1 THE DEVELOPMENT OF CIRCULATION CELL STRUCTURES IN GRANULAR MATERIALS UNDERGOING COMPRESSI

合集下载

细胞形态学英语

细胞形态学英语

细胞形态学英语Cell MorphologyCells are the fundamental units of life, and understanding their structure and function is essential for comprehending the complex processes that govern living organisms. Cell morphology, or the study of cell shape and structure, is a critical aspect of cell biology that provides valuable insights into the roles and behaviors of different cell types. This essay will explore the various aspects of cell morphology, including the different shapes and structures observed in different cell types, the functional significance of these characteristics, and the techniques used to study cell morphology.One of the most striking features of cell morphology is the diversity of cell shapes observed across different cell types. Cells can range from the simple, spherical shape of red blood cells to the highly complex and branched structures of neurons. The shape of a cell is largely determined by its internal cytoskeleton, a network of protein filaments that provide structural support and facilitate the movement of organelles and other cellular components.Certain cell shapes are particularly well-suited to the specificfunctions of the cell. For example, the long, slender shape of nerve cells, or neurons, allows them to efficiently transmit electrical signals over long distances. The flattened, disk-like shape of red blood cells, on the other hand, maximizes their surface area-to-volume ratio, enabling them to efficiently transport oxygen and carbon dioxide throughout the body.In addition to cell shape, the internal structure and organization of cells also play a crucial role in their function. Cells contain a variety of specialized organelles, each with its own unique structure and purpose. For instance, the mitochondria, the "powerhouses" of the cell, have a distinctive, folded inner membrane that increases the surface area for the process of cellular respiration. Similarly, the nucleus, which houses the cell's genetic material, is typically a spherical or ovoid structure surrounded by a double-layered membrane.The study of cell morphology involves a range of techniques, including light microscopy, electron microscopy, and advanced imaging technologies. Light microscopy, which uses visible light to magnify and observe cells, is a widely used tool in cell biology. This technique allows researchers to study the overall shape and structure of cells, as well as the distribution and arrangement of organelles within the cell.Electron microscopy, on the other hand, uses a beam of electrons to produce high-resolution images of cellular structures. This technique can reveal the intricate details of cell morphology, including the fine structure of organelles and the organization of the cytoskeleton. Electron microscopy has been instrumental in advancing our understanding of cell biology, as it has enabled researchers to visualize cellular structures at a level of detail that is not possible with light microscopy.In addition to these traditional microscopy techniques, advances in imaging technology have led to the development of new tools for studying cell morphology. Techniques such as confocal microscopy, which uses a focused laser beam to create high-resolution, three-dimensional images of cells, and super-resolution microscopy, which can achieve resolutions beyond the diffraction limit of light, have provided researchers with unprecedented insights into the structure and organization of cells.The study of cell morphology has far-reaching implications for our understanding of biology and medicine. By understanding the relationship between cell structure and function, researchers can gain valuable insights into the underlying mechanisms of various biological processes, from cellular signaling and metabolism to tissue development and disease pathogenesis.For example, changes in cell morphology can be indicative of various disease states. Cancer cells, for instance, often exhibit abnormal shapes and structural features, such as enlarged nuclei and irregular cell borders, which can be used as diagnostic markers. Similarly, the morphological changes observed in neurodegenerative diseases, such as Alzheimer's disease, can provide clues about the underlying pathological processes.In addition to its diagnostic applications, the study of cell morphology has also informed the development of new therapeutic strategies. By understanding the structural and functional characteristics of different cell types, researchers can design targeted interventions that specifically address the needs of particular cell populations. This has led to the development of novel drug delivery systems, tissue engineering approaches, and regenerative medicine therapies.In conclusion, the study of cell morphology is a critical aspect of cell biology that provides valuable insights into the structure and function of living organisms. From the diverse shapes and structures observed across different cell types to the advanced imaging technologies used to study them, the field of cell morphology continues to evolve and inform our understanding of the fundamental processes of life. As we continue to unravel the mysteries of cell biology, the study of cell morphology willundoubtedly play a crucial role in advancing our knowledge and improving our ability to address a wide range of medical and biological challenges.。

细胞生物学课件英文版-简介、显微镜

细胞生物学课件英文版-简介、显微镜
– Recent evidence indicates that prokaryotes are more diverse and numerous than previous thought.
Basic Properties of Cells (6)
• Types of Eukaryotic Cells: Cell Specialization
– Genes encode information to build each cell, ad the organism.
– Genes encode information for cellular reproduction, activity, and structure.
Levels of cellular and molecular organization
Pathways of cell differentiation
composition and metabolic features that have been conserved throughout evolution.
Basic Properties of Cells (2)
Basic Properties of Cells (3)
• Cells Posses a Genetic Program and the Means to Use It
– Cultured cells are an essential tool for cell biologists.
Basic Properties of Cells (2)
• Cells Are Highly Complex and Organized
– Cellular processes are highly regulated. – Cells from different species share similar structure,

(完整版)药学英语第五版原文翻译

(完整版)药学英语第五版原文翻译

Introduction to PhysiologyIntroductionPhysiology is the study of the functions of living matter. It is concerned with how an organism performs its varied activities: how it feeds, how it moves, how it adapts to changing circumstances, how it spawns new generations. The subject is vast and embraces the whole of life. The success of physiology in explaining how organisms perform their daily tasks is based on the notion that they are intricate and exquisite machines whose operation is governed by the laws of physics and chemistry.Although some processes are similar across the whole spectrum of biology—the replication of the genetic code for or example—many are specific to particular groups of organisms. For this reason it is necessary to divide the subject into various parts such as bacterial physiology, plant physiology, and animal physiology.To study how an animal works it is first necessary to know how it is built. A full appreciation of the physiology of an organism must therefore be based on a sound knowledge of its anatomy. Experiments can then be carried out to establish how particular parts perform their functions. Although there have been many important physiological investigations on human volunteers, the need for precise control over the experimental conditions has meant that much of our present physiological knowledge has been derived from studies on other animals such as frogs, rabbits, cats, and dogs. When it is clear that a specific physiological process has a common basis in a wide variety of animal species, it is reasonable to assume that the same principles will apply to humans. The knowledge gained from this approach has given us a great insight into human physiology and endowed us with a solid foundation for the effective treatment of many diseases.The building blocks of the body are the cells, which are grouped together to form tissues. The principal types of tissue are epithelial, connective, nervous, and muscular, each with its own characteristics. Many connective tissues have relatively few cells but have an extensive extracellular matrix. In contrast, smooth muscle consists of densely packed layers of muscle cells linked together via specific cell junctions. Organs such as the brain, the heart, the lungs, the intestines, and the liver are formed by the aggregation of different kinds of tissues. The organs are themselves parts of distinct physiological systems. The heart and blood vessels form the cardiovascular system; the lungs, trachea, and bronchi together with the chest wall and diaphragm form the respiratory system; the skeleton and skeletal muscles form the musculoskeletal system; the brain, spinal cord, autonomic nerves and ganglia, and peripheral somatic nerves form the nervous system, and so on.Cells differ widely in form and function but they all have certain common characteristics. Firstly, they are bounded by a limiting membrane, the plasma membrane. Secondly, they have the ability to break down large molecules to smaller ones to liberate energy for their activities.生理学简介介绍生理学是研究生物体功能的科学。

细胞生物学Introduction of cell biologyPPT课件

细胞生物学Introduction of cell biologyPPT课件

Cell organelle (Mitochondria, Chloroplasts, Endomembrane
system, nucleus etc.)
Cytoskeleton System
Cell proliferation and regulation
Cell differentiation and gene expression Cell apoptosis and cellular aging
structure
function
molecular mechanisms of the intricate activities of cells
细胞生物学是: 研究细胞基本 生命活动规律 的科学,它从 不同层次上主 要研究……
The structure of cells
第1页/共48页
The course mainly covers:
第3页/共48页
第4页/共48页
Suggestions to Study Cell Biology
Fundamental Concepts and theories Experimental approaches and ideas (As you read this
text, think like a researcher)
Reductionist (knowledge of the parts of the whole can
explain the character of the whole) Don’t accept everything you read as being true. Remain skeptical! English is just a tool! Take notes when you listened especially what I have emphasized

瞬时受体电位通道C3、C6在高血压发病中的作用

瞬时受体电位通道C3、C6在高血压发病中的作用

瞬时受体电位通道C3、C6在高血压发病中的作用摘要高血压是最常见的慢性病,发病机制复杂,Ca2+活动异常是其发生的重要机制之一。

作为非电压依赖的钙离子通道,瞬时受体电位通道C亚家族(TRPC)参与细胞凋亡、血管收缩、血小板激活及心肌肥厚等多种生理病理过程,而TRPC3和TRPC6与原发性高血压关系密切,在作用机制上与高血压传统发病机制存在区别,是目前研究中广泛采用的研究对象。

