壳聚糖磁性载药微球的研究及性能分析

本科学生毕业论文

壳聚糖磁性载药微球的研究

及性能分析

院系名称：材料与化学工程学院

专业班级：应用化学10-1班

学生姓名：唐宇佳

指导教师：王晓丹

职称：讲师

黑龙江工程学院

二○一四年六月

The Graduation Thesis for Bachelor's Degree Magnetic Chitosan Microspheres Research and Performance Analysis

Candidate:Tang Yujia

Specialty : Applied Chemistry

Class : 10-1

Supervisor:Lecture Wang Xiaodan

Heilongjiang Institute of Technology

2014-06·Harbin

摘要

近些年随着人们的生活水平及科技的提高，普通的药物已经不能满足人类的需求，因此在此基础上科学家们研究了新型的药物。壳聚糖(Chitosan)能使血液迅速地被凝固，我们通常用它来止血。由于它具有生物相容性所以还可以用它作为填埋伤口，其还能摧毁细菌、加快伤口的好转、吞噬分泌物、不受水的干扰等作用，磁流体是利用Fe3+和Fe2+以在碱性的条件下制取的。以壳聚糖、姜黄素、磁流体为原料采用复乳化交联法获得磁性载药壳聚糖微球。最后对磁性壳聚糖载药微球的磁性、形貌、药物缓释进行研究。

实验表明，最佳反应条件是壳聚糖醋酸溶液的浓度为 1.5%，适量的姜黄素和磁流体，乳化剂的量是壳聚糖醋酸溶液的20%，液体石蜡为200%，交联剂为50%,转速300r/min，反应温度在60℃时反应2h得粒径均匀的黄色的沉淀，即壳聚糖磁性载药微球，其外貌光滑，粒径在10~20μm之间，能在较长的时间里进行药物缓释，时间长达6小时以上。

关键词：壳聚糖；磁流体；姜黄素；载药微球；药物缓释

ABSTRACT

In recent years with the improvement of people's living standards and technology，common drugs have been unable to meet human needs，therefore，on this basis，scientists have studied the novel drug.Chitosan blood can be rapidly solidified，we usually use it to stop the bleeding. Because of its biocompatible so you can use it as a landfill wounds，It can also destroy bacteria and accelerate wound improved,swallowed secretions，interference and other effects from water，MHD is the use of Fe3+and Fe2+under alkaline conditions in preparation for.Chitosan,curcumin，magnetic fluid as raw materials using a complex emulsion cross linking method to obtain magnetic chitosan microspheres containing the drug，finally，the magnetic Chitosan microspheres magnetic morphology，drug delivery research.

Experiments show that The optimal reaction conditions for the concentration of chitosan was 1.5% acetic acid solution and the right amount of curcumin and magnetic fluids，the amount of emulsifier is 20% of chitosan acetic acid solution,liquid paraffin was 200%，crosslinking agent is 50%，the speed of 300 r/min，the reaction temperature of the reaction have a uniform particle size of the yellow precipitate 2h at 60℃，the chitosan magnetic carrier drug microsphere is.Its appearance is smooth，particle size between 10~20μm，the drug release can be a long time，he time up to more than six hours.

Key words: Chitosan; magnetic fluid; curcumin; microspheres; drug deliver

目录

摘要 .............................................................................................................................. I Abstract....................................................................................................................... II 第1章绪论.. (1)

1.1本课题的选题背景 (1)

1.2研究目的及意义 (1)

1.3国内外研究现状 (2)

1.3.1国外研究现状 (2)

1.3.2国内研究现状 (3)

1.4壳聚糖载药微球微球的简介 (4)

1.4.1载药微球 (4)

1.4.2壳聚糖简介 (5)

1.4.3壳聚糖应用 (5)

1.5主要研究内容 (7)

第2章壳聚糖空白微球的制备 (8)

2.1实验药品与仪器 (8)

2.1.1实验药品 (8)

2.1.2实验仪器 (8)

2.2空白微球 (8)

2.2.1壳聚糖空白微球的制备 (8)

2.3试验方法 (10)

2.3.1实验内容 (10)

2.3.2样品的表征 (10)

2.4结果与讨论 (11)

2.4.1反应温度对产物性能的影响 (11)

2.4.2对产物性能的影响 (11)

2.4.3联时间的影响 (11)

2.5本章小结 (12)

第3章壳聚糖磁性载药微球的制备 (13)