MRSE-3-5CKXPC中文资料
C8051F330中文资料
（2）IO: IO 信号输出控制程序。 （3）Keyled: 键盘读取及 LED 数码管显示程序。 （4）IIC_EEPROM: IIC 接口 EEPROM(AT24C02A, 容量256字节)读写程序。 （5）IIC_RTC: IIC 接口实时时钟(PCF8563)读写程序。 （6）PWM: PWM 信号输出控制程序。 （7）RS232: RS232串行数据通信程序。 （8）ADC_Uart: ADC 采样转换及计算程序。 （9）ADC_display: ADC 采样转换及数据处理数码管显示。 （10）DAC: DAC 转换及计算程序。 （11）Timer: Timer2、Timer3计时程序。 （12）INT0: 外部中断0测试程序。 （13）bootloader: 如果 C8051F330内部 bootloader 程序不慎被擦除，可应用 C8051F 网络生产的 EC3将 bootloader.hex 程序下载到芯片中。
时钟源 − 两个内部振荡器：
24.5MHz，±2%的精度，可支持无晶体 UART 操作 80/40/20/10 kHz 低频率、低功耗振荡器 − 外部振荡器：晶体、RC、C、或外部时钟 − 可在运行中切换时钟源，适用于节电方式 封装：20脚 MLP
性能最好，价格最低的 C8051F 单片机学习板 c8051f 单片机应用解析之 c8051f330 内容：
3．本学习板主要特点 （1）选择与 MCS51单片机兼容高性能的混合信号处理器 C8051F330作为控制芯片。 （2）可以不使用仿真器（EC3）就可以进行软件下载调试，节约开发费用。 （3）编写了完善的软件例程，基本覆盖了 C8051F330单片机的所有功能。
4．学习板软件例程 （1）Delay: 软件延时程序，利用软件进行延时操作。
3_种常用碳青霉烯类抗生素血药浓度UPLC-MS
3种常用碳青霉烯类抗生素血药浓度UPLC-MS/MS检测方法的建立Δ秦怡1＊，张瑞霞2，吕雅瑶2，翁莉莉1，张弋2 #（1.天津医科大学一中心临床学院，天津 300192；2.天津市第一中心医院药学部，天津 300192）中图分类号 R917；R978.1文献标志码 A 文章编号 1001-0408（2024）03-0343-05DOI 10.6039/j.issn.1001-0408.2024.03.14摘要目的建立3种临床常用碳青霉烯类抗生素——厄他培南（ETP）、亚胺培南（IPM）、美罗培南（MEM）血药浓度检测的超高效液相色谱-质谱联用（UPLC-MS/MS）法。
方法血浆样品经甲醇沉淀蛋白后，以3种抗生素的稳定性同位素（ETP-D4、IPM-D4、MEM-D6）为内标，采用ACQUITY UPLC BEH C18（2.1 mm×50 mm，1.7μm）色谱柱分离；流动相为98%乙腈+2%水+0.1%甲酸和98%水+2%乙腈+0.1%甲酸，梯度洗脱；流速为0.3 mL/min；柱温为40 ℃；采用正离子、多反应监测模式进行扫描分析。
结果该方法专属性良好，在ETP、IPM、MEM 0.2～200、0.1～100、0.1～100μg/mL范围内线性良好（r2≥0.993），批内、批间精密度和准确度良好（RE均≤5.14%，RSD均≤11.15%），基质效应、提取回收率较一致（RSD≤12.99%）。
结论本实验建立了一种可以同时定量ETP、IPM、MEM血药浓度的UPLC-MS/MS法，该方法样品前处理简单、检测时间短、所需样品量少，可满足临床需求。
关键词碳青霉烯类抗生素；超高效液相色谱-质谱联用；血药浓度；厄他培南；亚胺培南；美罗培南Establishment of UPLC-MS/MS method for the determination of plasma concentration of three common carbapenem antibioticsQIN Yi1，ZHANG Ruixia2，LYU Yayao2，WENG Lili1，ZHANG Yi2（1. First Central Clinical College of Tianjin Medical University，Tianjin 300192，China；2. Dept. of Pharmacy，Tianjin First Central Clinical Hospital，Tianjin 300192， China）ABSTRACT OBJECTIVE To establish a UPLC-MS/MS method for the determination of plasma concentration of three carbapenem antibiotics，i.e. ertapenem （ETP），imipenem （IPM）and meropenem （MEM）.METHODS After protein precipitation with methanol，the plasma samples were separated by ACQUITY UPLC BEH C18column （2.1mm×50mm，1.7μm）using stable isotopes of three antibiotics （ETP-D4，IPM-D4，MEM-D6）as the internal standard. The mobile phases were 98%acetonitrile +2% water +0.1%formic acid and 98%water +2%acetonitrile +0.1%formic acid，by gradient elution. The flow rate was 0.3mL/min and the column temperature was 40 ℃. Scanning analysis was performed in the positive ion and multiple reaction monitoring