OICR-9429_DataSheet_MedChemExpress
USP 通用章节目录
USP29-通用章节指导目录(附录)Guide to General Chapters 通用章节指导目录中此颜色并且带有“***”的为新增内容。
General Requirements for Test and Assays检查与含量分析的一般要求＜1＞INJECTIONS……2455注射剂＜11＞USP REFERENCE STANDARDS……2458USP对照品Apparatus for Test and Assays用于检查与含量分析的器具＜16＞AUTOMATED METHODS OF ANAL YSIS……2491自动化分析方法＜21＞THERMOMETERS……2497温度计＜31＞VOLUMETRIC APPARATUS……2497容量器具＜41＞WEIGHTS AND BALANCES……2499砝码与天平Microbiological Tests 微生物检查法＜51＞ANTIMICROBIAL EFFECTIVENESS TESTING……2499抗菌剂有效性检查法＜55＞BIOLOGICAL INDICATORS—RESISTANCE PERFORMANCE TESTS (2501)生物指示剂－耐药性实验＜61＞MICROBIAL LIMIT TESTS……2503微生物限度检查法＜71＞STERILITY TESTS……2508无菌检查法Biological tests and assays生物检查法与测定法＜81＞ANTIBIOTICS—MICROBIAL ASSAYS……2513抗生素－微生物测定＜85＞BACTERIAL ENDOTOXINS TEST……2521细菌内毒素检查法＜87＞BIOLOGICAL REACTIVITY TESTS, IN VITRO……2525体外的生物反应性检查法＜88＞BIOLOGICAL REACTIVITY TESTS, IN VIVO……2526体内的生物反应性检查法＜91＞CALCIUM PANTOTHENATE ASSAY……2530泛酸钙测定法＜111＞DESIGN AND ANAL YSIS OF BIOLOGICAL ASSAYS……2531 生物测定法的设计与分析＜115＞DEXPANTHENOL ASSAY……2543右泛醇（拟胆碱药）测定法＜121＞INSULIN ASSAYS……2544胰岛素测定法＜141＞PROTEIN—BIOLOGICAL ADEQUACY TEST……2546蛋白质－生物适应性试验＜151＞PYROGEN TEST……2546热原检查法＜161＞TRANSFUSION AND INFUSION ASSEMBLIES AND SIMILAR MEDICAL DEVICES (2547)输血输液用具以及相类似的医疗器械＜171＞VITAMIN B12 ACTIVITY ASSAY……2548维生素B12活性测定法Chemical Tests and assays化学实验与测定法＜181＞IDENTIFICATION—ORGANIC NITROGENOUS BASES (2549)鉴别－有机氮碱？＜191＞IDENTIFICATION TESTS—GENERAL……2550鉴别实验－通用＜193＞IDENTIFICATION—TETRACYCLINES……2551鉴别－四环素＜197＞SPECTROPHOTOMETRIC IDENTIFICATION TESTS......2552分光光度计鉴别实验＜201＞THIN-LAYER CHROMATOGRAPHIC IDENTIFICATION TEST.. (2553)薄层色谱鉴别实验Limit Test 限度检查法＜206＞ALUMINUM……2554铝＜211＞ARSENIC……2554砷＜221＞CHLORIDE AND SULFATE……2555氯和硫＜223＞DIMETHYLANILINE……2555二甲基苯胺＜226＞4-EPIANHYDRO-TETRACYCLINE……25564－？－四环素＜231＞HEA VY METALS……2556重金属＜241＞IRON……2557铁＜251＞LEAD……2558铅＜261＞MERCURY……2558汞＜271＞READIL Y CARBONIZABLE SUBSTANCES TEST……2560易碳化物检查法＜281＞RESIDUE ON IGNITION……2560灼烧残渣＜291＞SELENIUM……2560硒Other Tests and Assays 其它检查法与测定法＜301＞ACID-NEUTRALIZING CAPACITY……2561酸中和容量＜311＞ALGINATES ASSAY……2562藻酸盐测定法＜331＞AMPHETAMINE ASSAY……2562苯丙胺测定法<341> ANTIMICROBIAL AGENTS—CONTENT……2563 抗菌剂－含量<345> Assay for Citric Acid/Citrate and Phosphate……2565 柠檬酸/柠檬酸盐和磷酸盐的测定＜351＞ASSAY FOR STEROIDS……2565类固醇（甾类化合物）测定法＜361> BARBITURATE ASSAY……2565 巴比妥类药物测定法＜371＞COBALAMIN RADIOTRACER ASSAY……2566钴铵素放射性跟踪剂测定法＜381＞ELASTOMERIC CLOSURES FOR INJECTIONS……2567 注射剂的弹性密封件＜391＞EPINEPHRINE ASSAY……2567肾上腺测定法＜401＞FATS AND FIXED OILS……2568脂肪与混合油＜411＞FOLIC ACID ASSAY……2571叶酸测定法＜425＞IODOMETRIC ASSAY—ANTIBIOTICS……2572碘量检查法－抗生素＜429＞LIGHT DIFFRACTION MEASUREMENT OF PARTICLE SIZE (2572)粒子尺寸的光衍射测量＜431＞METHOXY DETERMINA TION……2575甲氧基测定法＜441＞NIACIN OR NIACINAMIDE ASSAY……2576烟酰或烟酰胺测定法＜451＞NITRITE TITRATION……2578亚硝酸盐滴定＜461＞NITROGEN DETERMINA TION……2578氮测定法＜466＞ORDINARY IMPURITIES……2579一般杂质＜467＞ORGANIC VOLATILE IMPURITIES……2580有机的易挥发杂质＜471＞OXYGEN FLASK COMBUSTION……2590氧瓶燃烧法＜481＞RIBOFLAVIN ASSAY……2590核黄素测定法＜501＞SALTS OF ORGANIC NITROGENOUS BASES……2591有机氮盐＜511＞SINGLE-STEROID ASSAY……2591单一的类固醇测定法＜521＞SULFONAMIDES……2592磺胺制剂＜531＞THIAMINE ASSAY……2593硫胺素测定法＜541＞TITRIMETRY……2593滴定法＜551＞ALPHA TOCOPHEROL ASSAY……2596α－维生素E测定法＜561＞ARTICLES OF BOTANICAL ORIGIN……2596植物起源的药品＜563＞IDENTIFICATION OF ARTICLES OF BOTANICAL ORIGIN……2603植物药品的鉴别＜565＞BOTANICAL EXTRACTS……2609植物提取＜571＞VITAMIN A ASSAY……2611维生素A的测定法＜581＞VITAMIN D ASSAY……2612维生素D的测定法＜591＞ZINC DETERMINATION……2616锌的测定法Physical Test and Determinations物理检查与测定法INHALERS, AND DRY POWDER ＜601＞AEROSOLS, NASAL SPRAYS,USP28METERED-DOSEINHALERS……2617气溶胶，鼻用喷雾剂，定量吸入器与干粉吸入器＜611＞ALCOHOL DETERMINATION……2637乙醇测定法＜616＞BULK DENSITY AND TAPPED DENSITY……2638堆密度与拍实密度＜621＞CHROMATOGRAPHY…….2639色谱法＜631＞COLOR AND ACHROMICITY……2651呈色与消色＜641＞COMPLETENESS OF SOLUTION……2652完全溶解＜643＞TOTAL ORGANIC CARBON……2652总有机碳＜645＞WA TER CONDUCTIVITY……2653水电导率＜651＞CONGEALING TEMPERA TURE……2654凝点温度＜661＞CONTAINERS……2655容器＜671＞CONTAINERS—PERMEATION……2663容器－渗透＜691＞COTTON……2664棉花＜695＞CRYSTALLINITY……2665结晶性＜696＞Crystallinity Determination By Solution Calorimetry……2666 通过溶液量热学测定结晶性＜698＞DELIVERABLE VOLUME……2667可转移的体积＜699＞DENSITY OF SOLIDS……2669固体密度＜701＞DISINTEGRATION……2670崩解时限***＜701＞Disintegration (Harmonized Chapter, Official April 1,2006)………..2671崩解时限（协调的章节，法定日期，2006.4.1）＜711＞DISSOLUTION……2673 溶出度***＜711＞Dissolution (Harmonized Chapter, Official April 1,2006)………..2675 溶出度（协调的章节，法定日期，2006.4.1）＜721＞DISTILLING RANGE……2682馏程＜724＞DRUG RELEASE……2682药物释放度***＜724＞Drug releasee (Harmonized Chapter, Official April 1,2006)………..2690药物释放度（协调的章节，法定日期，2006.4.1）＜726＞ELECTROPHORESIS……2694电泳＜727＞CAPILLARY ELECTROPHORESIS……2696毛细管电泳法***＜730＞Plasma Spectrochemistry….2700 血浆光谱化学＜731＞LOSS ON DRYING……2704干燥失重＜733＞LOSS ON IGNITION……2704灼烧失重＜736＞MASS SPECTROMETRY……2705 质谱＜741＞MELTING RANGE OR TEMPERATURE……2708熔距或熔点＜751＞METAL PARTICLES IN OPHTHALMIC OINTMENTS……2709眼用软膏中的金属粒子＜755＞MINIMUM FILL……2710最低装填量＜761＞NUCLEAR MAGNETIC RESONANCE……2710核磁共振＜771＞OPHTHALMIC OINTMENTS……2715眼用软膏＜776＞OPTICAL MICROSCOPY……2716光学显微镜＜781＞OPTICAL ROTATION……2718旋光＜785＞OSMOLALITY AND OSMOLARITY……2718同渗重摩与同渗容摩＜786＞PARTICLE SIZE DISTRIBUTION ESTIMATION BY ANAL YTICAL SIEVING (2720)通过筛分法估算粒子分布＜788＞PARTICULATE MATTER IN INJECTIONS……2722注射剂中的颗粒＜789＞PARTICULATE MATTER IN OPHTHALMIC SOLUTIONS……2729眼用溶液中的颗粒＜791＞pH (2730)＜795＞PHARMACEUTICAL COMPOUNDING—NONSTERILE PREPARATIONS (2731)药物混合－非无菌制剂＜797＞PHARMACEUTICAL COMPOUNDING—STERILE PREPARATIONS (2735)药物混合－无菌制剂＜801＞POLAROGRAPHY……2752极谱法＜811＞POWDER FINENESS……2754粉剂细度＜821＞RADIOACTIVITY……2755放射性＜823＞RADIOPHARMACEUTICALS FOR POSITRON EMISSION TOMOGRAPHY —COMPOUNDING……2763用于正电子发射断层摄影术的放射性药物＜831＞REFRACTIVE INDEX……2766折光率＜841＞SPECIFIC GRA VITY……2766比重＜846＞SPECIFIC SURFACE AREA……2767 比表面积＜851＞SPECTROPHOTOMETRY AND LIGHT-SCA TTERING……2770分光光度计与光散射＜861＞SUTURES—DIAMETER…2775缝线－直径＜871＞SUTURES—NEEDLE ATTACHMENT……2775缝线－穿孔实验＜881＞TENSILE STRENGTH…..2776张力＜891＞THERMAL ANAL YSIS……2776热分析＜905＞UNIFORMITY OF DOSAGE UNITS……2778制剂单位的含量均匀度＜905＞UNIFORMITY OF DOSAGE UNITS (Harmonized Chapter, Official April 1,2006)……2780制剂单位的含量均匀度（协调的章节2006.4.1）＜911＞VISCOSITY……2785粘度＜921＞WA TER DETERMINA TION……2785水测定法＜941＞X-RAY DIFFRACTION……2788X光衍射General Information通用信息＜1010＞ANAL YTICAL DATA—INTERPRETA TION AND TREATMENT (2790)分析数据－解释与处理＜1015＞AUTOMA TED RADIOCHEMICAL SYNTHESIS APPARATUS (2801)放射性自动合成装置＜1031＞THE BIOCOMPATIBILITY OF MATERIALS USED IN DRUG CONTAINERS, MEDICAL DEVICES, AND IMPLANTS (2802)用于药物容器、医疗设施和植入剂的材料的生物相容性＜1035＞BIOLOGICAL