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药学英语第三版上册胡延熹课后翻译-推荐下载
Vitamins ---- Translation1.Researchers found that the level of vitamin C stored in the body of the victim with a common cold fell drastically and was close to the level of people suffering from scurvy.2.Minor degrees of vitamin C deficiency are common, though outright scurvy only occur when the diet is markedly deficient in fresh fruits and vegetables.3.Vitamins are organic compounds that must be supplied in the diet or injected into the body to maintain health.4.Vitamins produce no energy but play an essential role in the transformation of energy and in the regulation of metabolism.5.Vitamins are classified/distinguished by the letters of the alphabet, such as vitamins A, C, D, E, K and the B-complex.6.Vitamins and minerals are found in small amounts and are needed in minute quantities, as compared with the other nutrients.7.The diseases which develop from the absence of vitamins are known as vitamin deficiency diseases. For example, a lack of vitamin A brings about night blindness; a deficiency of vitamin D results in rickets.8.Some vitamins are soluble in fats whereas others are soluble in water. They are, therefore, termed fat-soluble and water soluble vitamins respectively.9.In addition to the general nutrients, another two groups of nutrients, vitamins and inorganic, or mineral, salts are also required by the body.10.Most nutrients contain more than one nutrient, but no single food contains all the nutrients in the amounts you need.食物抗癌1.Overwhelming statistical evidence shows that smokers are more likely to develop cancer of the lung, throat, and tongue than are non-smokers.2.Fruits and vegetables are chock-full of a variety of antioxidants which can snuff out oxygen free radicals, substances that are thought to make cells more susceptible to cancer.3.A well-balanced diet will give your body various nutrients of vitamins, minerals, proteins, starches, and sugars that it needs to operate smoothly.4.The risk of lung cancer is directly related to the number of cigarettes smoked each day--the higher the number, the higher the risk.5.Even smokers may be protected from developing lung cancer by a daily portion of carrots, spinach or any other vegetables and fruits.6.Some studies of animals and humans have suggested that vitamin A offers some protection against lung cancer.7.Further studies will be necessary before the link between lung cancer and carotene can be firmly established.8.Animal studies show that garlic blocks carcinogens that have been linked to colon and stomach cancer.9.A diet of more fruits and vegetables will undoubtedly play a major role in reducing cancer incidence as well as the number of deaths caused by the disease.10.Beta-carotene not only has a direct toxic effect on tumor cells, but also reduces the growth of lung-cancer cells and altered the proteins needed for tumors to grow.化学与物质----Translation1.Briefly speaking, a scientist differs from an artist mainly in that a scientist not only interprets the outer world, but also tries to transform it into a better one.2.Science begins with necessity, curiosity, and questions about the unexplained phenomena in nature.3.The ways in which an element or a compound combines or reacts with other things are its chemical properties.4.The chemist is interested in the composition and properties of substances and the transformations they undergo during a chemical reaction.5.It is very easy to fall into the habit of taking some painkiller when there is any slight pain.6.The delicate operations performed by surgeons today would not be possible without anesthetics.7.Today it is generally recognised that the human body is a chemical factory in which countless complex chemical and physicalchanges are constantly taking place.8.The substance salt is composed of the metal sodium and the corrosive gas chlorine, but its chemical properties are quite different from those of sodium and chlorine.9.Chemotherapy is the treatment of disease by the administration of chemical substances which kill or prevent the growth of pathogenic organisms within the body.10.Substances that lessen pain but do not affect other sensations are called pain relieving drugs.麻醉药Translation1.It is not many years since a man who had to have an operation felt all its pain.2.It is attributable to the discovery of anesthetics that surgeons can now perform all kinds of operations without causing pain.3.Spinal anesthesia produces excellent anesthesia and relaxation for the performance of many operations on the lower parts of the body.4.The exact mechanism in which the general anesthetic drugs exert their effect on the brain is still unknown, although many theories have been proposed.5.The introduction of anesthetics to surgery has made possible much more delicate and lengthy operations, thus greatly extending the field of surgery.6.Narcotics are applied to those drugs which are sedative in their action upon the body but which also produce insensibility to pain.7.Contrary to what one might think, it’s only 50 years or so since penicillin, the antibiotic once regarded as the wonder drug, came into being.8.Scientists point out that since the sedative action of a drug results from its effect on the nerves, it must possess solubility in the fluids of the body which surround the nerves.9.An anesthetic must be volatile if it is to be administered through oral inhalation, while those which can be administered through the rectum or injected into the spine do not have to be volatile.10.In spite of the danger of a patient’s contracting pneumonia after the use of ether as an anesthetic, ether is still widely employed because the anesthesia it produces is one of deep relaxation.绿色药房-草药Translation1.The plant kingdom was once man’s only pharmacy. Yet when you enter a modern chemist’s shop today, you can hardly find a sign of the use of plants in medicine.2.Today the number of plants used in medicine has decreased, but hidden away in many pills, capsules, and medicine bottles are the active chemicals originally found in the plant kingdom.3.Some chemicals which plants make may be poisonous, others may be chemicals that are extremely valuable to us as medicines.4.During the many thousands of years that man has been on the earth, he has been trying out various plants that grew around him.5.There has existed for many years mistrust, suspicion or hostility between the orthodox and the herbal practitioner which threatens the possibility of a good working relationship.6.When one considers the therapeutic impact of quinine, it is evident how great is the debt of medicine to plant-derived drugs.7.However, the past few decades have witnessed an obvious diminution in the number of plant-derived drugs introduced into medicine.8.The legacy of traditional Chinese medicine is a treasure house with an inexhaustible supply of new potential drugs which is to be explored with an introduction of new approaches.9.Had pharmacological approaches not been introduced into the investigation of Vinca rosea, the discovery of vincalcukoblastine would have been postponed by many years.10.Western practitioners find it difficult to believe that someone who knows nothing of a disease mechanism could still be capable of curing it.Natural Products1. One of the oldest of human activities is the study of plants and animals, particularly as sources of food.2.From the earliest times man had to distinguish between those plants which were poisonous and those which were not and there graduall y developed a knowledge of natural drugs.3. As late as the beginning of the present century pharmacognosy had developed mainly on the botanical side, being particularly concerned with the description and identification of drugs.4.Undoubtedly the plant kingdom still holds many species of plants containing substances of medical value which have yet to be discover ed.5. As a result of modern isolation and pharmacological testing procedures, new plant drugs usually find their way into medicine as purified substances.6. Many of the botanical, chemical and physical techniques employed in pharmacognosy are also applicable to the analysis of other comm odities, such as foods, spices and cosmetics.7. While pharmacognosy has been generally studied for practical purposes and may thus be called an applied science it has played an imp ortant role in the development of the pure sciences.8. Recent phytochemical examination of plants which have a suitable history of use in folklore for the treatment of cancer has, indeed, oft en resulted in the isolation of principles with antitumour activity.9. The growth of knowledge of biochemistry and physiology, which led to the concept of the chemical control of biological processes, has been of particular importance for pharmacology.10. Primitive man depended on preventive use of nature’s stock of plants and herbs to avoid disease and to maintain health and vigor.有机化学Translation1. The remarkable advances made in modern medicine would not have been possible without the aid of chemistry.2. Since the body is essentially a chemical machine, a knowledge of the chemistry of bodily functions seems essential to the physician.3. The production of food by plants and animals involves the rearrangement of atoms in molecules.4. Fortunately, few kinds of work seem to urge people on to success more effectively than does the pursuit of chemistry.5. So far the motive behind the search for synthetics has been a wish to produce better things for less money, and for more people.6. Isolation of increasing numbers of purified materials from living forms and recognition of the fact that all contained carbon gave birth to organic chemistry.7. When coal is burned in a furnace it combines with oxygen to give carbon dioxide, a new substance with different composition and properties from coal and oxygen.8. Many specific chemical reactions are important because of the energy which they use or supply.9. In the study of organic chemistry, students are expected to use familiar symbols which are constructed into two- or three-dimensional molecular formulas.10.From the food we eat, the clothes we wear to the buildings we live in, all have been fashioned to a considerable extent by organic chemistry.新药研制1Translation1.Formerly, drugs were extracted from natural plants and animal sources, and therapeutic use was based on traditional experience.2.Drug development strategies involve serendipity, molecular roulette, programmed basic research with synthesis of specific chemical, etc..3.Though it’s the most satisfying in the development of new drugs, the approach is expensive and there is no guarantee of success.4.When a drug is used by millions, there are certain to be adverse reactions even though the risk to any individual is small.5.Most drugs have a safe upper limit of dosage; beyond this toxic effects may be expected to occur.6.Penicillin, one of the most powerful killers of bacteria was discovered quite by accident by Alexander Fleming.7.Pharmacological experiment on a new drug determines whether the drug has the desired profile of action in model system.8.The increase in knowledge of biochemical mechanisms results in a more rational approach to the development of new drugs.9.Extensive formal toxicological tests are required before a new drug can be used on patients.10.Chemists and biologists have now attached great importance to such fields of research as molecular biology and biochemicalpharmacology.新药研制 2 Translation1.The rationale for the development of new drugs should be provide better drugs; better in the sense of being either more effective, safer or cheaper.2.The representative of the pharmaceutical manufacturer has been specially trained to promote his particular new product.3.Only after animal studies have proved efficacy can clinical evaluation of new drugs be undertaken.4.New drug evaluation in man can be divided into four phases each of which should be conducted under strict supervision.5.A dose-ranging study should only be performed on volunteers who are informed about the implications of the tests, and who give their consent freely.6.Dose-ranging studies should only be performed under medical supervision, as there exist some possible risks during the test.rge scale clinical trials in Phase 3 are to establish new drug’s profile of action and frequency of adverse effects.8.The expensive cost in drug development is borne by the pharmaceutical manufacturer, which justifiably expects to recoup it when the product is finally marketed.rmation about the new drug published in well-established journals is more reliable than that offered by the medical representative whose livelihood depends on the ability to promote the product.10.Heavy investment in promotion has not simply led to the use of undistinguished new drugs, but to a higher cost of the drugs as well.