本文对TRPC3、TRPC6分子在高血压发病中的作用及相关进展进行综述。

关键词瞬时受体电位通道高血压钙通道中图分类号:R544.1 文献标识码:A 文章编号:1006-1533(2015)24-0021-04The role of the transient receptor potential channel C3 and C6 in the development of hypertensionJIN Pingping1,WANG Yajuan1,WANG Yan2,ZHANG Hongmei1,ZHANG Xuanzhao1,CHEN Liqing1,QIAN Yuesheng2,CHEN Ling1(1.Xinzhuang Community Health Service Center of Minhang District,Shanghai 201199,China;2.Ruijing Hospital Affiliated to School ofMedicine,Shanghai Jiao Tong University,Shanghai200025,China)ABSTRACT Hypertension is the most common chronic disease,its pathogenesis is complex,and the abnormal Ca2+ activity is one of the important mechanisms. As anon-voltage-dependent calcium channel,the transient receptor potential channel(TRPC)C3 and C6 participate in many physiological and pathological processes,such as the cell apoptosis,vasoconstriction,platelet activation and cardiac hypertrophy. The TRPC3 and TRPC6 are closely related to the primary hypertension;however,in the mechanism of the action,there is difference in the traditional pathogenesis of hypertension. They are widely used as the objects in the present research. This paper summarizes the roles of TRPC3 and TRPC6 and the related progress in the pathogenesis of hypertension.KEY WORDS transient receptor potential channel;hypertension;calcium channel高血压是最常见的慢性病,是多种心脑血管疾病的重要病因,同时也是导致心血管疾病死亡的主要原因之一[1],积极防治高血压是广受关注的重要课题。

细胞增殖英文CellReproduction课件

细胞增殖英文CellReproduction课件
1. What does “diploid” mean? 2. We have __ total chromosomes. 3. In the term 2n, what does “n” stand for in us?
In a gypsy moth? 4. Why does mitosis occur? Major functions? 5. In what cells (general term) does mitosis
• Groups of single-chromatid chromosomes reach poles of cell
• Nuclear envelop begins to reform
• 2 new daughter cells formed
• Cytokinesis begins with appearance of cell plate
It would be a genetic mess!
Instead, gametes are haploid (n).
Egg and sperm both have exactly half the number of chromosomes of somatic cells
At fertilization, n + n = 23; 23 + 23 = 46!
THE STEPS OF MITOSIS
• Interphase
(actually, this is not part of mitosis itself)
• Prophase • Metaphase • Anaphase • Telophase
Interphase
Onion root tip

课程简介模板.doc

课程简介模板.doc

1.课程简介课程名称:生理学课程时间:第2学期课程安排: 总课时数 116科目授课学时数理论课 80实验 36总课时 116课程简介:生理学作为天津市留学生英语教学品牌课程和双语示范课程,目标是培养掌握基础知识与基础理论、具有基本实验技能、具有分析与解决问题能力和创新精神的高素质医学留学生。

生理学是研究机体各种生命现象及其活动规律的一门科学,是医学生完成正常人体形态学课程后首次接触的功能学科,内容涉及人体各系统、各重要器官的重要生理功能及其功能活动调节的原理。

通过对各章节重要的生理学概念、各器官的主要生理功能的学习理解,使学生全面整体地认识人体各种结构与功能之间的联系;通过生理实验训练学生的基本技能,培养学生的医学逻辑思维、分析综合能力和创新意识。

人体生理学作为医学专业的主干基础课程,是药理学、病理生理学及临床各学科的重要功能科学基础,对后续学科的学习起到至关重要的作用。

COURSE INTRODUCTIONName of Course: PhysiologyTime of Course: The 2nd semesterCurriculum arrangement: Total teaching hours 116Subject Teaching hoursLecture 80Experiment 36Total 116COURSE DESCRIPTION:As the Municipal Brand Course of Tianjin for International Students in English and the Excellent Bilingual Model Course, the aim of our Physiology Course is to cultivate high quality medical students with abilities of mastering the basic medical knowledges and theories, the basic experiment skills, the competence in analyzing and solving problems and the creative spirit. Physiology is a science of studying various kinds of life phenomena and their law of activities, and is a subject about body function that students first contact after they complete the nomal Human Morphology courses. The contents include the important physiological functions of every human body system, organs, as well as the principle of regulation on their activities.Through the learning and comprehending of important physiological concepts and the main physiological functions of different organs in each chapter, students are enabled to fully understand the relationship between the structure and function of human body. Physiological experiments are used to train students' basic skills, cultivate the students' ability of medical logic thinking, analyze the comprehensive competence and innovation consciousness. The Human Physiology as the main basic course of medical science is an important foundation of Pharmacology, Pathophysiology and related Clinical Sciences. It plays a crucial role in the study of the following subjects in the medical education for overseas students.2. 教学大纲Syllabus of PhysiologyDepartment of Physiology2016.4Syllabus of Pathophysiology(For International Students)PREFACEThis syllabus is based on the outline of Physiology teaching for international medical students. The overall objective of this curriculum is to provide the basic principles of Physiology.THEORYChapter 1 IntroductionPurpose and Requirement:1. To master the concepts of physiology.2. To understand the fundamental characteristics of life phenomena3. To study the regulation of body function.4. To master feedback control systemTeaching Contents:1. Physiology is a science that studies the vital regularity in living organisms.2. Basic characteristics of life phenomena: metabolism, excitability and reproduction.3. The concept of internal environment and homeostasis.4. Regulation of body function and homeostasis: nervous regulation, hormonal regulation and autoregulation.5. The concept of feedback regulation: negative feedback and positive feedback.6. Two ways and 3 levels for study of physiology.Part 1. Research contents and methods of Physiology1. The development of modern physiologyKnowing the important events in the history of Physiology and understanding the research object and task of physiology.2. Different levels of physiological researchAble to know the significance of studying body function from the overall level, the organ and system levels as well as cell and molecular levels.3. Research methods of PhysiologyPart 2. Basic characteristics of life1. Metabolism: Can explain the related physiological phenomena with the theory of metabolism.2. Excitability: The concept and significance of excitability.3. Reproduction: Can explain the important meaning of reproduction.4. Adaptability:Be able to explain the phenomenon of adaptation。

一大波CNS级别单细胞文章等你来读

一大波CNS级别单细胞文章等你来读

⼀⼤波CNS级别单细胞⽂章等你来读眨眼睛我们单细胞天地⼜持续输出了⼀年,但是我们团队毕竟不是科研服务公司,没有⼈付费养着我们做研发。

所以现有团队实在是时间和精⼒实在是有限,尤其是单细胞领域⾼速飞奔,C N S⽂章发表的速度远超我们能提供的详细解读速度!我们团队收集整理了2G的单细胞⽂献P D F⽂件,但是各种云盘总是封杀这样的资源链接,我们也很难办。

所以呢,希望把这些⽂献分享给真正有需要的⼈。

你只需要按照我们的⽂献领读要求,解读任意⼀篇单细胞相关⽂章,并且发邮件给我,就可以拿到全部的2G的单细胞⽂献P D F ⽂件啦!我的邮箱是:jm z eng1314@163.c om其实我们是想招募⽂献分享创作者啦,你懂的!⽂献领读分享标准⾸先必须要有⽂章发表于年份,以及杂志,标题这样的开头然后是摘要使⽤哪种单细胞转录组技术,测下多少个样品,多少个细胞重点发现是什么(细胞亚群,还是特殊通路)正⽂5个重点⾸先是样品,建库测序,R N A-s eq上游分析概况然后是质量控制情况,最后的表达矩阵是多少个基因多少个细胞接着介绍作者是如何挑选重要的基因和降维降维后的聚类以及对每个类的注释类的下游分析(差异分析或者实验验证等)最后总结⼀下这个研究的发现了什么,意义是什么。

