NUCLEAR MEDICINE AND ITS RELEVANCE TO THE SHROUD OF TURIN
全新版大学英语综合教程2(第二版)UNIT3课后语句翻译
Text AProfessor Hawking thinks it important to keep everybody in touch withwhat science is about. In this article he explains why.霍金教授认为使每个人都了解科学是干什么的非常重要。
在这篇文章中,他对其中的缘由作了解释。
Public Attitudes Toward ScienceStephen Hawking1 Whether we like it or not, the world we live in has changed a greatdeal in the last hundred years, and it is likely to change even more inthe next hundred. Some people would like to stop these changes and go backto what they see as a purer and simpler age. But as history shows, thepast was not that wonderful. It was not so bad for a privileged minority,though even they had to do without modern medicine, and childbirth washighly risky for women. But for the vast majority of the population, lifewas nasty, brutish, and short.公众科学观斯蒂芬·霍金无论我们是否愿意,我们生活的世界在过去一百年间已经变化了许多,而且在未来的一百年里可能变化更多。
Nuclear Medicine
核医学Definition:1.核医学:用放射性核素诊断、治疗疾病和进行医学研究的医学科目。
2.同位素:具有相同质子数但具有不同中子数,在化学元素排在同一位置。
3.核素:是原子核的属性,原子核的质子数、中子数和原子核所处的能量状态完全相同的原子集合成为核素。
4.稳定性核素:原子核中,当核内中子数和质子数保持一定比例时,核力与斥力平衡不致发生核内成分或能态变化,这类核素称为稳定性核素。
5.放射性核素:原子核内质子或中子过多,都会使原子核失去稳定性,称为不稳定核素,又称放射性核素。
6.核衰变:不稳定核素通过自发性内部结构或能态调整使其稳定的过程。
与此同时,它将释放一种或一种以上的射线,这种性质称为放射性。
7.α衰变:是核衰变时放出α离子的衰变,主要发生在Z>82的核素。
8.β衰变:是核衰变时释放出β射线或俘获轨道电子的衰变,包括β+衰变,β-衰变和电子俘获三种形式。
9.γ衰变:是指核素由高能态向低能态、或激发态向基态跃迁过程中放射出γ射线或称单光子的衰变。
10.衰变定律:衰变过程中初始母核数的减少遵循指数函数的规律,其表达式为N=No*e^-λt。
11.半衰期(物理半衰期):某一放射性核素在衰变过程中,原有的放射性活度减少至一半所需要的时间称为T1/2。
放射性活度:单位时间内发生核衰变的次数,国际单位为贝可,定义为每秒发生一次核衰变。
12.生物半衰期:指进入生物体内的放射性活度经由各种途径从体内排出原来一半所需要的时间。
Tb13.有效半衰期:指生物体内的放射性活度由从体内排出和物理衰变双重作用,在体内减少为原来一半所需要的时间。
Teff14.SPECT:单光子发射型计算机断层显像仪。
PET:正电子发射型计算机断层显像仪。
15.放射免疫分析法:是建立在放射性分析的高度灵敏性和免疫反应的高度特异性的基础上,通过测定放射性标记抗原-抗体复合体的量来计算出待测抗原(样品)的量。
16.热结节:结节部位放射性分布高于正常甲状腺组织,有时仅结节显影而正常组织不显影,多见于功能性甲状腺腺瘤和结节性甲状腺肿。
核能在医疗上的应用英语作文
核能在医疗上的应用英语作文The Application of Nuclear Energy in Medical Fields.The advancements in technology and science have revolutionized various sectors, and healthcare is no exception. One such remarkable technology that has found its way into medical practice is nuclear energy. Nuclear energy, although primarily associated with its controversial use in power generation, has numerous beneficial applications in medicine, particularly in diagnostics and therapeutics.Diagnostic Applications of Nuclear Energy in Medicine.1. Radioisotope Scanning: Radioisotopes, which emit radiation, are used in scanning techniques like positron emission tomography (PET) and single-photon emission computed tomography (SPECT). These scans provide detailed images of the internal structures of the body, especially the brain, heart, and other organs. Radioisotopes attachedto specific molecules can be used to target specific tissues or organs, allowing doctors to identify abnormalities or diseases.2. Magnetic Resonance Imaging (MRI): Although MRI does not directly use nuclear energy, it relies on the nuclear properties of hydrogen atoms to create detailed images of the body. The strong magnetic field and radiofrequency pulses cause the protons in hydrogen atoms to align and then relax, emitting radio waves that are captured by the scanner to create images.3. Computed Tomography (CT) Scans: CT scans use x-rays, which are a form of electromagnetic radiation. The scanner rotates around the patient, taking multiple x-ray images from different angles. These images are then combined by a computer to create cross-sectional images of the body.Therapeutic Applications of Nuclear Energy in Medicine.1. Radiotherapy: Radiotherapy, or radiation therapy, isa common treatment for cancer. High-energy radiation, suchas x-rays or gamma rays, is used to destroy cancer cells or slow their growth. This therapy can be external, where the radiation is delivered from a machine outside the body, or internal, where radioactive materials are inserted into the body close to the tumor.2. Radiopharmaceuticals: Radioactive substances can be used to treat certain diseases. For example, radioactive iodine is used to treat thyroid cancer by destroying the thyroid tissue and cancer cells that absorb the iodine. Similarly, radioactive phosphorus can be used to treat bone cancers.3. Brachytherapy: This is a type of radiotherapy where radioactive sources are placed directly into or near a tumor. The radiation emitted destroys the cancer cellswhile minimizing damage to surrounding healthy tissue. Brachytherapy is commonly used to treat prostate cancer, cervical cancer, and skin cancer.Advantages and Challenges of Nuclear Energy in Medicine.Advantages:High Precision: Nuclear medicine techniques allow doctors to target specific areas of the body, reducing collateral damage to healthy tissue.Early Detection: Diagnostic techniques like PET and SPECT can detect diseases in their early stages, improving treatment outcomes.Non-Invasive: Many nuclear medicine procedures are non-invasive, reducing the risk of infections and other complications.Challenges:Radiation Safety: The use of radiation in medical procedures raises concerns about patient and staff safety. Strict safety protocols must be followed to minimize radiation exposure.Cost: Nuclear medicine procedures can be expensive,limiting their accessibility in resource-limited settings.Disposal of Radioactive Materials: The disposal of radioactive materials used in these procedures requires special handling and care to prevent environmental contamination.In conclusion, nuclear energy has found numerous applications in the medical field, from diagnostics to therapeutics. Its precision and effectiveness in treating diseases like cancer make it an invaluable tool in modern healthcare. However, the associated risks and costs must be carefully managed to ensure the safe and effective use of nuclear energy in medicine.。
核医学绪论 医学影像学 放射诊断学 华中科技大学同济医学院
Tongji Medical College Huazhong University ofScience & Technology Introduction张永学核医学Nuclear Medicine •Definition•Content•Nuclear Medicine and medical development•History review and present situationDefinition核医学是一门研究核技术在医学中的应用及其理论的学科。
它是核物理学、电子学、化学、生物学、计算机技术等学科与医学相结合的产物,是和平利用原子能的一个重要方面。
实验核医学Experimental Nuclear Medicine•Radionuclide tracing technique 示踪•Radionuclide dynamic analysis 动力学•In vitro radioassay 体外放射分析•Radioautography and activation analysis 放射自显影术与活化分析技术等。
•其任务是研究医学领域的疑难问题,发展、创立新的诊疗技术和方法,推动临床核医学的发展。
•实验核医学相当于外科学的解剖和生理学,为正确应用核技术提供理论基础。
临床核医学Clinical Nuclear Medicine•是利用核医学的各种原理、技术和方法来研究疾病的发生、发展,研究机体的病理生理、生物化学和功能结构的变化,达到探讨病因和诊治疾病的目的。
•临床核医学是核医学的重要部分,随着学科的发展,临床核医学又逐步形成了系统核医学,如核心脏病学、核内分泌学、神经系核医学等,它反映了核医学的成熟过程与发展。
核医学在医学中的作用Nuclear medicine and medicine developing•通过核素示踪技术,可以在生理状态下,从分子水平动态地研究机体各种物质的代谢变化,细致地揭示了体内及细胞内代谢的内幕,这是其它技术难以实现的。
共核医学英语知识语料
共核医学英语知识语料Nuclear medicine is a fascinating field that uses radioactive substances to diagnose and treat diseases. It's like having a superpower to see inside the body without surgery.Doctors use nuclear medicine scans to get a detailed picture of organs and tissues. It's like taking a high-definition photo of the inside of your body. Theradioactive tracers used are specially designed to attach to certain cells or molecules.The idea of having radioactive material in your body might sound scary, but the doses used in nuclear medicine are tiny and safe. The benefits of getting an accurate diagnosis or targeted treatment far outweigh any potential risks.One of the coolest things about nuclear medicine is how it can be used to treat cancer. Radioactive particles canbe injected directly into a tumor, killing the cancer cells while minimizing damage to healthy tissue. It's a precision approach to medicine.And did you know that nuclear medicine can also be used to track the progress of a disease over time? By administering the same tracer repeatedly, doctors can see how the disease is responding to treatment and make adjustments accordingly.In summary, nuclear medicine is a powerful tool in the fight against disease. It's not just about diagnosing problems; it's about finding targeted solutions and monitoring progress. It's the future of personalized healthcare.。
化学干细胞学综述
A
DOI: 10.1021/jm500838d J. Med. Chem. XXXX, XXX, XXX−XXX
