METHOD FOR PRODUCING β-ALANINAMIDES
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专利名称：METHOD FOR PRODUCING β-
ALANINAMIDES
发明人：HILDBRAND, Stefan,RUPPEN,
Thomas,VEGHINI, Dario
申请号：EP2001002349
申请日：20010302
公开号：WO01/064638P1
公开日：
20010907
专利内容由知识产权出版社提供
摘要：The invention relates to β-alaninamides of general formula (I), wherein: R1 represents hydrogen or C¿1?-C6 alkyl which is optionally substituted by hydroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, or by optionally substituted aryl or heteroaryl; R?2¿ represents hydrogen or R?1 and R2¿, together, form a group of formula -(CH¿2?)n , wherein n represents 3 or 4, and; R?3¿ represents hydrogen, a negative charge compensated for by an equivalent of an inorganic or organic cation or represents C¿1?-C6 alkyl. The β-alaninamides are produced without using an amino protective group by reacting the corresponding α-amino acid or the corresponding α-amino acid ester with a cyanoacetic acid to form a cyanoacetic acid amide and by a subsequent catalytic hydrogenation. The method is particularly suited for producing carnosine (β-alanyl-L-histidine, R?1¿ = imidazol-4-yl-methyl, R2 = R3 = H), a naturally occurring dipeptide, which is used as a food additive having an antioxidant effect.
申请人：HILDBRAND, Stefan,RUPPEN, Thomas,VEGHINI, Dario
地址：CH,CH,CH,CH
国籍：CH,CH,CH,CH
代理机构：LONZA AG
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