INDICATORS FOR STERILIZATION……2811灭菌用生物指示剂＜1041＞BIOLOGICS……2814生物制剂***＜1043＞Ancillary Material for Cell, Gene, and Tissue-Engineered Products…….2814 细胞，基因与组织设计产品的辅助材料＜1045＞BIOTECHNOLOGY-DERIVED ARTICLES……2821生物技术提取产品＜1046＞CELL AND GENE THERAPY PRODUCTS……2831细胞与基因治疗产品＜1047＞BIOTECHNOLOGY-DERIVED ARTICLES—TESTS……2858生物技术产品－检查法＜1048＞QUALITY OF BIOTECHNOLOGICAL PRODUCTS: ANAL YSIS OF THE EXPRESSION CONSTRUCT IN CELLS USED FOR PRODUCTION OF r-DNA DERIVED PROTEIN PRODUCTS1 (2883)生物产品质量：从蛋白质产品中提取的r-DNA产品在细胞中表达结构的分析＜1049＞QUALITY OF BIOTECHNOLOGICAL PRODUCTS: STABILITY TESTING OF BIOTECHNOLOGICAL/BIOLOGICAL PRODUCTS1 (2884)生物技术产品的质量：生物技术/生物产品的稳定性实验＜1050＞VIRAL SAFETY EV ALUA TION OF BIOTECHNOLOGY PRODUCTS DERIVED FROM CELL LINES OF HUMAN OR ANIMAL ORIGIN (2887)从人或动物细胞中提取的生物技术产品的病毒安全性评估＜1051＞CLEANING GLASS APPARATUS……2896玻璃容器的清洗＜1061＞COLOR—INSTRUMENTAL MEASUREMENT……2896显色－仪器测量***＜1065＞Ion Chromatography………2898 离子色谱法＜1074＞EXCIPIENT BIOLOGICAL SAFETY EV ALUA TION GUIDELINES (2900)赋形剂（辅料）生物安全性评估指导＜1075＞GOOD COMPOUNDING PRACTICES……2903好的混合操作＜1078＞GOOD MANUFACTURING PRACTICES FOR BULK PHARMACEUTICAL EXCIPIENTS (2906)批药品赋形剂的生产管理规范***＜1079＞Good Storage and Shipping Practices……2915 良好的贮存与船运规范＜1081＞GEL STRENGTH OF GELATIN……2920白凝胶的凝胶强度＜1086＞IMPURITIES IN OFFICIAL ARTICLES……2920药典物品中的杂质＜1087＞INTRINSIC DISSOLUTION……2923内部的溶出度＜1088＞IN VITRO AND IN VIVO EV ALUA TION OF DOSAGE FORMS (2924)体内与体外的剂型的评估＜1090＞IN VIVO BIOEQUIV ALENCE GUIDANCES……29291体内生物等效性指导＜1091＞LABELING OF INACTIVE INGREDIENTS……2968非活性成分的标示＜1101＞MEDICINE DROPPER……2969医用滴管＜1111＞MICROBIOLOGICAL ATTRIBUTES OF NONSTERILE PHARMACEUTICAL PRODUCTS (2969)非无菌药品中的微生物分布＜1116＞MICROBIOLOGICAL EV ALUA TION OF CLEAN ROOMS AND OTHER CONTROLLED ENVIRONMENTS……2969洁净的房间与其它可控环境的微生物评估＜1118＞MONITORING DEVICES—TIME, TEMPERATURE, AND HUMIDITY (2976)监控装置－时间、温度与湿度＜1119＞NEAR-INFRARED SPECTROPHOTOMETRY……2979近红外分光光度测定法***＜1120＞Raman Spectrophotometry……..2983 Raman分光光度测定法＜1121＞NOMENCLATURE……2988命名***＜1136＞Packaging－Unit-of-Use……2989包装－单元使用＜1146＞PACKAGING PRACTICE—REPACKAGING A SINGLE SOLID ORAL DRUG PRODUCT INTO A UNIT-DOSE CONTAINER……2990 包装操作－将单一固体口服药品产品再包装成单元剂量＜1150＞PHARMACEUTICAL STABILITY……2994药物稳定性＜1151＞PHARMACEUTICAL DOSAGE FORMS……2996药物剂型＜1160＞PHARMACEUTICAL CALCULATIONS IN PRESCRIPTION COMPOUNDING (3006)按处方混合的药物的计算＜1171＞PHASE-SOLUBILITY ANAL YSIS……3016相溶解分析***＜1174＞Powder Flow….3017 粉末流动性＜1176＞PRESCRIPTION BALANCES AND VOLUMETRIC APPARATUS….3020 处方天平与容量器具***＜1177＞Good Packaging Practices….3021 良好的包装操作***＜1178＞Good Repackaging Practices….3023 良好的再包装操作＜1181＞SCANNING ELECTRON MICROSCOPY……3025扫描电子显微镜＜1191＞STABILITY CONSIDERATIONS IN DISPENSING PRACTICE……3029 分装操作中稳定性考察＜1196＞PHARMACOPEIAL HARMONIZATION……3031药典的一致性＜1207＞STERILE PRODUCT PACKAGING—INTEGRITY EV ALUATION (3035)无菌产品包装－完整性评估＜1208＞STERILITY TESTING—V ALIDATION OF ISOLATOR SYSTEMS (3037)无菌实验－隔离系统的验证＜1209＞STERILIZATION—CHEMICAL AND PHYSICOCHEMICAL INDICATORS AND INTEGRATORS……3040灭菌－化学与物理化学的指示剂以及二者的综合＜1211＞STERILIZATION AND STERILITY ASSURANCE OF COMPENDIAL ARTICLES (3041)药典物品中的灭菌与灭菌保证＜1216＞TABLET FRIABILITY……3046片剂的脆碎度＜1221＞TEASPOON……3047茶匙＜1222＞TERMINALL Y STERILIZED PHARMACEUTICAL PRODUCTS—PARAMETRIC RELEASE……3047最终灭菌产品－放行参数＜1225＞V ALIDATION OF COMPENDIAL METHODS……3050药典方法的验证＜1227＞V ALIDATION OF MICROBIAL RECOVERY FROM PHARMACOPEIAL ARTICLES (3053)从药物中回收微生物的验证＜1230＞W ATER FOR HEALTH APPLICATIONS……3055健康用水＜1231＞W ATER FOR PHARMACEUTICAL PURPOSES……3056制药用水＜1241＞W ATER–SOLID INTERACTIONS IN PHARMACEUTICAL SYSTEMS (3074)在药物系统中水与固体的相互作用＜1251＞WEIGHING ON AN ANAL YTICAL BALANCE……3076关于分析天平的称重***＜1265＞Written Prescription Drug Information－Guidelines……….3078 书面的处方药信息－指南Dietary Supplements营养补充剂General Tests and Assays 一般检查法与测定法＜2021＞MICROBIAL ENUMERATION TESTS—NUTRITIONAL AND DIETARY SUPPLEMENTS (3080)微生物数量实验－营养与食品添加剂＜2022＞MICROBIOLOGICAL PROCEDURES FOR ABSENCE OF SPECIFIED MICROORGANISMS—NUTRITIONAL AND DIETARY SUPPLEMENTS (3083)不得检出特定微生物的程序－营养与营养补充剂＜2023>MICROBIOLOGICAL A TTRIBUTES OF NONSTERILE NUTRITIONAL AND DIETARY SUPPLEMENTS……3087非无菌的营养与食品添加剂中的微生物分布<2040>DISINTEGRATION AND DISSOLUTION OF DIETARY SUPPLEMENTS (3089)食品添加剂的崩解与溶出<2091>WEIGHT VARIATION OF DIETARY SUPPLEMENTS……3092食品添加剂的重量差异<2750>MANUFACTURING PRACTICES FOR DIETARY SUPPLEMENTS (3093)食品添加剂的生产操作。
HPLC法测定心脉通片中葛根素的含量
HP LC 法测定心脉通片中葛根素的含量黄燕玲 曾志红 郑文涛 莫剑虹3 周健池33(广东邦民制药厂有限公司 广东529000)3苏州大学2002年毕业生;33广东药学院2002年毕业生关键词:心脉通片;葛根素;高效液相色谱法中图分类号:R92712 文献标识码:A 文章编号:1007-9939(2002)04-0010-02 心脉通片是由当归、葛根、三七、毛冬青、丹参等十味中药组成的薄膜衣片,功效为活血化瘀,通脉养心,降压降脂。
用于治疗高血压、高血脂症等。
卫生部药品标准[WS 3-B -1109-92]对心脉通片没有含量测定指标,为能控制其内在质量,参照《中国药典》一部[1],研究建立关于HP LC 测定心脉通片中葛根素的含量方法,本法操作简便,准确,线性好,可作为控制心脉通片质量的依据之一。
1 仪器与试药TSP -100高效液相色谱仪 (TSP -100泵,TSP -UV100检测器,ANAST AR 色谱工作站)。
葛根素对照品752-200108 (中国药品生物制品检定所),心脉通片样品(广东邦民制药厂有限公司),甲醇(色谱纯)。
2 实验方法及结果2.1 色谱条件 色谱柱:K romasil C 18(4.6mm ×200mm ,5μm );流动相:甲醇-水(30∶70);流速:110ml Πmin ;检测波长:250nm 。
理论板数按葛根素计算不应低于2000。
2.2 阴性对照试验 照处方比例制备葛根的阴性对照样品,依“样品测定”项下制备供试品溶液,进样分析,结果表明,其他成分对葛根素测定无干扰。
2.3 线性试验 精密称取葛根素对照品10mg ,置50ml 容量瓶中,加入30%乙醇溶解并稀释至刻度,摇匀。
分别取1、2、4、8、16ml 置50ml 容量瓶中,加入30%乙醇稀释至刻度,摇匀。
各取10μl 注入液相色谱仪,记录色谱图。
以峰面积为纵坐标,对照品浓度为横坐标,进行回归分析,得回归方程:Y =-18657.7+54112.8X r =0.9990浓度在4～64μg Πml 范围内线性关系良好。
ppt3929
网状型聚乙烯亚胺衍生物 介导的靶向药物用于肿瘤治疗
姓名：周朋
目录
背景介绍 研究方案 结果及分析 结论
背景介绍
近年来，基因治疗已成为最活跃的研究领域之一。其在遗传疾病， 心血管疾病及肿瘤等方面取得突破性进展。目前的基因治疗载体可分为 病毒型载体和非病毒型载体，病毒性载体具有转导效率高而被较多应用 的优点，但也能诱导宿主免疫反应，装载容量有限等缺点。而非病毒载 体具有安全性高，容易制备和修饰，基因容量大的优势。 聚乙烯亚胺（polyethylenimine，PEI）是至今设计最为成功的一种非 病毒载体聚合物，聚乙烯亚胺含阳离子，具有较强的结合pDNA的能力。 此外PEI几乎在任何pH条件下均具有吸收质子的能力，因此可保护pDNA 免受溶酶体降解，PEI的转染效率较高，但细胞毒性很大，严重限制了 其应用。PEI的毒性与分子量有关，分子量越大，细胞毒性越大，为了克 服毒性问题，人们使用低分子量PEI进行基因转染，虽然其毒性小，但转 染效率却大大降低。 依普罗沙坦（ES）是一种可以与肿瘤细胞表面AT1受体特异性结合的 化学药物，该药物水溶性较差，其分子结构中有两个羧基可与PEI上的氨 基形成偶联物，本研究中ES起着重要作用：首先ES作为一个连接臂，将 低分子量的PEI链接成高分子量的PEI，大大降低毒性的同时提高了转染 效率。其次，ES作为靶向基因可以与某些肿瘤细胞表面高表达AT1受体特
通过分光光度法测定pDNA与ESP结 合的上清液的光密度的量 。 根据该计算结 果，装载效率（LE％），在12另外的N / P比约为80％，此外，N/ P比持续增加， 装载效率（LE％）几乎没有变化。
一个成功的基因传递系统必须能够 保护DNA免受血清，细胞外基质，黏膜 中核酸酶的降解，在N/P于8-10之间， DNA受到良好的保护
1-丙醇 msds - sigma-aldrich说明书