Journal of Medicinal Chemistry Particular attention will be paid to testing protocols involving phenotypic screening and model organisms. These enable the discovery of active molecules both from lead structures with defined pharmacology and by high-throughput screening of large compound libraries. The modification of these active compounds by conventional medicinal chemistry techniques to maximize the potency and selectivity of candidate compounds will be discussed and, where appropriate, the leading “proof-ofprinciple” compounds presented. While there have been many examples of drug approvals from phenotypic screening campaigns, there can be challenges in translating candidate compounds to the clinic where the molecular target, or off-target effects, may be unknown. It is clear from the multiple studies described that the detailed investigation of the mechanisms of action of these compounds will produce valuable information on the critical signaling pathways in the cells and present further targets for drug discovery; examples of these will be discussed. More detailed investigations of the pharmacological actions of significant compounds in a wide range of cell and tissue types may be used to give a detailed picture of their overall biological activity, tissue specificity, and safety profile before the undertaking of clinical studies. Thus, through the use of key examples, this perspective will pay particular attention to: (a) documenting what is already known about molecules acting on these cell systems; (b) reviewing the state of the art for initial screening protocols which have the potential to be used to discover active compounds by both traditional and high-throughput assays; (c) describing the more detailed studies necessary on key compounds before human use could be envisaged; (d) describing such compounds which have been used in the clinic. The concept of stimulating stem cells in situ is an emerging approach in regenerative medicine, and a few examples of candidate drugs operating through this mechanism have been reported and reviewed.4,5 Recently Hoffman and Metternich have used the term “molecular organ repair”6 to describe the processes whereby small molecules are able to trigger cellular self-renewal mechanisms or celomatic stem cells. Further, Poss has discussed tissue regeneration and pointed out that many mammalian tissues, including cardiac muscle, spinal cord, and the major appendages, appear to have very little regenerative capacity.7 He also pointed out that stem cells are not always involved even in the well-established regenerative processes. Indeed, the example par excellence of limb regeneration, namely the salamander, appears to use predominantly a process of dedifferentiation rather than stem cell differentiation. Further, in the mammalian heart, multiple potential candidate cell types have been identified. However, there appears to be more promise in targeting resident progenitor cells of developmental origin which contribute multiple cell types to the developing heart for cardiac regeneration as opposed to the rare adult-only resident cardiac “stem cells”.8 While the objective of these studies is obviously to find in vivo active molecules and several pioneering examples have been described in recent years, the majority of the work disclosed to date has come from in vitro studies. Nonetheless, these systems represent useful in vitro models and selected examples will be discussed in this context. The comparatively
cecil medicine
Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession医学方法,病人和医疗专业:医学学会和人道的职业Approach to MedicineMedicine is a profession that incorporates science and the scientific method with the art of being a physician. The art of tending to the sick is as old as humanity itself. Even in modern times, the art of caring and comforting, guided by millennia of common sense as well as a more recent, systematic approach to medical ethics (Chapter 2), remains the cornerstone of medicine. Without these humanistic qualities, the application of the modern science of medicine is suboptimal, ineffective, or even detrimental医学是一种职业,包含了科学和科学方法的艺术做一个医生。
照顾病人的艺术作为人类本身一样古老。
即使在现代,艺术的关心和安慰,由几千年的常识以及最近的一个,系统方法对医学伦理学(第2章),仍然是医学的基石。
如果没有这些人文素质,现代医学科学的应用是次优的,无效的,甚至是有害的The caregivers of ancient times and premodern cultures tried a variety of interventions to help the afflicted. Some of their potions contained what are now known to be active ingredients that form the basis for proven medications (Chapter 28). Others (Chapter 38) have persisted into the present era despite a lack of convincing evidence. Modern medicine should not dismiss the possibility that these unproven approaches may be helpful; instead, it should adopt a guiding principle that all interventions, whether traditional or newly developed, can be tested vigorously, with the expectation that any beneficial effects can be explored further to determine their scientific basis.古代和近代文化的护理人员尝试了各种干预措施帮助受苦。
表观遗传与环境
REVIEW PAPEREnvironmental epigenetics:prospects for studying epigenetic mediation of exposure–response relationshipsVictoria K.Cortessis •Duncan C.Thomas •A.Joan Levine •Carrie V.Breton •Thomas M.Mack •Kimberly D.Siegmund •Robert W.Haile •Peter irdReceived:21February 2012/Accepted:7June 2012/Published online:28June 2012ÓThe Author(s)2012.This article is published with open access at Abstract Changes in epigenetic marks such as DNA methylation and histone acetylation are associated with a broad range of disease traits,including cancer,asthma,metabolic disorders,and various reproductive conditions.It seems plausible that changes in epigenetic state may be induced by environmental exposures such as malnutrition,tobacco smoke,air pollutants,metals,organic chemicals,other sources of oxidative stress,and the microbiome,particularly if the exposure occurs during key periods of development.Thus,epigenetic changes could represent an important pathway by which environmental factors influ-ence disease risks,both within individuals and across generations.We discuss some of the challenges in studyingepigenetic mediation of pathogenesis and describe some unique opportunities for exploring these phenomena.Abbreviations ART Assisted reproductive technologies ASM Allele-specific DNA methylation ChIP Chromatin immunoprecipitation CIMP CpG island methylator phenotype CpG Cytosine-phosphate-guanine dinucleotide CRC Colorectal cancer DES Diethylstilbestrol feNO Fractional exhaled nitric oxide FFPE Formalin-fixed paraffin-embedded HDAC Histone deacetylases iNOS Inducible nitric oxide synthase IUGR Intra-uterine growth restriction IVF In vitro fertilizationPBMCs Peripheral blood mononuclear cells PTS Maternal smoking during pregnancy SNP Single nucleotide polymorphismBackgroundThe field of epigenetics grew from attempts,beginning over 70years ago,to understand mechanisms whereby multiple cellular phenotypes arise from a single genotype during the complex process of developmental morpho-genesis termed epigenesis.The term ‘‘epigenetics’’was initially reserved for mechanisms by which phenotypic state,as determined by differential gene expression,could be stably retained through cell division by non-genetic factors.Various mechanisms have been proposed to have the potential to encode this phenotypic information;these include enzymatic methylation of cytosine bases (DNAV.K.Cortessis and D.C.Thomas contributed equally to this work.V.K.Cortessis ÁA.J.Levine ÁT.M.Mack ÁR.W.HaileDepartment of Preventive Medicine,Keck School of Medicine,University of Southern California,USC Norris Comprehensive Cancer Center,1441Eastlake Avenue,Los Angeles,CA 90089,USA D.C.Thomas (&)Department of Preventive Medicine,Keck School of Medicine,University of Southern California,2001N.Soto St.,SSB-202F,Los Angeles,CA 90089-9234,USA e-mail:dthomas@C.V.Breton ÁK.D.SiegmundDepartment of Preventive Medicine,Keck School of Medicine,University of Southern California,2001N.Soto St.,Los Angeles,CA 90089-9234,USAirdDepartments of Surgery,Biochemistry and Molecular Biology,Keck School of