GAMMA-BUTYROLACTOL ETHER DERIVATIVES

专利名称：GAMMA-BUTYROLACTOL ETHER
DERIVATIVES
发明人：WHITTAKER, Mark,DAVIDSON, Alan,
Hornsby,SPAVOLD, Zoe, Marie 27 Common
Road North Leigh,BOWLES, Stephen, Arthur 申请号：EP91908494.0
申请日：19910416
公开号：EP0527817A1
公开日：
19930224
专利内容由知识产权出版社提供
摘要： Compounds of general formula (I) wherein W represents an aromatic heterocyclic ring of 5 or 6 members containing in its ring one or Lots atoms non-quaternised sp2 nitrogen, said heterocyclic ring may optionally be united with a benzene ring or another aromatic heterocyclic ring of 5 or 6 members containing one or more nitrogen atoms, at least one of said heterocyclic rings may also contain an oxygen or sulfur atom, and wherein any of the rings may optionally be substituted by one or more substituents selected from C1-C6 alkoxy C1-C6 alkyl, halo, CF3 and CN; Z represents: a) alkanediyl, alkènediyle or C2-8 divalent alkynediyle may be a straight or branched chain having at least 3 carbon atoms in the chain linking W and the oxygen atom. Said group being unsubstituted or substituted by one or more substituents selected from hydroxy, C1-C6 alkylthio C1-C6 alkyl and halo; or b) a group alpha, wherein n is an integer from 0 to 3, X is O, S or CH2 and R7 and R8 are independently of each other hydrogen or C1-C6; or c) a group - (CH2) qU (CH2) r- wherein q is an integer between 0 and 2, r is an integer between 1 and 3, and U is a phenylene, furandiyle, tétrahydrofurandiyle, thiophenediyl,
tétrahydrothiophénediyle, thiazolediyl or tétrahydrothiazolediyle; R1 represents a group V wherein V is a beta group, wherein t is an integer between 0 and 3, and R9, R10 and R11 are independently of each other hydrogen, C1-C6 alkoxy C1-C6 thioalkyl, C1-C6 alkyl, halo, CN, NO2, SOC1-C6 alkyl, SO2C1-C6 alkyl, SO2 (CH2) 1-4CH2OH, SO2NH2, CO2H,
CO2C1-C6 alkyl, CHO, COC1-C6 alkyl , CH2OH, OH, benzyl, benzoyl, CF3, CONH2, NHCOC1-C6 alkyl or a group NR15R16 wherein R15 and R16 are independently of each other hydrogen or C1-C6; and R2, R3, R4,
申请人：BRITISH BIO-TECHNOLOGY LIMITED
地址：Watlington Road Cowley Oxford OX4 5LY GB
国籍：GB
代理机构：Roberts, Alison Christine (GB)
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