外周血白细胞热休克蛋白70mRNA在太极拳运动后的表达

外周血白细胞热休克蛋白70mRNA在太极拳运动后的表达杨德洪;魏勇
【期刊名称】《中国组织工程研究》
【年(卷),期】2011(015)041
【摘要】背景:大部分研究显示,太极拳运动有望通过改善机体免疫功能而延缓衰老,但其机制不明.目的:观察太极拳运动后外周血白细胞热休克蛋白70 mRNA 的表达情况.方法:在健康中老年女性学练太极拳前、练习3 个月和6 个月时对其外周血白细胞热休克蛋白70 mRNA 表达进行实时定量PCR 检测.结果与结论:经过3 个月的太极拳运动干预,中老年妇女外周血白细胞热休克蛋白70 mRNA 的表达量与干预前比略增加,但没有明显差异,但干预6 个月后表达量下降明显,与干预前和干预3 个月的表达量相比差异均有显著性意义.结果初步表明热休克蛋白mRNA 表达的改变反映了太极拳健身的效果,而热休克蛋白的分子伴侣作用是太极拳健身效果的可能机制.%BACKGROUND: Several studies have demonstrated that Taiji-quan exercise is promosing to improve organism's immune function and then postpone aging, but the underlying mechanisms remain poorly understood. OBJECTIVE: To investigate the heat shock protein 70 (HSP70) expression in peripheral white blood cells after Taiji-quan exercise. METHODS: The HSP70 mRNA expression was detected by real-time quantitative PCR in peripheral white blood cells of healthy middle-aged and elderly women before, 3 and 6 months after Taiji-Quan exercise. RESULTS AND CONCLUSION: After 3 months of intensive Taiji-Quan exercise, HSP70 mRNA expression was slightly, but not significantly,
increased, compared with before Taiji-Quan exercise. After 6 months of Taiji-Quan exercise, HSP70 mRNA expression was significantly decreased, compared with before exercise and after 3 months of Taiji-Quan exercise. These results suggest that HSP70 mRNA expression can reflect the health benefits of 48-style Taiji-Quan exercise in middle-aged and elderly women and HSP 70 may be the potentioal molecular biological mechanism.
【总页数】4页(P7787-7790)
【作者】杨德洪;魏勇
【作者单位】上海应用技术学院体育教育部,上海市,201418;上海体育学院运动科学学院,上海市,200438
【正文语种】中文
【中图分类】R318
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