•Naglazyme 5 mg vial: 23 vials per 7 daysB.Max Units (per dose and over time) [HCPCS Unit]:•115 billable units every 7 daysIII.Initial Approval Criteria 1Coverage is provided in the following conditions:•Patient is at least 5 years of age; AND•Documented baseline 12-minute walk test (12-MWT), 3-minute stair climb test (3-MSCT), and/or pulmonary function tests (e.g., FEV1, etc.); AND•Documented baseline value for urinary glycosaminoglycan (uGAG); ANDMucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome) † Ф1,4,5•Patient has a definitive diagnosis of MPS VI as confirmed by the following:o Detection of pathogenic mutations in the ARSB gene by molecular genetic testing; ORo Arylsulfatase B (ASB) enzyme activity of <10% of the lower limit of normal in cultured fibroblasts or isolated leukocytes; AND▪Patient has normal enzyme activity of a different sulfatase (excluding patients with Multiple Sulfatase Deficiency [MSD]); AND▪Patient has an elevated urinary glycosaminoglycan (uGAG) level (i.e. dermatan sulfate or chondroitin sulfate) defined as being above the upper limit of normal bythe reference laboratory†FDA-approved indication(s); ‡Compendia recommended indication(s); ФOrphan DrugIV.Renewal Criteria 1,4,5Coverage can be renewed based on the following criteria:•Patient continues to meet indication-specific relevant criteria such as concomitant therapy requirements (not including prerequisite therapy), performance status, etc. identified insection III; AND•Absence of unacceptable toxicity from the drug. Examples of unacceptable toxicity include: anaphylaxis and hypersensitivity reactions, immune-mediated reactions, acute respiratorycomplications associated with administration, acute cardiorespiratory failure, severeinfusion reactions, spinal or cervical cord compression, etc.; AND•Disease response with treatment as defined by improvement or stability from pre-treatment baseline by the following:o Reduction in uGAG levels; AND▪Improvement in or stability of 12-minute walk test compared (12-MWT); OR▪Improvement in or stability of 3-minute stair climb test (3-MSCT); OR▪Improvement in or stability of pulmonary function testing (e.g., FEV1, etc.)V.Dosage/Administration 1Indication DoseMucopolysaccharidosis VI(MPS VI, Maroteaux-Lamy Syndrome) 1 mg/kg administered as an intravenous (IV) infusion oncea weekVI.Billing Code/Availability InformationHCPCS Code:•J1458 – Injection, galsulfase, 1 mg; 1 billable unit = 1 mgNDC:•Naglazyme 5 mg per 5 mL solution; single-use vial: 68135-0020-xxVII.References1.Naglazyme [package insert]. Novato, CA; BioMarin Pharmaceutical Inc.; December 2019.Accessed January 2022.2.Giugliani R, Harmatz P, Wraith JE. Management guidelines for mucopolysaccharidosis VI.Pediatrics. 2007 Aug;120(2):405-18.3.Giugliani R, Federhen A, Rojas MV, et al. Mucopolysaccharidosis I, II, and VI: Brief reviewand guidelines for treatment. Genet Mol Biol. 2010 Oct;33(4):589-604. Epub 2010 Dec 1.4.Vairo F, Federhen A, Baldo G, et al. Diagnostic and treatment strategies inmucopolysaccharidosis VI. Appl Clin Genet. 2015 Oct 30;8:245-55.5.Valaannopoulos V, Nicely H, Harmatz P, et al. Mucopolysaccharidosis VI. Orphanet J RareDis. 2010; 5: 5.6.Harmatz P, Giugliani R, Schwartz I, et al. Enzyme replacement therapy formucopolysaccharidosis VI: a phase 3, randomized, double-blind, placebo-controlled,multinational study of recombinant human N-acetylgalactosamine 4-sulfatase(recombinant human arylsulfatase B or rhASB) and follow-on, open-label extension study. JPediatr. 2006 Apr;148(4):533-539.Appendix 1 – Covered Diagnosis CodesICD-10 ICD-10 DescriptionE76.29 Other mucopolysaccharidosesAppendix 2 – Centers for Medicare and Medicaid Services (CMS)Medicare coverage for outpatient (Part B) drugs is outlined in the Medicare Benefit Policy Manual (Pub. 100-2), Chapter 15, §50 Drugs and Biologicals. In addition, National CoverageDetermination (NCD), Local Coverage Determinations (LCDs), and Local Coverage Articles (LCAs) may exist and compliance with these policies is required where applicable. They can be found at: https:///medicare-coverage-database/search.aspx. Additional indications may be covered at the discretion of the health plan.Medicare Part B Covered Diagnosis Codes (applicable to existing NCD/LCD/LCA): N/AMedicare Part B Administrative Contractor (MAC) JurisdictionsJurisdiction Applicable State/US Territory ContractorE (1) CA, HI, NV, AS, GU, CNMI Noridian Healthcare Solutions, LLCF (2 & 3) AK, WA, OR, ID, ND, SD, MT, WY, UT, AZ Noridian Healthcare Solutions, LLC5 KS, NE, IA, MO Wisconsin Physicians Service Insurance Corp (WPS)6 MN, WI, IL National Government Services, Inc. (NGS)H (4 & 7) LA, AR, MS, TX, OK, CO, NM Novitas Solutions, Inc.8 MI, IN Wisconsin Physicians Service Insurance Corp (WPS) N (9) FL, PR, VI First Coast Service Options, Inc.J (10) TN, GA, AL Palmetto GBA, LLCM (11) NC, SC, WV, VA (excluding below) Palmetto GBA, LLCNovitas Solutions, Inc.L (12) DE, MD, PA, NJ, DC (includes Arlington &Fairfax counties and the city of Alexandria in VA)K (13 & 14) NY, CT, MA, RI, VT, ME, NH National Government Services, Inc. (NGS)15 KY, OH CGS Administrators, LLC。
烟酰胺-MSDS-中文
九、物理和化学性质
外观与性状:白色粉末8.0~131.0
相对密度:0.5~0.7g/cm3
沸点(℃):224.0℃
饱和蒸汽压(kPa):
燃烧热(kJ/mol):
临界温度(℃):
临界压力(MPa):
闪点(℃):182℃
爆炸上限%(V/V):
沸点(℃):
爆炸下限%(V/V):
七、安全操作和储存 操作注意事项:操作过程应佩戴防尘面罩;操作结束后立即洗手,避免皮肤、眼睛、衣服接触,工作场 所应有充足通风,避免粉尘产品。 避免接触皮肤和眼睛;穿戴个人防护用具如第八项规定;操作完成以后,立即对全身清洗。 储存注意事项:密封保存在阴凉、干燥和良好通风处;避免光线、热源和潮湿的影响并与其它化学物品 分储。
