The Efficacy of High-Intensity Focused Ultrasound (HIFU) in Advanced Pancreatic Cancer
药物替代疗法英语作文初中
In the realm of healthcare, the concept of alternative medicine has gained significant traction over the years. As a high school student with a keen interest in the sciences, I have been particularly intrigued by the idea of drug replacement therapies. This essay delves into my exploration of this fascinating field, highlighting the potential benefits and the challenges associated with it.Drug replacement therapies, or what some refer to as alternative medicine, are treatments that are used in place of conventional pharmaceutical drugs. This approach can include a wide range of practices, from herbal remedies and acupuncture to homeopathy and chiropractic care. My journey into understanding this field began with a personal health issue that traditional medicine seemed to struggle with.I suffered from chronic headaches that were not effectively managed by the prescribed medications. The side effects were bothersome, and the relief was only temporary. It was then that I started to consider alternative options. I began researching various drug replacement therapies, and my first encounter was with acupuncture. This ancient Chinese practice involves the insertion of thin needles into specific points on the body to alleviate pain and treat various conditions.My experience with acupuncture was both enlightening and transformative. The practitioner explained that the therapy works on the principle of balancing the bodys energy flow, known as Qi. The process was surprisingly calming, and after several sessions, I noticed a significant reduction in the frequency and intensity of my headaches. This personalsuccess story sparked a deeper curiosity about the efficacy of alternative therapies.However, its important to note that the effectiveness of drug replacement therapies can be a contentious issue. While some studies suggest that certain alternative treatments can be as effective as, or even more effective than, traditional medications, others argue that the evidence is anecdotal and lacks scientific rigor. For instance, herbal remedies, which have been used for centuries in various cultures, are often touted for their healing properties. Yet, the regulation and standardization of these remedies can be inconsistent, leading to concerns about their safety and efficacy.Moreover, the integration of drug replacement therapies into mainstream healthcare is not without its challenges. There can be a lack of understanding and acceptance among medical professionals, who may not be trained in these alternative methods. Additionally, insurance coverage for such treatments can be limited, making them less accessible for many patients.Despite these hurdles, I believe that the potential benefits of drug replacement therapies are worth exploring further. For one, they can offer a more holistic approach to healthcare, taking into account the patients overall wellbeing rather than just addressing a specific symptom. Furthermore, for individuals like myself who have not found relief through conventional treatments, these alternatives can provide a new avenue for healing.In conclusion, my foray into drug replacement therapies has been an eyeopening experience. It has shown me that there is more to healthcare than just the pills and potions offered by conventional medicine. While it is crucial to approach these alternatives with a critical and informed perspective, I am optimistic about the role they can play in complementing traditional treatments and improving overall health outcomes. As a high school student, I am excited to continue learning about this field and perhaps one day contribute to the ongoing dialogue about the future of healthcare.。
子宫腺肌病术前MR_T2WI信号特征与HIFU消融疗效密切相关：一项倾向性评分配对队列研究
子宫腺肌病是指子宫内膜组织（腺体和间质）浸润子宫肌层生长而产生的病变［1］；主要临床症状包括月经过多、严重痛经和不孕，会对患者身心健康造成严重影响［2,3］。
其中进行性加重的痛经是导致患者接受治疗的主要症状。
高强度聚焦超声（HIFU ）消融技术作为一种新型的无创治疗方法，其在子宫腺肌病的治疗中已获得广泛共识［4,5］。
MRI 因其良好的软组织分辨率，对子宫腺肌病的解剖学特征和组织病理学特征有较好显示［6］。
Preoperative MR T 2WI signal characteristics of adenomyosis are closely related with the outcome of high-intensity focused ultrasound ablation:a propensity score-matched cohort studyYU Jingwen 1,YANG Meijie 2,JIANG Li 1,XIAO Zhibo 3,LI Shuang 1,CHEN Jinyun 1,41College of Biomedical Engineering,State Key Laboratory of Ultrasound in Medicine and Engineering,2College of Medical Information,Chongqing Medical University,Chongqing 400016,China;3Department of Radiology,4Therapeutic Center of Ultrasound Ablation,First Affiliated Hospital of Chongqing Medical University,Chongqing 400042,China摘要：目的通过评估子宫腺肌病MR T 2WI 信号特征，探讨其对高强度聚焦超声（HIFU ）消融疗效的影响。
BTL高能激光治疗仪的操作步骤与疗效
4.Alayat M S M , Atya A M , Ali M M E , et al. Long-term effect of high-intensity laser therapy in the treatment of patients with chronic low back pain: a randomized blinded placebo-controlled trial[J]. Lasers in Medical Science, 2014, 29(3):1065-1073.
