Yoon-2007-Increased beta-carot

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培唑帕尼在肿瘤临床治疗应用的研究进展

培唑帕尼在肿瘤临床治疗应用的研究进展

analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets[J]. Nat Genet ,2017,49:416-425.
essential for elastogenesis in vivo[J]. Nature,2002,415:171-175.
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橙皮苷对DOCA

橙皮苷对DOCA

网络出版时间:2023-08-3014:39:20 网络出版地址:https://link.cnki.net/urlid/34.1086.R.20230830.1153.002橙皮苷对DOCA/Salt高血压大鼠心肾组织损害的保护作用杨 彬1,陈 哲2,全虹翰1,高海英1,朱 青1(1.广东药科大学中医药研究院,2.广州中医药大学科技创新中心,广东广州 510006)收稿日期:2023-03-10,修回日期:2023-06-20基金项目:国家自然科学基金资助项目(No81770707)作者简介:杨 彬(1996-),女,硕士,研究方向:高血压及肾脏疾病的中医药防治,E mail:young9612@163.com;朱 青(1980-),男,博士,教授,硕士生导师,研究方向:高血压及肾脏药理学,通信作者,E mail:zyq973@hotmail.comdoi:10.12360/CPB202208041文献标志码:A文章编号:1001-1978(2023)09-1705-06中国图书分类号:R 332;R284 1;R322 11;R322 61;R364 5;R544 1摘要:目的 探讨橙皮苷(hesperidin,HES)对高血压大鼠心肾损害的保护作用及可能机制。

方法 雄性SD大鼠18只随机分为3组:对照组(Ctrl)、高血压模型组(DOCA/Salt)、橙皮苷给药组(DOCA/Salt+HES)。

HES持续给药4周,检测血压、血清肌酐、尿素氮等指标,HE、马松和天狼星红染色观察心、肾组织病理改变,Westernblot检测α SMA、collagenⅠ和TGF β等蛋白表达,qRT PCR分别检测Nlrp3、TNF α、IL 1β、IL 6和NOXs的mRNA表达。

结果 与模型组比较,HES给药明显减缓DOCA/Salt高血压的发生,改善高血压大鼠肾功能指标,减少肾脏和心脏组织纤维化,降低α SMA、collagenⅠ和TGF β的表达,抑制Nlrp3,TNF α、IL 1β和IL 6等炎症因子释放,减少肾脏和心脏组织中NOXs表达。

FILM FORMED BY SECONDARILY GROWING SEED CRYSTALS H

FILM FORMED BY SECONDARILY GROWING SEED CRYSTALS H

专利名称:FILM FORMED BY SECONDARILY GROWING SEED CRYSTALS HAVING THREE CRYSTALAXES ORIENTED ON A SUBSTRATE发明人:YOON, Kyung Byung,윤경병,PHAM,CaoThanhTung,팜카오탄툼申请号:KR2011/006629申请日:20110907公开号:WO2012/033347A2公开日:20120315专利内容由知识产权出版社提供专利附图:摘要:The present invention relates to a method for preparing a thin or thick film, andto a film prepared by same, the method comprising: a first step of obtaining non-spherical seed crystals, the respective crystal axes of which, i.e. an a-axis, b-axis and c-axis, are all oriented on a substrate according to certain rules; and a second step of forming and growing a film from the seed crystals using a secondary growth technique by exposing the seed crystals, the a-axis, b-axis, and c-axis of which are all crystal-oriented, to a seed-crystal growing solution. According to the present invention, it is possible to prepare crystals or films larger than the seed crystals.申请人:INDUSTRY-UNIVERSITY COOPERATION FOUNDATION SOGANG UNIVERSITY,서강대학교산학협력단,YOON, Kyung Byung,윤경병,PHAM, CaoThanhTung,팜카오탄툼地址:1-1, Sinsu-dong, Mapo-gu, Seoul 121-742 KR,서울특별시마포구신수동 1-1, 121-742 Seoul KR,345-123, Pyeongchang-dong, Jongno-gu, Seoul 110-847 KR,서울특별시종로구평창동 345-123, 110-847 Seoul KR,6F, Sogang Bldg., Sinsu-dong, Mapo-gu, Seoul 121-854 KR,서울특별시마포구신수동서강빌딩 6층, 121-854 Seoul KR国籍:KR,KR,KR,KR,KR,KR代理人:SON, Min,손민更多信息请下载全文后查看。

基于主成分分析的糯玉米杂交组合农艺性状综合评价

基于主成分分析的糯玉米杂交组合农艺性状综合评价

山西农业科学2022,50(7):938-944Journal of Shanxi Agricultural Sciences基于主成分分析的糯玉米杂交组合农艺性状综合评价王俊花,邵林生,闫建宾,王瑞钢,张雪彪,庞旭,张沛敏(山西农业大学高粱研究所,山西晋中030600)摘要:为了从玉米大量的农艺性状中筛选出用于可综合评价的主要性状,以提高糯玉米育种效率,以甜糯182号为对照,对60份鲜食糯玉米杂交组合的9个农艺性状进行遗传变异、相关性和主成分分析。

结果表明,各农艺性状的变异系数在5.03%~72.03%,其中,秃尖长变异系数最大,生育期变异系数最小。

相关性分析表明,单穗鲜质量与穗粗、穗行数、行粒数、穗长、株高呈极显著正相关,作用效应大小为穗粗>穗行数>行粒数>穗长>株高;秃尖长与单穗鲜质量、穗粗、行粒数呈极显著负相关;穗部各性状之间关联较大,穗长与穗粗和行粒数、穗粗与穗行数和行粒数、穗行数与行粒数都呈极显著正相关;穗长与穗行数呈显著正相关。

主成分分析结果表明,前5个主成分累计贡献率达87.629%,第1主成分为产量因子,是糯玉米杂交组合评判的主要指标;第2主成分为穗位高因子;第3主成分为秃尖长因子;第4主成分为生育期因子;第5主成分为穗长因子。

基于主成分分析的综合评价结果,结合鲜食糯玉米果穗等级划分标准,筛选出18份优良的糯玉米杂交组合,分别为J27、J61、J7、J16、J4、J14、J5、J32、J12、J13、J39、J44、J1、J60、J23、J28、J10、J24。

