Stage4.Trial

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开发新药97

开发新药从上面的表可以看到新药开发耗用巨大的时间和金钱。

新药开发大体上可以氛围五个阶段。

第一，新药候补物质发现阶段（Drug Discovery Stage）在这个阶段，首先选定治病，而对此治病有可能药效的新药候补物品约一万种检查其对治病效果如何，然后为制造新药进行物质合成的阶段。

第二，前临床检查阶段（Preclinical Stage）将从第一阶段合成做出的新药候补物质通过细胞实验和动物实验，检查其物质的安全性，毒性。

第三，临床试验阶段（Clinical Trial Stage)通过第二阶段之后，随后开发并制造预备新药。

以这预备新药对人做逐步的临床试验（3个阶段），而以从之获得的资料分析并检查适合性。

第四，新药许可阶段(New Drug Approval Stage)第五，销售阶段(Launch Stage)将完成的医药品向患者和消费者供给。

上面的全部过程不是在一两年之间完成的，若在进行过程当中出现问题，要回去前一个阶段，甚至要回到初期阶段重新开始。

b. Generic 药品若A企业开发出叫做X的Originial药品。

若这药品专利权期间结束或未得到专利，B企业利用X药品做出具有相同成分，种类，含量，效果，用法，用量的Y药品，而将Y药品经过生物学实验和同等性实验，若通过了，Y药品就是Generic（Copy）药品。

这Generic药品不能比Original药品的成分，效能高或低。

这种Generic药品的开发费用比新药开发费用很少。

新药开发过程1.前临川实验阶段( 1-3年: 平均18个月)用动物实验，检查药品的安全性，若检查结果好，可以申请临床实验。

2. 临床实验(2-10年: 平均5，6年)一. 第1阶段: 以正常人为对象，检查安全性，效果。

二. 第2阶段: 以限制的人员患者（5-150名）为对象，检查治疗效果，决定容量。

三. 第3阶段: 在限制的临床实验研究机关，以广泛的患者（一般一千到两千名）为对象，检查各种临床状态的安全性和效果。

医疗器械临床前试验入组流程

医疗器械临床前试验入组流程1.临床前试验入组前，首先需要完成患者的筛选。

Before entering the preclinical trial, patients need tobe screened first.2.筛选的标准包括年龄、性别、疾病阶段等因素。

The screening criteria include factors such as age, gender, and disease stage.3.符合筛选标准的患者将被邀请参与临床前试验。

Patients who meet the screening criteria will be invitedto participate in the preclinical trial.4.临床前试验入组前，研究人员将向患者解释试验的目的和流程。

Before entering the preclinical trial, researchers will explain the purpose and process of the trial to the patients.5.患者须签署知情同意书后方可入组。

Patients must sign an informed consent form before enrolling in the trial.6.入组前，患者需要进行一系列的身体检查。

Before enrolling, patients need to undergo a series of physical examinations.7.这些身体检查可以包括血液检测、影像学检查等。

These physical examinations may include blood tests, imaging scans, and so on.8.确认患者符合入组标准后，研究人员将记录患者的基本信息。

After confirming that the patient meets the inclusion criteria, researchers will record the patient's basic information.9.患者入组后将按照试验方案接受相应的治疗或观察。

品质保证系统流程图英文版

Strcucure/part/Pagckage 4.Part Qualify 5.Process Design 8.SetFMEA, SOP & QC Plan ..etc
Design stage for D1~D3(D1-Product planning stage/D2 Design review(For each D1~D3:Quality,requirement,special character
If If abnormal status occurs in any department , it must analysis root cause and wr
Quality Assurance Div.
Product planing Div.
eeting(Determination of Development)
Sales Plan Receive
1.Mass production 2.ManufacБайду номын сангаасure Control &
Inspection(First article/routine inspection) 3.Control and maintenance of equipment
Receive
Basic Production Planning
authority 2.Sorting out and submit 8D report
ny department , it must analysis root cause and write 8D report
accepted
Rejected
Closed
2.Correction and prevention 3.Reliability TEST 4.Calibration 5.Suppliers control and audit 1.Verify the defects and judge