治疗作用：
1.BTL 半导体高能量激光技术基于低能量激光(LLLT) 的作用原理，结合生物刺激和光学机械 刺激，通过快速、高效的增加组织对 ATP 的运用能力，促进局部组织的血液循环, 缓解轻微 肌肉和关节疼痛、肌肉痉挛。 2.BTL 高能量激光高达 12000mW 的能量可穿透深层组织，达身体任一疼痛部位。 3.BTL 高能量激光治疗结合了生物 刺激和光学机械刺激，在促进组织愈合的同时提供强大 且非致瘾性的疼痛管理。激光，由于它的单色性和一致性可以精确调整和预先设定。 4.高功率的光具有极高的穿透力，可确保适当的剂量达到患区的组织深层。另外，特定波长 的光压波可刺激神经末端，阻断神经系统中的疼痛路径，使疼痛迅速缓解[6]。 5.对多种肌肉骨骼系统疾病具有更优的疗效表现，如肩峰撞击症[1]、足底筋膜炎[2]、腰椎间盘
高能激光治疗仪的操作步骤与疗效 操作步骤：
1.检查脚踏板、电源线的正确连接。 2.打开机器背后的电源总开关，等待开机。 3.输入密码。 4.进入参数设置界面，调整相应输出功率等参数。 5.治疗师佩戴护目镜，手持照射头，脚置于脚踏板上。 6.患者暴露治疗区域的皮肤。 7.照射头置于患者皮肤上方，踩下脚踏板开始治疗。 8.采用划圈或 S 形路线移动照射头，避免局部过热。 9.治疗结束后，放回照射头，并关闭电源总开关。
一次性电子输尿管软镜联合钬激光治疗上尿路结石的疗效
临床医学研究·58·一次性电子输尿管软镜联合钬激光治疗上尿路结石的疗效宋玉君1 陈 东1 武立新2【中图分类号】 R699 【文献标识码】 Ａ 【文章编号】 1671-8054（2021）01-0058-03【摘 要】 目的：探讨一次性电子输尿管软镜钬激光碎石术治疗上尿路结石的有效性和安全性。
方法：回顾性分析25例采用一次性电子输尿管软镜钬激光碎石术的临床资料。
20例患者术前预置内支架管2~4周，另5例患者未预置内支架管，进行一期手术。
术后记录软镜鞘置入成功率、手术时间、并发症发生率、结石即刻清除率、1个月后清除率、术后住院时间等指标。
结果：25例患者均顺利完成软镜碎石术，软镜鞘置入成功率100%。
手术时间35~120 min，平均（59.7±20.3）min；并发症：输尿管损伤2例，为黏膜损伤，Clavien-DindoⅠ级或Ⅱ级；术后发热2例；无尿源性脓毒血症发生。
结石即刻清除率48%、术后1个月清除率92%。
术后住院时间2~5天，平均（3.6±1.0）天。
结论：一次性电子输尿管软镜图像清晰,操控性好,免维护，避免交叉感染，联合钬激光碎石治疗上尿路结石疗效安全可靠，更适合在基层医院推广。
【关键词】 一次性输尿管软镜 钬激光 上尿路结石随着医疗技术设备的不断进步,输尿管软镜在过去十年发展迅速，其中一次性输尿管软镜在图像清晰度、镜体纤细化及操作通道改进方面取得了卓越的进步，成为软镜手术越来越重要的一部分[1]，也越来越受到临床医生的欢迎。
同时，一次性输尿管软镜避免了高昂的器械维护成本，免除了交叉感染的风险，在院内感染的预防及医疗经济学方面也具有显著优势。
本文回顾性分析我院通过一次性电子输尿管软镜治疗联合钬激光治疗25例上尿路结石患者的临床资料，探讨一次性电子输尿管软镜治疗上尿路结石的疗效及安全性。
1 资料与方法 1.1 一般资料 选择我院2020年3月-11月通过一次性电子输尿管软镜治疗联合钬激光治疗的25 例上尿路结石患者作为研究对象，年龄23~72岁，平均年龄（47.6±8.7）岁；其中男性18例，女性7例。
超声波的作用与功效的英语作文350字
全文分为作者个人简介和正文两个部分：作者个人简介：Hello everyone, I am an author dedicated to creating and sharing high-quality document templates. In this era of information overload, accurate and efficient communication has become especially important. I firmly believe that good communication can build bridges between people, playing an indispensable role in academia, career, and daily life. Therefore, I decided to invest my knowledge and skills into creating valuable documents to help people find inspiration and direction when needed.正文：超声波的作用与功效的英语作文350字全文共3篇示例，供读者参考篇1The Myriad Applications of Ultrasound WavesUltrasound, the acronym for ultrasonic sound waves, refers to acoustic vibrations with frequencies beyond the upper audible limit of human hearing, typically above 20,000 Hz. While thesehigh-pitched sound waves may be imperceptible to our ears, their diverse applications span numerous fields, making ultrasound a truly remarkable technological marvel.In the medical realm, ultrasound imaging, also known as sonography, has revolutionized diagnostic procedures. By utilizing high-frequency sound waves and their echoes, doctors can create detailed images of internal organs, muscles, and other structures within the body. This non-invasive technique is particularly invaluable in monitoring fetal development during pregnancy, enabling expectant mothers to catch glimpses of their unborn babies.However, ultrasound's utility extends far beyond medical diagnostics. It finds widespread use in industrial settings for tasks such as nondestructive testing (NDT) and material characterization. Engineers can employ ultrasonic waves to detect flaws, cracks, or defects in various materials, ensuring the structural integrity and safety of components without causing damage.Moreover, ultrasound has proven its efficacy in the field of cleaning and surface treatment. Ultrasonic cleaners harness the power of cavitation, a phenomenon where alternating high and low-pressure waves create millions of microscopic bubbles thatimplode, effectively removing contaminants from intricate and hard-to-reach areas. This process is particularly useful for cleaning delicate items like jewelry, optical components, and