综上可见,在山西省晋中盆地糯玉米高产优质育种中,要注重对单穗鲜质量大、穗长较长、秃尖较短、生育期87d 左右的杂交组合进行选择。

关键词:糯玉米;杂交组合;综合评价;相关分析;主成分分析中图分类号:S513文献标识码:A文章编号:1002‒2481(2022)07‒0938‒07Comprehensive Evaluation of Agronomic Traits Based on PrincipalComponent Analysis of Waxy Cross CombinationsWANG Junhua ,SHAO Linsheng ,YAN Jianbin ,WANG Ruigang ,ZHANG Xuebiao ,PANG Xu ,ZHANG Peimin(Institute of Sorghum ,Shanxi Agricultural University ,Jinzhong 030600,China )Abstract :To select main traits used on comprehensive evaluation from a large number of agronomic traits of maize for improving breeding efficiency of waxy maize,Tiannuo 182was used as the control,genetic variation,correlation,and principal component analysis of nine agronomic traits of 60fresh waxy maize cross combinations were analyzed in this study.The results showed that the variation coefficient of agronomic traits was 5.03%-72.03%,the variation coefficient of bald tip length was the largest and that of growth period was the smallest.The correlation analysis indicated that single ear fresh weight was extremely significantly positively correlated with ear diameter,ear row number,row grain number,ear length,and plant height.The effect was as follows:ear diameter >ear row number >row grain number >ear length >plant height.The bald tip length had a extremely significant negative correlation with single ear fresh weight,ear diameter,and row grain number.The traits of ear had association,there was a extremely significant positive correlation between ear length,ear diameter and row grain number,between ear diameter,ear row number and row grain number,and between ear row number and row grain number.There was a significant positive correlation between ear length and ear row number.Principal component analysis showed the accumulative contribution rates of the first 5principal components reached to 87.629%.The first principal component was yield factor,it was the main index of waxy corn hybrid combination evaluation.The second,third,fourth and fifth principal component was ear height factor,bald tip length factor,growth period factor,and ear length factor respectively.Based on comprehensive evaluation with principal component analysis and fruit ear grading standards of fresh edible waxy corn,18excellent cross combinations of waxy maize were screened out,including J27,J61,J7,J16,J4,J14,J5,J32,J12,J13,J39,J44,J1,J60,J23,J28,J10,J24.In conclusion,selection of cross combinations with large single ear yield,longer ear length,shorter bald tip length,87d growth period should be emphasized in the breeding for high yield and excellent quality waxy maize in Jinzhong Basin of Shanxi.Key words :waxy maize;cross combinations;comprehensive evaluation;correlation analysis;principal component analysisdoidoi:10.3969/j.issn.1002-2481.2022.07.03收稿日期:2021-08-16基金项目:山西农业大学生物育种工程项目(YZGC057)作者简介:王俊花(1973-),女,山西垣曲人,副研究员,硕士,主要从事鲜食玉米遗传育种研究工作。

山药块茎膨大期淀粉积累及淀粉合成相关基因表达分析

山药块茎膨大期淀粉积累及淀粉合成相关基因表达分析

中国瓜菜2023,36(3):69-76山药(Dioscorea opposita Thunb.)是薯蓣科(Dioscoreaceae)薯蓣属(Dioscorea L.)一年生或多年生缠绕性草质藤本,为单子叶植物[1]。

山药块茎中含有丰富的淀粉(70%)、蛋白质(9%)、还富含矿物质、尿囊素、皂苷等活性物质,并且与其他作物如马铃薯、木薯和甘薯相比,山药有着更好的感官特性,因此,近年来对山药的需求量逐年增多[2]。

淀粉是山药块茎中最丰富的碳水化合物,含量约占块茎干质量的80%左右。

淀粉积累不仅影响块茎膨大,对山药直接经济效益的产生和品质形成山药块茎膨大期淀粉积累及淀粉合成相关基因表达分析索宁宁,张艳芳,高圆丽,赵令敏,葛明然,刘杰才,霍秀文(内蒙古农业大学园艺与植物保护学院呼和浩特010019)摘要:为探讨山药块茎膨大期淀粉的积累机制,以大和长芋山药为试验材料,测定了块茎膨大期各类淀粉含量、淀粉合成关键酶活性以及淀粉合成相关基因的表达水平。

结果表明,山药块茎膨大期总淀粉、直链淀粉及支链淀粉的积累呈先增加后降低的趋势,种植后150d支链淀粉占总淀粉含量的88.35%,总淀粉含量的增加主要是支链淀粉的积累;ADP-葡萄糖焦磷酸化酶(AGPase)、淀粉分支酶(SBE)与支链淀粉的积累呈极显著正相关,是直接参与支链淀粉积累的重要功能酶。

AGPase、SSⅡ、SSⅢ、SBEⅡ基因的表达量与支链淀粉含量呈极显著正相关,是支链淀粉积累的关键因素。

SBE对淀粉积累表现为直接正效应,AGPase和束缚态淀粉合成酶(GBSS)在直链淀粉积累中体现为直接正效应。

这些研究对揭示山药块茎淀粉合成的分子机制具有重要意义。

关键词:山药块茎;淀粉积累;淀粉合成关键酶;基因表达中图分类号:S632.1文献标志码:A文章编号:1673-2871(2023)03-069-08Analysis of starch accumulation and starch synthesis-related gene expres-sion during tuber expansion stage of yamSUO Ningning,ZHANG Yanfang,GAO Yuanli,ZHAO Lingmin,GE Mingran,LIU Jiecai,HUO Xiuwen(College of Horticulture and Plant Protection,Inner Mongolia Agricultural University,Hohhot010019,Inner Mongolia,China)Abstract:In order to explore the accumulation mechanism of starch during the expansion stage in yam tubers,we investi-gated the changes in starch content of various types,activity of key enzymes in starch synthesis and gene expression pat-terns of starch synthesis key enzymes in Dahechangyu yam tubers.The results showed that the accumulation of total starch,amylose and amylopectin showed a trend of increasing first and then decreasing during tuber expansion stage of yam,and amylopectin accounts for88.35%of the total starch content150days after planting.The increase of total starch content mainly results from amylopectin accumulation.Glucose-1-phosphate adenylyltransferase(AGPase)and starch-branching enzyme(SBE)have significant positive correlation with the accumulation of amylopectin,and are impor-tant functional enzymes directly involved in the accumulation of amylopectin.The gene expression level of AGPase,SSII, SSIII,SBEII was positively correlated with amylopectin content,which was the key factor of amylopectin accumulation inyam tubers.SBE showed a directly positive effect on starch accumulation,AGPase and granule bound starch synthase have directly positive effect on amylose accumulation.These studies are of great significance to reveal the molecular mechanism of starch synthesis in yam tubers.Key words:Yam tuber;Starch accumulation;Starch synthesis key enzyme;Gene expression收稿日期:2022-11-01;修回日期:2023-01-31基金项目:国家自然科学基金(31860558);内蒙古自治区科技计划项目(2020GG0044)作者简介:索宁宁,男,在读硕士研究生,主要从事蔬菜种质资源与生物技术研究。

韩国射手座女明星有哪些

韩国射手座女明星有哪些

韩国射手座女明星有哪些射手风风火火的性格虽然没少得罪人,但也赢得不少可以肝胆相照的朋友!那么你知道韩国射手座女明星有哪些?下面店铺告诉你韩国射手座女明星,欢迎阅读。

韩国射手座女明星——咸慇晶外文名:함은정、HamEunJung别名:白球、女王、睡恩静、小白国籍:韩国民族:朝鲜族星座:射手座血型:O型身高:168cm体重:46kg出生地:韩国出生日期:1988年12月12日职业:歌手、演员毕业院校:韩国东国大学表演艺术学院经纪公司:CoreCentensMedia代表作品:单曲《Bopeepbopeep》、《Lovey-Dovey》,电影《White》主要成就2010首尔歌谣大赏新人奖2010年SBS演技大赏新人赏2011年MBC演艺大赏女子新人奖所属组合:T-ara、T-araN4队内职务:Rapper、主唱、领舞咸恩静即咸慇晶。

咸慇晶,出生于1988年12月12日,韩国女歌手、演员,韩国女子组合T-ara第一任队长,队内的帅气担当,职务是Rapper、领舞、主唱。

2009年以组合T-ara出道,2011年,与李章宇共同出演MBC综艺节目《我们结婚了》。

其所属组合荣获韩国2011年年度音源销量冠军、首尔歌谣大赏音源赏、金唱片大赏音源赏等,成为韩国K-pop界领军人物之一。

2013年发表全新专辑《Again》及后续曲《我怎么办》、《捉迷藏》等。

韩国射手座女明星——李侑菲外文名:LeeYuBi,이유비别名:李侑真国籍:韩国出生地:首尔市出生日期:1990年11月22日职业:演员毕业院校:梨花女子大学声乐系经纪公司:sidusHQ代表作品:《吸血鬼偶像》、《善良的男人》、《九家之书》李侑菲(LeeYuFei),是韩国sidusHQ公司艺人,就读于梨花女子大学声乐系。