402 1 电动门用户手册说明书

1FAAC S.p.A.Via Benini, 140069 Zola Predosa (BO) - ITALIATel.: 051/61724 - Fax: 051/758518www.faac.it732143 Rev.A.EC DECLARATION OF CONFORMITY FOR MACHINES ....................................................................................p. 2 WARNINGS FOR THE INSTALLER .......................................................................................................................p. 2 1.DESCRIPTION AND TECHNICAL SPECIFICATIONS ....................................................................................p. 31.1.DIMENSIONS ................................................................................................................................p. 32.ELECTRIC DEVICES (standard system) ....................................................................................................p. 33.INSTALLING THE AUTOMATED SYSTEM ......................................................................................................p. 43.1.PRELIMINARY CHECKS ................................................................................................................p. 43.2.INSTALLATION DIMENSIONS ........................................................................................................p. 43.2.1.GENERAL RULES FOR DETERMINING THE INSTALLATION DIMENSIONS ............................p. 43.3.INSTALLATION OF THE OPERATORS .............................................................................................p. 44.START-UP ....................................................................................................................................................p. 64.1.ADJUSTING THE ANTI-CRUSHING SYSTEM ..................................................................................p. 65.FINAL OPERATIONS ...................................................................................................................................p. 76.AUTOMATED SYSTEM TEST .........................................................................................................................p. 77.MANUAL OPERATION ...............................................................................................................................p. 78.RESTORING NORMAL OPERATION MODE ................................................................................................p. 79.MAINTENANCE ..........................................................................................................................................p. 710.REPAIRS .....................................................................................................................................................p. 711.TROUBLE SHOOTING .................................................................................................................................p. 821)ATTENTION! To ensure the safety of people, it is important that you readall the following instructions. Incorrect installation or incorrect use of the product could cause serious harm to people.2)Carefully read the instructions before beginning to install the product.3)Do not leave packing materials (plastic, polystyrene, etc.) within reachof children as such materials are potential sources of danger.4)Store these instructions for future reference.5)This product was designed and built strictly for the use indicated in thisdocumentation. Any other use, not expressly indicated here, could compromise the good condition/operation of the product and/or be a source of danger.6)FAAC declines all liability caused by improper use or use other than thatfor which the automated system was intended.7)Do not install the equipment in an explosive atmosphere: the presenceof inflammable gas or fumes is a serious danger to safety.8)The mechanical parts must conform to the provisions of Standards EN12604 and EN 12605.For non-EU countries, to obtain an adequate level of safety, the Standards mentioned above must be observed, in addition to national legal regulations.9)FAAC is not responsible for failure to observe Good Technique in theconstruction of the closing elements to be motorised, or for any deformation that may occur during use.10)The installation must conform to Standards EN 12453 and EN 12445.For non-EU countries, to obtain an adequate level of safety, the Standards mentioned above must be observed, in addition to national legal regulations.11)Before attempting any job on the system, cut out electrical power .12)The mains power supply of the automated system must be fitted with anall-pole switch with contact opening distance of 3mm or greater. Use of a 6A thermal breaker with all-pole circuit break is recommended.13)Make sure that a differential switch with threshold of 0.03 A is fittedupstream of the system.14)Make sure that the earthing system is perfectly constructed, andconnect metal parts of the means of the closure to it.15)The safety devices (EN 12978 standard) protect any danger areasagainst mechanical movement Risks , such as crushing, dragging,and shearing.16)Use of at least one indicator-light (e.g. FAACLIGHT ) is recommendedfor every system, as well as a warning sign adequately secured to the frame structure, in addition to the devices mentioned at point “15”.17)FAAC declines all liability as concerns safety and efficient operationof the automated system, if system components not produced by FAAC are used.18)For maintenance, strictly use original parts by FAAC.19)Do not in any way modify the components of the automated system.20)The installer shall supply all information concerning manual operationof the system in case of an emergency, and shall hand over to the user the warnings handbook supplied with the product.21)Do not allow children or adults to stay near the product while it isoperating.22)Keep remote controls or other pulse generators away from children,to prevent the automated system from being activated involuntarily.23)Transit through the leaves is allowed only when the gate is fully open.24)The user must not attempt any kind of repair or direct action whateverand contact qualified personnel only.25)Maintenance: check at least every 6 months the efficiency of thesystem, particularly the efficiency of the safety devices (including,where foreseen, the operator thrust force) and of the release devices.26)Anything not expressly specified in these instructions is not permitted.WARNINGS FOR THE INSTALLERGENERAL SAFETY OBLIGATIONSEC DECLARATION OF CONFORMITY FOR MACHINES(DIRECTIVE 98/37/EC)Manufacturer:FAAC S.p.A.Address:Via Benini, 1 - 40069 Zola Predosa BOLOGNA - ITALY Declares that:402 mod. operator,•is built to be integrated into a machine or to be assembled with other machinery to create a machine under the provisions of Directive 98/37/EC;•conforms to the essential safety requirements of the following EEC directives:73/23/EEC and subsequent amendment 93/68/EEC.89/336/EEC and subsequent amendment 92/31/EEC and 93/68/EECand also declares that it is prohibited to put into service the machinery until the machine in which it will be integrated or of which it will become a component has been identified and declared as conforming to the conditions of Directive 98/37/EC.Bologna, 01 January 2005The Managing DirectorA. Bassi3These instructions apply to the following models:402 CBC - 402 SBSThe FAAC 402 automated system for swing leaf gates consists of an enbloc composed of an electric pump and a hydraulic piston which transmits drive to the leaf.The model with a hydraulic locking does not require installation of electric locks, as it guarantees mechanical locking of the leaf when the motor is not operating.The model without a hydraulic locking, requires the installation of electric locks to ensure the leaf is mechanically locked.The 402 automated systems were designed and built to automate swing leaf gates. Do not use for any other purpose.Tab. 1: Technical specifications of “402 Operator”MODEL402 CBC402 SBSPower supply voltage 230 Vac(+6%-10%) 50 (6o) Hz Rod extension speed 1.3 cm/s 1 cm/s Pump flow rate1 l/min 0.75 l/min Traction and thrust force 0-500 daN0-690 daNOperating ambient temperature -40°C - +55°CAbsorbed power 220 W Absorbed current 1 A Motor rotation speed 1400 rpm Motor winding temperature 120°C Weight 6.5 kg Type of oil FAAC HP OILProtection class IP 55Single leaf max length 1,80 m3,00 mUse frequency55 (cycles/hour)4To ensure a correctly operating automated system, the structure of the existing gate or gate to be built must satisfy the following requirements:•Max length of leaves according to the dimensions of Table 1 on page 3.• A strong and rigid leaf structure.•Smooth, uniform leaves movement, without any irregular friction during the entire travel;•Existing hinges in good condition.