医学免疫学-细胞因子精品PPT教学课件
合集下载
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
2020/12/6(IL-1 + IL-4)
拮抗作用
IFN-
↓+
LAK细胞增殖 ↑ˉ
TGF-
双向性 抗肿瘤
↑适量 TNF ↓过量 BSS
(细菌性脓毒 血症休克)
6
Ⅱ.Classification of CKs
1.Interleukin (IL)
白细胞介素是一组由由淋巴细胞或其他单个 核細胞产生的介导白细胞间相互作用的细胞因子, 也参与其他细胞的相互作用
第一课件网网站
2020/12/6
10
5.Growth factor (GF)
---一类能介导不同类型细胞生长和分化的CKs
A.EGF,NGF,VEGF,PDGF and
TGF-
• proliferation of
lymphocytes
immune
• maturation of CTL
suppress
• activation of M • cytotoxicity of CTL
B.IL-2 and TNF
and NK cell
2020/12/6
11
6. Chemokine
---一类对不同靶细胞具有趋化效应的CK家族
CXC/ chemokine IL-8 CC/ chemokine
MCP (单核细胞趋化蛋白)
一类能引起肿瘤组织出血坏死的细胞 因子,故称为肿瘤坏死因子
A.TNF- and TNF-
(内分泌,恶液质素)
(lymphotoxin, LT)
B. Biologic effects (homological trimer)
Anti-tumor(直接杀死肿瘤细胞)
Take part in inflammation and
endotoxic shock (双向效应)
2020/12R/6 egulate IR
9
4. Colony stimulating factor (CSF)
----是一类可选择性刺激造血干细胞增殖 分化为某一谱系细胞集落的细胞因子
kinds :G-CSF,M-CSF,GM-CSF, multiCSF (IL-3 ), SCF, EPO,TPO and so on.
Synergy & antagonism
• synergy
IL1 and IL-4
2020•/12a/6ntagonism IFN- and TGF-
5
多效性 LAK 增殖
B
分化ຫໍສະໝຸດ Baidu
IFN-
Th2 分泌活性
NK 杀伤活性
重叠性 IL-2,4,7,9,12
↓ T细胞增殖
协同作用
IL-1 IL-4 ↓↓ B 细胞增殖
B.Secretory feature
C.CKs network
2020/12/6
2
A.Biological properties
Low molecular-weight protein or glycoprotein (MW 15 ~30KD) Monomer, dimer or trimer Rapid reactivity and high efficiency (CK binding to CKR) Nonspecific and non-MHC restriction
2020/12/6
3
B.Secretory feature
Transient and self-restraint Autocrine and paracrine Endocrine (also called immunohormone)
2020/12/6
4
C. CKs networks
Multicellular sources
•IL-12 ,TNF and IFN- →M
A.direct effects
•IFN- / , IL-12,IL-15 (anti-virus)
•IL-1,6,8 and TNF (anti-bacteria)
•TNF,IFN (anti-tumor)
B.by means of activating effector cells
•IL-2,12 and IFN-→ NK cell
C/ chemokineMIP (巨噬细胞炎症蛋白)
lymphotactin (淋巴细胞趋化蛋白)
新近报道还有CX3C/ chemokine
2020/12/6
12
Ⅲ. Biological Activities of CytoKines
1.Anti-infection and anti-tumor
Chapter 5
➢ Introduction of Cytokines ➢ Classification of CKs ➢ Biological Activities of CKs ➢ Cytokine Receptor (CKR) ➢ Clinical Application of CKs
2020/12/6
具有干扰病毒复制能力的细胞因子, 故称干扰素
A. IFN-/ (typeⅠ) and IFN- (typeⅡ )
B.Biologic effects
antivirus
anti-tumor
immunoregulation
2020/12/6
8
3. Tumor necrosis factor (TNF)
• T→IL2-6,9,10,13
• T,Mo/M→IL-1,6,10,GM-CSF
Complexity of biological effects
• pleiotropy (多效性)
IFN-
• overlapping（重叠性） IL-2,4,7,9,12
• two-way effects (双向性) TNF
A.IL-1 to IL-22
B.Biologic effects
activate immune cells
take part in immunoregulation,
hematopoiesis and inflammation
2020/12/6reaction
7
2.Interferon (IFN)
第一课件网网站
1
Ⅰ.Introduction of cytokine (CK)
1.Conception of CK
---由免疫细胞及非免疫细胞 经刺激 而合成、分泌的一类具有多 种生物 活性的小分子蛋白质