SIGMA-ALDRICHMaterial Safety Data SheetVersion 4.2Revision Date 12/18/2012Print Date 05/07/20131. PRODUCT AND COMPANY IDENTIFICATIONProduct name :1-PropanolProduct Number : 402893Brand : Sigma-AldrichSupplier: Sigma-Aldrich3050 Spruce StreetSAINT LOUIS MO 63103 USATelephone : +1 800-325-5832 Fax: +1 800-325-5052 Emergency Phone # (For both supplier and manufacturer): (314) 776-6555Preparation Information: Sigma-Aldrich CorporationProduct Safety - Americas Region 1-800-521-89562. HAZARDS IDENTIFICATIONEmergency OverviewOSHA HazardsFlammable liquid, Target Organ Effect, Irritant Target Organs Nerves., LiverGHS ClassificationFlammable liquids (Category 2)Acute toxicity, Inhalation (Category 5) Skin irritation (Category 3)Serious eye damage (Category 1)Specific target organ toxicity - single exposure (Category 3)GHS Label elements, including precautionary statements PictogramSignal word DangerHazard statement(s) H225 Highly flammable liquid and vapour. H316 Causes mild skin irritation. H318 Causes serious eye damage. H333 May be harmful if inhaled. H336 May cause drowsiness or dizziness.Precautionary statement(s) P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, ifpresent and easy to do. Continue rinsing.HMIS ClassificationHealth hazard:2Chronic Health Hazard:*Flammability:3Physical hazards:0NFPA RatingHealth hazard:2Fire:3Reactivity Hazard:0Potential Health EffectsInhalation May be harmful if inhaled. Causes respiratory tract irritation.Vapours may causedrowsiness and dizziness.Skin May be harmful if absorbed through skin. Causes skin irritation.Eyes Causes eye irritation.Ingestion May be harmful if swallowed.3. COMPOSITION/INFORMATION ON INGREDIENTSSynonyms : Propyl alcoholFormula : C3H8OMolecular Weight : 60.10 g/mol4. FIRST AID MEASURESGeneral adviceConsult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.If inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.In case of skin contactWash off with soap and plenty of water. Consult a physician.In case of eye contactRinse thoroughly with plenty of water for at least 15 minutes and consult a physician.If swallowedDo NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.5. FIREFIGHTING MEASURESConditions of flammabilityFlammable in the presence of a source of ignition when the temperature is above the flash point. Keep away from heat/sparks/open flame/hot surface. No smoking.Suitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Special protective equipment for firefightersWear self contained breathing apparatus for fire fighting if necessary.Hazardous combustion productsHazardous decomposition products formed under fire conditions. - Carbon oxidesFurther informationUse water spray to cool unopened containers.6. ACCIDENTAL RELEASE MEASURESPersonal precautionsUse personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove allsources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosiveconcentrations. Vapours can accumulate in low areas.Environmental precautionsPrevent further leakage or spillage if safe to do so. Do not let product enter drains.Methods and materials for containment and cleaning upContain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place incontainer for disposal according to local regulations (see section 13).7. HANDLING AND STORAGEPrecautions for safe handlingAvoid inhalation of vapour or mist.Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.Conditions for safe storageKeep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.8. EXPOSURE CONTROLS/PERSONAL PROTECTIONComponents with workplace control parametersPersonal protective equipmentRespiratory protectionWhere risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If therespirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and componentstested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).Hand protectionHandle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use inaccordance with applicable laws and good laboratory practices. Wash and dry hands.Full contactMaterial: Nitrile rubberMinimum layer thickness: 0.4 mmBreak through time: > 480 minMaterial tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)Splash protectionMaterial: Nitrile rubberMinimum layer thickness: 0.2 mmBreak through time: 72 minMaterial tested:Dermatril® P (KCL 743 / Aldrich Z677388, Size M)datasource:KCLGmbH,D-36124Eichenzell,phone+49(0)665987300,******************,testmethod:EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact thesupplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our customers. It should not be construed asoffering an approval for any specific use scenario.Eye protectionTightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin and body protectionComplete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protectiveequipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.Hygiene measuresHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.9. PHYSICAL AND CHEMICAL PROPERTIESAppearanceForm clear, liquidColour colourlessSafety datapH 8.5 at 200 g/l at 20 °C (68 °F)Melting point/range: -127 °C (-197 °F) - lit.Meltingpoint/freezing pointBoiling point 97 °C (207 °F) - lit.Flash point 22 °C (72 °F) - closed cupIgnition temperature 395 °C (743 °F)Auto-ignitionno data availabletemperatureLower explosion limit 2.1 %(V)Upper explosion limit 13.7 %(V)Vapour pressure 19.3 hPa (14.5 mmHg) at 20 °C (68 °F) Density 0.804 g/cm3 at 25 °C (77 °F)Water solubility completely solublePartition coefficient:n-octanol/waterlog Pow: 0.25 - 0.34Relative vapor density 2.07- (Air = 1.0)Odour no data availableOdour Threshold no data availableEvaporation rate 110. STABILITY AND REACTIVITYChemical stabilityStable under recommended storage conditions.Possibility of hazardous reactionsVapours may form explosive mixture with air.Conditions to avoidHeat, flames and sparks. Extremes of temperature and direct sunlight.Materials to avoidStrong oxidizing agentsHazardous decomposition productsHazardous decomposition products formed under fire conditions. - Carbon oxidesOther decomposition products - no data available11. TOXICOLOGICAL INFORMATIONAcute toxicityOral LD50LD50Oral - rat - 8,038 mg/kgInhalation LC50LC50Inhalation - rat - 1 h - 20000 ppmDermal LD50LC50Dermal - rabbit - 4,000 mg/kgOther information on acute toxicityno data availableSkin corrosion/irritationSkin - rabbit - Mild skin irritationSerious eye damage/eye irritationEyes - rabbit - Severe eye irritationRespiratory or skin sensitizationno data availableGerm cell mutagenicityno data availableCarcinogenicityIARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.NTP: No component of this product present at levels greater than or equal to 0.1% is identified as aknown or anticipated carcinogen by NTP.OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.Reproductive