Sub-chronic Toxicity of Defoamer Used in Seawater Desalination

Abstract
Objective T o explore the possible long-term health effects of the d e f o a m e r used in seawater
desalination by sub-chronic toxicity testing.
ZHANG Shao Ping1, LI Yi
and LU Kai3>#
1. Institute fo r Environmental Health and Related Product Safety, Chinese Center fo r Disease Control and Prevention, Beijing 100020, China; 2. The Centers fo r Disease Control and Prevention Harbin, Harbin 150000, Heilongjiang, China; 3. Chinese Centerfo r Disease Control and Prevention, Beijing 102206, China
(P < 0.05). T h e direct bilirubin and indirect bilirubin w e r e decreased in the m e d i u m and high dose groups
(P < 0.05). All dose groups s h o w e d significant induction of alkaline phosphatase (P < 0.05). Pathological
examination revealed a case of liver mononuclear cell infiltration in the m e d i u m dose group and three cases of liver congestion, steatosis of hepatic cells around the central vein, a n d punctate necrosis with multiple focal mononuclear cell infiltration in male rats administered the high dose. T h e N o Observed Adverse Effect Level w a s 0.5 g/kg B W in rats, with albumin and total bilirubin as health effect indices.
Conclusion Long-term d e f o a m e r exposure m a y cause liver injury but has n o significant impact o n renal
function in rats. T h e effect o n blood cells in female rats w a s m o r e prominent than that in m a l e rats.
334
Original Article
Sub-chronic Toxicity of Defoamer Used in Seawater Desalination*
Biomed Environ Sci, 2019; 32(5): 334-344
DUAN Lianu&, ZHANG Chong Hua2&, GU Wen1'*, ZHI Hong1, KONG Jian',
Key words: Seawater desalination; Defoamer; Sub-chronic toxicity
Biomed Environ Sci, 2019; 32(5): 334-344
wenku.baidu.com
doi: 10.3967/bes2019.045
ISSN: 0895-3988
www.besjournal.com (full text)_______________ CN: 11-2816/Q_______ Copyright ©2019 by China CPC
INTRODUCTION
Seawater desalination has b e c o m e an important part of industry a n d household water use in countries facing water shortage. China’s seawater desalination industry has b e g u n to take shape a n d is in a stage of rapid
Results The high dose group s h o w e d decreased blood alanine aminotransferase and aspartate aminotransferase (P < 0.05). All doses resulted in a significant increase in albumin and decrease in globulin
Methods Blood analysis, internal organ assessment, a nd histopathological examination w e r e carried
out in rats exposed to low, m e d i u m , a n d high (0.5, 1.0, a n d 2.0 g/kg B W , respectively) doses of d e f o a m e r for 9 0 days through oral administration.