Florfenicol_DataSheet_MedChemExpress
化学药品中英文对照
1 阿拉伯胶(Acacia)2 乙酰舒泛钾(Acesulfame Potassium)3 冰醋酸(Acetic Acid,Glacial)4 乙酰枸橼酸三丁酯(Acetyltributyl Citrate)5 乙酰枸橼酸三乙酯(Acetyltriethyl Citrate)6 人血白蛋白(A lbumin)7 乙醇(A lcohol)8 海藻酸(Alginic Acid)9 脂肪族聚酯(A liphatic Polyesters)10 阿力糖(A litame)11 杏仁油(A lmond Oil)12 维生素E(Alpha Tocopherol)13 氨溶液(A mmonia Solution)14 维生素C(Ascorbic Acid)15 棕榈酸维生素C酯(Ascorbyl Palmitate)16 阿司帕坦(Aspartame)17 绿坡缕石(Attapulgite)18 皂土(Bentonite)19 苯扎氯铵(Benzalkonium Chloride)20 苄索氯铵(Benzethonium Chloride)21 苯甲酸(Benzoic Acid)22 苯甲醇(Benzyl Alcohol)23 苯甲酸苄酯(Benzyl Benzoate)24 溴硝丙二醇(Bronopol)25 丁羟茴醚(Butylated Hydroxyanisole)26 丁羟甲苯(Butylated Hydroxytoluene)27 羟苯丁酯(Butylparaben)28 碳酸钙(Calcium Carbonate)29 无水磷酸氢钙(Calcium Phosphate, Dibasic Anhydrous)30 磷酸氢钙二水合物(Calcium Phosphate, Dibasic Dihydrate)31 磷酸钙(Calcium Phosphate, Tribasic)32 硬脂酸钙(Calcium Stearate)33 硫酸钙(Calcium Sulfate)34 低芥酸菜籽油(Canola Oil)35 卡波姆(Carbomer)36 二氧化碳(Carbon Dioxide)37 羧甲纤维素钙(Carboxymethylcellulose Calcium)38 羧甲纤维素钠(Carboxymethylcellulose Sodium)39 角叉菜胶(Carrageenan)40 蓖麻油(Castor Oil)41 氢化蓖麻油(Castor Oil,Hydro- genated)42 微晶纤维素(Cellulose,Microcr ystalline)43 粉状纤维素(Cellulose, Powdered)44 微粉硅胶微晶纤维素(Cellulose, Silicified Microcrystalline)45 醋酸纤维素(Cellulose Acetate)46 纤维醋法酯(Cellulose Acetate Phthalate)47 角豆胶(Ceratonia)48 十八十六醇(Cetostearyl A lcohol)49 西曲溴铵(Cetrimide)50 十六醇(Cetyl Alcohol)51 壳聚糖(Chitosan)15652 氯己定(Chlorhexidine)53 三氯叔丁醇(Chlorobutanol)54 氯甲酚(Chlorocresol)55 一氯二氟乙烷(Chlorodifluoroe- thane)56 氟里昂(Chlorofluorocabons)57 对氯间二甲酚(Chloroxylenol)58 胆固醇(Cholesterol)18159 枸橼酸(Citric Acid Monohydrate)60 胶态二氧化硅（微粉硅胶）(Colloidal Silicon Dioxide)61 着色剂(Coloring Agents)62 玉米油(Corn Oil)63 棉籽油(Cottonseed Oil)64 甲酚(Cresol)20865 交联羧甲纤维素钠(Croscarmellose Sodium)66 交联聚维酮(Crospovidone)67 环糊精(Cyclodextrins)68 环甲基硅酮(Cyclomethicone)69 苯甲地那铵(Denatonium Benzoate)70 葡萄糖结合剂(Dextrates)22771 糊精(Dextrin)23072 葡萄糖(Dextrose)23373 邻苯二甲酸二丁酯(Dibutyl Phthalate)74 癸二酸二丁酯(Dibutyl Sebacate)23975 二乙醇胺(Diethanolamine)24176 邻苯二甲酸二乙酯(Diethyl Phthalate)77 二氟乙烷(Difluoroethane)78 二甲硅油(Dimethicone)79 二甲醚(Dimethyl Ether)80 邻苯二甲酸二甲酯(Dimethyl Phthalate)81 二甲亚砜(Dimethyl Sulfoxide)82 多库酯钠(Docusate Sodium)25883 依地酸（乙二胺四乙酸）(Edetic Acid)84 乙酸乙酯(Ethyl Acetate)85 乙基麦芽酚(Ethyl Maltol)86 油酸乙酯(Ethyl Oleate)87 乙基香草醛(Ethyl Vanillin)88 乙基纤维素(Ethylcellulose)89 硬脂酸棕榈酸乙二醇酯(Ethylene Glycol Palmitostearate)90 羟苯乙酯(Ethylparaben)91 果糖(Fructose)92 富马酸(Fumaric Acid)93 明胶(Gelatin)94 液体葡萄糖(Glucose,Liquid)95 甘油(Glycerin)96 山萮酸甘油酯(Glyceryl Behenate)97 单油酸甘油酯(Glyceryl Monooleate)98 单硬脂酸甘油酯(Glyceryl Monostearate)99 硬脂酸棕榈酸甘油酯(Glyceryl Palmitostearate)311100 四氢呋喃聚乙二醇醚(Glycofurol)101 瓜耳胶(Guar Gum)102 七氟丙烷(HFC)(Heptafluoro- propane)103 海克西定(Hexetidine)104 烷烃类（HC) (Hydrocarbons)105 盐酸(Hydrochloric Acid)106 羟乙纤维素(Hydroxyethyl Cellulose)107 羟乙甲纤维素(Hydroxyethylmethyl Cellulose)108 羟丙纤维素(Hydroxypropyl Cellulose)109 低取代羟丙纤维素(Hydroxypropyl Cellulose,Low-substituted) 110 羟丙甲纤维素(Hypromellose)111 羟丙甲纤维素酞酸酯(Hypromellose Phthalate)112 咪唑烷脲(Imidurea)113 异丙醇(Isopropyl Alcohol)114 肉豆蔻酸异丙酯(Isopropyl Myristate)115 棕榈酸异丙酯(Isopropyl Palmitate)116 白陶土(Kaolin)117 乳酸(Lactic Acid)118 拉克替醇(Lactitol)119 乳糖(Lactose)120 羊毛脂(Lanolin)121 含水羊毛脂(Lanolin,Hydrous)122 羊毛醇(Lanolin Alcohols)123 卵磷脂(Lecithin)124 硅酸镁铝(Magnesium Aluminum Silicate)125 碳酸镁(Magnesium Carbonate)126 氧化镁(Magnesium Oxide)127 硅酸镁(Magnesium Silicate)128 硬脂酸镁(Magnesium Stearate)129 三硅酸镁(Magnesium Trisilicate)130 苹果酸(Malic Acid)131 麦芽糖醇(Maltitol)132 麦芽糖醇溶液(Maltitol Solution)133 麦芽糖糊精(Maltodextrin)134 麦芽酚(Maltol)135 麦芽糖(Maltose)136 甘露醇(Mannitol)137 中链脂肪酸甘油三酯(Medium-chain Triglycerides)138 葡甲胺(Meglumine)139 薄荷脑(Menthol)140 甲基纤维素(Methylcellulose)141 羟苯甲酯(Methylparaben)142 液体石蜡(Mineral Oil)143 轻质液体石蜡(Mineral Oil, Light)144 液体石蜡羊毛醇(Mineral Oil and Lanolin Alcohols)145 单乙醇胺(Monoethanolamine)146 谷氨酸一钠(Monosodium Glutamate)147 硫代甘油(Monothioglycerol)148 氮(Nitrogen)149 一氧化二氮(Nitrous Oxide)150 油酸(Oleic Acid)151 橄榄油(Olive Oil)152 石蜡(Paraffin)153 花生油(Peanut Oil)154 凡士林(Petrolatum)155 凡士林羊毛醇(Petrolatum and Lanolin A lcohols)156 苯酚(Phenol)157 苯氧乙醇(Phenoxyethanol)158 苯乙醇(Phenylethyl Alcohol)159 醋酸苯汞(Phenylmercuric Acetate)160 硼酸苯汞(Phenylmercuric Borate)161 硝酸苯汞(Phenylmercuric Nitrate)162 磷酸(Phosphoric Acid)163 波拉克林钾(Polacrilin Potassium)164 泊洛沙姆(Poloxamer)165 葡聚糖(Polydextrose)166 聚乙二醇(Polyethylene Glycol)167 聚氧乙烯(Polyethylene Oxide)168 聚(甲基)丙烯酸树脂(Polymethacr- ylates)169 聚氧乙烯烷基醚(Polyoxyethylene A lkyl Ethers)170 聚氧乙烯蓖麻油衍生物(Polyoxyeth- ylene Castor Oil Derivatives) 171 聚山梨酯(Polyoxyethylene Sorbitan Fatty Acid Esters)172 硬脂酸聚氧乙烯酯(Polyoxyethylene Stearates)173 聚醋酸乙烯酞酸酯(Polyvinyl Acetate