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盐酸氯哌斯汀JP检测方法

盐酸氯哌斯汀JP检测方法

盐酸氯哌斯汀日本药典15版和对映体C20H24ClNO.HCl:366.321-{2-[(RS)-(4-Chlorophenyl) phenylmethoxy]}piperidine monhydrochloride [14984-68-0]1-{2-[(RS)- (4-氯苯基) 苯甲氧基]}哌啶单盐酸盐盐酸氯哌斯汀,干燥时含有不少于98.5%的C20H24ClNO.HCl.性状盐酸氯哌斯汀为白色,结晶或结晶性粉末它非常易溶于水,甲醇,乙醇(95)和乙酸(100),并且溶于醋酸酐。

盐酸氯哌斯汀(1:10)的溶液显示出无旋光性。

鉴别(1)将盐酸氯哌斯汀溶解于0.1mol/L盐酸(1:2500)并测定溶液在紫外可见光谱<2.24>下的吸收光谱,并与参照谱1比较:两者应在同一波长显示出相似强度的吸收谱。

分别再测定盐酸氯哌斯汀溶解于0.1mol/L盐酸(1:62,500)溶液在紫外可见光谱<2.24>,并与参照谱2比较:两者应在同一波长显示出强度相似的吸收谱。

(2)测定红外吸收谱,取事先干燥的盐酸氯哌斯汀用氯化钾压片法测定红外吸收谱<2.25>,并与参照谱比较:两者应在同一波长数处显示出强度相似的吸收谱。

(3)在10mL的盐酸氯哌斯汀(1:100)的溶液中加入2mL 氨水溶液和20 mL的乙醚并振摇,静置后将水层分出,用20mL的乙醚洗涤水层,并过滤。

用稀硝酸酸化过滤液:可用氯含量测定法<1.09>检查该溶液。

熔点<2.60> 148 —152 o C纯度(1) 重金属<1.07> —根据方法2继续取用 1.0g盐酸氯哌斯汀,进行检验操作。

用2.0mL的标准铅溶液(不超过20ppm)准备对照溶液。

(2)相关物质—溶解40mg的盐酸氯哌斯汀于50mL的流动相,并用该溶液作为样品溶液。

移取1mL 样品溶液,精确加入流动相至200mL整,并使用此溶液作为标准溶液。

非索非那定片29页

非索非那定片29页
2020/3/29
上市信息
非索非那定fexofenadine,为一抗过敏药物, 于2019年上市后,相继在美国\澳大利亚、 澳地利、比利时、巴西、加拿大、丹麦、 芬兰、法国、德国、希腊、香港、印度、 日本、卢森堡、马来西亚、墨西哥、荷兰、 新西兰、挪威、葡萄牙、南非、西班牙、 瑞典、瑞士、泰国、英国等数十个国家和 地区上市,用于治疗过敏性鼻炎、荨麻疹 等过敏性疾病。
盐酸非索非那定片
----毕馨
【分子式】 C32H39NO4·HCl 【分子量】 538.13 【性状】 本品为薄膜衣片,除去包衣后显白色或类白色。
2020/3/29
上市信息
赫斯特公司开发,2019年首次在欧洲上市 2019年FDA批准了SANOFI AVENTIS的新 药申请 2019年10月FDA批准口服混悬剂
2020/3/29
适应症
季节性过敏性鼻炎 适用于缓解成人和6岁及6岁以上的儿童的 季节性过敏性鼻炎相关的症状。如打喷嚏, 流鼻涕,鼻、上腭、咽喉发痒,眼睛发痒、 潮湿、发红。
慢性特发性荨麻疹 适用于治疗成人和6岁及6岁以上儿童的慢 性特发性荨麻疹的皮肤症状,能够减轻瘙 痒和风团的数量。
2020/3/29
2020/3/29
毒性反应
急性毒性试验: 口服毒性低,小鼠和大鼠口服LD50均大于 5000mg/kg
亚急性毒性试验: 犬连续口服本品 100mg/kg28天,均未观 察到任何不良反应发生
2020/3/29
毒性反应
体内和体外试验结果表明,非索非那定没 有致癌性、致突变性
支物生殖毒性研究:当给予大鼠和家兔口 服特非那丁高达300mg/kg,它们产生的非 索非那定血浆AUC值分别相当于人体治疗值 (60mg,一日二次)的4倍和37倍,结果 均未发现有致畸的作用。

