二甲双胍联合利拉鲁肽对糖尿病患者糖脂代谢、胰岛素抵抗及血清炎
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ZHAI Xiaoqu LI Qiliang Department of Endocrinology, Panyu District Hexian Memorial Hospital, Guangzhou 511400, China [Abstract] Objective To investigate the effects of metformin combined with liraglutide on glucose and lipid metabolism, insulin resistance and serum inflammatory factors in patients with diabetes. Methods 100 patients who underwent diabetes treated in our hospital from January 2018 to December 2018 were selected and randomly divided into a study group and a control group. Patients in the control group were treated with metformin, while patients in the study group were treated with liraglutide combined with metformin. Related indexes of glucose and lipid metabolism, insulin resistance and serum inflammatory factor levels were compared between the two groups. Results The indexes of glucose and lipid metabolism in the study group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of fasting insulin (FIns) and homeostasis model assessment of insulin resistance (HOMA-IR) in the study group were significantly lower than those in the control group, and the homeostasis model assessment-β (HOMA-β) condition was significantly higher than that in the control group (P < 0.05); the serum levels of inflammatory factors in the study group were significantly lower than those in the control group after treatment (P < 0.05). Conclusion The combined treatment of metformin and liraglutide for diabetic patients can help reduce the related indexes of glucose and lipid metabolism of patients, significantly improve the patient's insulin resistance and reduce the level of inflammatory factors in patients, which is worthy of clinical promotion and application. [Key words] Metformin; Liraglutide; Glucose and lipid metabolism; Insulin resistance; Serum inflammatory factors
Effects of metformin combined with liraglutide on glucose and lipid metabolism, insulin resistance and serum inflammatory factors in patients with diabetes
2020年2月第10卷第3期
·临床药物应用·
பைடு நூலகம்
二甲双胍联合利拉鲁肽对糖尿病患者糖脂代谢、 胰岛素抵抗及血清炎症因子的影响
翟小趣 李启亮 广州市番禺区何贤纪念医院内分泌科,广东广州 511400
[ 摘要 ] 目的 探讨二甲双胍联合利拉鲁肽对糖尿病患者糖脂代谢、胰岛素抵抗及血清炎症因子的影响。 方法 选取 2018 年 1 ~ 12 月在我院接受糖尿病治疗的 100 例患者作为本研究对象,将其随机分为研究组与对照组。 对照组患者采用二甲双胍治疗,研究组患者在对照组的基础上联合采用利拉鲁肽治疗。比较两组患者的糖脂代 谢的相关指标,胰岛素抵抗情况以及血清的炎症因子水平。 结果 研究组患者糖脂代谢的各项指标与对照组比 较显著较低(P < 0.05);治疗后研究组患者的 FIns 水平以及 HOMA-IR 水平与对照组比较显著较低,HOMA-β 情况显著高于对照组(P < 0.05);治疗后研究组患者的血清的炎症因子水平与对照组比较明显较低(P < 0.05)。 结论 对糖尿病患者采用二甲双胍与利拉鲁肽联合治疗的方式,有助于患者糖脂代谢相关指标的降低,显著改善 患者胰岛素的抵抗情况,同时能够显著降低患者的炎症因子水平,利于在临床治疗中应用及推广。 [ 关键词 ] 二甲双胍;利拉鲁肽;糖脂代谢;胰岛素抵抗;血清炎症因子 [ 中图分类号 ] R587.1 [ 文献标识码 ] A [ 文章编号 ] 2095-0616(2020)03-77-04
Effects of metformin combined with liraglutide on glucose and lipid metabolism, insulin resistance and serum inflammatory factors in patients with diabetes
2020年2月第10卷第3期
·临床药物应用·
பைடு நூலகம்
二甲双胍联合利拉鲁肽对糖尿病患者糖脂代谢、 胰岛素抵抗及血清炎症因子的影响
翟小趣 李启亮 广州市番禺区何贤纪念医院内分泌科,广东广州 511400
[ 摘要 ] 目的 探讨二甲双胍联合利拉鲁肽对糖尿病患者糖脂代谢、胰岛素抵抗及血清炎症因子的影响。 方法 选取 2018 年 1 ~ 12 月在我院接受糖尿病治疗的 100 例患者作为本研究对象,将其随机分为研究组与对照组。 对照组患者采用二甲双胍治疗,研究组患者在对照组的基础上联合采用利拉鲁肽治疗。比较两组患者的糖脂代 谢的相关指标,胰岛素抵抗情况以及血清的炎症因子水平。 结果 研究组患者糖脂代谢的各项指标与对照组比 较显著较低(P < 0.05);治疗后研究组患者的 FIns 水平以及 HOMA-IR 水平与对照组比较显著较低,HOMA-β 情况显著高于对照组(P < 0.05);治疗后研究组患者的血清的炎症因子水平与对照组比较明显较低(P < 0.05)。 结论 对糖尿病患者采用二甲双胍与利拉鲁肽联合治疗的方式,有助于患者糖脂代谢相关指标的降低,显著改善 患者胰岛素的抵抗情况,同时能够显著降低患者的炎症因子水平,利于在临床治疗中应用及推广。 [ 关键词 ] 二甲双胍;利拉鲁肽;糖脂代谢;胰岛素抵抗;血清炎症因子 [ 中图分类号 ] R587.1 [ 文献标识码 ] A [ 文章编号 ] 2095-0616(2020)03-77-04