联合检测血清和胸水中多项肿瘤标志物对良恶性胸水的鉴别诊断价值

联合检测血清和胸水中多项肿瘤标志物对良恶性胸水的鉴别诊
断价值
岑慧;李观强;李文;周爱莲;张卫珍;许瑞环
【期刊名称】《中国医药导报》
【年(卷),期】2011(8)19
【摘要】目的:探讨联合检测血清、胸水(胸腔积液)中人组织多肽特异性抗原(TPS)、可溶性肿瘤坏死因子受体(sTNFR)、恶性肿瘤生长因子(TSGF)、癌胚抗原(CEA)、
神经元特异性烯醇化酶(NSE)、细胞角质蛋白19片断(CYFRA21-1)对良恶性胸腔
积液的鉴别诊断价值.方法:79例临床已确诊的胸腔积液患者(恶性47例,结核性32例)的血清和胸腔积液采用酶免疫法进行TPS、sTNFR、TSGF、CEA、NSE、CYFRA21-1含量测定.结果:恶性胸腔积液患者的6种肿瘤标志物水平均明显高于
良性疾病组,差异有统计学意义(P<0.05).联合检测血清及胸腔积液6项指标,平行试验对恶性胸腔积液诊断的敏感度为95.7%,特异度为59.4%,准确度为
81.0%,Youden指数为0.6,较检测单一指标提高了诊断的敏感度、准确度及Youden指数;序列试验则对恶性胸腔积液诊断的敏感度为48.9%,特异度为93.8%,准确度为67.1%,Youden指数为0.4,较检测单一指标提高诊断的特异度、准确度
及Youden指数.结论:联合检测血清、胸腔积液中TPS、sTNFR、TSGF、CEA、NSE、CYFRA21-1对良恶性胸腔积液的鉴别诊断有重要价值,能提高诊断准确率.%Objective: To determine the differential diagnostic value of joint determination of multiple indices, including TPS, sTNFR, TSGF, CEA, NSE, CYFRA21-1, in serum and pleural effusion between benign and malignant pleural exu dates.Methods: 79 patients with pleural effusion included 47
patients with malignant pleural effusion (malignant group) and 32 patients with tuberculous pleural effusion (tuberculous group).The level of TPS, sTNFR, TSGF, CEA, NSE,CYFRA21-1 were detected by terminal reaction of enzymology.Results: The level of TPS, sTNFR, TSGF, CEA, NSE,CYFRA21-1 in malignant pleural effusion were significantly higher than those in tuberculous pleural effsion (P＜0.05).By parallel test,the sensitivity, specificity, accuracy and Youden index of joint determination of 6 indexes were 95.7％, 59.4％,81.0％,0.6 respectively.And the sensitivity, accuracy and Youden index was sigificantly higher in 6 indexes compared with the single test.By serial test,the sensitivity, specificity, accuracy and Youden index of joint determination of 6 indexes were 48.9％ ,93.8％ ,67.1％ ,0.4 respectively.And the specificity, accuracy and Youden index was higher in 6 indexes significantly compared with the single test.Conclusion: The joint determination of multiple indices, including TPS, sTNFR, TSGF, CEA, NSE, CYFRA21-1 has great practical value in different benign from malign and exudate.
【总页数】3页(P90-92)
【作者】岑慧;李观强;李文;周爱莲;张卫珍;许瑞环
【作者单位】深圳市龙岗区人民医院呼吸内科,广东深圳,518172;深圳市龙岗区人民医院检验科,广东深圳,518172;广东医学院附属医院呼吸内科,广东湛江,524001;深圳市第五人民医院呼吸内科,广东深圳,518001;南方医院呼吸内科,广东广
州,510000;深圳市龙岗中心医院检验科,广东深圳,518116
【正文语种】中文
【中图分类】R561
【相关文献】
1.多种肿瘤标志物联合检测在良恶性胸水中的诊断价值 [J], 刘娟;刘纯;彭林
2.联合检测血清、腹水肿瘤标志物对良、恶性腹水的鉴别诊断价值 [J], 刘敏;董卫国;王静;郭绪峰;王军;李娇
3.多项指标联合检测对良恶性胸水的鉴别诊断价值 [J], 王爱玲;李清泉;吴小军
4.CEA和ADA联合检测对良恶性胸水的鉴别诊断价值 [J], 黄钦;李瑶
5.联合检测肿瘤标志物在鉴别良恶性胸水中的价值 [J], 刘霞秋;陈余清
因版权原因，仅展示原文概要，查看原文内容请购买。