BASF 杀菌剂 Biocide_Training_Asia_2012_FT

Training Biocides Formulation Technologies
January 16th 2011, Sametime Meeting
Frank Bienewald, Jürgen Wiethan, EMD/DF, Grenzach, Germany
January 16th 2012
1


Agenda
Biocides – General Introduction Overview BASF Biocide Product Portfolio Main FT Applications and more Technical Details of Products
January 16th 2012
CONFIDENTIAL / INTERN
2


What is a Biocide ?
There are various different legal and scientific definitions There is potential for overlap and for grey areas
Example Definition - from 98/8/EC (EU Biocidal Products Directive) Biocidal products: Can be active substances or preparations Can contain one or more active substances Are intended to destroy, deter, render harmless, prevent the action of, or otherwise exert a controlling effect on any harmful organism Act by chemical or biological means
January 16th 2012
CONFIDENTIAL / INTERN
3


Why do we use Biocides ?
• Visual growth • Odour generation • Colour changes • Viscosity changes • Corrosion • Leads to economic loss • Possible health effects - pathogens
January 16th 2012
CONFIDENTIAL / INTERN
4


Biocide Market Trends
Awareness of health / hygiene (avian influenza, MRSA, SARS….) Water-based products increasing (paints, adhesives etc.) Water re-use (e.g. paper production, industrial water treatment) Negative opinions of certain biocides (e.g. parabens, formaldehyde, triclosan). Often not scientifically based. Increasing regulation leading to reduced number of AIs Labelling restrictions on common AIs
January 16th 2012
CONFIDENTIAL / INTERN
5


Biocides – Trends, Needs, Claims Biosecurity
Spa baths Precautions against SARS MRSA – hospital “superbug” Legionella bacteria
Decontamination of anthrax infected building
January 16th 2012
E.coli
CONFIDENTIAL / INTERN
6


Biocides – Trends, Needs, Claims Household Hygiene
Bathroom and toilet cleaning
Odour control
Built in hygienic surfaces
Mould prevention
January 16th 2012
CONFIDENTIAL / INTERN
7


Biocides – Trends, Needs, Claims Household Articles
January 16th 2012
CONFIDENTIAL / INTERN
8


Biocides – Trends, Needs, Claims Maintaining Efficiency in Industry
Marine fouling
Membrane fouling
Biomass in a deaerator (oil production)
Microbially induced corrosion
January 16th 2012
Slime in paper production
CONFIDENTIAL / INTERN
9


Product Overview
January 16th 2012
INTERN
10


Overview BASF Biocide Product Portfolio
Active Substance Application Area
Human Hygiene Private and Public Health Area Medical, Man, Industry Swimming Pool Air-Conditioning Chemical Toilets/Waster Others Veterinary Hygiene Food and Feed Hygiene In-can Preservatives Metal Working Fluids Film Preservatives Plastic & Textile Materials Masonry Construction Materials Liquid Cooling Systems Slimicides (Industrial Processes) Paper Pulp Mineral Oil Marine antifouling January 16th 2012
TCS = Triclosan (Irgasan DP300), HP = Tinosan HP100
BN
GA
DZ
HT
GL
CD
PE
X
FM
TCS
X
HP
Irgaguard
Irgarol
X
X X
X X
X X
X X
X X
X
X X X
X X X X X X X X X X X X X X X X X X X X X X X X
X
X
X X X X
X X X X X X X X X
CONFIDENTIAL / INTERN
11


Products I
Protectol BN Effective bactericide Preservation use
NO2 HO Br OH
Protectol PE Cosmetic preservation In-can preservation (incl. household products) and disinfection uses Metalworking Fluids (also solvent properties)
O OH
Protectol GA 50 Fast acting biocide Disinfection and water preservation uses
H O
January 16th 2012
Protectol GL Disinfection and water preservation uses Useful co-biocide (e.g. combination with GA)
O H
CONFIDENTIAL / INTERN
H O
O H
12


Products II
Protectol FM Formaldehyde-free Broad spectrum activity Biodegradable with attractive environmental and safety profile Disinfection uses
Aseptrol Products based on delivery of chlorine dioxide (ClO2), strong biocide at very low concentrations Tablet technology for uses in water solutions (disinfection) Sachet technology for release of ClO2 gas to the atmosphere (odour-control and disinfection) Fits best with small to medium sized applications
H O
OH
Cl O
January 16th 2012
O
13
CONFIDENTIAL / INTERN


Products III
Irgasan DP300 / Irgacare MP Broad-spectrum biocide with longlasting activity PC, oral care uses, hand disinfectants
Tinosan HP100 Broad-spectrum biocide with longlasting activity on treated surfaces Uses in laundry care, surface cleaners and disinfectants
OH O Cl Cl Cl
Cl O Cl
OH
January 16th 2012
CONFIDENTIAL / INTERN
14


