老年结肠癌病人循环与肿瘤组织中Galectin-3水平及临床意义

老年结肠癌病人循环与肿瘤组织中Galectin-3水平及临床意
义
任丽丽;耿建
【期刊名称】《实用老年医学》
【年(卷),期】2017(031)002
【摘要】Objective To evaluate the clinical relevance and prognostic effects of Galectin-3 in elderly patients with colorectal cancer. Methods Sixty-eight old patients with colorectal cancer who received surgical resection were enrolled in this study. The expression of Galectin-3 in tissue sections was evaluated using immunohistochemical staining. Serum level of Galectin-3 was measured using an enzyme-linked immunosorbent assay.
In addition, fifty healthy volunteers were chosen as controls. The relationship of Galectin-3 expression in tissue sections and serum level of Galectin-3 with clinicopathological factors and prognosis was analyzed. Results Serum level of Galectin-3 was higher in the patients with colorectal cancer compared to the control group ( P<0. 001) . Serum level of Galectin-3 was not significantly associated with tumor size, distant metastasis, TNM stage and prognosis in the patients with colorectal cancer. Patients with positive expression of Galectin-3 showed higher carcinoembryonic antigen level, tumor size, higher Dukes’ stage and TNM Stage, higher incidence of lymph node and distant metastasis than those with negative expression of Galectin-3 ( P< 0. 01, respectively) .
However, the survival period in patients with positive expression of Galectin-3 was&nbsp;significantly poorer than those with negative expression of Galectin-3(P<0. 01). Conclusions Serum level of Galectin-3 increases in the patients with colorectal cancer. Galectin-3 expression in tissue sections is an independent factor for the severity degree of the disease and prognosis of colorectal cancer.%目的：分析老年结肠癌病人循环和肿瘤组织中半乳糖凝集素-3（ Galectin-3）表达情况，以及与病人一般情况、肿瘤分期及预后的关系。

方法收集自1999年3月至2010年12月在我科住院明确诊断的老年结肠癌病人68例，另收集50例健康体检者为对照组，测定其循环中Galectin-3水平。

收集病人临床信息与实验室检查结果，采用双抗体夹心法测定循环Galectin-3水平，切除的肿瘤组织行抗Galectin-3免疫组化染色。

将循环Galec-tin-3水平和肿瘤组织Galectin-3表达情况与病人相关资料行相关分析。

结果68例老年结肠癌病人循环Ga-lectin-3水平显著高于对照组（ P＜0.001）；循环Galectin-3水平与肿瘤长径、肿瘤转移、TNM分期及预后无相关性（ P＞0.05）；肿瘤组织Galectin-3表达阳性病例与阴性病例在血清CEA水平、肿瘤长径、Duke 分期、TNM分期、淋巴结转移、远处转移、生存时间方面差异均有统计学意义（ P均＜0.01）。

结论老年结肠癌病人循环Galectin-3水平显著升高，肿瘤组织Galectin-3表达情况可预示病情和预后。

【总页数】4页(P153-156)
【作者】任丽丽;耿建
【作者单位】210002 江苏省南京市，南京大学医学院附属金陵医院肿瘤内
科;210002 江苏省南京市，南京大学医学院附属金陵医院肿瘤内科
【正文语种】中文
【中图分类】R735.35
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