药理学范畴Translation1.The science of the effects of drugs on the body is called pharmacology, and the scientists who study it are pharmacologists.2.Pharmacology is not a science that can be studied on its own, but that closely related to other branches of science.3.Pharmacologists should not only understand the normal processes that take place in the body, but know how the functions of the body are affected by disease.4.Properly used, drugs are great blessing to mankind; improperly used, they could destroy the race.5.During the first part of the twentieth century there have been enormous strides in the field of pharmacology.6.Man continues to strive, not only for a longer life span, but for a healthier one as well.7.With the frequent use of more than one therapeutic agent by a patient, particularly the elderly, drug interactions that result in toxicity are likely events.8.The clinician is interested primarily in drugs that are useful in the prevention, diagnosis, and treatment of human diseases.9.Most of the natural drugs are now highly purified and differ little from synthetic chemicals, the interests of the clinician in pharmacognosy are correspondingly decreased.10.As a border science, pharmacodynamics borrows freely from both the theories and experimental techniques of physiology, biochemistry, immunology, pathology, etc..良药滥用-----Translation1.Although the development of antibiotics has been of incalculable benefit to mankind, it has also given rise to serious complications.2.The widespread use of antibiotics has resulted in the natural evolution of strains of disease germs which are resistant to such medications.3.A new multidrug-resistant tuberculosis, now prevalent in the world, causes serious infections that may not respond to chemotherapy.4.Some antibiotics are effective against a large range of microorganisms, they are, therefore, known as broad-spectrum antibiotics.5.Some drugs may not cause physical dependence, or addiction, but many persons do become habituated to their use.6.Drug abuse is thought of as the misuse of drugs potentially harmful to the individual user or to society.7.Many persons, believing that antibiotics can cure any disease, press their doctors for a dose of penicillin for such virus ailment as influenza.8.Addiction is the body’s continued need for drugs because of their physiological effects after they are first taken.9.In comparison, the inadequacies and potential dangers of antibiotics are much less widely known.10.Antibiotics are used so carelessly around the world that they are creating a new health threat to mankind.抗癌的食物（全文翻译）现在饮食开始被考虑作为抵抗癌症的主要武器。
药学英语第五版原文翻译.doc
Introduction to PhysiologyIntroductionPhysiology is the study of the functions of living matter. It is concerned with how an organism performs its varied activities: how it feeds, how it moves, how it adapts to changing circumstances, how it spawns new generations. The subject is vast and embraces the whole of life. The success of physiology in explaining how organisms perform their daily tasks is based on the notion that they are intricate and exquisite machines whose operation is governed by the laws of physics and chemistry.Although some processes are similar across the whole spectrum of biology—the replication of the genetic code for or example—many are specific to particular groups of organisms. For this reason it is necessary to divide the subject into various parts such as bacterial physiology, plant physiology, and animal physiology.To study how an animal works it is first necessary to know how it is built. A full appreciation of the physiology of an organism must therefore be based on a sound knowledge of its anatomy. Experiments can then be carried out to establish how particular parts perform their functions. Although there have been many important physiological investigations on human volunteers, the need for precise control over the experimental conditions has meant that much of our present physiological knowledge has been derived from studies on other animals such as frogs, rabbits, cats, and dogs. When it is clear that a specific physiological process has a common basis in a wide variety of animal species, it is reasonable to assume that the same principles will apply to humans. The knowledge gained from this approach has given us a great insight into human physiology and endowed us with a solid foundation for the effective treatment of many diseases.The building blocks of the body are the cells, which are grouped together to form tissues. The principal types of tissue are epithelial, connective, nervous, and muscular, each with its own characteristics. Many connective tissues have relatively few cells but have an extensive extracellular matrix. In contrast, smooth muscle consists of densely packed layers of muscle cells linked together via specific cell junctions. Organs such as the brain, the heart, the lungs, the intestines, and the liver are formed by the aggregation of different kinds of tissues. The organs are themselves parts of distinct physiological systems. The heart and blood vessels form the cardiovascular system; the lungs, trachea, and bronchi together with the chest wall and diaphragm form the respiratory system; the skeleton and skeletal muscles form the musculoskeletal system; the brain, spinal cord, autonomic nerves and ganglia, and peripheral somatic nerves form the nervous system, and so on.Cells differ widely in form and function but they all have certain common characteristics. Firstly, they are bounded by a limiting membrane, the plasma membrane. Secondly, they have the ability to break生理学简介介绍生理学是研究生物体功能的科学。
药学英语(化学工业出版社)课文翻译
药学英语课文翻译Unit1药品依据他们的产品或来源药物能够被分为三种：Ⅰ、全合成Ⅱ、天然产物和Ⅲ、由局部合成产物〔半合成产物〕本书的重点是关于最重要化合物Ⅰ和Ⅲ——这类药物合成。
然而，这并不意味天然产物和其他的药物就不重要。
它们能够被用作有价值的先导化合物，同时它们通常被用作起始原料或作为重要合成产物的中间体。
而更加经济的。
在过往的几年里发酵，即微生物工程，差不多变得极其重要。
通过现代技术和基因的选择结果，导致了微生物高突变体演变的产生，发酵差不多变成了对物质广泛围的选择方式。
真核细胞〔酵母和霉菌〕和原核细胞〔单细菌细胞和放线菌〕都被用作微生物。
以下为可获得的生产形式:1.细胞原料〔单细胞蛋白质〕2.酶3.初级的落解产物〔初级酶代谢物〕4.次级的落解产物〔次级的代谢物〕在次级代谢物中，必先提起的是抗生素，以下五种药代表了每年世界范围内价值170亿美元的药物：青霉素，头孢菌素，四环素，红霉素，氨基糖苷类。
大约有5000种抗生素差不多从微生物中不离出来了，但在这些中仅有那些少于100种用于治疗使用。
然而，一定明白，那些衍生物通过局部合成被先进用于治疗。
在过往十年中，单单从β-内酰胺半合成的就有五万种药物。
发酵在容积大于400m3的不锈钠发酵罐中进行，防止了微生物噬菌体的污染等等，整个过程必须在无菌条件下进行。
〔倒数第五段开始〕大量使用的试剂不仅仅是酸〔盐酸、硫酸、硝酸、醋酸〕，还有无机和有机碱〔氢氧化钠、氢氧化钾、碳酸钾、重碳酸钾、铵碱、三乙胺、吡啶〕。
还有辅助化学物质包括活性炭和催化剂。
所有这些补充的化学物质〔比方中间体〕在最终产物中可能是杂志的来源。
在1969年，世界卫生组织出版了关于“药品平安质量保卫〞的论述。
名目2是有关“药品赔偿和平安保卫质量的规定〞〔世界卫生组织，1969年第418号技术报告，名目2；1975年第567号名目1A〕这同时变为众所周知的“药品质量治理标准〞或GMP标准，同时这些规定在现在药品生产中也应遵守。
(完整版)药学英语第五版原文翻译
Introduction to PhysiologyIntroductionPhysiology is the study of the functions of living matter. It is concerned with how an organism performs its varied activities: how it feeds, how it moves, how it adapts to changing circumstances, how it spawns new generations. The subject is vast and embraces the whole of life. The success of physiology in explaining how organisms perform their daily tasks is based on the notion that they are intricate and exquisite machines whose operation is governed by the laws of physics and chemistry.Although some processes are similar across the whole spectrum of biology—the replication of the genetic code for or example—many are specific to particular groups of organisms. For this reason it is necessary to divide the subject into various parts such as bacterial physiology, plant physiology, and animal physiology.To study how an animal works it is first necessary to know how it is built. A full appreciation of the physiology of an organism must therefore be based on a sound knowledge of its anatomy. Experiments can then be carried out to establish how particular parts perform their functions. Although there have been many important physiological investigations on human volunteers, the need for precise control over the experimental conditions has meant that much of our present physiological knowledge has been derived from studies on other animals such as frogs, rabbits, cats, and dogs. When it is clear that a specific physiological process has a common basis in a wide variety of animal species, it is reasonable to assume that the same principles will apply to humans. The knowledge gained from this approach has given us a great insight into human physiology and endowed us with a solid foundation for the effective treatment of many diseases.The building blocks of the body are the cells, which are grouped together to form tissues. The principal types of tissue are epithelial, connective, nervous, and muscular, each with its own characteristics. Many connective tissues have relatively few cells but have an extensive extracellular matrix. In contrast, smooth muscle consists of densely packed layers of muscle cells linked together via specific cell junctions. Organs such as the brain, the heart, the lungs, the intestines, and the liver are formed by the aggregation of different kinds of tissues. The organs are themselves parts of distinct physiological systems. The heart and blood vessels form the cardiovascular system; the lungs, trachea, and bronchi together with the chest wall and diaphragm form the respiratory system; the skeleton and skeletal muscles form the musculoskeletal system; the brain, spinal cord, autonomic nerves and ganglia, and peripheral somatic nerves form the nervous system, and so on.Cells differ widely in form and function but they all have certain common characteristics. Firstly, they are bounded by a limiting membrane, the plasma membrane. Secondly, they have the ability to break down large molecules to smaller ones to liberate energy for their activities.生理学简介介绍生理学是研究生物体功能的科学。
2012药学英语翻译
Unit 1 Green pharmacy-herbal medicine1) Plant kingdom once was mere pharmacy of the human race, but now when you get into the modern pharmacy, plant-derived drugs have been hardly found.2) Although today the number of plant-based drugs has been decreased, the effective chemicals in many tables, capsule and bottle-contained drugs are originated from plant kingdom.3) Among chemical substances contained in plants, some must be toxic, but some must be drugs available to us.4) During the millions of years since man came to the earth, he has been doing experiments on a variety of plants about him.5) There exist mistrust, suspicion and hostility between the orthodox medicine and herbal practitioners for many years, which are threatening the possibility of establishing good working relationship.6) When we think of the effectiveness of quinine, the great contributions made by herbal medicine to medical science are quite evident.7) However, in the past few decades, the number of newly-introduced drugs has obviously decreased.8) The medical legacy of our motherland is an inexhaustible new-drug treasure, which remains us to tap with new methods.9) If pharmacological method had not been introduced to the study of vinca rosea, the discovery of vincaleukoblastine would have been postponed by many years.10) Western medicine hardly believes that someone who knows nothing of a disease mechanism could be capable of curing it.Unit 2 How does human body fight disease?People tend to believe that antibiotics were invented by human being, but in fact, they are purely natural products. Since Alexander Fleming, a British biologist discovered anti-microbial substance released by the Penicillium fungi in 1928, it has been learned that this substance can produce powerful antibiotic effect. In fact, antibiotics, are exactly manufactured by organisms, namely, bacteria and fungi, which people aim to destroy. After Fleming’s discovery of penicillin, Selma Walksman in 1943 isolated Streptomycin from a soil bacterium, Streptomycus griseus. Scientists have not made it clear completely why organisms can produce antibiotics. This question has become the topic for discussion.Why antibiotics are useful in medicine is that they can not only kill microbes, but also not kill the body cells as they do to the microbes, body cells are entirely different from those of bacteria cells, so that they can avoid being destroyed at the same time. Thus, antibiotics are called “magic bullet”because they may be particularly used to aim at certain microbes. This feature of antibiotics also makes them essentially different from anti-microbial agents: the latter tends to have poison to a majority of cells, whether the cells of bacteria or the body cells.Unit 3 Drug dependenceStudies indicate that drug dependencies