胱抑素C及同型半胱氨酸的血清含量与糖尿病肾病患者肾小球滤过率的相关性研究

胱抑素C及同型半胱氨酸的血清含量与糖尿病肾病患者肾小
球滤过率的相关性研究
丁波;张倩;吴锦丹;朱余兵;马建华
【期刊名称】《实用医学杂志》
【年(卷),期】2012(028)008
【摘要】目的:通过检测血胱抑素C(Cystatin C,CysC)、同型半胱氨(Homocysteine,Hcy)浓度及尿白蛋白清除率(urine albumin excretion
rate,UAER)在糖尿病肾病(diabetic nephropathy,DN)进程中的变化以及与肾小球滤过率(glomerular filtration rate,GFR)的相关性,探讨其在DN诊断中的价值.方法:共47例患者,根据肾小球滤过率将其分为早期糖尿病肾病组(early-DN
组,GFR≥60 mL/min)及晚期糖尿病肾病组(end-DN组,GFR<60 mL/min),比较两组间CysC、Hcy的变化以及与肾小球滤过率的相关性.结果:end-DN组CysC、UAER均高于early-DN组(P<0.01).相关分析显示肾小球滤过率与CysC、Hcy、UAER负相关(r=-0.584,P=0.000;r=-0.547,P=0.000;r=-0.507,P=0.000),在慢性肾脏病(chronic kidney disease,CKD)Ⅱ、Ⅲ期,肾小球滤过率与CysC、Hcy负相关(r=-0.617,P=0.000;r=-0.431,P=0.018).结论:糖尿病患者中,伴随慢性肾脏病进程,CysC、Hcy、UAER逐渐升高,尤其在CKD Ⅱ、Ⅲ期,CysC、Hcy联合检测与UAER比较,能更好的反应糖尿病肾病肾小球滤过功能异常.%Objective To demonstrate the diagnostic value of serum cystatin C and homocysteine in diabetic nephropathy patients, and the relationship between the serum cystatin C and homocysteine level and glomerular filtration rate. Methods A total of 47 diabetic patients were divided into two groups based on GFR
detection by using isotope 99mTc-DTPA renal dynamic imaging:early stage diabetic nephropathy group (n = 27, GFR ^ 60 mL/min) and end stage diabetic nephropathy group (n = 20, GFR < 60 mL/min). Serum cystatin C , homocysteine and urine albumin excretion rate were detected in all patients. Results The CysC and UAER in the end-DN group were higher than those in the early-DM group. The correlation analysis showed that GFR was negatively correlated with CysC, Hey and UAER (r= -0.584, P= 0.000; r = -0.547, P= 0.000; r = -0.507, P= 0.000), The correlation analysis were also performed in chronic kidney disease at stage II and IH , and GFR was also negatively correlated with Cys C and Hey (r = -0.617, P=0.000; r =-0.431, P = 0.018). Conclusion The levels of serum cystatin C, homocysteine and urine albumin excretion were significant increased in the patients of end diabetic nephropathy, especially in the patients of chronic kidney disease at stages II and IH. CysC and Hey can be used as new good makers for early diabetic nephropathy diagnosis.
【总页数】3页(P1268-1270)
【作者】丁波;张倩;吴锦丹;朱余兵;马建华
【作者单位】210012,南京医科大学附属南京第一医院内分泌科;210012,南京医科大学附属南京第一医院药学部;210012,南京医科大学附属南京第一医院内分泌科;210012,南京医科大学附属南京第一医院药学部;210012,南京医科大学附属南京第一医院内分泌科
【正文语种】中文
【相关文献】
1.糖尿病肾病血清胱抑素C的变化及与肾小球滤过率的相关性研究 [J], 丁波;吴锦丹;罗勇;胡蕴;张文礼;马建华
2.高同型半胱氨酸与糖尿病肾病患者血胱抑素C相关性研究 [J], 刘艳;柳洁
3.糖尿病肾病血清超敏C反应蛋白、同型半胱氨酸与胱抑素C的相关性研究 [J], 李秀
4.糖尿病肾病患者血清胱抑素C及同型半胱氨酸的变化及相关性研究 [J], 涂良水;詹爱霞
5.老年2型糖尿病肾病患者尿液足细胞血清胱抑素C血清同型半胱氨酸水平与肾功能的相关性 [J], 马建和;孙继云
因版权原因，仅展示原文概要，查看原文内容请购买。