Phthalate)174 聚乙烯醇(Polyvinyl Alcohol)175 苯甲酸钾(Potassium Benzoate)176 碳酸氢钾(Potassium Bicarbonate)177 氯化钾(Potassium Chloride)178 枸橼酸钾(Potassium Citrate)179 氢氧化钾(Potassium Hydroxide)180 焦亚硫酸钾(Potassium Metabisulfite)181 山梨酸钾(Potassium Sorbate)182 聚维酮(Povidone)183 丙酸(Propionic Acid)184 没食子酸丙酯(Propyl Gallate)185 碳酸丙烯酯(Propylene Carbonate)186 丙二醇(Propylene Glycol)187 海藻酸丙二醇酯(Propylene Glycol A lginate)188 羟苯丙酯(Propylparaben)189 糖精(Saccharin)607190 糖精钠(Saccharin Sodium)191 芝麻油(Sesame Oil)613192 虫胶(Shellac)193 二氧化硅二甲硅油(Simethi cone)194 海藻酸钠(Sodium A lginate)195 抗坏血酸钠(Sodium Ascorbate)196 苯甲酸钠(Sodium Benzoate)197 碳酸氢钠(Sodium Bicarbonate)198 氯化钠(Sodium Chloride)199 枸橼酸钠二水合物(Sodium Citrate Dihydrate)200 环拉酸钠(Sodium Cyclamate)201 氢氧化钠(Sodium Hydroxide)202 月桂硫酸钠(十二烷基硫酸钠) (Sodium Lauryl Sulfate) 203 焦亚硫酸钠(偏亚硫酸钠)(Sodium Metabisulfite)204 磷酸氢二钠(Sodium Phosphate, Dibasic)205 磷酸二氢钠(Sodium Phosphate , Monobasic)206 丙酸钠(Sodium Propionate)207 羧甲淀粉钠(Sodium Starch Glycolate)208 硬脂富马酸钠(Sodium Stearyl Fumarate)209 山梨酸(Sorbic Acid)210 山梨坦酯Sorbitan Esters(Sorbitan Fatty Acid Esters) 211 山梨醇(Sorbitol)212 大豆油(Soybean Oil)213 淀粉(Starch)214 预胶化淀粉(Starch, Pregelatinized)215 灭菌玉米淀粉(Starch,Sterilizable Maize)216 硬脂酸(Stearic Acid)217 硬脂醇(Stearyl A lcohol)218 羟糖氯(Sucralose)219 蔗糖(Sucrose)220 可压性蔗糖(Sugar, Compressible)221 蔗糖粉(Sugar,Confectioner’s)222 蔗糖球形颗粒(Sugar Spheres)223 硫酸(Sulfuric Acid)224 葵花籽油(Sunflower Oil)225 氢化植物油（硬脂）栓剂基质(Sup- pository Bases,Hard Fat) 226 滑石粉(Talc)227 酒石酸(Tartaric Acid)228 四氟乙烷(HFC)(Tetrafluoroe- thane)229 硫柳汞(Thimerosal)230 二氧化钛(Titanium Dioxide)231 西黄蓍胶(Tragacanth)232 海藻糖(Trehalose)233 三醋汀(Triacetin)234 枸橼酸三丁酯(Tributyl Citrate)235 三乙醇胺(Triethanolamine)236 枸橼酸三乙酯(Triethyl Citrate)237 香草醛(Vanillin)238 氢化植物油(Vegetable Oil, Hydrogenated)239 水(Water)240 阴离子乳化蜡(Wax,Anionic Emulsifying)241 巴西棕榈蜡(Wax,Carnauba)242 十六醇酯蜡(Wax,Cetyl Esters)243 微晶蜡(Wax,Microcrystalline)244 非离子乳化蜡(聚西托醇乳化蜡)(Wax, Nonionic Emulsifying) 245 白蜡(Wax,White)246 黄蜡(Wax,Yellow)247 黄原酸胶(Xanthan Gum)248 木糖醇(Xylitol)249 玉米朊（玉米蛋白）(Zein)250 硬脂酸锌(Zinc Stearate)。
分析化学英文词汇
absorbance吸光度acetonitrile 乙腈affinity chromatography亲和色谱法aliquot 等份（试液）aluminum foil 铝箔analytical chemistry 分析化学American Chemical Society (缩写ACS) 美国化学会beaker 烧杯bibliography 参考书目blender 混合器,搅拌机buffer solution 缓冲溶液burette 滴定管centrifugation 离心Chemical Abstracts (缩写CA) 化学文摘chemical analysis 化学分析chromatograph 色谱仪chromatogram色谱图cloud point extraction（缩写CPE）浊点萃取confidence level 置信水平conical flask 锥形瓶daughter ion 子离子Diode array detector （缩写DAD）二极管阵列检测器disperser solvent 分散剂dispersive liquid–liquid microextraction 分散液液微萃取distilled water 蒸馏水dropping pipet 滴管electrochemical analysis电化学分析electrode 电极electrolyte 电解质electromagnetic spectrum 电磁波谱electrospray ionization (缩写ESI ) 电喷雾离子化Eluate 洗出液Encyclopedia of analytical chemistry 分析化学百科全书The Engineering Index （缩写EI ）工程索引enrichment factor 富集因子Evaporative Light Scattering Detector (缩写ELSD) 蒸发光散射检测器extraction efficiency 萃取效率fluorescence荧光fluorometry荧光分析法funnel 漏斗gas chromatography–mass spectrometry (缩写GC–MS) 气相色谱-质谱gas chromatography coupled to tandem mass spectrometry （缩写GC–MS/MS）气相色谱-串联质谱gel filtration chromatography凝胶过滤色谱法gel permeation chromatography凝胶渗透色谱法graduated cylinder 量筒high performance liquid chromatography (缩写HPLC) 高效液相色谱homogenize 使均质，将……打成匀浆hydrophobic 疏水的identification 鉴定Impact Factor影响因子incubation time 温育时间Index to Scientific Technical Proceedings （缩写ISTP）科技会议录索引indicator 指示剂instrumental analysis 仪器分析interference 干扰ion exchange chromatography离子交换色谱法ion source 离子源limit of detection （缩写LOD）检出限limit of quantitation (缩写LOQ)定量限linear regression equation 线性回归方程liquid chromatography tandem mass spectrometry （缩写LC-MS/MS）液相色谱串联质谱liquid chromatography with electrospray ionization tandem mass spectrometry （缩写LC-ESI-MS/MS）液相色谱电喷雾串联质谱liquid-liquid partition chromatography 液液分配色谱法liquid-solid adsorption chromatography 液固吸附色谱法mass analyzer 质量分析器Mass Spectrometer 质谱仪mass spectrum 质谱图mass-to-charge ratio 质荷比matrix effect 基质效应maximum absorption 最大吸收maximum value 最大值measuring pipet 吸量管micelle 胶束minimum value 最小值mobile phase 流动相molarity 摩尔浓度monograph专著normal phase liquid chromatography正相液相色谱法nominal concentration 标示浓度offprint抽印本optimization 优化outlier 离群值parent ion 母离子pipette 移液管potentiometry电位法preconcentration 预浓缩primary literature一次文献qualitative Analysis 定性分析Quality assurance and quality control （缩写QA/QC）质量保证和质量控制quantitative analysis 定量分析recovery 回收率refractive index detector 折光指数检测器，示差折光检测器relative abundance 相对丰度relative standard deviation （缩写RSD）相对标准偏差reproducibility 重现性reversed phase liquid chromatography（缩写RPLC）反相液相色谱法Royal Society of Chemistry（缩写RSC）英国皇家化学会Science