五、消防措施 危害特性:燃烧物有毒。 燃烧以后产生的有毒有害物质:主要是CO、CO2和NOx等。 适用灭火剂:所有灭火装置均可使用,水、化学干粉、二氧化碳等。 灭火人员的防护措施:灭火防护衣、自动呼吸机等。
六、泄露处理方法 个人注意事项:依据具体环境穿戴防护设施。 环境注意事项:物料漏出时避免粉尘产生,把泄漏物清扫进合适容器回收或处理,避免进入到下水道。 清理方法:工作人员需要穿戴合适的个人防护用品如第八项规定。收集散落的物料,保持容器良好密封 性,依据物料实际情况回收利用或者按照当地法规要求送到有资质的垃圾处理厂处理。
烟酰胺安全资料
一、产品与制造商资料 产品名称:维生素—烟酰胺(Niacinamide) 制造商名称:兄弟科技股份有限公司 地址:浙江省海宁市周王庙镇工业区 电话:0086-573-87015331 传真:0086-573-87015333 技术服务/紧急联络电话:0086-573-87538180
二、组成成分资料 纯物质: 烟酰胺含量:≥99.0% 中英文名称:3-吡啶甲酰胺(Niacinamide) 化学名称: 3-Pyridinecarboxamide 化学文摘社登记号码(CAS No.):98-92-0 欧洲现有商业化学品目录编号(EINECS No.):202-713-4
洋甘菊提取液MSDS英文版
1. IDENTIFICATION OF THE SUBSTANCE/TREPARATION AND THE COMPANY/UNDERTAKING3.HAZARDS IDENTIFICATION4. FIRST AID MEASURESMATERIAL SAFETY DATA SHEETProduct name:Supplier:Tel:EMERGENCY OVERVIEW: May cause skin irritation and/or dermatitisPrinciple routes of exposure: Inhalation: Ingestion: Skin contact: Eye contact:SkinMay cause irritation of respiratory tract May be harmful if swallowed May cause allergic skin reaction Avoid contact with eyesStatements of hazard MAY CAUSE ALLERGIC SKIN REACTION.Statements of Spill of Leak Label Eliminate all ignition sources. Absorb and/or contain spill with inert materials (e.g., sand, vermiculite). Then place in appropriate container. For large spills, use water spray to disperse vapors, flush spill area. Prevent runoff from entering waterways or sewers.General advice:POSITION/INFORMATION ON INGREDIENTSInhalation:Skin contact:Ingestion:Eye contact:Protection of first – aiders:Medical conditions aggravated by exposure: In the case of accident or if you fell unwell, seek medical advice immediately (show the label where possible).Move to fresh air, call a physician immediately.Rinse immediately with plenty of water and seek medical adviceDo not induce vomiting without medical advice.In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.No information availableNone knownSuitable extinguishing media:Specific hazards:Special protective equipment for firefighters:Flash point:Autoignition temperature:NFPA rating Use dry chemical, CO2, water spray or “alcohol” foam Burning produces irritant fumes.As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gearNot determinedNot determinedNFPA Health: 1 NFPA Flammability: 1 NFPA Reactivity: 0Personal precautions: Environmental precautions: Methods for cleaning up: Use personal protective equipment.Prevent product from entering drains.Sweep up and shovel into suitable containers for disposalStorage:7. HANDLING AND STORAGE5.FIRE-FIGHTING MEASURES6. ACCIDENTAL RELEASE MEASURESRoom temperature Handling:Safe handling advice: Incompatible products:Use only in area provided with appropriate exhaust ventilation.Wear personal protective equipment.Oxidising and spontaneously flammable productsEngineering measures: Respiratory protection: Skin and body protection:Eye protection: Hand protection: Hygiene measures:Ensure adequate ventilation.Breathing apparatus only if aerosol or dust is formed. Usual safety precautions while handling the product will provide adequate protection against this potential effect. Safety glasses with side-shieldsPVC or other plastic material glovesHandle in accordance with good industrial hygiene and safety practice.Melting point/range: Boiling point/range: Density: Vapor pressure: Evaporation rate: Vapor density: Solubility (in water): Flash point:Autoignition temperature:No Data available at this time. No Data available at this time. No data available No data available No data available No data available No data available Not determined Not determinedStability: Stable under recommended storage conditions. Polymerization: None under normal processing.Hazardous decomposition products: Thermal decomposition can lead to release of irritating gases and vapours such as carbon oxides.Materials to avoid: Strong oxidising agents.10. STABILITY AND REACTIVITY9. PHYSICAL AND CHEMICAL PROPERTIES8. EXPOSURE CONTROLS/PERSONAL PROTECTION11. TOXICOLOGICAL INFORMATIONConditions to avoid: Exposure to air or moisture over prolonged periods.Product information Acute toxicityChronic toxicity:Local effects: Chronic exposure may cause nausea and vomiting, higher exposure causes unconsciousness.Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting.Specific effects:May include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting,headache.Primary irritation: Carcingenic effects: Mutagenic effects: Reproductive toxicity:No data is available on the product itself. No data is available on the product itself. No data is available on the product itself. No data is available on the product itself.Mobility:Bioaccumulation: Ecotoxicity effects: Aquatic toxicity:No data available No data available No data availableMay cause long-term adverse effects in the aquatic environment.12. ECOLOGICAL INFORMATION13. DISPOSAL CONSIDERATIONSWaste from residues/unused products:Contaminated packaging:Waste disposal must be in accordance with appropriate Federal, State and local regulations. This product, if unaltered by use, may be disposed of treatment at a permitted facility or as advised by your local hazardous waste regulatory authority. Residue from fires extinguished with this material may be hazardous.Do not re-use empty containers.UN/Id No:Not regulated14. TRANSPORT INFFORMATIONDOTProper shipping name: Not regulatedTGD(Canada)WHMIS hazard class: Non - controlledIMDG/IMOIMDG – Hazard Classifications Not