注射用硫普罗宁的制备与含量测定

注射用硫普罗宁的制备与含量测定

华西药学杂志W C J·P S 2008,23(4)ζ500~501素0.1004~1.5060μg,异补骨脂素0.0830~112450μg与峰面积积分呈良好的线性关系。

1.2.5 稳定性实验 吸取同一份供试品溶液10μl,每隔2h进样测定1次,考查6次,补骨脂素、异补骨脂素峰面积的RS D分别为0.6%、1.4%。

1.2.6 重复性试验 取同一批样品,平行试验6次,每份吸取10μl供试液,进样测定。

补骨脂素、异补骨脂素含量总和平均为20.262m g·g-1,RS D= 1.4%,表明有较好的重复性。

1.2.7 加样回收试验 精密称取已知含量(20.262 m g·g-1)的样品6份,分别加入1.0、2.0、3.0m l对照品溶液,按“11212”项处理后,进样测定,补骨脂素回收率为97.8%、RS D=1.92%;异补骨脂素回收率为98.5%、RSD=1.60%。

1.2.8 样品的测定 取6批样品,分别按“1.2.2”“11211”项处理测定,进样10μl;按外标峰面积法计算补骨脂素和异补骨脂素的总含量,结果6批样品的总含量分别为20.021、18.153、19.587、191368、201076、17.938m g·g-1(n=2)。

2 讨论补骨脂是青娥丸方中的主药,补骨脂具有温肾助阳、纳气、止泻的功能。

《中国药典》2005年版青娥丸项下无含量测定,所以我们采用HP LC法测定了青娥丸中补骨脂素和异补骨脂素的含量,方法简便、快速、准确,可控制青娥丸的质量。

参考文献:[1] 中华人民共和国国家药典委员会.中国药典[S].一部.北京:化学工业出版社,2005.129,487.[2] 陈发奎.常用中草药有效成分含量测定[M].北京:人民卫生出版社,1997.136.收稿日期:2008-01注射用硫普罗宁的制备与含量测定张敏娟(青海省药品检验所,青海西宁810000)摘要:目的 制备注射用硫普罗宁,并测定其含量。

Gelucire-14-44-SDS-MedChemExpress

Gelucire-14-44-SDS-MedChemExpress

Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Nov.-23-2018Print Date:Nov.-23-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Gelucire 14/44Catalog No. :HY-Y1892CAS No. :121548-04-71.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:N/AMolecular Weight:N/ACAS No. :121548-04-74. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Pure form-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Oil)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