precision instruments.Interestingly, ultrasound has even found applications in the culinary world. Certain techniques, such as ultrasonic mixing and emulsification, can enhance the flavor and texture of various foods and beverages. Additionally, ultrasonic waves have been explored for potential use in food preservation, offering an alternative to traditional methods like thermal processing or chemical treatments.Despite its widespread adoption, research into ultrasound continues to unveil new and exciting possibilities. From novel medical therapies to advanced materials processing, the potential of these high-frequency sound waves remains boundless, and their impact on our lives is only set to grow in the years to come.篇2The Magic of Ultrasound: Unveiling Its Incredible Uses and EffectsAs a student fascinated by the marvels of science and technology, I have been captivated by the remarkable phenomenon of ultrasound. This invisible force, operating at frequencies beyond the human audible range, has proven to be a game-changer in various fields, revolutionizing the way we perceive and interact with the world around us.One of the most well-known applications of ultrasound is in the field of medical imaging. Ultrasound technology has become an indispensable tool in diagnostics, allowing healthcare professionals to peer into the depths of the human body without invasive procedures. Through the use of high-frequency sound waves, detailed images of internal organs, tissues, and even fetuses can be obtained, aiding in early detection and treatment of various conditions.However, the wonders of ultrasound extend far beyond medical imaging. Its versatility has found applications in diverse industries, ranging from manufacturing to environmental conservation. In manufacturing, ultrasonic welding and cleaning processes have streamlined production lines, ensuring precise and efficient operations. Meanwhile, in the realm of environmental protection, ultrasound has proven invaluable in monitoring and mitigating the impact of human activities onmarine life, enabling researchers to study the behavior and migration patterns of whales and other aquatic creatures without causing disturbance.But perhaps one of the most intriguing applications of ultrasound lies in its therapeutic potential. Emerging research has highlighted the promising use of focused ultrasound in treating various medical conditions, such as Parkinson's disease, essential tremor, and even certain types of cancer. By precisely targeting specific areas within the body, ultrasound waves can disrupt or destroy pathological tissues, offering a non-invasive alternative to traditional surgical interventions.As I delve deeper into the study of ultrasound, I am continually amazed by the boundless possibilities it presents. From its ability to detect microscopic flaws in materials to its potential in enhancing drug delivery systems, the applications of ultrasound seem limitless. As a student, I am inspired by the ongoing research and innovations in this field, and I eagerly anticipate the future breakthroughs that will undoubtedly shape our understanding and utilization of this incredible technology.In conclusion, ultrasound is a truly remarkable force that has revolutionized various aspects of our lives. Its versatility, precision, and non-invasive nature have made it anindispensable tool in a wide range of fields, from medicine to manufacturing and environmental conservation. As a student, I am in awe of the vast potential of ultrasound and the endless possibilities it holds for shaping a better future for humanity.