N末端-前B型钠尿肽水平动态变化对重症监护室患者死亡的预测价值

N末端-前B型钠尿肽水平动态变化对重症监护室患者死亡的
预测价值
张宝秋;宋其生;史剑权;吴恩东
【期刊名称】《中国医药导报》
【年(卷),期】2015(000)002
【摘要】目的：研究N末端-前B型钠尿肽(NT-proBNP)水平动态变化对重症监
护病房(ICU)患者死亡的预测价值。

方法回顾性分析首都医科大学附属北京胸科医
院ICU的58例死亡患者的临床资料，连续监测这些患者各个时间段NT-proBNP 的数值，分析NT-proBNP及其变化值对患者预后的判断价值。

用COX回归方法研究NT-proBNP及NT-proBNP变化值与死亡的相关性。

结果NT-proBNP 24、NT-proBNP 48 d、NT-proBNPmin与生存时间明显相关(P<0.05)，OR值结果
分别为1.205(95%CI：1.201~1.208)、1.303(95%CI：1.298~1.307)、
0.896(95%CI：0.893~0.898)。

结论NT-proBNP 24、NT-proBNP 48 d、NT-proBNPmin可能是ICU患者死亡的预测因素，NT-proBNP 24、NT-proBNP 48 d与病死率呈正相关，NT-proBNPmin与病死率呈负相关。

但是NT-proBNP结
果必须结合临床环境来应用和解释，如何在更多混杂因素的环境下研究NT-proBNP对ICU患者预后的影响仍然需要更多的进一步研究。

%Objective To investigate the prognostic value of NT-proBNP and the change in NT-proBNP level in the dead cases with different kinds of diseases. Methods Clinical data of 58 non-survivors conducted in the ICU of Beijing Chest Hospital, Capital Medical University were retrospectively analyzed, the level of NT-proBNP and the change of NT-proBNP in different stage were
measured and recorded. Diagnostic performances of NT-proBNP and the change of NT-proBNP were analyzed. The correlation between NT-proBNP, change of NT-proBNP and the survival time were tested using COX regression test. Results NT-proBNP 24, NT-proBNP 48, NT-proBNPmin were correlated with survival time and the correlation remained statistically significant using COX regression analysis (P < 0.05) ,the OR value of which were 1.205 (95%CI: 1.201-1.208), 1.303 (95%CI: 1.298-1.307), 0.896 (95%CI: 0.893-0.898) respectively. Conclusion NT-proBNP 24, NT-proBNP 48 d, NT-proBNPmin measured during ICU can act as a predictor for mortality in ICU. The measurements of NT-proBNP 24 and NT-proBNP 48 d are positive correlation with mortality, NT-proB-NPmin are negative correlation with mortality. However, the results should not be used in isolation from the clinical con-text. Further research is required to unravel the significance of elevated BNP levels in different confounding factors.
【总页数】5页(P94-97,102)
【作者】张宝秋;宋其生;史剑权;吴恩东
【作者单位】首都医科大学附属北京胸科医院检验科，北京 101149;辽宁省大连市结核病医院结核科，辽宁大连 116033;首都医科大学附属北京胸科医院ICU，北京 101149;首都医科大学附属北京胸科医院ICU，北京 101149
【正文语种】中文
【中图分类】R743
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