安妥明的实验报告

安妥明的实验报告

一、实验目的1. 掌握安妥明的合成原理和方法。

2. 熟悉有机合成实验的基本操作步骤。

3. 提高实验操作技能,培养严谨的科学态度。

二、实验原理安妥明(Antipyrine)是一种常用的非甾体抗炎药,具有解热、镇痛、抗炎作用。

本实验采用对氯苯氧异丁酸与乙醇、盐酸反应制备安妥明。

三、实验材料与仪器1. 实验材料:对氯苯氧异丁酸、乙醇、盐酸、石油醚、甲苯、无水硫酸钠、无水碳酸钠、蒸馏水、氢氧化钠、碳酸氢钠。

2. 实验仪器:反应瓶、烧杯、玻璃棒、漏斗、滤纸、滤器、蒸发皿、电热套、冷凝管、回流冷凝管、液封装置、温度计、紫外灯。

四、实验步骤1. 对氯苯氧异丁酸的制备:将无水硫酸钠放入反应瓶中,加入对氯苯氧异丁酸,再加入无水碳酸钠。

将反应瓶置于电热套上,加热至100℃,回流反应2小时。

冷却后,将反应液倒入烧杯中,用滤纸过滤,滤液用无水碳酸钠中和至中性。

将中和后的溶液倒入烧杯中,加入无水硫酸钠,过滤,滤液用无水碳酸钠中和至中性。

将中和后的溶液倒入烧杯中,加入无水硫酸钠,过滤,滤液用无水碳酸钠中和至中性。

2. 安妥明的制备:将上述滤液倒入反应瓶中,加入乙醇和盐酸,加热至回流。

将反应瓶置于电热套上,回流反应2小时。

冷却后,将反应液倒入烧杯中,用滤纸过滤,滤液用氢氧化钠中和至中性。

将中和后的溶液倒入烧杯中,加入无水硫酸钠,过滤,滤液用氢氧化钠中和至中性。

3. 精制:将上述滤液倒入烧杯中,加入无水硫酸钠,过滤,滤液用无水碳酸钠中和至中性。

将中和后的溶液倒入烧杯中,加入无水硫酸钠,过滤,滤液用无水碳酸钠中和至中性。

4. 结晶:将上述滤液倒入烧杯中,加入无水硫酸钠,搅拌至结晶。

将结晶用滤纸过滤,滤液用无水碳酸钠中和至中性。

将中和后的溶液倒入烧杯中,加入无水硫酸钠,搅拌至结晶。

将结晶用滤纸过滤,滤液用无水碳酸钠中和至中性。

5. 干燥:将结晶用滤纸过滤,滤液用无水碳酸钠中和至中性。

将中和后的溶液倒入烧杯中,加入无水硫酸钠,搅拌至结晶。

胆碱酯酶(ChE)检测试剂盒(羟胺氯化铁比色法)

胆碱酯酶(ChE)检测试剂盒(羟胺氯化铁比色法)

胆碱酯酶(ChE)检测试剂盒(羟胺氯化铁比色法)简介:胆碱酯酶(cholinesterase,ChE)属于特异性酯酶,可分为两大类。

一类是乙酰胆碱酯酶(Acetyl cholinesterase,EC 3.1.1.7, AChE)又称为真性胆碱酯酶,能水解乙酰胆碱,起到生理的调节作用;另一类为胆碱酯酶,又称假性胆碱酯酶(Pseudo cholinesterase,3.1.1.8,PsChE)或拟胆碱酯酶,能水解胆碱的酯而不能水解乙酰胆碱酯。

乙酰胆碱酯酶主要存在于神经元的胞质内、神经与肌肉接头处即所谓运动终板处;PsChE主要存在于血浆、胰腺、唾液腺内,生理功能尚不明确。

测定胆碱酯酶可以判断有机磷中毒的程度,鉴定遗传性胆碱酯酶变异,肝实质性损害程度。

Leagene胆碱酯酶(ChE)检测试剂盒(羟胺氯化铁比色法)其检测原理是待测样品中的胆碱酯酶能催化乙酰胆碱水解生成胆碱和乙酸。

剩余的乙酰胆碱与羟胺作用生成乙酸羟胺,后者与三价铁离子结合生成呈棕色复合物,通过分光光度计检测吸光度,根据标准曲线即可测出ChE活力。

该试剂盒仅用于科研领域,不宜用于临床诊断或其他用途。

组成:自备材料:1、蒸馏水2、离心管或小试管3、水浴锅4、离心机5、比色杯6、分光光度计操作步骤(仅供参考):编号名称TE021350TStorage试剂(A): ChE buffer Ⅰ16ml 4℃避光试剂(B): ChE buffer Ⅱ2ml 4℃避光试剂(C): ChE buffer Ⅲ2ml RT试剂(D): 羟胺溶液10ml 4℃避光试剂(E): 羟胺缓冲液10ml RT试剂(F): ChE酸化液40ml RT试剂(G): ChE显色液50ml RT 避光使用说明书1份1、准备样品:①血浆、血清样品:血浆、血清按照常规方法制备,可以直接用于本试剂盒的测定,-70℃冻存,用于ChE的检测。