Medicine,University of Southern California,USC Norris Comprehensive Cancer Center,Epigenome Center,1441Eastlake Avenue,Los Angeles,CA 90089-9601,USAHum Genet (2012)131:1565–1589DOI 10.1007/s00439-012-1189-8methylation),post-translational modification of tail domains of histone proteins(histone modifications)and associated nucleosome positioning or chromatin remodel-ing,non-coding RNAs,and transcription factor regulatory networks(Ptashne2007).Epigenetic marks established by each of these processes are often shared within a cell lineage; however,whether all persisting epigenetic marks satisfy requirements for stable transmission through cell division or some are merely reestablished from other information fol-lowing mitosis remains a vigorously debated question.The term epigenetics has more recently been used in the scientific literature to describe various unspecified non-genetic mechanisms influencing phenotype.This broader usage emerged from mouse studies addressing transgen-erational nutritional effects on phenotype,as well as human studies of phenotypic differences between monozygotic twins.In the popular press‘‘epigenetics’’has become almost synonymous with nutritional and environmental influences on gene expression.Thus,while‘‘epigenetics’’initially referred to largely self-contained developmental processes,it has come to describe environmental influences on phenotypic readout of genotypes.This semantic evo-lution has caused confusion and controversy regarding the meaning of‘‘epigenetics’’at a time of intensified interest in the possible role of epigenetic mechanisms in disease.In this review we define as epigenetic processes those that stably affect gene expression through mechanisms not involving the primary nucleotide sequence,and epigenetic state as the configuration of chromatin and DNA marks utilized by these processes.By contrast,genetic state is widely understood to refer to the primary nucleotide sequence itself,while genetic processes maintain or change nucleotide sequence.Epidemiologic research addressing epigenetic mecha-nisms as mediators of environmental exposures on disease risk is constrained by important ethical considerations. These often preclude both experimental exposure to candi-date environmental causes,and invasive collection of cell types of greatest developmental and functional relevance to disease processes.Inquiry has therefore progressed largely by integrating information about biological mechanisms obtained in model systems with observational data provided by humans.To address the current state and future promise of this research,we undertook this review with two goals:to illustrate the potential of epigenetic processes to mediate exposure–phenotype relationships and to discuss study design and statistical analysis methods needed to investigate such mechanisms in relation to origins of human disease.We begin by discussing genetic,developmental,and environ-mental determinants of epigenetic state in human and model systems,then describe some of the diverse data implicating epigenetic mechanisms in various human diseases,both within individuals and across generations.We conclude by discussing technical challenges,suggesting promising opportunities for epidemiologic research in environmental epigenetics,and offering some thoughts about translational significance and future directions of thisfield. Determinants of epigenetic stateEpigenetic mechanisms work in concert to influence the potential for gene expression at myriad locations through-out the genome.The resulting epigenetic state of the gen-ome,termed epigenome,varies by cell type.Considering the tremendous diversity of epigenetic marks,which include dozens of different post-translational histone modifications and more than50million sites of potential DNA methylation in a diploid human genome(and thus [250M possible epigenotypes!),it seems that no two human cells would have identical epigenomes.Indeed,within each individual there are many epigenomes,and these change over time as a consequence of both normal developmental and pathological processes,as well as environmental exposures and random drift.Despite this potential for considerable variability of epigenetic patterns within and between individuals,there can also be remarkable consis-tency.In a study of11tissues in6autopsies,DNA meth-ylation patterns in a highly selected set of loci were found to be highly conserved,with intraclass correlations of0.85 across tissues within individuals and0.83across individ-uals within tissues(Byun et al.2009).The authors inter-preted these patterns as revealing different sets of person-specific and tissue-specific differentially methylated genes, anticipating subsequently observed differential genetic and acquired determination(Waterland et al.2010).DNA methylation has been the epigenetic mark most extensively measured in epidemiologic research for numerous reasons.It is of fundamental biological interest owing to its unambiguously stable transmission during cell division.It also has practical advantages:as a chemically stable covalent change to the DNA itself,DNA methylation is the only epi-genetic mark that survives the DNA extraction and purifica-tion that is routine in molecular sample processing,and it can endure decades of archival sample storage(Kristensen et al. 2009).Genetic influencesNucleotide sequence is a primary determinant of epigenetic state,clearly evident from the distribution of epigenetic marks across the genome,determined in part by direct effects of G:C content and CpG(cytosine-phosphate-guanine dinucleotide) density(Tanay et al.2007;Thomson et al.2010).Additional genetic influences include proximity to repetitive elements such as Alu and LINE1(Estecio et al.2010),nucleararchitecture(Berman et al.2011),and binding sequences for transacting proteins(Bell et al.2011b;Weth and Renkawitz 2011).Motif searches and screening strategies have identified sequence elements that predispose to particular epigenetic states(Feltus et al.2006;Ideraabdullah et al.2011;Keshet et al.2006;Lienert et al.2011).Several lines of evidence indicate that genetic poly-morphisms can affect epigenetic state.Greater differences were observed between dizygotic co-twins than between monozygotic co-twins in two forms of epigenetic state: skewed patterns of X-inactivation,and DNA methylation at differentially methylated regions of the imprinted IGF2/ AH19locus(Wong et al.2011;Heijmans et al.2007; Ollikainen et al.2010).Extensive DNA methylation anal-yses in a multigenerational family revealed that epiallelic similarity was greater amongfirst-degree relatives than among more distantly related family members.In the same study,analyses addressing both genetic variation and DNA methylation identified widespread occurrence of allele-specific DNA methylation(ASM)that was associated with polymorphic nucleotides located near the DNA methyla-tion site,but not parent of origin.Authors of this report concluded that the majority of such ASM events depend on cis-acting DNA sequence(Gertz et al.2011).Such ASM events have yet to be characterized in large population-based studies,but more modest studies addressing hetero-zygous non-imprinted loci have identified widespread ASMs associated with nearby genotypic polymorphisms in DNA from multiple tissue types(Kerkel et al.2008;Tycko 2010;Schalkwyk et al.2010),as well as allele-specific chromatin structure and transcription factor binding in lymphoblastoid cell DNA(McDaniell et al.2010,reviewed in Birney et al.2010).Presumed transgenerational inheri-tance of epigenetic changes(‘‘epimutations’’)in the MLH1 (Suter et al.2004)and MSH2(Chan et al.2006)mismatch repair genes,both associated with colorectal cancer,were also traced to germline genetic variation.In the case of the MSH2 epimutation,deletion of a gene immediately upstream of the MSH2gene causes transcription to run through the MSH2 promoter,causing somatic hypermethylation and gene silencing(Ligtenberg et al.2009).The MLH1epimutation was found to be caused by a polymorphism in the50UTR