篇3The Wondrous World of UltrasoundAs students, we've all had experiences with ultrasound technology, even if we didn't realize it at the time. That grainy, black and white image of a tiny being inside the womb – that's ultrasound at work! But ultrasound has so many more amazing applications beyond just peeking at unborn babies.At its core, ultrasound involves high-frequency sound waves that are inaudible to the human ear. These waves can travel through solid objects and fluids, and their echoes can be used to create detailed images. This imaging capability is what makes ultrasound so incredibly useful in the medical field.One of the most common uses of ultrasound is in diagnosing various conditions. Doctors can use ultrasound to examine organs like the heart, liver, and kidneys for any abnormalities or irregularities. It's also invaluable in monitoring the growth and development of fetuses during pregnancy.Unlike X-rays, ultrasound doesn't involve any harmful radiation, making it a safe and non-invasive diagnostic tool.But ultrasound isn't just about imaging – it can also be used for therapeutic purposes. High-intensity focused ultrasound (HIFU) is a cutting-edge technology that can be used to treat certain types of cancers and other conditions. The ultrasound waves are concentrated on a specific area, heating and destroying targeted tissues without harming surrounding healthy cells.Ultrasound even has applications beyond the medical realm. It's used in industries like manufacturing for tasks like flaw detection and quality control. Marine biologists use it to study the behavior and habitats of underwater creatures. And who could forget those fancy ultrasonic jewelry cleaners that use ultrasound waves to dislodge dirt and grime from intricate pieces?As technology continues to advance, the potential uses of ultrasound are only going to grow. From improving surgical precision to developing new cleaning methods, the possibilities are truly exciting. So the next time you see those grainy ultrasound images, remember – they're just the tip of the iceberg when it comes to this remarkable technology!。
别踩坑做了超声炮后遗症是永久的么做了超声炮脸肿多久后才消肿
别踩坑做了超声炮后遗症是永久的么做了超声炮脸肿多久后才消肿？--阅读 · --喜欢 · --评论超声炮可以能维持1~~2年左右的时间，具体还是要根据个人的皮肤状况来判断。
对于年龄比较小的，一般皮肤松弛速度是比较缓慢的，所以维时间较长，大概可以维持2年。
Ultrasonic gun can maintain 1~~2 years or so of time, specific or according to the individual skin condition to judge. For the younger age, the general skin relaxation speed is relatively slow, so the dimension time is longer, which can be maintained for about 2 years.【▲▲▲▲▲】别踩坑~做了超声炮后遗症是永久的么？做了超声炮脸肿多久后才消肿？如年龄较大者，皮肤松弛速度~~就会比较快~~~维持时间也会比较短，也是可以维持1年。
超声炮主要有两个头组合：刀头+炮头总共有5个理疗头，超声炮刀头就跟我常见到的传统超声刀的头没什么区别，只是能量肯定没有~~美版超声刀那么强。
超声炮大概在7天左右可以消除肿胀。
具体根据个人的体质状况不同，新陈代谢不同，所以消肿的时间也会存在一定的差异。
【▲▲▲▲▲】（Don't step on the pit ~ did the ultrasonic cannon sequela is permanent? How long after did ultrasonic cannon face is swollen just detumescence?别踩坑~做了超声炮后遗症是永久的么？做了超声炮脸肿多久后才消肿？）；lzj↓↓↓↓↓↓↓↓↓↓↓↓↓↓↓别踩坑~做了超声炮后遗症是永久的么？做了超声炮脸肿多久后才消肿？【■ ღ■ ღ■】正版超声炮本身并不会出现副作用，或者是后遗症。
高强度聚焦超声治疗子宫腺肌症疗效的临床研究
高强度聚焦超声治疗子宫腺肌症疗效的临床研究发表时间：2015-07-31T14:34:22.720Z 来源：《中国耳鼻咽喉头颈外科》2015年6月第6期供稿作者：伍玲[导读] 治疗后半年，显效160例(57.8%)，有效111例(40%)，共有271例患者子宫腺肌症病灶大小、临床症状得到不同程度改善。
伍玲四川省内江市第一人民医院 641000【摘要】目的：分析子宫腺肌症患者经过高强度聚焦超声消融治疗后临床症状改善情况，腺肌症病灶大小变化情况，探讨高强度聚焦超声治疗子宫腺肌症的疗效。
方法：选择子宫腺肌症患者277例。
给予高强度聚焦超声消融治疗。
治疗后半年进行随访，通过彩超检查观察腺肌症病灶大小变化情况，随访临床症状改善情况，评估治疗效果。
结果：1.277例患者治疗后均未发生严重不良反应。
治疗后总有效率97.8%。
2.治疗半年后随访，腺肌症病灶大小改善率和痛经症状改善率分别为97.8%和97.8%，月经增多改善率为100%。
（P<0.05，差异有统计学意义）。
