rb1基因表达与突变对乳腺癌患者临床预后的影响

预后，合并RB1基因突变的乳腺癌患者预后较差
【关键词】RB1;乳腺癌；突变；表达水平；临床预后
【中图分类号】R737.9；R446
【文献标志码】A
DOI： 10. 13820/j. cnki. gdyx. 20192150
Effect of RBI gene expression and mutation on the prognosis of breast cancer patients. WEN Yong - qin, XU Yong - qi(ing, HE Jian 一fang、HUANG Hui -jie, ZHU Ying ZHOU Chan , ZHANG Li -jun. Department of Pathology,
Dongguan People's Hospitalt Dongguan 523059, Guangdong, China [Abstract ] Objective To investigate the correlations between RBI expression and clinical features in breast
平显著低于正常癌旁组织，差异有统计学意义(/"()• ()5),RB1低表达的患者其肿瘤最大径M3 cm、淋巴结转
移以及TNM分期为Hl ~ IV期的患者比例均显著高于RB1高表达的患者(P<0. 05) Kaplan - Meier Plotter数
据库结果显示RB1高表达患者的无复发生存率显著优于RB1低表达的患者(P <0.001),而cBioPortal数据
库结果显示RB1基因突变的乳腺癌患者其总体存活率显著低于非突变的患者(P二0.041),Cox多因素模型
分析结果显示乳腺癌患者的TNM分期及RB1表达水平显著影响患者的临床预后(PvO.05)：结论 乳腺癌
RB1表达水平与肿瘤的大小、淋巴结转移及临床预后密切相关，RB1基因高表达显著改善乳腺癌患者的临床
【摘要】 目的 探讨乳腺癌患者组织中KB1基因及蛋白表达与临床特征的关系，并采用生物信息学分
析RB1基因表达与突变对临床预后的影响 方法 选择行手术治疗的乳腺癌患者共250例，采用免疫组化
染色检测癌和癌旁组织中RB1的表达水平，分析RB1表达和临床特征及预后的关系，采用生物信息学分析不
Hale Waihona Puke 同RB1基因表达水平以及RB1基因突变对乳腺癌患者患者预后的影响:结果 乳腺癌组织的RB1表达水
广东医学 2020 年 2 月 第 41 卷第 4 期 Guangdong Medical Journal Feb. 2020, Vol. 41 , No. 4
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RBI基因表达与突变对乳腺癌患者临床预后的 影 * 响
温永琴，徐咏强，何建芳，黄会杰，朱莹，周婵，张丽君
东莞市人民医院病理科(广东东莞523059)
东莞市社会科技发展一般项0201650715x1384温永琴徐咏强何建芳黄会杰朱莹周婵张丽君东莞市人民医院病理科广东东莞523059摘要目的探讨乳腺癌患者组织中kb1基因及蛋白表达与临床特征的关系并采用生物信息学分析rb1基因表达与突变对临床预后的影响方法选择行手术治疗的乳腺癌患者共250例采用免疫组化染色检测癌和癌旁组织中rb1的表达水平分析rb1表达和临床特征及预后的关系采用生物信息学分析不同rb1基因表达水平以及rb1基因突变对乳腺癌患者患者预后的影响
cancer patients, and to analyze the effects of RBI gene expression and mutation on the prognosis. Methods A total of 25() patients with breast cancer received surgery in our hospital from January 2015 to June 2017 were selected. The expres­ sion of Kl)l in cancer and paracancerous tissues was detected by immunohistochemical staining. The coiTelations between Khl expression and clinical features and prognosis was analyzed. The effects of different Rl)l gene expression levels and Rbl genr mutation on the prognosis of breast cancer patients was analyzed. Results The expression level of Rbl in breast cancer tissues was significantly lower than that in normal adjacent tissues ( P V 0. 05 ) . The proportions of patients with tumor size M3 cm, lymph node metastasis and TNM stage HI 一 IV with in low Rbl expression patients were significantly higher than those in patients with high Rbl expression ( P < 0. 05 ). The Kaplan 一 Meier Plotter database showed that the recurrence - free survival rale of patients with high Rbl expression was significantly higher than those with low Rbl expres­ sion (P <0. 001 ). The cBioPortal database showed that the overall sun ival of breast cancer patients with Rbl mutation was significantly lower than that of non - mutant patients (P=0. 041 ). Cox multivariate model analysis showed that TNM stage and Rbl expression level in breast cancer patients significantly affected the prognosis of patients ( P < 0. 05 ) . Con­ clusion The expression of Rbl in breast cancer is closely correlated to tumor size, lymph node metastasis and clinical prognosis. The high expression of Rbl gene significantly improves the prognosis. The prognosis of breast cancer patients with Rbl gene mutation is poor.