both a health problem and a social concern. The drug dependence affects not only individual’s health but also the public health at the same time. The drug use has obviously and severely negative effects on the human brain and physical health. But drug abuse and addiction have huge and potential threat, because whether the drug is used directlyor indirectly has become the main transmitting ways for many severe communicable diseases, AIDS, hepatitis and pulmonary tuberculosis in particular, plus violent behaviors, etc. The drug addiction is such a complicated and widely health-associated problem that we must duty-boundly put the measures about the public health, extensively-launched education, prevention, treatment and scientific research into our total strategy. Science is offering the foundation to the exploration of public health, which keeps the opposite attitude to the extensively-accepted point of view. It thinks that the drug dependents are made to lose all abilities by drugs, so they cannot rectify their own behaviors. It also offers the suggestions of the foundation for revising the total strategy, so as to reduce the negative effects produced by injection of drugs on the individual and society.Unit 4 The scope of pharmacology1) The science that drugs act on the human body is known as pharmacology, while the scientists who studies this science is called pharmacologist.2) Pharmacology is not a science which can be studied alone, but one that is closely related to other sciences.3) Pharmacologist should not only learn the normal reaction process, but also know how the functions of the human body are affected by diseases.4) If the drug is properly used, it will be a boon to the human race, if not, it will destroy the human race.5) In the first half of the 20th century, the fantastic development has been achieved in the pharmacological field.6) The human race makes constant efforts not only for increasing life expectancy, but also for more healthy life.7) If a patient, the old in particular, constantly uses more than one therapeutic agent, the correlation of the drugs causing toxin tends to occur.8) The clinician is interested primarily in the drugs that are useful in the prevention, diagnosis, and treatment of human disease.9) As most of the natural drugs are now highly purified and differ little from synthetic chemical drugs, the interests of the clinicians in pharmacognosy are correspondingly limited.10) Pharmacodynamics, as a border science, borrows greatly from both the subject matter and the experimental techniques of physiology, biochemistry, microbiology, immunology, genetics, pathology and so on.Unit 5 Combinatorial chemistry and new drugs1) To fight against disease, the immune system generates proteins known as antibodies that bind to invading organisms. But the real case is that the immune system is not to develop a specialized antibody each time it is faced with a new pathogen. In fact, the immune system select the most effective one by mass screening of its antibody repertoire, thus identifying the ones that work best.2) In a process called combinatorial chemistry, chemicals generate a large number of related compounds and then screen the collection for the ones that could have medicinal value.3) In a parallel synthesis, chemists often use a so-called microtiter plate to assemble all the products separately in their own reaction vessels.4) A parallel synthesis and a split-and-mix synthesis are different with that in a parallel synthesis, all the products are assembled separately in their own reaction containers, while in a split-and-mixsynthesis, the related compound are mixed up in the same reaction vessel, which reduces the number of containers required.5) At the end of a split-and-mix synthesis, all the molecules attached to a single bead are found to be of the same structure. Chemists pull out from the mixture the beads that bear biologically active molecules and then, use sensitive detection techniques to determine the molecular makeup of the compound attached.Unit 6 Drug discovery and natural products1) Plant natural products have had, and continue to have, an important role as medicinal and pharmaceutical agents, not only as purified isolates and extractives, but also as lead compounds for synthetic optimization.2) Plant secondary metabolites also show promise for cancer chemoprevention, which has been defined as “the use of non-cytotoxic nutrients or pharmacological agents to enhance intrinsic physiological mechanisms that protect the organism against mutant clones of malignant cells”.3) Nevertheless, the vast majority of the world’s quarter of a million plant species has not been evaluated in pharmaceutical screens, and the small percentage that has been tested has generally been screened for activity against only a few therapeutic targets.4) Although many sampling programs designed to generate large numbers of samples for high-throughput screening programs have been characterized as random, it has been shown that they are neither truly random nor haphazard, but that sampling occurs without preconceived selection of species.5) Three main research approaches are used in drug discovery and development processes：（1）bioactivity- or mechanism of action directed isolation and characterization of active compounds, (2)rational drug design-based modification and analog synthesis, and (3)mechanism of action studies.Unit 7 New drugs and drug delivery systems1) Every drug has its innate pharmacological characteristics. With the right dosage, frequency of administration and route of administration, most patients can get the expected pharmacological eficacy.2) But to different patients, there may be certain ,or even very obvious differences. Patients’physique, quality of drug, microorganisms and environmental factors can all affect drug fuctioning. They can enhance or decrease drug efficacy.3) The main factors that produce individual differences are the differences in drug absorption, distribution, biotransformation and elimination.4) In order to achieve the goal of maximum efficacy and minimum side effect for every patient, it is far from enough just to select drugs according to their pharmaceutical functioning.5) Other factors that influence the efficacy of different drugs must be taken into account, and appropriate therapies should be made according to the particular conditions of different patients. These therapies must be adjusted in time in the course of treatment to conform to patients’changed conditions until they recover.Unit 8 What analytical chemists do ?1) Analytical chemistry aims to resolve two questions:what it is and how much it is, that isqualitative analysis and quantitative analysis. Qualitative analysis is to identify the elements, ions and compounds contained in a sample while quantitative analysis is to determine the exact quantity.2) Analytical chemistry has expanded beyond the bounds of just chemistry, and many have advocated using the name analytical science to describe the field. Even this term falls short of recognition of the role of instrumentation development and application. One suggestion is that we use the term analytical science and technology.3) Analytical chemists work to improve the reliability of existing techniques to meet the demands for better chemical measurements which arise constantly in our society. They adopt proven methodologies to new kinds of materials or to answer new questions about their composition and their reactivity mechanisms.4) Qualitative tests may be performed by selective chemical reactions or with the use of instrumentation. For example, the formation of a white precipitate when adding a solution of silver nitrate to a dissolved sample indicateds the presence of chloride. Infrared spectra will give “fingerprints” of organic compounds or their functional groups.5) The first phase in the testing of banned substances is called fast-screening phase, in which qualitative analysis such as GC or LC is adopted to test suspicious samples. In the second phase, GC-MS is employed for further testing of those suspicious samples. Finally, spectrophotometry or GC is applied for accurate quantification.Unit 9 Nonclinical development of biopharmaceuticals1) The development of a new therapeutic agent involves a multidisciplinary group in many years of work, and with the development of genetic engineering and the production of monoclonal antibodies, it is likely that even more agents should be produced.2) The activity of biopharmaceuticals depends on their complicated conformation based on secondary, tertiary and quaternary structures. These structures cannot be fully defined with our present set of analytical techniques and approaches for potency testing.3) Apart from the intravenous route of drug administration, where a drug is introduced directly into the blood circulation, all other routesof adminstering systemically acting drugs involve the absoption of drug from the place of adminstration into the blood.4) Biopharmaceuticals are pharmaceutical products consisting of (glyco)proteins, and they have a number of characteristics that set them aside from low molecular weight drugs.5) In safety testing and clinical test programs of biopharmaceuticals, questions have to be addressed regarding species specific responses, selection of dosing schedules and route of administration, and the possible occurrence of immunogenicity.Unit 10 The package insert and prescription1) The information the package insert contains is derived from data supplied by investigators and submitted by pharmaceuticalfirm to the FDA, including the chemical structure of the drug, a summary of its pharmacological and toxicological action, its clinical indications and contraindications, precautions, reported adverse reactions, dosage recommendations, and available dosage forms.2) The physician may exercise his professional judgment in the use of any drug. However, if he deviates from the instructions in the package insert and adverse reactions occur, he must beprepared to defend his position in court if there is a malpractice suit.3) If a severe reaction occurred and litigation followed, how would a court react if a physician admitted to the use of this drug for the treatment of some diseases in view of the prohibitions in the package insert? Would the published clinical study, plus the physician’s judgment in prescribing the drug, suffice?4) The FDA cannot requirea pharmaceutical firm to include a new use for the drug product in the insert even if it has been clinically tested and found useful for a given problem. But, if a new use for a drug is not yet included in the package insert, the manufacturer cannot advertise his product for that particular use.5) Today, the FDA’s regulatory scope and authority include ensuring the safety and purity of foods, drugs, medical devices, nutritional supplements, vaccines and cosmetics. Of particular concern to the anesthesiologist is the timely access to drug evaluation, pharmacologic, and medical device data. With the dramatic upsurge in the number of new prescription drugs and over-the-counter supplements, the need for up-to-date drug information has never been more crucial.Unit 11 Development od new drugs(1)1) Formerly, drugs were extracted from natural plant and animal sources. Therapeutic use was empirical and based on traditional experiences.2) The strategies of the drug research include occasional discoveries, random molecular combination, and a planned research of synthesis of a certain specific chemical element.3) Although this is a ideal method of the development of new drugs, it is expensive and there is no guarantee of success.4) When a drug is used by millions of people, it is sure to develop unhealthy response, though this harm is not too big to particular people.5) Most drugs have a maximum safe dose, if the dose exceeds the limited extent, it will produce toxic side effects.6) Penicillin, one of the most powerful bacterium-killers in the world, was incidentally discovered by Fleming.7) The pharmacological experiment of a new drug will determine whether the drug has the desired medicinal functions in model systems.8) The addition of awareness of the biochemical mechanism will make the development of new drugs more rational.9) Extensive formal toxicological tests are required before new drugs can be used on patients.10) Now chemists and biologists attach importance to research fields of molecular biology, biochemical pharmacology, and so on.Unit 12 Development od new drugs(2)1) The rationale for the development of new drugs should be to provide better