ApplicableIMO – labels:15. REGULATORY INFOTMATION International Inventories16. OTHER INFORMATIONPrepared by: Health & SafetyDisclaimer: The information and recommendations contained herein are based upon tests believed to be reliable.However, XABC does not guarantee the accuracy or completeness NOR SHALL ANY OF THIS INFORMATION CONSTITUTE A WARRANTY, WHETHER EXPRESSED OR IMPLIED, AS TO THE SAFETY OF THE GOOD, THE MERCHANTABILITY OF THE GOODS, OR THE FITNESS OF THE FITNESS OF THE GOODS FOR A PARTICULAR PURPOSE. Adjustment to conform to actual conditions of usage maybe required. XABC assumes no responsibility for results obtained or for incidental or consequential damages, including lost profits arising from the use of these data. No warranty against infringement of any patent, copyright or trademark is made or implied.End of safety data sheet。
生物增效技术在化工污水处理中的应用
TECHNOLOGY AND INFORMATION科学与信息化2023年12月下 139生物增效技术在化工污水处理中的应用於洪林江苏伊恩赛浦环保科技有限公司 江苏 宜兴 214200摘 要 随着工业化的快速发展,化工污水排放对环境造成了严重影响,加强污水处理的技术研究变得尤为重要。
生物增效技术作为一种环保、高效的处理方法,近年来在化工污水处理领域得到了广泛关注和应用。
本文对生物增效技术的概念及优势进行了简单阐述,并详细分析了该技术在化工污水处理中的应用要点及具体操作方式,希望能够为相关从业者提供一些参考建议。
关键词 生物增效技术;化工;污水处理;应用Application of Bioaugmentation Technology in Chemical Wastewater Treatment Yu Hong-linJiangsu ENSP E&P Technology Co., Ltd., Yixing 214200, Jiangsu Province, ChinaAbstract With the rapid development of industrialization, chemical wastewater discharge has a serious impact on the environment, strengthening the technical research of wastewater treatment becomes particularly important. As an environmentally friendly and efficient treatment method, bioaugmentation technology has been widely concerned and applied in the field of chemical wastewater treatment in recent years. In this paper, the concept and advantages of bioaugmentation technology are briefly described, and its application and specific operations in chemical wastewater treatment are analyzed in detail, hoping to provide some reference suggestions for relevant practitioners.Key words bioaugmentation technology; chemical industry; sewage treatment; application引言生物增效处理技术是化工污水处理领域中的一种关键方法,能够提升生物处理系统的污水降解效率。
易恩化学技术有限公司降钙素基因相关肽片段产品安全技术说明书
化学品安全技术说明书公司地址:上海化学工业区奉贤分区银工路28号E栋楼客服热线:400-133-2688 1 化学品及企业标识1.1 产品标识符化学品俗名或商品名:降钙素基因相关肽片段CAS No.:119911-68-1别名:VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2;降钙素基因相关肽(8-37);ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-ASP-PHE-LEU-SER-ARG-SER-GLY-GLY-VAL-GLY-LYS-ASN-ASN-PHE-VAL-PRO-1.2 鉴别的其他方法α-CGRP8-37FBHuman1.3 有关的确定了的物质或混合物的用途和建议不适合的用途仅供科研用途,不作为药物、家庭备用药或其它用途。
2 危险性概述2.1 GHS分类根据全球化学品统一分类和标签制度(GHS)的规定,不是危险物质或混合物。
2.2 GHS 标记要素,包括预防性的陈述2.3 其它危害物-无3 成分/组成信息3.1 物质分子式 - C139H230N44O38分子量 - 3125.59014 急救措施4.1 必要的急救措施描述一般的建议如果吸入如果吸入,请将患者移到新鲜空气处。
如果停止了呼吸,给于人工呼吸。
在皮肤接触的情况下用肥皂和大量的水冲洗。
在眼睛接触的情况下用水冲洗眼睛作为预防措施。
如果误服切勿给失去知觉者从嘴里喂食任何东西。
用水漱口。
4.2 最重要的症状和影响,急性的和滞后的据我们所知,此化学,物理和毒性性质尚未经完整的研究。
4.3 及时的医疗处理和所需的特殊处理的说明和指示无数据资料5 消防措施5.1 灭火介质火灾特征无数据资料灭火方法及灭火剂用水雾,耐醇泡沫,干粉或二氧化碳灭火。
EL-102_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :EL-102Catalog No. :HY-16187CAS No. :1233948-61-21.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:EL 102; EL102Formula:C19H16N2O3S2Molecular Weight:384.47CAS No. :1233948-61-24. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance Light yellow to yellow (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
危险化学品安全技术说明书及周知卡
危险化学品安全技术说明书及相关安全周知卡目录1、乙酸2、盐酸3、乙醇4、甲醇5、甲苯6、纯苯7、液氨8、三乙胺9、甲醛10、氯乙醛11、氯化亚砜12、二甲基甲酰胺13、水杨醛14、氢氧化钠15、碳酸钠16、碳酸钾17、三氯化铝18、乙酸酐19、对甲苯磺酰氯20、对甲氧基苯甲酸21、碘22、焦亚硫酸钠23、乙酸钠24、双氧水非常全面,给需要的同行参考。
危险化学品安全信息卡空气呼吸器。
眼睛防护:戴化学安全防护眼镜。
身体防护:穿防酸碱塑料工作服。
手防护:戴橡胶耐酸碱手套。
其他防护:工作现场严禁吸烟。
工作完毕,淋浴更衣。
注意个人清洁卫生。
急救措施皮肤接触:立即脱去污染的衣着,用大量流动清水冲洗至少15分钟。
就医。
眼睛接触:立即提起眼睑,用大量流动清水或生理盐水彻底冲洗至少15分钟。
就医。
吸入:迅速脱离现场至空气新鲜处。
保持呼吸道通畅。
如呼吸困难,给输氧。
如呼吸停止,立即进行人工呼吸。
就医。
食入:用水漱口,就医。
泄漏处理迅速撤离泄漏污染区人员至安全区,并进行隔离,严格限制出入。
切断火源。
建议应急处理人员戴自给正压式呼吸器,穿防酸碱工作服。
不要直接接触泄漏物。
尽可能切断泄漏源。
防止流入下水道、排洪沟等限制性空间。
小量泄漏:用砂土、干燥石灰或苏打灰混合。
大量泄漏:构筑围堤或挖坑收容。
喷雾状水冷却和稀释蒸汽、保护现场人员、把泄漏物稀释成不燃物。
用防爆泵转移至槽车或专用收集器内,回收或运至废物处理场所处置。
消防措施有害燃烧产物:一氧化碳、二氧化碳。
灭火方法:用水喷射逸出液体,使其稀释成不燃性混合物,并用雾状水保护消防人员。
灭火剂:雾状水、抗溶性泡沫、干粉、二氧化碳。
危险化学品安全周知卡危险性类别腐蚀品刺激性品名、英文名及分子式、CC码及CAS号醋酸(冰醋酸,乙酸)Acetic acid危险性标志危险性理化数据熔点(℃):沸点(℃):危险特性其蒸气与空气形成爆炸混合物,遇明火、高热能引起爆炸。
与强氧化剂可发生反应,与现场急救措施皮肤接触:脱去所污染的衣服,用流动清水冲洗至少15分钟;若有灼伤,就医治疗。
聚丙烯酰胺MSDS英文
Material Safety Data SheetPolyacrylamideNOT CLASSED AS HAZARDOUS ACCORDING TO CRITERIA OF WORKSAFE CHINASection 1-Chemical Product and Company Identification【Name of Goods】: Polyacrylamide【Appearance &Oder】: White crystalline power,odorless【Identity for Samples】: Chemical AnalysisCompany: XINXIANG JINGHUA WATER TREATMENT MATERIAL CO.,LTD Address: No.101, West Industrial Zone, Xinxiang, Henan, ChinaInformation Phone No: +86-373-5691222Emergency Phone No: +86-373-5691222Fax No: +86-373-5691111Section 2-Composition/Information on ingrediants【Name】: Polyacrylamide【Chemical formula】: H2 H H2 H( —C—C—) — ( —C—C—)∣m ∣n【Molecular Weight】: 5-22 million【CAS No】:9003-05-8Section 3-Hazards Identification【Most Important Hazards】: None【Adverse Human Health Effects】: None【Enviromental Effects】: None【Physical and Chemical Hazards】: NoneSection 4-First Aid Measures【Inhalation】:In case of gases evolving from melted resin,move subject to fresh air.Treat Symptomatically.【Skin Contact】:In case of pellets or powder: wash with water.In case of melt: Wash affected skin area and clothing with plentyof (soap and water.Seek medical advice.