关键词：聚焦超声治疗；子宫腺肌症；疗效High intensity focused ultrasound in the treatment of adenomyosis efficacyObjectives: Analysis of uterine adenomyosis patients after the improvement of clinical symptoms after HIFU ablation,adenomyosis lesion size change, to explore the effect of high intensity focused ultrasound in the treatment of adenomyosis.Methods: Select 277 cases of patients with adenomyosis.Given the ablation of high intensity focused ultrasound. Half a year after treatment were followed by color Dopper ultrasound examination,observation of adenomyosis of lesion size,follow-up clinical symptoms,therapeutic effect evaluation.Results:1.In 277 patients there were no serious adverse reaction.After treatment,the total efficiency was 97.8%.2.Six months after treatment, adenomyosis lesion size improvement rate and dysmenorrheal symptom improvement rate were 97.8% and 97.8%,he menstruation increase improvement rate was 100%.(P<0.05,the difference was statistically significant.)Key words:focused ultrasound treatment; adenomyosis; curative effect【中图分类号】R445 【文献标识码】A子宫腺肌症，是因子宫内膜腺体及间质侵入子宫肌层导致的疾病。
hifu系统技术参数
hifu系统技术参数HIFU系统（高强度聚焦超声）是一种可以实现非侵入性治疗的医疗设备，它利用聚焦超声波的能量来对特定区域进行治疗，广泛应用于肿瘤治疗、皮肤紧致、除皱、疤痕修复等领域。
本文将介绍HIFU系统的技术参数和相关参考内容。
首先，HIFU系统的技术参数包括频率、功率、焦点大小、治疗深度等。
其中频率通常在1-10 MHz范围内，功率可以调节，通常在100-200 W之间。
焦点大小和治疗深度决定了治疗的精确性和适用范围。
在参考内容方面，目前有许多研究和临床试验论文可以作为参考，以下是一些相关内容摘要：1. "High-Intensity Focused Ultrasound for the Treatment of Solid Tumors: A Review"（2018）- 该综述系统地回顾了HIFU在实体肿瘤治疗中的应用。
此文介绍了不同类型的肿瘤治疗、HIFU系统的原理和技术参数、治疗效果和并发症等方面的研究。
2. "Non-Invasive Facial Rejuvenation with High-Intensity Focused Ultrasound"（2019）- 该研究报道了使用HIFU系统进行非侵入性面部紧致和皮肤抗衰老治疗的结果。
研究者通过调整HIFU系统的焦点大小和功率，获得了良好的面部轮廓效果和减少细纹的效果。
3. "High-Intensity Focused Ultrasound Therapy for the Treatmentof Uterine Fibroids: A Systematic Review and Meta-Analysis"（2017）- 这篇系统评价总结了应用HIFU系统治疗子宫肌瘤的临床研究。
通过分析多项临床试验的数据，发现HIFU系统在缓解症状、改善生活质量和子宫肌瘤体积缩小方面具有显著的效果。
高强度超声聚焦治疗子宫肌瘤147例临床观察
脱气自来水加热至 36. 5℃ ～ 37. 5℃ ，实用焦点（ 0. 5 ～ 0. 6 cm × 0. 5 ～ 0. 6 cm × 0. 6 ～ 0. 9 cm） ，用点点成线累积矩阵方式治 疗较大的肌瘤。常用的治疗数据包括以下主要参数： （ 1） 输出 功率值为 0. 8 ～ 1. 8 kW。（ 2） 单元发射时间（ t1） 指每次发射 脉冲串的持续时间，一般在 0. 13 ～ 0. 24 s。（ 3） 占空时间（ t2） 指二次发射之间的间歇时间，t2： tl = （ 1 ～ 2） ： 1。（ 4） 每点次数 （ T） 指完成一个点治疗需要的发射总次数，一般在 35 ～ 55 次。 上述参数视瘤体层次深浅及瘤组织密度和声吸收率适当进行 调整。实际治疗中的治疗点的划分和焦点的位移在自控状态 下由计算机自动划分进行。 1． 3 适应证 凡经 2 次以上 B 超和妇检诊断为子宫肌瘤且 不需要生育的患者，机载 B 超能观察到肌瘤大小范围者。所 有患者术前均需行宫颈涂片检查、早孕试验阴性、无连续 3 个 月以上服用避孕药或非甾体药物史。有腹部、盆腔手术史者 需检查手术瘢痕，若瘢痕严重或瘢痕在超声束通道内则不适 合此项治疗。 1. 4 治疗方法 所有患者月经干净后 3 ～ 7 d，有节育环者取 环后再做治疗。术前向患者详尽告知 HIFU 治疗的原理及注 意事项、签署知情同意书、完善必要的常规检查和生化检查； 根据治疗需要作必要的肠道准备和膀胱充盈。治疗前行会 阴、前腹壁备皮，范围由耻骨联合上缘至脐水平。因此项治疗 对妊娠有害，并有导致子宫破裂的危险，治疗当天患者再做妊 娠试验。
2（ 1. 3）
52（ 35. 4） 20（ 13. 5）
总计
21（ 14. 3） 94（ 63. 9） 32（ 21. 8） 147（ 100）
基于合理信念替代疗法的心理护理对
[12]王晓英，高学军，王欣.围产期助产士整体护理对孕产妇分娩方式改善作用[J].河北医药，2021，43（14）：2224-2226.[13] XIAOKAI H，YAOZENG X，LEI Y，et al.Doppler ultrasoundevaluation of the efficacy of high intensity focused ultrasound in treatment of cesarean section scar pregnancy[J].Journal of the College of Physicians and Surgeons--Pakistan：JCPSP，2020，30（4）：240-244.[14]侯幸岳，许小明，钟际香，等.剖宫产后再次妊娠产妇分娩方式决策的最佳证据总结[J].中华现代护理杂志，2020，26（11）：1411-1417.[15]李娅男，黄丽君，赵红花.剖宫产后再次妊娠孕妇分娩方式相关知识，态度，行为状况调查及分娩方式影响因素分析[J].中国妇幼保健，2020，35（7）：1319-1322.（收稿日期：2022-08-30） （本文编辑：冯乐乐）*基金项目：兰州大学第二医院“菁英科技创新”计划项目（CY2019-HL16）①兰州大学第二医院 甘肃 兰州 730030②灵台县人民医院基于合理信念替代疗法的心理护理对肝硬化患者负面情绪、满意度的影响*张婧① 乔亚妮② 唐仲玲①【摘要】 目的：探讨基于合理信念替代疗法的心理护理对肝硬化患者负面情绪、满意度的影响。
方法：选取兰州大学第二医院2020年1月-2021年12月收治的88例肝硬化患者，按随机数字表法分为两组，即对照组44例采用常规护理，观察组44例于常规护理基础上采用基于合理信念替代疗法的心理护理；比较两组负面情绪、心理痛苦情况，统计患者对本次护理的满意度。
结果：观察组干预8周后焦虑、抑郁情绪及心理痛苦度评分均低于对照组，护理满意度（95.45%）高于对照组的68.18%，差异均有统计学意义（P <0.05）。
热疗技术治疗椎间盘源性疾病的研究进展
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孢菌素，其常见并发症为椎间隙感染以及术后复发等。 Ｍａｓａｌａ等¨７１作了一项回顾性研究，分别从患者视觉模拟疼 痛评分、止痛药的使用和脊柱功能状况方面评价髓核成形术 的效果，结果显示髓核成形术能有效缓解疼痛、减少止痛药 的使用，而且不影响脊柱的功能和稳定性。若严格选择适应 证并注意手术操作和无菌原则，髓核成形术的并发症很少 见。尽管目前的研究证明髓核成形术是一种治疗椎间盘源性 疾病安全有效的微创新手术，但其远期效果需要更多的随机 对照前瞻性研究来证明。
万方数据
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脂质体的稳定性研究及稳定策略