Citation Index （缩写SCI ）科学引文索引Science Citation Index Expanded (缩写SCIE) 科学引文索引扩展版Scientific notation 科学计数法signal to noise ratio （缩写S/N）信噪比size exclusion chromatography尺寸排除色谱法secondary literature二次文献solid-phase extraction （缩写SPE）固相萃取solid-phase microextraction （缩写SPME）固相微萃取spike 添加（v.）standard solution标准溶液stationary phase 固定相stoichiometric point化学计量点surfactant 表面活性剂supernatant 上清液syringe 注射器tap water 自来水titrant 滴定剂titration滴定Ultraviolet/Visible Spectrophotometry 紫外/可见分光光度法volumetric flask 容量瓶volumetric analysis容量分析法voltammetry 伏安法Accuracy 准确度 A measure of the agreement betweenan experimental result and its expected value. Analysis 分析A process that provides chemical or physicalinformation about the constituents in the sampleor the sample itselfAnalyte 被测物，被分析物The constituent of interest in asampleCalibration curve 校准曲线The result of a standardizationshowing graphically how a method’s signalchanges with respect to the amount of analyte. Calibration method 校准方法The basis of quantitative analysis:magnitude of measured property is proportional toconcentration of analyteChromophore 生色团 A functional group which absorbs acharacteristic ultraviolet or visible wavelength Gradient elution 梯度洗脱The process of changing the mobilephase’s solvent strength to enhance the separationof both early and late eluting solutes. Gravimetric analysis重量分析 A type of quantitative analysis in whichthe amount of a species in a material is determinedby converting the species into a product that can beisolated and weighed.Isocratic elution 等度洗脱the use of a mobile phase whosecomposition remains constant throughout theseparation.Matrix 基质All other constituents in a sample except forthe analytesMethod blank 方法空白A sample that contains all componentsof the matrix except the analyte.Outlier 离群值Data point whose value is much larger orsmaller than the remaining data.Precision 精密度An indication of the reproducibility of ameasurement or resultQuantitative analysis 定量分析The determination of the amount of asubstance or species present in a material. Quantitative transfer 定量转移The process of moving a sample fromone container to another in a manner that ensures allmaterial is transferred.Selectivity 选择性 A measure of a method’s freedom frominterferences as defined by the method’s selectivitycoefficient.Significant figures 有效数字The digits in a measured quantity,including all digits known exactly and one digit (thelast) whose quantity is uncertain. Spectrophotometry 分光光度法. An analytical method that involveshow light interacts with a substanceStock solution 储备液 A solution of known concentrationfrom which other solutions are prepared. Titration curve 滴定曲线 A graph showing the progress of atitration as a function of the volume of titrant added. V alidation （方法）确证，验证The process of verifying thata procedure yields acceptable results.titration error 滴定误差The determinate error in a titration due tothe difference between the end point and theequivalence point.1.Some key journals in Analytical Chemistry:Analytical ChemistryTrends in Analytical ChemistryJournal of Chromatography AJournal of Chromatography BAnalystAnalytica Chimica ActaTALANTACritical Reviews in Analytical ChemistryAnalytical and Bioanalytical ChemistryELECTROPHORESIS2. Types of articles published in scientific journals:Full Length Research PapersRapid CommunicationsReviewsShort CommunicationsDiscussions or Letters to the Editor(Some journals publish all types of articles, while others are devoted to only a single type.)3. The structure of a scientific paper:•Title•Authors (with affiliations and addresses)• Abstract (summary)• Key words•Introduction•Experimental•Results and discussion•Conclusion•Acknowledgement•References4. How to Read a Scientific Paper:Five Helpful Questions•1) WHY did they do this set of experiments?•2) HOW were the experiments actually done?•3) WHA T are the results?•4) WHA T can be concluded from the results?•5) Did they do everything correctly?5. Five-step analyzing process1) Identify and define the problem.2) Design the experimental procedure.3) Conduct an experiment and gather data.4) Analyze the experimental data.5) Report and suggestion.。
PHA-793887_DataSheet_MedChemExpress
Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:PHA–793887 is a novel pan–cdk inhibitor, including cdk1, cdk2, cdk4, cdk5, cdk7, and cdk9 with IC50 in the 5 to 140 nM range.IC50 Value: 8 nM (CDK2), 5 nM(CDK5), 10 nM (CDK7)Target: CDKsin vitro: PHA–793887 is cytotoxic for leukemic cell lines, including K562, KU812, KCL22, and TOM1, with IC50 of 0.3–7 μM, but it is not cytotoxic for normal unstimulated peripheral blood mononuclear cells or CD34+ hematopoietic stem cells. In colony assays,PHA–793887 shows very high activity against leukemia cell lines with IC50 less than 0.1 μM. PHA–793887 induces cell–cycle arrest,inhibits Rb and nucleophosmin phosphorylation, and modulates cyclin E and cdc6 expression at 0.2–1 μM and induces apoptosis at 5μM. PHA–793887 has low activity against CDK1, CDK4, CDK9 and GSK3β with IC50 of 60 nM, 62 nM, 138 nM and 79 nM, respectively.PHA–793887 inhibits cell proliferation of many tumor cell lines, including A2780, HCT–116, COLO–205, C–433, DU–145, A375, PC3,MCF–7, and BX–PC3, with IC50 of 88 nM–3.4 μM. PHA–793887 (1 μM) shows a decrease in the S phase, a subsequent increase of the G1 phase and a slight accumulation of G2/M phase in A2780 cells. PHA–793887 (3 μM) significantly increases G2/M phase and reduces DNA synthsis.in vivo: PHA–793887 (20 mg/kg) is effective in xenograft models of K562 and HL60 cells, primary leukemic disseminated model, and a high–burden disseminated ALL–2 model derived from a relapsed Philadelphia–positive acute lymphoid leukemia patient. PHA–793887(10–30 mg/kg) shows good efficacy in the human ovarian A2780, colon HCT–116, and pancreatic BX–PC3 carcinoma xenograft models.PROTOCOL (Extracted from published papers and Only for reference)Animal administration [1]A2780 human ovarian adenocarcinoma–bearing CD–1 nude mice (Charles River Breeding Laboratories) were treated with 15 or 30mg/kg of PHA–793887 once a day by i.v. route for 2 days. Animals were sacrificed at 1.5, 6, and 24 hours after the last treatment, and tumor slices from mice treated with compound or vehicle (n = 9 animals per group) were collected and immediately soaked inRNAlater solution (Qiagen) for gene expression analysis. For pharmacokinetic analysis, plasma samples were collected from six animals at each time interval and analyzed by liquid chromatography–tandem mass spectrometry. Data were evaluated by nonlinear mixed effect modeling. Plasma levels of the compound were fitted using a two–compartment model with bolus input and first–order output mean, and random parameters were considered in the following equation: Pi = P.exp (η). The random effects were considered normal distributed with zero mean and variance ω2.References:[1]. Locatelli G et al Transcriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin–dependent kinase inhibitor PHA–793887 inProduct Name:PHA–793887Cat. No.:HY-11001CAS No.:718630-59-2Molecular Formula:C 19H 31N 5O 2Molecular Weight:361.48Target:CDK Pathway:Cell Cycle/DNA Damage Solubility:10 mM in DMSOtumor and skin biopsies from a phase I clinical study. Mol Cancer Ther. 2010 May;9(5):1265–73.[2]. Massard C, Soria JC, Anthoney DA, Proctor A, Scaburri A, Pacciarini MA, Laffranchi B, Pellizzoni C, Kroemer G, Armand JP, Balheda R, Twelves CJ.A first in man, phase I dose–escalation study of PHA–793887, an inhibitor of multiple cyclin–dependent kinases (CDK2, 1 and 4) reveals unexpected hepatotoxicity in patients with solid tumors.Cell Cycle. 2011 Mar 15;10(6):963–70. Epub 2011 Mar 15.[3]. Alzani R, Pedrini O, Albanese C, Ceruti R, Casolaro A, Patton V, Colotta F, Rambaldi A, Introna M, Pesenti E, Ciomei M, Golay J.Therapeutic efficacy of the pan–cdk inhibitor PHA–793887 in vitro and in vivo in engraftment and high–burden leukemia models.Exp Hematol. 2010 Apr;38(4):259–269.e2. Epub 2010 Feb 16.[4]. Brasca MG, Albanese C, Alzani R, Amici R, Avanzi N, Ballinari D, Bischoff J, Borghi D, Casale E, Croci V, Fiorentini F, Isacchi A, Mercurio C, Nesi M, Orsini P, Pastori W, Pesenti E, Pevarello P, Roussel P, Varasi M, Volpi D, Vulpetti A, Ciomei M.Optimization of 6,6–dimethyl pyrrolo[3,4–c]pyrazoles: Identification of PHA–793887, a potent CDK inhibitor suitable for intravenous dosing.Bioorg Med Chem. 2010 Mar 1;18(5):1844–53. Epub 2010 Jan 25.[5]. Zoubir M, Flament C, Gdoura A, Bahleda R, Litvinova E, Soumelis V, Conforti R, Viaud S, Soria JC, Kroemer G, Zitvogel L, Chaput N.An inhibitor of cyclin–dependent kinases suppresses TLR signaling and increases the susceptibility of cancer patients to herpesviridae.Cell Cycle. 2011 Jan 1;10(1):118–26. Epub 2011 Jan 1.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
间苯三酚欧洲药典翻译