新乡市京华净水材料有限公司专业生产聚丙烯酰胺:张经理【Eye Contact】:In case of pellets or powder,flush with plenty of water for at least 15 minutes.Seek medical advice if any dust particles still remain.Incase of gases evolving from melted resin of high temperature. Flushwith plenty of water for at least l5 minutes. Seek medical advice ifnecessary.【Ingestion】:Induce vomiting.Rinse mouth with water.Seek medical advice if Necessary.Section 5-Fire Fighting Measures【Extinguishing Media】: Water,Foam,Dry chemical powder【Special Fire-Fighting Procedure】: Self contained breathing apparatus【Fire and Explosion Hazards】: NoneSection 6-Accident Release MeasuresIf spilled on road or floor, sweep and collect materials to prevent slipping all fal1ing,Released materials must be collected for environmental protection.Section 7-Handling and Storage【Handling】: Prevent from fire around handling area.Maintain good house keeping standards to prevent accumulation of dust.To avoid dust explosion,resulting from the existence of powder,electrostatics eliminatorsand grounding should be fixed to such equipment as air transferringpipes,bag filters and hoppers. Use electrically conductive filters forbag filters.【Storage】: Keep the materials at a cool dry place. Protect from direct sunlight, rain and violent temperature fluctuation. Fire is inhibited around storagearea.Section 8-Physical and Chemical Properties【Threshold Limit Value】: Not determined【Ventilation】: Necessary to exclude dust, fumes and gases.【Personal Protection Eye】:Wear safety glasses for general purpose.WearChemical goggles for cleaning moldingmachines.【Respiratory】: Wear masks for cleaning molding machines.【Gloves】: Necessary for handling melted resin.Section 9-Physical and Chemical Properties【Appearance】: White crystalloid【Boiling Point Temperature】: Above 104℃【Solubility】: Insoluble in water【Specific Gravity】: 1.13Section10-Stability and Reactivity【Flammability】: No information【Flash Point】: No determined【Auto-ignition Temperature】: No【Reactivity with Water】: No【Stability】: Stable and non—reactive under normalhandling and storage condition.【Thermal Decomposition Gases】: CO,SM and MMA ZOWO TECHNOLOGYSection 11-Toxico Logical Information【Irritation】: Fumes or vapors generated from decomposing resin maybe irritant to eyes.【Acute Oral Toxicity】: Oral LDco(rat)>5g/kg(Assumed value) 【Mutagenicity】: No determinedSection 12-Ecological InformationTo avoid being taken by ocean species or birds, disposal of the waste to the ocean and water sources is inhibited.Section 13-Disposal ConsiderationsControlled incineration or landfill according to local, state or national 1aws and regulations concerning health and pollution.Inadequate incineration may generate toxic gases such as CO,MMA and SM.Section 14-Transport InformationAvoid moisture and rough handling which may damage its package, if bag is broken and the materials are spilled,sweep and collect them immediately to prevent spilling and falling.Section 15-Regulatory Information Comply with national and local regulations.Section 16-OthersNone'。
CAS184475-55-6_Gefitinib hydrochloride基本参数MedBio
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED13690
SMI-4a
SMI-4a
438190-29-5
50mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED13689
BMS-911543
BMS-911543
1271022-90-2
10mg
≥98%
品牌
货号
25mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
Байду номын сангаас纯度
MedBio
MED13705
HO-3867
HO-3867
1172133-28-6
5mg
≥98%
熔点
无资料
闪点
321.3ºC
2、技术资料:
体外研究
吉非替尼(0.01-0.1mM)导致受体的磷酸酪氨酸负荷增加,ERK信号传导增加和刺激增殖和锚定非依赖性生长,可能是通过在EGFRvIII表达细胞的长期暴露中诱导EGFRvIII二聚化。另一方面,吉非替尼(1-2 mM)显着降低EGFRvIII磷酸酪氨酸负荷,EGFRvIII介导的增殖和不依赖贴壁的生长[1]。吉非替尼(ZD1839)抑制这些EGF驱动的未转化细胞的单层生长,IC50为20 nM [2]。吉非替尼可抑制CALU-3和GLC82细胞增殖,IC50为2μM[3]。
CAS
1、产品物理参数:
常用名
4-(3-氯-4-氟苯基氨基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉盐酸盐
伊利替康 结构式 -回复
伊利替康结构式-回复伊利替康(Elidel)是一种局部用药治疗湿疹(atopic dermatitis)的药物。
它的主要成分是酯类化合物pimecrolimus。
伊利替康是一种非激素药物,被广泛使用于针对湿疹患者的长期治疗中,有效减轻患者的症状,并且具有较少的副作用。
本文将详细解析伊利替康的结构式,为读者提供更深入的了解。
首先我们来看一下伊利替康的结构式:酯类化合物pimecrolimus的化学名为(1S, 9S, 12S, 13E, 21R, 23R)-9, 21-dihydroxy-12-isopropyl-12-(2-methyl-1-oxobutoxy)-2,5,11,13,1 9-pentamethyl-8,21-dioxo-1H,20H-[1,4]oxazino[3,4]quinolizino[2,1 -a]isoquinoline-13-yl-2-methylpropanoate。
分析伊利替康的结构式,我们可以看到它由几个部分组成。
首先是氧杂吡咯(oxazino)的环结构,它是伊利替康的骨架。
吡咯环上连接着一个氮杂喹啉环(quinolizino)和一个异戊酸酯侧链。
在氮杂喹啉环上有一个吡美沙酮(pimecrolimus)基团。
伊利替康的结构中还有一些关键的官能团。
首先是两个羟基基团(hydroxyl group),它们分别连接在吡美沙酮基团的2号和21号碳原子上。
这些羟基基团在药效中扮演着重要的角色。
接下来是一个异丙基基团(isopropyl group),连接在吡美沙酮基团的12号碳原子上。
最后是一个异丁基基团(2-methyl-1-oxobutoxy),连接在吡美沙酮基团的12号羟基上。
伊利替康属于一类被称为calcineurin抑制剂(calcineurin inhibitors)的药物。
它通过抑制T细胞的活化和炎性细胞因子的释放,从而减轻过敏反应引起的炎症和瘙痒症状。
与传统的皮质类固醇类药物(如氢化可的松)相比,伊利替康作用于皮肤外层而不影响全身免疫系统,因此具有较少的副作用,尤其是在儿童和长期使用患者中。
5种卤代乙酰胺类消毒副产物对小鼠淋巴瘤细胞Tk基因致突变性研究
括 Tk 位点在 内 的 大 缺 失、易 位、重 组 甚 至 染 色 体
种 DBPs 提出限量控制要求ꎬ我国« 生活饮用水卫生
非整倍性等广泛的遗传学改变ꎮ 欧美国家均已将
标准» 也将 13 种 DBPs 纳入控制范围(包括三卤甲
其列为一组 必 选 的 遗 传 毒 性 测 试ꎬ我 国 亦 将 其 列
烷类、卤乙酸类、卤酸盐、卤乙腈等)ꎮ 近年来随着污
中文名
英文名
分子式
缩写
Chinese name
English name
Molecular formula
Abbrevation
一氯乙酰胺
Chloroacetamide
C2 H4 ClNO
CAcAm
79 ̄07 ̄2
二氯乙酰胺
Dichloroacetamide
C2 H3 Cl2 NO
DCAcAm
683 ̄72 ̄7
摘要: 卤代乙酰胺类(HAcAm)消毒副产物(DBPs)是饮用水中新兴含氮类 DBPs 之一ꎮ 为探究 HAcAms 的致突变性ꎬ选择小鼠
淋巴瘤细胞作为受试细胞ꎬ分别考察了一氯代乙酰胺、二氯代乙酰胺、三氯代乙酰胺、一碘代乙酰胺、二碘代乙酰胺(DIAcAms)
共 5 种 HAcAms 对小鼠淋巴瘤细胞 Tk 基因突变的影响ꎮ 结果表明ꎬ在 0.05 ~ 20 μmolL ̄1 暴露浓度下ꎬ5 种 HacAms 类 DBPs
min 灭活)制成ꎮ L5178Y 细胞液氮下保存ꎬ复苏后
常规开放式悬浮培养于 RPMI ̄10ꎬ在 37 ℃、5% CO 2
条件下培养至稳定的对数增长状态ꎬ细胞密度维持
在 1 × 10 6mL  ̄1 以下ꎬ 使用时传代不应超过 10 代ꎮ
烷基化试剂
鸟嘌呤 Guanine
O HN H2N
N DNA Monoalkylated adduct
N DNA
Guanine-Guanine link
