我国兽用基因工程疫苗研发现状与策略_智海东

动物医学进展,2011,32(6):174-178

Progress in Veterinary Medicine

我国兽用基因工程疫苗研发现状与策略

智海东1,2,王云峰1,陈洪岩1,2

(1.中国农业科学院哈尔滨兽医研究所　兽医生物技术国家重点实验室,黑龙江哈尔滨150001;

2.哈尔滨维科生物技术开发公司,黑龙江哈尔滨150069)

摘　要:基因工程疫苗的研究发展日新月异,已从理论研究进入到实际生产应用,成为生物制品产业发展的一种趋势。近年来我国在兽用基因工程疫苗研发领域取得了很大进展,一些亚单位、活载体、基因缺失以及采用反向遗传操作技术制备的禽流感疫苗等兽用基因工程疫苗已经商品化,论文对我国兽用基因工程疫苗研发现状进行综述并提出相应发展策略。

关键词:兽用基因工程疫苗;亚单位疫苗;基因缺失疫苗;活载体疫苗;反向遗传操作技术

中图分类号:S852.5文献标识码:B文章编号:1007-5038(2011)06-0174-04

兽用生物制品对我国畜牧业的发展起着重要的作用,动物疫苗的使用极大程度地保证了畜牧业的健康发展[1]。但随着集约化养殖规模的扩大和新疫病的不断出现,现有的常规疫苗已经不能满足畜牧业发展的需要,与此同时一些以基因工程手段研制的基因工程疫苗逐渐进入市场应用领域。近年来我

收稿日期:2011-03-29

作者简介:智海东(1972-),男,博士,副研究员,从事兽用生物制品研发工作。

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Clinical Strategies for T Cell Immune Reconstitution

YIN Fan,LI Jiang,LI Yu-gu

(College o f Veterinary Medicine,Sou th China Ag ricu lture University,Guang z hou,Guang dong,510642,China)

A bstract:T cell deficiencies have been associated w ith thy mic atro phy and often occur in infections,autoim-m une diseases,chem o/radio therapy as w ell as aging of the imm une sy stem.Currently,several strateg ies fo r reversal of thy mic atro phy and T cell reco nstitutio n a re being tested in the clinic,such as,using inter-leukin-7,interleukin-15,interleukin-12,ke ratino cy te grow th facto r,grow th ho rmone,ghrelin,Flt3L, sex ho rmone inhibitors and T-cell precurso rs etc.In this paper,the effects of these facto rs on T cell im mune reconstitution w ere reviewed.

Key words:T cell;IL-7;KGF;G H;sex ho rm one