②细胞或组织样品:取恰当细胞或组织进行匀浆,低速离心取上清,-70℃冻存,用于ChE的检测。

SDS增敏荧光光度法测定人血清中左氧氟沙星的残留量

SDS增敏荧光光度法测定人血清中左氧氟沙星的残留量

SDS增敏荧光光度法测定人血清中左氧氟沙星的残留量
董学芝;席会平;胡卫平;李畅;张国胜
【期刊名称】《华西药学杂志》
【年(卷),期】2007(22)4
【摘要】目的建立人血清中左氧氟沙星(LOX)残留量的快速测定方法。

方法采用十二烷基硫酸钠(SDS)增敏荧光光度法。

结果用无水乙醇沉淀蛋白,对血清进行预处理,利用LOX-SDS体系测定,人血清中LOX在0.1~5.0μg.ml-1时,荧光强度与浓度呈线性关系,其回归方程为:F=5.552+40.019C(r=0.9990),平均回收率为
99.72%,RSD=0.68%。

结论所建方法简便、准确、快速,可用于人血清中LOX的测定。

【总页数】3页(P435-437)
【关键词】十二烷基硫酸钠增敏荧光分光光度法;左氧氟沙星;血清;残留量
【作者】董学芝;席会平;胡卫平;李畅;张国胜
【作者单位】河南大学化学化工学院
【正文语种】中文
【中图分类】R917
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2.聚乙二醇辛基苯基醚胶束增敏荧光分光光度法测定人尿中痕量1-羟基芘 [J], 欧
阳运富;王永生;唐宏兵
3.微乳液增敏对硝基苯基荧光酮光度法测定人发中痕量镍 [J], 杜斌;吴丹;魏琴;张慧;欧庆瑜
4.功能性CdS纳米荧光探针荧光增敏法测定人血清白蛋白 [J], 汪乐余;周运友;朱昌青;张明翠;陶海升;王伦
5.新荧光试剂5-(4-羧基苯偶氮)-8-水杨醛缩氨基喹啉荧光增敏法测定人血清蛋白质 [J], 张明翠;汪乐余;李玲;陈红旗;张德兴;王伦
因版权原因,仅展示原文概要,查看原文内容请购买。

羟自由基清除能力检测试剂盒说明书 微量法

羟自由基清除能力检测试剂盒说明书 微量法

北京索莱宝科技有限公司羟自由基清除能力检测试剂盒说明书微量法注意:正式测定前务必取2-3个预期差异较大的样本做预测定。

货号:BC1325规格:100T/96S 产品内容:提取液:液体110mL×1瓶,4℃保存。

试剂一:液体8mL×1瓶,4℃避光保存。

试剂二:液体15mL×1瓶,4℃保存。

试剂三:液体15mL×1瓶,4℃保存。

试剂四:液体0.16mL×1瓶,4℃避光保存。

临用前加入9.84mL 蒸馏水混匀,也可按比例现用现配,配好的试剂4℃保存一周。

产品说明:羟自由基是人体在新陈代谢过程中产生的对生物体毒性强、危害大的一种自由基。

它可以使组织中的糖类、氨基酸、蛋白质、核酸等物质发生氧化,遭受氧化性损伤和破坏,导致细胞坏死或突变。

羟自由基清除能力是样品抗氧化能力的重要指标之一,在抗氧化类保健品和药品研究中得到广泛应用。

H 2O 2/Fe 2+通过Fenton 反应产生羟自由基,将邻二氮菲-Fe 2+水溶液中Fe 2+氧化为Fe 3+,导致536nm 的吸光度下降,样品536nm 吸光度下降速率的抑制程度,反映了样品清除羟自由基的能力。