间苯三酚二水合物分子式：C6H6O3·2H2O摩尔质量：162.1CAS Number：6099-90-7用途：肌肉解挛剂系统命名：1,3,5-三羟基苯二水合物含量：99.0 % ~ 101.0 %（以无水间苯三酚计算）理化性质：外观：白色或类白色粉末溶解性：难溶于水，易溶于乙醇（96 %），部分溶于二氯甲烷鉴别：A.红外光谱（2.2.24）样品制备：事先将供试品在105 °C烘箱中干燥对比：将供试品和无水间苯三酚标准品进行图谱对比B. 薄层色谱（2.2.27）供试溶液：将0.2g供试品溶解在甲醇中，并稀释至10mL参比溶液：将0.2g无水间苯三酚标准品溶解在甲醇中，并稀释至10mL薄层板：TCL F254硅胶板流动相：无水甲酸：正己烷：乙酸乙酯= 2:37.5:62.5（体积比）用量：10 µL爬板高度：超过2/3板长检测条件：在254 nm紫外光照射下检测结果：供试溶液和参比溶液的样品点在TCL板上，应大小相似、位置一致C.干燥失重（见测试）溶解：将2.5g供试品溶解在乙醇（96 %）中，并稀释至25mL外观：溶液应澄清，并不得比参比溶液BY5（方法二）颜色更深pH：将10mL溶液用去除二氧化碳的蒸馏水稀释至100mL，测得pH应在4.0 ~ 6.0之间有关物质：液相色谱：使用前现配溶液，避光保存混合溶液：流动相B：流动相A = 10:90（体积比）供试溶液：将50mg供试品溶解在混合溶液中，并稀释至10mL参比溶液（a）：取1mL供试溶液用混合溶液稀释至100mL，后取1mL此溶液用混合溶液稀释至10mL参比溶液（b）：分别取6mg的间苯二酚（杂质B），2,3',4,5',6-五羟基联苯（杂质D），邻苯三酚（杂质A）溶解于10mL的混合溶液中，加入2mL的供试溶液并用混合溶液稀释至20mL，后取1mL此溶液用混合溶液稀释至50mL参比溶液（c）：分别取4mg的邻苯三酚（杂质A），2,3',4,5',6-五羟基联苯（杂质D），杂质E，杂质I，杂质K，杂质L溶解于10mL的混合溶液中，并用混合溶液稀释至20mL参比溶液（d）：取10mg的供试品溶解于10mL的混合溶液，加入1mL的参比溶液（c）并用混合溶液稀释至20mL色谱柱：柱长：0.25m直径：4.0mm固定相：末端修饰十八烷基硅羟基耦合极性集团R（5µm）流动相：流动相A：1.36 g/L的磷酸二氢钾并用磷酸调节pH至3.0流动相B：乙腈程序洗脱流速：1.0 mL/min检测波长：265nm注射量：供试溶液，参比溶液（a），（b），（d）各20µL杂质鉴别：对比参比溶液（d）色谱图定位鉴别杂质A, D, E, I, K and L相对保留时间：以间苯三酚为参照点（保留时间大约为12min）：impurity E = about 0.7; impurity A = about 0.9; impurity D = about 1.3; impurity B = about 1.35; impurity K = about 1.5; impurity I = about 1.8; impurity L = about 2.0系统适用性：分离度：杂质A和间苯三酚大于2.5，杂质B和D大于4.0限度：校正因子：对于计算含量，各杂质的峰面积应乘以如下的校正因子：impurity A = 0.6; impurity D = 0.2; impurity E = 0.7; impurity I = 0.6; impurity K = 0.6; impurity L = 0.4且对于杂质A, D, E, I, K, L，其峰面积不应大于参比溶液（a）中主峰峰面积的1.5倍（0.15 %）非特定杂质：对于非特定杂质，其面积不应大于参比溶液（a）中主峰峰面积（0.10 %）总杂质：面积不应大于参比溶液（a）中主峰峰面积的3.0倍（0.30 %）报告限：面积不应大于参比溶液（a）中主峰峰面积的0.5倍（0.05 %）氯含量：不应大于200 ppm将2.5mL的溶液用水稀释至15mL硫酸盐：不应大于500ppm将3mL的溶液用蒸馏水稀释至15mL干燥失重：小于1.0 %将1.000g无水间苯三酚在105 °C烘箱中干燥灼烧残渣：小于0.1 %样品检测量1.0g滴定：将0.500g供试品溶解在50mL水中，用1M氢氧化钠溶液滴定，计算计量终点1mL的1M氢氧化钠相当于63.05mg的C6H6O3保存：避光保存可能存在杂质：A. benzene-1,2,3-triol (pyrogallol),B. benzene-1,3-diol (resorcinol),D. 2,3′,4,5′,6-biphenylpentol (phloroglucide),E. benzene-1,2,4-triol,I. 2,6-dichlorophenol,K. 4-chlorobenzene-1,3-diol (4-chlororesorcinol),L. 3,5-dichloroaniline,O. 4,6-dichlorobenzene-1,3-diol (4,6-dichlororesorcinol).。
Febuxostat_DataSheet_MedChemExpress
Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:Febuxostat(TEI 6720;TMX 67 ) is selective xanthine oxidase inhibitor with Ki of 0.6 nM.IC50 value: 0.6 nM (Ki) [1]Target: xanthine oxidasein vitro: Febuxostat displays potent mixed–type inhibition of the activity of purified bovine milk xanthine oxidase, with Ki and Ki' values of 0.6 nM and 3.1 nM respectively, indicating inhibition of both the oxidized and reduced forms of xanthine oxidase [1].in vivo: Febuxostat (5–6 mg/kg/day) combined with fructose significantly lowers blood pressure, UA, triglycerides, and insulin in rats compared with fructose alone. Febuxostat (5–6 mg/kg/day) combined with fructose also reduces glomerular pressure, renal vasoconstriction, and afferent arteriolar area in rats compared with fructose alone [2]. Febuxostat prevents hyperuricemia in 5/6nephrectomy (5/6 Nx)+oxonic acid (OA)+Febuxostat(Fx) rats and ameliorates proteinuria, preserves renal function and prevents glomerular hypertension in both 5/6 nephrectomy (5/6 Nx)+vehicle (V)+Febuxostat(Fx) and 5/6 nephrectomy (5/6 Nx)+oxonic acid (OA)+Febuxostat(Fx) groups [3]. Febuxostat (5 mg/kg/d by gavage for 8 days) treatment after transverse aortic constriction (TAC)attenuates the TAC–induced left ventricular (LV) hypertrophy and dysfunction. Febuxostat blunts the TAC–induced increases innitrotyrosine (indicating reduced myocardial oxidative stress), p–Erk(Thr202/Tyr204), and p–mTOR(Ser2488), with no effect on total Erk or total mTOR [4].References:[1]. Takano Y, et al. Selectivity of febuxostat, a novel non–purine inhibitor of xanthine oxidase/xanthine dehydrogenase. Life Sci, 2005, 76(16), 1835–1847.[2]. Sánchez–Lozada LG, et al. Effects of febuxostat on metabolic and renal alterations in rats with fructose–induced metabolic syndrome. Am J Physiol Renal Physiol, 2008, 294(4), F710–F718.[3]. Sánchez–Lozada LG, et al. Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia. Nephron Physiol, 2008, 108(4), p69–p78.[4]. Xu X, et al. Xanthine oxidase inhibition with febuxostat attenuates systolic overload–induced left ventricular hypertrophy and dysfunction in mice. Card Fail, 2008, 14(9), 746–753.Product Name:Febuxostat Cat. No.:HY-14268CAS No.:144060-53-7Molecular Formula:C 16H 16N 2O 3S Molecular Weight:316.37Target:Xanthine Oxidase Pathway:Metabolic Enzyme/Protease Solubility:10 mM in DMSOCaution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@ Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
MedBio_CAS3326-32-7_技术参数
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12373
Cy5 NHSester
Cy5 NHSester
None
5mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12389
Cy7.5 carboxylic acid (non-sulfonated)
Cy7.5 carboxylic acid (non-sulfonated)
熔点
>360 °C(lit.)