Once alkylation occurs, the alkylated sites become prone to cleavage
2. Melphalan (美法伦)
O O N P HN
Cl
Cyclophosphamide (环磷酰胺)
Cl O O N P HN Cl CYP450 Liver Cl Cl O O N P HN OH Cl normal tissue normal tissue Cl O O N P HN Cl O Cl Cl O ON P + NH2 O H alkylating group Tumor Non enzymatic Cl O O N P NH2 Cl OH O Cl O O N P NH2 H O
Cl N Cl
H2 N COOH
L-
L-Phenylalanine mustard or L-PAM L-PAM can be preferentially transported into cells, with the assistance of L-amino acid active transporter
Cl
H
vinyl diazotic acid -OH N2
N N N O cyclic oxazolidine
Reactive species
+ H2O -CO2 H2N Cl
Reactive species
H2C CH vinyl cation
Reactive species
德谷门冬双胰岛素注射液治疗2_型糖尿病临床效果及安全性探讨
DOI:10.16658/ki.1672-4062.2023.17.098德谷门冬双胰岛素注射液治疗2型糖尿病临床效果及安全性探讨林生,谢平,陈予福州市长乐区人民医院内分泌科,福建福州350200[摘要]目的研究德谷门冬双胰岛素注射液治疗2型糖尿病的临床效果及安全性。
方法选取于2022年7月—2023年4月福州市长乐区人民医院收治的2型糖尿病患者98例为研究对象,采用随机抓阄法分为两组,每组49例。
两组均联用常规降糖药物治疗,对照组采用甘精胰岛素注射液治疗,观察组采用德谷门冬双胰岛素注射液治疗。
对比两组临床治疗效果、临床症状好转时间和胰岛素用量情况、糖代谢指标、胰岛素功能指标、不良反应发生情况、心血管不良事件发生情况。
结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。
观察组尿酮体转阴时间、血糖达标时间、胰岛素用量均优于对照组,差异有统计学意义(P< 0.05)。
观察组空腹血糖、餐后2 h血糖、糖化血红蛋白均低于对照组,差异有统计学意义(P<0.05)。
观察组胰岛β细胞功能指数高于对照组,胰岛素抵抗指数、空腹胰岛素低于对照组,差异有统计学意义(P<0.05)。
两组恶心呕吐、倦怠乏力、低血糖总发生率比较,差异无统计学意义(P>0.05)。
两组心绞痛、心力衰竭总发生率比较,差异无统计学意义(P>0.05)。
结论德谷门冬双胰岛素注射液治疗2型糖尿病临床效果显著优于甘精胰岛素注射液,但是治疗安全性无显著变化。
[关键词] 2型糖尿病;德谷门冬双胰岛素注射液;不良反应;心血管不良事件[中图分类号] R59 [文献标识码] A [文章编号] 1672-4062(2023)09(a)-0098-04Discussion on the Clinical Effect and Safety of Insulin Degludec and Insu⁃lin Aspart Injection in the Treatment of Type 2 Diabetes MellitusLIN Sheng, XIE Ping, CHEN YuDepartment of Endocrinology, Changle District People's Hospital, Fuzhou, Fujian Province, 350200 China[Abstract] Objective To study the clinical effect and safety of insulin degludec and insulin aspart injection in the treatment of type 2 diabetes mellitus. Methods A total of 98 patients with type 2 diabetes admitted to Fuzhou Changle District People's Hospital from July 2022 to April 2023 were selected as the study objects and divided into two groups with 49 cases in each group by random lottery method. Both groups were treated with conventional hypoglycemic drugs, the control group was treated with insulin glargine injection, and the observation group was treated with Degu asparton double insulin injection. The clinical therapeutic effect, time of improvement of clinical symptoms, insulin dosage, glucose metabolism index, insulin function index, occurrence of adverse reactions and cardiovascular adverse events were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The time of urine ketone body turning negative, blood glucose reaching standard and insulin dosage in observation group were better than those in control group, and the differences were statistically significant (P<0.05). Fasting plasma glucose, 2-hour postprandial blood glucose and glycated hemoglobin in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). The function index of islet β cells in observation group was higher than that in control group, the insulin resistance index and fasting insulin was lower than that in control group, the dif⁃ference was statistically significant (P<0.05). There was no statistically significant difference in the total incidence of [作者简介]林生(1981-),男,本科,副主任医师,研究方向为糖尿病及其并发症的相关临床研究。
聚丙烯酰胺MSDS
聚丙烯酰胺MSDS产品名称:聚丙烯酰胺(Polyacrylamide)化学品识别码:CAS号xxxx-xx-x物质及公司标识:- 产品名称:聚丙烯酰胺- 化学品识别码:CAS号xxxx-xx-x- 制造商/供应商:ABC化学有限公司- 地址:XXX街道,XXX城市,XXXX省,XXXXX国家- 联系- 紧急危险性概述聚丙烯酰胺是一种化学物质,可能对健康和环境产生一定的危害。
以下是一些可能的危险性:- 可能对眼睛和皮肤有刺激性;- 长时间接触可能导致过敏反应;- 非常高浓度的聚丙烯酰胺溶液可能对水生生物有毒性;- 避免与酸性物质接触,可能产生有害物质。
急救措施在使用聚丙烯酰胺时,如果发生事故或不适情况,应立即采取以下急救措施:- 皮肤接触:立即用大量清水冲洗受影响区域,如有必要,请寻求医疗帮助;- 眼睛接触:立即用大量清水冲洗至少15分钟,保持眼睛张开,寻求医疗帮助;- 吸入:将受害人从暴露环境中移开,并保持呼吸道通畅。
如出现呼吸困难,立即请求紧急医疗帮助;- 摄入:不要催吐,给受害人喝大量清水,立即寻求医疗帮助。
防护措施使用聚丙烯酰胺时,请遵循以下防护措施:- 在操作过程中戴上适当的防护手套、眼镜和呼吸防护设备;- 避免与皮肤、眼睛和衣物直接接触;- 使用通风良好的场所进行操作;- 遵循相关法规和安全操作规程。
泄漏处理在处理聚丙烯酰胺的泄漏事故时,请采取以下措施:- 确保自身安全,戴上适当的防护装备;- 隔离泄漏区域,防止进一步扩散;- 排除可能导致火灾或爆炸的源头;- 使用适当的吸收材料,将泄漏物吸取或收集起来;- 将泄漏物装入合适的中,并妥善处理;- 清洗受影响区域,并进行适当的废物处理。
废弃处置在处理废弃聚丙烯酰胺时,请遵循当地法规和安全操作规程。
以下是一些常见的废弃处置方法:- 尽量减少废弃物的产生;- 将废弃物妥善密封,并妥善标识;- 根据当地法规和要求进行妥善处置;- 避免将废弃物排入水体或环境中。
317种化学物质IDLH(立即威胁生命和健康浓度)
317种化学物质IDLH(立即威胁生命和健康浓度)附录B:IDLH浓度本附录提供的IDLH浓度采纳自美国国家职业安全卫生研究所(NIOSH)正式出版物DHHS No。
90-117版本的IDLH浓度。
具体浓度请参见表B.1.表B.1 IDLH浓度序号。
污染物中文名称。
污染物英文名称。
浓度(PPM)系数(2()C)。
IDLH浓度(mg/m3)(20C)1.乙醛。
acetaldehyde。
acetic aldehyde。
10,000.18,0002.乙酸,醋酸。
acetic acid。
1,000.2,5003.乙酸酊,醋酸酊。
acetic anhydride。
1,000.4,2004.丙酮,阿西通。
acetone。
20,000.18,0005.乙腊,甲基割。
acetonitrile。
methyl cyanide。
4,000.6,8006.四溴乙烷。
acetylene tetrabromide。
tetrabromoethane。
6.17.乙烯醛。
acrolein。
allyl aldehyde。
500.2,5008.丙烯睛,乙烯基睛。
acrylonitrile。
vinyl cyanide。
150.4,2009.艾氏剂。
aldrin。
300.18,00010.烯丙醇。
allyl alcohol。
270.6,80011.烯丙卤代烷。
allyl chloride。
500.1,00012.烯丙环氧乙烷。
allyl glycidyl ether。
4,000.4,20013.2-氨基吡啶。
2-aminopyridine。
9,000.5,41014.氨。
ammonia。
100.5,41015.硫酸铵。
ammonium sulfamate。
14.37.3.87016.戊酸乙酯。
n-amyl acetate。
40.1,00017.异戊酸乙酯。
sec-amyl acetate。
95.2,50018.氨基苯。
aminobenzene。
德谷门冬双胰岛素注射液治疗2_型糖尿病的疗效及安全性研究
DOI:10.16658/ki.1672-4062.2023.19.084德谷门冬双胰岛素注射液治疗2型糖尿病的疗效及安全性研究戴卉,张开凤,朱凤丽江苏省镇江市丹徒区人民医院内分泌科,江苏镇江212000[摘要]目的探讨德谷门冬双胰岛素注射液在2型糖尿病中的效果以及安全性。
方法选取2022年1月—2023年7月江苏省镇江市丹徒区人民医院收治的62例2型糖尿病患者为研究对象,按随机数表法分为对照组(n=31)和观察组(n=31)。
对照组患者接受门冬胰岛素30注射液治疗,观察组患者接受德谷门冬双胰岛素注射治疗。
对比两组患者临床疗效、血糖变化和不良反应发生率。
结果观察组治疗有效为96.77%,高于对照组的77.42%,差异有统计学意义(χ2=5.167,P=0.023)。
治疗前,两组患者血糖水平比较,差异无统计学意义(P>0.05);治疗后,两组患者血糖水平均改善,且观察组血糖指标低于对照组,差异有统计学意义(P< 0.05)。