自备实验用品:恒温水浴锅、可见分光光度计/酶标仪、微量玻璃比色皿/96孔板、低温离心机、研钵/匀浆器和蒸馏水。

操作步骤:一、样品的制备:(1)组织样品的制备:称取约0.1g 组织,加入1mL 提取液进行冰浴匀浆;10000g 4℃离心10min,取上清,置冰上待测。

(2)血清、果汁等液体样品可直接测定。

(3)提取物(或者药物)可配制成一定浓度,如5mg/mL。

二、测定步骤:1、分光光度计或酶标仪预热30min以上,调节波长至536nm,蒸馏水调零。

2、操作表:在1.5或0.5mLEP管中分别加入下列试剂空白管对照管测定管试剂一(µL)505050试剂二(µL)100100100试剂三(µL)100100100充分混匀,防止颜色不均一。

高效液相色谱法测定草酸艾司西酞普兰片的含量

高效液相色谱法测定草酸艾司西酞普兰片的含量

高效液相色谱法测定草酸艾司西酞普兰片的含量代亚;付涛;俞丽君;陈立萍;王贤广【摘要】目的采用高效液相色谱法测定草酸艾司西酞普兰片的含量.方法色谱柱为C18柱(250 mm×4.6 mm,5 μm),流动相为磷酸缓冲液-甲醇(51 ∶49),检测波长为238 nm.结果艾司西酞普兰质量浓度在25 ~150 μg/mL范围内与峰面积呈良好线性关系(r=0.999 9),平均回收率为99.60%,RSD为0.44%.结论该方法简便,专属性及重现性好,可用于测定草酸艾司西酞普兰片的含量.【期刊名称】《中国药业》【年(卷),期】2011(020)016【总页数】2页(P32-33)【关键词】草酸艾司西酞普兰片;含量测定;高效液相色谱法【作者】代亚;付涛;俞丽君;陈立萍;王贤广【作者单位】浙江海森药业有限公司,浙江,杭州,322104;浙江海森药业有限公司,浙江,杭州,322104;浙江海森药业有限公司,浙江,杭州,322104;浙江海森药业有限公司,浙江,杭州,322104;浙江海森药业有限公司,浙江,杭州,322104【正文语种】中文【中图分类】R927.2;R971+.43自从1985年第1个5-羟色胺再吸收抑制剂(SSRIs)上市以来,其在临床得到了广泛应用。

这类药物不产生三环类抗抑郁药的抗副交感神经作用、低血压、认知障碍或镇静等副作用,是一类性能优良的抗抑郁药。

草酸艾司西酞普兰(escitalopram oxalate)就是其中的一种,它是消旋体药物西酞普兰(由 R-西酞普兰和 S-西酞普兰按1∶1的比例组成)的 S-西酞普兰,S-西酞普兰药效优于R-西酞普兰[1]。

该药是由丹麦的Lundbeck公司首先研究开发,2002年8月首次被美国食品与药物管理局(FDA)批准,主要用于重型抑郁障碍的初始治疗和维持治疗。

笔者采用高效液相色谱(HPLC)法测定草酸艾司西酞普兰片的含量,按照2010年版《中国药典(二部)》附录中药品质量标准分析方法验证指导原则[2]进行了方法学试验,现报道如下。

Calcipotriol_SDS_MedChemExpress

Calcipotriol_SDS_MedChemExpress

Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Sep.-13-2017Print Date:Sep.-13-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :CalcipotriolCatalog No. :HY-10001CAS No. :112965-21-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:MC 903; CalcipotrieneFormula:C27H40O3Molecular Weight:412.60CAS No. :112965-21-64. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature: 4°C, protect from light, stored under nitrogenShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