脂质体的稳定性研究及稳定策略摘要：脂质体作为药物传递系统, 在生物医学和药学领域中倍受青睐。
针对其化学、物理稳定性方面，国内外学者进行了大量研究，本文就其研究方法和已有的提高其稳定性的策略进行概述。
关键词：脂质体；稳定性；磷脂；粒径Abstract: The Liposome, as a drug delivery system, is widely acclaimed in the biomedical and pharmaceutical fields. In terms of its chemical and physical stabilities, domestic and foreign scholars have conducted a lot of research. The present review is aimed to overview those research methods and common strategies to improve the stability of liposomes.Keywords: Liposomes; Stability; Phospholipid;Particle size1 引言脂质体（Liposomes）是磷脂分散在水中形成的类球状的、包封一部分水相的、有单层或多层脂质双分子层的封闭囊泡。
其基本组成包括磷脂和胆固醇，药物包封或镶嵌在泡囊中构成脂质体制剂。
脂质体属于热力学不稳定体系，脂质的微粒形态、分布、相转变温度、动电电位的大小、流体学性质等显著影响其物理稳定性，而脂质的氧化、水解等是限制其化学稳定的主要因素，因而脂质体的稳定性研究在脂质体制剂的开发中具有重要现实意义。
据Chang等[1]的统计数据，截至2012年，已批准上市的12种注射脂质体制剂中4种为冻干固体制剂，包括AmBisome、Amphotec、Myocet、visudyne，说明其液体制剂的长期稳定性问题可能尚未能很好解决。
高强度聚焦超声辐照猪胰腺实验研究
生皮肤烧伤，头结肠坏死或穿孔，头胃豁膜损伤; 中等能量组4 头猪胰腺凝固性坏死程度较轻， 2 4 1 头发生结肠坏死;低能量组胰腺组织凝固性坏死不明显， 但电镜下可见细胞器损伤， 周后出现胰腺 1 坏死现象， 未发生皮肤、 胃及结肠损伤;未放置水囊组 4 头猪中只有 I 头光镜下见胰腺点状坏死 ， 皮 肤、 胃及结肠的损伤较放置水囊组明显加重。结论 通过胃内放置水囊的方法可有效改善猪胰腺 HIFU 超声通道， 高能量 HIFU辐照猪胰腺更易发生凝固性坏死， 但对胃、 结肠的损伤较重; 中低能量 HIFU 可引起猪胰腺发生多种形式损伤或坏死， 损伤程度相对较轻， 但相对安全。 【 关键词】 高强度聚焦超声; 胰腺; 胃肠系统 Radiation of high intensity focused ultrasound to pig pancreas : experimental study XIONGLiu-lin ’ ，
中 医 超 杂 电 版) 2007 年I 月第4 卷第1期C J M U 华 学 声 志( 子 hin ed ltrasound (Electr nic V o ersion) , February2007, V 4, N ol o.1
15
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高强度 聚焦超 声辐 照猪胰腺实 验研 究
熊六林 黄晓波 费兴波 于晋生 ， 玉秋红 薛卫成 郑珠颖 王晓峰 【 摘要】 目 探讨改善 的 胰腺HIFU辐照 超声通道的 方法， 解不同 并了 能量HI即 辐照 对猪胰腺
组织的损伤及对胃肠道的影响。方法 以2 头新鲜离体猪胰腺和 16 头在体猪胰腺体部为靶 目 ， 标 活 体实验中， HIFU 辐照前在 12 头猪胃内放置球囊并注人 800 一 1200 ml 脱气水， 分别以高、 低能量 中、
《运动损伤康复治疗学》第2版出版
Chinese Journal of Rehabilitation Medicine,Nov.2020,Vol.35.No.l1[15]Connolly B,O'Neill B,Salisbury L,et al.Physical rehabilitation interventions for adult patients during critical illness：an overview of systematic reviews[J].Thorax,2016,71(10):881—890.[16]Fink H,Helming M.Unterbuchner C,et al.Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness[J].Crit Care Med.2008,36(3)：910—916.[17]Wollersheim T,Haas K,Wolf S,et al.Whole body vibration to prevent intensive care unit acquired weakness:safety,feasibility,and metabolic response[J].Crit Care,2017,21(1):9.[18]倪莹莹，王首红,宋为群，等•神经重症康复中国专家共识(下)[J].中国康复医学杂志，2018,33⑶：264—268.[19]Hodgson C,Bellomo R,Bemey S,et al.Early mobilization and recovery in mechanically ventilated patients in the ICU:a bi-national,multicentre,prospective cohort study [J].Crit Care,2015,19(1):81.[20]Schweickert WD,Pohlman MC,Pohlman AS,et al.Early physical and occupational therapy in mechanically ventilated,critically ill patients:a randomized controlled trial[J].Lancet,2009,373(9678)：1874—1882.[21]Inoue S,Hatakeyama J,Kondo Y,et al.Post-intensivecare syndrome:its pathophysiology,prevention,and future directions[J].Acute Med Surg,2019,6(3):233一246.[22]Jung B,Moury PH,Mahul M,et al.Diaphragmatic dysfunction in patients with ICU-acquired weakness and its impact on extubation failure[J].Intensive Care Medicine, 2016,42(5):853—861.[23]Menezes KKP,Nascimento LR,Polese JC,et al.Effectof high-intensity home-based respiratory muscle training on strength of respiratory muscles following a stroke:a protocol for a randomized controlled trial[J].Brazilian Journal of Physical Therapy,2017,21(5):372—377.[24]Yoo HJ,Pyun SB.Efficacy of bedside respiratory muscletraining in patients with stroke:a randomized controlled tri-al[J].Am J Phys Med Rehabil,2018,97(10):691—697. [25]Penuelas O,Frutos-Vivar F,Fernandez C,et al.Characteristics and outcomes of ventilated patients according to time to liberation from MV[J].American Journal of Respiratory &Critical Care Medicine.2011,184(4):430—437.[26]Solverson KJ,Grant C,Doig CJ.Assessment and predictors of physical functioning post-hospital discharge in survivors of critical illness[J].Ann Intensive Care,2016.6(1)：92.[27]McWilliams D,Weblin J,Atkins G,et al.Enhancing rehabilitation of mechanically ventilated patients in the intensive care unit：A quality improvement project[J].J Crit Care,2015,30(1):13—18.《运动损伤康复治疗学》第2版出版王予彬和王惠芳教授主编的《运动损伤康复治疗学》第2版出版了。