观察组不良反应发生率低与对照组,差异有统计学意义(P<0.05)。
结论德谷门冬双胰岛素的应用可以明显改善2型糖尿病患者血糖水平,疗效更为确切,且安全性更高,不会增加用药后不良反应。
[关键词] 2型糖尿病;德谷门冬双胰岛素;门冬胰岛素30注射液;安全性[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062(2023)10(a)-0084-04Study on the Efficacy and Safety of Insulin Degludec and Insulin Aspart Injection in the Treatment of Type 2 Diabetes MellitusDAI Hui, ZHANG Kaifeng, ZHU FengliDepartment of Endocrinology, Zhenjiang Dantu District People's Hospital, Zhenjiang, Jiangsu Province, 212000 China [Abstract] Objective To explore the effect and safety of insulin degludec and insulin aspart injection in type 2 diabe⁃tes mellitus.Methods 62 patients of type 2 diabetes mellitus patients admitted to Zhenjiang Dantu District People's Hospital, Jiangsu Province from January 2022 to July 2023 were selected as study objects and divided into the control group (n=31) and the observation group (n=31) by taking the random number table method. The patients in the control group were treated with insulin aspart 30 injection and the patients in the observation group were treated with insulin degludec and insulin aspart injection. Compared the clinical efficacy, the changes in blood glucose and the incidence of adverse reactions between the two groups of patients.Results The treatment effectiveness of the observation group was 96.77%, which was higher than that of the control group, which was 77.42%, and the difference was statistically significant (χ2=5.167, P=0.023). There was no statistically significant difference in blood glucose levels between the two groups before treatment (P>0.05). After treatment, blood glucose levels improved in both groups, and the level of blood glucose in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion The application of insulin degludec and in⁃sulin aspart can significantly improve the blood glucose level of patients with type 2 diabetes mellitus, the efficacy is more accurate, and the safety is higher, and it will not increase the occurrence of adverse reactions after the use of medication.[作者简介]戴卉(1985-),女,本科,主治医师,研究方向为内分泌科。
吲哚英文版MSDS
MSDS29.10.2015 SECTION 1:Identification of the substance/mixture and of the company/undertaking1.1 Product identifiersProduct name :IndoleProduct Number : I3408Brand : AldrichREACH No. : A registration number is not available for this substance as the substanceor its uses are exempted from registration, the annual tonnage does notrequire a registration or the registration is envisaged for a laterregistration deadline.CAS-No. : 120-72-91.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances1.3 Details of the supplier of the safety data sheetCompany : HuBei SiBo Technology Co.,Ltd.FanHu Industrial parkPanJiaWan Town437200 XianNing Hubei,CHINA湖北斯柏生物科技有限公司湖北省咸宁市嘉鱼县潘家湾镇畈湖工业园邮政编码:437200Telephone : +86 0715-*******Fax : +86 0715-*******1.4 Emergency telephone numberEmergency Phone # : +86 0715-*******SECTION 2: Hazards identification2.1 Classification of the substance or mixtureClassification according to Regulation (EC) No 1272/2008Acute toxicity, Oral (Category 4), H302Acute toxicity, Dermal (Category 3), H311Skin irritation (Category 2), H315Serious eye damage (Category 1), H318Specific target organ toxicity - single exposure (Category 3), H335Acute aquatic toxicity (Category 1), H400For the full text of the H-Statements mentioned in this Section, see Section 16. Classification according to EU Directives 67/548/EEC or 1999/45/ECXn, N Harmful, Dangerous for theenvironmentR21/22, R37/38, R41, R50/53For the full text of the R-phrases mentioned in this Section, see Section 16.2.2 Label elementsLabelling according Regulation (EC) No 1272/2008Signal word DangerHazard statement(s)H302 Harmful if swallowed.H311 Toxic in contact with skin.H315 Causes skin irritation.H318 Causes serious eye damage.H335 May cause respiratory irritation.H400 Very toxic to aquatic life.Precautionary statement(s)P261 Avoid breathing dust.P273 Avoid release to the environment.P280 Wear protective gloves/ eye protection/ face protection.P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.P312 Call a POISON CENTER or doctor/ physician if you feel unwell.Supplemental HazardStatementsnone2.3 Other hazardsStench.SECTION 3: Composition/information on ingredients3.1 SubstancesSynonyms : 1H-Benzo[b]pyrroleFormula : C8H7NMolecular Weight : 117,15 g/molCAS-No. : 120-72-9EC-No. : 204-420-7Hazardous ingredients according to Regulation (EC) No 1272/2008Component Classification ConcentrationIndoleAcute Tox. 4; Acute Tox. 3;Skin Irrit. 2; Eye Dam. 1;STOT SE 3; Aquatic Acute 1;H302, H311, H315, H318,H335, H400-Hazardous ingredients according to Directive 1999/45/ECComponent Classification ConcentrationIndoleXn, N, R21/22 - R37/38 - R41- R50/53-For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16SECTION 4: First aid measures4.1 Description of first aid measuresGeneral adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contactWash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.In case of eye contactRinse thoroughly with plenty of water for at least 15 minutes and consult a physician.If swallowedNever give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2) and/or insection 114.3 Indication of any immediate medical attention and special treatment neededno data availableSECTION 5: Firefighting measures5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.5.2 Special hazards arising from the substance or mixtureCarbon oxides, nitrogen oxides (NOx)5.3 Advice for firefightersWear self contained breathing apparatus for fire fighting if necessary.5.4 Further informationno data availableSECTION 6: Accidental release measures6.1 Personal precautions, protective equipment and emergency proceduresWear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.For personal protection see section 8.6.2 Environmental precautionsPrevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.6.3 Methods and materials for containment and cleaning upPick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.6.4 Reference to other sectionsFor disposal see section 13.SECTION 7: Handling and storage7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols.Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.For precautions see section 2.2.7.2 Conditions for safe storage, including any incompatibilitiesStore in cool place. Keep container tightly closed in a dry and well-ventilated place.Air and light sensitive.7.3 Specific end use(s)A part from the uses mentioned in section 1.2 no other specific uses are stipulatedSECTION 8: Exposure controls/personal protection8.1 Control parametersComponents with workplace control parameters8.2 Exposure controlsAppropriate engineering controlsAvoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.Personal protective equipmentEye/face protectionFace shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin protectionHandle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC andthe standard EN 374 derived from it.Full contactMaterial: Nitrile rubberMinimum layer thickness: 0,11 mmBreak through time: 480 minMaterial tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)Splash contactMaterial: Nitrile rubberMinimum layer thickness: 0,11 mmBreak through time: 480 minMaterial tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)datasource:KCLGmbH,D-36124Eichenzell,phone+49(0)665987300,******************,test method: EN374If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and mustbe evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.Body ProtectionComplete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protectionWhere risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards suchas NIOSH (US) or CEN (EU).Control of environmental exposurePrevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.SECTION 9: Physical and chemical properties9.1 Information on basic physical and chemical propertiesa) Appearance Form: flakesColour: light brownb) Odour no data availablec) Odour Threshold no data availabled) pH no data availablee) Melting point/freezingpointMelting point/range: 51 - 54 °C - lit.f) Initial boiling point andboiling range253 - 254 °C - lit.g) Flash point 121 °C - closed cuph) Evapouration rate no data availablei) Flammability (solid, gas) no data availablej) Upper/lowerflammability orexplosive limitsno data availablek) Vapour pressure no data availablel) Vapour density no data availablem) Relative density no data availablen) Water solubility no data availableo) Partition coefficient: noctanol/waterno data availablep) Auto-ignitiontemperatureno data availableq) Decompositiontemperatureno data availabler) Viscosity no data availables) Explosive properties no data availablet) Oxidizing properties no data available9.2 Other safety informationno data availableSECTION 10: Stability and reactivity 10.1 Reactivityno data available10.2 Chemical stabilityStable under recommended storage conditions. 10.3 Possibility of hazardous reactions no data available10.4 Conditions to avoidAir Light.10.5 Incompatible materialsStrong oxidizing agents, Iron and iron salts.10.6 Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5SECTION 11: Toxicological information11.1 Information on toxicological effectsAcute toxicityLD50 Oral - rat - 1.000 mg/kgLD50 Dermal - rabbit - 790 mg/kgSkin corrosion/irritationSerious eye damage/eye irritationEyes - rabbitResult: Severe eye irritation - 24 hRespiratory or skin sensitisationno data availableGerm cell mutagenicityno data availableCarcinogenicityCarcinogenicity - mouse - SubcutaneousTumorigenic:Equivocal tumorigenic agent by RTECS criteria. Lungs, Thorax, or Respiration:Tumors. LeukaemiaCarcinogenicity - mouse - SubcutaneousTumorigenic:Equivocal tumorigenic agent by RTECS criteria. Tumorigenic:Tumor types after systemic administration not seen spontaneously.IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.Reproductive toxicityno data availableSpecific target organ toxicity - single exposureInhalation - May cause respiratory irritation.Specific target organ toxicity - repeated exposureno data availableAspiration hazardno data availableAdditional InformationRTECS: NL2450000Nausea, Headache, V omiting, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.SECTION 12: Ecological information12.1 ToxicityToxicity to daphnia andother aquaticinvertebratesLC50 - Daphnia magna (Water flea) - 1 mg/l - 48 hToxicity to algae Growth inhibition EC100 - Scenedesmus acuminatus - > 10 mg/l - 96 h12.2 Persistence and degradabilityno data available12.3 Bioaccumulative potentialno data available12.4 Mobility in soilno data available12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment not available as chemical safety assessment not required/not conducted 12.6 Other adverse effectsVery toxic to aquatic life.SECTION 13: Disposal considerations13.1 Waste treatment methodsProductOffer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packagingDispose