EPIDERMAL DIFFERENTIATION MICRORNA SIGNATURE AND U
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专利名称：EPIDERMAL DIFFERENTIATION MICRORNA SIGNATURE AND USES THEREOF
发明人：MARIONNET, CLAIRE,BERNERD, FRANCOISE 申请号：EP10760274.0
申请日：20100902
公开号：EP2473627A1
公开日：
20120711
专利内容由知识产权出版社提供
摘要：The present invention relates to a method for determining the state of epidermal differentiation of a human keratinocyte in a human epithelium sample, said method including determining the level of expression of at least one microRNA selected from among hsa-miR-455-3p, hsa-miR-141, hsa-miR-148a, hsa-miR-182, hsa-miR-224, hsa-miR-26a, hsa-miR-26b, hsa-miR-361-5p, hsa-miR-425, hsa-miR-92b, hsa-let-7i, hsa-miR-22, hsa-miR-221, hsa-miR-222, hsa-miR-29a, hsa-miR-29b, hsa-miR-663, hsa-miR-30a, and hsa-miR-30c within said keratinocyte, and comparing the level of expression of the microRNA(s) selected at the mean level of expression of the microRNA(s) selected in the undifferentiated keratinocytes or in differentiated epidermal keratinocytes, preferably from the same strain or the same population. The present invention also relates to various uses of the method for determining the state of epidermal differentiation, as well as to pharmaceutical or cosmetic compositions.
申请人：L'OREAL
地址：14, rue Royale 75008 Paris FR
国籍：FR
代理机构：Almond-Martin, Carol 更多信息请下载全文后查看。