drugs, better in the sense of being either more effective, safer or cheaper.2) The promotion representative of the pharmaceutical manufacturer has been trained to promote a certain new product.3) The clinical evaluation of new drugs should be made after the study on animals proves effective.4) A new drug evaluation in man can be considered in four phases, each of which should be doneunder the strict supervision.5) Dose-ranging study should only be performed in volunteers who are informed about the implications of the tests, and who give their consent freely.6) As dose-ranging study may have a certain dangerous nature, it can only be carried out under medical supervision.7) A large scale of clinical trials in phase 3 will establish the new drug’s profile of action and frequency of adverse effects.8) The large cost of the drug development is borne by the pharmaceutical industry, which justifiably expects to recoupe it when the product is finally marketed.9) Information about new drugs published in well-established journals is more believable than the introductions by the representatives living on promotion.10) Heavy investment used in promotion of new drugs has not only led to the use of undistinguished new drugs but also raised the cost of the drugs.Unit 13 The impact of pharmaceutical care on drug therapy1) The focus of pharmaceutical care is to optimize drug therapy, minimize drug-related problems, and improve self-management for the purpose of achieving the optimal outcome to improve the patients’ quality of life.2) Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Ultimately, it is likely to lead to complications.3) The Pharmaceutical Care process for the patients in the Intervention Group consists of three sections. One of them is provided at hospital, then seamless care at the time of discharge from hospital and the last in the ambulatory setting.4) Pharmaceutical care has a clear benefit and positive impact on patient’s HRQoL, which is feasible in the hospital and in the community setting.5) The result of the study demonsreates that patients who do not receive intensified PC have a higher chance of deteriorationg their quality of life.Unit 14 FDA’s responsibilities and activities1) Before a new drug goes to the market and is widely used, the manufacturer should get the license from the corresponding authorized government agency(Drug Safety Commiittee in Britain; Food and Drug Administration in USA;Medical Products Agency in Sweden and etc).2) The new drug probably has been taken by more than 3000 healthy volunteers or patients in controlled studies before marketed unless it is only designed for some orphan diseases in small scale trials.3) At the present stage, most of the pharmacological effects are well-known and the side effects caused by overdosages have been documented. However, the recognition of unpredicted toxic and side effects are rarely known by humans until after the extensive use of the drugs.4) Continuous use of beta receptor blocking drug practolol for a comparative period of time may produce a syndrome of ocular mucosa and dermis, which had been discovered after several years.5) In similar manner, when thalidomide was discovered to make pregnant women who had taken the medicine during their early pregnancy bear babies with limb deformity, it had been sold on market for a few years.Unit 15 Good manufacturing practices(GMP)1) GMP is probably the most widespread quality system followed across the pharmaceutical industry as a whole. GMP compliance is a requirement within the R&D environment for the manufacture and testing of clinical trial materials (both drug product and API) and for commercial manufacture and testing of these materials.2) Although the FD&C Act requires all drugs (products and APIs) to be manufactured to cGMP, the regulations 21CFR parts 210 and 211 are only mandatory for the manufacture of drug products and not APIs. It is only with the issue of ICH Q7 A that the worldwide pharmaceutical industry finally received detailed guidance for manufacture of APIs for boh commercial and R&D purposes.3) There have been distinct and fundamental differences between USA regulation and EU/UK requirements for GMP. The US required all drugs to be made to GMP requirements and performed inspections throughout the world in support of these requirements. In the UK, only drug products and biological manufacturers (not APIs, except some specified antibiotics) were inspected by the regulatory authority fot compliance to GMP.4) An API is normally prepared by chemical processes and even if purification is involved at each stage of manufacture, impurities in APIs can not be removed thoroughly. Therefore, trace impurities are allowed to be present in drug product to a limited extent.5) Harmonization with the US through a Mutual Recognition Agreement（MRA）is seen as a big saving of inspection resources to both the EU and the USA, through mutual acceptance of API facility inspection reports.。
(完整版)药学英语第五版原文翻译
Introduction to PhysiologyIntroductionPhysiology is the study of the functions of living matter. It is concerned with how an organism performs its varied activities: how it feeds, how it moves, how it adapts to changing circumstances, how it spawns new generations. The subject is vast and embraces the whole of life. The success of physiology in explaining how organisms perform their daily tasks is based on the notion that they are intricate and exquisite machines whose operation is governed by the laws of physics and chemistry.Although some processes are similar across the whole spectrum of biology —the replication of the genetic code for or example specific to particular groups of organisms. For this reason it is necessary to divide the subject into various parts such as bacterial physiology, plant physiology, and animal physiology.To study how an animal works it is first necessary to know how it is built. A full appreciation of the physiology of an organism must therefore be based on a sound knowledge of its anatomy. Experiments can then be carried out to establish how particular parts perform their functions. Although there have been many important physiological investigations on human volunteers, the need for precise control over the experimental conditions has meant that much of our present physiological knowledge has been derived from studies on other animals such as frogs, rabbits, cats, and dogs. When it is clear that a specific physiological process has a common basis in a wide variety of animal species, it is reasonable to assume that the same principles will apply to humans. The knowledge gained from this approach has given us a great insight into human physiology and endowed us with a solid foundation for the effective treatment of many diseases.The building blocks of the body are the cells, which are grouped together to form tissues. The principal types of tissue are epithelial, connective, nervous, and muscular, each with its own characteristics.Many connective tissues have relatively few cells but have an extensive extracellular matrix. In contrast, smooth muscle consists of densely packed layers of muscle cells linked together via specific cell junctions. Organs such as the brain, the heart, the lungs, the intestines, and the liver are formed by the aggregation of different kinds of tissues. The organs are themselves parts of distinct physiological systems. The heart and blood vessels form the cardiovascular system; the lungs, trachea, and bronchi together with the chest wall and diaphragm form the respiratory system; the skeleton and skeletal muscles form the musculoskeletal system; the brain, spinal cord, autonomic nerves and ganglia, and peripheral somatic nerves form the nervous system, and so on.Cells differ widely in form and function but they all have certain common characteristics. Firstly, they are bounded by a limiting membrane, the plasma membrane. Secondly, they have the ability to break down large molecules to smaller ones to liberate energy for their activities.生理学简介介绍生理学是研究生物体功能的科学。
第四版药学英语课后翻译（节选）
第四版药学英语课后翻译（节选）药学英语课后翻译Organic Chemistry Translation1. 没有化学的帮助，现代医学所取得的令人瞩目的进展是不可能的。
The remarkable advances made in modern medicine would not have been possible without the aid of chemistry.2. 既然人体从本质上讲是一台化学机器，那么，有人体功能的化学知识对医生来说就显得至关重要了。
Since the body is essentially a chemical machine, a knowledge of the chemistry of bodily functions seems essential to the physician.3. 通过植物和动物生产食品涉及到分子中原子的重新排列问题。
The production of food by plants and animals involves the rearrangement of atoms in molecules.4. 幸运的是，很少有其他工作能像研究化学那样更能激励人们去取得成功。
Fortunately, few kinds of work seem to urge people on to success more effectively than does the pursuit of chemistry.5. 迄今为止，寻求合成制品背后的动机便是祈盼以更少的钱为更多的人生产更好的东西。
So far the motive behind the search for synthetics has been a wish to produce better things for less money, and for more people.6. 人们从活体分离出越来越多的纯净物质，并认识到它们都含有碳元素，这样便诞生了有机化学Isolation of increasing numbers of purified materials from living forms and recognition of the fact that all contained carbon gave birth to organic chemistry.7. 煤与氧结合在炉中燃烧，生成二氧化碳——一种在成分和化学性质上都不同于煤和氧的全新物质。
药学英语第五版原文翻译
Introduction to PhysiologyIntroductionPhysiology is the study of the functions of living matter. It is concerned with how an organism performs its varied activities: how it feeds, how it moves, how it adapts to changing circumstances, how it spawns new generations. The subject is vast and embraces the whole of life. The success of physiology in explaining how organisms perform their daily tasks is based on the notion that they are intricate and exquisite machines whose operation is governed by the laws of physics and chemistry.Although some processes are similar across the whole spectrum of biology—the replication of the genetic code for or example—many are specific to particular groups of organisms. For this reason it is necessary to divide the subject into various parts such as bacterial physiology, plant physiology, and animal physiology.To study how an animal works it is first necessary to know how it is built. A full appreciation of the physiology of an organism must therefore be based on a sound knowledge of its anatomy. Experiments can then be carried out to establish how particular parts perform their functions. Although there have been many important physiological investigations on human volunteers, the need for precise control over the experimental conditions has meant that much of our present physiological knowledge has been derived from studies on other animals such as frogs, rabbits, cats, and dogs. When it is clear that a specific physiological process has a common basis in a wide variety of animal species, it is reasonable to assume that the same principles will apply to humans. The knowledge gained from this approach has given us a great insight into human physiology and endowed us with a solid foundation for the effective treatment of many diseases.The building blocks of the body are the cells, which are grouped together to form tissues. The principal types of tissue are epithelial, connective, nervous, and muscular, each with its own characteristics. Many connective tissues have relatively few cells but have an extensive extracellular matrix. In contrast, smooth muscle consists of densely packed layers of muscle cells linked together via specific cell junctions. Organs such as the brain, the heart, the lungs, the intestines, and the liver are formed by the aggregation of different kinds of tissues. The organs are themselves parts of distinct physiological systems. The heart and blood vessels form the cardiovascular system; the lungs, trachea, and bronchi together with the chest wall and diaphragm form the respiratory system; the skeleton and skeletal muscles form the musculoskeletal system; the brain, spinal cord, autonomic nerves and ganglia, and peripheral somatic nerves form the nervous system, and so on.Cells differ widely in form and function but they all have certain生理学简介介绍生理学是研究生物体功能的科学。
(完整版)药学英语第五版原文翻译
conditions has meant that much of our present physiological knowledge
行了许多重要的生理调查，但是实验条件
has been derived from studies on other animals such as frogs, rabbits, cats, 需要精确控制，所以我们当前大多生理知
细胞在进化过程中不断分化进行不同
enzymes. During embryological development, this process of 的功能活动。 有些细胞具有收缩能力 （如肌
differentiation is re-enacted as many different types of cell are formed 细胞），有些可以传导电信号（如神经细
Thirdly, at some point in their life history, they possess a nucleus which
膜包被， 即细胞质膜； 第二， 细胞有把大分
contains genetic information in the form of deoxyribonucleic acid (DNA). 子分解为小分子来释放活动所需能量的能
nerves form the nervous system, and so on.