•Travel limit mechanical stops must be provided.We advise you to carry out the metalwork jobs before installing the automated system.The condition of the structure directly influences the reliability and safety of the automated system.Table A : Recommended dimensions for standard operatorsc = The effective rod stroke is shorter than the maximum stroke, inorder to prevent the rod from reaching its stop point internally, during the opening and closing stages.(*) Rod effective stroke (**) maximum dimension1)Fasten the rear attachment on the pilaster, following the indications in Table A . Modify, if necessary, the length of the supplied attachment.Attention : To avoid compromising good operator functionality, we recommend you to respect the indicated dimensions.• For iron pilasters, accurately weld the rear attachment (ref.ባ, Fig. 6) directly on the pilaster.• For masonry pilasters, select one of the following solutions:A)appropriately lay a walling-in plate and then accurately weld the rear attachment.B)secure, with screws and expansion plugs, the rear attachment plate (ref. a, Fig.6) to the pilaster and then accurately weld the rear attachment to theplate as shown in Fig. 6.If the dimensions indicated in table A or B cannot be executed,the following must be considered in order to determine different measurements:-to obtain 90° opening of the leaf: a + b = c.-to obtain over 90° opening of the leaf: a + b < c.-lower a and b dimensions will result in higher speeds . We advise you to observe the current legal regulations;-limit the difference of the a and b dimensions to within 40 mm :higher differences will considerably vary speed during the opening and closing motion;-for reasons of operator dimensions, the minimum Z dimension is 50 mm (Fig. 4);-if the pilaster dimensions or the position of the hinge (dimension d ) do not make it possible to contain dimension a to the required size, a niche must be made in the pilaster as shown in Opening angle 90°110°a (mm)120100b (mm)120100c(*)(mm)240240d(**)(mm)705056-Lastly, remove the key and restore the power supply to the system.For any repairs, contact FAAC’s authorised Repair Centres.78The following table will help you identify and solve some particular conditions.CONDITIONGate not moving.Gate moving slowly.Gate moving jogwise.The operator is losing oil from the breather screw.The leaves stop at slow-down.Gate speed not constant.A B CD E FSUGGESTION-Check if mains power is supplied.-Make sure that the operator is not unlocked. (chapter 8.).-Check the adjustment of the anti-crushing system (paragraph 4.1).-Check oil level inside the tank. (chapter 9 - Fig. 16).-Check the connection and operation of the thrust capacitor.-Check the efficiency of the electronic control unit.-Check the adjustment of the anti-crushing system (paragraph 4.1).-Make sure that you have removed the breather screw (chapter 5).-Run some complete gate opening and closing cycles, in order to release any air inside the piston.-An initial, minimum oil leak is normal. A larger leak may occur if the operator is not fitted in a perfectly horizontal plane. If the oil leak does not stop soon, weadvise you to visit an authorised repair centre.-Check the adjustment of the anti-crushing system (paragraph 4.1).-Incorrect installation dimensions (paragraph 3.2).Notes919M A I N T E N A N C E R E G I S T E R.o N e t a D b o j f o n o i t p i r c s e D se r u t a n g i S 1_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C 2_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C 3_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C 4_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C 5_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C 6_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C 7_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C 8_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C 9_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C 01_______________________________________________________________________________________________________________________________________na i c i n h c e T re m o t s u C I n s t a l l a t i o n t e c h n i c i a n ________________________________________________C u s t o m e r ___________________________________________________________________T y p e of s y s t e m ________________________________________________________S e r i a l n u m b e r _________________________________________________________I n s t a l l a t i o n d a t e ______________________A c t i v a t i o n ________________________S y s t e m c o n f ig u r a t i o nT R A P L E D O M RE B M U N L A I R E S e r o t a u t t A 402C A A F 1e c i v e d y t e f a S 2e c i v e d y t ef a S 1s l l e c o t o h p f o r i a P 2s l l e c o t o h p f o r i a P 1e c i v e d l o r t n o C 2e c i v e d l o r t n o C lo r t n o c o i d a R pm a l g n i h s a l F ec i v ed re h t O ec i v ed re h t O I n d i c a t i o n of r e s i d u a l r i s k s a n d o f f o r e s e e a b l e i m p r o p e r u s e_________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________Read the instructions carefully before using the product and store them for future useIf correctly installed and used, the 402 automated system ensures a high degree of safety.Some simple rules on behaviour can prevent accidental trouble:-Do not pass between the leaves when they are moving. Waitfor the leaves to open fully before passing through them.-Do not, on any account stay in between the leaves.-Do not stand near the automated system, and do not allowchildren, persons or things to do so, especially when it is operating.-Keep remote controls or other pulse generators away fromchildren, to prevent the automated system from being activated involuntarily.-Do not allow children to play with the automated system.-Do not willingly obstruct leaves movement.-Prevent any branches or shrubs from interfering with leavesmovement.-Keep indicator-lights efficient and easy to see.-Do not attempt to activate the leaves by hand unless you havereleased them.-In the event of malfunctions, release the leaves to allow accessand wait for qualified technical personnel to do the necessary work.-When you have set manual operation mode, cut power to thesystem before restoring normal operation.-Do not in any way modify the components of the automatedsystem.-Do not attempt any kind of repair of direct action whateverand contact qualified personnel only.-At least every six months: arrange a check by qualifiedpersonnel of the automated system, safety devices and earth connection.These instructions apply to the following models:402 CBC - 402 SBS.The FAAC 402 automated system for swing leaf gates consists of a hydraulic enbloc composed of an electric pump and a hydraulic piston which transmits drive to the leaf.The models with a hydraulic locking do not require installation of an electric lock, as they guarantee mechanical locking of the leaf when the motor is not operating.The other models, without a hydraulic locking always require one or more electric locks to ensure the leaf is mechanically locked.Leaves of up to 3 mt can be automated depending on the selected model.The functioning of the operators is controlled by an electronic control unit, housed in an enclosure with adequate degree of protection against atmosphere agents.The leaves are normally closed.When the electronic control unit receives an opening command from the radio control or any other pulse generator, it activates the hydraulic appliance which rotates the leaves until they reach the opening position to allow access.If automatic mode was set, the leaves close automatically after selected pause time has elapsed.If the semi-automatic mode was set, a second pulse must be sent to close the leaf again.A stop pulse (if supplied) always stops movement.For details on the behaviour of the automated system in different function logics, consult the installer.Automated systems include safety devices (photocells) that prevent the leaves from moving when there is an obstacle in the area they protect.The 402 automated system is supplied standard with a hydraulic anti-crush protection safety device (BY-PASS) which limits the torque transmitted to the leaves.The warning-light indicates the current leaf movement.If the gate has to be moved manually due to a power cut or fault of the automated system, use the release device as follows:-Insert the triangular key on the release screw located in the lower part of the flange (Fig.1).-Turn the release key anti-clockwise for about two turns.-Open or close the leaf manually.To prevent an involuntary pulse from activating the operator during the manoeuvre, cut power to the system before re-locking the operator.-To re-lock the operator, turn the key clockwise until it stops (Fig.1).-Release the operator from the front and rear attachments.732143 - Rev. A。

