第二章药效学PPT课件
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The effect that is nSoetctohnedaacrycorerdaction
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8
1. Acute toxicity
2. Chroanidc vtoexicristye: druSgidreeeaffcectiton
(carcinogenesis, Toxic effect
Ⅰtmeuratatcoggoeennneescsiseis),pt after effect
Allergic reaction
Chapter 2 Pharmacodynamics
Department of Pharmacology, Medical school of Nankai University
Jingling Zhang Tel: (office) E-mail:
Pharmacodynamics
教学目的 掌握药效学的基本概念和药 理作用的基本规律，为各论 药物的学习提供理论基础。
2
Pharmacodynamics
教学内容
药物的基本作用和效应；器官功能的升高或降 低，即兴奋和抑制。药物作用的选择性和可逆 性。 药物作用的临床效果，即治疗作用和不良反应。 药物作用原理；药物作用原理的多样性； 受体和配体的概念，受体在药物作用中的意义；
3
Pharmacodynamics
亲和力（pD2），内在活性（），受体激活至效 应器反应的中间过程；反馈的生理意义。
& side effect are tDhepinetnrdinesnicce 1. Physicparlodpeepretinedsenocfethe drug.
(withdrawal syndrome)
2. Psychic dependence
9
Dose-effect relationship
2. Margin of safety： ED95～TD5；
Structure-activity relationship
15
Targets for drug action
1. Receptors 2. Enzymes 3. Ion channels 4. Carrier molecules (transporters) 5. Gene
5
Pharmacodynamics
I. Drug action II. The therapeutic effect of drug and
adverse drug reaction (ADR) III. Dose-effect relationship IV. Structure-activity relationship V. Targets for drug action VI. Theory about interaction of drug and
1. Slope
which produce the same
2. Minimum effectivtheecroanpceeuntitcraetfifoenc，t.
threshold concentration
3. Maximum effect or Efficacy
4. Median effective dose, ED50 TD50 LD50
complementary the loss of nutrition & metabolism
1. Etiological treaotfmtheebnotdy 2. Symptomatic treatment 3. Supplementary therapy or
replacement therapy
18
Mechanism of drug action
Nonspecific mechanism of drug action
Specific Mechanisms of drug action
19
Interaction between drug and receptor
1. Concept of the receptor The term receptor is used in different ways. In pharmacology, it describes protein molecules whose function is to recognise and respond to endogenous chemical signals.
5. Potency
Baidu Nhomakorabea
the effect cannot
6. Effective dose；Toxiicncdroesaes；e wLeiththtahledose； Maximum dose addition of the drug.
13
14
Safety
1. Therapeutic index： TI=LD50/ED50；
1. Concept 2. Dose-effect curve 3. Type
① Graded response; ② Quantal response ( All-or-none
response ) 4. Significance
10
Special pointtashme：oenqgutivhaeledniftfedroesnet drugs
receptor
6
Drug action
excitation
1. Drug action
inhibition
2. Types of drug action
3. Selectivity of drug action
4. Pharmacological effect
7
The therapeutic effect of drug
激动药，部分激动药，对抗药的共性与个性，拮 抗参数pA2，
药物的构效关系。
药物作用的量效关系：质反应与量反应。量效关 系曲线，作用强度与最大效应，半数效应量， 阈剂量，治疗量，极量，中毒量及致死量。
4
Pharmacodynamics
Concept of pharmacodynamics It is the study of drug effects and their mechanisms of action.
Ⅱwwthihetthicyphtaphtieesiepnleuta.rpdTohtsoeetthhWIodeefiirodthahsrapduyrergnmaucuwtr&isacaesple,yrafefirenaeccaottcfiotinon
8
1. Acute toxicity
2. Chroanidc vtoexicristye: druSgidreeeaffcectiton
(carcinogenesis, Toxic effect
Ⅰtmeuratatcoggoeennneescsiseis),pt after effect
Allergic reaction
Chapter 2 Pharmacodynamics
Department of Pharmacology, Medical school of Nankai University
Jingling Zhang Tel: (office) E-mail:
Pharmacodynamics
教学目的 掌握药效学的基本概念和药 理作用的基本规律，为各论 药物的学习提供理论基础。
2
Pharmacodynamics
教学内容
药物的基本作用和效应；器官功能的升高或降 低，即兴奋和抑制。药物作用的选择性和可逆 性。 药物作用的临床效果，即治疗作用和不良反应。 药物作用原理；药物作用原理的多样性； 受体和配体的概念，受体在药物作用中的意义；
3
Pharmacodynamics
亲和力（pD2），内在活性（），受体激活至效 应器反应的中间过程；反馈的生理意义。
& side effect are tDhepinetnrdinesnicce 1. Physicparlodpeepretinedsenocfethe drug.
(withdrawal syndrome)
2. Psychic dependence
9
Dose-effect relationship
2. Margin of safety： ED95～TD5；
Structure-activity relationship
15
Targets for drug action
1. Receptors 2. Enzymes 3. Ion channels 4. Carrier molecules (transporters) 5. Gene
5
Pharmacodynamics
I. Drug action II. The therapeutic effect of drug and
adverse drug reaction (ADR) III. Dose-effect relationship IV. Structure-activity relationship V. Targets for drug action VI. Theory about interaction of drug and
1. Slope
which produce the same
2. Minimum effectivtheecroanpceeuntitcraetfifoenc，t.
threshold concentration
3. Maximum effect or Efficacy
4. Median effective dose, ED50 TD50 LD50
complementary the loss of nutrition & metabolism
1. Etiological treaotfmtheebnotdy 2. Symptomatic treatment 3. Supplementary therapy or
replacement therapy
18
Mechanism of drug action
Nonspecific mechanism of drug action
Specific Mechanisms of drug action
19
Interaction between drug and receptor
1. Concept of the receptor The term receptor is used in different ways. In pharmacology, it describes protein molecules whose function is to recognise and respond to endogenous chemical signals.
5. Potency
Baidu Nhomakorabea
the effect cannot
6. Effective dose；Toxiicncdroesaes；e wLeiththtahledose； Maximum dose addition of the drug.
13
14
Safety
1. Therapeutic index： TI=LD50/ED50；
1. Concept 2. Dose-effect curve 3. Type
① Graded response; ② Quantal response ( All-or-none
response ) 4. Significance
10
Special pointtashme：oenqgutivhaeledniftfedroesnet drugs
receptor
6
Drug action
excitation
1. Drug action
inhibition
2. Types of drug action
3. Selectivity of drug action
4. Pharmacological effect
7
The therapeutic effect of drug
激动药，部分激动药，对抗药的共性与个性，拮 抗参数pA2，
药物的构效关系。
药物作用的量效关系：质反应与量反应。量效关 系曲线，作用强度与最大效应，半数效应量， 阈剂量，治疗量，极量，中毒量及致死量。
4
Pharmacodynamics
Concept of pharmacodynamics It is the study of drug effects and their mechanisms of action.