中国医科大学病理学英文课件9教案资料
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2020/5/14
Tumor (neoplasm):
under the stimulation of tumorgenic agents a single cell of local tissue loss the controlling to its growth at the gene level excessive proliferation to form
2020/n5/14eoplasm
Distinguish between neoplastic and non-neoplastic hyperplasia
Neoplastic
Monoclonality Abnormal morphology
and function Abnormal differentiation
But many problems still need to be solved!
2020/5/14
Section 1. Definition and morphology
Two question:
• What is tumor?
Definition
• What are tumors look like? Morphology
differentiation Persistent, autonomous Harmful
2020/5/14
Non-neoplastic
Polyclonality Normal morphology
and function Matured
Limited Beneficial
※Morphology and structure
2020/5/14
※Definition
• Neoplasia literally means the process of “new growth” and a new growth is called a neoplasm.
• tumor was originally applied to the swelling caused by inflammation.
2020/5/14
检查结果
1.左股骨下端X线正位像： 左股骨下端占位病变， 骨皮质破坏,骨膜反应。
2.胸部X线正侧位像： 未见明显异常
2020/5/14
临床诊断：恶性骨肿瘤？ 活检病理诊断：骨肉瘤
2020/5/14
思考题
1.什么是肿瘤？具有哪些特性？ 2.肿瘤有哪些种类、各自特点？ 3.肿瘤生物学行为如何？对机体有何影响
➢Macropathology: The gross appearance of tumors is
varied, reflecting the nature of the tumor to some rapid progress has been made in understanding the molecular basis and biological behavior of cancer and cancer therapy. Many cancers can be cure or arrested. For example: breast cancer, cervical cancer
Chapter 5. Neoplasia
2020/5/14
Xu HT
病例
ＸＸＸ，女，21岁 主诉：近半年左下肢膝关节附近疼痛，活动后
加重，一个月前发现左股骨下端局部隆 起，逐渐长大，疼痛难忍，来诊。 查体：左股骨下端局部肿物，压痛（＋） 处置：1. 左股骨下端X线正侧位像
2. 胸部X线正侧位像 3. 左股骨下端肿物穿刺活检
？ 4.肿瘤的结局如何？ 5.肿瘤是如何发生发展的？如何防治？
2020/5/14
Chapter 5. Neoplasia
Tumors is common diseases. Bad news: Malignant tumor (cancer) is the
second leading cause of death in some countries. (The first leading cause is cardiovascular diseases.) According to American Cancer Society estimates, in 2003, about 23% of all deaths in the United States (1500 cancer deaths per day).
• A more scientific difinition: “Neoplasia is genetic disease, in which the growth of tumors is loss of responsiveness to normal growth control, and shows an excessive hyperplasia with abnormal differentiation.”
• Oncology is the study of tumors or neoplasms.
• Cancer is the common term for all malignant tumors.
2020/5/14
Neoplasia
• In 1953, The eminent British oncologist Willis had given neoplasia a famous definition: “A neoplasm is an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the same excessive manner after cessation of the stimuli which evoked the change.”
Tumor (neoplasm):
under the stimulation of tumorgenic agents a single cell of local tissue loss the controlling to its growth at the gene level excessive proliferation to form
2020/n5/14eoplasm
Distinguish between neoplastic and non-neoplastic hyperplasia
Neoplastic
Monoclonality Abnormal morphology
and function Abnormal differentiation
But many problems still need to be solved!
2020/5/14
Section 1. Definition and morphology
Two question:
• What is tumor?
Definition
• What are tumors look like? Morphology
differentiation Persistent, autonomous Harmful
2020/5/14
Non-neoplastic
Polyclonality Normal morphology
and function Matured
Limited Beneficial
※Morphology and structure
2020/5/14
※Definition
• Neoplasia literally means the process of “new growth” and a new growth is called a neoplasm.
• tumor was originally applied to the swelling caused by inflammation.
2020/5/14
检查结果
1.左股骨下端X线正位像： 左股骨下端占位病变， 骨皮质破坏,骨膜反应。
2.胸部X线正侧位像： 未见明显异常
2020/5/14
临床诊断：恶性骨肿瘤？ 活检病理诊断：骨肉瘤
2020/5/14
思考题
1.什么是肿瘤？具有哪些特性？ 2.肿瘤有哪些种类、各自特点？ 3.肿瘤生物学行为如何？对机体有何影响
➢Macropathology: The gross appearance of tumors is
varied, reflecting the nature of the tumor to some rapid progress has been made in understanding the molecular basis and biological behavior of cancer and cancer therapy. Many cancers can be cure or arrested. For example: breast cancer, cervical cancer
Chapter 5. Neoplasia
2020/5/14
Xu HT
病例
ＸＸＸ，女，21岁 主诉：近半年左下肢膝关节附近疼痛，活动后
加重，一个月前发现左股骨下端局部隆 起，逐渐长大，疼痛难忍，来诊。 查体：左股骨下端局部肿物，压痛（＋） 处置：1. 左股骨下端X线正侧位像
2. 胸部X线正侧位像 3. 左股骨下端肿物穿刺活检
？ 4.肿瘤的结局如何？ 5.肿瘤是如何发生发展的？如何防治？
2020/5/14
Chapter 5. Neoplasia
Tumors is common diseases. Bad news: Malignant tumor (cancer) is the
second leading cause of death in some countries. (The first leading cause is cardiovascular diseases.) According to American Cancer Society estimates, in 2003, about 23% of all deaths in the United States (1500 cancer deaths per day).
• A more scientific difinition: “Neoplasia is genetic disease, in which the growth of tumors is loss of responsiveness to normal growth control, and shows an excessive hyperplasia with abnormal differentiation.”
• Oncology is the study of tumors or neoplasms.
• Cancer is the common term for all malignant tumors.
2020/5/14
Neoplasia
• In 1953, The eminent British oncologist Willis had given neoplasia a famous definition: “A neoplasm is an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the same excessive manner after cessation of the stimuli which evoked the change.”