Products IV
Protectol DZ Effective biocide Readily biodegradable
Protectol HT Formaldehyde releaser Alkaline pH stable
S H3C N N
S CH3
HO
N N
N
OH
OH
January 16th 2012
CONFIDENTIAL / INTERN
15


Products V
Irgarol 1051 Algicide Uses in marine antifouling
H N N N N NH S
Irgaguard B range Silver zeolites and silver glass Uses in plastics, textile fibres
Silver-Zinc Zeolite Silver-Zinc Glass
January 16th 2012
CONFIDENTIAL / INTERN
16


“Biocide Map” - FT Applications
Active Substance Application Area In-can Preservatives Metal Working Fluids Plastic & Textile Materials Slimicides (Industrial Processes) Paper Pulp Mineral Oil X X X X X X X X X X BN X GA X DZ X HT X X GL PE X X X FM X Irgaguard
January 16th 2012
CONFIDENTIAL / INTERN
17


Applications
January 16th 2012
INTERN
18


Industrial Preservation
January 16th 2012
INTERN
19


Preservation Applications Products Requiring Preservation
Products most at risk: – Have a high water content – Are formulated with a final pH of 2-10 – Have a high organic content (natural or synthetic) – Are used or stored in environments with a high ambient temperature Industrial Products • Water based paints and polymer dispersions • Adhesives, sealants, fillers, lithographic solutions and inks • Pigment and mineral slurries Cosmetic Product Preservation • Skin creams, lotions, shampoos, conditioners, shower gels and wet tissues Household Products • Dishwashing liquids, cleaners and liquid polishes
January 16th 2012
CONFIDENTIAL / INTERN
20


Arch (now Lonza)
Protectol BN
•Good combination active ingredient with CIT/MIT, BIT (compensating weaknesses of BN against fungi)
•Use in blends to remove R43 labelling requirements for CIT
•Effective against Pseudomonas strains (problem for BIT)
•Regulatory approvals
Protectol GA
•May be used for quick “knock-down”e.g. for mineral slurries
Protectol HT
•Formaldehyde releaser with good high pH stability
•Good combination partner for BIT
•Regulatory approvals
Protectol DZ
•Broad spectrum control. Use in e.g. starch based systems and paper additives
Specialist formulators of preservatives for industry:
•Clariant
•Schülke & Mayr
•Thor
•ISP
•Arch (now Lonza)
•Dow
Single actives are frequently combined because of their unique advantages A formulation(blend) can be used to obtain optimal antimicrobial protection e.g. broad spectrum activity, long term stability, low tolerance
BIT -good fungicide, but gaps in antibacterial activity
Bronopol -excellent bactericide, but poor fungicide
BIT/Bronopol formulation -excellent broad spectrum activity
Metalworking Fluids
80% Mineral Oil
8% Emulsifiers
8% Corrosion Inhibitors 3% Biocide/Fungicide 1% Antifoam
Arch (now Lonza) Arch (now Lonza)
Arch (now Lonza)
Broad spectrum antimicrobial performance
Widely accepted (in Europe)
Cost effective alternative to formaldehyde release technologies
Compatible with other active ingredients and raw materials
Easy to use, readily incorporated into a variety of formulation types
Excellent solvent properties and coalescing abilities
Biodegradable
Non-irritating and non-sensitising at in-use level
Use in concentrate at typically 10%
–Concentration typically around 1% in final fluid
–Use in conjunction with fungicide and optionally further bactericide
Oil & Gas Exploration
Stimulate production of oil from reservoir Prevent contamination of oil reservoir
S formation (oil souring)
Packing fluid
Oil & Gas Production Products and Competitors
Application Injection and Production Product Glutaraldehyde Glutaraldehyde THPS Quats Muds and Fluids Preservation Bronopol Bronopol DBNPA Glutaraldehyde Glutaraldehyde Various formaldehyde releasers Protectol BN Bioban Dow Antimicrobial Protectol GA 50 Ucarcide Brand Protectol GA 50 Ucarcide Tolcide Supplier BASF Dow Rhodia Akzo, Rhodia, Lonza BASF Dow Dow BASF Dow
January 16th 2012
CONFIDENTIAL / INTERN
31


Oil & Gas Production BASF Products
Protectol GA50 (some Protectol GA24) • Fast acting, broad spectrum biocide • Disinfects and preserves • Cost effective vs. THPS • Safe to handle with appropriate procedures • Good environmental profile (e.g. biodegradable) Protectol BN • Long lasting preservative bactericide • Cost effective vs. DBNPA • Good tox profile • Easy to handle
January 16th 2012
CONFIDENTIAL / INTERN
32


Pulp & Paper
January 16th 2012
INTERN
33


Pulp and Paper Biocide use in Pulp and Paper
Application Areas for Paper Industry Biocides - Slimicides – prevention of slime build-up in process - Mineral Slurries – preservation of slurries
January 16th 2012
CONFIDENTIAL / INTERN
34