toxicityno data availableTeratogenicityno data availableSpecific target organ toxicity - single exposure (Globally Harmonized System)May cause drowsiness or dizziness.Specific target organ toxicity - repeated exposure (Globally Harmonized System)no data availableAspiration hazardno data availablePotential health effectsInhalation May be harmful if inhaled. Causes respiratory tract irritation.Vapours may causedrowsiness and dizziness.Ingestion May be harmful if swallowed.Skin May be harmful if absorbed through skin. Causes skin irritation.Eyes Causes eye irritation.Signs and Symptoms of ExposureCentral nervous system depression, prolonged or repeated exposure can cause:, narcosis, Skin irritation Synergistic effectsno data availableAdditional InformationRTECS: UH822500012. ECOLOGICAL INFORMATIONToxicityToxicity to fish LC50 - Pimephales promelas (fathead minnow) - 1,000 mg/l - 96 hToxicity to daphniaEC50 - Daphnia magna (Water flea) - 3,642 mg/l - 48 hand other aquaticinvertebratesPersistence and degradabilityBiodegradabilityBioaccumulative potentialno data availableMobility in soilno data availablePBT and vPvB assessmentno data availableOther adverse effectsno data available13. DISPOSAL CONSIDERATIONSProductBurn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.Contaminated packagingDispose of as unused product.14. TRANSPORT INFORMATIONDOT (US)UN number:1274 Class: 3 Packing group: IIProper shipping name: n-PropanolMarine Pollutant: NoPoison Inhalation Hazard: NoIMDGUN number: 1274 Class: 3 Packing group: II EMS-No: F-E, S-DProper shipping name: n-PROPANOLMarine Pollutant: NoIATAUN number:1274 Class: 3 Packing group: IIProper shipping name: n-Propanol15. REGULATORY INFORMATIONOSHA HazardsFlammable liquid, Target Organ Effect, IrritantSARA 302 ComponentsSARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 ComponentsSARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312HazardsFire Hazard, Acute Health Hazard, Chronic Health HazardMassachusetts Right To Know Componentsn-Propanol CAS-No.71-23-8Revision Date1993-04-24Pennsylvania Right To Know Componentsn-Propanol CAS-No.71-23-8Revision Date1993-04-24New Jersey Right To Know Componentsn-Propanol CAS-No.71-23-8Revision Date1993-04-24California Prop. 65 ComponentsThis product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.16. OTHER INFORMATIONFurther informationCopyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to theproduct with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.。
475150-69-7_BAN ORL 24相关参数MedBio
192322-50-2
50mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12697
CRF (human, rat)
CRF (human, rat)
86784-80-7
5mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED13424
MED12760
Neurotensin
Neurotensin
39379-15-2
20mg
≥98%
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12718
RS 100329 hydrochloride
RS 100329 hydrochloride
1215654-26-4
50mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12752
GRP (human)
GRP (human)
93755-85-2
1mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12866
SB 328437
SB 328437
247580-43-4
10mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
安捷伦产品目录
15
Real-Time PCR
16
Mx3000P QPCR System
17
Brilliant III Ultra-Fast SYBR Green QPCR and QRT-PCR Reagents
18
Brilliant III Ultra-Fast QPCR and QRT-PCR Reagents
Agilent / STRATAGENE
Agilent website: /genomics
Welgene | Agilent Stratagene
威健股份有限公司 | Stratagene 總代理
Table of Content
Table of Contents
/ XL1-Red Competent Cells SoloPack Gold Supercompetent Cells
/ TK Competent Cells Specialty Cells
/ Classic Cells / Fine Chemicals For Competent Cells
適用於 UNG 去汙染或 bisulphite
sequencing
適用於 TA Cloning
最高敏感性
取代傳統 Taq 的好選擇
-
2
威健股份有限公司 | Stratagene 總代理
PCR Enzyme & Instrument
Agilent SureCycler 8800
市場上領先的 cycling 速度和 sample 體積 10 ～ 100 μL 簡易快速可以選擇 96 well 和 384 well 操作盤 優秀的溫控設備讓各個 well 都能保持溫度的穩定 七吋的高解析度觸控螢幕讓操作上更為簡便 可以透過網路遠端操控儀器及監控儀器 Agilent 專業的技術支援可以幫助您應對各種 PCR 的問題
CAS32619-42-4_Oleuropein_MedBio合成方法
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED16126
Ginsenoside Rk1
Ginsenoside Rk1
494753-69-4
20mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED16434
JolkinolideB
JolkinolideB
37905-08-1
CAS
1、产品物理参数：
常用名
橄榄苦甙
英文名
Oleuropein
CAS号
32619-42-4
分子量
540.514
密度
1.5±0.1 g/cm3
沸点
772.9±60.0 °C at 760 mmHg
分子式
C25H32O13
熔点
89-90ºC
闪点
257.0±26.4 °C
2、技术资料：
体外研究
芳香化酶是一种细胞色素P450酶，是乳腺癌治疗的重要药物靶点[2]。
CAS
包装
纯度
MedBio
MED16230
Gypenoside XLIX
Gypenoside XLIX
10mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
etrandrine
Tetrandrine
518-34-3
10mM (in 1mL DMSO)
≥98%
品牌
货号
中文名称
20mg
≥98%
品牌
微流控芯片技术及质谱技术用于细菌耐药性检测及耐药机制研究
Journal of China Pharmaceutical University 2023，54（6）：695 - 705学 报微流控芯片技术及质谱技术用于细菌耐药性检测及耐药机制研究张冬雪，乔亮*（复旦大学化学系，复旦大学生物医学研究院，上海 200433）摘 要 细菌耐药性严重影响全球公共卫生安全。
抗生素错用和滥用不仅没有达到治疗细菌感染性疾病的效果，反而会刺激细菌发生DNA损伤修复反应（SOS反应），加剧细菌耐药性的进化和耐药菌的传播。
本文聚焦于耐药菌，简明介绍细菌耐药性与SOS反应，系统概述了质谱技术、微流控技术及其联用技术在细菌检测及细菌耐药机制研究中的应用。
本文为细菌耐药性相关的药物靶点挖掘及新药开发提供理论参考，以期发展细菌耐药性快速检测新方法和抑菌新方法，推动临床细菌感染性疾病的诊断与治疗。
关键词细菌耐药；耐药机制；微流控技术；质谱检测；组学分析中图分类号O65；R318 文献标志码 A 文章编号1000 -5048（2023）06 -0695 -11doi：10.11665/j.issn.1000 -5048.2023060203引用本文张冬雪，乔亮.微流控芯片技术及质谱技术用于细菌耐药性检测及耐药机制研究［J］.中国药科大学学报，2023，54（6）：695–705.Cite this article as：ZHANG Dongxue，QIAO Liang. Microfluidic chip and mass spectrometry-based detection of bacterial antimicrobial resis⁃tance and study of antimicrobial resistance mechanism［J］.J China Pharm Univ，2023，54（6）：695–705.Microfluidic chip and mass spectrometry-based detection of bacterial antimi⁃crobial resistance and study of antimicrobial resistance mechanism ZHANG Dongxue, QIAO Liang*Department of Chemistry, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, ChinaAbstract Bacterial antimicrobial resistance (AMR) is a globally serious problem that threatens public health security.Misuse and abuse of antibiotics cannot achieve the effect of treating bacterial infectious diseases, but will trigger the SOS response of bacteria, exacerbating the evolution of bacterial AMR and the spread of resistant bacteria.This article focuses on antibiotic-resistant bacteria, briefly introduces the pathogenesis of bacterial AMR and SOS response, and systematically summarizes the determination and mechanism study of bacterial AMR based on microfluidics and mass spectrometry.This article provides theoretical basis for AMR-related drug target mining and new drug development, aiming to develop new methods for rapid detection of bacterial AMR and new methods for bacteria inhibition, and promote the diagnosis and treatment of clinical bacteria infectious diseases. Key words bacterial antimicrobial resistance; mechanism of antimicrobial resistance; microfluidics; mass spec⁃trometry detection; omics analysisThis study was supported by China Postdoctoral Science Foundation (No.2022M720806)细菌是最常见的病原微生物之一，是引起大部分感染性疾病的重要原因。