闪点
382.4±32.9 °C
2、Fluorescein isothiocyanate技术资料：
体外研究
Annexin V-FITC / PI用于检测软骨细胞凋亡[1]。PEI修饰的CD与异硫氰酸荧光素（FITC）缀合以制备CDs-FITC复合物[2]。
3、Fluorescein isothiocyanate同类产品列表：
None
25mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12369
Cy5.5 NHS ester (non-sulfonated)
Cy5.5 NHS ester (non-sulfonated)
None
5mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12368
MedBio
1、Fluorescein isothiocyanate物理参数：
法舒地尔杂质谱
37
8-异喹啉磺酸乙酯
现货
38
4392-52-3
现货
39
1,3-二溴丙烷
现货
40
8-异喹啉二聚体
现货
41
5-异喹啉磺酸氮氧化物
现货
42
1，3-丙二胺
现货
43
现货
44
现货
45
现货
46
现货
47
现货
48
现货
49
现货
50
现货
51
52
湖南增达生物科技有限公司是国内研究法舒地尔药物杂质最全，杂质谱最多的企业，具有大量库存。同时具有1000多个现货药物杂质库存。
分子式：C4H17N3O2·HCl
分子量：327.83
结构式：
编号
名称
结构分子式、量
货期
FSDR-1
FasudilDimer
CAS:1337967-93-7
C25H22N4O4S2 482.58
现货
FSDR-2
Fasudil Impurity 1
C15H19ClN2O2S 326.84
现货
FSDR-3
CAS:1350827-92-7
C37H39N7O7S3 789.94
现货
FSDR-6
Fasudil Pyridine N-Oxide TFA Salt
CAS:186544-56-9(Free Amine
C37H39N7O7S3 789.94
现货
FSDR-7
现货
FSDR-9
1,4-bis(phenylsulfonyl)-1,4-diazepane
现货
22
7-位异喹啉磺酸
OXOID药敏纸片中英文对照
AAmikacin 阿米卡星（丁胺卡那霉素）AK 30µg CT0107B Amoxycillin 阿莫西林（羟氨苄青霉素）AML 2µg CT0060B Amoxycillin 阿莫西林（羟氨苄青霉素）AML 10µg CT0161B Amoxycillin 阿莫西林（羟氨苄青霉素）AML 25µg CT0061BAmoxycillin/clavulanic acid 阿莫西林／克拉维酸（棒酸）（2:1）（澳格门汀）AMC 3µg CT0538BAmoxycillin/clavulanic acid 阿莫西林／克拉维酸（棒酸）（2:1）（澳格门汀）AMC 30µg CT0223BAmpicillin 氨苄西林AMP 2µg CT0002B Ampicillin 氨苄西林AMP 10µg CT0003B Ampicillin 氨苄西林AMP 25µg CT0004B Ampicillin/sulbactam 1:1 氨苄西林/舒巴坦（1:1）SAM 20µg CT0520B Ampicillin/sulbactam 2:1 氨苄西林/舒巴坦（2:1）SAM 30µg CT1653B Apramycin 阿泊拉霉素（安普霉素）APR 15µg CT0545B Azithromycin 阿齐霉素（阿奇霉素）AZM 15µg CT0906B Aztreonam 安曲南ATM 30µg CT0264B BBacitracin 杆菌肽 B 10 units CT0005B CCarbenicillin 羧苄西林（羧苄青霉素）CAR 100µg CT0006B Cefaclor 头孢克洛（头孢克罗）CEC 30µg CT0149B Cefadroxil 头孢羟氨苄CFR 30µg CT0453B Cefamandole 头孢孟多MA 30µg CT0108B Cefepime 头孢吡肟（马斯平）FEP 30µg CT0771B Cefixime 头孢克肟（世福素）CFM 5µg CT0653B Cefoperazone 头孢哌酮（先锋必）CFP 30µg CT0193B Cefoperazone 头孢哌酮（先锋必）CFP 75µg CT0249BCefoperazone/sulbactam 2:1 头孢哌酮／舒巴坦（2：1）（舒普深）SCF 105µg CT1727BCefotaxime 头孢噻肟（凯福隆）CTX 5µg CT0407B Cefotaxime 头孢噻肟（凯福隆）CTX 30µg CT0166B Cefotetan 头孢替坦CTT 30µg CT0665B Cefoxitin 头孢西丁（美福仙）FOX 30µg CT0119B Cefpirome 头孢匹罗CPO 30µg CT1412B Cefpodoxime 头孢泊肟CPD 10µg CT1612B Cefprozil 头孢丙烯CPR 30µg CT1647B Cefsulodin 头孢磺胺（达克舒林）CFS 30µg CT0263B Ceftazidime 头孢他啶CAZ 10µg CT1629B Ceftazidime 头孢他啶CAZ 30µg CT0412B Ceftibuten 头孢布烯CFT 30µg CT1662B Ceftiofur 头孢噻呋EFT 30µg CT1751B Ceftizoxime 头孢唑肟（安保速灵）ZOX 30µg CT0477BCeftriaxone 头孢曲松（头孢三嗪）CRO 30µg CT0417B Cefuroxime sodium 头孢呋新钠CXM 5µg CT0406B Cefuroxime sodium 头孢呋新钠CXM 30µg CT0127B Cephalexin 头孢氨苄（头孢力新，先锋IV）CL 30µg CT0007B Cephalothin 头孢噻吩（头孢菌素，先锋I ）KF 30µg CT0010B Cephazolin 头孢唑啉（先锋V）KZ 30µg CT0011B Cephradine 头孢拉定（先锋VI）CE 30µg CT0063B Chloramphenicol 氯霉素 C 10µg CT0012B Chloramphenicol 氯霉素 C 30µg CT0013B Chloramphenicol 氯霉素 C 50µg CT0014B Cinoxacin 西诺沙星CIN 100µg CT0162B Ciprofloxacin 环丙沙星（悉复欢）CIP 1µg CT0623B Ciprofloxacin 环丙沙星（悉复欢）CIP 5µg CT0425B Ciprofloxacin 环丙沙星（悉复欢）CIP 10µg CT1615B Clarithromycin 克拉霉素CLR 2µg CT1599B Clarithromycin 克拉霉素CLR 5µg CT1623B Clarithromycin 克拉霉素CLR 15µg CT0693BClindamycin 克林霉素（氯林可霉素，氯洁霉素）DA 2µg CT0064BClindamycin 克林霉素（氯林可霉素，氯洁霉素）DA 10µg CT0015BCloxacillin 氯唑西林（邻氯青霉素）OB 5µg CT0016B Colistin sulphate 多粘菌素E（硫酸粘杆菌素）CT 10µg CT0017B Colistin sulphate 多粘菌素E（硫酸粘杆菌素）CT 25µg CT0065B Colistin sulphate 多粘菌素E（硫酸粘杆菌素）CT 50µg CT0664B Compound sulphonamides 磺胺复合物S3 300µg CT0059B 抗生素英文名全称中文名全称名称缩写浓度产品编号DDoxycycline 强力霉素DO 30µg CT0018B EEnrofloxacin 恩诺沙星ENR 5µg CT0639B Ertapenem 厄他培南ETP 10µg CT1761B Erythromycin 红霉素 E 5µg CT0066B Erythromycin 红霉素 E 10µg CT0019B Erythromycin 红霉素 E 15µg CT0020B Erythromycin 红霉素 E 30µg CT0021B抗生素英文名全称中文名全称名称缩写浓度产品编号FFlorfenicol 氟苯尼考FFC 30µg