血小板衍化生长因子在细胞增殖和组织修复中的作用及机制

中国组织工程研究与临床康复第15卷第2期2011–01–08出版

Journal of Clinical Rehabilitative Tissue Engineering Research January 8, 2011 Vol.15, No.2 ISSN 1673-8225 CN 21-1539/R CODEN: ZLKHAH

351

血小板衍化生长因子在细胞增殖和组织修复中的作用及机制*★

谢爱国1，梁红伟2，谭谦3

Role and mechanism of platelet-derived growth factor in cell proliferation and tissue repair Xie Ai-guo1, Liang Hong-wei2, Tan Qian3

Abstract

BACKGROUND: Cell proliferation and tissue repair is a complicated process, accompanied by participation of multiple growth

factors, and these factors from a system in which they play their roles not in an independent, but interacting and inter-restricting

manner.

OBJECTIVE: To summarize the role and mechanism of platelet-derived growth factor (PDGF) in cell proliferation and tissue

repair.

METHODS: PubMed, EMbase, Chinese Biomedical Literature Database, CNKI, CAJ were retrieved by computer with keywords of

“platelet-derived growth factor, cell proliferation, tissue repair”. The language was limited for English and Chinese.

RESULTS AND CONCLUSION: PDGF is one of the major mitogens and is responsible for proliferation and migration of various

cells. PDGF and its receptors located in multiple tissues and cells, which combined with receptors and play its role when the body

suffered certain stimulation. Thus, plenty of studies showed that the expression of PDGF gene was increased in the period of

surgery or damage repair. The biological characteristics of PDGF have been recognized primarily. The specific mechanism of

repair is not clarified and many problems need to be explored in further study.

Xie AG, Liang HW, Tan Q. Role and mechanism of platelet-derived growth factor in cell proliferation and tissue repair.Zhongguo

Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(2):351-355. [ ]

摘要

背景：细胞增殖和组织修复是一个复杂的过程，这期间有大量生长因子参与，并且这些因子在发挥本身功效时，同时还相互

影响和制约，从而更好地促进细胞增殖和组织修复。

目的：总结血小板衍化生长因子在细胞增殖和组织修复愈合过程中发挥的作用及其机制。

方法：检索PubMed数据库、EMbase数据库1960-01/2010-10期间相关文章，检索词为“platelet-derived growth factor，

cell proli ferati on，ti ssue repai r”。同时检索中国生物医学文献数据库、中文科技期刊全文数据库、中文学术期刊全文数据

库2000-01/2010-10期间相关文章，检索词为“血小板衍化生长因子”。

结果与结论：血小板衍化生长因子是一种重要的促细胞分裂剂，可刺激各种类型细胞的分裂增殖。血小板衍化生长因子及其

受体存在于机体的多种组织细胞，当机体受到一定的刺激时，血小板衍化生长因子与其受体结合，发挥作用，因此许多研究

发现，在外科手术后和损伤修复过程中常伴随有局部血小板衍化生长因子基因表达量的升高和受体的上调，被称为损伤修复

因子。但是它的具体作用机制尚不太明确，对细胞组织的增殖修复的认识还处于起始、发展阶段，还有许多的问题需要去探

索研究。

关键词：血小板衍化生长因子；细胞增殖；组织修复；综述

doi:10.3969/j.issn.1673-8225.2011.02.040

谢爱国，梁红伟，谭谦．血小板衍化生长因子在细胞增殖和组织修复中的作用及机制[J].中国组织工程研究与临床康复，2011，

15(2):351-355. [ ]

0 引言

血小板衍化生长因子(platelet-derived growth factor，PDGF)是1974年发现的一种刺激结缔组织常见的多肽类调节因子，最初从血小板分离，后又证实存在于成纤维细胞、星形角质细胞、角质化细胞、上皮细胞等多种细胞中，并可由许多细胞合成并释放[1]。近年来，随着分子生物学和细胞生物学的高速发展，对PDGF的研究逐步深入，其在细胞增殖和组织修复中发挥的重要作用也逐渐显示出来。本文就PDGF与细胞增殖和组织修复的研究近况进行综述。1 资料和方法

资料来源：由第一作者检索PubMed数据库

(1960-01/2010-10)、EMbase数据库(1960-01/

2010-10)、中国生物医学文献数据库(2000/

2010-10)、中文科技期刊全文数据库(2000-01/

2010-10)、中文学术期刊全文数据库(2000-01/

2010-10)。英文检索词为“p latelet- derived

growth factor， cell p roliferation，tissue repair”，

中文检索词为“血小板衍化生长因子”。检索文

献量总计98篇。

纳入标准：①文章所述内容需与PDGF在细

胞增殖，组织修复过程中发挥作用及其机制研究

1Department of

Burns and Plastic

Surgery, Second

Affiliated Hospital of

Nanjing Medical

University, Nanjing

210011, Jiangsu

Province, China;

2Department of

Plastic Surgery,

Zhengzhou People’s

Hospital, Zhengzhou

450003, Henan

Province, China;

3Department of

Plastic Surgery,

Drum Tower Hospital,

Medical College of

Nanjing University,

Nanjing 210008,

Jiangsu Province,

China

Xie Ai-guo★, Master,

Physician,

Department of Burns

and Plastic Surgery,

Second Affiliated

Hospital of Nanjing

Medical University,

Nanjing 210011,

Jiangsu Province,

China

dr.aigo@yahoo.

Supported by: the

Science

Development

Foundation of

Nanjing Medical

University, No.

09NJMUM 025*

Received: 2010-08-16

Accepted: 2010-10-23