of the MLH1gene,reducing transcriptional activity,and pre-disposing to aberrant somatic DNA methylation in each generation(Hitchins et al.2011).Developmental programming of the epigenomeIn successful mammalian reproduction,the single-cell zygote gives rise to an organism with hundreds of cell types.These diverse cellular phenotypes arise from the same shared genomic sequence by control of the subset of genes expressed in each cell type.Cellular differentiation is tightly linked to extensive erasure and establishment of lineage-specific epi-genetic marks,a process termed epigenetic reprogramming. Relatively detailed descriptions of DNA methylation in developing tissues have been carried out in the mouse,which serves as a model of epigenetic reprogramming in mammalian development(Trasler2009).At fertilization,reprogramming begins with extensive erasure of methyl marks in DNA of the paternal(sperm-derived)DNA,followed by more general loss of methyl marks in the zygote and embryo during cleavage divisions,while sparing parent-of-origin specific imprints.By the blastocyst stage,de novo DNA methylation distinguishes inner cell mass cells(from which embryonic lineages arise to create fetal structures)from relatively hypomethylated trophectoderm cells(from which extra-embryonic lineages arise to create transient structures,including placenta)(Fig.1).Germ cell lineage specification begins in cells of the proximal epiblast,and involves a second extensive erasure of DNA methylation that removes parental imprint marks (Fig.1).Thereafter,the germ line develops in a sexually dimorphic fashion.New DNA methyl marks are established over many stages,extending through sexual maturity in accordance with the sex of the developing individual.At this time,the sex-specific imprint marks that govern parent-of-origin specific expression of imprinted genes in the sub-sequent generation are established(Faulk and Dolinoy2011).Developmental reprogramming can result in dramatic epigenetic differences between the two alleles.The asso-ciation between mono-allelic gene expression and DNA methylation has long been recognized,both in the context of X-inactivation in females(Boggs et al.2002;Sharp et al. 2011)and in parent-of-origin determined genomic imprinting(Ferguson-Smith2011),but now also in the mono-allelic expression of non-imprinted autosomal loci (Harris et al.2010;Tarutani and Takayama2011).Further resetting of epigenetic marks accompanies differ-entiation of many specialized cell types of the body as well as placenta and other transient structures during pregnancy,and subsequent development of body structures during various postnatal stages of development.Chromatin states that arise during development can affect the propensity to subsequent epigenetic change.An example of this is the predisposition of polycomb-repressive complex occupied genes in stem cells to the acquisition of DNA methylation abnormalities in aging and cancer(Ohm et al.2007;Schlesinger et al.2007; Teschendorff et al.2010;Widschwendter et al.2007).Environmental influencesMultiple differences in gene expression,presumably reflecting intrauterine epigenetic differences,have been identified in several tissues from newborn identical twins (Gordon et al.2011).The global methylation pattern ofindividuals changes with increasing age (Bjornsson et al.2008),as does the difference in global methylation between MZ twin pairs (Fraga et al.2005).Genetically identical MZ twins show some epigenetic discordance at birth,as indi-cated by gene expression discordance (Gordon et al.2011).Even over the first decade of life (Wong et al.2010),and as aging adults (Talens et al.2010),MZ twins acquire addi-tional differences in epigenetic state,which may partly reflect different exposure histories,as would be expected if environmental exposures influence epigenetic state.How-ever,stochastic drift in epigenetic state and related con-sequences such as mono-allelic expression described in the previous section is likely responsible for much of the observed divergence.Therefore,other forms of data (dis-cussed below)are needed to determine what type of exposures may influence epigenetic state and the extent of resulting changes.Experimental studiesThe most direct evidence suggesting that ambient exposures may influence epigenetic state is experimental.In vitro studies have demonstrated associations of DNA methylation with various metals (Dolinoy et al.2007b ;Wright and Baccarelli 2007).In the in vivo setting,prenatal protein restriction is associated with hypomethylation of the gluco-corticoid receptor (GR )and PPAR a gene promoter regions inrat liver (Lillycrop et al.2005),changes that were prevented by folic acid supplementation (Lillycrop et al.2005)and which were transmitted to the F2generation (Burdge et al.2007).Plagemann et al.(2009)found hypermethylation in the promoter of the anorexigenic gene for proopiomelano-cortin in rats overfed as neonates.Whether this change could be transmitted to offspring was not assessed.DNA from sperm of mice exposed to steel plant air was found to be persistently hypermethylated long after exposure ended (Yauk et al.2008).Additionally,maternal nurturing behav-ior has been shown to modify methylation at individual CpG sites in the ngf1a binding region of the GR gene in the hip-pocampus of the offspring (Weaver et al.2004),an epige-netic modification that persisted both into adulthood to modify response to stress,and into the F2generation.Human studiesChristensen and Marsit (2011)and Terry et al.(2011)have provided comprehensive reviews of environmental influ-ences on epigenetic state in humans.Here we note expo-sure periods of particular interest and several examples of environmental exposures reportedly associated with epi-genetic state of specific human cell types.The epigenome may be most vulnerable to environ-mental insults during periods of extensive epigenetic reprogramming,which may in theory be disruptedbyFig.1Reprogramming ofDNA methylation in the zygote,early embryo,and primordial germ cells.Thickness of the outer arrows indicates levels of DNA methylation.Red maternal genome,blue paternal genome,black diploid genome.Embryonic lineages arise from cells of the inner cell mass (ICM),the placenta and extraembryonic membranes from trophectoderm cells,and the germ cell lineage fromprimordial germ cells following their determination fromproximal epiblast.Inner circles indicate developmental stages when key elements ofepigenetic programming are thought to occur (Adapted from Feng et al.2010)exposures that interfere with any process that governs reprogramming.Periods of particular vulnerability may therefore include the early stages of embryonic develop-ment mentioned above.Childhood is also proposed as a period of vulnerability,especially in the germline of females,since oocytes remain in a haploid de-methylated state until puberty,so environmental insults may poten-tially disturb the epigenetic state of the oocyte for many years(Faulk and Dolinoy2011),with potential implica-tions for both fertility and initial epigenetic state of off-spring of an exposed female.Somatic changes to DNA methylation may also result from environmental exposures in adults,as have been observed in aging and disease processes such as cancer described in the next section. Energy and nutrient intakeSignificant epigenetic changes in the IGF2gene have been documented in those prenatally exposed to severe caloric restriction during the Dutch hunger winter of World War II (Heijmans et al.2008).Hughes et al.