成呼吸系统；骨骼和骨骼肌组成骨骼肌系
Cells differ widely in form and function but they all have certain 统；大脑， 脊髓， 自主神经和神经中枢以及
common characteristics. Firstly, they are bounded by a limiting 周围躯体神经组成神经系统等等。
药学英语课后翻译
良药滥用-----Translation1. Although the development of antibiotics has been of incalculable benefit to mankind, ithas also given rise to serious complications.2. The widespread use of antibiotics has resulted in the natural evolution of strains ofdisease germs which are resistant to such medications.3. A new multidrug-resistant tuberculosis, now prevalent in the world, causes seriousinfections that may not respond to chemotherapy.4. Some antibiotics are effective against a large range of microorganisms, they are,therefore, known as broad-spectrum antibiotics.5. Some drugs may not cause physical dependence, or addiction, but many persons dobecome habituated to their use.6. Drug abuse is thought of as the misuse of drugs potentially harmful to the individualuser or to society.7. Many persons, believing that antibiotics can cure any disease, press their doctors for adose of penicillin for such virus ailment as influenza.8. Addiction is the body’s continued need for drug s because of their physiological effectsafter they are first taken.9. In comparison, the inadequacies and potential dangers of antibiotics are much lesswidely known.10. Antibiotics are used so carelessly around the world that they are creating a new healththreat to mankind.Vitamins ---- Translation1. Researchers found that the level of vitamin C stored in the body of the victim with acommon cold fell drastically and was close to the level of people suffering from scurvy.2. Minor degrees of vitamin C deficiency are common, though outright scurvy only occurwhen the diet is markedly deficient in fresh fruits and vegetables.3. Vitamins are organic compounds that must be supplied in the diet or injected into thebody to maintain health.4. Vitamins produce no energy but play an essential role in the transformation of energyand in the regulation of metabolism.5. Vitamins are classified/distinguished by the letters of the alphabet, such as vitamins A, C,D, E, K and the B-complex.6. Vitamins and minerals are found in small amounts and are needed in minute quantities,as compared with the other nutrients.7. The diseases which develop from the absence of vitamins are known as vitamindeficiency diseases. For example, a lack of vitamin A brings about night blindness; adeficiency of vitamin D results in rickets.8. Some vitamins are soluble in fats whereas others are soluble in water. They are,therefore, termed fat-soluble and water soluble vitamins respectively.9. In addition to the general nutrients, another two groups of nutrients, vitamins andinorganic, or mineral, salts are also required by the body.10. Most nutrients contain more than one nutrient, but no single food contains all thenutrients in the amounts you need.化学与物质----Translation1. Briefly speaking, a scientist differs from an artist mainly in that a scientist not onlyinterprets the outer world, but also tries to transform it into a better one.2. Science begins with necessity, curiosity, and questions about the unexplainedphenomena in nature.3. The ways in which an element or a compound combines or reacts with other things areits chemical properties.4. The chemist is interested in the composition and properties of substances and thetransformations they undergo during a chemical reaction.5. It is very easy to fall into the habit of taking some painkiller when there is any slightpain.6. The delicate operations performed by surgeons today would not be possible withoutanesthetics.7. Today it is generally recognised that the human body is a chemical factory in whichcountless complex chemical and physical changes are constantly taking place.8. The substance salt is composed of the metal sodium and the corrosive gas chlorine, butits chemical properties are quite different from those of sodium and chlorine.9. Chemotherapy is the treatment of disease by the administration of chemical substanceswhich kill or prevent the growth of pathogenic organisms within the body.10. Substances that lessen pain but do not affect other sensations are called pain relievingdrugs.麻醉药Translation1. It is not many years since a man who had to have an operation felt all its pain.2. It is attributable to the discovery of anesthetics that surgeons can now perform all kindsof operations without causing pain.3. Spinal anesthesia produces excellent anesthesia and relaxation for the performance ofmany operations on the lower parts of the body.4. The exact mechanism in which the general anesthetic drugs exert their effect on thebrain is still unknown, although many theories have been proposed.5. The introduction of anesthetics to surgery has made possible much more delicate andlengthy operations, thus greatly extending the field of surgery.6. Narcotics are applied to those drugs which are sedative in their action upon the body butwhich also produce insensibility to pain.7. Contrary to what one might think, it’s only 50 years or so since penicillin, t he antibioticonce regarded as the wonder drug, came into being.8. Scientists point out that since the sedative action of a drug results from its effect on thenerves, it must possess solubility in the fluids of the body which surround the nerves.9. An anesthetic must be volatile if it is to be administered through oral inhalation, whilethose which can be administered through the rectum or injected into the spine do nothave to be volatile.10. In spite of the danger of a patient’s contractin g pneumonia after the use of ether as ananesthetic, ether is still widely employed because the anesthesia it produces is one ofdeep relaxation.绿色药房-草药Translation1. The plant kingdom was once man’s only pharmacy. Y et when you enter a modernchemist’s shop today, you can hardly find a sign of the use of plants in medicine.2. Today the number of plants used in medicine has decreased, but hidden away in manypills, capsules, and medicine bottles are the active chemicals originally found in theplant kingdom.3. Some chemicals which plants make may be poisonous, others may be chemicals that areextremely valuable to us as medicines.4. During the many thousands of years that man has been on the earth, he has been tryingout various plants that grew around him.5. There has existed for many years mistrust, suspicion or hostility between the orthodoxand the herbal practitioner which threatens the possibility of a good workingrelationship.6. When one considers the therapeutic impact of quinine, it is evident how great is the debtof medicine to plant-derived drugs.7. However, the past few decades have witnessed an obvious diminution in the number ofplant-derived drugs introduced into medicine.8. The legacy of traditional Chinese medicine is a treasure house with an inexhaustiblesupply of new potential drugs which is to be explored with an introduction of newapproaches.9. Had pharmacological approaches not been introduced into the investigation of Vincarosea, the discovery of vincalcukoblastine would have been postponed by many years.10. Western practitioners find it difficult to believe that someone who knows nothing of adisease mechanism could still be capable of curing it.有机化学Translation1. The remarkable advances made in modern medicine would not have been possiblewithout the aid of chemistry.2. Since the body is essentially a chemical machine, a knowledge of the chemistry ofbodily functions seems essential to the physician.3. The production of food by plants and animals involves the rearrangement of atoms inmolecules.4. Fortunately, few kinds of work seem to urge people on to success more effectively thandoes the pursuit of chemistry.5. So far the motive behind the search for synthetics has been a wish to produce betterthings for less money, and for more people.6. Isolation of increasing numbers of purified materials from living forms and recognitionof the fact that all contained carbon gave birth to organic chemistry.7. When coal is burned in a furnace it combines with oxygen to give carbon dioxide, a newsubstance with different composition and properties from coal and oxygen.8. Many specific chemical reactions are important because of the energy which they use orsupply.9. In the study of organic chemistry, students are expected to use familiar symbols whichare constructed into two- or three-dimensional molecular formulas.10. From the food we eat, the clothes we wear to the buildings we live in, all have beenfashioned to a considerable extent by organic chemistry.新药研制1Translation1. Formerly, drugs were extracted from natural plants and animal sources, and therapeuticuse was based on traditional experience.2. Drug development strategies involve serendipity, molecular roulette, programmed basicresearch with synthesis of specific chemical, etc..3. Though it’s the most satisfying in the development of new drugs, the approach isexpensive and there is no guarantee of success.4. When a drug is used by millions, there are certain to be adverse reactions even thoughthe risk to any individual is small.5. Most drugs have a safe upper limit of dosage; beyond this toxic effects may be expectedto occur.6. Penicillin, one of the most powerful killers of bacteria was discovered quite by accidentby Alexander Fleming.7. Pharmacological experiment on a new drug determines whether the drug has the desiredprofile of action in model system.8. The increase in knowledge of biochemical mechanisms results in a more rationalapproach to the development of new drugs.9. Extensive formal toxicological tests are required before a new drug can be used onpatients.10. Chemists and biologists have now attached great importance to such fields of researchas molecular biology and biochemical pharmacology.新药研制2 Translation1. The rationale for the development of new drugs should be provide better drugs; better inthe sense of being either more effective, safer or cheaper.2. The representative of the pharmaceutical manufacturer has been specially trained topromote his particular new product.3. Only after animal studies have proved efficacy can clinical evaluation of new drugs beundertaken.4. New drug evaluation in man can be divided into four phases each of which should beconducted under strict supervision.5. A dose-ranging study should only be performed on volunteers who are informed aboutthe implications of the tests, and who give their consent freely.6. Dose-ranging studies should only be performed under medical supervision, as there existsome possible risks during the test.7. Large scale clinical trials in Phase 3 are to establish new drug’s profile of action andfrequency of adverse effects.8. The expensive cost in drug development is borne by the pharmaceutical manufacturer,which justifiably expects to recoup it when the product is finally marketed.9. Information about the new drug published in well-established journals is more reliablethan that offered by the medical representative whose livelihood depends on the abilityto promote the product.10. Heavy investment in promotion has not simply led to the use of undistinguished newdrugs, but to a higher cost of the drugs as well.药理学范畴Translation1. The science of the effects of drugs on the body is called pharmacology, and the scientistswho study it are pharmacologists.2. Pharmacology is not a science that can be studied on its own, but that closely related toother branches of science.3. Pharmacologists should not only understand the normal processes that take place in thebody, but know how the functions of the body are affected by disease.4. Properly used, drugs are great blessing to mankind; improperly used, they could destroythe race.5. During the first part of the twentieth century there have been enormous strides in thefield of pharmacology.6. Man continues to strive, not only for a longer life span, but for a healthier one as well.7. With the frequent use of more than one therapeutic agent by a patient, particularly theelderly, drug interactions that result in toxicity are likely events.8. The clinician is interested primarily in drugs that are useful in the prevention, diagnosis,and treatment of human diseases.9. Most of the natural drugs are now highly purified and differ little from syntheticchemicals, the interests of the clinician in pharmacognosy are correspondingly decreased.10. As a border science, pharmacodynamics borrows freely from both the theories andexperimental techniques of physiology, biochemistry, immunology, pathology, etc..。