盐酸吡哆醇 液相色谱

盐酸吡哆醇 液相色谱

盐酸吡哆醇液相色谱
盐酸吡哆醇(Hydrochloride Pyridoxine),也称为维生素B6盐酸盐,是一种常见的药物。

液相色谱(Liquid Chromatography,简称LC)是一种常用的分析方法,用于分离和定量化合物混合物中的成分。

液相色谱分析盐酸吡哆醇的方法通常包括以下步骤:
1.样品制备:将待分析的盐酸吡哆醇标准品或样品溶解或稀释
成适宜的浓度,以便进行后续的分析。

2.色谱柱选择:选择适合的色谱柱来保证目标化合物的有效分
离和定量。

常见的列如反相色谱柱(C18柱)或其他合适的类型。

3.移动相准备:制备合适的移动相(溶剂)用于样品的分离。

这可能包括单一溶剂或多组分组合的混合溶剂。

4.进样和分离:将样品注入色谱仪中,并通过色谱柱进行分离。

利用柱内的填料通过溶剂作用,不同成分具有不同的挥发性和亲疏水性会导致它们在柱上以不同的速率移动。

5.检测和测定:使用合适的检测器(例如紫外-可见吸收光谱
仪)对目标化合物进行定量分析。

通过对峰的特征进行测量,如保留时间和峰面积,可以确定盐酸吡哆醇的浓度。

6.数据处理:对测定结果进行处理和分析,计算盐酸吡哆醇的
含量或其它所需的参数。

这是一种简化的液相色谱分析盐酸吡哆醇的一般过程,实际操
作中可以根据需要进行一些调整和优化。

分析师需要熟悉色谱仪的操作和仪器调整,以及相应的分析条件和方法验证要求。

莽草酸脱氢酶(SD)活性检测试剂盒说明书__紫外分光光度法UPLC-MS-4468

莽草酸脱氢酶(SD)活性检测试剂盒说明书__紫外分光光度法UPLC-MS-4468

莽草酸脱氢酶(SD)活性检测试剂盒说明书货号:UPLC-MS-4468规格:50T/48S紫外分光光度法产品组成:使用前请认真核对试剂体积与瓶内体积是否一致,有疑问请及时联系工作人员。

试剂名称规格保存条件提取液液体60mL×1瓶4℃保存试剂一液体20mL×1瓶4℃保存试剂二粉剂×1瓶4℃保存试剂三粉剂×2瓶-20℃保存溶液的配制:1、提取液:内含不溶物,用前摇匀。

2、试剂二:临用前加入10mL蒸馏水溶解。

3、试剂三:临用前每瓶加入11mL蒸馏水溶解。

4、工作液的配制:根据用量按照试剂一:试剂二:试剂三为7:4:8的体积比例充分混匀,现用现配,用前25℃预热15min。

产品说明:莽草酸途径是存在于植物和微生物中的一条重要的代谢途径,莽草酸脱氢酶(EC1.1.1.25)是莽草酸合成代谢途径中催化第四步反应的关键酶。

莽草酸脱氢酶催化莽草酸和NADP产生NADPH,检测340nm下的吸光值增加速率来表示SD活性。

注意:实验之前建议选择2-3个预期差异大的样本做预实验。

如果样本吸光值不在测量范围内建议稀释或者增加样本量进行检测。

需自备的仪器和用品:紫外分光光度计、台式离心机、水浴锅、1mL石英比色皿、可调式移液枪、研钵/匀浆器、冰和蒸馏水。

操作步骤:一、样本处理(可适当调整待测样本量,具体比例可以参考文献)1、组织:按照组织质量(g):提取液体积(mL)为1:5~10的比例(建议称取约0.1g组织,加入1mL提取液(加入前摇匀))进行冰浴匀浆,然后8000g,4℃,离心10min,取上清置于冰上待测。