cas334-49-6_(E)-2-Decenoic acid_MedBio_物理参数
None
25 units
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12157
Tanaproget
Tanaproget
304853-42-7
5mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12140
Andarine
Andarine
401900-40-1
10mM (in 1mL DMSO)
≥98%
MED12156
Sobetirome
Sobetirome
211110-63-3
50mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12290
8-Prenylnaringenin
8-Prenylnaringenin
53846-50-7
10mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12272
Estropipate
Estropipate
7280-37-7
50mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12201
OICR-9429_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :OICR-9429Catalog No. :HY-16993CAS No. :1801787-56-31.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4),H302Acute aquatic toxicity (Category 1),H400Chronic aquatic toxicity (Category 1),H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word No data availableHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effects.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose of contents/ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:OICR9429; OICR 9429Formula:C29H32F3N5O3Molecular Weight:555.59CAS No. :1801787-56-34. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGUN number: 3077Class: 9Packing group: IIIEMS-No: F-A, S-FProper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.Marine pollutant: Marine pollutant.IATAUN number: 3077Class: 9Packing group: IIIProper shipping name: Environmentally hazardous substance, solid, n.o.s.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
Vildagliptin_274901-16-5_DataSheet_MedChemExpress
Product Name:Vildagliptin CAS No.:274901-16-5Cat No :HY-14291Product Data SheetCat. No.:HY 14291MWt:303.40Formula:C17H25N3O2Purity :>98%25°C:DMSOSolubility:Mechanisms:Biological Activity:Pathways:Metabolism/Protease; Target:DPP425C: DMSODescription:IC50 Value: 2-3 nM[1]Vildagliptin (previously identified as LAF237, trade names Zomelis, Galvus) is an oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. vildagliptin inhibits DPP-4 with high specificity relative to other similar peptidases where itsIC50 exceeds 200 ?mol/L.in vitro: Vildagliptin is an N-substituted glycyl-2-cyanopyrrolidine (figure 2). It is a potent competitive and reversible inhibitor of human and rodent DPP-4 in vitro, with a median inhibitory concentration (IC50)~23nmol/L Importantly vildagliptin inhibits DPP 4with high specificity relative to other References:[1]. Villhauer EB, Brinkman JA, Naderi GB et al. 1-[[(3-hydroxy-1-adamantyl) amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor withantihyperglycemic properties. J Med Chem 2003;46:2774-89.[2]H YL K l t ki K Zh Y Ph ki ti f ild li ti i ti t ith i d (IC50) ~2-3 nmol/L. Importantly, vildagliptin inhibits DPP-4 with high specificity relative to othersimilar peptidases where its IC50 exceeds 200 ?mol/L [1].in vivo: Compared to age-, gender-, BMI-matched subjects with normal renal function, the mean AUC of vildagliptin after 14 days in patients with mild, mo...[2]. He YL, Kulmatycki K, Zhang Y, Pharmacokinetics of vildagliptin in patients with varying degreesof renal impairment. Int J Clin Pharmacol Ther. 2013 Jun 19.[3]. ?vila Dde L, Araújo GR, Silva M, Vildagliptin ameliorates oxidative stress and pancreatic betacell destruction in type 1 diabetic rats. Arch Med Res. 2013 Apr;44(3):194-202.Caution: Not fully tested. For research purposes onlyMedchemexpress LLC18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AE m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c om。
OICR-9429_CAS号1801787-56-3_M8475说明书_AbMole中国
分子量555.59溶解性（25°C ）DMSO 分子式C H F N O Water CAS 号1801787-56-3Ethanol储存条件3年 -20°C 粉末状生物活性OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 thatpotently binds to WDR5. OICR-9429 inhibits the interaction of WDR5 with MLL1 and RbBP5 in cells. For full characterization details, please see OICR-9429on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit /sgc不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA 指南）小鼠大鼠兔豚鼠仓鼠狗重量 (kg)0.020.15 1.80.40.0810体表面积 (m )0.0070.0250.150.050.020.5K 系数36128520动物 A (mg/kg) = 动物 B (mg/kg) ×动物 B 的K 系数动物 A 的K 系数例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的K 系数（3），再除以大鼠的K 系数（6），得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg 。
CHEMLOK 459X 产品说明书
USA SAFETY DATA SHEET300000002744 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATIONProduct name:CHEMLOK 459XProduct Use/Class:Primer for AdhesiveLORD Corporation 111 LORD Drive Cary, NC 27511-7923 USATelephone: 814 868-3180Non-Transportation Emergency: 814 763-2345 Chemtrec 24 Hr Transportation Emergency No. 800 424-9300 (Outside Continental U.S. 703 527-3887)EFFECTIVE DATE : 11/23/20202. HAZARDS IDENTIFICATIONGHS CLASSIFICATION :Flammable liquids Category 3 Skin corrosion/irritation Category 2 Serious eye damage/eye irritation Category 2A Carcinogenicity Category 2 Reproductive toxicity Category 2Specific target organ systemic toxicity (single exposure) Category 1 Central nervous system, Kidney, Liver, Respiratory systemSpecific target organ systemic toxicity (single exposure) Category 3 Specific target organ systemic toxicity (repeated exposure) Category 1 Nervous system, Respiratory system Specific target organ systemic toxicity (repeated exposure) Category 2 Ears Aspiration hazard Category 1Hazardous to the aquatic environment - acute hazard Category 2GHS LABEL ELEMENTS : Symbol(s)Signal WordD ANGERHazard StatementsFlammable liquid and vapor. Causes skin irritation.Causes serious eye irritation. Suspected of causing cancer.Suspected of damaging fertility or the unborn child. May cause harm to breast -fed children. Causes damage to organs.(Central nervous system, Kidney, Liver, Respiratory system ) May cause drowsiness or dizziness. May cause respiratory irritation.Causes damage to organs through prolonged or repeated exposure.