点出它的特⾊。

我们收集的⽂献有A d evel o p men t al l an d scap e o f3D-cu l t u r ed h u man p r e-g ast r u l at i o nemb r yo s.P M I D:31830756发表期刊:N at u r e影响因⼦:43.07M u l t i-o mi cs p r o f i l i n g o f mo u se g ast r u l at i o n at si n g l e-cel l r eso l u t i o n.P M I D:31827285发表期刊:N at u r e影响因⼦:43.07发表时间:2019 D ec 11A S p at i o t emp o r al O r g an-W i d e G en e E xp r essi o n an d C el l A t l as o f t h eD evel o p i n g H u man H ear t.P M I D:31835037发表期刊:C el l.影响因⼦:36.216发表时间:2019 D ec 12S i n g l e-cel l mu l t i o mi c an al ysi s i d en t i f i es r eg u l at o r y p r o g r ams i n mi xed-p h en o t yp e acu t e l eu kemi a.P M I D:31792411发表期刊:N at B i o t ech n o l影响因⼦:31.864发表时间:2019 D ec2I mmu n e p r o f i l i n g o f h u man t u mo r s i d en t i f i es C D73 as a co mb i n at o r i al t ar g et i n g l i o b l ast o ma.P M I D:31873309发表期刊:N at M ed影响因⼦:30.641发表时间:2019 D ec 23S i n g l e cel l t r an scr i p t o me an al ysi s r eveal s d i sease-d ef i n i n g T cel lsu b set s i n t h e t u mo r mi cr o en vi r o n men t o f cl assi c H o d g ki n l ymp h o ma.P M I D:31857391发表期刊:C an cer D i sco v影响因⼦:26.37发表时间:2019 D ec 19L o ss o f A D A M T S19 cau ses p r o g r essi ve n o n-syn d r o mi c h ear t val ved i sease.P M I D:31844321发表期刊:N at G en et影响因⼦:25.455发表时间:2019 D ec 16C D4+T C el l H el p I s R eq u i r ed f o r t h e F o r mat i o n o f a C yt o l yt i c C D8+T C el l S u b set t h at P r o t ect s ag ai n st C h r o n i c I n f ect i o n an d C an cer.P M I D:31810883发表期刊:I mmu n i t y影响因⼦:21.522发表时间:2019 D ec 17H i c1 D ef i n es Q u i escen t M esen ch ymal P r o g en i t o r S u b p o p u l at i o n s w i t h D i st i n ct F u n ct i o n s an d F at es i n S kel et al M u scl e R eg en er at i o n.P M I D:31809738发表期刊:C el l S t em C el l.影响因⼦:21.464发表时间:2019 D ec 5D esi g n an d ap p l i cat i o n o f si n g l e-cel l R N A seq u en ci n g t o st u d y ki d n ey i mmu n e cel l s i n l u p u s n ep h r i t i s.P M I D:31853010发表期刊:N at R ev N ep h r o l影响因⼦:19.684发表时间:2019 D ec 18U si n g si n g l e-cel l t ech n o l o g i es t o map t h e h u man i mmu n e syst em -i mp l i cat i o n s f o r n ep h r o l o g y.P M I D:31831877发表期刊:N at R ev N ep h r o l.影响因⼦:19.684发表时间:2019 D ec 12T h e p o w er o f o n e:ad van ces i n si n g l e-cel l g en o mi cs i n t h e ki d n ey.P M I D:31819231发表期刊:N at R ev N ep h r o l.影响因⼦:19.684发表时间:2019 D ec 9G en et i c p r ed i sp o si t i o n t o mo sai c Y ch r o mo so me l o ss i n b l o o d.P M I D:31748747发表期刊:N at u r e影响因⼦:43.07发表时间:2019 N o v 20I n vi t r o cu l t u r e o f cyn o mo l g u s mo n key emb r yo s b eyo n d ear l yg ast r u l at i o n.P M I D:31672918发表期刊:S ci en ce影响因⼦:41.037发表时间:2019 N o v 15M o d el i n g t h e E vo l u t i o n o f H u man B r ai n D evel o p men t U si n g O r g an o i d s.P M I D:31778651发表期刊:C el l影响因⼦:36.216发表时间:2019 N o v 27B C el l s an d T F o l l i cu l ar H el p er C el l s M ed i at e R esp o n se t o C h eckp o i n t I n h i b i t o r s i n H i g h M u t at i o n B u r d en M o u se M o d el s o f B r east C an cer.P M I D:31730857发表期刊:C el l影响因⼦:36.216发表时间:2019 N o v 14C l o n alD eco mp o si t i o n an d D N A R ep l i cat i o n S t at es D ef i n ed b y S cal ed S i n g l e-C el l G en o me S eq u en ci n g.P M I D:31730858发表期刊:C el l影响因⼦:36.216发表时间:2019 N o v 14G en et i c I d en t i f i cat i o n o f V ag al S en so r y N eu r o n s T h at C o n t r o l F eed i n gP M I D:31730854发表期刊:C el l影响因⼦:36.216发表时间:2019 N o v 14C l o n al l y E xp an d ed T C el l s R eveal I mmu n o g en i ci t y o f R h ab d o i d T u mo r s.P M I D:31708437发表期刊:C an cer C el l影响因⼦:23.916发表时间:2019 N o v 7S i n g l e-C el l R N A S eq u en ci n g R eso l ves S p at i o t emp o r al D evel o p men t o fP r e-t h ymi c L ymp h o i d P r o g en i t o r s an d T h ymu s O r g an o g en esi s i n H u man E mb r yo sP M I D:31604687发表期刊:I mmu n i t y影响因⼦:21.522发表时间:2019 N o v 19A si n g l e-cel l at l as o f en t o r h i n al co r t ex f r o m i n d i vi d u al s w i t h A l z h ei mer's d i sease r eveal s cel l-t yp e-sp eci f i c g en e exp r essi o n r eg u l at i o n.P M I D:31768052发表期刊:N at N eu r o sci影响因⼦:21.126发表时间:2019 N o v 25M ap p i n g mi cr o g l i a st at es i n t h e h u man b r ai n t h r o u g h t h e i n t eg r at i o n o f h i g h-d i men si o n al t ech n i q u es.P M I D:31740814发表期刊:N at N eu r o sci影响因⼦:21.126发表时间:2019 N o v 18A T p p p3+P d g f r a+t en d o n st em cel l p o p u l at i o n co n t r i b u t es t or eg en er at i o n an d r eveal s a sh ar ed r o l e f o r P D G F si g n al l i n g i nr eg en er at i o n an d f i b r o si s.P M I D:31768046发表期刊:N at C el l B i o l影响因⼦:17.728发表时间:2019 N o v 25O r g an o i d si n g l e-cel l g en o mi c at l as u n co ver s h u man-sp eci f i c f eat u r es o f b r ai n d evel o p men t.P M I D:31619793发表期刊:N at u r e.影响因⼦:43.07发表时间:2019 O ct16D i ssect i n g p r i mat e ear l y p o st-i mp l an t at i o n d evel o p men t u si n g l o n g-t er m i n vi t r o emb r yo cu l t u r e.P M I D:31672917发表期刊:S ci en ce.影响因⼦:41.037发表时间:2019 O ct31S p at i o t emp o r al i mmu n e z o n at i o n o f t h e h u man ki d n ey.P M I D:31604275发表期刊:S ci en ce.影响因⼦:41.037发表时间:2019 S ep27L an d scap e an d D yn ami cs o f S i n g l e I mmu n e C el l s i n H ep at o cel l u l arC ar ci n o ma.P M I D:31675496发表期刊:C el l.影响因⼦:36.216发表时间:2019 O ct31G en er at i o n o f B l ast o cyst-l i ke S t r u ct u r es f r o m M o u se E mb r yo n i c an dA d u l t C el l C u l t u r es.P M I D:31626770发表期刊:C el l.影响因⼦:36.216发表时间:2019 O ct17M u l t i mo d al A n al ysi s o f C el l T yp es i n a H yp o t h al ami c N o d e C o n t r o l l i n g S o ci al B eh avi o r.P M I D:31626771发表期刊:C el l.影响因⼦:36.216L o cal l y i n st r u ct ed C X C R4h i n eu t r o p h i l s t r i g g er en vi r o n men t-d r i venal l er g i c ast h ma t h r o u g h t h e r el ease o f n eu t r o p h i l ext r acel l u l ar t r ap s.P M I D:31591573发表期刊:N at I mmu n o l.影响因⼦:23.53发表时间:2019 O ct7S i n g l e C el l S eq u en ci n g o f M o u se H ear t I mmu n e I n f i l t r at e i n P r essu r eO ver l o ad-D r i ven H ear t F ai l u r e R eveal s E xt en t o f I mmu n e A ct i vat i o n.P M I D:31661975发表期刊:C ir c ulat ion.影响因⼦:23.054发表时间:2019 O ct30T r an scr i p t i o n al A t l as o f I n t est i n al I mmu n e C el l s R eveal s t h atN eu r o p ep t i d e α-C G R P M o d u l at es G r o u p 2 I n n at e L ymp h o i d C el lR esp o n ses.P M I D:31618654发表期刊:I mmu n i t y.影响因⼦:21.522发表时间:2019 O ct15T C F-1-C en t er ed T r an scr i p t i o n al N et w o r k D r i ves an E f f ect o r ver su sE xh au st ed C D8 T C el l-F at e D eci si o n.P M I D:31606264发表期刊:I mmu n i t y.影响因⼦:21.522发表时间:2019 O ct7S i n g l e-C el l R N A S eq u en ci n g R eso l ves S p at i o t emp o r al D evel o p men t o f P r e-t h ymi c L ymp h o i d P r o g en i t o r s an d T h ymu s O r g an o g en esi s i n H u man E mb r yo s.P M I D:31604687发表期刊:I mmu n i t y.影响因⼦:21.522发表时间:2019 O ct3I n vi vo C R I S P R scr een i n g i n C D8 T cel l s w i t h A A V–S l eep i n g B eau t yh yb r i d vect o r s i d en t i f i es memb r an e t ar g et s f o r i mp r o vi n g i mmu n o t h er ap y f o r g l i o b l ast o maP M I D:31548728发表期刊:N at B i o t ech n o l.影响因⼦:31.864发表时间:2019 S ep23T h e p h en o t yp es o f p r o l i f er at i n g g l i o b l ast o ma cel l s r esi d e o n a si n g l eaxi s o f var i at i o n.P M I D:31554641发表期刊:C an cer D i sco v.影响因⼦:26.37发表时间:2019 S ep25D at a d en o i si n g w i t h t r an sf er l ear n i n g i n si n g l e-cel l t r an scr i p t o mi cs.P M I D:31471617发表期刊:N at M et h o d s.影响因⼦:28.467A p o o l ed si n g l e-cel l g en et i c scr een i d en t i f i es r eg u l at o r y ch eckp o i n t s i n t h e co n t i n u u m o f t h e ep i t h el i al-t o-mesen ch ymal t r an si t i o n.P M I D:31477929发表期刊:N at G en et.影响因⼦:25.455A ct i vat i o n o f H ed g eh o g S i g n al i n g P r o mo t es D evel o p men t o f M o u se an d H u man E n t er i c N eu r al C r est C el l s,B ased o n si n g l e-cel l T r an scr i p t o meA n al yses.P M I D:31442438发表期刊:G ast r o en t er o l o g y.影响因⼦:19.233发表时间:2019 A u g20I n t er l eu ki n 1 b et a an d M at r i x M et al l o p ep t i d ase 3 C o n t r i b u t e t oD evel o p men t o fE GF R-d ep en d en t S er r at ed P o l yp s i n M o u se C ecu mP M I D:31470007发表期刊:G ast r o en t er o l o g y.