聚焦超声治疗CINⅡ的临床疗效及价值
聚焦超声治疗CINⅡ的临床疗效及价值张艳;蓝幼叶【摘要】Objective To evaluate the efficacy and safety of high intensity focused ultrasound in the treatment of moderate cervical intraepithelial neoplasia by high intensity focused ultrasound in the treatment of cervical intraepithelial neoplasia. Methods Convenient selection from September 2014 to September 2015 for patients with moderate cervical intraepithelial neoplasia in our hospital were divided into two groups, the high intensity focused ultrasound treatment of 128 cases of mod-erate cervical intraepithelial neoplasia patients as the observation group, with cervical LEEP treatment of 157 patients with moderate cervical intraepithelial neoplasia patients as control group, and their clinical data were retrospectively analyzed. Results 128 cases in the observation group were treated by high intensity focused ultrasound for 3 months, and the results were normal. After 6 months of treatment, the cervical fluid based cytology test was normal. After treatment, the patients had no adverse reactions, and the cervix returned to normal, and no scar was formed. The control group of 157 patients after LEEP treatment 3 months follow-up colposcopy, 108 cases of patients with cervical smooth, 49 patients with mild cervical erosion patients, cervical biopsy under colposcope, 3 cases results for mild cervical intraepithelial neoplasia; after 6 months after treatment, cervical liquid based cytology, 154 cases were normal, 3 cases suggest that low grade squamous intraepithe-lial lesion. Conclusion For childless, cervicalunsatisfied exposure, heart disease LEEP surgery for patients,high intensity focused ultrasound is a safe and effective method for the treatment of moderate cervical intraepitalial neoplasia.%目的：通过高能聚焦超声治疗宫颈中度上皮内瘤变,探讨其临床疗效,从而评价高能聚焦超声治疗宫颈中度上皮内瘤变的有效性和安全性。
高强度聚焦超声治疗变应性鼻炎的疗效观察
Advances in Clinical Medicine 临床医学进展, 2023, 13(4), 5835-5840 Published Online April 2023 in Hans. https:///journal/acm https:///10.12677/acm.2023.134824高强度聚焦超声治疗变应性鼻炎的疗效观察邹天添1，陈丽鸿1，张愈正2，江文莉1，江 洪1*1重庆医科大学附属永川医院，耳鼻咽喉头颈外科，重庆 2四川省科学城医院，耳鼻咽喉头颈外科，四川 绵阳收稿日期：2023年3月13日；录用日期：2023年4月9日；发布日期：2023年4月18日摘 要目的：观察探讨高强度聚焦超声在变应性鼻炎疾病的诊疗过程中体现的疗效及优势。
方法：根据治疗意愿将175例变应性鼻炎患者分为3组，其中高强度聚焦超声组A 组58例，免疫治疗B 组65例，药物治疗组C 组52例。
三组之间两两比较观察对比患者的鼻部症状及临床治疗有效率。
结果：随访1年三组患者鼻痒、喷嚏、流清涕、鼻塞各症状评分差异，C 组高于A 组高于B 组(P < 0.05)。
随访1年，总有效率B 组89.2%高于A 组77.6%高于C 组55.8% (χ2 = 30.36, P < 0.01)。
结论：变应性鼻炎患者分别使用聚焦超声治疗、脱敏治疗及药物治疗疗效均较好；但是高强度聚焦超声治疗相较于脱敏治疗及药物治疗具有便捷、可重复性、生理负担轻等优点和安全性高的优点，三者疗效相辅相成，可在临床工作中结合患者特征将三者灵活搭配运用，为治疗变应性鼻炎提供新思路。
关键词高强度聚焦超声，变应性鼻炎，免疫治疗，药物治疗Effect Observation of High-Intensity Focused Ultrasound in Treatment of Allergic RhinitisTiantian Zou 1, Lihong Chen 1, Yuzheng Zhang 2, Wenli Jiang 1, Hong Jiang 1*1Department of Otolaryngology Head and Neck Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing 2Department of Otolaryngology Head and Neck Surgery, Sichuan Science City Hospital, Mianyang SichuanReceived: Mar. 13th , 2023; accepted: Apr. 9th , 2023; published: Apr. 18th , 2023AbstractObjective: To observe and discuss the efficacy and advantages of high intensity focused ultrasound in*通讯作者。
分析逆向调强放射治疗(IMRT)肺癌患者的临床观察
分析逆向调强放射治疗 (IMRT)肺癌患者的临床观察【摘要】目的探讨逆向调强放射治疗（IMRT）肺癌的临床疗效。
方法随机选取2018年3月-2021年10月本院68例肺癌患者，按照治疗方法分组，每组各34例，对照组与观察组分别采取三维适形放射治疗与逆向调强放射治疗，对比治疗效果。