Pulp and Paper No/Wrong Biocide use in Pulp and Paper…
Loss of production Reduction in quality Microbiological corrosion Loss of additives Gas production Off spec and rejected Paper
January 16th 2012
Unscheduled breakage Slime spots, holes, odour Damage to metals, stainless steel Reduce additive effect, plug lines H2, H2S or methane creating the potential for explosions Cost of re-working & loss of product / customers
CONFIDENTIAL / INTERN
35


Pulp and Paper Papermaking Process
Biocides
Biocides Biocides
January 16th 2012
CONFIDENTIAL / INTERN
36


Pulp and Paper Products and Competitors
Application Slimicides Product Glutaraldehyde Glutaraldehyde Isothiazolinones Isothiazolinones DBNPA Bronopol Dazomet MBT Mineral Slurry Preservation Isothiazolinones Isothiazolinone Bronopol Various formaldehyde releasers Brand Protectol GA 50 Piror Kathon Acticide Dowicil Protectol BN Protectol DZ Busan Kathon Proxel Protectol BN Preventol Bodoxin Supplier BASF Dow Dow Thor Dow BASF BASF Buckman Dow Arch (now Lonza) BASF Lanxess Bode
January 16th 2012
CONFIDENTIAL / INTERN
37


Pulp and Paper BASF Products
Paper slimicide use is a core application for BN and GA
Protectol BN / Myacide AS/S • Highly effective against Pseudomonas types (BIT shows resistance) • Good efficacy against slime forming bacteria (vs. competitive products) • Cost effectiveness vs. competitor products (DBNPA, Isothiazolinone etc.) • Very effective in combination with isothiazolinones • Regulatory approvals Protectol GA50 / Myacide GA • “Quick kill” biocide • Broad efficacy spectrum • Cost effectiveness / efficacy vs. competitor products (THPS, Peracetic acid) • Regulatory approvals
January 16th 2012
CONFIDENTIAL / INTERN
38


Pulp and Paper BASF Products
Protectol DZ The most important benefits are its rapid speed of kill and broad spectrum of activity. Paper Mill Process Water Protectol DZ is very active at low doses within the paper industry. For use as a slimicide it should be dosed at 50g to 150g per tonne of finished paper. Bulk Pulp As a preservative for bulk pulp and paper mill auxilliaries (e.g. mineral slurries) 100500ppm Protectol DZ is recommended.
January 16th 2012
CONFIDENTIAL / INTERN
39


Plastic and Textile Materials
January 16th 2012
INTERN
40


Synthetic (plastic) surfaces are often an ideal support for microbial growth supported by appropriate environmental
conditions (humidity, temperature, nutrients)
Microbial growth can lead to
●hygiene problems (microbial contaminations →infections)
●staining, discoloration, odor
●material destruction, loss of physical properties
Antimicrobial technologies mainly based on built-in additives with a more or less adjustable release behaviour (antibacterial ones are often silver-based as for example IRGAGUARD®from
BASF)
IRGAGUARD®-
Antimicrobial solutions based on inorganic Silver-Technology
-Training Biocides / Formulation Technologies -
Jürgen Wiethan, E-EMD/DF, January2012
Appearance of Irgaguard®
White to off-white powder Masterbatch
Silver-Zinc Zeolite Silver-Zinc Glass
B 5000silver-zinc zeolite
B 512020% masterbatch of B 5000 in LDPE
B 6000silver-glass / zinc-zeolite
B 7000silver-zinc-glass
B 762020% masterbatch of B 7000 in PET
CGX 51-505silver-glass#
EB 50-98020% masterbatch of CGX 51-505 in PET# # preliminary product status (not listed yet)
* continuously enhanced and expanded
Multiple kill mechanism
Inactivation of enzymes
groups)
Direct binding to DNS (inhibition of replication)
Damage of cell structure and cell membrane
low risk of microbial resistance
Efficacy: Bacteria
Gram positive Bact.
Suitability for transparent applications
no
yes
yes
no
EFSA
SML
(0,05mg/kg
)
SML
(0,05mg/kg
)
* PT 2 ~ disinfection, PT 7 ~ film protection, PT 9 ~ fibers & polymers (BPD-Evaluation process still under examination)
Recommendation of use as active substance*
•0.3% –1,5% IRGAGUARD B 5000/7000
•0.2% –1,2% IRGAGUARD B 6000
•0.3% –1,5% CGX 51-505
Recommendation of use as masterbatch*
• 1.5% –7.5% IRGAGUARD B 5120 (20% MB of B5000 in LDPE)
• 1.5% –7.5% IRGAGUARD B 7620 (20% MB of B7000 in PET)
• 1.5% –7.5% EB 50-980(20% MB of CGX 51-505 in PET)
* depending on polymer type and additives, target application, target organisms etc.。