CT1754BFluconazole 氟康唑FCA 25µg CT1806B Flumequine 氟甲喹UB 30µg CT0666B Fosfomycin 磷霉素FOS 50µg CT0183B 抗生素英文名全称中文名全称名称缩写浓度产品编号Framycetin 新霉素B FY 100µg CT0071B Fusidic acid 褐霉素（夫西地酸）FD 5µg CT0493B Fusidic acid 褐霉素（夫西地酸）FD 10µg CT0023B Fusidic acid 褐霉素（夫西地酸）FD 50µg CT1617B GGentamicin 庆大霉素CN 10µg CT0024B Gentamicin 庆大霉素CN 30µg CT0072B Gentamicin 庆大霉素CN 120µg CT0794B Gentamicin 庆大霉素CN 200µg CT0695B IImipenem 亚胺培南（配能）IPM 10µg CT0455B KKanamycin 卡那霉素K 5µg CT0025B Kanamycin 卡那霉素K 30µg CT0026B LLatamoxef 拉氧头孢MOX 30µg CT0302B Levofloxacin 左氧氟沙星（可乐必妥）LEV 1µg CT1586B Levofloxacin 左氧氟沙星（可乐必妥）LEV 5µg CT1587B Lincomycin 林可霉素（洁霉素）MY 2µg CT0027B Lincomycin 林可霉素（洁霉素）MY 10µg CT0123B Lincomycin 林可霉素（洁霉素）MY 15µg CT0028BLincomycin/neomycin 林可霉素（洁霉素）/新霉素LN 75µg CT1757BLincomycin/spectinomycin 林可霉素/壮观霉素LS 109µg CT1758B Linezolid 利奈唑胺LZD 10µg CT1649B Linezolid 利奈唑胺LZD 30µg CT1650B Lomefloxacin 洛美沙星LOM 10µg CT1661B MMecillinam 美西林MEL 10µg CT0096B Mecillinam 美西林MEL 25µg CT0091B Meropenem 美罗培南（美平）MEM 10µg CT0774B Metronidazole 甲硝唑（灭滴灵）MTZ 5µg CT0067B Metronidazole 甲硝唑（灭滴灵）MTZ 50µg CT0466B Mezlocillin 美洛西林MEZ 30µg CT0174B Mezlocillin 美洛西林MEZ 75µg CT0192BMinocycline 米诺环素（二甲胺四环素）MH 30µg CT0030BMoxalactam 拉氧头孢MOX 30µg CT0302B Moxifloxacin 莫西沙星MXF 1µg CT1683B Moxifloxacin 莫西沙星MXF 5µg CT1633BMupirocin 莫匹罗星MUP 5µg CT0522B Mupirocin 莫匹罗星MUP 20µg CT1826B Mupirocin 莫匹罗星MUP 200µg CT0523B NNalidixic acid 萘啶酸NA 30µg CT0031B 抗生素英文名全称中文名全称名称缩写浓度产品编号Neomycin 新霉素N 30µg CT0033BNetilmicin 奈替米星（乙基西梭霉素）NET 10µg CT0424BNetilmicin 奈替米星（乙基西梭霉素）NET 30µg CT0225BNitrofurantoin 呋喃妥因（呋喃妥英） F 50µg CT0069B Nitrofurantoin 呋喃妥因（呋喃妥英） F 100µg CT0034B Nitrofurantoin 呋喃妥因（呋喃妥英） F 200µg CT0035B Nitrofurantoin 呋喃妥因（呋喃妥英） F 300µg CT0036B Norfloxacin 诺氟沙星（氟哌酸）NOR 2µg CT0687B Norfloxacin 诺氟沙星（氟哌酸）NOR 5µg CT0668B Norfloxacin 诺氟沙星（氟哌酸）NOR 10µg CT0434B Novobiocin 新生霉素NV 5µg CT0037B Novobiocin 新生霉素NV 30µg CT0038B Nystatin 制霉菌素NS 100units CT0073B OOfloxacin 氧氟沙星（泰利必妥）OFX 5µg CT0446B Oleandomycin 竹桃霉素OL 15µg CT0039B Oxacillin 苯唑西林OX 1µg CT0159B Oxacillin 苯唑西林OX 5µg CT0040B Oxolinic acid 奥索利酸（恶喹酸）OA 2µg CT0181BOxytetracycline 土霉素（氧四环素，地霉素）OT 30µg CT0041BPPefloxacin 培氟沙星（甲氟哌酸）PEF 5µg CT0661B Penicillin G 青霉素G P 1unit CT0152B Penicillin G 青霉素G P 1.5unit CT0042B Penicillin G 青霉素G P 2units CT0088B Penicillin G 青霉素G P 5units CT0124B Penicllin G 青霉素G P 10units CT0043B Penicillin/novobiocin 青霉素/新生霉素PNV 40 CT1755B Pipemidic acid 吡哌酸PIP 20µg CT0180BPiperacillin 哌拉西林（氧哌嗪青霉素）PRL 30µg CT1619BPiperacillin 哌拉西林（氧哌嗪青霉素）PRL 75µg CT0261BPiperacillin 哌拉西林（氧哌嗪青霉素）PRL 100µg CT0199BPiperacillin/tazobactam 哌拉西林/他唑巴坦（特治星）TZP 36µg CT1616B Piperacillin/tazobactam 哌拉西林/他唑巴坦（特治星）TZP 40µg CT1628B Piperacillin/tazobactam 哌拉西林/他唑巴坦（特治星）TZP 85µg CT0720B Piperacillin/tazobactam 哌拉西林/他唑巴坦（特治星） TZP 110µg CT0725B Pirlimycin 吡利霉素 PIR 2µg CT1668B Polymyxin B多粘菌素BPB300units CT0044BQQuinupristin/dalfopristin 喹奴普汀/达福普汀 QD 15µg CT1644BR抗生素英文名全称 中文名全称 名称缩写 浓度 产品编号 Rifampicin 利福平 RD 2µg CT0078B Rifampicin 利福平 RD 5µg CT0207B Rifampicin 利福平 RD 30µg CT0104BSSpectinomycin 大观霉素（壮观霉素） SH 10µg CT0046B Spectinomycin 大观霉素（壮观霉素） SH 25µg CT0411B Spectinomycin 大观霉素（壮观霉素） SH 100µg CT0823B Spiramycin 螺旋霉素 SP 100µg CT0232B Streptomycin 链霉素 S 10µg CT0047B Streptomycin链霉素 S 25µg CT0048B Sulbactam/ampicillin 1 : 1舒巴坦/氨苄西林 SAM 20µg CT0520BSulbactam/ampicillin 1 : 2 舒巴坦/氨苄西林（优立新） SAM 30µg CT1653B Sulphafurazole 磺胺异恶唑 SF300µg CT0075B Sulphamethoxazole 磺胺甲基异恶唑（新诺明） RL25µg CT0051B Sulphamethoxazole 磺胺甲基异恶唑（新诺明） RL 100µg CT0074B Sulphamethoxazole/trimethoprim 19 : 1 磺胺甲基异恶唑（新诺明）/甲氧苄氨嘧啶 SXT 25µg CT0052B Sulphonamides compound 磺胺复合物 S3 300µg CT0059BT Teicoplanin 替考拉宁（壁霉素） TEC 30µg CT0647B Telithromycin 泰利霉素 TEL 15µg CT1714B Tetracycline 四环素 TE 10µg CT0053B