of as unused product.SECTION 14: Transport information14.1 UN numberADR/RID: 2811 IMDG: 2811 IATA: 281114.2 UN proper shipping nameADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Indole)IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Indole)IATA: Toxic solid, organic, n.o.s. (Indole)14.3 Transport hazard class(es)ADR/RID: 6.1 IMDG: 6.1 IATA: 6.114.4 Packaging groupADR/RID: III IMDG: III IATA: III14.5 Environmental hazardsADR/RID: yes IMDG Marine pollutant: yes IATA: no14.6 Special precautions for userno data availableSECTION 15: Regulatory informationThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.15.1 Safety, health and environmental regulations/legislation specific for the substance or mixtureno data available15.2 Chemical Safety AssessmentFor this product a chemical safety assessment was not carried outSECTION 16: Other informationFull text of H-Statements referred to under sections 2 and 3.Acute Tox. Acute toxicityAquatic Acute Acute aquatic toxicityEye Dam. Serious eye damageH302 Harmful if swallowed.H311 Toxic in contact with skin.H315 Causes skin irritation.H318 Causes serious eye damage.H335 May cause respiratory irritation.H400 Very toxic to aquatic life.Skin Irrit. Skin irritationSTOT SE Specific target organ toxicity - single exposureFull text of R-phrases referred to under sections 2 and 3N Dangerous for the environmentXn HarmfulR21/22 Harmful in contact with skin and if swallowed.R37/38 Irritating to respiratory system and skin.R41 Risk of serious damage to eyes.R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.。
2-正丁基-4-氯-5-甲酰基咪唑-安全技术说明书MSDS
第一部分化学品及企业标识化学品中文名:2-正丁基-4-氯-5-甲酰基咪唑化学品英文名:2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde CAS No.:83857-96-9分子式:C8H11ClN2O产品推荐及限制用途:工业及科研用途。
第二部分危险性概述紧急情况概述可能导致皮肤过敏反应。
对水生生物有毒并具有长期持续影响。
GHS危险性类别皮肤致敏物类别 1危害水生环境——长期危险类别 2标签要素:象形图:警示词:警告危险性说明:H317 可能导致皮肤过敏反应H411 对水生生物有毒并具有长期持续影响●预防措施:—— P261 避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾。
—— P272 受沾染的工作服不得带出工作场地。
—— P280 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
—— P273 避免释放到环境中。
●事故响应:—— P302+P352 如皮肤沾染:用水充分清洗。
—— P333+P313 如发生皮肤刺激或皮疹:求医/就诊。
—— P362+P364 脱掉沾染的衣服,清洗后方可重新使用—— P391 收集溢出物。
●安全储存:—— P403+P235 存放在通风良好的地方。
保持低温。
—— P405 存放处须加锁。
●废弃处置:—— P501 按当地法规处置内装物/容器。
物理和化学危险:无资料。
健康危害:可能导致皮肤过敏反应。
环境危害:对水生生物有毒并具有长期持续影响。
第三部分成分/组成信息√物质混合物第四部分急救措施急救:吸入:如果吸入,请将患者移到新鲜空气处。
皮肤接触:脱去污染的衣着,用肥皂水和清水彻底冲洗皮肤。
如有不适感,就医。
眼晴接触:分开眼睑,用流动清水或生理盐水冲洗。
如有不适感,就医。
食入:饮水,禁止催吐。
如有不适感,就医。
对保护施救者的忠告:将患者转移到安全的场所。
咨询医生。
出示此化学品安全技术说明书给到现场的医生看。
对医生的特别提示:无资料。
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MSDS
1 Composition
7 Accident Release Measure
Product Name:LY2811376
Chemical Name:
CAS No.:1194044-20-68 Accident Release Measure
Appearance: light yellow to yellow(solid)
Formula:C15H14F2N4S 9 Toxicological Information
Solubility:
2 Handling and Storage
10 Regulary Information
3 Stability and Reactivity
11Disposal Considerations
CLASSIFICATION- Substance not yet fully tested.SAFETY PHASES- 26-36 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.) 36/37/38 (Irritating to eyes,respiratory system and skin.)
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
No data available.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)-Wear respirator, chemical safety goggles, rubber boots, and heavy
rubber gloves.METHODS FOR CLEANING UP-Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
STABILITY- Stable under normal handling conditions.HANDLING- Do not breathe dust. Avoid contact with eyes,
skin,and clothing.Avoid prolonged or repeated exposure.STORAGE- Store in a properly sealed container store at -20℃,shelflife is 2 years.
4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)-
DMSO Ethanol
11 Disposal Considerations 4 Hazards Identification
12 Transport Information
5 First Aid
13 Other Information
6 Fire Fighting Measures
Caution: Not fully tested. For research purposes only
Medchemexpress LLC
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide.The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Medchemexpress LLC shall not be held liable for any damage resulting from handling or from contact with the above product.
RID/ADR- Non-hazardous for road transport. IMDG- Non-hazardous for sea transport.IATA - Non-hazardous for air transport.
As specific country, federal, state and local environmental
regulations vary and change frequently we suggest you contact a local, authorized waste disposal contractor for adequate disposal.
EXTINGUISHING MEDIA Water spray- Carbon dioxide, dry chemical powder, or appropriate foam.
SPECIAL RISKS Specific Hazard(s)- Emits toxic fumes under fire conditions. SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
INHALATION- If inhaled, remove to fresh air. If not breathing give, artificial respiration. If breathing is difficult, give oxygen.SKIN CONTACT- In case of contact, immediately wash skin
with soap and copious amounts of water.EYE CONTACT- In case of contact, immediately flush eyes with
copious amounts of water for at least 15 minutes.INGESTION- If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Special indication of hazards to humans and the environment.Irritating to eyes, respiratory system and skin.
MATERIALS TO AVOID- Strong oxidizing agents.REACTIVITY- May emit toxic gasses like Carbon monoxide,Carbon dioxide, Nitrogen oxides upon thermal decomposition.
18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A
E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。