药学英语课文3翻译
Foods That Fight Cancer抗癌症的食物Foods That Fight CancerDiet is now considered a major weapon(武器) against cancer. The National Cancer Institute （协会）estimates that about one-third of all cancers are linked to diet, and recent research indicated（指出）that what you eat may help to significantly reduce your risk.Cancer develops over a long time, which means that you have years-typically decades（数十年）-in which to hinder（阻碍）or promote it. Researchers are finding that what you eat may interfere（妨碍）with cancer growth at various stages. For example, certain foods can block (v.阻碍) the chemicals that initiate（开始）cancer. Antioxidants（抗氧化剂）, found in some vitamins and minerals（矿物）, can snuff（消灭）out oxygen free radicals（基础；原子团）, substances that are thought to make cells more susceptible（易受影响的）to cancer, and they can even repair some of the cellular damage that has been done. And some food-wheat bran in particular-has been shown to shrink（收缩）precancerous（癌症前期的）cells.A recent review（评论）of 17 studies from 17 nations reveals that people who eat the most fruits and vegetables have about half the cancer rates of those who eat the least. That includes cancers of the lung, colon（结肠）, breast, cervix（宫颈）, esophagus（食道）, oral cavity（口腔）, stomach, bladder（膀胱）, pancreas（胰腺）and ovary（卵巢）. In fact, some research suggests that frequent consumption（肺痨;消耗）of fruits and vegetables can cut the risk of lung cancer even in smokers. “It is almost mind-boggling（难以理解的）,” says Tim Byers, an epidemiologist （流行病学家）with the U. S. Centers for Disease Control and Prevention, “that ordinary fruits and vegetables can be so effective against such a potent（有效的）carcinogen（致癌物质）as cigarette smoke.”One of the most studied antioxidants in vegetables and fruits thought to protect against cancer is beta-carotene（B-胡萝卜素）, concentrated（聚集）in deep green, yellow and orange vegetables such as carrots, sweet potatoes and spinach（菠菜）. Fruits high in beta-carotene include apricots （杏）and cantaloupes（哈密瓜）. In test-tube（试管）studies at Harvard University, beta-carotene had a direct toxic effect on cells taken from malignant（有害的）tumors（肿瘤）. It also reduced the growth of lung-cancer cells and altered（改变）the proteins needed for tumors to grow.Research also shows that beta-carotene can change in the body to retinoid acid（视黄酸）, a substance used in clinical trials to treat certain cancers.Here are some of the foods that contain cancer-fighting chemicals.Tomatoes. One of the compounds in tomatoes that is thought to reduce the risk of cancer is lycopene（番茄红素）, the pigment（色素）that makes tomatoes red. Lycopene, an antioxidant that is also found in watermelons and apricots, quenches（结束）certain cancer- triggering oxygen free radicals.Having little lycopene in your blood is associated with a higher risk of pancreatic cancer, according in a Johns Hopkins University study. People with pancreatic cancer showed lower levels of lycopene compared with healthy individuals. Those with the least blood lycopene had over five times the risk of pancreatic cancer as healthy people with the most blood lycopene.Lycopene is present in tomato products, including sauces（酱油）, tomato paste and even ketchup（番茄酱）.Green Vegetables. A recent Italian study showed that dark-green leafy vegetables lower the risk of many cancers. Spinach, broccoli（西兰花）, kale（甘兰）and dark-green lettuces（油麦菜）are chock-full of antioxidants, including beta-carotene, folate and lutein，. A good rule ofthumb: the darker the vegetable, the more antioxidants within.Citrus（柑橘类）Fruit. “Eat oranges, grapefruits（葡萄柚）, lemons and limes as often as possible,”says toxicologist Herbert Pierson, a former project officer with the National Cancer Institute. He calls citrus fruit an all-around cancer package because it possesses every class of natural substances (carotenoids（类胡萝卜素）, flavonoids（黄铜）and others) that individually have neutralized（中立的）powerful chemical carcinogens in animals.Citrus fruit may be particularly effective in reducing the risk of pancreatic cancer. One study found that in a group of Swedes, those who ate a citrus fruit almost daily reduced the risk of pancreatic cancer by one-half to more than two-thirds, as compared with eating citrus fruit less than once a week.Cruciferous（十字花科的）Vegetables. Cruciferous vegetables, such as cabbage, cauliflower, Brussels sprouts, broccoli, kale, mustard greens and turnips, may reduce the risk of breast cancer. In fact, researchers at Eppley Institute for Research in Cancer and Allied diseases at the University of Nebraska at Omaha found that feeding animals cabbage and collard greens (also a cruciferous vegetable), along with a low-fat diet, reduced the incidence（发病率）of mammary（乳腺癌）cancers. Eat cruciferous vegetables raw（生食）or lightly cooked. Overcooking may destroy the indoles（吲哚）, compounds found in these vegetables that may protect against cancer.Cruciferous vegetables may also work to head off stomach and colon cancer. Research conducted in Utah revealed（显示）that men who ate the most cruciferous vegetables had a 70 percent lower risk of colon cancer than those who ate the least of such vegetables.Soybeans. Soybeans contain at least five compounds believed to（抑制）cancer. In fact, one of the compounds is chemically similar to the drug tamoxifen （三苯氧胺）, which is routinely used to treat estrogen-dependent（雌性激素）breast cancer and is now being tested in a large clinical trial to see if it can prevent the disease. In animal studies, soybean constituents have been found to block colon, skin and other cancers by possibly slowing the growth and division（分割）of cancer cells.Wheat Bran. Wheat bran may lower the risk of colon cancer. A double-blind（双盲）study of patients at The New York Hospital-Cornell Medical Center found that two one-ounce servings of wheat bran cereal（谷类）a day caused premalignant colon polyps（息肉）to shrink within six months. Most remarkable, say researchers, is that such a small amount of food could have such an impact within a short period of time, illustrating（图解）that dietary intervention（饮食干预）may work even after precancerous warning signs have appeared.Low-Fat Milk. While the saturated（饱和的）fat in milk seems to promote certain cancers, another substance in milk may deter（阻止）them. Researchers at Roswell Park Cancer Institute in Buffalo, N. Y., discovered, not surprisingly, that drinkers of whole milk had higher odds than non-milk-drinkers of developing cancers of the oral cavity, stomach, colon, rectum, lung, bladder, breast and cervix. But they also found that those drinking low-fat milk were less likely than non-milk-drinkers to develop cancers of the oral cavity, stomach, rectum and cervix. Why? Scientists suspect（猜想）that elements（基础）such as calcium, riboflavin, or vitamins A, C, and D (present in whole milk, too, but apparently less effective) may act as anti-cancer agents in ways not yet understood.To get the most cancer-protective compounds from your diet, strive（努力）for five or more servings of fruits and vegetables daily, advises the National Cancer Institute. One serving means one-half cup of most cooked or raw fruits or vegetables, one cup of raw leafy vegetables, onemedium（半生的）piece of fresh fruit, or six ounces of fruit juice or vegetable juice. The ideal diet is low in fat and calories, high in fiber, and it includes a variety of nutrient-rich foods such as fruits, vegetables, whole grains, beans, seeds, nuts（坚果）and, if desired, low-fat animal proteins.翻译：抗癌的食物现在饮食开始被考虑作为抵抗癌症的主要武器。
药学英语第四版课后翻译
Unit One1.A full appreciation of the physiology of a living organism must be based on a sound knowledge of its anatomy. Anatomy does not merely study the separation of parts, but the accurate description of the morphologies and functions of different organs.2.Our daily food intake must match requirements and any excess must be excreted for balance to be maintained.3.The process of stabilization of the internal environment is called homeostasis and is essential if the cells of the body are to function normally.4.Human cells have the ability to break down large molecules to smaller ones to liberate sufficient energy for their activities.5.As long as normal conditions are maintained in this internal environment, the cells of the body continue to live and function properly.Unit Two1.Biochemistry asks how the thousands ofdifferent biomolecules interact with each other to confer the remarkable properties of living organisms.2.Enzymes are catalysts that accelerate the rates of biological reactions. Each enzyme is very specific in its foundation and acts only in a particular metabolic reaction.3.One of the most fruitful approaches to understand biological phenomena has been to purify an individual chemical component, such as protein, from a living organism and to characterize its chemical structure or catalytic activity.4.The chemical principles that govern the properties of biological molecules include the covalent bonding of carbon with itself and with other elements and the functional groups that appear in common biological molecules, etc.5.The basic unit of DNA is a linear polymer of four different monomeric subunits, deoxyribonucleotides, arranged in a precise linear sequence.Unit Four1.The science of the effects on the body is called pharmacology, and the scientists who study it are pharmacologists. Pharmacology is not a science that can be studied on its own, but that closely related to other branches of science. Pharmacologists should not only understand he normal processes that take place in the body, but know how the functions of the body are affected by disease.2.For physicians and medical students, the scope of pharmacology is not so expansive as its common definition. The clinician is interested primarily in drugs that are useful in the prevention, diagnosis, and treatment of human disease, or in the prevention of pregnancy.3.All physicians should share the responsibility to resolve kinds of sociological problems caused by the abuse of drugs. Properly used, drugs are great blessing to mankind; improperly used, they could destroy human race. When a patient, particular the elderly is prescribedfrequently to take more than one therapeutic agent, drug interactions resulting in toxicity will occur.4.At one time, it was essential for the physician to have broad botanical knowledge, because they had to possess the ability and skill to select proper plants from which to prepare his own crude medicinal preparation.5.The study of biochemical and physiological effects of drugs and their mechanisms of action is termed as pharmacodynamics, whose uniqueness lies mainly in that its attention is focused on the characteristics of the drug. As a broader science, it borrows freely from both the theories and experimental techniques of physiology, biochemistry, immunology, and pathology.Unit Five1.To fight against disease, the immune system generates proteins known as antibodies that bind to invading organisms. But the real case is that the immune system is not to develop aspecialized antibody each time it is faced with a new pathogen. In fact, the immune system select the most effective one by mass screening of its antibody repertoire, thus identifying the ones that work best.2.In a process called combinatorial chemistry, chemists generate a large number of related compounds and then screen the collection for the ones that could have medicinal value.3.In a parallel synthesis, chemists often use a so-called microtiter plate to assemble all the products separately in their own reaction vessels.4.A parallel synthesis and a split-and-mix synthesis are different with that in a parallel synthesis, all the products are assembled separately in their own reaction containers, while in a split-and-mix synthesis, the related compounds are mixed up in the same reaction vessel, which reduces the number of container required.5.At the end of a split-and-mix synthesis, all themolecules attached to a single