人生的四个阶段

L ife is a bitch. Then you die. So while staring at my navel the other day, I decided that that bitch happens in four stages. Here they are.STAGE ONE: MIMICRYWe are born helpless. We can’t walk, can’t talk, can’t feed ourselves, can’t even do our own damn taxes.As children, the way we’re wired to learn is by watching and mimicking others. First we learn to do physical skills like walk and talk. Then we develop social skills by watching and mimicking our peers around us. Then, finally, in late childhood, we learn to adapt to our culture by observing the rules and norms around us and trying to behave in such a way that is generally considered acceptable by society.The goal of Stage One is to teach us how to function within society so that we can be autonomous, self-sufficient adults. The idea is that the adults in the community around us help us to reach this point through supporting our ability to make decisions and take action ourselves.But some adults and community members around us suck.1They punish us for our independence. They don’t support our decisions. And therefore we don’t develop autonomy. We get stuck in Stage One, endlessly mimicking those around us, endlessly attempting to please all so that we might not be judged.2In a “normal” healthy individual, Stage One will last until late adolescence and early adulthood.3 For some people, it may last further into adulthood. A select few wake up one day at age 45 realizing they’ve never actually lived for themselves and wonder where the hell the years went.This is Stage One. The mimicry. The constant search for approval and validation. The absence of independent thought and personal values.We must be aware of the standards and expectations of those around us. But we must also become strong enough to act in spite of those standards and expectations when we feel it is necessary. We must develop the ability to act by ourselves and for ourselves.STAGE TWO:SELF-DISCOVERYIn Stage One, we learn to fit in with the people and culture around us. Stage Two is about learning what makes us different from the people and culture around us. Stage Two requires us to begin making decisions for ourselves, to test ourselves, and to understand ourselves and what makes us unique.Stage Two involves a lot of trial-and-error and experimentation. We experiment with living in new places, hanging out with new people, imbibing new substances, and playing with new people’s orifices.In my Stage Two, I ran off and visited fifty-something countries. My brother’s Stage Two was diving headfirst into the political system in Washington DC. Everyone’s Stage Two is slightly different because every one of us is slightly different.Stage Two is a process of self-discovery. We try things. Some of them go well. Some of them don’t. The goal is to stick with the ones that go well and move on.Stage Two lasts until we begin to run up against our own limitations. This doesn’t sit well with many people. But despite what Oprah and Deepak Chopra may tell you, discovering your own limitations is a good and healthy thing.You’re just going to be bad at some thin gs, no matter how hard you try. And you need to know what they are. I am not genetically inclined to ever excel at anything athletic whatsoever. It sucked for me to learn that, but I did. I’m also about as capable of feeding myself as an infant drooling applesauce all over the floor. That was important to find out as well. We all must learn what we suck at. And the earlier in our life that we learn it, the better.So we’re just bad at some things. Then there are other things that are great for a while, but begin to have diminishing returns after a few years. Traveling the world is one example. Sexing a ton of people is another. Drinking on a Tuesday night is a third. There are many more. Trust me.Your limitations are important because you must eventually come to the realization that your time on this planet is limited and you should therefore spend it on things that matter most. That means realizing that just because you can do something, doesn’t mean you should do it. That means realizing that just because you like certain people doesn’t mean you should be with them. That means realizing that there are opportunity costs to everything and that you can’t have it all.There are some people who never allow themselves to feel limitations —either because they refuse to admit their failures, or because they delude themselves into believing that their limitations don’t exist. These people get stuck in Stage Two.These are t he “serial entrepreneurs” who are 38 and living with mom and still haven’t made any money after 15 years of trying. These are the “aspiring actors” who are still waiting tables and haven’t done an audition in two years. These are the people who can’t settl e into a long-term relationship because they always have a gnawing feeling that there’s someone better around the corner. These are the people who brush all of their failings aside as “releasing” negativity into the universe or “purging” their baggage from their lives.At some point we all must admit the inevitable: life is short, not all of our dreams can come true, so we should carefully pick and choose what we have the best shot at and commit to it.But people stuck in Stage Two spend most of their time convincing themselves of the opposite. That they are limitless. That they can overcome all. That their life is that of non-stopgrowth and ascendance in the world, while everyone else can clearly see that they are merely running in place.In healthy individuals, Stage Two begins in mid- to late-adolescence and lasts into a person’s mid-20s to mid-30s.4 People who stay in Stage Two beyond that are popularly referred to as those with “Peter Pan Syndrome” —the eternal adolescents, always discovering themselves, but finding nothing.STAGE THREE: COMMITMENTOnce you’ve pushe d your own boundaries and either found your limitations (i.e., athletics, the culinary arts) or found the diminishing returns of certain activities (i.e., partying, video games, masturbation) then you are left with what’s both a) actually important to you, and b) what you’re not terrible at. Now it’s time to make your dent in the world.Stage Three is the great consolidation of one’s life. Out go the friends who are draining you and holding you back. Out gothe activities and hobbies that are a mindless waste of time. Out go the old dreams that are clearly not coming true anytime soon.Then you double down on what you’re best at and what is best to you. You double down on the most important relationships in your life. You double down on a single mission in life, whether that’s to work on the world’s energy crisis or to be a bitching digital artist or to become an expert in brains or have a bunch of snotty, drooling children. Whatever it is, Stage Three is when you get it done.Stage Three is all about maximizing your own potential in this life. It’s all about building your legacy. What will you leave behind when you’re gone? What will people remember you by? Whether that’s a breakthrough study or an amazing new product or an adoring family, Stage Three is about leaving the world a little bit different than the way you found it.Stage Three ends when a combination of two things happen: 1) you feel as though there’s not much else you are able toaccomplish, and 2) you get old and tired and find that you would rather sip martinis and do crossword puzzles all day.In “normal” individuals, Stage Three generally lasts from around 30-ish-years-old until one reaches retirement age.People who get lodged in Stage Three often do so because they don’t know how to let go of their ambition and constant desire for more. This inability to let go of the power and influence they crave counteracts the natural calming effects of time and they will often remain driven and hungry well into their 70s and 80s.5STAGE FOUR: LEGACYPeople arrive into Stage Four having spent somewhere around half a century investing themselves in what they believed was meaningful and important. They did great things, worked hard, earned everything they have, maybe started a family or a charity or a political or cultural revolution or two, and now they’re done. They’ve reached the age where their energy and circumstances no longer allow them to pursue their purpose any further.The goal of Stage Four then becomes not to create a legacy as much as simply making sure that legacy lasts beyond one’s death. This could be something as simple as supporting and advising their (now grown) children and living vicariously through them. It could mean passing on their projects and work to a protégé or apprentice. It could also mean becoming more politically active to maintain their values in a society that they no longer recognize.Stage Four is important psychologically because it makes the ever-growing reality of one’s own mortality more bearable. As humans, we have a deep need to feel as though our lives mean something. This meaning we constantly search for is literally our only psychological defense against theincomprehensibility of this life and the inevitability of our own death.6 To lose that meaning, or to watch it slip away, orto slowly feel as though the world has left you behind, is to stare oblivion in the face and let it consume you willingly.WHAT’S THE POINT?Developing through each subsequent stage of life grants us greater control over our happiness and well-being.7 In Stage One, a person is wholly dependent on other people’s actions and approval to be happy. This is a horrible strategy because other people are unpredictable and unreliable. In Stage Two, one becomes reliant on oneself, but they’re still reliant on external success to be happy — making money, accolades, victory, conquests, etc. These are morecontrollable than other people, but they are still mostly unpredictable in the long-run. Stage Three relies on a handful of relationships and endeavors that proved themselves resilient and worthwhile through Stage Two. These are more reliable. And finally, Stage Four requires we only hold on to what we’ve already accomplished as long as possible.At each subsequent stage, happiness becomes based more on internal, controllable values and less on the externalities of the ever-changing outside world.INTER-STAGE CONFLICTLater stages don’t replace previous stages. They transcend them. Stage Two people still care about social approval. They just care about something more than social approval. Stage 3 people still care about testing their limits. They just care more about the commitments they’ve made. Each stage represents a reshuffling of one’s life priorities. It’s for this reason that when one transitions from one stage to another, one will often experience a fallout in one’s friendships and relationships. If you were Stage Two and all of your friends were Stage Two, and suddenly you settle down, commit and get to work on Stage Three, yet your friends are still Stage Two, there will be a fundamental disconnect between your values and theirs that will be difficult to overcome.Generally speaking, people project their own stage onto everyone else around them. People at Stage One will judge others by their ability to achieve social approval. People at Stage Two will judge others by their ability to push their own boundaries and try new things. People at Stage Three will judge others based on their commitments and what they’re able to achieve. People at Stage Four judge others based on what they stand for and what they’ve chosen to live for.THE VALUE OF TRAUMASelf-development is often portrayed as a rosy, flowery progression from dumbass to enlightenment that involves a lot of joy, prancing in fields of daisies, and high-fiving two thousand people at a seminar you paid way too much to be at.But the truth is that transitions between the life stages are usually triggered by trauma or an extreme negative event in one’s life. A near-death experience. A divorce. A failed friendship or a death of a loved one. Trauma causes us to step back and re-evaluate our deepest motivations and decisions. It allows us to reflect on whether our strategies to pursue happiness are actually working well or not.WHAT GETS US STUCKThe same thing gets us stuck at every stage: a sense of personal inadequacy. People get stuck at Stage One because they always feel as though they are somehow flawed and different from others, so they put all of their effort into conforming into what those around them would like to see. No matter how much they do, they feel as though it is never enough. Stage Two people get stuck because they feel as though they should always be doing more, doing something better, doing something new and exciting, improving at something. But no matter how much they do, they feel as though it is never enough. Stage Three people get stuck because they feel as though they have not generated enough meaningful influence in the world, that they make a greater impact in the specific areas that they have committed themselves to. But no matter how much they do, they feel as though it is never enough.8One could even argue that Stage Four people feel stuck because they feel insecure that their legacy will not last or make any significant impact on the future generations. They cling to it and hold onto it and promote it with every last gasping breath. But they never feel as though it is enough. The solution at each stage is then backwards. To move beyond Stage One, you must accept that you will never be enough for everybody all the time, and therefore you must make decisions for yourself. To move beyond Stage Two, you must accept that you will never be capable of accomplishing everything you can dream and desire, and therefore you must zero in on what matters most and commit to it. To move beyond Stage Three, you must realize that time and energy are limited, and therefore you must refocus your attention to helping others take over the meaningful projects you began. To move beyond Stage Four, you must realize that change is inevitable, and that the influence of one person, no matterhow great, no matter how powerful, no matter how meaningful, will eventually dissipate too. And life will go on.HOW WELL DO YOU REALLY KNOW YOURSELF?We all think we know ourselves well, but psychological studies show otherwise. In fact, most of us are somewhat deluded about ourselves. I put together a 22-page ebook explaining how we can come to know ourselves better, just fill out your email in the form. No spam. I promise.Footnotes1. Often this occurs because the adults/community themselves are still stuck in Stage One.↵ 2. Some people who get stuck in Stage One get stuck because they come to believe that they will never be able to fit in. Thesepeople usually succumb to some form of distraction, depression or addiction.↵ 3. I put normal in quotes because, really, what the fuck is normal?↵ 4. Stages can overlap to a certain extent. Transitioning between them is never black/white. It happens gradually. And often with some emotional stress and major lifestyle changes.↵ 5. This applies to the rare individuals who are talented and capable enough to still remain highly influential and relevant into their 70s and 80s as well. Stage Three doesn’t end until the desire for some peace and quiet outweighs one’s ability to affect change in the world. Some people die without ever leaving Stage Three.↵ 6. 7. For more on this, see The Denial of Death by Ernest Becker.↵ Research shows that generally people become happier and more satisfied as their lives go on.↵ 8. One way to think about it is that people who are stuck at Stage Two always feel as though they need more breadth of experience, whereas Stage Three people get stuck because they always feel as though they need more depth.↵。

