幽门螺杆菌抗体胃泌素17胃蛋白酶原等联合检测

检查无胃疾病或仅有浅表性胃炎的对照组 100 例遥 采用放免技术测定体检人群血清中幽门螺杆菌抗体尧胃泌素 17尧胃蛋白酶原
玉尧域及其比值袁同时行胃镜检查袁胃镜下活检的病例均以病理诊断为准袁对血清学尧胃镜以及病理结果进行统计学分析遥 结果
胃癌前病变及胃癌组患者的五项指标中 PG玉尧PGR 均低于其他各组袁G-17 水平尧Hp-Ab 阳性率均高于其他各组袁差异有统计
关键词院胃疾病曰幽门螺杆菌抗体曰胃泌素 17曰胃蛋白酶原
中图分类号院R735.2
文献标识码院A
DOI院10.3969/j.issn.1006-1959.2018.11.007
文章编号院1006-1959渊2018冤11-0022-03
The Significance of Combined Detection of Helicobacter Pylori Antibody,Gastrin 17,
专题
医学信息 2018 年 6 月第 31 卷第 11 期
Medical Information. Jun. 2018. Vol. 31. No.11
幽门螺杆菌抗体、胃泌素 17、胃蛋白酶原等联合检测
在体检人群胃疾病筛查中的意义
茅溢恒
渊南京医科大学附属无锡人民医院体检中心袁江苏 无锡 214023冤
摘 要院目的 探讨分析幽门螺杆菌抗体尧胃泌素 17尧胃蛋白酶原玉尧域及 PGR 联合检测在体检人群胃疾病筛查中的意义遥方法
选取 2016 年 1 月~2017 年 12 月来我院体检中心选择同时包含胃镜尧胃泌素 17尧胃蛋白酶原及幽门螺杆菌抗体检查项目的受
检者 271 例袁分为经胃镜检查渊部分行活检病理冤证实的胃溃疡组 49 例袁萎缩性胃炎组 86 例袁癌前病变和胃癌组 36 例袁经胃镜
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学意义渊 约0.05冤遥 萎缩性胃炎组的 G-17 水平低于其他各组袁差异有统计学意义渊 约0.05冤遥 胃溃疡组中 G-17 和 Hp-Ab 阳性率
的结果与对照组比较袁差异有统计学意义渊 约0.05冤遥结论 幽门螺杆菌抗体尧胃泌素 17尧胃蛋白酶原玉尧域及 PGR 的阳性率与胃
疾病不同种类及严重程度密切相关袁其联合检测在体检人群胃疾病的筛查尧鉴别方面有着重要意义遥
Pepsinogen,etc.in Gastric Disease Screening in Physical Examination Population
MAO Yi-heng
(Physical Examination Center of Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi 214023,Jiangsu,China) Abstract：Objective To explore the significance of combined detection of Helicobacter pylori antibody,gastrin 17,pepsinogen I,II,and PGR in gastric screening for physical examination.Methods From January 2016 to December 2017,we selected 271 patients with gastroscope,gastrin 17,pepsinogen,and Helicobacter pylori antibody screening items from our physical examination center and were divided into gastroscopic examinations (partially biopsy pathology)confirmed 49 cases of gastric ulcer group,86 cases of atrophic gastritis group,36 cases of precancerous lesion and gastric cancer group,and 100 cases of gastroscopic examination without gastric disease or superficial gastritis in the control group.The radioimmunoassay was used to determine the levels of Helicobacter pylori antibody, gastrin 17,pepsinogen I,II and its ratio in the serum of the physical examination population.At the same time,gastroscopy and endoscopic biopsy were all based on pathological diagnosis.Serological and gastroscopy were used and pathological results were analyzed statistically.Results The PGI and PGR in the five indicators of gastric precancerous lesions and gastric cancer patients were lower than those in other groups.The levels of G-17 and Hp-Ab positive were higher than those in other groups,and the difference was statistically significant( <0.05).The level of G-17 in atrophic gastritis group was lower than that in other groups,and the difference was statistically significant ( <0.05).The positive rates of G-17 and Hp-Ab in gastric ulcer group were significantly different from those in the control group,the difference was statistically significant ( <0.05).Conclusion The positive rate of Helicobacter pylori antibody, gastrin 17,pepsinogen I,II and PGR is closely related to the different types and severity of gastric diseases.The joint detection is of great significance in screening and identification of gastric diseases in the physical examination population. Key words：Gastric disease;Helicobacter pylori antibody;Gastrin 17;Pepsinogen