七氟烷后处理对大鼠在体心肌抗氧化的影响

七氟烷后处理对大鼠在体心肌抗氧化的影响
李婧;韩冲芳;李晓欣;杜艺;杨文曲
【期刊名称】《中国医药导报》
【年(卷),期】2011(8)20
【摘要】目的:探讨七氟烷后处理对大鼠在体心肌抗氧化的作用及最佳浓度.方法:
将40只健康雄性SD大鼠分为5组,即假手术组(C组)、缺血再灌注组(IP组)、1%、2%、3%七氟烷后处理组(S1、S2、S3组),每组各8只,建立大鼠在体心肌缺血再灌注模型.测定再灌注3 h后血浆MDA、SOD和CK-MB含量和心肌梗死面积.结果:与IP组相比,各S组心肌梗死面积、MDA、CK-MB均显著降低(P<0.05),SOD含
量均显著升高(P<0.05).S1组与S3组各指标间比较,差异无统计学意义(P>0.05).与S1、S3组相比,S2组心肌梗死面积(28.5±1.35)%、MDA(8.205±2.874) nmol/ml、CK-MB(22.935±2.064) U/L均显著降低(P<0.05),SOD含量显著升高(P<0.05).结论:七氟烷后处理可通过调节MDA与SOD的表达,发挥心肌保护作用,且中剂量组(2%七氟烷)效果更明显.%Objective: To investigate the antioxidation of sevoflurane postconditioning in rat hearts in vivo and the best concentration. Methods: A total of 40 SD rats were randomly divided into 5 groups, sham operation group (group C), ischemia and reperfusion group (group IP), 1％, 2％, 3％ sevoflurane posteonditioning group (group S1, group S2, group S3), 8 in every group, the model of rats＇ myocardial ischemia reperfusion was established. After being reperfused for 3 h, the blood SOD, MDA, CK-MB and myocardial infarct size were measured. Results: Compared with group IP, expression of myocardial infarct size,
MIA, CK-MB in S groups were significantly lower (P＜0.05), while the level of SOD was significantly higher (P＜0.05). There was no significant differenee between group S1 and group S3 (P＞0.05). Compared with group S1 and group S3, expression of myocardial infarct size (28.5±1.35)％, MDA (8.205±2.874) nmol/ml, CK-MB (22.935±2.064) U/L in group S2 were significantly lower (P＜0.05), while the level of SOD was significantly higher (P＜0.05). Conclusion: Postconditioning with sevoflurane protects the heart of the rat against ischemia reperfusion injury, and 2％ sevoflurane has a better protective effect.
【总页数】2页(P15-16)
【作者】李婧;韩冲芳;李晓欣;杜艺;杨文曲
【作者单位】山西医科大学第一医院麻醉科,山西太原,030001;山西医科大学第一医院麻醉科,山西太原,030001;山西医科大学第一医院麻醉科,山西太原,030001;山西医科大学第一医院麻醉科,山西太原,030001;山西医科大学第一医院麻醉科,山西太原,030001
【正文语种】中文
【中图分类】R965
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