影响因⼦:19.233发表时间:2019 A u g27S i n g l e-cel l t r an scr i p t i o n al an al yses o f sp asmo l yt i c p o l yp ep t i d e-exp r essi n g met ap l asi a ar i si n g f r o m acu t e d r u g i n j u r y an d ch r o n i ci n f l ammat i o n i n t h e st o mach.P M I D:31481545发表期刊:G u t.影响因⼦:17.943发表时间:2019 S ep3A l ar g e p o o l o f act i vel y cycl i n g p r o g en i t o r s o r ch est r at es sel f-r en ew alan d i n j u r y r ep ai r o f an ect o d er mal ap p en d ag e.P M I D:31481792发表期刊:N at C el l B i o l影响因⼦:17.728发表时间:2019 S epD i ver si f i cat i o n an d C X C R4-D ep en d en tE st ab l i sh men t o f t h e B o n e M ar r o w B-1a C el l P o o l G o ver n s A t h er o p r o t ect i ve I g M P r o d u ct i o n L i n ked T oH u man C o r o n ar y A t h er o scl er o si sP M I D:31549940发表期刊:C i r c R es.影响因⼦:15.862.R eco n st i t u t i n g t h e t r an scr i p t o me an d D N A met h yl o me l an d scap es o fh u man i mp l an t at i o nP M I D:31435013发表期刊:N at u r e影响因⼦:43.07发表时间:2019 A u g21C o n ser ved cel l t yp es w i t h d i ver g en t f eat u r es i n h u man ver su s mo u seco r t exP M I D:31435019发表期刊:N at u r e影响因⼦:43.07发表时间:2019 A u g21L o cal l y r en ew i n g r esi d en t syn o vi al macr o p h ag es p r o vi d e a p r o t ect i veb ar r i er f o r t h e j o i n tP M I D:31391580发表期刊:N at u r e影响因⼦:43.07发表时间:2019 A u g07C l o n al r ep l acemen t o f t u mo r-sp eci f i c T cel l s f o l l o w i n g P D-1 b l o ckad eP M I D:31359002发表期刊:N at M ed影响因⼦:30.641A t h er o p r o t ect i ve r o l es o f smo o t h mu scl e cel l p h en o t yp i c mo d u l at i o n an d t h e T C F21 d i sease g en e as r eveal ed b y si n g l e-cel l an al ysi sP M I D:31359001发表期刊:N at M ed影响因⼦:30.641发表时间:2019 Ju l29M o l ecu l ar mech an i sms o f l i n eag e d eci si o n s i n met ab o l i t e-sp eci f i c Tcel l s.P M I D:31431722发表期刊:N at I mmu n o l.影响因⼦:23.53发表时间:2019 A u g20A n N f i l3-Z eb2-I d2 p at h w ay i mp o ses I r f8 en h an cer sw i t ch i n g d u r i n g cD C1 d evel o p men tP M I D:31406377发表期刊:N at I mmu n o l影响因⼦:23.53发表时间:2019 A u g12S i n g l e-C el l S u r vey o f H u man L ymp h at i cs U n vei l s M ar ked E n d o t h el i al C el l H et er o g en ei t y an d M ech an i sms o f H o mi n g f o r N eu t r o p h i l sP M I D:31402260发表期刊:I mmu n i t y影响因⼦:21.522发表时间:2019 A u g01D ef i n i n g t h e I d en t i t y an d D yn ami cs o f A d u l t G ast r i c I st h mu s S t em C el l sP M I D:31422913发表期刊:C el l S t em C el l影响因⼦:21.464发表时间:2019 A u g08S i n g l e-cel l an al ysi s o f car d i o g en esi s r eveal s b asi s f o r o r g an-l eveld evel o p men t al d ef ect s.发表期刊:N at u r e.影响因⼦:43.07P M I D:31341279发表时间:2019 Ju l24R N A seq u en ci n g:t h e t een ag e year s.发表期刊:N at R ev G en et.影响因⼦:43.07P M I D:31341269发表时间:2019 Ju l24N eu r o n al vu l n er ab i l i t y an d mu l t i l i n eag e d i ver si t y i n mu l t i p l e scl er o si s.发表期刊:N at u r e.影响因⼦:43.07P M I D:31316211发表时间:2019 Ju l17A h u man l i ver cel l at l as r eveal s h et er o g en ei t y an d ep i t h el i al p r o g en i t o r s.发表期刊:N at u r e.影响因⼦:43.07P M I D:31292543发表时间:2019 Ju l10scS L A M-seq r eveal s co r e f eat u r es o f t r an scr i p t i o n d yn ami cs i n si n g l e cel l s.发表期刊:N at u r e.影响因⼦:43.07P M I D:31292545发表时间:2019 Ju l10S i n g l e-cel l an al ysi s r eveal s T cel l i n f i l t r at i o n i n o l d n eu r o g en i c n i ch es.发表期刊:N at u r e.影响因⼦:43.07P M I D:31270459发表时间:2019 Ju l03N eu t r o p h i l s D r i vi n g U n co n ven t i o n al T C el l s M ed i at e R esi st an ce ag ai n st M u r i n e S ar co mas an d S el ect ed H u man T u mo r s.发表期刊:C el l.影响因⼦:36.216P M I D:31257026发表时间:2019 Ju l11A n I n t eg r at i ve M o d el o f C el l u l ar S t at es,P l ast i ci t y,an d G en et i cs f o rG l i o b l ast o ma.发表期刊:C el l影响因⼦:36.216P M I D:31327527发表时间:2019 Ju l9E p i g en o mi cs an d S i n g l e-cel l S eq u en ci n g D ef i n e a D evel o p men t alH i er ar ch y i n L an g er h an s C el l H i st i o cyt o si s.发表期刊:C an cer D i sco v.影响因⼦:26.37P M I D:31345789发表时间:2019 Ju l25G en er at i o n o f H u man P S C-D er i ved K i d n ey O r g an o i d s w i t h P at t er n edN ep h r o n S eg men t s an d a D e N o vo V ascu l ar N et w o r k.发表期刊:C el l S t em C el l.影响因⼦:21.464P M I D:31303547C el l u l ar cr o sst al k i n t h e d evel o p men t an d r eg en er at i o n o f t h er esp i r at o r y syst em发表期刊:N A T R ev M ol c ell B iol影响因⼦:43.351P M I D:31217577发表时间:2019 J un 19I n d i vi d u al b r ai n o r g an o i d s r ep r o d u ci b l y f o r m cel l d i ver si t y o f t h e h u man cer eb r al co r t ex发表期刊:N at ur e影响因⼦:43.07P M I D:31168097发表时间:2019 J un 05O b esi t y r emo d el s act i vi t y an d t r an scr i p t i o n al st at e o f a l at er alh yp o t h al ami c b r ake o n f eed i n g发表期刊:S c ienc e影响因⼦:41.037P M I D:31249056发表时间:2019 J un 28C r o ss-sp eci es si n g l e-cel l an al ysi s o f p an cr eat i c d u ct al ad en o car ci n o mar eveal s an t i g en-p r esen t i n g can cer-asso ci at ed f i b r o b l ast s发表期刊:C anc er D is c ov影响因⼦:26.37P M I D:31197017发表时间:2019 J un 13T h e i mmu n e cel l l an d scap e i n ki d n eys o f p at i en t s w i t h l u p u s n ep h r i t i s发表期刊:N at I m m unol影响因⼦:23.53P M I D:31209404发表时间:2019 J un 17T r an scr i p t i o n al d yn ami cs o f p l u r i p o t en t st em cel l-d er i ved en d o t h el i al cel l d i f f er en t i at i o n r eveal ed b y si n g l e-cel l R N A seq u en ci n g发表期刊:E ur H ear t J影响因⼦:23.239P M I D:31242503发表时间:2019 J un 26S i n g l e C el l A n al ysi s o f t h e N o r mal M o u se A o r t a R eveal s F u n ct i o n al l yD i st i n ctE n d o t h el i al C el l P o p u l at i o n s发表期刊:C ir c ulat ion影响因⼦:23.054P M I D:31146585发表时间:2019 M ay31S i n g l e-C el l R N A S eq u en ci n g o f t h e T H el p er C el l R esp o n se t o H o u seD u st M i t es D ef i n es a D i st i n ct G en eE xp r essi o n S i g n at u r e i n A i r w ay T h2 C el l s发表期刊:I m m unit y影响因⼦:21.522P M I D:31231035发表时间:2019 J un 14S en so r y l esi o n i n g i n d u ces mi cr o g l i al syn ap se el i mi n at i o n vi a A D A M10 an d f r act al ki n e si g n al i n g.发表期刊:N at N eur os c i影响因⼦:21.126P M I D:31209379发表时间:2019 J un 17S i n g l e-cel l g en o mi cs i d en t i f i es cel l t yp e-sp eci f i c mo l ecu l ar ch an g es i n au t i sm.P M I D:31097668发表期刊:S c ienc e影响因⼦:41.058发表时间:2019-5-17I d en t i f i cat i o n o f a r eg en er at i o n-o r g an i z i n g cel l i n t h e X en o p u s t ai l.P M I D:31097661发表期刊:S c ienc e影响因⼦:41.058发表时间:2019-5-17T emp o r al p at t er n i n g o f ap i cal p r o g en i t o r s an d t h ei r d au g h t er n eu r o n s i n t h e d evel o p i n g n eo co r t ex.P M I D:31073041发表期刊:S c ienc e影响因⼦:41.058发表时间:2019-5-10A C el l u l ar T axo n o my o f t h eB o n e M ar r o w S t r o ma i n H o meo st asi s an dL eu kemi a.P M I D:31130381发表期刊:C ell影响因⼦:31.398发表时间:2019-5-23A d ap t i ve I mmu n e R esi st an ce E mer g es f r o m T u mo r-I n i t i at i n g S t em C el l sP M I D:31031009发表期刊:c ell影响因⼦:31.398发表时间:2019-4-25M ech an i sms o f l ymp h o ma cl ear an ce i n d u ced b y h i g h-d o se al kyl at i n gag en t sP M I D:31040105发表期刊:C anc er dis c ov er y影响因⼦:24.373发表时间:2019-4-30S i n g l e-C el l A n al ysi s o f t h e L i ver E p i t h el i u m R eveal s D yn ami cH et er o g en ei t y an d an E ssen t i al R o l e f o r Y A P i n H o meo st asi s an dR eg en er at i o n.P M I D:31080134发表期刊:C ell S t em C ell影响因⼦:23.29发表时间:2019-5-1Y A P,b u t N o t R S P O-L G R4/5,S i g n al i n g i n B i l i ar y E p i t h el i al C el l sP r o mo t es a D u ct u l ar R eact i o n i n R esp o n se t o L i ver I n j u r y.P M I D:31080135发表期刊:C ell S t em C ell影响因⼦:23.29发表时间:2019-5-7D ef i n i n g i n f l ammat o r y cel l st at es i n r h eu mat o i d ar t h r i t i s j o i n t syn o vi al t i ssu es b y i n t eg r at i n g si n g l e-cel l t r an scr i p t o mi cs an d mass cyt o met r y.P M I D:31061532发表期刊:nat ur e im m unology影响因⼦:21.809发表时间:2019-5-6A si n g l e-cel l at l as o f mo u se b r ai n macr o p h ag es r eveal s u n i q u et r an scr i p t i o n al i d en t i t i es sh ap ed b y o n t o g en y an d t i ssu e en vi r o n men t.P M I D:31061494发表期刊:nat ur e neur os c ienc e影响因⼦:19.912发表时间:2019-5-6H B E G F+macr o p h ag es i n r h eu mat o i d ar t h r i t i s i n d u ce f i b r o b l asti n vasi ven ess.P M I D:31068444发表期刊:S C I T r ans l M ed影响因⼦:16.71发表时间:2019-5-8。