英国民事诉讼规则英文

英国民事诉讼规则英文Introduction:The rules of civil litigation in England and Wales are governed by the Civil Procedure Rules (CPR). This comprehensive set of rules and regulations outlines the procedures to be followed in civil court cases in England and Wales.Body:1. Commencement of Proceedings:The CPR sets out the various methods of commencing civil court cases, including issuing a claim form, applying for an injunction, or filing a petition. The claim form must include details of the parties involved, the nature of the claim, and the remedies sought.2. Pleadings:The next stage in the process is pleading, where parties set out their respective positions and arguments in writing. Statements of case include the claimant's particulars of claim, the defendant's defence, and any reply or subsequent pleadings.3. Pre-trial procedures:The parties are required to engage in a range of pre-trial procedures, including disclosure of relevant evidence, the exchange of witness statements, and identifying issues for trial. Case management conferences, interim applications, and pre-trial review hearings are also held at this stage.4. Trial:If the parties still cannot agree on a settlement, the case will proceed to trial. The judge will hear evidence from both parties, examine written submissions, and make a final ruling on the case. Generally, proceedings are held in open court, although some cases may require private hearings.5. Appeals:Either party may appeal the decision of the trial judge if they believe an error was made. The court of appeal will examine the judge's ruling and consider any new evidence before reaching a decision. Further appeals may be made to the Supreme Court.Conclusion:The Civil Procedure Rules provide a clear and structured framework for dealing with civil litigation in England and Wales. They ensure that parties are afforded fair and equal treatment, and that civil court cases are conducted in a timely and efficient manner. By understanding these rules, litigants can navigate the complexities of the English and Welsh legal system with confidence.。

汽车制造--产品各阶段名称解释

1、ET阶段（Engineering Trial，工程调试——设计验证阶段）：在车型开发初期，有设计公司对白车身的精度以及各个空位的精度进行验证和修正的阶段。

典型要求：模具标准化，工艺标准化，零部件与整车结构标准化，品质判定标准化。

2、PT阶段（Production Trial，生产调试——生产验证阶段）：在通过了设计公司的设计验证后，在小批量的生产过程中，对车身的线上可操作性、零件的品质及包装的标准化进行验证和改善阶段。

典型要求：设备与工装夹具到位，人员到位，物料配套到位，生产性达标（工艺直通率、品质保障力与物料批产验证）3、PP (Production Proveout)：预生产——初期量产典型要求：工艺规范化、物流规范化，包装规范化、工位器具规范化、节拍符合设计要求、人员与训练组织到位4、SOP阶段（Start Of Production，小批量生产阶段）：各项验证完成，进入投放市场的小批量生产。

典型要求：按设计节拍实现标准化作业关于ET，PT等缩写的解说1)S-lotS-lot is "Development trial".开发试制Mainly,we will confirm the specification performance.And we will check the quality of the part,too.2)ET-lotET-lot is "Engineering trial".工厂试制Mainly,we will confirm the assembling performance.And we will check the quality of the part,too.3)PT1PT1 is "production trial 1".量产准备1We will confirm all things for production.For exsample)Quolity,Assembling performance,and so on.4)PT2PT2 is "production trial 2".量产准备2This is the final trial stage.If some parts are bad in PT1,we check them in this stage. This is the last confirmation stage before SOP.5)SOPSOP is "Start Of Production"量产开始SOP means "manufacture start".6）SOSSOS is "Start of Sale"销售上市ES指:engineering sample 工程样板EP是指工程设计阶段样板FEP是指确认阶段样板CS：comercial sample 商品试样PP:pre-production or pilot production 预生产或试生产MP:mass production 批量生产DV design verification 设计验证EV engineering verification 工程样品验证PV process verification 小批过程验证。

汽车制造--产品各阶段名称解释

汽车制造--产品各阶段名称解释(共2页)--本页仅作为文档封面，使用时请直接删除即可----内页可以根据需求调整合适字体及大小--1、ET阶段（Engineering Trial，工程调试——设计验证阶段）：在车型开发初期，有设计公司对白车身的精度以及各个空位的精度进行验证和修正的阶段。

典型要求：模具标准化，工艺标准化，零部件与整车结构标准化，品质判定标准化。

典型要求：设备与工装夹具到位，人员到位，物料配套到位，生产性达标（工艺直通率、品质保障力与物料批产验证）3、PP (Production Proveout)：预生产——初期量产典型要求：工艺规范化、物流规范化，包装规范化、工位器具规范化、节拍符合设计要求、人员与训练组织到位4、 SOP阶段（Start Of Production，小批量生产阶段）：各项验证完成，进入投放市场的小批量生产。

典型要求：按设计节拍实现标准化作业关于ET，PT等缩写的解说1)S-lotS-lot is "Development trial".开发试制Mainly,we will confirm the specification performance.And we will check the quality of the part,too.2)ET-lotET-lot is "Engineering trial".工厂试制Mainly,we will confirm the assembling performance.And we will check the quality of the part,too.3)PT1PT1 is "production trial 1".量产准备1We will confirm all things for production.For exsample)Quolity,Assembling performance,and so on.4)PT2PT2 is "production trial 2".量产准备2This is the final trial stage.If some parts are bad in PT1,we check them in this stage. This is the last confirmation stage before SOP.5)SOPSOP is "Start Of Production"量产开始SOP means "manufacture start". 6）SOSSOS is "Start of Sale"销售上市ES指:engineering sample 工程样板EP是指工程设计阶段样板FEP是指确认阶段样板CS：comercial sample 商品试样PP:pre-production or pilot production 预生产或试生产MP:mass production 批量生产DV design verification 设计验证EV engineering verification 工程样品验证PV process verification 小批过程验证。

Community-language-learning

Curran believed that a way to deal with the fears of students is for teachers to become 'language counselors'.
Definition
Community language learning (CLL) was primarily designed for monolingual conversation classes where the teachercounselor would be able to speak the learners' L1(mother tongue).
In this way they are totally involved in the analysis process. The language is completely personalised and with higher levels they can themselves decide what parts of their conversation they would like to analyse, whether it be tenses, lexis or discourse.
Stage 3 - Discussion
Next the students discuss how they think the conversation went. They can discuss how they felt about talking to a microphone and whether they felt more comfortable speaking aloud than they might do normally. This part is not recorded.

