老年慢性阻塞性肺疾病患者血清瘦素水平与炎症及胰岛素抵抗的研究

老年慢性阻塞性肺疾病患者血清瘦素水平与炎症及胰岛素抵抗
的研究
田银君;刘前桂;赵黎;李金红;赵双燕
【期刊名称】《实用老年医学》
【年(卷),期】2011(25)3
【摘要】目的分析老年慢性阻塞性肺疾病(COPD)患者血清瘦素水平与C反应蛋白(CRP)、空腹血糖HFBG)、胰岛素抵抗及体质量指数(BMI)的关系.方法选取住院的老年COPD患者60例,按病程分为急性加重期和临床稳定期,在不同时期测定空腹血清瘦素、CRP、FBG、胰岛素(FINS)、动脉血氧分压(PaO2),测量身高、体质量,计算BMI、胰岛素抵抗指数(HOMA-IR).选择同期健康老年人50例作为对照.结果 (1) COPD急性加重期血清瘦素、CRP、FBG、FINS、HOMA-IR均显著高于临床稳定期及对照组(P＜0.01).(2) COPD临床稳定期FINS和HOMA-IR显著高于对照组(P＜0.05).(3) 各组中瘦素与FBG、FINS、HOMA-IR、BMI均呈显著正相关(P＜0.05或P＜ 0.01);在急性加重期,瘦素还与CRP呈显著正相关(P＜0.01),均衡FBG、FINS、HOMA-IR、BMI后进行偏相关分析,瘦素与CRP的相关性不再显著(P＞0.05).结论老年COPD急性加重期患者血清瘦素、CRP水平升高并伴一定的胰岛素抵抗,瘦素与CRP、FBG、胰岛素抵抗及BMI存在一定的相关性,瘦素可能参与COPD急性加重期的炎症反应.%Objective To explore the relationship of serum leptin level with C-reactive protein (CRP), fasting blood
glucose( FBG), insulin resistance (IR), and body mass index (BMI) in geriatric patients with chronic obstructive pulmonary disease(COPD). Methods Totally 60 elderly COPD patients were enrolled, according to
their course of disease, and were divided into acute exacerbation and clinical stable phase according to the condition. Serum leptin, CRP,FBG, fasting insulin (FINS) , and arterial partial pressure of oxygen (PaO2 ) were determined, height and weight were measured, and BMI and homeostasis model assessment of insulin resistance index (HOMA-IR) were calculated in different course of COPD disease period. At the same time, 50 healthy geriatric subjects served as controls. Results ① Serum leptin, CRP, FBG, FINS,and HOMA-IR in acute exacerbation of COPD group were significantly higher than those in clinical stable phase group and control group(P ＜0. O1 ). ② FINS and HOMA-IR in clinical stable phase group were significantly higher than those in control group( P ＜0. 05 ). ③ Serum leptin were positively correlated with FBG, FINS, HOMAIR, and BMI in the two
groups( P ＜ 0. 05 or P ＜ 0. 01 ), serum leptin was positively correlated with CRP in acute exacerbation of COPD group, while except for the influential factors such as FBG, FINS, HOMA-IR and BMI, serum leptin had no correlation with CRP( P ＞ 0. 05 ). Conclusions Serum leptin and CRP concentrations are increased in acute exacerbation of geriatric COPD patients, and these patients are followed by IR. There are correlations between serum leptin and CRP, FBG, IR and BMI. Leptin may be involved in the inflammatory reaction of acute exacerbation of COPD patients.
【总页数】4页(P230-232,235)
【作者】田银君;刘前桂;赵黎;李金红;赵双燕
【作者单位】100095,北京市,北京老年医院呼吸康复科;100095,北京市,北京老年医院呼吸康复科;100095,北京市,北京老年医院呼吸康复科;100095,北京市,北京老年医院呼吸康复科;100095,北京市,北京老年医院呼吸康复科
【正文语种】中文
【中图分类】R563
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