关于干细胞与免疫细胞的临床应用的英语

关于干细胞与免疫细胞的临床应用的英语

干细胞与免疫细胞的临床应用1. IntroductionThe clinical application of stem cells and immune cells has been a topic of great interest and debate in the medical field. In recent years, there has been a growing body of research and development in the use of these cells for various medical conditions. In this article, we will explore the potential and challenges of using stem cells and immune cells in clinical settings.2. Understanding Stem CellsFirst, let's delve into the concept of stem cells. Stem cells are undifferentiated cells that have the ability to differentiate into specialized cell types. They are the foundation of development in multicellular organisms, and have the potential to repair, replace, or restore damaged tissues in the body. The use of stem cells in regenerative medicine has shown promise in treating a wide range of diseases and injuries.3. Clinical Applications of Stem CellsStem cell therapy has been studied and applied in various medical fields, including cardiology, neurology, orthopedics,and oncology. For example, in cardiology, stem cells have been used to regenerate cardiac tissue in patients with heart disease. In neurology, stem cell therapy offers potential treatments for conditions such as Parkinson's disease and spinal cord injuries. While there have been significant advancements in the clinical use of stem cells, challenges such as ethical considerations, safety, and regulation still need to be addressed.4. Exploring Immune CellsOn the other hand, immune cells play a critical role in the body's defense against infections and diseases. Different types of immune cells, such as T cells, B cells, and natural killer cells, have unique functions in the immune system. Harnessing the power of immune cells in clinical applications has the potential to revolutionize the treatment of cancer, infectious diseases, and autoimmune disorders.5. Immunotherapy and Cancer TreatmentOne of the most exciting developments in the field of immune cell therapy is the use of immunotherapy in cancer treatment. Immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy, have demonstrated remarkable success in treating certain types of cancer. By reprogramming a patient's ownimmune cells to recognize and attack cancer cells, immunotherapy offers a targeted and personalized approach to cancer treatment.6. Clinical Challenges and OpportunitiesDespite the significant progress in the clinical applications of stem cells and immune cells, there are still challenges that need to be ovee. These include the need for standardized protocols, long-term safety and efficacy data, and ethical considerations. Additionally, the high cost and accessibility of these treatments pose barriers to widespread implementation. However, with continued research and technological advancements, the potential for stem cell and immune cell therapy to transform medicine is undeniable.7. ConclusionIn conclusion, the clinical application of stem cells and immune cells holds immense potential for advancing the field of medicine. From regenerative medicine to cancer immunotherapy, these novel approaches have the power to revolutionize the way we treat and manage diseases. However, it is vital to approach this field with caution, ensuring that ethical, safety, and regulatory considerations are thoroughlyaddressed. As we continue to uncover the therapeutic capabilities of stem cells and immune cells, the future of medicine looks brighter than ever.8. Personal PerspectivePersonally, I find the intersection of stem cell and immune cell therapy to be a fascinating and promising area of research. The potential to harness the body's own healing mechanisms and immune defenses for clinical applications is a testament to the incredible potential of modern medicine. As we navigate theplexities of translating these scientific advancements into tangible treatments, I am hopeful that the collaboration between researchers, clinicians, and regulatory bodies will ultimately benefit patients in need of innovative therapies.。

四章细胞周期thecellcycle

四章细胞周期thecellcycle
一、 細胞分裂扮演之角色 (The key roles of cell division):
2) 紡綞體微管體的聚合(assembly)是由中心體開始。 中 心 體 又 稱 為 微 管 體 聚 合 中 心 (microtubleorgnizing center)。在細胞環裂之靜止期,中心 體分裂為二,位於細胞核之外,在細胞分裂前期 或前中期(prometaphase),微管體從中心體向外 四散,兩個中心體排列在細胞相反的兩個極 (spindle poles)上。
CH4 細胞週期 (The Cell Cycle)
CH4 細胞週期 (The Cell Cycle)
一、 細胞分裂扮演之角色 (The key roles of cell division):
(三)細胞週期中有絲分裂與間期之交互進行 (Mitosis alternates with interphase in the cell cycle)
CH4 細胞週期 (The Cell Cycle)
三、 細胞週期的調控(regulation of cell cycle)
2. Cell cycle checkpoint
2) Maturation Promoting Factor C(MPF)包含二部份
B. cyclin

(a)呈韻律變化,在M-phase量最高。
三、 細胞週期的調控(regulation of cell cycle)
2. Cell cycle checkpoint 1) 微纖維母細胞(fibrob;ast cells)培養時若加 入PDGF(platelet-derived growth factor), 其細胞才會快速分裂,否則細胞不能分裂 (Fig.12.13)。

医学英语翻译

医学英语翻译

Introduction to the Developing Human人体发育生物学介绍Human development is a continuous process that begins when an oocyte (ovum) from a female is fertilized by a sperm (spermatozoon) from a male. Cell division, cell migration, programmed cell death, differentiation, growth, and cell rearrangement transform the fertilized oocyte, a highly specialized, totipotent cell, a zygote, into a multicellular human being. Although most developmental changes occur during the embryonic and fetal periods, important changes occur during later periods of development: infancy, childhood, adolescence, and early adulthood Development does not stop at birth. Important changes, in addition to growth, occur after birth (e.g., development of teeth and female breasts).人体的发育是一个连续的过程。

一开始,女性的卵子通过与男性的精子结合而完成受精,随后经过不断的细胞分裂、迁移、程序性死亡、分化、成熟和重排,受精卵这个高度特异性的全能细胞、合子,最终转变为一个多细胞组成的复杂的人体。