(2009)additionally found that those most likely to be exposed to this famine during adolescence or young adulthood had a significantly decreased risk of developing colorectal cancers(CRC) characterized by the CpG island methylator phenotype (CIMP),suggesting a role for early life exposures in CIMP-specific CRC pathogenesis.Folates are the major source of the methyl groups used for DNA and histone methylation.One study of folates and other one-carbon nutrients reported a differential effect of folate on the risk of the CIMP CRC subset compared to the non-CIMP subset(Van Guelpen et al.2010),while two other studies did not(Slattery et al.2006;van den Donk et al.2007).Most studies of the microsatellite instability high subset,characterized by hypermethylation of the MLH1gene promoter region and CIMP(Weisenberger et al.2006),have yielded similarly negative results(Eaton et al.2005;Schernhammer et al.2008;Slattery et al.2001; Wark et al.2005).On the other hand,in some studies the association between intake of alcohol(which degrades folates)and CRC risk has been reported to be greater in MSI-H and CIMP tumors(Diergaarde et al.2003;Eaton et al.2005;Slattery et al.2001).Micro-RNAs(miRNAs)are very short non-coding RNA molecules that can downregulate protein-coding genes by destabilizing mRNAs or blocking translation.The possi-bility that exogenous microRNA consumed in food may epigenetically regulate gene expression has emerged from recent studies demonstrating the presence of plant-derived miRNAs in sera of humans and other mammals(Zhang et al.2012).One of these plant microRNAs,MIR168a, which was demonstrated to be only of plant origin in control mice,binds coding sequence of the mammalian LDLRAP1 gene in vitro.Functional consequences in mammalian sys-tems were demonstrated experimentally,as MIR168a administered in vitro and during in vivo feeding studies decreased expression of the protein product of LDLRAP1. This line of research suggests novel epigenetic mechanisms whereby diet may modify risk of human disease.Air pollutionEmerging evidence suggests that air pollutants can influ-ence epigenetic changes,including DNA methylation as well as up-or down-regulation of miRNAs(Jardim2011). In human epidemiologic studies,PM2.5and PM10expo-sures are associated with hypomethylation of Alu and/or LINE1elements in leukocytes and buccal cells(Baccarelli et al.2009;Bollati and Baccarelli2010;Madrigano et al. 2011;Salam et al.2012;Tarantini et al.2009),as well as altered DNA methylation in NOS2A,a gene involved in production of nitric oxide(Salam et al.2012;Tarantini et al.2009).Living in highly polluted cities(high PM and ozone)is also associated with hypermethylation of FOXP3 in regulatory T cells(Nadeau et al.2010),while neonates who were prenatally exposed to polyaromatic hydrocarbon (PAH)had hypermethylated ACSL3in DNA of umbilical cord white blood cells(Perera et al.2009);notably,both of these genes are involved in asthma pathogenesis.PAHs are also associated with hypermethylation of LINE1and Alu (Pavanello et al.2009;Perera et al.2009).More limited evidence is emerging to suggest that air pollution is asso-ciated with changes in miRNA expression(Bollati et al. 2010;Jardim2011),and adverse effects of air pollution constituents may be modified by variant alleles of genes involved in miRNA processing(Wilker et al.2010). Tobacco smokeFetal exposure to maternal smoking during pregnancy (PTS)is associated with reduced methylation of several repeated sequences,including Sat2(Flom et al.2011),Alu, and LINE1among children with the GSTM1null genotype (Breton et al.2009).PTS exposure is also associated with increased DNA methylation in specific genes,such as AXL and PTPRO(Breton et al.2009,2011b)and IGF2(Murphy et al.2011).In adult lung cancer patients,quantity and duration of active smoking as well as second-hand smoke is associated with increased DNA methylation of p16(Kim et al.2001;Scesnaite et al.2012),MGMT,and DAPK (Russo et al.2005).Tobacco smoke is also associated with tumor cell DNA methylation changes in esophageal squa-mous cell carcinoma(Huang et al.2011),significantly higher frequencies of abnormal DNA hypermethylation inprostate(Enokida et al.2006)and gastric cancers tumor cells(Nan et al.2005)and with a higher risk of CIMP?colorectal tumors(Limsui et al.2010;Samowitz et al.2006).Lastly,the F2RL3gene is hypomethylated in smokers and may mediate the detrimental impact of smoking on cardiovascular mortality,since hypomethylat-ed F2RL3was found to be strongly associated with car-diovascular mortality among patients with stable coronary heart disease(Breitling et al.2012).Oxidative stressReactive oxygen species(ROS)are involved in numerous cellular processes including cellular redox alterations, immune response,signaling pathways,chromatin remod-eling and gene expression(Sundar et al.2010).ROS have the potential to influence epigenetic mechanisms(Baccar-elli and Bollati2009),and have been shown to inhibit binding of methyl-CpG binding protein2,a critical epi-genetic regulator that recruits cytosine methyl transferases and histone deacetylases to DNA(Valinluck et al.2004). Numerous environmental exposures,including constituents of air pollution and tobacco smoke,can generate ROS and thus may potentially alter epigenetic processes through oxidative stress mechanisms.MetalsPrenatal lead exposure is associated with decreased meth-ylation of LINE1and Alu in cord blood(Pilsner et al. 2009),and a similar pattern of LINE1methylation was reported in an elderly cohort(Wright et al.2010).Studies in humans have shown that arsenic exposure is associated with either global hypermethylation or hypomethylation in peripheral blood mononuclear cells(PBMCs)depending on dose(Majumdar et al.2010),as well as DNA hyperme-thylation of several genes,including CDKN2A(Chanda et al.2006),RASSF1A and PRSS3(Marsit et al.2006). Exposure to airborne particulates rich in lead,cadmium and chromium are associated with miRNA expression in peripheral blood(Bollati et al.2010)and airborne levels of nickel and arsenic are positively correlated with both his-tone3-lysine4trimethylation(H3K4me3)and histone 3-lysine9acetylation(H3K9ac)in blood leukocytes (Cantone et al.2011).Occupational exposure to nickel is associated with increased H3K4me3and decreased H3K9me2in PBMCs(Arita et al.2011).Lastly,cadmium can induce overexpression of the DNA methyltransferase genes DNMT1and DNMT3a in human embryo lung fibroblasts,and is associated with hypermethylation and silencing of the MSH2,ERCC1,XRCC1and OGG1genes in human bronchial epithelial cells(Jiang et al.2008;Zhou et al.2011).Organic chemicalsGas-station attendants and police officers occupationally exposed to low levels of benzene were found to have significantly lower LINE1and Alu methylation,hyper-methylation of p15,and hypomethylation of MAGE-1in blood(Bollati and Baccarelli2010;Bollati et al.2007).Genetic9epigenetic9environmental interactionsMost work investigating effects of environmental factors on epigenetic state has not considered the potential for genetic susceptibility to modify these associations.However,Salam et al.(2012)recently investigated contributions of both genetic and epigenetic variation in air pollution-mediated levels of fractional exhaled nitric oxide(feNO).Measure-ment of feNO provides an in vivo summary assessment of inducible nitric oxide synthase(iNOS)activity as well as airway inflammation.These investigators found interrelated effects of exposure to the air pollution constituents PM2.5, NOS2A promoter haplotypes,and methylation of the iNOS encoding gene NOS2A and NOS2promotor haplotypes on feNO level.These observations illustrate not only the feasi-bility of assessing interactions between epigenetic,genetic, and environmental factors,but also the importance of doing so in order to delineate complex biological relationships and identify susceptible subpopulations.Epigenetic effects in human diseaseConditions associated with improper parental contributions of imprinted genes are currently the clearest examples of human diseases related to epigenetic state.Even before genomic imprinting was described,experiments in which pronuclei were transplanted into enucleated eggs demon-strated that both maternal and paternal chromosomal con-tributions are required for normal development.Control conceptuses receiving one set(haploid genome)of mater-nal(egg-derived)and one set of paternal(sperm-derived) chromosomes could develop normally.However,abnormal development and early demise occurred in all conceptuses receiving either two maternal sets or two paternal sets of chromosomes(McGrath and Solter1984),which devel-oped into tissues with histologic features of dermoid cysts and hydatiform moles,respectively.Model imprinting disorders such as Beckwith–Wiede-mann,Angelman,Russell–Silver,and Prader–Willi syn-dromes are human conditions that can be caused by aberrant epigenetic state(Ferguson-Smith2011).The specific features,early onset,and rarity of these disorders facilitated recognition of their relation to improper parental contributions of imprinted loci(e.g.two maternal or two。