2011年通过MBN情景喜剧《吸血鬼偶像》正式出道。

2012年在大热的KBS水木剧《善良的男人》中饰演姜巧可,2013年MBC月火剧《九家之书》中饰演朴清照。

原发性胆囊癌的早期诊断

原发性胆囊癌的早期诊断

原发性胆囊癌的早期诊断殷保兵【摘要】原发性胆囊癌是胆道常见恶性肿瘤,恶性程度高,发现时往往伴有肝脏转移,预后极差。

掌握原发性胆囊癌的高危因素,对胆囊癌高危人群进行密切随访和筛选,可提高原发性胆囊癌的早期诊断率,对改善胆囊癌的预后有重大意义。

%Primary gallbladder carcinoma (PGC) is the common malignant tumour in biliary tract and is associated with poor prognosis in patients with liver metastasis. It is important to understand the high risk factors of PGC, and closely follow up and screen the high-risk populations in order to improve the early diagnosis of gallbladder cancer and its prognosis.【期刊名称】《上海医药》【年(卷),期】2014(000)014【总页数】3页(P12-14)【关键词】胆囊癌;早期诊断;高危人群【作者】殷保兵【作者单位】复旦大学附属华山医院外科上海 200040【正文语种】中文【中图分类】R735.8原发性胆囊癌是最常见的胆道恶性肿瘤,约占消化道恶性肿瘤的第6位[1-2]。

2007年上海市胆囊癌发病率男性为5.90/10万,女性为10.22/10万,而同期全国胆囊癌死亡率高达4.07/10万[3-4]。

邹声泉等[5]报道2000年我国大陆原发性胆囊癌发病率占同期胆道疾病的0.4%~3.8%。

近年来,胆囊癌的发病率有上升趋势,而发病年龄则呈下降趋势。

胆囊癌的早期诊断非常困难,而其恶性程度极高,且易转移复发,因此预后极差,进展期胆囊癌的中位生存期仅6个月,5年生存率仅为5%[2]。

不同杀虫剂对草地贪夜蛾的室内毒杀效果研究

不同杀虫剂对草地贪夜蛾的室内毒杀效果研究

不同杀虫剂对草地贪夜蛾的室内毒杀效果研究杨云1金容1夏清清1符鹏1杨凯2龙芸3*(1南充市农业科学院,四川南充637000;2射洪市职业中专学校,四川射洪629200;3西华师范大学,四川南充637000)摘要为探索不同药剂对玉米草地贪夜蛾的室内毒杀效果,本试验采用浸叶法喂食3龄草地贪夜蛾带有6种药剂的叶片,分析48h 后各药剂对草地贪夜蛾的毒力测定结果和草地贪夜蛾在不同时间段的校正死亡率。

结果表明,药剂处理48h 后,6种药剂毒力强弱排序为35%氯虫苯甲酰胺>10亿PIB/mL 斜纹夜蛾核型多角体病毒>10%阿维菌素·除虫脲>10%溴氰虫酰胺>6%联苯菊酯·啶虫脒>2%阿维菌素·高效氯氰菊酯。

10亿PIB/mL 斜纹夜蛾核型多角体病毒悬浮剂1000mg/L 处理24h 后校正死亡率为83.33%,72h 后校正死亡率为100.00%;35%氯虫苯甲酰胺水分散粒剂100mg/L 处理24h 后草地贪夜蛾校正死亡率为6.67%,其他药剂处理24h 后草地贪夜蛾校正死亡率均为0%。

关键词草地贪夜蛾;杀虫剂;毒力;校正死亡率中图分类号S433.4;S482.3文献标识码A文章编号1007-5739(2023)23-0107-04DOI :10.3969/j.issn.1007-5739.2023.23.028开放科学(资源服务)标识码(OSID ):Indoor Toxicity Effects of Different Insecticides Against Spodoptera frugiperdaYANG Yun 1JIN Rong 1XIA Qingqing 1FU Peng 1YANG Kai 2LONG Yun 3*(1Nanchong Academy of Agricultural Sciences,Nanchong Sichuan 637000;2Shehong City Vocational School,Shehong Sichuan 629200;3China West Normal University,Nanchong Sichuan 637000)Abstract In order to explore the indoor toxicity effects of different insesticides against Spodoptera frugiperda ,thisexperiment used the leaf soaking method to feed 3-year-old armyworm leaves with six insesticides.The toxicity effects of each insesticide against Spodoptera litura after 48h and the corrected mortality rate of the armyworm at different time periods were analyzed.The results showed that after 48h of treatment,the order of toxicity of the six insecticides was35%chlorantraniliprole>1billion PIB/mL Spodoptera litura nuclear polyhedrosis virus>10%abamectin ·difenuron>10%cyananthramide>6%bifenthrin ·acetamiprid>2%abamectin ·beta-cypermethrin.After 24h of treatment,the cor-rected mortality rate of Spodoptera frugiperda treated with 1billion PIB/ml Spodoptera litura nuclear polyhedrosis virus SC 1000mg/L was 83.33%;after 72h of treatment,the corrected mortality rate of Spodoptera frugiperda was 100.00%.After 24h of treatment,the corrected mortality rate of Spodoptera frugiperda treated with 35%chlorantraniliprole WG 100mg/L was 6.67%,the corrected mortality rate of Spodoptera frugiperda treated with other insecticides were all 0%.KeywordsSpodoptera frugiperda ;insecticide;toxicity;corrected mortality rate草地贪夜蛾是一种来源于美洲热带和亚热带地区的杂食性害虫,主要为害玉米、水稻、高粱等近80种作物[1]。

金黄色葡萄球菌超抗原肠毒素临床应用研究进展

金黄色葡萄球菌超抗原肠毒素临床应用研究进展

金黄色葡萄球菌超抗原肠毒素临床应用研究进展胡风庆;彭雪【摘要】金黄色葡萄球菌肠毒素(staphylococcal enterotoxins,SEs)是由金黄色萄萄球菌产生的一类典型超抗原(Superantigen,SAg).与传统抗原不同,超抗原无须经抗原提呈细胞(Antigen presenting cell,APC)加工处理,可直接与主要组织相容性复合体Ⅱ类分子(Major histocompatibility complex classⅡmolecules,MHC Ⅱ)及T细胞受体Vβ区(Variable pacts of the T cells receptor,TCR Vβ)特异性结合,极低浓度即可刺激大量T细胞增殖,产生大量有生物学活性的细胞因子(如TNF-α、TNF-β、IFN-γ、IL-2等)和抗肿瘤效应.本文综述了近年来超抗原金葡球菌肠毒素在恶性肿瘤的临床应用、存在问题和解决策略等的进展,针对Trousseau综合征利用超抗原开发新药进行了展望,并介绍了SEC2在临床用于骨病治疗的情况.【期刊名称】《微生物学杂志》【年(卷),期】2016(036)005【总页数】8页(P1-8)【关键词】超抗原;肠毒素;恶性肿瘤;Trousseau综合征【作者】胡风庆;彭雪【作者单位】辽宁大学轻型产业学院,辽宁沈阳110036;辽宁大学轻型产业学院,辽宁沈阳110036【正文语种】中文【中图分类】Q939.9超抗原(Superantigen, SAg)是一些细菌的外毒素或逆转录病毒的产物,是一类具有多种免疫活性的蛋白分子[1]。

