磷酸西格列汀联合二甲双胍治疗初发2_型糖尿病的临床分析

DOI：10.16658/ki.1672-4062.2023.11.099

磷酸西格列汀联合二甲双胍治疗初发2型

糖尿病的临床分析

庄有霖1，卓龙2，邱小丹1

1.尤溪县中医医院药剂科，福建尤溪365100；

2.尤溪县中医医院内分泌科，福建尤溪365100

[摘要]目的研究磷酸西格列汀联合二甲双胍治疗初发2型糖尿病的临床效果。方法选取2019年6月—2021年6月尤溪县中医医院收治的81例初发2型糖尿病患者为研究对象，按照随机数表法分为对照组（40例，二甲双胍治疗）和观察组（41例，磷酸西格列汀+二甲双胍治疗），对比两组患者的临床治疗效果、体质量变化情况、血清生化指标、糖代谢指标、胰岛素指标、炎症反应指标、不良反应情况。结果观察组治疗总有效率高于对照组，差异有统计学意义（χ2=6.012，P<0.05）。观察组治疗后的体质指数低于对照组，差异有统计学意义（t=8.385，P<0.05）。治疗后，观察组同型半胱氨酸、脂蛋白a低于对照组，差异有统计学意义（t=6.894、17.185，P<0.05）。治疗后，观察组空腹血糖、餐后2 h血糖低于对照组，差异有统计学意义（t=10.834、8.053，

P<0.05）。治疗后，观察组空腹胰岛素高于对照组、胰岛素抵抗指数低于对照组，差异有统计学意义（t= 5.607、9.758，P<0.05）。治疗后，观察组超敏C反应蛋白低于对照组，差异有统计学意义（t=9.524，P<0.05）。观察组食欲下降、低血糖、头痛乏力不良反应总发生率与对照组比较，差异无统计学意义（χ2=0.104，P> 0.05）。结论磷酸西格列汀联合二甲双胍在初发2型糖尿病治疗中有效降低血糖水平，减少炎症发生，改善

患者胰岛素指标。

[关键词] 磷酸西格列汀；二甲双胍；初发2型糖尿病；不良反应

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2023）06（a）-0099-04

Clinical Analysis of Selegiline Phosphate Combined with Metformin in the Treatment of First-onset Type 2 Diabetes Mellitus

ZHUANG Youlin1, ZHUO Long2, QIU Xiaodan1

1.Department of Pharmacy, Youxi County Hospital of Traditional Chinese Medicine, Youxi, Fujian Province, 365100 China;

2.Department of Endocrinology, Youxi County Hospital of Traditional Chinese Medicine, Youxi, Fujian Prov‐ince, 365100 China

[Abstract] Objective To study the clinical effects of selegiline phosphate combined with metformin in the treatment of first-onset type 2 diabetes mellitus. Methods Eighty-one patients with first-onset type 2 diabetes mellitus from June 2019 to June 2021 admitted to Youxi County Hospital of Traditional Chinese Medicine were selected as research objects. According to the random number table method, they were divided into the control group (40 cases, treated with metformin) and the observation group (41 cases, treated with sitagliptin phosphate + metformin), and the clinical treatment effects, changes in body mass, serum biochemical indexes, glucose metabolism indexes, insulin indexes, in‐flammatory response indexes, and adverse reactions of the two groups of patients with first-onset type 2 diabetes melli‐tus were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (χ2=6.012, P<0.05). The body mass index after treatment in the observation group was lower than that in the control group, and the difference was statistically significant (t= 8.385, P<0.05). After treatment, homocysteine and lipoprotein were lower in the observation group than in the control group, and the difference was statistically significant (t=6.894, 17.185, P<0.05). After treatment, fasting blood glucose and 2 h postprandial blood glucose in the observation group were lower than those in the control group, and the differ‐ence was statistically significant (t=10.834, 8.053, P<0.05). After treatment, fasting insulin was higher and insulin re‐[作者简介]庄有霖（1979-），男，本科，主管药师，研究方向为临床药学。