CA中英文工艺流程表

1#2#3#4#5#6#7#HNH1H2H3H4H5H6g gmmsKNKNKNResidence Time = Barrel Capacity / Shot Size x Cycle Time 驻留时间=融胶能力÷单啤重量×注塑周期If Residence Time is greater than 7 x cycle time then a stepped temp profile is required 如果驻留时间大于7×周期，那么一个阶梯型的温度分布式必要的。

For T2, T3…Add tabs for additional process sheets 对于T2，T3……请增加表格用于额外的工艺表KPL Process Engineer:KPI Process Engineer:KPL 工艺工程师KPL 工艺工程师KPI-PRC Program Manager:KPI-NA Tooling Engineer:KPL-中国工艺工程师KPL-北美工艺工程师℃℃Speed 速度1st Stage 4th stage Date of Trial ：试作时间：Process Sheet 参数表Keen Point InternationalCustomer 客户：Prepared by ：编写人：Trial Times ：试作次数：Parameters 参数Machine Num. 机台编号Effective date生效期No.of Cavity型腔数量Part Num:品番.：Mold Maker ：制模人Part Name :品名：Mold Number ：模具编号：Program :项目：Approved by ：确认：Resin 材料Grade/Colour 牌号/颜色Machine Type 机台型号Injection 注射Pressure 压力(bar)Position(mm)位置Packing 保压Pressure 压力(bar)Speed 速度(mm/s)time 时间 (s)Screw 储料Pressure 压力(bar)Speed 转速(RPM)Position 位置(mm)2nd Stage 2nd stage 3rd stage 2nd stage 1st stage 1st stage 4th stage4th stage 3rd stage 3rd stage 6th stage 5th stage 5th stagePosition 位置(mm)1st Stage 1st stage 1st stage push 第一段顶出Pressure 压力(bar)Speed 速度Close Mold合模Pressure 压力(bar)Speed 速度Position 位置(mm)Open Mold开模Pressure压力(bar)Speed 速度Position 位置 (mm)Ejection Sys 顶出系统3rd Stage 3rd stage Ejector Stroke 顶出行程2nd Stage 2nd stage 2nd stage push 第二段顶0High pres5th stage1st stage pull 第一段退顶针3#4#5#6#Hot Runner Manifold Temp. 热流道温度Hot Nozzle 热嘴Low pres 4th stage 2nd stage pull 第一段退顶针8#Manifold 流道板1#2#7#8#Thermolator 模温机Cavity 型腔Core 型芯Slide 行位Lifter 斜顶℃℃Actual实际Barrel Temp 螺杆温度Actual 实际Setting 设置℃s Injection time 注射时间Mold Temp.模温Settin g 设置Actual 实际Setting 设置Actual 实际Setting 设置Drying Temp&Time 烤料温度&时间Residence Time 驻留时间 (sec)Barrel Cap (g)融胶能力Shot weight 整啤重量 Cooling time 冷却时间Runner weight 水口重量s Press style 压力方式:Position 位置Time 时间Pressure 压力(bar)TransferV-P 保压切换Clamping force锁模力sCushion 缓冲Low pres 最小压力High pres 最大压力m mCycle time 周期Remark 备注barClamp Data 锁模资料KPI - 331。

[精华]ndsl密室献祭简明攻略

[精华]ndsl密室献祭简明攻略NDSL密室献祭简明攻略胎動* 台阶下的房间1: (场景:台阶) 于画面右下得到改锥【ドライバー】2: (场景:自身) 调查书包、command【?键】执行「查看书包」得到化妆盒【化粧ポーチ】3: 调查化妆盒【化粧ポーチ】、得到发卡【ヘアピン】4: 拉下位于上方的软线5: 用改锥【ドライバー】调查ミキ左侧的地板 6: 对地板下、位于左侧的装置中的小孔使用发卡【ヘアピン】7: 从位于左侧的装置得到某装置【何かの装置】 8: 对右侧的装置、调查水下得到把手【ハンドル】 9: 对左侧的装置中的大孔使用把手【ハンドル】 10: command 执行将软线插入插口「コードをプラグに指す」11: 旋转把手12: 脱出* 走廊1: 调查发光处* 门前1: 调查门右侧的凹槽2: 对凹槽使用发卡【ヘアピン】3: 调查改锥【ドライバー】、与某装置【何かの装置】合体得到打开的电池【開いたバッテリー】4: 对发卡使用打开的电池【開いたバッテリー】==================================================血ミキ編 - stage1* 沙发1: (上半身の画面) 调查....你知道的 (胸口 2: (下半身の画面) 调查....你知道的 (裙下和书包*间壁墙1: (隔壁右側)调查并移走盆栽、打开其下的盖子 2: (隔壁右側)打开拉门拉出消防用软管之后进入洞穴* 空洞1: (空洞1)调查画面左下得到茶色铁板【鉄の板】 2: (空洞2)调查画面右下得到弹簧【バネ】 3: (マンホール裏側)安装刚才得到的【鉄の板】和【バネ】打开盖子==================================================霊アスナ編 - stage1* 三つ並んだ部屋1: (元の部屋) command 移动至「左の部屋」 2: (左の部屋) 调查右侧深处的红光 3: 打开开关、使两个按钮都变蓝 4: command 移动至「右の部屋」 5: (右の部屋) 右侧深处、取下桌上高处的箱子 6: command 移动至「左の部屋」 7: (左の部屋) 按下之前的位于下方的开关、使之变红8: 记下位于控制台上的文字(「П」と「Д」) 8: command 移动至「右の部屋」 9: (右の部屋) 、调查刚才箱子处现在正在发光的墙壁10: 调查控制台并按下(「П」と「Д」)使这两字发光11: command 移动至「左の部屋」 12: (左の部屋) 在控制台按下413: 立刻调查打开的门、前进14: 发现第5个少女「イトカ」==================================================父親オルガ編 - stage1* 父の研究室1: (左侧白色茶几)得到医用胶带【医療用テープ】 2: (右侧黑桌子)得到杯具【ティーカップ】 3: (右侧黑桌子)让【医療用テープ】和【ティーカップ】合体获取指纹4: (右侧黑桌子)对抽屉上的指纹读取器使用获取的指纹5: (抽屉)移开茶色的医学、得到ID Card【，,カード】* 薬品庫1: 在画面中央的密码门上输入741 (注:横向组合2: 调查中央上部的特殊装置使用【，,カード】 3: 输入57085462 (?键查看暗号表，,カード: ICON注:暗号表?:A~EAB70 C08 D35 E23F~J F G19 H66 I57 J91K~O K L46 M31 N62 O54P~T P Q27 R84S48T78U~ U V83 W15 X02Y99=================================================数字クロエ編 - stage1* 医学書の棚1: 调查位于右侧书架、右下方的书* 電力室1: (画面中央)于台阶右侧得到【測定装置】 2: 调查左侧、发现大型机器、再调查左边得到基盘 3: 对基盘左下使用【測定装置】4: 11、53弄红、其他弄蓝 ( wiki无资料..YY:屏幕上显示的数字是那么把11弄红相当于把当前数减绝对值,设蓝红分别表示正和负,22,==================================================夢イトカ編 - stage1* 台阶下的房间1: (场景:左) 得到瘪了的球【しぼんだボール】、并从铁柱中间得到灭火器【消火器】 (吐槽:wiki这里写成了消化器....2: (场景:イトカ) 调查铁管交错的地方、放上【しぼんだボール】3: 对瘪了的球【しぼんだボール】使用灭火去【消火器】* 除去管道后1: (场景:台阶)移走箱子得到图板【パネル】 2: 从下层箱子破了的小孔中得到密码锁的一部分【ダイヤルの欠片】3: (场景:轮椅)解开画面右侧的拼图游戏、并把图板【パネル】嵌入正中4: 调查画面深处写着文字的显示板 (记下顺序ДЬЯВОЛ)(日文wiki这里bug了...场景错误)5: 从轮椅的左车轮下得到密码锁的一部分【ダイヤルの欠片】6: (场景:密码锁)将两个【ダイヤルの欠片】嵌入密码锁7: 按照图版发光文字的顺序依次调为(ДЬЯВОЛ)8: 脱出stage1 clear==================================================stage2友人ミキ編 - stage2* 落下的场所1: (场景:电梯侧) 从左下通风口前的瓦砾中得到扫除机器人【掃除ロボ】2: (场景:充电器侧) 在画面右側充電器给【掃除ロボ】充电3: (场景:电梯侧) 在通风口放置【掃除ロボ】 4: (场景:充电器侧) 调查【掃除ロボ】得到【，,カード】插进充电器里5: (场景:充电器侧) 将【掃除ロボ】装在充电器上并按下画面左侧的上箭头6: (场景:通风口) 在通风口左侧的柱子上使用【掃除ロボ】得到绳子【ロープ】7: (场景:电梯侧) 回收【掃除ロボ】并与【ロープ】组合之后装在柱子上脱出==================================================死アスナ編 - stage2* 垃圾集中地1: (画面:铁桶) 调查铁桶和电线、移开铁桶后再次调查电线2: (画面:铁桶) command 让イトカ按住电线 3: (画面:控制台侧) 按下控制台右侧的两个按钮 4: (画面:铁桶) 从新堆起来的垃圾上面得到【探知機】5: (画面:垃圾再集地2) 在黑色的圆圆的2个垃圾附近使用【探知機】得到锯【のこぎり】6: (画面:门侧) 对门前的木箱使用【のこぎり】得到钥匙【鍵】7: (画面:控制台侧) 使用【鍵】并按下打开的开关* 间壁墙关闭后1: (アスナ侧画面:按钮)按下右侧按钮 2: (イトカ側画面:按钮)按下上下两个按钮、右侧按钮按两次==================================================紅茶オルガ編 - stage2* 公園1: 于喷水池右手前得到空罐【空き缶】 2: (画面:自动贩卖机) 在右侧回收机放入【空き缶】得到硬币【コイン】、并将其放入自动贩卖机得到【紅茶】* 厨房1: (厨房全景) 画面左侧红色橱柜中右数第二个格子、从中得到陶壶【陶器のポッ】2: (厨房里侧) 于画面中央得到水壶【ヤカン】与冰箱上得到茶壶套【ティーコージー】 (茶叶是没用的 3: (厨房里侧) 于画面右下的垃圾箱中得到纸屑【紙くず】使用贴在冰箱的便条下面 (记录泡茶方法;以及密码735 4: (厨房里侧) 于中央靠上右边的厨柜中得到圆形茶碗【丸カップ】5: (厨房里侧) 在画面中央的棕色盒子的密码锁中输入735得到【高級茶葉缶】6: (画面:炉灶) 给【ヤカン】灌满水并在灶台上烧开7: (画面:茶几误) 使用【高級茶葉缶】把高级茶叶放入陶壶中使用【ヤカン】往陶壶和杯具中倒入开水command 倒掉杯具中的水【カップのお湯を捨て】使用【ティーコージー】给陶壶罩上茶壶套command 给杯具中倒入红茶* 寄木細工の箱//寄木细工秘密箱;也称作木片拼花工艺。