2、细胞:先收集细菌或细胞到离心管内,离心后弃上清;按照细胞数量(104个):提取液体积(mL)为500~1000:1的比例(建议500万细胞加入1mL提取液),冰浴超声波破碎细胞(功率300w,超声3秒,间隔7秒,总时间3min);然后8000g,4℃,离心10min,取上清置于冰上待测。

圣草酚检测

圣草酚检测

迪信泰检测平台
圣草酚检测
圣草酚(eriodictyol)又称北美圣草素,是广泛分布于水果和蔬菜中的多酚黄酮类化合物,主要存在于柠檬和花生中。

具有抗氧化、抗炎、镇痛、改善糖尿病及糖尿病并发症的作用。

迪信泰检测平台采用高效液相色谱(HPLC)法,结合蒸发光散射检测器(ELSD)或DAD检测器,可高效、精准的检测样本中圣草酚的含量变化。

此外,迪信泰检测平台还提供其他植物黄酮检测服务,以满足您的不同需求。

HPLC测定圣草酚样本要求:
1. 请确保样本量大于0.2g或者0.2mL。

周期:2~3周。

项目结束后迪信泰检测平台将会提供详细中英文双语技术报告,报告包括:
1. 实验步骤(中英文)。

2. 相关质谱参数(中英文)。

3. 质谱图片。

4. 原始数据。

5. 圣草酚含量信息。

迪信泰检测平台可根据需求定制其他物质测定方案,具体可免费咨询技术支持。

氟伐他汀钠

氟伐他汀钠

主要用途
医药原料药
储存条件
干燥时-20°C
谢谢观看
基本信息
中文名称:氟伐他汀钠 中文别名:3R﹡,5S﹡-(E)]-(±)-7-[3-(4-氟苯基)-1-异丙基-1H-吲哚 -2-基]-3,5-二羟基-6-庚烯酸钠 英文名称:FLUVASTATIN SODIUM 英文别名:Sodium(+-)(E)-3,5-dihydroxy-7-[3'-(4”-fluorophenyl)-1'-methylethyl-indol-2'yl]hept-6-enoate CAS NO.:93957-55-2 分子式:C24H25FNNaO4 分子量:433.4478
方法2:间苯三酚经催化氢化得化合物(Ⅳ)。与叔丁基二苯基氯硅烷反应得化合物(V),再氧化为(Ⅵ)。经间 氯过苯甲酸氧化为(Ⅶ),开环得(Ⅷ)。再氧化为(Ⅸ)。(Ⅸ)和中间体x缩合得(Ⅺ),脱保护基再水解,即得氟伐 他汀钠。
中间体(X)可从化合物(I)出发,经甲酰化、还原、氯化,再和三苯膦作用而得 。
物化信息
沸点:681.8°C at 760 mmHg 闪点:366.1°C 熔点 :194-197°C 蒸汽压:1.6E-19mmHg at 25°C 性状:本品为类白色结晶粉末 主要用途:医药原料药
适应症
高血脂症
用途
氯乙酰基)氟苯和N-异丙基苯胺缩合,得化合物(I)。然后在乙腈中,三氯氧磷存在下,和N,N二甲基氨基丙烯醛反应,得化合物(Ⅱ)。化合物(Ⅱ)在强碱作用下,和乙酰乙酸甲酯缩合,再经拆分,得化合物 (Ⅲ)。在-77~-74℃,将化合物(Ⅲ)滴加到硼氢化钠、甲氧基二乙基硼、四氢呋喃和甲醇的混合液中,搅拌 30min;得到的环状硼酸酯在乙酸乙酯中,用30%双氧水处理;再水解得氟伐他汀钠。
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Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :ChloramphenicolCatalog No. :HY-B0239CAS No. :56-75-71.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:C11H12Cl2N2O5Molecular Weight:323.13CAS No. :56-75-74. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

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