Cell Signaling Pathways in Development

Cell Signaling Pathways in Development

Cell Signaling Pathways in Development Cell signaling pathways are crucial in the development of organisms. These pathways are complex networks of biochemical reactions that enable cells to communicate with each other, allowing them to coordinate their activities and ultimately form tissues and organs. In this essay, we will explore the importance of cell signaling pathways in development from multiple perspectives.From a biological perspective, cell signaling pathways play a critical role in the development of an organism. During embryonic development, cells must differentiate and specialize into various cell types, such as muscle cells, nerve cells, and skin cells. This differentiation is controlled by signaling pathways that activate specific genes and proteins, leading to the development of specific cell types. For example, the Sonic Hedgehog pathway is essential for the development of the nervous system, while the Wnt pathway is crucial for the development of the digestive system. Without these signaling pathways, the development of an organism would be severely impaired.From a medical perspective, understanding cell signaling pathways is essential for the development of new treatments for various diseases. Many diseases, such as cancer, are caused by abnormalities in cell signaling pathways. By understanding these pathways, researchers can develop drugs that target specific proteins or genes involved in the pathway, leading to more effective treatments. For example, drugs that target the Epidermal Growth Factor Receptor (EGFR) pathway have been developed to treat various types of cancer, including lung cancer and breast cancer.From a philosophical perspective, the study of cell signaling pathways raises questions about the nature of life and the role of genetics in shaping our development. The fact that cells can communicate with each other and coordinate their activities to form complex organisms is a testament to the incredible complexity and beauty of life. Furthermore, the fact that our development is controlled by our genes raises questions about the extent to which we are predetermined by our genetic makeup. While our genes certainly play a significant role in shaping our development, it is also clear that environmental factors can have a profound impact on our development as well.From a social perspective, the study of cell signaling pathways has important implications for issues such as genetic engineering and stem cell research. The ability to manipulate cell signaling pathways raises the possibility of creating organisms with specific traits or curing diseases by replacing damaged or diseased cells with healthy ones. However, these technologies also raise ethical questions about the extent to which we should manipulate the genetic makeup of living organisms. Furthermore, the fact that these technologies are often expensive and only available to those with access to healthcare raises questions about social justice and the distribution of resources.From a personal perspective, the study of cell signaling pathways highlights the incredible complexity and interconnectedness of the human body. It is humbling to consider the vast number of signaling pathways that are involved in our development and the intricate ways in which they interact with each other. Furthermore, the fact that abnormalities in these pathways can lead to serious health problems underscores the importance of taking care of our bodies and seeking medical attention when necessary.In conclusion, cell signaling pathways are essential for the development of organisms and have important implications for medicine, philosophy, society, and personal health. By studying these pathways, we can gain a deeper understanding of the nature of life and the role of genetics in shaping our development. Furthermore, we can develop new treatments for diseases and explore the ethical implications of genetic engineering and stem cell research. Ultimately, the study of cell signaling pathways reminds us of the incredible complexity and interconnectedness of the human body and the importance of taking care of ourselves and each other.。

developmental cell的投稿经验

developmental cell的投稿经验

developmental cell的投稿经验
《发育细胞》(Developmental Cell)是一本由美国细胞生物学会出版的期刊,发表关于细胞生物学或发育生物学,包括信号传导、细胞增殖、极性、细胞迁移、细胞谱系和命运规范、染色质调节和功能、癌细胞生物学、进化生物学、疾病病因学、膜交通、代谢调节、形态发生和生物力学、器官发育、ncRNA、干细胞生物学和再生的研究。

投稿经验如下:- 期刊基本信息:由国际著名出版商CELL PRESS出版,每年发行12期,主编是来自英国的J. Ann Le Good教授。

目前期刊已被包括SCIE在内的众多数据库收录,ISSN号为1534-5807,eISSN号为1878-1551,JCR1区,中科院1区,最新影响因子13.417,五年影响因子13.294。

- 期刊分区:JCR1区,中科院大小类均为1区,TOP期刊。

- 收稿范围:包括其他(2226)、评论(871)、论著(502)、综述(236)、信件(21)等。

- 刊文量:每年300篇左右。

- 国人发文情况:从近些年的统计结果来看,国人在该期刊发文208篇,排名第五,仍有一定的发文空间。

- 审稿周期:平均8个月左右接受,整体来说发文速度中规中矩。

投稿时,建议作者关注期刊的官网信息和投稿要求,并确保稿件质量达到期刊的标准。

如果你还想了解关于投稿的更多细节,可以继续向我提问。

细胞生物学英语

细胞生物学英语

细胞生物学英语Cell Biology英语Cell Biology is a branch of biology that focuses on the study of cells, their structure, functions, and interactions with other cells. It plays a crucial role in understanding the fundamental principles of life and forms the basis for various medical and scientific advancements. In this article, we will explore the key concepts in cell biology and their importance in various fields of research.1. Introduction to Cell Biology1.1 Cell StructureEvery living organism is made up of one or more cells. Cells are the basic building blocks of life, and each cell is enclosed by a cell membrane, which separates the internal components from the external environment. The cell membrane maintains the integrity of the cell and controls the movement of molecules in and out of the cell.1.2 Cell TypesThere are two main types of cells in organisms: prokaryotic cells and eukaryotic cells. Prokaryotic cells, found in bacteria and archaea, lack a nucleus and membrane-bound organelles. On the other hand, eukaryotic cells, found in plants, animals, and fungi, have a nucleus and various specialized organelles, such as mitochondria and endoplasmic reticulum.2. Cell Functions2.1 Energy ProductionMitochondria are the powerhouses of the cell, responsible for generating energy in the form of ATP through cellular respiration. This process involves the breakdown of glucose and other nutrients to release energy. Energy produced by mitochondria is essential for the cell's metabolic activities.2.2 Protein SynthesisProteins are essential molecules involved in various cellular processes. Ribosomes, located in the cytoplasm and endoplasmic reticulum, synthesize proteins using information encoded in the DNA. This process, called translation, plays a vital role in cell growth, repair, and regulation.2.3 Cell SignalingCells communicate with each other through a complex network of signaling molecules. Signaling pathways, such as the receptor-ligand interaction, transmit signals inside the cell and coordinate responses, such as cell division, differentiation, and apoptosis. Dysregulation of cell signaling can lead to various diseases, including cancer.3. Techniques in Cell BiologyAdvancements in technology have revolutionized the field of cell biology, enabling scientists to study cells and their components in greater detail. Some widely used techniques include:3.1 MicroscopyMicroscopes are essential tools in cell biology, allowing scientists to visualize cells and subcellular structures. Light microscopy, electron microscopy, and confocal microscopy are commonly used techniques to observe cells at various levels of resolution.3.2 Cell CultureCell culture involves the growth and maintenance of cells outside their natural environment. It provides a controlled environment for studying cell behavior, development, and response to external stimuli. Cell culture has been instrumental in drug development and regenerative medicine research.3.3 Molecular Biology TechniquesTechniques like polymerase chain reaction (PCR), gel electrophoresis, and DNA sequencing have revolutionized the field of molecular biology. These techniques enable researchers to study cellular components, such as DNA, RNA, and proteins, and understand their roles in cellular processes.4. Applications of Cell Biology4.1 Medical ResearchCell biology has a tremendous impact on medical research and healthcare. It provides insights into the cellular mechanisms of diseases, facilitating the development of novel therapies and drugs. For example, understanding cancer at a cellular level has led to the development of targeted therapies that specifically target cancer cells while sparing normal cells.4.2 Tissue EngineeringCell biology plays a significant role in tissue engineering, a field that aims to repair or replace damaged tissues and organs. By utilizing the knowledge of cell behavior and interactions, scientists can grow artificial tissues and organs in the laboratory for transplantation or drug testing purposes.4.3 BiotechnologyCell biology is crucial in biotechnology, where living cells are used to produce valuable products. Genetic engineering techniques, such as recombinant DNA technology, allow scientists to modify cells to produce proteins, enzymes, and other useful compounds. This has applications in medicine, agriculture, and industrial processes.In conclusion, cell biology is a fascinating field that provides insights into the fundamental units of life. Through studying cells and their functions, researchers gain a deeper understanding of diseases, develop novel treatments, and make advancements in various scientific disciplines. As technology continues to advance, the future of cell biology holds even more exciting possibilities for the improvement of human health and the betterment of society.。

从细胞到奇点英文名字

从细胞到奇点英文名字

从细胞到奇点英文名字From Cells to SingularityThe journey from the microscopic world of cells to the enigmatic realm of singularity is a captivating exploration of the intricate tapestry of our universe. This odyssey encompasses the fundamental building blocks of life, the emergence of complex systems, and the potential for a future where the boundaries of our understanding are pushed beyond the limits of our imagination.At the heart of this journey lies the humble cell, the basic unit of all living organisms. These microscopic marvels possess an astounding complexity, housing a myriad of intricate structures and processes that sustain the delicate balance of life. From the intricate dance of molecules within the cell membrane to the intricate genetic code that dictates its very existence, the cell is a testament to the ingenious design of nature.As we delve deeper into the cellular realm, we uncover the remarkable mechanisms that govern the growth, division, and specialization of these fundamental units. The process of cellular differentiation, where a single cell gives rise to a diverse array ofspecialized cell types, is a testament to the adaptability and resilience of life. This phenomenon, observed across the vast spectrum of living organisms, from the simplest microbes to the most complex multicellular life forms, highlights the incredible versatility of the cellular blueprint.But the journey does not end there. As we venture beyond the confines of the cellular world, we encounter the emergence of complex systems – the building blocks of the larger structures that shape our world. From the intricate networks of neurons that give rise to the human mind to the vast ecosystems that sustain life on our planet, these complex systems demonstrate the remarkable ability of nature to self-organize and adapt to ever-changing environments.The exploration of these complex systems has led to the development of cutting-edge fields of study, such as systems biology and complexity theory. These disciplines delve into the intricate relationships and dynamics that govern the behavior of these intricate webs of interconnected components. By unraveling the underlying principles that govern these systems, we gain a deeper understanding of the fundamental forces that shape the world around us.As we continue to push the boundaries of our knowledge, theconcept of singularity emerges as a tantalizing possibility. Singularity, a hypothetical point in time when technological advancement and artificial intelligence surpass human capabilities, represents the potential for a transformative shift in the trajectory of our species and the very nature of our existence.The notion of singularity has captivated the imaginations of scientists, futurists, and philosophers alike, as it holds the promise of a future where the limitations of our current understanding are transcended. The prospect of a superintelligent entity, capable of self-improvement and exponential growth, raises profound questions about the nature of consciousness, the limits of human cognition, and the ethical implications of such a momentous transition.The journey from cells to singularity is not merely a linear progression but a complex and interconnected tapestry of discoveries, insights, and speculations. It is a testament to the boundless curiosity and ingenuity of the human mind, driven by an insatiable desire to unravel the mysteries of the universe and push the boundaries of what is possible.As we continue to explore this captivating journey, we are confronted with the realization that the path ahead is not without its challenges and uncertainties. The ethical and societal implications of technological advancements, the potential risks of uncontrolledartificial intelligence, and the delicate balance between human agency and technological autonomy are just a few of the pressing issues that demand our attention.Yet, in the face of these challenges, the journey from cells to singularity remains a beacon of hope and inspiration. It is a testament to the power of human imagination, the resilience of life, and the endless potential that lies within the fabric of our universe. As we continue to unravel the complexities of the natural world and push the boundaries of our understanding, we may just catch a glimpse of the extraordinary future that awaits us – a future where the boundaries between the infinitesimal and the infinite are blurred, and the very essence of our existence is transformed.。