根据来源,分为细菌性、病毒性、支原体性和寄生虫性SAg[2-3];根据与宿主关系,分为外源性和内源性SAg,外源性SAg是某些细菌毒素,主要源于金黄色葡萄球菌(Staphylococcus aureus,简称金葡球菌)和链球菌(Streptococcus pyogenes),内源性SAg如鼠类乳腺肿瘤病毒的MLs-1;根据作用细胞类型,分为T细胞和B细胞SAg。

液质联用测定潮汕猪肉丸中的β-受体激动剂

液质联用测定潮汕猪肉丸中的β-受体激动剂
a n a l y z e d b y L C- MS / MS. T h e s a mp l e wa s h y d r o l y z e d b y 一 g l u c u r o n i c a c i d e n z y me, e x t r a c t e d b y a mmo n i u m
r a n g e d f r o m 0 . 2 2% t o 1 . 3 3% . I n t h i s p a p e r , o pt i mi z e d t h e c o n d i t i o n o f L C- MS / MS, t h e me t h o d h a s t h e
l 1 0 . 1 %, 试验的 R S D为 0 . 2 6% 0 . 9 3 %; 莱克 多 巴胺 为 9 0 . 1 %~ 1 0 1 _ 3 %, 试验 的 R S D为 O . 2 2%一 1 . 3 3%。 该 方 法优 化 了
盐 酸 克伦 特 罗和 莱克 多 巴胺 的仪 器分 析 条 件 , 操 作 方便 , 重现 性 好 , 回 收率 高 , 结果 准确 , 能 满足 食 品 安 全控 制 的 检 测
XI E Ho n g,L I Ti n g, YANG Ze —c h u a n
( F o o d Q u a n t i t y S u p e r v i s i o n a n d I n s p e c t i o n s t a t i o n o f G u a n g d o n g ( C h a o z h o u ) , C h a o z h o u 5 2 1 0 1 1 , G u a n g d o n g ,
需要 。
关键 词 : 液 质 联 用仪 ; 潮 汕猪 肉丸 ; 3 - 受体激动剂 ; 盐 酸 克 伦特 罗 ; 莱克 多巴胺

雌二醇对人血管平滑肌细胞合成胶原的抑制作用观察

雌二醇对人血管平滑肌细胞合成胶原的抑制作用观察

雌二醇对人血管平滑肌细胞合成胶原的抑制作用观察
李飞飞;刘秋慧;李莉;刘瑞云
【期刊名称】《中国误诊学杂志》
【年(卷),期】2007(7)5
【总页数】2页(P978-979)
【关键词】雌二醇/药理学;胶原/生物合成;肌;平滑;血管/代谢
【作者】李飞飞;刘秋慧;李莉;刘瑞云
【作者单位】郑州大学第一附属医院急诊科
【正文语种】中文
【中图分类】R543.3
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2.γ—干扰素对人角膜基质细胞I,Ⅱ型胶原合成的抑制作用 [J], 孙兴才;吴静安
3.左旋精氨酸抑制人血管平滑肌细胞合成胶原的作用 [J], 李飞飞;党瑜华;刘瑞云
4.网膜素改善氧化应激对人动脉血管平滑肌细胞Ⅰ、Ⅳ型胶原表达的抑制作用 [J], 郑辉;刘慧娟;葛焕琦;张春风;胡睿;李雪粉
5.槲皮素及异鼠李素对人血管平滑肌细胞胶原合成的影响 [J], 陈维;章茂顺;胡春玲;唐丽萍;张建军
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Adsee611-阿克苏诺贝尔新一代胺基技术增效剂