(Nervous system, Respiratory system ) May cause damage to organs through prolonged or repeated exposure.(Ears ) May be fatal if swallowed and enters airways. Toxic to aquatic life.Precautionary StatementsPrevention- No smoking.Keep away from heat/sparks/open flames/hot surfaces.Ground/Bond container and receiving equipment.Use explosion-proof electrical/venti lating/lighting equipment.Use only non-sparking tools.Take precautionary measures against static discharge.Obtain special instructions before use.Do not handle until all safety precautions have been read and understood.e clothing/eye protection/face protection.Wear protective gloves/protectivUse personal protective equipment as required.Do not breathe dust/fume/gas/mist/vapors/spray.Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Use only outdoors or in a well-ven tilated area.Avoid release to the environment.ResponseIn case of fire: refer to section 5 of SDS for extinguishing media.Call a POISON CENTER or doctor/physician if you feel unwell.IF exposed: Call a POISON CENTER or doctor/physician.Specific treatm ent (see supplemental first aid instructions on this label).IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing..IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/showerIf skin irritation occurs: Get medical advice/attention.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.Continue rinsing.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.Do NOT induce vomiting.StorageStore in a well-ventilated place. Keep cool.Store in a well-ventilated place. Keep container tightly closed.Store locked up.Disposal:Dispose of contents/container in accordance with waste/disposal laws and regulations of your country or particular locality.Other Hazards:This product contains component(s) which have the following warnings; however based on the GHS classification criteria of your country or locale, the product mixture may be outside the respective category(s).Acute: Vapor harmful; may affect the brain or nervous system causing dizziness, headache or nausea. Possibleng a variety of symptoms such as dryness of the throat, tightness of irritation of the respiratory system can occur causithe chest, and shortness of breath. May cause central nervous system depression characterized by the followingiousness or coma. This product contains a progressive steps: headache, dizziness, staggering gait, confusion, unconscresidual amount of a chemical substance that may cause an allergic skin and/or respiratory reaction.May be harmful if swallowed. Ingestion is not an expected route of entry in industrial or commercial uses.-forming organs. Prolonged or Chronic: May affect the gastrointestinal system. May affect the blood and bloodrepeated contact may result in dermatitis. Ethylbenzene has been classified by IARC as a possible human carcinogenw clear evidence for carcinogenicity in animals.(Group 2B) and reported by NTP to showithheld.FIRST AID - EYE CONTACT: Flush eyes immediately with large amount of water for at least 15 minutes holding eyelids open while flushing. Get prompt medical attention.FIRST AID - SKIN CONTACT: Flush contaminated skin with large amounts of water while removing contaminated clothing. Wash affected skin areas with soap and water. Get medical attention if symptoms occur.FIRST AID - INHALATION: Move person to fresh air. Restore and support continued breathing. If breathing is difficult,ion.give oxygen. Get immediate medical attentFIRST AID - INGESTION: If swallowed, do not induce vomiting. Call a physician or poison control center immediatelyfor further instructions. Never give anything by mouth if victim is rapidly losing consciousness, unconscious or convulsing.SUITABLE EXTINGUISHI NG MEDIA: Carbon Dioxide, Dry Chemical, Foam, Water FogUNSUITABLE EXTINGUIS HING MEDIA: Not determined for this product.SPECIFIC HAZARDS POSSIBLY ARISING FROM T HE CHEMICAL: Flammable liquid and vapor. Keep containers tightly closed. Isolate from heat, electrical equipment, sparks, open flame, and other sources of ignition. Closed containersners cool. During a fire, irritatingmay rupture when exposed to extreme heat. Use water spray to keep fire exposed contaiand/or toxic gases and particulate may be generated by thermal decomposition or combustion.SPECIAL PROTECTIVE E QUIPMENT AND PRECAUT IONS FOR FIRE-FIGHTE RS: Wear full firefightingprotective clothing, including self-contained breathing apparatus (SCBA).If water isWater spray may be ineffective.used, fog nozzles are preferable.PERSONAL PRECAUTIONS, PROTECTIV E EQUIPMENT AND EMER GENCY PROCEDURES: Remove all.sources of ignition (flame, hot surfaces, and electrical, static or frictional sparks). Avoid contact. Avoid breathing vapors Use self-contained breathing equipment.ENVIRONMENTAL PREC AUTIONS: Do not contaminate bodies of water, waterways, or ditches, with chemical or used container.METHODS AND MATERIAL S FOR CONTAINMENT AN D CLEANUP: Keep non-essential personnel a safeorities if necessary. Avoid contact. Before attempting cleanup, refer distance away from the spill area. Notify appropriate auth-to hazard caution information in other sections of the SDS form. Contain and remove with inert absorbent material and non sparking tools.HANDLING: Keep closure tight and container upright to prevent leakage. Ground and bond containers when transferring material. Avoid skin and eye contact. Wash thoroughly after handling. Avoid breathing of vapor or spray mists. Do not-used. Use withhandle until all safety precautions have been read and understood. Empty containers should not be readequate ventilation. Because empty containers may retain product residue and flammable vapors, keep away from heat, puncture or weld on or near the empty container. Do not smoke where this product is used or sparks and flame; do not cut,stored.