2.Common properties of CKs
A.Biological properties
拮抗作用
IFN-
↓+
LAK细胞增殖 ↑ˉ
TGF-
双向性 抗肿瘤
↑适量 TNF ↓过量 BSS
(细菌性脓毒 血症休克)
6
Ⅱ.Classification of CKs
1.Interleukin (IL)
白细胞介素是一组由由淋巴细胞或其他单个 核細胞产生的介导白细胞间相互作用的细胞因子, 也参与其他细胞的相互作用
第一课件网网站
2020/12/6
10
5.Growth factor (GF)
---一类能介导不同类型细胞生长和分化的CKs
A.EGF,NGF,VEGF,PDGF and
TGF-
• proliferation of
lymphocytes
immune
• maturation of CTL
suppress
• activation of M • cytotoxicity of CTL
B.IL-2 and TNF
and NK cell
2020/12/6
11
6. Chemokine
---一类对不同靶细胞具有趋化效应的CK家族
CXC/ chemokine IL-8 CC/ chemokine
MCP (单核细胞趋化蛋白)
一类能引起肿瘤组织出血坏死的细胞 因子,故称为肿瘤坏死因子
A.TNF- and TNF-
(内分泌,恶液质素)
(lymphotoxin, LT)
B. Biologic effects (homological trimer)
Anti-tumor(直接杀死肿瘤细胞)
Take part in inflammation and
endotoxic shock (双向效应)
2020/12R/6 egulate IR
9
4. Colony stimulating factor (CSF)
----是一类可选择性刺激造血干细胞增殖 分化为某一谱系细胞集落的细胞因子
kinds :G-CSF,M-CSF,GM-CSF, multiCSF (IL-3 ), SCF, EPO,TPO and so on.
Synergy & antagonism
• synergy
IL1 and IL-4
2020•/12a/6ntagonism IFN- and TGF-
5
多效性 LAK 增殖
B
分化ຫໍສະໝຸດ Baidu
IFN-
Th2 分泌活性
NK 杀伤活性
重叠性 IL-2,4,7,9,12
↓ T细胞增殖
协同作用
IL-1 IL-4 ↓↓ B 细胞增殖
B.Secretory feature
C.CKs network
2020/12/6
2
A.Biological properties
Low molecular-weight protein or glycoprotein (MW 15 ~30KD) Monomer, dimer or trimer Rapid reactivity and high efficiency (CK binding to CKR) Nonspecific and non-MHC restriction
2020/12/6
3
B.Secretory feature
Transient and self-restraint Autocrine and paracrine Endocrine (also called immunohormone)
2020/12/6
4
C. CKs networks
Multicellular sources
•IL-12 ,TNF and IFN- →M
A.direct effects
•IFN- / , IL-12,IL-15 (anti-virus)
•IL-1,6,8 and TNF (anti-bacteria)
•TNF,IFN (anti-tumor)
B.by means of activating effector cells
•IL-2,12 and IFN-→ NK cell
C/ chemokineMIP (巨噬细胞炎症蛋白)
lymphotactin (淋巴细胞趋化蛋白)
新近报道还有CX3C/ chemokine
2020/12/6
12
Ⅲ. Biological Activities of CytoKines
1.Anti-infection and anti-tumor
Chapter 5
➢ Introduction of Cytokines ➢ Classification of CKs ➢ Biological Activities of CKs ➢ Cytokine Receptor (CKR) ➢ Clinical Application of CKs
2020/12/6
具有干扰病毒复制能力的细胞因子, 故称干扰素
A. IFN-/ (typeⅠ) and IFN- (typeⅡ )
B.Biologic effects
antivirus
anti-tumor
immunoregulation
2020/12/6
8
3. Tumor necrosis factor (TNF)
• T→IL2-6,9,10,13
• T,Mo/M→IL-1,6,10,GM-CSF
Complexity of biological effects
• pleiotropy (多效性)
IFN-
• overlapping（重叠性） IL-2,4,7,9,12
• two-way effects (双向性) TNF
A.IL-1 to IL-22
B.Biologic effects
activate immune cells
take part in immunoregulation,
hematopoiesis and inflammation
2020/12/6reaction
7
2.Interferon (IFN)
第一课件网网站
1
Ⅰ.Introduction of cytokine (CK)
1.Conception of CK
---由免疫细胞及非免疫细胞 经刺激 而合成、分泌的一类具有多 种生物 活性的小分子蛋白质
2.Common properties of CKs
A.Biological properties