诊疗一体化在核医学领域的研究进展
国际医学放射学杂志InternationalJournalofMedicalRadiology2021Mar 鸦44穴2雪:207-211诊疗一体化在核医学领域的研究进展宋爽唐立钧*【摘要】核医学中的诊疗一体化是指将放射性核素显像和内放射治疗相结合。
目前针对生长抑素受体、前列腺特异性膜抗原、CXC 族趋化因子受体4和纤维母细胞活化蛋白等不同靶点已研发出多种化合物,将用于显像和治疗的核素分别标记于上述化合物后可实现多种肿瘤的诊疗一体化。
核素显像是指导治疗方案的基础,也是内放射治疗的必要前提。
诊疗一体化在肿瘤的诊断、分级与分期、治疗、疗效监测及预后判断等过程中起着重要作用,是实现肿瘤个体化医疗的关键。
就上述靶点的诊疗一体化在核医学领域的研究进展予以综述。
【关键词】诊疗一体化;生长抑素受体;前列腺特异性膜抗原;趋化因子受体;纤维母细胞活化蛋白;正电子发射体层成像;放射性核素治疗中图分类号:R73;R445.5文献标志码:AThe research progress of theranostics in the field of nuclear medicine SONG Shuang,TANG Lijun.Department ofNuclear Medicine,First Affiliated Hospital with Nanjing Medical University,Nanjing 210009,China.Corresponding author:TANG Lijun,E-mail:******************.cn【Abstract 】Theranostics in nuclear medicine refers to the combination of radionuclide imaging and internalradiotherapy.At present,various compounds have been developed for different targets such as somatostatin receptor,prostate specific membrane antigen,C -X -C chemokine receptor 4,fibroblast activated protein.Radionuclides for imaging and treatment can be used to label above compounds respectively,which can achieve the theranostics of multiple tumors.Imaging is the basis for guiding treatment regimens,and is also a necessary prerequisite for internal radiotherapy.Therapeutic diagnos is play an important role in tumor diagnosis,grading,staging,treatment efficacy monitoring and prognosis judgment.This is the key to therealization of personalized medical treatment.This review summarizes the research progress of the theranostics of these targets in the field of nuclear medicine.【Keywords 】Theranostics;Somatostatin receptor;Prostate specific membrane antigen;Chemokine receptor;Fibroblast activated protein;Positron emission tomography;Radionuclide therapyIntJMedRadiol,2021,44(2):207-211作者单位:南京医科大学第一附属医院核医学科,南京210009通信作者:唐立钧,E-mail:******************.cn *审校者基金项目:江苏省医学重点人才基金项目(ZDRCB2016003)DOI:10.19300/j.2021.Z18317在个体化医疗时代,诊疗一体化具有重要的地位。
核医学大纲必背单词
核医学大纲必背单词核医学Nuclear medicine 原子atom 电子electron质子proto 中子neutron 核子nucleon质量数mass number 同位素isotope 同质异能素isomer核素nuclide 放射性核素radionuclide 放射性衰变radiation decay正电子positron 电子俘获衰变electron capture 特征X射线characteristic X ray俄歇电子Auger electrons 同质异能跃迁isomeric transition 放射性活度radioactivity物理半衰期physical half life 生物半衰期biological half life 有效半衰期effective half life放射性活度radioactivity 比活度specific radioactivity 放射性浓度radioactivity concentration 电离作用ionization 激发作用excitation 散射作用scattering韧致辐射bremsstrahlung 吸收作用absorption 光电效应photoelectric effect康普顿效应Compton effect 电子对形成electron pair production单电子发射计算机断层仪single photon emission computed tomography,SPECT正电子发射计算机断层仪Positron emission tomography,PETX线透射式计算机断层显像Transmission computed tomography,TCT放射性探测Radiation detection 电离探测仪ionization detector 闪烁探测仪scintillation detector准直器Collimator 晶体crystal 光电倍增管photomultiplier tube 符合探测coincidence detection湮灭annihilation 放射性药物radiopharmaceuticals 显像剂imaging agent失踪剂tracer 核反应堆nuclear reactor 回旋加速器cyclotron放射性核素发生器Radionuclide generator 质量控制quality control比活度specific activity 放射性核纯度radionuclide purity放射化学纯度radiochemical purity 静态显像static imaging 动态显像dynamic imaging感兴趣区Region of interesting,ROI 局部显像regional imaging 全身显像whole body imaging早期显像early imaging 延迟显像delay imaging 断层显像section imaging/tomography 阳性显像Positive imaging 阴性显像negative imaging 静息显像rest imaging负荷显像stress imaging 介入显像interventional imaging放射免疫分析radioimmuno assay,RIA 免疫放射分析immunoradiometric assay亲和力affinity 特异性specificity 滴度titer受体放射配基结合分析radioligand binding assay,RBA 配体ligand激动剂agonist 拮抗剂antagonist 可饱和性saturability高亲和力High affinity 可逆性reversibility 识别能力recognition化学发光免疫分析chemiluminescence immunoassay分子核医学molecular nuclear medicine代谢显像metabolism imaging 受体显像receptor imaging 反义显像antisense imaging凋亡显像apoptosis imaging 脑血流显像cerebral blood flow imaging脑代谢显像cerebral metabolic imaging 脑神经递质和受体显像neurotransmitter and neuroreceptor imaging放射性核素脑血管显像radionuclide cerebral angiographic imaging交叉性小脑失联络crossed cerebellar diaschisis 过度灌注luxury perfusion脑氧代谢率cerebral metabolic rate of oxygen,CMRO2氧吸收分数oxygen extraction fraction,OEF脑葡萄糖代谢率cerebral metabolic rate of glucose,CMRGlu甲状腺摄131I率131I thyroid uptake rate 甲状腺激素抑制试验thyroid hormone suppression test甲状腺兴奋试验thyroid stimulation test 过氯酸钾释放试验potassium perchlorate washout test高功能结节hyperfunctioning nodule 低功能结节hypofunctionging nodule温结节warm nodule 冷结节cold nodule甲状腺血流显像thyroid blood flow imaging 甲状腺阳性显像thyroid positive imaging甲状旁腺显像parathyroid imaging 肾上腺髓质显像adrenal medulla imaging心血管核医学cardiovascular nuclear medicine 心肌灌注显像myocardial perfusion imaging可逆性缺血reversible ischemia 固定缺损fixed defect反向再分布reverse redistribution 感兴趣区region of interest,ROI极坐标靶心图分析polar Bull’s eye analysis平衡门电路心室显像法gated ventricular imaging局部室壁运动regional wall motion 时相分析phase analysis心脏负荷或介入试验cardiac stress or interventional test心肌活性myocardial viability 冬眠hibernating顿抑stunning 亲心肌梗死显像infarct-avid imaging胃肠道出血显像gastrointestinal bleeding imaging 异位胃黏膜ectopic gastric mucosa胃排空功能测定gastric emptying study 胃—食管反流测定gastroesophageal reflux十二指肠—胃反流显像duodenogastric reflux study 唾液腺显像salivary gland imaging肝胆显像hepatobiliary dynamic imaging 肝脾显像colloid liver-spleen imaging肝动脉血流灌注和血池显像liver artery perfusion and blood pool imaging肝肿瘤阳性显像positive imaging of liver tumors肺部通气显像pulmonary ventilation imaging 肺灌注显像pulmonary perfusion imaging放射性核素骨显像radionuclide bone imaging 超级骨显像super bone imaging“闪耀”现象flare phenomenon “炸面圈”征doughnut sign骨动态显像dynamic bone imaging 骨矿含量bone mineral content,BMC骨密度bone mineral density,BMD 骨髓显像bone marrow imaging再生障碍性贫血aplastic anemia 淋巴显像lymphatic imaging放射性肾图radioactive renography 肾脏指数renal index ,RI肾功能介入试验kidney function intervention test 利尿试验diuresis test巯甲丙脯酸试验captopril test 肾动态显像renal static imaging肾静态显像renal static imaging 放射性核素膀胱显像radionuclide cystography膀胱反流显像countercurrent cystography 肿瘤受体显像receptor imaging肿瘤前哨淋巴结sentinel lymphnode,SLN 传能线密度linear energy transfer,LFT作用容积volume of interaction 甲亢hyperthyroidism毒性弥漫性甲状腺肿toxic diffuse goiter,Graves disease甲状腺危像thyroid storm 功能自主性甲状腺结节autonomous function thyroid nodule,AFTN 分化型甲状腺癌differentiated thyroid carcinoma,DTC 肾上腺素能肿瘤adrenergic tumors嗜铬细胞瘤pheochromocytoma 神经母细胞瘤neuroblastoma介入核医学interventional nuclear medicine 放射性核素介入治疗radionuclide interventional therapy放射性胶体腔内介入治疗intracavitary interventional therapy放射性粒子radioactive seed 辐射防护radiation protection照射量exposure dose,X 吸收剂量absorbed dose,D当量剂量equivalent dose H 射线生物效应biological effects确定性效应determinate effect 随即效应stochastic effect传能线密度linear energy transfer,LET 相对生物效应relative biological effectiveness,RBE屏蔽shield。
核药合成 书籍
核药合成书籍
以下是一些关于核药合成的推荐书籍:
1. 《核医学与分子成像导论》(Introduction to Nuclear Medicine and Molecular Imaging)- by Chongzhao Ran, Xiaoyuan Chen
这本书提供了核医学和分子成像领域的基础知识,并介绍了核药物的合成和应用。
2. 《放射性药物化学与制剂学》(Radiopharmaceutical Chemistry and Drug Development)- by P. J. H. Scott 这本书讲述了放射性药物的化学合成、制备和临床应用,包括核药物的合成方法和质控原理。
3. 《核医学与分子影像学临床实践指南》(Clinical Nuclear Medicine and Molecular Imaging)- by Ralph Weissleder, Johannes Czernin, Mukesh MGH Harisinghani 这本书介绍了核医学和分子影像学在临床诊断中的应用,包括核药物的合成、成像技术和临床应用。
这些书籍都可以帮助你深入了解核药合成的原理、方法
和应用,适合从事核药合成研究或相关领域的学习者阅读。
孝亲敬老英语作文初二