Adsee611-阿克苏诺贝尔新一代胺基技术增效剂

Adsee® 611: 阿克苏诺贝尔新一代胺基技术增效剂The next-generation amine technology adjuvant fortankside and in-can crop protection applications新一代胺基技术增效剂,适用于桶混和配方作物保护应用2014海利尔农药论坛(第十四届山东省农药信息交流会)暨丰县百农思达(第七届)农药加工技术培训班1.Adsee 611 is AkzoNobel’s next generation adjuvant based on an‘eco-premium’ technology Adsee 611是 AkzoNobel新一代环保增效剂2.Adsee 611 is AkzoNobel’s next generation adjuvant based on an‘eco-premium’ technology优化的脂肪胺聚合物和季铵盐混合物3.Developed to formulate in-can or tank-mix for highly efficientcrop protection formulations 适于高效植保配方应用和桶混应用4.Effective with herbicide, fungicide and insecticide applications适用于除草剂、杀菌剂、杀虫剂配方增效应用Bio-efficacy trials 生物药效测试Tricyclazole三环唑75% WP on rice blast用于稻瘟病Pyricularia oryzae稻瘟病Treatment LC50 (mg/L) LC50 reduction Tricyclazole (单独)三环唑 24.1 naAdsee 611 (0.1% v/v) 16.6 31% Azoxystrobin 嘧菌酯25% SC on rice sheath blight 用于稻纹枯病Rhizoctonia solani稻纹枯病Treatment LC50 (mg/L) LC50 reduction Azoxystrobin (单独)嘧菌酯 26.4 naAdsee 611 (0.1% v/v) 18.5 30%Insecticide Studies - Glasshouse 杀虫剂温室实验Pymetrozine吡蚜酮25% WP on brown plant hopperNilaparvata lugens稻飞虱Treatment LC90 (mg/L) LC90 reduction Pymetrozine (单独)吡蚜酮 232.2 na Adsee 611 (0.1% v/v) 142.3 38% Abamectin阿维菌素1.8% EC on rice leaf roller卷叶蛾Cnaphalocrocis medinalisTreatment LC90 (mg/L) LC90 reduction Abamectin (单独)阿维 0.124 na Adsee 611 (0.1% v/v) 0.096 22.6%用于稻飞虱杀虫剂田间实验Pymetrozine 吡蚜酮25% WP on brown plant hopperNilaparvata lugens 稻飞虱Treatment % Control 14 DAT Pymetrozine (alone 单独吡蚜酮) 68.1 Adsee 611 (0.1% v/v)74.1Abamectin 阿维菌素5% EC on rice leaf rollerCnaphalocrocis medinalis 卷叶蛾Treatment % Control 8 DAT Abamectin (alone 单独阿维) 46.0Adsee 611 (0.1% v/v) 69.8药效提高9%药效提高+50%•Bispyribac-Na on Barnyardgrass 双草醚钠用于稗草The Bispyribac-sodium herbicidal activity treatments on Barnyardgrass has obvious adjuvant synergies 通过添加ADSEE 611,双草醚钠用于稗草上具有明显的增效效果0.10.20.30.40.50.60.70.80.90.100.0.005.0010.0015.0020.0025.0030.0035.00Adsee 625NO AdjuvantAdsee 525Percent weed control (fresh wt basis) at 20DATvs. g ai/ha (adjuvant at 0.1% v/v)Adsee 611•(Leptochloa chinensis 千金子) Sprangletop rate response•100 g/l EC & 0.1% v/v adjuvant 助剂•20 DAT 处理天数% control-20020*********0246810Adsee 611No Adjuvantg ai/haField study – Cyhalofop on grass weeds 氰氟草酯田间除草实验•商业化产品”对比含有20%Adsee 611的10%EC阿克苏实验室样品•Applications were calculated to deliver same amount of ai foreach formulation; per rate每种配方含等量的活性物•Foliar damage evaluated 叶面损害评价at 1, 2, 3 & 4 WAT•Weed species草种类:ECHCG –Echinochloa crus-galli (barnyardgrass稗草)BRAPP –Brachiaria platyphylla (broadleaf signalgrass宽叶臂形草)SORHA –Sorghum halapense (rhizome johnsongrass空心莲子草)Lot NoFormulation Ag0043-12A B C D E F组份wt% wt% wt% wt% wt% wt%氰氟草酯 TC, 97% 10.3 10.3 15.5 15.5 20.6 20.6 Berol 9968 乳化剂5~7 5~7 5~7 5~7 5~7 5~7 Adsee 611 增效剂 5 10 5 10 5 10 Solvesso 150 溶剂To 100 To 100 To 100 To 100 To 100 To 100 测试项目外观透明液体透明液体透明液体透明液体透明液体透明液体储存@ 0±2℃, 7天透明液体透明液体透明液体透明液体透明液体透明液体储存@ 54±2℃,14天透明液体透明液体透明液体透明液体透明液体透明液体1:20 稀释于 342ppm 标准硬水@ 30℃,24hr : 沉淀/析油/油膏热储前0 0 0 0 0.5ml 油膏0.5ml 油膏热储后0 0 0 0 0.5ml 油膏1ml 油膏1:20 乳化稳定性于342ppm 标准硬水@30℃, 24hrs, 热储前后10% Cyhalofop-Butyl EC with 20% Adsee 611Composition组成wt%Cyhalofop-Butyl TC氰氟草酯原药,97% 10.3Berol 9968乳化剂5~7Adsee 611增效剂20Solvesso 150溶剂To 100Test Items 测试项目Appeance@RT 常温外观Clear 透明液体Storage储存@0±2C,7D Clear 透明液体@54±2C,14D Clear 透明液体Emulsion stability乳化稳定性@30C, 1:20稀释于342ppm硬水,24小时Before HAT热储前1ml Cr 油膏After HAT热储后1ml Cr 油膏乳化稳定性,1:20稀释在342ppm硬水@30C,24小时15% Cyhalofop-Butyl EC with 20% Adsee 611Composition组成wt%Cyhalofop-Butyl TC氰氟草酯原药,97% 15.5Berol 9968乳化剂5~7Adsee 611增效剂20Solvesso 150溶剂To 100Test Items 测试项目Appeance@RT 常温外观Clear 透明液体Storage储存@0±2C,7D Clear 透明液体@54±2C,14D Clear 透明液体Emulsion stability乳化稳定性@30C, 1:20稀释于342ppm硬水,24小时Before HAT热储前1ml Cr 油膏After HAT热储后1ml Cr 油膏乳化稳定性,1:20稀释在342ppm硬水@30C,24小时SEM look at short term adjuvant contact 短期接触增效剂后扫描电镜结果•Tested on barnyardgrass and mugwort测试草类为稗草和艾蒿•Test solutions测试方法:•Punched hole in specimen, then 1µl test solution wasapplied to right of hole样本上打一小洞,滴加1µl待测溶液在洞上• 2 hour rest interval before examination2小时后检查•No visible effect on the barnyardgrass稗草上无明显痕迹•Some droplet boundary effects noted on mugwort艾蒿上液滴的边界痕迹被标出Zeiss EVO 50 XVP- SE, VPSE, and BSD detectors- PGT IMIX x-ray microprobe system- Peltier cooling stageImaging non-conductors without coating. Chamber atmosphere control.Mugwort艾蒿;**************%v/v •Note zone of treated surface disruption标记处理的表面破坏区域•Cell surfaces have lost their plumpappearance to become a bit moreskeletonized细胞表面失去饱满外形Adsee 611 is a new option to replace NPE’s or alcohol ethoxylate adjuvants; in-can or tanksideAdsee 611作为新型增效剂以替代壬基酚类或乙氧基化醇类助剂,既可以用在配方中,也可以用于桶混•Useful in-can and tankside用于配方或桶混•Potential replacement for NP-10替代NP-10•Useful across multiple crops and pests用于多种作物和害虫Adsee 611,丰富你的配方工具箱Get a sample of Adsee 611 for your formulation tool box.。

依达拉奉右莰醇注射液对急性大动脉粥样硬化型脑梗死患者炎症反应及不良反应的影响

依达拉奉右莰醇注射液对急性大动脉粥样硬化型脑梗死患者炎症反应及不良反应的影响

DOI:10.19368/ki.2096-1782.2023.07.113依达拉奉右莰醇注射液对急性大动脉粥样硬化型脑梗死患者炎症反应及不良反应的影响冯学才山东省聊城市肿瘤医院内科,山东聊城252000[摘要]目的探讨依达拉奉右莰醇注射液用于急性大动脉粥样硬化型脑梗死患者治疗中的临床效果。

方法选取2021年8月—2022年8月聊城市肿瘤医院收治的92例急性大动脉粥样硬化型脑梗死患者为研究对象,基于“简单随机化方法”规范化分组处理,划分为对照组(实行脑梗死常规治疗)与观察组(实行脑梗死常规治疗+依达拉奉右莰醇注射液治疗),每组46例;观察对比两组临床疗效及不良反应发生率、神经功能缺损及预后情况、血清炎症因子和氧化应激水平。

结果观察组治疗总有效率为95.65%,显著高于对照组的82.61%,差异有统计学意义(χ2=4.039,P<0.05)。

两组不良反应发生率比较,差异无统计学意义(P>0.05)。

治疗3个月后,观察组NIHSS、mRS评分较对照组更低,差异有统计学意义(P<0.05)。

治疗后,两组hs-CRP、MMP-9、MDA水平均下降,SOD水平均升高,其中观察组更优,差异有统计学意义(P<0.05)。

结论急性大动脉粥样硬化型脑梗死患者应用依达拉奉右莰醇注射液,可抑制机体炎症反应及氧化应激反应,改善脑部血供,促进神经功能恢复,提高预后,其治疗安全性及有效性兼顾。

[关键词]依达拉奉右莰醇注射液;大动脉粥样硬化型;脑梗死;炎症反应;不良反应[中图分类号]R742 [文献标识码]A [文章编号]2096-1782(2023)04(a)-0113-05Effects of Edaravone Dextran Injection on Inflammatory Response and Ad⁃verse Reactions in Patients with Acute Large Artery Atherosclerotic Cere⁃bral InfarctionFENG XuecaiDepartment of Internal Medicine, Liaocheng Cancer Hospital, Liaocheng, Shandong Province, 252000 China[Abstract] Objective To investigate the clinical effects of edaravone dextran injection in the treatment of patients with acute large artery atherosclerotic cerebral infarction. Methods 92 patients with acute cerebral infarction of Ath⁃erosclerosis type admitted to Liaocheng Cancer Hospital from August 2021 to August 2022 were selected as the re⁃search objects. Based on the standardized grouping treatment of "simple randomization method", they were divided into a control group (routine treatment of cerebral infarction) and an observation group (routine treatment of cerebral infarction+Edaravone and right camphor injection), with 46 cases in each group. The clinical efficacy and rate of ad⁃verse reactions, neurological deficits and prognosis, serum inflammatory factors and oxidative stress levels were ob⁃served and compared between the two groups. Results The total effective rate of treatment in the observation group was 95.65%, which was statistically significantly higher than that of 82.61% in the control group, and the difference was statistically significant (χ2=4.039, P<0.05). There was no statistically significant difference in the rate of adverse reactions between the two groups (P>0.05). After 3 months of treatment, the NIHSS and mRS scores in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treat⁃ment, hs-CRP, MMP-9, and MDA levels decreased and SOD levels increased in both groups, with the observation[作者简介] 冯学才(1976-),男,本科,副主任医师,研究方向为内科疾病诊疗等。