bead are found to be of the same structure. Chemists pull out from the mixture the beads that bear biologically active molecules and then, use sensitive detection techniques to determine the molecular makeup of the compound attached.Unit Six1.Plant natural products has had, and continued to have, an important role as medicinal and pharmaceutical agents, not only as purified isolates and extractives, but also as lead compounds for synthetic optimization.2.Plant secondary metabolites also show promise for cancer chemoprevention, which has been defined as “the use of non-cytotoxic nutrients or pharmacological agents to enhance intrinsic physiological mechanisms that protect the organism against mutant clones of malignant cells.”3.Nevertheless,the vast majority of the world’s quarter of a million plant species has not been evaluated in pharmaceutical screens, and thesmall percentage that has been tested has generally been screened for activity against only a few therapeutic targets.4.Although many sampling programs designed to generate large numbers of samples for high-throughput screening programs have been characterized as random, it has been shown that they are neither truly random nor haphazard, but that sampling occurs without preconceived selection of species.5.Three main research approaches are used in drug discovery and development processes: (1) bio-activity or mechanism of action-directed isolation and characterization of active compounds, (2) rational drug design-based modification and analog synthesis, and (3) mechanism of action studies.Unit Seven1.Absorption is the process of a drug entering （现在分词作后置定语）systemic circulation from its site of administration. Except direct injection into the blood vessels, other routsof administration involve the transport of cell membrane.2.Drug absorption, especially those orally administered drugs, depends on many factors, such as the intrinsic characteristics of the drug, dosage form, food, patient age and the like.3.The distribution of a drug in the body is even and is in a state of dynamic equilibrium, that is, it changes constantly with the absorption and elimination of the drug.4.After a drug enters the blood, it will more or less bind to plasma protein, but this binding is loose and reversible, and is always in a state of equilibrium.5.Bioavailability is the relative quantity and rate of drugs with different dosage forms which are absorbed and reach the systemic circulation; it is concerned with the intensity and speed of drug action.Unit Eight1.Analytical chemistry aims to resolve twoquestions: what it is and how much it is, that is qualitative analysis and quantitative analysis. Qualitative analysis is to identify the elements, ions and compounds contained in a sample while quantitative analysis is to determine the exact quantity.2.Analytical chemistry has expanded beyond the bounds of just chemistry, and many have advocated using the name analytical science to describe the field. Even this term falls short of recognition of the role of instrumentation development and application. One suggestion is that we use the term analytical science and technology.3.Analytical chemists work to improve the reliability of existing techniques to meet the demands for better chemical measurements which arise constantly in our society. They adopt proven methodologies to new kinds materials or to answer new questions about their composition and their reactivity mechanisms.4.Qualitative test may be performed by selectivechemical reaction or with the use of instrumentation. For example, the formation of a white precipitate when adding a solution of silver nitrate to a dissolved sample indicates the presence of chloride. Infrared spectra will give “fingerprints” of organic compounds or their functional groups.5.The first phase in the testing of banned substance is called fast-screening phase, in which qualitative analysis such as GC or LC is adopted to test suspicious samples. In the second phase, GC-MS is employed for further testing of those suspicious samples. Finally, spectrophotometry or GC is adopted for accurate quantification.Unit Nine1. The development of a new therapeutic agent involves a multidisciplinary group in many years of work, and with the development of genetic engineering and the production of monoclonal antibodies, it is likely that even more agents should be produced.2. The activity of biopharmaceuticals depends on their complicated conformation based on secondary, tertiary and quaternary structures. These structures cannot be fully defined with our present set of analytical techniques and approaches for potency testing.3. Apart from the intravenous route of drug administration, where a drug is introduced directly into the blood circulation, all other routes of administering systemically acting drugs involve the absorption of drug from the place of administration into the blood.4. Biopharmaceuticals are pharmaceutical products consisting of (glyco) proteins, and they have a number of characteristics that set them aside from low molecular weight drugs.5. In safety testing and clinical test programs of biopharmaceuticals, questions have to be addressed regarding species specific responses, selection of dosing schedules and route of administration, and the possible occurrence of immunogenicity.Unit Eleven1) The information the package insert contains is derived from data supplied by investigators and submitted by pharmaceutical firm to the FDA, including the chemical structure of the drug, a summary of its pharmacological and toxicological action, its clinical indications and contraindications, precautions, reported adverse reactions, dosage recommendations, and available dosage forms.2) The physician may exercise his professional judgment in the use of any drug. However, if he deviates from the instructions in the package insert and adverse reactions occur, he must be prepared to defend his position in court if there is a malpractice suit.3) If a severe reaction occurred and litigation followed, how would a court react if a physician admitted to the use of this drug for the treatment of some diseases in view of the prohibitions in the package insert? Would the published clinical study, plus thephysician’s judg ment in prescribing the drug, suffice?4) The FDA cannot require pharmaceutical firm to include a new use for the drug product in the insert even if it has been clinically tested and found useful for a given problem. But, if a new use for a drug is not yet included in the package insert, the manufacturer cannot advertise his product for that particular use.5) Today, the FDA’s regulatory scope and authority include ensuring the safety and purity of foods, drugs, medical devices, nutritional supplements, vaccines and cosmetics. Of particular concern to the anesthesiologist is the timely access to drug evaluation, pharmacologic, and medical device data. With the dramatic upsurge in the number of new prescription drugs and over-the-counter supplements, the need for up-to-date drug information has never been more crucial.Unit Twelve1) Formerly, drugs were extracted from naturalplant and animal sources. Therapeutic use was based on traditional experiences.2) Drug development strategies involve serendipity, molecular roulette, programmed basic research with synthesis of specific chemical, etc.3) When a drug is used by millions, there are certain to be adverse reactions even though the risk to any individual is small.4) The pharmacological experiment on a new drug determines whether the drug has the desired profile in model system.5) Chemists and biologists have now attached importance to such fields of research as molecular biology and biochemical pharmacology.。
药学英语课本学习知识翻译课后翻译节选中英双语对照第四版
本篇包括人卫第四版Unit 3B，Unit4A，5A，8A，10A，12AB，13A等七篇课文Unit 3 Text B The Other Side of Antibiotics抗生素的另一面Antibiotics have eliminated or controlled so many infectious diseases that virtually everyone has benefited from their use at one time or another. Even without such personal experience, however, one would have to be isolated indeed to be unaware of the virtues, real and speculative, of these “miracle” drugs1. The American press, radio, and television have done a good job of reporting the truly remarkable story of successes in the chemical war on germs. What′s more, any shortcomings on their part have been more than made up for by the aggressive public relations activity of the pharmaceutical companies which manufacture and sell antibiotics.抗生素可以消除或控制很多种感染疾病，以致几乎每人生病时都习惯于使用它而受益，但是如果一个人没有这样的亲身经历，他必定是离群索居才会不知道这些“特效药物”或真实或推测的优点。
药学英语课文翻译 课后翻译节选 中英双语对照 第四版
本篇包括人卫第四版Unit 3B，Unit4A，5A，8A，10A，12AB，13A等七篇课文Unit 3 Text B The Other Side of Antibiotics抗生素的另一面Antibiotics have eliminated or controlled so many infectious diseases that virtually everyone has benefited from their use at one time or another. Even without such personal experience, however, one would have to be isolated indeed to be unaware of the virtues, real and speculative, of these “miracle” drugs1. The American press, radio, and television have done a good job of reporting the truly remarkable story of successes in the chemical war on germs. What′s more, any shortcomings on their part have been more than made up for by the aggressive public relations activity of the pharmaceutical companies which manufacture and sell antibiotics.抗生素可以消除或控制很多种感染疾病，以致几乎每人生病时都习惯于使用它而受益，但是如果一个人没有这样的亲身经历，他必定是离群索居才会不知道这些“特效药物”或真实或推测的优点。
药学英语课后翻译
药学英语课后翻译Unit 11. A full appreciation of the physiology of a living organism must be based on asound knowledge of its anatomy. Anatomy does not merely study the separationof parts, but the accurate description of the morphologies and functions ofdifferent organs.对⽣物⽣理学的全⾯了解必须基于解剖学的系统知识。
解剖学不仅仅是研究⼈体各部分的分离；还要准确的描述各个器官的形态和⽣理功能。
2. Our daily food intake must match requirements and any excess must be excretedfor balance to be maintained.我们每天摄⼊的事物必须满⾜需要；任何多余的东西必须排出体外才能维持平衡。
3. The process of stabilization of the internal environment is called homeostasis andis essential if the cells of the body are to function normally. 内环境稳定的过程称之为体内平衡；体内平衡也是机体的细胞正常发挥作⽤所必不可少的。
4. Human cells have the ability to break down large molecules to smaller ones toliberate sufficient energy for their activities.⼈类细胞有将⼤分⼦分解成⼩分⼦的能⼒；从⽽为⾃⾝活动释放⾜够的能量。
药学英语Unit14TextB注释及译文
药学英语Unit14TextB注释及译文Text B How Does FDA Approve New Drugs?Under current law, all new drugs need proof that they are effective, as well as safe, before they can be approved for marketing. But it’s important to realize that no drug is absolutely safe. There is always some risk of an adverse reaction. It’s when the benefits outweigh the risks that FDA considers a drug safe enough to approve.1.outweigh [a u tˊwe?] vt. 在重量上超过；在重要性或价值方面超过根据现行法规，对于所有新药，只有经确认安全、有效，才会被批准上市。
但是，我们应该意识到没有所谓绝对安全的药物，认识到这一点是很重要的。
任何药物都可能有不良反应。
因此，只有认定某种药物的益处大于其风险时，FDA 才会认为某种药物足够安全，可批准其上市。
In fact, it was only 25 years ago that U.S. drug law first embraced the idea of risk vs. benefit that now the key to new drugs approval. Providing evidence of safety before marketing was first required by Federal Food, Drug and Cosmetic Act in 1938, but not until the Drug Amendments of 1962 did firms also have to show a drug’s effectiveness before marketing. Before any drug gets on the market today, FDA decides—as quickly as a thorough evaluation allows—whether the studies submitted by the drug’s sponsor(usually the manufacturer) show it to be safe and effective for its intend use.1.embrace [im'breis] vt. 包括; 包含；接受；信奉, 皈依vt. & vi.拥抱n.拥抱, 怀抱2.cosmetic [k?z'metik]n.化妆品adj.化妆用的; 美容的；装点门面的Federal Food, Drug and Cosmetic Act联邦食品、药品和化妆法案3.Drug Amendments [?'mendm?nts] 药品法修正案4.thorough ['θ?r?u] adj.彻底的；十足的；考虑周到的5.sponsor ['sp?ns?] vt.赞助, 发起, 主办n. 申办者事实上，直到25年前美国药品管理法才刚刚引入“风险-益处评估”的概念。
药学英语第五版原文翻译.doc
Although there have been many important physiological invest
human volunteers, the need for precise control over the experimental 通过实验观察得知。尽管我们对志愿者进
To study how an animal works it is first necessary to know how it is 物生理学。
built. A full appreciation of the physiology of an organism must therefore
要研究一种动物如何活动，首先需要
to divide the subject into various parts such as bacterial physiology, plant 有的。鉴于此有必要将这门学科分成不同
physiology, and animal physiology.