孝亲敬老英语作文初二Title: Embracing the Time-Honored Virtue of Filial Piety and Respect for the Elderly: A Cultural Tapestry in English Language ArtIn the rich tapestry of human virtues, filial piety and respect for the elderly stand as testaments to the enduring value of intergenerational harmony and reverence. This essay explores the profound cultural significance and contemporary relevance of these traditions, drawing parallels with Western philosophies and illuminating the universal appeal of nurturing familial bonds.The ancient wisdom embedded in Confucian teachings elegantly encapsulates the essence of filial piety—the notion that honoring one's parents and ancestors is the bedrock of societal morality and order. This ethos, deeply rooted in Eastern cultures, particularly in China, resonates with similar tenets found in Western philosophies like the principle of "justice as fairness" espoused by John Rawls, which emphasizes respect and fairness in societal interactions. The echoes of such shared ideals across disparate cultures underscore the global importance of these values.Delving into historical narratives, one finds myriadexamples of individuals who embodied these ideals. Stories like that of Emperor Wen of Han, who personally tasted his mother’s medicine to ensure its safety, reflect an unwavering commitment to care and respect. These historical personages serve as beacons, guiding contemporary society towards the virtue of filial devotion.In the modern era, despite the churn of digital advancements and globalization, the core principles of filial piety and respect for elders remain relevant. In an age where nuclear families are becoming increasingly common, the role of these traditions in fostering family cohesion cannot be overstated. They provide a framework for transmitting values, knowledge, and experiences from one generation to the next, ensuring the continuity of familial and cultural heritage.Moreover, the application of these virtues extends beyond familial confines, advocating for a broader societal respect that mirrors the dignity and deference afforded to elders. In nursing homes and community settings, initiatives that encourage interaction between youths and the elderly not only bridge the generational divide but also enrich the lives of all involved parties. Such programs exemplify the practical manifestation of these traditions in a modern context,promoting mutual understanding and respect.In conclusion, the traditions of filial piety and respect for the elderly offer timeless wisdom that transcends cultural boundaries. They epitomize respect, compassion, and intergenerational solidarity—values that are as vital today as they were centuries ago. As we navigate the complexities of modern life, let us continue to weave these golden threads into the fabric of our societies, fostering harmonious relationships that enrich us all.Through this exploration, it becomes evident that the principles of filial piety and respect for the elderly are not antiquated concepts but living legacies that hold immense transformative power. By embracing these virtues, we not only pay homage to our ancestors but also sow the seeds for a future where respect and compassion are the cornerstones of societal interactions.。
Radiology-Introduction Of Nuclear Medicine
Medicine
Nuclear Medicine
Basic NM
Clinic NM
immunology
Biology
Gene Imaging Antisense Imaging Receptor Imaging Targeted therapy
Radioimmunoassay RIA Imaging Radioimmunotherapy
Positron
18F 15O 11C others
Radiopharmaceuticals (tracer) and characteristics
Diagnostic & therapeutic Basic requirements of physical & biological properties
It uses very small amounts of radioactive materials or radiopharmaceuticals to diagnose and treat diseases.
Radiopharmaceuticals are substances that are attracted to specific organs, bones, tissues or cells.
Clinical indications
Cerebrovascular disease: stroke, infarction, hemorrhage; other perfusion deficiency.
Epilepsy Tumors Dementia Brain Death Assessment
RNA-DNA reverse transcriptase, The genetic code, Cholesterol Synthesis and metabolism, Cell Cycle Cell membrane receptor
bioengineering and translational medicine简介
bioengineering and translationalmedicine简介Bioengineering and translational medicine are two rapidly evolving fields that have the potential to revolutionize healthcare and improve patient outcomes.Bioengineering, also known as biomedical engineering, is the application of engineering principles and techniques to biology and medicine. It involves the development and design of medical devices, diagnostic tools, and therapies that aim to solve healthcare challenges. Bioengineers work on a wide range of projects, such as creatingartificial organs, designing prosthetic limbs, and developing drug delivery systems.Translational medicine, on the other hand, focuses on bridging the gap between scientific research and clinical practice. It involves the translation of laboratory discoveries into practical applications that can be used to diagnose, treat, and prevent diseases. Translational medicine aims to shorten the time it takes for scientific breakthroughs to reach patients and improve their health outcomes.The field of bioengineering and translational medicine is characterized by collaboration between scientists, engineers, clinicians, and industry professionals. This multidisciplinary approach allows for the development of innovative solutions to healthcare problems. For example, bioengineers may collaborate with medical doctors to design anew medical device that can improve patient outcomes or work with pharmaceutical companies to develop new drug delivery systems.One of the major challenges in bioengineering and translational medicine is ensuring the safety and efficacy of new technologies and therapies. Before a new medical device or therapy can be approved for clinical use, it must undergo rigorous testing to ensure its safety and effectiveness. This process, known as regulatory approval, involves conducting preclinical studies in the laboratory and then testing the device or therapy in clinical trials with human subjects. The results of these studies are carefully evaluated by regulatory agencies, such as the Food and Drug Administration (FDA) in the United States, before a product can be brought to market.The field of bioengineering and translational medicine has already made significant advancements in healthcare. For example, the development of artificial organs and prosthetic limbs has greatly improved the quality of life for individuals with organ failure or limb loss. Additionally, the use of advanced imaging techniques and diagnostic tools has allowed for earlier and more accurate diagnosis of diseases, leading to improved treatment outcomes.Looking to the future, bioengineering and translational medicine hold great promise for personalized medicine. Personalized medicine involves tailoring medical treatment to an individual's unique genetic makeup, lifestyle, and environment. Advances in bioengineering and translational medicine are driving the development of new technologies that can analyze an individual's genetic profile and provide targeted therapies based on their specific needs. This approach has the potentialto revolutionize healthcare by providing more precise and effective treatments.In conclusion, bioengineering and translational medicine are rapidly evolving fields that have the potential to revolutionize healthcare and improve patient outcomes. The collaboration between scientists, engineers, clinicians, and industry professionals is driving innovation and the development of new technologies and therapies. While there are challenges to overcome, the advancements made in these fields have already had a significant impact on healthcare and hold great promisefor the future.。
核医学nuclearmedicine
• “Good” Energy emissions of radionuclide
– Easily collimated and shielded (lower dose to personnel)
– easily detected using NaI crystals (e.g. Tc-99m decays by 140 keV photons which is ideal)
Definition of Radiopharmaceutical
• Radioactive compound used for diagnosis and/or therapy of diseases
• In nuclear medicine, ~95% of radiopharmaceuticals used for diagnosis, while the rest are used for therapy
• The crystals used in gamma cameras are typically 40-60 cm in diameter and 1 cm thick
Collimator
• The purpose of the collimator is to define a field of view
• Mechanisms of interaction are:
– Photoelectric effect – Compton scatter – Pair production (not relevant to NM)
Sodium Iodide Detector, cont’d...