Beta-carotene hydroxylase gene

Beta-carotene hydroxylase gene

1O
2. Description of the Prior Art
In carotenoids synthesized by animals, plants and microorganisms,
there are a group of compounds with a hydroxyl group(s) generically
or
a protein consisting of the amino acid sequence as shown in
SEQ ID NO: 2;
a protein which consists of the amino acid sequence as shown
in SEQ ID NO: 2 having deletion, substitution or addition
p -cryptoxanthin
zeaxanthin
This 3 -cryptoxanthin is obtained by introducing a hydroxyl group into one of the two ionone rings present in 6 -carotene. When another hydroxyl group is introduced into a position symmetric to the former position, zeaxanthin is produced (Fig. 1).
C12N 009/14
C12N 015/55
(21) Application No: 199894195
(22) Application Date: 1998.11.27
Priority Data

依达拉奉右莰醇联合丁苯酞对急性缺血性脑卒中患者临床疗效及S100β蛋白水平的影响

依达拉奉右莰醇联合丁苯酞对急性缺血性脑卒中患者临床疗效及S100β蛋白水平的影响

依达拉奉右莰醇联合丁苯酞对急性缺血性脑卒中患者临床疗效及S100β蛋白水平的影响王朝娜① 杨雪华① 【摘要】 目的:探讨急性缺血性脑卒中患者采用依达拉奉右莰醇联合丁苯酞治疗对临床效果及S100β蛋白水平的影响。

方法:选取2021年1月—2023年1月济宁市第三人民医院收治的104例急性缺血性脑卒中患者,以随机数字表法分成研究组(n=52)与对照组(n=52),对照组给予丁苯酞治疗,研究组给予依达拉奉右莰醇联合丁苯酞治疗,比较两组临床疗效、神经功能、日常生活能力、S100β蛋白水平及不良反应。

结果:研究组治疗总有效率(94.23%)较对照组(78.85%)更高,差异有统计学意义(P<0.05);治疗后两组Barthel指数评分均提高,美国国立卫生研究院卒中量表(NIHSS)评分均降低,研究组Barthel指数评分较对照组更高,NIHSS评分较对照组更低,差异均有统计学意义(P<0.05);治疗后两组S100β蛋白水平均降低,研究组较对照组更低,差异均有统计学意义(P<0.05);研究组不良反应发生率(7.69%)与对照组(13.46%)比较差异无统计学意义(P>0.05)。

结论:依达拉奉右莰醇联合丁苯酞用于治疗急性缺血性脑卒中,能够提高临床效果,改善神经功能及S100β蛋白水平,促进日常生活能力提升,避免加重机体不良反应。

【关键词】 依达拉奉右莰醇 丁苯酞 急性缺血性脑卒中 神经功能 S100β蛋白 Effect of Edaravone and Dexborneol Combined with Butylphthalein on Clinical Efficacy and S100β Protein Level in Patients with Acute Ischemic Stroke/WANG Chaona, YANG Xuehua. //Medical Innovation of China, 2024, 21(11): 010-013 [Abstract] Objective: To investigate the effect of Edaravone and Dexborneol combined with Butylphthalein on clinical effect and S100β protein level in patients with acute ischemic stroke. Method: A total of 104 patients with acute ischemic stroke admitted to Jining Third People's Hospital from January 2021 to January 2023 were selected and divided into study group (n=52) and control group (n=52) by random number table method. The control group was treated with Butylphthalein, and the study group was treated with Edaravone and Dexborneol combined with Butylphthalein. The clinical efficacy, neurological function, daily living ability, S100β protein level and adverse reactions were compared between the two groups. Result: The total effective rate of the study group (94.23%) was higher than that of the control group (78.85%), the difference was statistically significant (P<0.05). After treatment, the Barthel index scores of both groups were increased, and the national institutes of health stroke scale (NIHSS) scores were decreased, the Barthel index score of the study group was higher than that of the control group, and the NIHSS score was lower than that of the control group, the differences were statistically significant (P<0.05). After treatment, S100β protein levels were decreased in both groups, and the level in the study group was lower than that in the control group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the study group (7.69%) and the control group (13.46%) (P>0.05). Conclusion: Edaravone and Dexborneol combined with Butylphthalein in the treatment of acute ischemic stroke can improve clinical effect, improve nerve function and S100β protein level, promote the improvement of daily living ability, and avoid aggravating adverse reactions. [Key words] Edaravone and Dexborneol Butylphthalide Acute ischemic stroke Neurological function S100β protein First-author's address: Department of Neurology, Jining Third People's Hospital, Jining 272100, China doi:10.3969/j.issn.1674-4985.2024.11.003①济宁市第三人民医院神经内科 山东 济宁 272100通信作者:王朝娜 急性缺血性脑卒中是一种发病率较高的脑血管疾病,其致病因素较多,包括过氧化、脂质沉积等,易引起动脉粥样硬化,造成局部缺氧缺血,导致脑组织坏死性病变[1]。

不饱和脂肪酸与炎症性肠病因果关系的孟德尔随机化分析 

不饱和脂肪酸与炎症性肠病因果关系的孟德尔随机化分析 

不饱和脂肪酸与炎症性肠病因果关系的孟德尔随机化分析*李 健1 高建淑1,2 赵可可1,2 高鸿亮1,2#新疆医科大学第一附属医院消化病二科1(830054) 新疆医科大学研究生学院2背景:炎症性肠病(IBD )是一种慢性复发性胃肠道炎症性疾病,包括溃疡性结肠炎(UC )和克罗恩病(CD )。

目前尚不清楚不饱和脂肪酸与IBD 之间是否存在因果关系。

目的:采用两样本孟德尔随机化分析探究不饱和脂肪酸与IBD 之间的因果关系。

方法:不饱和脂肪酸和IBD 的全基因组关联研究(GWAS )数据均来源于网络公开数据库。

采用逆方差加权分析法进行两样本孟德尔随机化分析,使用加权中位数法和MR⁃Egger 回归分析验证因果效应,以OR 及其95% CI 评价不饱和脂肪酸与IBD 风险的因果关系。

结果:ω⁃6脂肪酸与CD 无直接因果关系,与UC 有直接因果关系,逆方差加权分析结果显示ω⁃6脂肪酸基因水平每增加一个标准差,UC 风险增加16%(OR =1.16,95% CI : 1.00~1.36,P =0.04)。