尝试的英文短语

尝试的英文短语婴儿成长后，就要开始牙牙学语和走路了。

下面就由店铺为大家带来英语短语集锦，希望大家能有所收获。

关于尝试的相关短语尝试一下 Take a chance ; Take chance ; have a try ; have a bash at尝试错误 trial and error ; Try and Error ; trying error ; attempt mistake尝试阶段 Trial sub stage ; human resources Trial sub stage ; attempt stage继续尝试 You just keep on trying ; Keep trying尝试性 Tentative ; tentatively adv. not definitely or surly尝试教学 Attempt teaching ; attempt teaching ; The attempt teaching ; trial teaching尝试拒绝 try to refuse愿意尝试 Willingness to Try大胆尝试 go for it尝试 have a try关于尝试的相关例句1. An attempt by anti-abortionists to tighten the rules was defeated.反堕胎者所作的加强法规的尝试失败了。

2. I'm always pleased to try out a new variety.我一直乐于尝试新产品。

3. He is always eager for new experiences and ever-willing to experiment.他总是渴望拥有新的经历，而且永远愿意尝试。

4. I tried again to get ahold of my cousin Joan.我再次尝试联系我的表妹琼。

tome4任务攻略

tome4任务攻略本文目录：1、tome4 攻略盾战士怎么加属性2、有没有什么很冷门，但是质量很高的单机游戏呢？3、tome4的游戏简介4、tome4的游戏攻略boss左键点死就是有点慢而且应该解锁什么技能... 比方物免怪你拿把附加元素属性伤害高的武器和盾去... 参考下我的圣骑攻略吧,和盾战玩法差不多的 .有没有什么很冷门，但是质量很高的单机游戏呢？嗯？冷门游戏，质量高，虽然不明确是游戏操作体验高还是要求高画质，不过归类到冷门游戏的话，确实有那么几款游戏可以推荐一下，而且部分操作上具有一定难度，游戏乐趣多多，是值得去体验一下的。

《旋转轮胎：泥泞奔驰》虽然游戏中的名称可能会让玩家产生一种错觉，认为这是一款竞速类游戏，不过恰恰相反，这部是一部“龟速”类游戏了！哈哈~不过比起传统的赛车游戏，也许这款游戏确实要比赛车类游戏要难上几倍了，在操作上。

先来说下这部游戏的玩法，其中有各种各样的载具让玩家驾驶，可以是第一人称视觉，也能够是第三人称视觉，部分硬核玩家为了达成成就，那么就必须是第一人称视觉内完成啦！然而游戏的重点才刚刚开始。

也许在玩家刚接触这款游戏就已经“知错”了，虽然这些车子的样款看起来非常普通，但是它们却能完成一般车没能够完成的任务，也就是在泥泞上行驶，不要以为这只是简单的观看卡车践踏这股泥泞，那你就大错特错了！玩家所行驶的路径，都会随着车辆陷入泥泞的深度而导致车辆是否能够越过这片难以驾驶的地方，更可以说成是被泥泞所侵蚀。

在第一人称视觉中，也许自己驾龄不算高，原以为还能够继续走，谁知道切换成第三人称视觉的时候，则发现车子几乎要泡汤了，特别在于那些拖着长长货物的卡车更是难以驾驶，前进难，倒退难，走泥路更是难上加难！卡车陷入淤泥依然还有救的，那就依靠旁边的树木，利用绳索不断把卡车拉近，让卡车重新进入可行驶区域，另外汽车的档位完全要玩家手动设置，经常在一条路上卡死也是家常便饭了，这一切都要看玩家的操作技术如何啦！《猎人：野性的呼唤》哈哈~在自己体验过这款游戏的时候就已经开始发现，自己的角色没有走几步路，CPU风扇便开始高速转动起来了。

STAGED, BILATERALLY EXPANDABLE TRIAL

申请人：Ouroboros Medical, Inc. 地址：Fremont CA US 国籍：US 更多信息请下载全文后查看
摘要：Systems and methods distracting an intervertebral disc space are provided. The systems use a staged, bilaterally expandable trial. The systems and methods of distracting an intervertebral space are provided in a manner that addresses the problem of subsidence. The method includes inserting the trial into the intervertebral space in a
专利内容由知识产权出版社提供
专利名称：STAGED, BILATERALLY EXPANDABLE TRIAL 发明人：JOHN TO,PRAVEEN GOPAL RAO 申请号：US14 4 804 16 申请日：2014 0908 公开号：US20150073552A1 公开日：20150312 专利附图：
collapsed state and, once inserted, the trial is then used for distracting the intervertebral space using an expansion that includes a first stage and a second stage. The first stage includes expanding the trial laterally toward the peripheral zones of the top vertebral plate and the bottom vertebral plate, and the second stage includes expanding the trial vertically to distract the intervertebral space.

