Packaging of immunostimulatory substances into vir
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专利名称：Packaging of immunostimulatory substances into virus-like particles: method of
preparation and use
发明人：INDULIS CIELENS,EDWIN
MEIJERINK,MARTIN F. BACHMANN,ALAIN
TISSOT,PATRICK MAURER,TAZIO
STORNI,REGINA RENHOFA,PAUL
PUMPENS,GERAD LIPOWSKY,KATRIN
SCHWARZ
申请号：AU2009200115
申请日：20090109
公开号：AU2009200115A1
公开日：
20090205
专利内容由知识产权出版社提供
摘要：The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG- VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Thl type. Antigens attached to CpG-loaded VLPs may therefore be ... SIMILAR ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
申请人：CYTOS BIOTECHNOLOGY AG 更多信息请下载全文后查看。