-ventilated areas. Do not puncture, drag, STORAGE: Do not store or use near heat, sparks, or open flame. Store only in welltainer closed when not in use. Refer to OSHA 29CFR Part 1910.106 "Flammable andor slide container. Keep conCombustible Liquids" for specific storage requirements.INCOMPATIBILITY: Strong oxidizers, acids, bases, water.Engineering controls: Sufficient ventilation in pattern and volume should be provided in order to maintain airposure limits. Caution: Solvent vapors are heavier than air and collect in lower contaminant levels below recommended ex-proof equipment) should be provided to prevent flammable levels of the work area. Sufficient ventilation (using explosionvapor/air mixtures from accumulating.PERSONAL PROTECTION MEASURES/EQU IPMENT:RESPIRATORY PROTECTION: Use a NIOSH approved chemical/mechanical filter respirator designed toremove a combination of particulates and organic vapor if occupational limits are exceeded. For emergencysituations, confined sp ace use, or other conditions where exposure limits may be greatly exceeded, use an approved air-supplied respirator. For respirator use observe OSHA regulations (29CFR 1910.134) or use in accordance witharticular locality.applicable laws and regulations of your country or pSKIN PROTECTION: Use neoprene, nitrile, or rubber gloves to prevent skin contact.EYE PROTECTION: Use safety eyewear including safety glasses with side shields and chemical goggles where splashing may occur.OTHER PROTECTIVE EQUIPMENT: Use disposable or impervious clothing if work clothing contamination is likely. Remove and wash contaminated clothing before reuse.HYGIENIC PRACTICES: Wash hands before eating, smoking, or using toilet facility. Do not smoke in anyche mical handling or storage area. Food or beverages should not be consumed anywhere this product is handled or stored. Wash thoroughly after handling.Typical values, not to be used for specification purposes.ODOR: Solvent VAPOR PRESSURE:N.D.APPEARANCE: Clear VAPOR DENSITY:Heavier than AirPHYSICAL STATE:Liquid LOWER EXPLOSIVE LIMIT: 1 %(V)UPPER EXPLOSIVE LIMIT:7 %(V)FLASH POINT: 81 °F, 27 °C SetaflashClosed CupBOILING RANGE: 136 - 141 °C EVAPORATION RATE:Not Applicable AUTOIGNITION TEMPERA TURE:N.D.DENSITY:0.85 g/cm3 (7.08 lb/gal)DECOMPOSITION TEMPER ATURE:N.D. VISCOSITY, DYNAMIC:≥10 mPa.s @ 25 °C ODOR THRESHOLD:N.D.VISCOSITY, KINEMATIC: ≥12 mm2/s@ 25 °CSOLUBILITY IN H2O:Insoluble VOLATILE BY WEIGHT:96.50 %pH: N.A.VOLATILE BY VOLUME:97.18 %FREEZE POINT:N.D. VOC CALCULATED: 6.83 lb/gal, 819 g/lN.D. METHOD 24: 7.03 lb/gallon COEFFICIENT OF WATER/OILDISTRIBUTION:LEGEND: N.A. - Not Applicable, N.E. - Not Established, N.D. - Not DeterminedHAZARDOUS POLYMERIZATION: Hazardous polymerization will not occur under normal conditions.STABILITY: Product is stable under normal storage conditions.CONDITIONS TO AVOID: High temperatures. Sources of ignition.INCOMPATIBILITY: Strong oxidizers, acids, bases, water.HAZARDOUS DECOMPOSITION PRODUCTS: Carbon dioxide, carbon monoxide, chlorine, hydrogen chloride, PhosgeneEXPOSURE PATH: Refer to section 2 of this SDS.SYMPTOMS:Refer to section 2 of this SDS.TOXICITY MEASURES:Germ cell mutagenicity: No classification proposedCarcinogenicity: Category 2- Suspected of causing cancer.Components contributing to classification:Ethyl benzene.-Reproductive toxicity: Category 2- Suspected of damaging fertility or the unborn child. May cause harm to breast fed children.Components contributing to classification:Xylene. Ethyl benzene. Toluene.PERSISTENCE AND DEGRADABILITY:Not determined for this product.BIOACCUMULATIVE: Not determined for this product.MOBILITY IN SOIL: Not determined for this product.OTHER ADVERSE EFFECTS: Not determined for this product.DISPOSAL METHOD: Disposal should be done in accordance with Federal (40CFR Part 261), state and localIf waste is determined to be hazardous, use licensed hazardous waste transporter and environmental control regulations.disposal facility.US DOT RoadProper Shipping Name: AdhesivesHazard Class: 3SECONDARY HAZARD: NoneUN/NA Number: 1133Packing Group: IIIEmergency Response Guide Number: 128IATA CargoPROPER SHIPPING NAME: AdhesivesHazard Class: 3HAZARD CLASS: NoneUN NUMBER: 1133PACKING GROUP: IIIEMS: 3LIMDGPROPER SHIPPING NAME: AdhesivesHazard Class: 3HAZARD CLASS: NoneUN NUMBER: 1133PACKING GROUP: IIIEMS: F-E-bulk shipments. It does not address regulatory variations due toThe listed transportation classification applies to nonchanges in package size, mode of shipment or other regulatory descriptors. For the most accurate shipping information, refer to your t ransportation/compliance department.U.S. FEDERAL REGULATIONS: AS FOLLOWS:SARA SECTION 313This product contains the following substances subject to the reporting requirements of Section 313 of Title III of the:Superfund Amendment and Reauthorization Act of 1986 and 40 CFR part 372.Chemical Name CAS Number Weight % Less ThanXylene1330-20-780.0%Ethyl benzene100-41-420.0%TOXIC SUBSTANCES CONTROL ACT:INVENTORY STATUSThe chemical substances in this product are on the TSCA Section 8 Inventory.EXPORT NOTIFICATIONThis product contains the following chemical substances subject to the reporting requirements of TSCA 12(B) if:exported from the United StatesNoneUnder HazCom 2012 it is optional to continue using the HMIS rating system. It is important to ensure employees have been trained to recognize the different numeric ratings associated with the HazCom 2012 and HMIS schemes.HMIS RATINGS - HEALTH: 2* FLAMMABILITY: 3 PHYSICAL HAZARD: 0* - Indicates a chronic hazard; see Section 2Revision: Section 1Effective Date: 11/23/2020The information contained herein is, to the best of our knowledge and belief, accurate. However, since the conditions of handling and use are beyond our control, we make no guarantee of results, and assume no liability for damages incurred byuse of this material. It is the responsibility of the user to comply with all applicable federal, state and local laws and regulations.。
98672-91-4_SQ 29,548_基本说明_MedBio
1216468-02-8
50mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED13113
PSB 36
PSB 36
524944-72-7
10mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED13031
AM 281
AM 281
202463-68-1
50mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED13026
Senktide
Senktide
106128-89-6
5mg
≥98%
分子式
C21H29N3O4
熔点
无资料
闪点
无资料
2、SQ-29548同类产品列表：
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED13450
AH 23848 (calcium salt)
AH 23848 (calcium salt)
81496-19-7
1mg
≥98%
品牌
货号
中文名称
英文名称
CAS
98672-91-4
1、SQ-29548物理参数：
常用名
1S-[1Α,2Β(5Z),3Β,4Α]]-7-[3-[2-(苯氨基甲酰基)肼基甲基]-7-氧代双环[2.2.1]庚-2-基]-5-庚烯酸
MSDS-Maltodextrin-9924569
Section 4: First Aid Measures
Eye Contact: Check for and remove any contact lenses. Do not use an eye ointment. Seek medical attention. Skin Contact: After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing before reusing.