三圈环流的基本纬度

三圈环流的基本纬度

三圈环流的基本纬度英文回答,The basic latitudes of the three-cell circulation are the equator, 30 degrees north, and 60 degrees north. These latitudes correspond to the locations of the three major circulation cells in each hemisphere: the Hadley cell, the Ferrel cell, and the Polar cell.The Hadley cell is located near the equator, between about 0 and 30 degrees latitude. In this region, the air at the surface is heated and rises, creating a low-pressure area. As the air rises, it cools and forms clouds,resulting in high levels of precipitation. The air then moves poleward at high altitudes, creating the trade winds.The Ferrel cell is located between 30 and 60 degrees latitude. In this region, the air from the Hadley cell descends and creates a high-pressure area. This causes the air to move towards the poles at the surface and towards the equator at high altitudes. The westerly winds, also known as the prevailing winds, are a result of thismovement.The Polar cell is located near the poles, between about 60 and 90 degrees latitude. In this region, the air at the surface is cold and dense, creating a high-pressure area. The air moves towards the equator, where it meets the warmer air of the Ferrel cell and is lifted, creating a boundary known as the polar front.Overall, these latitudes represent the key locations where the three-cell circulation pattern drives global atmospheric circulation and influences weather patterns around the world.中文回答,三圈环流的基本纬度是赤道、北纬30度和北纬60度。

developmentcell投稿经验

developmentcell投稿经验

developmentcell投稿经验作为一名职业写手,我深刻认识到开发细胞投稿对于科研工作者的重要性。

今天,我将与大家分享我的投稿经验,帮助大家在撰写稿件和选择期刊过程中更加得心应手。

首先,让我们谈谈稿件准备。

在撰写稿件时,请注意以下几点:1.确保内容严谨:文章应具有清晰的研究目的、可靠的数据、合理的分析以及明确的结论。

2.遵循期刊的格式要求:仔细阅读期刊的投稿指南,确保您的稿件符合格式要求,如字数、图表、引用规范等。

3.突出创新点:在稿件中明确指出您的研究与其他研究的区别,强调创新之处。

4.良好的写作风格:稿件应具备清晰的逻辑结构,简洁明了的文字,以及恰当的术语。

接下来,选择合适的期刊至关重要。

以下几点可供参考:1.研究领域匹配:选择与您的研究领域相符的期刊。

2.影响因子:查看期刊的影响因子,以评估其在学术界的地位和声誉。

3.发行周期:了解期刊的发行周期,以确保您的研究成果能够尽快与读者见面。

4.投稿经验:了解其他作者在该期刊的投稿经验,以便您能做好充分的心理准备。

在投稿过程中,与审稿人和编辑保持良好沟通至关重要。

以下是一些建议:1.认真对待审稿意见:审稿人是您的文章能否发表的关键人物,请务必认真对待他们的意见,并在修改稿件时充分回应。

2.保持礼貌和专业:在与审稿人和编辑沟通时,始终保持礼貌和专业,以提高合作氛围。

3.及时反馈:在修改稿件时,尽量按照审稿意见进行修改,并在规定时间内提交修订稿。

此外,增强文章的可读性和实用性也是提高投稿成功率的关键。

以下是一些建议:1.突出重点:在文章中,通过恰当的标题、摘要、关键词等方式,突出研究重点。

2.图文并茂:适当使用图表、图片等可视化元素,帮助读者更好地理解文章内容。

3.逻辑清晰:确保文章的结构和逻辑清晰,便于读者跟进和理解。

4.实证研究:在文章中提供具体的实证研究,以增加说服力。

最后,应对审稿反馈和提高投稿成功率的方法包括:1.多渠道投稿:同时向多个期刊投稿,以增加发表机会。

developmental biology 英文原版书

developmental biology 英文原版书

developmental biology 英文原版书【中英文版】The book "Developmental Biology" is a comprehensive guide that covers various aspects of developmental biology.It explores the intricate processes involved in the development of an organism, from fertilization to adulthood.The book delves into the molecular and cellular mechanisms that regulate growth, differentiation, and organ formation.发育生物学书籍是一本全面介绍发育生物学的指南。

它探讨了生物体从受精到成熟过程中的复杂过程。

这本书深入研究了调控生长、分化和器官形成的分子和细胞机制。

In addition to discussing the fundamental concepts, the book also presents the latest research findings in the field.It highlights the advancements in stem cell biology, genetic editing techniques, and the impact of environmental factors on development.The book is well-organized and divided into chapters that focus on different stages of development.除了讨论基本概念外,这本书还介绍了该领域的最新研究成果。

高级医学英语

高级医学英语

高级医学英语The Role of Stem Cell Therapy in Regenerative Medicine IntroductionStem cell therapy is a promising approach for regenerative medicine. The foundation for stem cell therapy lies in the unique characteristics of stem cells, which have the ability to differentiate into various cell types. The regenerative potential of stem cells has shown great potential for disease treatments, tissue and organ repair, and the development of new therapies. This article will provide an overview of stem cell therapy, its types, and its applications in regenerative medicine.Types of Stem CellsStem cells can be classified into two broad categories: embryonic stem cells and adult stem cells.Embryonic stem cells are derived from the inner cell mass of the blastocyst, which is a stage of embryonic development. Embryonic stem cells have the ability to differentiate into all three germ layers – the ectoderm, mesoderm, and endoderm. Mesenchymal stem cells and hematopoietic stem cells are examples of adult stem cells. Adult stem cells are undifferentiated cells that reside in various tissues throughout the body. These cells have the ability to differentiate into various cell types within their origin tissue. Adult stem cells can be found in the bone marrow, adipose tissue, blood, brain, heart, liver, and other tissues.Applications of Stem Cell Therapy in Regenerative MedicineStem cell therapy has the potential to treat a variety of conditions, including degenerative diseases, injuries, and genetic disorders. Some of the major applications of stem cell therapy include:1. Tissue EngineeringStem cells are used to engineer tissues for replacement or repair of damaged or diseased tissues. For example, stem cells can be used to regenerate bone, cartilage, muscle, and skin tissue.2. Cellular TherapyStem cells can be used to treat diseases by transplantation of healthy cells. The transplantation of hematopoietic stem cells is an example of cellular therapy. It is used to treat conditions such as leukemia, lymphoma, and other blood-related disorders.3. Regeneration of OrgansStem cells are used to regenerate organs that have lost their function due to injury or disease. Researchers are exploring the use of pluripotent stem cells to regenerate the pancreas, liver, and heart.4. Drug DevelopmentStem cells can be used to develop new drugs. Stem cells can be manipulated to form specific cell types that are affected by certaindiseases. These cells can be used to test new therapies for the disease.Challenges and LimitationsThe success of stem cell therapy depends on the type of cells used and the patient’s immune response to the cells. Some of the challenges and limitations of stem cell therapy include:1. Transplant RejectionStem cells transplanted from a donor can be rejected by the patient’s immune system. This can result in various complications, including graft-versus-host disease.2. Tumor FormationThe use of pluripotent stem cells can result in the formation of tumors. These cells have the ability to differentiate into all cell types, which makes them more prone to produce tumors.3. Ethical and Legal IssuesThe use of embryonic stem cells is controversial due to ethical and legal issues. The destruction of human embryos is required to obtain embryonic stem cells.ConclusionStem cell therapy has immense potential for regenerative medicine.Stem cells can differentiate into multiple cell types and can regenerate tissues and organs. Stem cell therapy has been successful in treating various conditions, including blood-related disorders, injuries, and degenerative diseases. The success of stem cell therapy depends on the type of cells used and the patient’s immune response to the cells. Further research is required to fully explore the potential of stem cell therapy in regenerative medicine.Stem cell therapy is a fast-evolving field in regenerative medicine. The potential of stem cells to differentiate into various cell types and regenerate tissues and organs has opened up new avenues for the treatment of several degenerative diseases, injuries, and genetic disorders. The ability of stem cells to repair damaged tissues and organs has given hope to millions of patients who suffer from various ailments.One of the significant applications of stem cell therapy is tissue engineering, which involves the creation of various types of tissue for the replacement or repair of damaged or diseased tissues. Tissue engineering is becoming increasingly important as the need for transplantable organs continues to grow worldwide. For example, researchers are exploring the use of stem cells to regenerate bone tissue to replace damaged or fractured bones. Stem cells can differentiate into bone-forming cells, which can help repair bone fractures and defects. Similarly, the use of stem cells to regenerate cartilage is being researched for the repair of cartilage injuries and joint degeneration.Stem cells are also being used in cellular therapy, which involves the transplantation of healthy cells to treat diseases. Hematopoietic stem cell transplantation is one of the most successful cellulartherapies used for the treatment of several blood-related disorders, including leukemia, lymphoma, and multiple myeloma. Hematopoietic stem cells can differentiate into various blood cells, including red blood cells, white blood cells, and platelets. They are usually harvested from the bone marrow or peripheral blood of the donor before being transplanted into the patient.Regeneration of damaged or diseased organs is another potential application of stem cell therapy. Researchers are exploring the use of pluripotent stem cells to regenerate organs that have lost their function due to injury or disease. The pancreas, liver, and heart are some of the organs being studied for the regeneration potential of stem cells. Pluripotent stem cells are immortal cells that can differentiate into any cell type in the body. The use of pluripotent stem cells can provide a potential cure for several diseases that were once thought incurable.Stem cells are also being used for drug development. Stem cells can be manipulated to form specific cell types that are affected by certain diseases. These cells can be used to test new therapies for the disease. This approach can significantly reduce the cost and time required for drug development. The use of stem cells in drug development can also reduce the need for animal testing, which has ethical concerns and limitations.Despite the vast potential of stem cells, there are several challenges and limitations to their use in regenerative medicine. One of the significant challenges is transplant rejection. Stem cells transplanted from a donor can be rejected by the patient’s immune system, leading to various complications, including graft-versus-host disease. The immune response of the patient depends on several factors, including the type of stem cells used, the patient’s immune system, and the method of transplantation.Another limitation of stem cell therapy is tumor formation. The use of pluripotent stem cells can result in the formation of tumors. These cells have the ability to differentiate into any cell type in the body, which makes them more prone to producing tumors. The risk of tumor formation can be reduced by carefully monitoring the differentiation of pluripotent stem cells and ensuring that only fully differentiated cells are used for transplantation.The use of embryonic stem cells is controversial due to ethical and legal issues. The destruction of human embryos is required to obtain embryonic stem cells. This has led to ethical concerns regarding the use of embryos for research purposes. However, recent scientific discoveries have shown that stem cells can also be obtained from adult tissues. Adult stem cells are undifferentiated cells that reside in various tissues throughout the body and can be harvested without ethical concerns.In conclusion, stem cell therapy has tremendous potential for regenerative medicine. The ability of stem cells to regenerate tissues and organs has given hope to millions of patients suffering from various diseases and injuries. However, there are several challenges and limitations to the use of stem cells in regenerative medicine, including transplant rejection, tumor formation, and ethical concerns. Further research is required to address these challenges and fully explore the potential of stem cell therapy in regenerative medicine. With continued research and development,stem cell therapy has the potential to revolutionize the field of medicine and provide new treatments for many currently incurable diseases.。