而ω⁃3脂肪酸、单不饱和脂肪酸与IBD 之间均未发现因果关系。

结论:ω⁃6脂肪酸可能仅与UC 存在因果关系,ω⁃3脂肪酸、单不饱和脂肪酸与IBD 之间均未发现因果关系。

关键词 脂肪酸类,不饱和; 脂肪酸类,ω⁃6; 炎症性肠病; 结肠炎, 溃疡性; Crohn 病; 孟德尔随机化分析Causal Association Between Unsaturated Fatty Acids and Inflammatory Bowel Disease: A Mendelian Random ⁃ization Analysis LI Jian 1, GAO Jianshu 1,2, ZHAO Keke 1,2, GAO Hongliang 1,2. 1The Second Department of Gastroenterology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi (830054); 2Graduate School of Xinjiang Medical University, UrumqiCorrespondence to:GAOHongliang,Email:*************************.cnBackground: Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease of gastrointestinal tract including ulcerative colitis (UC) and Crohn's disease (CD). It is unclear whether there is a causal association between unsaturated fatty acids and IBD. Aims: A two ⁃sample Mendelian randomization analysis was used to explore the causal association between unsaturated fatty acids and IBD. Methods: The data of the genome⁃wide association study (GWAS) of unsaturated fatty acids and IBD were obtained from web ⁃based public databases. Two ⁃sample Mendelian randomization analysis was performed by using inverse⁃variance weighted analysis, and weight median estimator and MR⁃Egger regression were conducted to validate the association of the causal effect. The causality of unsaturated fatty acids on the risk of IBDwas evaluated by OR and 95% CI . Results: No direct causal association was found between ω⁃6 fatty acids and CD, and a direct causal association was found with UC. Inverse⁃variance weighted analysis showed a 16% increase in the risk of UC for each standard deviation increase in ω⁃6 fatty acid gene levels (OR =1.16, 95% CI : 1.00⁃1.36, P =0.04). However, no causal association was found between ω⁃3 fatty acids, monounsaturated fatty acids and IBD. Conclusions: ω⁃6 fatty acids may be onlycausally associated with UC, and no causal association is found between ω⁃3 fatty acids, monounsaturated fatty acids and IBD.Key words Fatty Acids, Unsaturated; Fatty Acids, Omega⁃6; Inflammatory Bowel Disease; Colitis, Ulcerative; Crohn Disease; Mendelian Randomization AnalysisDOI : 10.3969/j.issn.1008⁃7125.2023.01.003*基金项目:新疆维吾尔自治区自然科学基金杰出青年科学基金项目(2022D01E25)炎症性肠病(inflammatory bowel disease, IBD )是一种免疫介导的胃肠道慢性炎症性疾病,包括溃疡性结肠炎(ulcerative colitis, UC )和克罗恩病(Crohn's disease, CD ),临床特征以腹痛和腹泻为主。

烟碱对小鼠中枢神经炎症的改善作用及其机制

烟碱对小鼠中枢神经炎症的改善作用及其机制

烟碱对小鼠中枢神经炎症的改善作用及其机制刘薇,陈璟莉,严虹,任凌云,彭仕玉华中科技大学同济医学院附属武汉中心医院麻醉科,武汉430014摘要:目的 探讨α7亚基N 型乙酰胆碱受体(α7nAchRs )激动剂烟碱对小鼠中枢神经炎症和认知行为的改善作用及其机制。

方法 取雌性C57BL /6J 小鼠60只,采用随机数字表法分为正常组、模型组、烟碱组、甲基牛扁亭柠檬酸盐(MLA )组,每组各15只。

模型组、烟碱组和MLA 组腹腔注射多聚肌苷酸—多聚胞苷酸[Poly (I ∶C )]12 mg /kg 制备中枢神经炎症模型,正常组腹腔注射等量生理盐水。

烟碱组于造模前30 min 腹腔注射烟碱1 mg /kg ;MLA 组于造模前1 h 腹腔注射α7nAchR 拮抗剂MLA 5 mg /kg ,造模前30 min 腹腔注射烟碱1 mg /kg ;模型组和正常对照组在同一时间点注射等量生理盐水。

造模后3 h ,采用水迷宫实验观察小鼠空间学习记忆能力,记录小鼠穿越原平台次数和逃避潜伏期;采用旷场实验观察小鼠自主运动能力,记录小鼠平均运动速度和运动距离;小鼠处死,取脑组织,采用免疫组化法观察海马及前额叶小胶质细胞激活度,评价中枢神经炎症改变程度;采用qPCR 法检测脑组织炎症因子IL -6、TNF -α、INF -β、INF -α、IL -1β mRNA ,Western blotting 法检测脑组织NF -κB p65蛋白磷酸化水平。

结果 与正常组比较,模型组水迷宫实验潜伏期延长、穿越平台次数减少,旷场实验平均运动速度和运动距离减少,海马及前额叶小胶质细胞激活度增加,脑组织IL -6、TNF -α、INF -β、INF -α、IL -1β表达增加,脑组织NF -κB p65磷酸化水平增加(P 均<0.05);与模型组比较,烟碱组水迷宫检测示潜伏期延长并穿越平台次数增加,旷场实验示平均运动速度以及运动距离均增加,海马及前额叶小胶质细胞激活度降低,脑组织IL -6、TNF -α、INF -β、INF -α、IL -1β表达降低,脑组织NF -κB p65磷酸化水平降低(P 均<0.05);与烟碱组比较,MLA 组水迷宫检测示潜伏期延长并穿越平台次数减少,旷场实验示平均运动速度以及运动距离均减少,海马及前额叶小胶质细胞激活度增加,脑组织IL -6、TNF -α、INF -β、INF -α、IL -1β表达增加,脑组织NF -κB p65磷酸化水平增加(P 均<0.05)。

依达拉奉右莰醇在高龄中重度急性缺血性脑卒中rt-PA静脉溶栓治疗中的应用时机

依达拉奉右莰醇在高龄中重度急性缺血性脑卒中rt-PA静脉溶栓治疗中的应用时机

依达拉奉右莰醇在高龄中重度急性缺血性脑卒中rt-PA静脉溶栓治疗中的应用时机谷亚伟1,楚旭2,赵路静3,洪波3,罗芝宽3,林展增3,李强1,范宏光1,高静珍3,董银华1,王利军1,陈念41 南开大学附属第四中心医院神经内科,天津300140;2 保定市徐水区人民医院内科;3 南开大学附属第四中心医院急诊科;4 天津市宁河区医院神经内科摘要:目的 探讨依达拉奉右莰醇在高龄中重度急性缺血性脑卒中(AIS)重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗中的应用时机。

方法 选择rt-PA静脉溶栓救治的221例高龄中重度AIS患者,随机分为对照组70例、早期组75例、晚期组76例。

对照组接受rt-PA静脉溶栓治疗,早期组在rt-PA静脉溶栓治疗启动后即刻给予依达拉奉右莰醇治疗,晚期组在rt-PA静脉溶栓24 h后给予依达拉奉右莰醇治疗。

于治疗7 d时采用NIHSS评分评价神经功能改善情况,治疗90 d时采用mRS评分评价预后情况,比较三组短期疗效和长期疗效;观察24 h症状性颅内出血发生率、14 d颅外系统性并发症发生率和90 d病死率,比较三组治疗安全性。

结果 三组7 d神经功能改善率、90 d预后良好率比较,早期组和晚期组均高于对照组,且早期组高于晚期组(P均<0.05)。

三组24 h症状性颅内出血发生率、14 d颅外系统性并发症发生率比较,早期组低于晚期组和对照组(P均<0.05),晚期组与对照组比较差异无统计学意义(P>0.05)。