结果治疗总有效率和不良反应发生率方面，观察组分别是79.41%与8.82%，对照组分别是55.88%与29.41%，观察组比对照组治疗总有效率高，而不良反应发生率较对照组低（P<0.05）。
结论肺癌疾病临床治疗过程中，逆向调强放射治疗方法的应用有助于患者临床症状减轻，提高治疗效果，而且能够尽量降低不良反应发生率，值得临床采纳、推广。
【关键词】肺癌；逆向调强放射治疗；三维适形放射治疗[Abstract] Objective To investigate the clinical efficacy of inverse intensity modulated radiation therapy (IMRT) for lung cancer. Methods 68 patients with lung cancer in our hospital from March 2018 to October 2021 were randomly pided into two groups, with 34 cases in each group. The control group and the observation group were treated with three-dimensional conformal radiotherapy and reverse intensity modulated radiotherapy respectively, and the treatment effects were compared. Results in terms of the total effective rate and the incidence of adverse reactions, the observation group were 79.41% and 8.82% respectively, and the control group were 55.88% and 29.41% respectively. The total effective rate of the observation group was higher than that of the control group, and the incidence of adverse reactions was lower than that of the control group (P < 0.05). Conclusion in the clinical treatment of lung cancer, the applicationof inverse intensity modulated radiation therapy can not only reducethe clinical symptoms of patients, improve the treatment effect, but also reduce the incidence of adverse reactions as far as possible,which is worthy of clinical adoption and promotion.[Key words] lung cancer; Inverse intensity modulated radiation therapy; Three dimensional conformal radiotherapy肺癌是临床发生率较高的一种恶性肿瘤，非小细胞肺癌在肺中中占比超过85%【1】。
高强度聚焦超声消融治疗子宫肌瘤的临床评价
高强度聚焦超声消融治疗子宫肌瘤的临床评价沈忠兵;朱向明;倪观太;江峰;刘表虎【期刊名称】《皖南医学院学报》【年(卷),期】2014(33)6【摘要】Objective:To evaluate the clinical efficacy and safety of high-intensity focused ultrasound ( HIFU) by precise positioning for ablation of hyste-romyoma.Methods:By precise positioning and applying real-time monitoring system(JC-type),52 patients with hysteromyoma (87 myomas) underwent ablation at the location of the focal field.One month after treatment,enhanced MRI was performed to determine the ablation rate for the target fibroids,and plain MRI was applied to evaluate the focal size reduction 6 months and 12 months after invention,respectively.The patients were also followed up for the changes of the menstruation and hemoglobin level.Results:The ablation rate of target fibroids was (83.2±13.6)% within one month after treatment.Six months and twelve months after treatment,the size of target fibroids was significantly reduced[(56.04 ±23.65)%;(70.00 ±21.26)%,respectively], and the menstrual blood volume was reduced,whereas hemoglobin level was elevated.The difference was significant(all P <0.05).No serious intra-or post-operative complications occurred.Conclusion:Under sedation analgesia,high-focused ultrasound by precise positioning for ablation of the hysteromyo-ma can be safe and efficacious.%目的：评价高强度聚焦超声（ HIFU）精确定位消融治疗子宫肌瘤的临床效果。
高强度聚焦超声消融术用于子宫肌瘤治疗的临床效果评价
高强度聚焦超声消融术用于子宫肌瘤治疗的临床效果评价陈美美;张幼红;魏苍梅;魏成胜【摘要】目的研究高强度聚焦超声消融术用于子宫肌瘤治疗的临床效果.方法研究资料来源于我院2014年3月~2015年12月收治子宫肌瘤患者70例,根据随机数字表法,分为2组,消融组和手术组.手术组给予传统子宫肌瘤剔除术治疗;消融组给予高强度聚焦超声消融术治疗.就两组患者治疗前后经期时间、月经量、Hb水平进行比较,并对两组患者子宫肌瘤治疗总有效率、并发症发生率、术后两组患者的生存质量指标进行比较.结果消融组子宫肌瘤治疗总有效率明显高于手术组,P<0.05.消融组手术并发症发生率低于手术组,P<0.05.治疗前两组经期时间、月经量、Hb水平无显著差异,P>0.05.治疗后消融组患者经期时间、月经量、Hb水平均明显优于手术组,P<0.05.术后消融组患者生存质量各项指标均优于手术组,P<0.05.结论高强度聚焦超声消融术用于子宫肌瘤治疗的临床效果确切,可有效改善患者临床症状,促进月经复常,有利于减少并发症的发生,促进患者术后生存质量的提升,值得推广.【期刊名称】《现代诊断与治疗》【年(卷),期】2017(028)001【总页数】3页(P32-34)【关键词】高强度聚焦超声消融术;子宫肌瘤;临床效果【作者】陈美美;张幼红;魏苍梅;魏成胜【作者单位】五华县妇幼保健院妇产科,广东五华 514400;五华县妇幼保健院妇产科,广东五华 514400;五华县妇幼保健院妇产科,广东五华 514400;五华县妇幼保健院妇产科,广东五华 514400【正文语种】中文【中图分类】R737.33子宫肌瘤为女性肿瘤常见多发类型之一，其在30～50岁女性中发生率较高，多数以失眠焦虑、月经不调、尿频尿急、痛经等为临床表现，对正常生活造成严重影响。
临床上子宫肌瘤的治疗方法较多，以手术方法为常见，但手术可带来较大的创伤，临床应用受限［1，2］。