紫杉醇腹腔灌注化疗治疗胃癌恶性腹腔积液的临床研究

紫杉醇腹腔灌注化疗治疗胃癌恶性腹腔积液的临床研究
李翔
【期刊名称】《江西医药》
【年(卷),期】2015(50)5
【摘要】目的：观察紫杉醇（PTX）腹腔灌注化疗联合亚叶酸钙（LV）/5-氟尿嘧啶（5-Fu）/奥沙利铂（OXA）治疗胃癌恶性腹腔积液的疗效及安全性。

方法23
例晚期胃癌合并癌性腹水患者接受PTX 60mg/m2腹腔灌注，第1，5，8d；LV 200mg/m2静脉滴注2h，第1-4d；5-Fu 750mg/m2持续静滴24h，每天1次，第1-4d；OXA 130mg/m2静滴2h，第1d。

每21d为1个周期，每2个周期评价疗效。

结果所有患者均可评价；有效率（RR）为69.6%，疾病控制率（DCR）
为86.9%，中位肿瘤进展时间（TTP）为6.6个月，1年生存率为71%。

主要不良反应有骨髓抑制、恶心呕吐、腹痛、腹泻、肌肉关节痛、口腔黏膜炎等，未见过敏反应及明显的肝肾功能损害，无治疗相关性死亡。

结论紫杉醇腹腔灌注化疗治疗胃癌恶性腹腔积液疗效较好，且不良反应较轻，可以耐受，值得临床进一步推广应用。

%Objective To observe the efficacy and safety of Paclitaxel (PTX) peritoneal perfusion chemotherapy combined with leucovorin(LV)/5-fluorouracil(5-Fu)/Oxaliplatin (OXA) in treating malignant ascites of gastric cancer. Methods Twenty-three cas-es of advanced gastric cancer with malignant ascites were treated with PTX 60mg/m2 via intraperitoneal on day 1,5,8;LV 200mg/m2 intravenous infusion for 2 hours on day 1 to 4;5-Fu 750mg/m2 intravenous infusion for 24 hours everyday on day 1 to 4;OXA 130mg/m2 intravenous infusion for 2 hours on day 1. The treatments were
repeated every three weeks,the therapeutic effects were evaluated once every two weeks. Results All patients could be evaluated;The response rate (RR) was 69.6%,the disease control rate (DCR) was 86.9%,the median time to progression (TTP) was 6.6 months,one year survival rate was 71%. Major adverse reac-tions included bone marrow restraint,nausea and vomiting,abdominal pain,diarrhea,joint and muscle pain,oral inflammation;no allergic reaction and the obvious function of liver and kidney damage,there was no therapy-related death in all patients. Conclu-sion Intraabdominal infusion of Paclitaxel was effective in treating malignant ascites of gastric cancer,and the toxicity was rela-tively mild and tolerable;These results indicate that further clinical study is worthy.
【总页数】4页(P390-393)
【作者】李翔
【作者单位】江西省肿瘤医院内三科，南昌 330029
【正文语种】中文
【中图分类】R735.2
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