第十届世界肺癌会议英文

➢ The lethal treatment-associated toxicity rate in the chemotherapy arm was 0.8%
Outcome data from IALT
Chemotherapy arm Control
P value
Median survival
50.8 months
➢ 69% of the pts assigned to the chemotherapy arm received all 3 cycles.
➢ Stage Ⅲ disease was present in 28%-29% of pts, while the remainder were stage Ⅰor stage Ⅱ
commentary
➢ NSCLCCG performed a meta-analysis examining the benefit of adjuvant chemotherapy
➢ 17 trials were identified that compared surgery and chemotherapy with surgery alone
Adjuvant lung project ITALY(ALPI)
➢ 1209 pts with completely resected NSCLC were randomly assigned to received either MMC, VDS, and DDP every 3 weeks for 3 cycles or no chemotherapy
Lethal toxicity rate
0.8%
0
The overall survival hazard ratio for chemotherapy was 0.86 95% CI=0.76-0.98 Absolute 5-year survival benefit of 4.1% Absolute 5-year disease-free survival benefit of 5.1%, and hazard ratio was o.83%

审前调查的流程

审前调查的流程Conducting pre-trial investigations is a crucial part of the legal process to ensure that all necessary evidence is gathered before a case goes to trial. 审前调查是法律程序中至关重要的一部分，确保在案件进入审理之前收集到所有必要的证据。

One of the primary goals of a pre-trial investigation is to gather evidence that will help the prosecution build a strong case againstthe defendant. 审前调查的主要目标之一是收集证据，帮助控方构建针对被告的强有力的案件。

The process typically involves the gathering of witness statements, physical evidence, and any other relevant information that may support the prosecution's case. 这个过程通常涉及到收集证人证词、物证，以及任何其他可能支持控方案件的相关信息。

In some cases, the pre-trial investigation may also involve conducting background checks on the defendant, as well as interviewing potential witnesses and conducting surveillance. 在某些情况下，审前调查可能还涉及对被告进行背景调查，以及对潜在证人进行面试和进行监视。

民事诉讼法英语

民事诉讼法英语Civil Procedure Law in EnglishIntroductionIn modern legal systems, the civil procedure law plays a crucial role in governing the process of resolving disputes between individuals or entities. This article aims to provide an overview of the Civil Procedure Law in English, discussing its key principles, stages, and important aspects.I. Overview of Civil Procedure LawCivil Procedure Law, also known as the Law of Civil Proceedings, is a legal framework that governs civil litigation processes and the rights and obligations of parties involved. It serves as a guide for courts and individuals engaged in civil lawsuits. The law ensures fair and efficient resolution of civil disputes and protects the interests of all parties involved.II. Stages of Civil ProcedureThe Civil Procedure Law consists of several stages through which a civil lawsuit progresses. These stages include:1. Filing of LawsuitThe first stage begins with the filing of a lawsuit by the plaintiff, the party initiating the legal action. The plaintiff submits a complaint to the court, providing details of the dispute, claims, and supporting evidence.2. Service of ProcessAfter the lawsuit is filed, the court issues a summons, which is delivered to the defendant by an authorized person. The defendant must acknowledge receipt of the summons within a specified period.3. Pretrial ConferenceIn many jurisdictions, a pretrial conference occurs before the trial. During this stage, the court facilitates communication between the parties and their respective attorneys to identify the key issues in dispute, explore possibilities of settlement, and plan the trial proceedings.4. TrialThe trial stage is when the court examines the evidence, hears arguments from both parties, and makes a judgment based on the law and facts presented. Trials can be conducted by a judge or a jury, depending on the legal system.5. AppealIf either party is dissatisfied with the judgment, they have the right to appeal to a higher court. The appellate court reviews the legal and procedural issues raised by the parties and may uphold, reverse, or modify the lower court's decision.III. Key Principles of Civil Procedure LawThe Civil Procedure Law is guided by several fundamental principles that ensure a fair and just litigation process. These principles include:1. Adversarial SystemCivil litigation follows an adversarial system, where parties to a lawsuit actively contest the issues before an impartial judge. Each party presents their case, introduces evidence, and challenges the other party's arguments.2. Due ProcessThe principle of due process guarantees that all parties have the right to be heard, present evidence, and receive a fair trial by an independent and impartial tribunal. It prevents arbitrary actions and safeguards the rights of individuals involved in civil disputes.3. Burden of ProofIn civil litigation, the burden of proof rests upon the party making the claim. The party asserting a fact or legal right must provide sufficient evidence to convince the court of the validity of their claim.4. Right to Legal RepresentationThe Civil Procedure Law ensures that parties have the right to legal representation. This allows them to seek professional advice, present their case effectively, and understand their legal rights.IV. Important Aspects of Civil Procedure LawApart from the stages and principles, several other important aspects should be considered under Civil Procedure Law:1. JurisdictionJurisdiction determines which court has the authority to hear a particular case. It is based on various factors, such as the subject matter of the dispute, the territorial boundaries, and the amount in controversy.2. Mediation and Alternative Dispute ResolutionMany civil procedure laws encourage parties to explore mediation and alternative dispute resolution methods before going to trial. These methods offer a faster and less adversarial way of resolving disputes, often resulting in mutually acceptable solutions.3. DiscoveryDiscovery is a process through which parties exchange information and evidence before trial. It allows each side to gather relevant facts, documents, and witness testimony. Discovery assists in clarifying the issues, narrowing the scope of the dispute, and facilitating settlement negotiations.4. Execution of JudgmentOnce a judgment is made, the successful party may seek to enforce the decision and obtain the remedies ordered by the court. The Civil Procedure Law provides mechanisms for the execution of judgment, including the seizure of assets, garnishment of wages, or other forms of enforcement.ConclusionIn conclusion, the Civil Procedure Law is a vital element of any legal system, regulating civil litigation processes and ensuring the fair resolution of disputes. Understanding the key principles, stages, and important aspects discussed in this article is essential for individuals and professionals involved in civil lawsuits.。

UterineCancer子宫内膜癌英文

Five histological subtypes --Endometrioid Adenocarcinoma
• Account for about 80~90%.
• Well differentiated.
• Prognosis is better.
Five histological subtypes
--Serous adenocarcinoma
a. Architecture is identical with complex papillary.
b. More aggressively with deep myometrial and lymphatic invasion.
c. Simulating the behavior of ovarian carcinoma.
• Slight enlargement of uterine size and soft
• Uterus fixed, immobile, adenexal mess in advanced stage
Special Examination
Dilation and fractional curettage ( D. C) – Most effective ,definitive procedure and commonly used – Significance -Established correct diagnosis, clinical stage -differentiated from cervical cancer or cervical involvement
• Overall,2%-3% of women develop uterine cancer during their lifetime.

clinic_trial：clinic_trial

Shoskes et al, 2005
Durgaprasad et al, 2005 Holt et al, 2005 Garcea et al, 2005
Ulcerative colitis Improves cogenitive function
2000 mg/day x 180 days -
89 1010
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Phase-I, Randomized
24
Colorectal cancer, ACF 1
Phase-I, Randomized2
-
Colon cancer
Phase-III, Randomized
100
Colorectal cancer, ACF1
Phase-II, Non-randomized
48
Phase 1
500-12,000 mg/day
24
Safe, well-tolerated even at 12 g/day
Lao et al, 2006
Efficacy trials Rheumatoid arthritis Postoperative inflammation External cancerous lesions
Rasyid et al,1999 Lal et al,1999 Heng et al, 2000