Tetracycline 四环素 TE 30µg CT0054B Ticarcillin 替卡西林（羧噻吩青霉TIC75µgCT0167B素）Ticarcillin/clavulanic acid 7.5 : 1 替卡西林／克拉维酸（7.5:1） TIM 85µg CT0449B Tigecycline 替加环素 TGC 15µg CT1841B Tilmicosin 替米考星 TIL 15µg CT1756B Tobramycin 妥布霉素（托普霉素） TOB 10µg CT0056B Tobramycin 妥布霉素（托普霉素） TOB 30µg CT1618B Trimethoprim 甲氧苄氨嘧啶 W 1.25µg CT0057B Trimethoprim 甲氧苄氨嘧啶 W 2.5µg CT0070B Trimethoprim 甲氧苄氨嘧啶 W 5µg CT0076B Trimethoprim/sulphamethoxazole 1:19 甲氧苄氨嘧啶/磺胺甲基异恶唑（复方新诺明） SXT 25µg CT0052B V Vancomycin 万古霉素（稳可信） VA 5µg CT0188B Vancomycin 万古霉素（稳可信） VA 30µg CT0058B Voriconazole 优立康唑 VOR 1µg CT1807B 注释： CLSI: Clinical ａnd Laboratory Standards Institute 美国临床实验室标准化研究所DIN: Deutsches Institut f ür Normung 德国标准化学会 BSAC: British Society for Antimicrobial Chemotherapy 英国抗生素化疗协会SRGA: Swedish Reference Group for Antibiotics 瑞典抗生素委员会 SFM: Soci ét é Fran çaise de Microbiologie 法国微生物学会注：红色为兽禽用抗生素，绿色为农作物用抗生素，其余为人用抗生素。
Febuxostat_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Jul.-04-2017Print Date:Jul.-04-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :FebuxostatCatalog No. :HY-14268CAS No. :144060-53-71.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4), H302Acute aquatic toxicity (Category 1), H400Chronic aquatic toxicity (Category 1), H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effects.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose of contents/ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:TEI 6720; TMX 67Formula:C16H16N2O3SMolecular Weight:316.37CAS No. :144060-53-74. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGUN number: 3077Class: 9Packing group: IIIEMS-No: F-A, S-FProper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.Marine pollutant: Marine pollutantIATAUN number: 3077Class: 9Packing group: IIIProper shipping name: Environmentally hazardous substance, solid, n.o.s.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
zif67化学式
zif67化学式阿斯匹林(乙酰水杨酸)，又称乙酰水杨酸，为白色结晶性粉末，无臭，味微酸。
在水中的溶解度甚微，在乙醇、丙酮或乙醚中溶解，微溶于氯仿，易溶于稀乙醇。
其水溶液在冷时较粘稠，加热后又变成澄清的水溶液，相对密度为1．069。
熔点188～190 ℃。
药理作用：本品对血小板聚集有抑制作用，能降低血管壁通透性，可用于高血压脑病、脑血栓形成及其他血栓栓塞性疾病。
用法用量：口服。
1。
一次0．3～0．6g，一日3次。
2。
胃及十二指肠溃疡者宜在饭后服用。
2005年2月22日，全球首个阿司匹林片剂——葛兰素史克的“泰嘉”（复方阿司匹林）片正式获得中国食品药品监督管理局批准上市，该产品是目前唯一针对心脑血管病防治的现代复方新药。
据介绍，心脑血管疾病在我国的死亡率呈逐年上升趋势，我国每年死于心脑血管病的人数超过了200万人，居世界首位。
2005年6月15日，中国科学院心理研究所组织中国健康教育协会和卫生部新闻宣传中心共同主办了大型公益活动——“心脑血管病和谐社会”大型电视论坛，到场领导、专家与现场观众就阿司匹林的临床应用、中国人群心脑血管疾病流行状况、科学防治策略等问题进行了热烈而深入的交流，许多观众看完后感慨地说：“专家们的讲座精彩极了，阿司匹林为心脑血管病防治开创了新局面。
”据悉，在此之前，美国已经于2004年12月22日将阿司匹林列为处方药，随后加拿大、德国、英国等许多国家都把阿司匹林列入处方药，以预防和控制心脑血管疾病的发生。
目前我国的心脑血管病患者已达2亿人，占全部人口的40％，每年死于心脑血管病者达130万人，约占总死亡人数的55％。
目前已经有部分国家将阿司匹林定为医保药品，然而由于价格昂贵，多数老百姓不愿购买使用。
中国卫生部副部长殷大奎近日表示，从今年起将在北京等20个城市试行阿司匹林的医保报销制度，这意味着心脑血管病患者的费用将有望得到更有效的控制。
在美国等国家，阿司匹林的实际支付费用远远低于美国联邦政府规定的年度费用标准，人们常常是自行选择购买。
【精编范文】花冠201X说明书-优秀word范文 (14页)
本文部分内容来自网络整理，本司不为其真实性负责，如有异议或侵权请及时联系，本司将立即删除！== 本文为word格式，下载后可方便编辑和修改！ ==花冠201X说明书篇一：佛司可林说明书【中文名称】：佛司可林【中文别名】：弗斯可林；毛喉萜；福斯高林【英文名称】：Forskolin【英文别名】：COLEONOL;ForsLean【CAS编号】：66575-29-9【分子结构】：【贮存条件】：4℃冷藏、密封、避光【熔点】：230-232℃【外观】：白色粉末【密度】：1.23【纯度】：HPLC≥98%【用途】：佛司可林用于含量测定/鉴定/药理实验等【溶解度】：DMSO: 5 mg/mL stable at least 6 months at room temperature【分子式】：C22H34O7【分子量】：410.50【有效期】：2年【鉴别方法】：MS，NMR【推荐测定方法】：HPLC【中国药典测定方法】：液相【注意事项】：防止阳光直射【药理药效】：具有显著的抗癌、抗病毒活性【提取来源】：毛喉鞘蕊花。
毛喉鞘蕊花，草本，直立或上升，高约40厘米。
茎粗壮，具四棱及四槽，分枝，被长柔毛。
在上部较密。
叶卵圆形，顶端钝或急尖，基部骤楔形下延成柄，边缘具圆齿，近肉质，两面密被绒毛及柔毛；叶柄长6-15毫米，密被柔毛。
轮伞花序由6-10花组成，多数排列成总状花序，总状花序长约2.3-10厘米；苞片卵圆形，长约8毫米，宽约7毫米，顶端尾状急尖，边缘具缘毛，外面被微柔毛，在开花时脱落；萼钟形，长约6毫米，喉部内面密被长柔毛，5齿，后齿大，心形，顶端短尖，余4齿近三角形，先端钻状渐尖，在果时常增大且下弯；花冠紫蓝色，长约1.2-1.5厘米，外面被稀疏的腺点，花冠管向下弯，向喉部逐渐增大宽至3.5毫米，冠檐二唇形，上唇4浅裂，裂片不相等，下唇延长，长圆形，舟状；雄蕊4，内藏或稍外露，花丝在中部以下合生成鞘状；花柱外伸。
CAS号28920-43-6_MedBio_氯甲酸-9-芴基甲酯物理参数
143.6±11.4 °C
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