部分研究， 如细菌生理学、 植物生理学和动
and dogs. When it is clear that a specific physiological process has a 识还是源于对其它动物如青蛙， 兔子，猫和
common basis in a wide variety of animal species, it is reasonable to 狗等的研究。当我们明确大多数动物物种
physiology and endowed us with a solid foundation for the effective 种方法， 我们获得了大量的知识， 从而让我
treatment of many diseases.
药学英语Unit4 Text A注释及译文
Unit FourText A The Scope of PharmacologyIn its entirety, pharmacology embraces the knowledge of the history, source, physical and chemical properties, compounding, biochemical and physiological effects, mechanisms of action, absorption, distribution, biotransformation and excretion, and therapeutic and other uses of drugs. Since a drug is broadly defined as any chemical agent that affects living processes, the subject of pharmacology is obviously quite extensive.1.entirety [en'taɪərɪti:] n.整体,全面in its entirety作为一个整体2. compounding ['kɑmpaundiŋ] n.配料；组合；复合3. Mechanism ['mekənizəm] n. 机械装置；构造, 机制；办法, 技巧, 途径4. absorption [əb'sɔrpʃən] n.吸收；吸收过程；吸收作用；专注，专心致志；合并；同化5. distribution [,distri'bju:ʃən] n.分发, 分配；散布, 分布6. biotransformation [,baiəu,trænsfə'meiʃən] n.生物转化metabolism [mɪ'tæbə,lɪzəm] n.新陈代谢7. excretion [eks'kri:ʃən] n.(动植物的)排泄,排泄物8. therapeutic [,θerə'pju:tik] adj.治疗(学)的;疗法的；对身心健康有益的9. living ['liviŋ]adj.活(着)的；现存的, 在使用中的；逼真的, 生动的n.生计, 生存之道；生活方式整体而言，药理学包括药学发展的历史，药物的来源、理化性质、配伍，药物对机体的生化过程和生理功能的影响，药物的作用机制，药物的吸收、分布、生物转化和排泄，药物的治疗作用和其他作用。
(完整版)药学英语第五版原文翻译
Introduction to PhysiologyIntroductionPhysiology is the study of the functions of living matter. It is concerned with how an organism performs its varied activities: how it feeds, how it moves, how it adapts to changing circumstances, how it spawns new generations. The subject is vast and embraces the whole of life. The success of physiology in explaining how organisms perform their daily tasks is based on the notion that they are intricate and exquisite machines whose operation is governed by the laws of physics and chemistry.Although some processes are similar across the whole spectrum of biology—the replication of the genetic code for or example—many are specific to particular groups of organisms. For this reason it is necessary to divide the subject into various parts such as bacterial physiology, plant physiology, and animal physiology.To study how an animal works it is first necessary to know how it is built. A full appreciation of the physiology of an organism must therefore be based on a sound knowledge of its anatomy. Experiments can then be carried out to establish how particular parts perform their functions. Although there have been many important physiological investigations on human volunteers, the need for precise control over the experimental conditions has meant that much of our present physiological knowledge has been derived from studies on other animals such as frogs, rabbits, cats, and dogs. When it is clear that a specific physiological process has a common basis in a wide variety of animal species, it is reasonable to assume that the same principles will apply to humans. The knowledge gained from this approach has given us a great insight into human physiology and endowed us with a solid foundation for the effective treatment of many diseases.The building blocks of the body are the cells, which are grouped together to form tissues. The principal types of tissue are epithelial, connective, nervous, and muscular, each with its own characteristics. Many connective tissues have relatively few cells but have an extensive extracellular matrix. In contrast, smooth muscle consists of densely packed layers of muscle cells linked together via specific cell junctions. Organs such as the brain, the heart, the lungs, the intestines, and the liver are formed by the aggregation of different kinds of tissues. The organs are themselves parts of distinct physiological systems. The heart and blood vessels form the cardiovascular system; the lungs, trachea, and bronchi together with the chest wall and diaphragm form the respiratory system; the skeleton and skeletal muscles form the musculoskeletal system; the brain, spinal cord, autonomic nerves and ganglia, and peripheral somatic nerves form the nervous system, and so on.Cells differ widely in form and function but they all have certain common characteristics. Firstly, they are bounded by a limiting membrane, the plasma membrane. Secondly, they have the ability to break down large molecules to smaller ones to liberate energy for their activities.生理学简介介绍生理学是研究生物体功能的科学。
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药学英语Unit 1Inflammatory reaction induced by local ischemic injury is one of the important pathophysiological characteristics after ischemic stroke, so anti-inflammatory therapy may be an effective strategy for acute ischemic stroke. Enlimomab, an anti-ICAM-1 murine monoclonal antibody, can inhibit the recruitment and activity of polymorphonuclear leukocytes, reduce their adhesion and decrease cerebral infarct size in experimental stroke models. However, a much larger efficacy trial including 625 acute ischemic stroke patients has shown that enlimomab was ineffective on ischemic stroke patients even with a worsening outcome. The therapeutic time window of rt-PA is within 3 hours of ischemic onset. Administration of the drug after more than 3 hours of ischemic onset has no significant therapeutic implications and may even end up with an increased hemorrhagic risk. A study using the animal ischemic model indicated that combination of anti-inflammatory therapy and rt-PA could significantly and might as well extend the therapeutic time window of thrombolysis.局部脑缺血损伤引起的炎症反应是缺血性脑卒中发生后的重要病理生理特征，因此，抗炎治疗策略可能是治疗急性缺血性脑卒中的一种有效方法。
恩莫单抗是一种抗细胞间黏附分子-1的单克隆抗体，在实验性脑缺血模型上，能抑制多形核白细胞的募集和活化，减少其黏附，降低脑梗死范围。
然而，一项由625例急性缺血性脑卒中患者参加的大规模的有效性临床试验却显示，使用恩莫单抗治疗，对缺血性脑卒中患者无效，且可能使病情恶化。
rt – PA的治疗时间窗为脑缺血发病后3小时，超过3小时后用药则无明显治疗意义，并有可能增加出血性风险。
一项在动物脑卒中模型上的研究表明，将抗炎治疗与rt-PA治疗联合应用，能显著减少梗死范围，改善神经功能结果，而不增加出血性风险，还可能延长溶栓治疗的时间窗。
Unit 2Drug discovery is the identification of novel active compounds, which are typically found by screening many compounds (from compound library) for the desired biological properties. In general, drug discovery is a very time-consuming and expensive process. Estimates of the average time required to bring a drug to the market range from12-15 years at an average cost of about $800 million. For approximately every 10000 compounds that are evaluated in animal studies, 10 will make it to human clinical trials in order to get 1 compound on the market. This is why the cost to purchase a drug is so high.The search of lead compound and the structural modification of lead compound for pharmacological optimization are the important two steps for new drug research in medicinal chemistry.课文翻译：药物发现通常是从许多化合物中（从化合物库中）鉴定和筛选具有所需药理作用的新型活性化合物的过程。
一般而言，药物发现是一个非常耗时和昂贵的过程。
一种新药的研发和投放市场平均需要约12-15年的时间，其成本约8亿美元。
一般用动物实验来评价药理活性的每10000个化合物中，只有10个才能进入人体临床试验，而最后1个能被开发成药物而投放市场。
这就是为什么新药研发的成本如此之高。
以新型先导化合物的发现及先先导化合物的结构优化来改善药理活性是药物化学中新药研究的两步重要过程。
Unit 3With suspensions of amine salts, both solubility and rate of degradation are functions of pH. The pH of optimum stability will be that at which the product of solubility and rate is a minimum. In addition, anything which reduces the solubility of the salt will aid stability, e.g., addition of a soluble salt of the amine, salting out, etc. From the reports available to date ampicillin might be most stable penicillin available, in both acid and neutral solution. Ampicillin, at pH 7.0 and room temperature, maintains 80% of its activity for I week. Whereas one would suspect that the other newer penicillins would show a dependence of rate of loss of activity on pH similar to that of penicillin G, one might also speculate that ampicillin might be different because of its zwitterionic character at almost neutral Ph.对于铵盐的悬浮液，其溶解性和降解率都受到pH值功能的调节。
最稳定的pH值可以使产品的溶解性和降解率达到最低。
此外，任何降低盐溶解性的物质都将有助于其保持稳定性，例如，加入胺的可溶性盐，盐析等。
据报道可以得知氨苄青霉素可能是现存在中性及酸性条件下最稳定的青霉素。
氨苄青霉素在中性溶液以及室温条件下保存1星期其活性维持在80%左右。
然而有人发现其他的一些新型青霉素和青霉素G一样，活性依赖于pH值的高低，也有人推断氨苄青霉素可能不一样，因为在近乎中性的条件下它是两性离子。
Unit 4Comparison of HPLC to gas chromatography (GC) is instructive in pointing out similarities and differences. In both methods, the separation of components in a mixture is achieved in flowing stream. The mechanisms of retention differ greatly but parallels can be drawn in many cases. In both HPLC and GC, components which preferentially interact with the stationary phase will be retained longer. In GC, the mobile phase, or carrier gas, has little effect on the separations (other than the flow rate). Consequently, separations are achieved by manipulation of the stationary phase or the sample (e.g. derivatization to improve volatility). A large number of stationary phases have been developed and are commercially available. In essence, GC can be characterized as having one mobilephase and many stationary phases. On the other hand, HPLC has developed with relatively few stationary phases. It is the mobile phase that gives great diversity to HPLC. Binary, ternary, and occasionally quaternary mobile phase compositions are used. Buffers are added to control PH, and ion-pairing reagents are added to modify the retention. In GC, temperature programming, and even flow programming, can be used to increase the separative power of the system. In HPLC, the mobile phase composition is changed in a programmed fashion in order to achieve comparable effects.高效液相色谱法与气象色谱法（GC）两者既有相似点又有区别。