要了解单细胞测序技术,这8篇经典综述一定要看哦!

要了解单细胞测序技术,这8篇经典综述一定要看哦!

要了解单细胞测序技术,这8篇经典综述⼀定要看哦!今天我们继续介绍单细胞测序技术,这是“技术篇——单细胞测序”系列⽂章的第6期了,前⾯5期我们分别从:(1)科研热度(⽤这个技术发表的⽂章中,每4篇中就有1篇10分+,还不赶快了解⼀下!);(2-3)使⽤单细胞测序发表⾼分杂志的两个案例(⼀篇肿瘤领域的Science和⼀篇⼼⾎管领域的Circulation);(4)单细胞测序技术的常见问题(关于这个⾼⼤上技术的问题,这篇⽂章早就总结好了!);以及(5)如果我们经费预算不够,可以使⽤的两个数据库:⾃⼰做不起单细胞测序,别担⼼有数据库可以⽤啊!。

今天我们把中间遗漏的⼀期:单细胞测序的经典综述补上。

正好是假期,如果你不看球,可以静下⼼来看看⽂章。

废话不多说,我们直接上⽂献:1. Unravelling biology and shifting paradigms in cancer with single-cell sequencing.Nat RevCancer. 2017 Aug 24;17(9):557-569.这篇去年8⽉份发表在Nat Rev Cancer杂志上的综述主要从单细胞测序在肿瘤研究中的应⽤来展开,综述了单细胞测序的技术、在研究肿瘤异质性和基因组进化中的作⽤,并以肺癌为例说明了单细胞测序的应⽤场景:Single-cell sequencing for the decomposition of heterogeneous cellular populations and theanalysis of rare cells in lung cancerSingle-cell sequencing can be leveraged to study cancergenetics and biology at all stages ofdisease development.2. Single-cell RNA sequencing for the study of development, physiology and disease.Nat Rev Nephrol. 2018 May 22. doi: 10.1038/s41581-018-0021-7.今年5⽉22号发表在Nat Rev Nephrol杂志上的综述,主题是单细胞RNA测序在发育、⽣理和疾病研究中的应⽤,本⽂介绍了单细胞测序技术的流程、不同单细胞捕获⽅法、数据分析流程和软件,以及应⽤等等。

  1. 1、下载文档前请自行甄别文档内容的完整性,平台不提供额外的编辑、内容补充、找答案等附加服务。
  2. 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
  3. 3、如文档侵犯您的权益,请联系客服反馈,我们会尽快为您处理(人工客服工作时间:9:00-18:30)。

1.0 Introduction The macroscopic deformational behavior of a granular material is primarily due to the rearrangement of the individual particles. The particle interactions are governed by the mechanical and geometric properties of the particles, such as shape, size, roughness and contact stiffness. The ultimate goal of studying the micromechanics of granular systems is to provide insight into macroscopic phenomena, such as failure, by relating the microscopic properties to the appropriate macroscopic parameters [1], [2], [3], [4],[5]. Here we use the discrete element technique to characterize granular systems as a collection of rigid particles of different shapes and sizes with specified physical interaction properties and loading configurations [6]. The method provides us with a high degree of control over the simulations and allows access to detailed information about the behavior of each particle in the system.
1. Associate Professor of Civil Engineering Director, Intelligent Engineering Systems Laboratory e-mail: john@ 2. Research Assistant. e-mail: nrege@
2
n1=1.0 n2=1.0
n1=0.5 n2=0.5
n1=2.0, n2=2.0
FIGURE 1. Superquadric Shapes
The three specimens generated consist of discs, ellipses and diamonds. Each specimen consists of 845 particles with equal number of particles of three sizes of a particular shape. The size parameters and the superquadric parameters are given in Tables 1 and 2.
ABSTRACT
This paper predicts the formation of microstructures within a granular material undergoing biaxial compression. Using the discrete element method we test ensembles of particles of varying geometric shape and size. The tests predict that the motion of the particles deviates significantly from that predicted by continuum theory. The particles form localized coherent structures (here called circulation cells) in which groups of particles instantaneously behave as a rigid body. These circulation cells migrate and coalesce to form larger structures. Eventually a global shear band forms at the boundary of two or more of the circulation cells.
1
In this paper we describe numerical experiments using the discrete element method to study the behavior of an idealized two dimensional particulate system. We are particularly interested in understanding the conditions under which disturbances at the particle level grow to form macroscopic structures, such as shear bands. The experiments performed here focus on the biaxial compression of two dimensional particle ensembles consisting of different particle shapes under a constant confining stress. The experiments track the motion of each individual particle. The results of our numerical models predict the formation of coherent vortex like structures which we call circulation cells. A circulation cell is a group of particles which instantaneously translates and rotates as a rigid body. The presence of these cells is partially masked by the deformation due to the homogeneous strain. The cells become clearly visible when the homogeneous deformation is subtracted and the residual velocity is plotted. The results show that the formation and evolution of these coherent structures influences the global failure of the specimen. The setup used for the numerical simulations is described in Section 2. In Section 3, the observed macroscopic behavior for specimens of different particle shapes is described. In Section 4, particle trajectory plots showing the circulation cells are presented. Finally, the implications of the development of these coherent structures within a granular material are discussed. 2.0 Numerical Test Setup The experiments are performed using MIMES, a Discrete Element based simulation system developed by the authors [7], [8]. Compression tests are conducted on three different granular ensembles, each with a different characteristic particle shape. The shape in each ensemble is characterized by the superquadric function[9], [10] given by;
The particles are initially generated in a regular grid with random orientations as shown in Figure 2 (a). The particles are not touching when the specimen is generated. The particles are consolidated by moving the walls of the container inwards under a constant applied load. For each of the three specimens, we use the same compacting force on the platens. The consolidation process is continued until the specimen is in equilibrium as shown in Figure 2 (b). The different particle shapes offer different resistance to packing, which results in the specimens having different void ratios (discs 0.2, ellipses 0.24, diamonds 0.15) at the same confining preБайду номын сангаасsure. Figure 3 shows close-ups of the specimens after consolidation.
相关文档
最新文档