全新版大学英语综合教程2(第二版)UNIT3课后语句翻译
Text AProfessor Hawking thinks it important to keep everybody in touch withwhat science is about. In this article he explains why.霍金教授认为使每个人都了解科学是干什么的非常重要。
在这篇文章中,他对其中的缘由作了解释。
Public Attitudes Toward ScienceStephen Hawking1 Whether we like it or not, the world we live in has changed a greatdeal in the last hundred years, and it is likely to change even more inthe next hundred. Some people would like to stop these changes and go backto what they see as a purer and simpler age. But as history shows, thepast was not that wonderful. It was not so bad for a privileged minority,though even they had to do without modern medicine, and childbirth washighly risky for women. But for the vast majority of the population, lifewas nasty, brutish, and short.公众科学观斯蒂芬·霍金无论我们是否愿意,我们生活的世界在过去一百年间已经变化了许多,而且在未来的一百年里可能变化更多。
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NUCLEAR MEDICINE AND ITS RELEV ANCE TO THE SHROUD OF TURINAugust D. Accetta MD, Kenneth Lyons MD, John Jackson PhD.Hypothesis: If indeed a corpse created the image we see on the Shroud, then the source for the energy received by the cloth may be from the molecular bond energy and/or nuclear forces within the body in some way interacting with the cloth. The closest practical tool we have to study this today is nuclear medicine.Keywords: STURP: Shroud of Turin Research Project, Tc-99m MDP: Technesium-99 metastable methylene diphosphate, V-P-8: V ertical projection photodensitometer.Introduction: The Turin Shroud bears an image of an apparent crucified man, chemically the result of some dehydrative, oxidative, and subsequent carbonyl conjugative process of cellulose, the origin of which is heretofore enigmatic.1 Many properties of the Shroud are however under-stood quite well. For example, it is clearly understood through the work of STURP and others that the Shroud did in fact wrap someone at some point in time and that it is not the product of some medieval artist.2The Shroud image suggests quite strongly the presence of many skeletal details e.g. carpal and metacarpal bones, some 22 teeth, eye sockets, left femur, left and possibly right thumbs flexed under the palms of the hands, as well as soft tissue and soft tissue injuries; all presumably originat-ing from some form of radiation emitted from the body enshrouded.3No scientific human model has been satisfactorily utilized to offer elucidation of the origin of this quality an image. Many have postulated image formation theories e.g. Pellicori-Germans “latent image” and Jackson et al direct contact experiments which he concluded had quite negative results and have effectively been ruled out.4 Others have suggested diffusion.5 Schwalbe and Rojers however, failed in the properties not limited to sharpness and clarity of the image.6 Later researchers such as Giles Carter and Thaddeus Trenn have studied radiation biology in a theoreti-cal framework and have achieved promising results in terms of image superficiality and clarity.7The human radiation model seems to offer the greatest application to the Shroud image thus far.MATERIALS AND METHODSTc-99m is a metastable (i.e. 99 “m”) isotope that decays with a six (6) hour half life yielding a single gamma ray at 140 kev, (There are low energy characteristic x-rays 20 kev and below which are not detectable by our cameras).We used a gamma camera with a 3/8” thick, wide field, sodium iodine crystal which is ideally suited to the 140 kev energy of Tc-99m MDP. The energy resolution is 9.8% and sensitivity is 135cpm/microcurie. The collimator used was a long bore ultra high resolution, yielding a system resolution of 7.5 mm @ 10cm and 11mm @ 15cm. The long septal length preserves resolution at depth with 11mm @ 15cm.The Tc-99m or MDP Binds to bone by chemisorption. Approximately 50 % of the injected Tc-99m MDP or HMDP is taken up in the bones.High quality images depend upon an optimum target to background ratio. Thus the percentage of Tc-99m MDP compound that binds to protein and red blood cells greatly affects the quality of the bone scan. Tc-99m MDP is more satisfactory for bone than other compounds due to low protein binding and rapid clearance from soft tissue and blood by renal excretion. At 2 hours post injec-tion about 10% of administered Tc-99m MDP is protein bound. At 4 hours post injection, 3% of the injected per liter dose of Tc-99m polyphosphate is bound to RBC’s and 0% of Tc-99m MDP or HMDP is bound.We did timed sequence scanning in order to manipulate this predictable bioavailability to optimize our soft tissue to bone ratio (background to target). The early images during the first 15 minutes had a high soft tissue and blood component. Later as the blood level and soft tissue concentration diminished, most of the photons came from bone. The last images were showing primary bone photons with most of the soft tissue contribution attributed to low angle scattered photons.CONCLUSIONSThe human radiation model we used generated a number of characteristics which parallel the image on the Turin Shroud. It must be noted that these researchers in no way are claiming that they reproduced any of the exact characteristics of the Shroud image. Rather, those characteris-tics which are similar can potentially help to explain better those seen on the Shroud as well as point to the probable general origin of its image.First we demonstrated that a human model can be used to generate images resulting from emitted radiation, that resemble the image on the Shroud. (see fig. 1)Shroud ImageNuclear Imagefig1.Second we demonstrated that this radiation when captured by a vertical collimator can yield the verticality parallel seen on the Turin image.Third we demonstrated that the nature of the emitted radiation is such that it produces an image void of a sharp outline such as that on the Turin Shroud. (see fig. 2)Fourth we demonstrated that the resulting radiation image is void of any light focus such as theShroud. (see fig. 3)fig. 2fig. 3Nuclear ImageShroud ImageNuclear Image Shroud ImageFifth, due to the nature of the collimator, no side images are observed though the radiation is being emitted circumferentially. (see fig. 3)Sixth, the fact that soft tissues, skeletal information, as well as pathology in these tissues, can all be imaged concomitantly using the nuclear medicine model, demonstrates the parallel to the Shroud where the same is observed. (see fig. 4)Seventh we demonstrated that the thumb flexed under the palms of the left and right hands can be imaged, (precluding the need of any so called contact method), which parallels the Shroud. In addition, the V-P-8 image of the hands demonstrate the underlying thumb similar to that of theShroud.(see fig. 5)(fig. 4 notice metacarpal bones andphalanges noted in both images.)(fig. 5)Nuclear ImageShroud ImageNuclear ImageShroud ImageEighth we demonstrated that the nature of the emitted radiation was volumetric in that the image generated had higher density shading (higher number of pixels) towards the center or midline of extremities, digits, and torso, then fell off in intensity laterally. This differential dosimetry should and in fact does yield a Z-axis relief (or isometric projection) when scanned by V-P-8photodensitometer. (see fig. 6)(fig. 5 cont.)(fig. 6)Nuclear ImageShroud ImageNuclear ImageNinth, isometric projection (V-P-8) of our generated images, yielded a striking similarity to the V-P-8 image of the Shroud at the fall off of the left fingers. Knowing this is due to a 75-80% drop in signal intensity on our image, its relevance to the same phenomenon on the Shroud should not be overlooked and seriously considered to be a function of a similar effect i.e. a dosimetric sudden fall off of signal or radiation. (see fig. 7)SUMMARY The radiation model described in this study characterized much of what we see in the Shroud image in terms of the behavior of radiation being emitted from a human source. We believe the nuclear medicine model is the best currently available to aid in our understanding of the Shroud image. We feel our results effectively demonstrated plausibly that the Shroud image resulted from an organized emission and/or organized collection of radiation from the body and/or cloth respec-tively.(fig. 7 Note the dramaticfalloff of the proximalphalanges.)Nuclear ImageShroud ImageNOTE FOR FUTURE STUDIESThough we obtained quite analogous results with respect to arm, hand, and leg images, the head image was highly distorted on V-P-8 (i.e. not yielding a conforming relief of a natural face). The author believes this distortion arose from the volume of radiation emitted from the distal two-thirds of the head. This can be studied in a future experiment by subtracting out this radiation, which we plan to do in the near future.REFERENCES:1. Heller and Adler, 1981. A Chemical Investigation of the Shroud of Turin. Journal of the Canadian Society of Forensic Sciences 4 (3): 81-103.2. Heller, J.H. and A.D. Adler, 1980. Blood on the Shroud of Turin, Jackson, John P., 1989 Shroud Spectrum International.3. Whanger A. and M. Whanger 1985. Polarized Image Overlay. Applied Optics 24 (6):766-772.4. Jumper et al. Archaeological Chemistry III, pp 447-476.5. Schwalbe and Rogers, 1982: 35; Jackson, Jumper and Ercoline, 1984: 2264.6. Schwalbe and Rogers, 1982: 32-33. Physics and Chemistry of the Shroud of Turin, Analytica Chimica Acta, 135: 3-49.7. Carter, Giles F. 1984. Formation of Images on the Shroud by X-rays: A New Hypothesis. ACS Advances in Chemistry No. 205: Archaeological Chemistry, pp 425-446.。