三组90 d病死率比较,早期组和晚期组均低于对照组,且早期组低于晚期组(P均<0.05)。

结论 高龄中重度AIS患者rt-PA静脉溶栓后即刻应用依达拉奉右莰醇可提高rt-PA静脉溶栓治疗的有效性和安全性,减少并发症的发生,改善患者预后。

关键词:依达拉奉右莰醇;静脉溶栓;急性缺血性脑卒中;组织型纤溶酶原激活剂doi:10.3969/j.issn.1002-266X.2024.02.003中图分类号:R743.3 文献标志码:A 文章编号:1002-266X(2024)02-0013-05Timing of edaravone dexborneol in intravenous thrombolysis with rt-PA for elderly patients with moderate to severe acute ischemic strokeGU Yawei1,CHU Xu,ZHAO Lujing,HONG Bo,LUO Zhikuan,LIN Zhanzeng,LI Qiang,FAN Hongguang,GAO Jingzhen, DONG Yinhua, WANG Lijun, CHEN Nian1 Department of Neurology, Tianjin Fourth Central Hospital Affiliated to Nankai University, Tianjin 300140, ChinaAbstract:Objective To investigate the timing of edaravone dexborneol in intravenous thrombolysis with recombi⁃nant tissue plasminogen activator (rt-PA)for elderly patients with moderate to severe acute ischemic stroke (AIS).Methods A total of 221 patients older than 80 years with moderate to severe AIS receiving intravenous thrombolysis with rt-PA were divided into the control group (70 cases received intravenous thrombolytic therapy with rt-PA), the early group (n=75,edaravone dexborneol began immediately after intravenous thrombolysis with rt-PA)and the late group (n=76,edaravone dexborneol started at 24 h after intravenous thrombolysis with rt-PA).The neurologic improvement rate at 7 days and good prognosis rate at 90 days were used to evaluate the efficacy. The short-term efficacy and long-term efficacy of the three groups were compared. The incidences of symptomatic intracranial hemorrhage within 24 h, extracranial compli⁃cations within 14 days and mortality within 90 days were observed,and the safety of the three groups was compared.Results The neurologic improvement rate at 7 days and the good prognosis rate at 90 days of the early group and the late group were higher than those of the control group,and those were higher in the early group than in the late group (all P<0.05).The incidences of symptomatic intracranial hemorrhage within 24 h and extracranial complications within 14 days in the early group were lower than those in the late group and control group (all P<0.05), while there were no statisti⁃基金项目:天津市卫生健康科技项目(ZC20073);天津市第四中心医院2022年度优秀青年人才培养基金(tjdszxyy20220012)。

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Introduction
Carotenoids are a diverse class of C40 isoprenoids with multiple physiological and nutritional roles in plants, algae, bacteria, and fungi (1-3). Several carotenoids such as lycopene, -carotene, zeaxanthin, and astaxanthin are important industrially as nutrient supplements, food colorants, and feed additives. Scientific interest in dietary carotenoids has increased in recent years due to their beneficial effects on human health, such as a reduced risk of cancer and enhancement of immune system function (3), which are attributed to their antioxidative potential. Carotenoids used in industry are mostly manufactured using chemical synthesis or are natural extracts or concentrates. The increasing interest in microbial carotenoid sources is related to consumer preferences for natural additives and the potential cost effectiveness of creating carotenoids via microbial biotechnology (4). In the past few decades, progress has been made within the field of biosynthesis of carotenoid in bacteria, fungi, and plants (2, 5). Lycopene, zeaxanthin, and astaxanthin have been successfully synthesized in non-carotenogenic Escherichia coli
Division of Applied Life Science (BK21), EB-NCRC and PMBBRC, and Division of Forest Science, Gyeongsang National University, Jinju 660-701, Korea, Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-503, Korea, and Department of Chemical Engineering, University of California, Berkeley, California 94720-1462
When pT-LYCm4 containing lycopene synthetic genes was co-transformed with pSUcrtY or pSHcrtY containing crtY gene of Pantoea ananatis (P. ananatis) or Pantoea agglomerans (P. agglomerans), -carotene productions of 36 and 35 mg/L were obtained, respectively. No lycopene was detected in the -carotene production culture. pT-HB, constructed by addition of P. ananatis crtY gene into pT-LYCm4, was used for co-transformation with pSdxs and pSSN12Didi, which increased isopentenyl diphosphate and dimethylallyl diphosphate synthesis. -Carotene production significantly increased 1.5-fold (51 mg/L) with the amplification of the dxs gene through pSdxs and 4-fold (135 mg/L) with the mevalonate bottom pathway of pSSN12Didi in the presence of 3.3 mM mevalonate. The pT-DHB, constructed by integrating the dxs gene into pT-HB, was used for cotransformation of Escherichia coli (E. coli) harboring pSSN12Didi, resulting in -carotene production of 141 mg/L. Recombinant E. coli harboring pT-DHB and pSSN12Didi was used to maximize -carotene production by adjusting the available amounts of glycerol, a carbon source, and mevalonate, the precursor of the mevalonate bottom pathway. When recombinant E. coli was given 16.5 mM mevalonate and 2.5% (w/v) glycerol, -carotene production of 503 mg/L in concentration and 49.3 mg/g DCW in content was obtained at 144 h, which was the highest level of carotenoid production in E. coli ever reported in the literature.
* Corresponding author. Telephone: +82-55-751-6522. Fax: 82-55-7599363. E-mail: swkim@gsnu.ac.kr. † Division of Applied Life Science (BK21), Gyeongsang National University. ‡ These authors contributed equally to this work. § EB-NCRC and PMBBRC, Gyeongsang National University. | Division of Forest Science, Gyeongsang National University. ⊥ Konkuk University. ¶ University of California, Berkeley.
Sang-Hwal Yoon,†,‡ Hye-Min Park,†,‡ Ju-Eun Kim,† Sook-Hee Lee,† Myung-Suk Choi,§,| Jae-Yean Kim,†,§ Deok-Kun Oh,⊥ Jay D. Keasling,¶ and Seon-Won Kim*,†,§
10.1021/bp070012p CCC: $37.00
(E. coli) (6-8). However, little progress has been made in producing -carotene in E. coli using metabolic engineering. Of all known carotenoids, -carotene is believed to be the most important in human nutrition. Animals, in general, are unable to synthesize retinoids (vitamin A and its derivatives) de novo and rely on a dietary supply of these compounds in the form of provitamin A carotenoid, -carotene from plants (9). Retinoids are essential components for vision and are also essential in the maintenance of normal growth and development, immunity, and reproduction (10). The coexpression of four exogenous genes in E. coli cellss GGPP synthase (crtE), phytoene synthase (crtB), phytoene desaturase (crtI), and lycopene cyclase (crtY)sis sufficient for the conversion of isopentenyl diphosphate (IPP) and farnesyl diphosphate (FPP) to a yellow-colored -carotene (Figure 1) (11). High-yield production of carotenoids in engineered microbial hosts requires optimizing the availability of isoprenoid precursor pool of IPP and DMAPP (dimethylallyl diphosphate) and balancing the expression of carotenogenic genes for efficient transformation of the precursors to the desired carotenoid compounds. Two pathways for the synthesis of IPP and DMAPP exist: the well-known mevalonate pathway and the newly discovered 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway (12). Eukaryotes usually use the mevalonate pathway exclusively to convert acetyl-CoA to IPP, which is subsequently isomerized to DMAPP. Prokaryotes, with some exceptions (13), use the MEP pathway to produce IPP and DMAPP separately through a branch point (14). Plants and Streptomycetes use both pathways (15, 16). The MEP pathway has been engineered to
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