p. 1
Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention. Serious Inhalation: Not available. Ingestion: Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention. Serious Ingestion: Not available.
Chemlok 8009和8009B水溶液基础剂技术数据表说明书
Chemlok® 8009 and 8009B Primers Technical Data SheetChemlok® 8009 and 8009B primers are water-based primers that bond elastomers to metals and other substrates when used with Chemlok water-based or solvent-based covercoat adhesives. These primers are composed of a mixture of dispersed mineral fillers, organic compounds, resins and polymer latices in an aqueous medium. Features and Benefits:Environmentally Preferred – provides low VOC and HAP for reduced emissions, allowing for safer work environment and regulatory compliance.Versatile – functions as an effective primer for many materials such as steel, phosphated steel, nylon, aluminum and brass.Environmentally Resistant – preferred water-based Chemlok primer for glycol resistance; provides excellent resistance to water, salt spray, oil and heat.Durable – maintains excellent metal adhesion under flexing and high-stress conditions.Excellent Appearance – provides a smooth coating for spray applications.Easy to Use – easily redispersed within 5 to 15 minutes of stirring; imparts little or no settling; ready to use directly out of the container without dilution.Application:Surface Preparation – Thoroughly clean metal surfaces prior to application. Remove protective oils, cutting oilsand greases by solvent degreasing or alkaline cleaning. Remove rust, scale or oxide coatings by suitable chemical or mechanical cleaning methods.For further detailed information on surface preparation of specific substrates, refer to Chemlok Adhesives application guide.Mixing – Thoroughly mix primer before using to disperse any soft settling which may have occurred during storage. Do not shake. To prevent foaming, mechanical mixing should not exceed 30 rpm. The addition of anti-foaming agents is not recommended.In most cases, dilution is not required. Deionized water is suggested if dilution is necessary. Add water gradually while stirring either by hand or by using another low-shear mixing method.Applying – Preheat substrates to 55-75°C (131-167°F) prior to spray application of primer. This heat and spray method prevents runs and sags and gives a dry coating ready for covercoat application. Use contaminant-free air for spraying. All spray equipment, including tanks, fixtures, pressure pots, hoses, guns and nozzles, should be stainless steel or plastic. Dry film thickness of Chemlok 8009 or 8009B primer shouldbe 5.1-10.2 micron (0.2-0.4 mil).Parker LORDEngineered Materials Group 111 LORD DriveCary, NC 27511-7923USAphone +1 877 ASK LORD (275 5673)Values stated in this document represent typical values as not all tests are run on each lot of material produced. For formalized product specifications for specific product end uses, contact the Customer Support Center.Information provided herein is based upon tests believed to be reliable. In as much as Parker LORD has no control over the manner in which others may use this information, it does not guarantee the results to be obtained. In addition, Parker LORD does not guarantee the performance of the product or the results obtained from the use of the product or this information where the product has been repackaged by any third party, including but not limited to any product end-user. Nor does the company make any express or implied warranty of merchantability or fitness for a particular purpose concerning the effects or results of such use.WARNING — USER RESPONSIBILITY . FAILURE OR IMPROPER SELECTION OR IMPROPER USE OF THE PRODUCTS DESCRIBED HEREIN OR RELATED ITEMS CAN CAUSE DEATH, PERSONAL INJURY AND PROPERTY DAMAGE.This document and other information from Parker-Hannifin Corporation, its subsidiaries and authorized distributors provide product or system options for further investigation by users having technical expertise.The user, through its own analysis and testing, is solely responsible for making the final selection of the system and components and assuring that all performance, endurance, maintenance, safety and warning requirements of the application are met. The user must analyze all aspects of the application, follow applicable industry standards, and follow the information concerning the product in the current product catalog and in any other materials provided from Parker or its subsidiaries or authorized distributors.To the extent that Parker or its subsidiaries or authorized distributors provide component or system options based upon data or specifications provided by the user, the user is responsible for determining that such data and specifications are suitable and sufficient for all applications and reasonably foreseeable uses of the components or systems.©2021 Parker Hannifin - All Rights ReservedInformation and specifications subject to change without notice and without liability therefor. Trademarks used herein are the property of their respective owners.Chemlok 8009 and 8009B Primers — Technical Data SheetOD DS4074 04/21 Rev.3Drying – If no preheat is employed, parts will dry in 30-60 minutes at room temperature. Allow coated parts to dry at least 60 minutes at room temperature before applying Chemlok covercoat adhesive.When used in combination with Chemlok covercoatadhesives, Chemlok 8009 or 8009B primer can be used to bond rubber by compression, transfer and injection molding procedures.Cleanup – Use soap and water to remove wet primer. Dried primer is not water-soluble and must be removed with a ketone-type solvent.Shelf Life/Storage:Shelf life is six months from date of shipment when stored by the recipient at 21-27°C (70-80°F) in original, unopened container. Do not freeze product. Storage below 4°C (40°F) may be detrimental to the product’s properties.Cautionary Information:Before using this or any Parker LORD product, refer to the Safety Data Sheet (SDS) and label for safe use and handling instructions.For industrial/commercial use only. Must be applied by trained personnel only. Not to be used in household applications. Not for consumer use.。
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Inhibitors, Agonists, Screening Libraries
Data Sheet
BIOLOGICAL ACTIVITY:
OICR–9429 is a novel small–molecule antagonist of the Wdr5–MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation .
target: Wdr5
IC 50: 5 uM
In vitro: OICR–9429 inhibit proliferation and induce differentiation in p30–expressing human AML cells. OICR–9429 cause a significant decrease in viability in the majority of patient cells with mutations in the N–terminal part of the CEBPA gene. OICR–9429 displays
exquisite cellular selectivity and specificity in disrupting critical protein–protein interactions between WDR5. [1] reduce the viability of primary human AML cells with N–terminal C/EBPα mutations by about 50% (mean value, n = 8) at 5 μM
[2]
In vivo:The reference for OICR–9429 to mice (female NOD–SCID) is 3 mg/kg.
References:
[1]. Grebien F et al. Pharmacological targeting of the Wdr5–MLL interaction in C/EBPα N–terminal leukemia. Nat Chem Biol. 2015 Aug;11(8):571–8.
[2]. Getlik M et al. Structure–Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat–Containing Protein 5 (WDR5) and Mixed–Lineage Leukemia 1 (MLL1). J Med Chem. 2016 Mar 24;59(6):2478–96.
Product Name:
OICR–9429Cat. No.:
HY-16993CAS No.:
1801787-56-3Molecular Formula:
C 29H 32F 3N 5O 3Molecular Weight:
555.59Target:
Histone Methyltransferase Pathway:
Epigenetics Solubility:
DMSO: ≥ 32 mg/mL
Caution: Product has not been fully validated for medical applications. For research use only.
Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@ Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。