mode. RESULTS The method had good specificity，good linearity （r2≥0.993）in the range of 0.2-200，0.1-100and 0.1-100μg/mL of ETP，IPM and MEM，and good intra-batch and inter-batch precision and accuracy （all RE≤5.14%，all RSD≤11.15%），the matrix effect and extraction recovery were consistent （RSD≤12.99%）. CONCLUSIONS This study establishes the UPLC-MS/MS method to simultaneously quantify the plasma concentration of ETP，IPM and MEM. The method has the advantages of simple pretreatment， short detection time and small sample quantity to meet clinical requirement.KEYWORDS carbapenem antibiotics； UPLC-MS/MS； plasma concentration； ertapenem； imipenem； meropenem碳青霉烯类抗生素具有抗菌谱广、抗菌活性强、耐药率低的特点，已成为治疗重症感染的主要选择。
赛多利斯过滤-中文目录
滤芯
赛多利斯滤芯产品—专为医药工业设计使用
在赛多利斯，我们销售给您的不仅 仅是一个滤芯，您同时也得到了全 面深入了解您需求的赛多利斯经验 丰富的过滤工程师，资深过滤专家 和销售代表提供的服务。只有在彻 底了解您的生产工艺后，我们才会 推荐给您一个相应的过滤系统。在 我们推荐的背后是80多年从事专业 过滤技术和从实验小试到生产规模 的应用支持经验。 赛多利斯遍及世界各地的销售代表 和客户服务机构，对客户进行有效 的支持。赛多利斯两个生产基地和 世界范围内的仓储机构更便于我们 随时响应您的需求。我们全球的技 术专家将为您提供全方位的支持服 务，帮助您维护和有效利用您的过 滤产品。 我们生产从深层预过滤器到终端过 滤器全范围的系列过滤产品，产品 规模从小型的圆片平板滤膜到囊式 滤器到大型的标准滤芯到MaxiCaps， 我们还生产与之配套使用的滤壳， 滤壳也包括从实验室，中试生产以 至大规模生产的系列产品，以适应 您的不同应用需求。 滤芯品种包括： ● 深层预过滤滤芯 ● 膜预过滤滤芯 ● 终端除菌膜过滤滤芯
品，以最大优化的过程设计使整个
过滤系统的流速和通透量最大化。 生产验证
制定工业新标准
为了验证生产过程中使用的过滤 产品，赛多利斯公司提供了全方
在我们"Plant 2001"的生产基地，我 们为应用在生物技术领域的产品制 定了一个新的质量标准。我们使用 顶级标准为指南，按照医药产品生
位的验证支持服务。赛多利斯公司 可以协助药品生产企业验证产品， 完成生产过程中与过滤产品使用相 关的验证。随着对药品生产管理的
膜预过滤滤器
生物液体中含有大量的超细颗粒， 它们可以迅速阻塞0.2 μm或孔径更 小的过滤膜。膜预过滤滤芯结合了 深层过滤介质和滤膜，能极大地提 高下游终端膜过滤滤芯的通透量， 使整个过滤系统的运行更为经济可 靠。 正确地选择预过滤器，深层预过滤 或膜预过滤，不仅降低过滤成本而 且能够极大提高终端滤芯的过滤效 率。这样，在增大过滤生产过程中 更换滤芯，以保证不间断过滤过 程。
EPA3545A(中文)
EPA方法3545A-1加压液体萃取(PFE)(2000年十一月,修订1A)应用范围1.是一种从土壤,粘土,沉积物,淤泥,固体废物中萃取水不溶或微溶的有机化合物的过程.方法用挥发温度(100-180度)和压力(1500-2000psi)来完成与索氏萃取相同回收率结果,更所用的溶剂更少,所花时间比索氏萃取明显减少.是一种商品化,自动萃取系统.2.方法应用于半挥发有机化合物,有机磷农药,有机氯农药,含氯除草剂,PCBs,PCDDs/PCDFs, 和柴油机范围有机物(DRO), 它些化合物可以用色谱进行分析.3.方法已经用于含250至12,500 µg/kg半挥发有机化合物,250至2500µg/kg有机磷农药, 5至250µg/kg有机氯农药, 50至5000µg/kg含氯除草剂,1至1400 µg/kgPCBs,1至2500 ng/kgPCDDs/PCDFs,和5至2000 mg/kgDRO.方法要点1.方法由空气干燥和碾磨的样品,或样品与无水硫酸钠或颗粒状的硅藻土混合.样品装载萃取池.含有样品的萃取池加热到萃取温度,加压到合适溶剂系统萃取5-10分钟.2.溶剂待加热之后冷却,经过滤后收集样品.萃取可以进行样品浓缩.适用的仪器1.美国戴安公司加速溶剂萃取仪(Dionex Accelerated Solvent Extractor®)或Supelco SFE-400带合适大小的萃取池,现有的池用于1-g,5-g, 10-g, 20-g和30-g样品. 池体应为不锈钢或其它可以耐高压(2000psi以上)材料制成.2.如采用其它系统,必须确证该系统对被测物和基体萃取足够有效.3.对样品进行的干燥装置,包括高温炉,干燥器,瓷坩埚或一次性铝坩埚.4.碾磨装置,使样品颗粒小于1 mm.5.分析天平,能够准确到.0.01g.6.收集瓶收集萃取物为40-mL或60-mL,预清洗好,瓶口带螺帽的聚四氟乙烯硅树脂隔膜(美国戴安公司Dionex 049459, 049460, 049461,049462或替代产品).7.过滤片 - 1.983-cm, 纤维素或玻璃纤维(美国戴安公司Dionex 049458或047017).8.池盖封盘(美国戴安公司Dionex 49454, 49455,或替代品).9.干燥,萃取及添加剂根据样品不同进行选择,不同的样品和基体萃取条件不同.分析条件(部分)采集的样品干燥,碾磨,称量后进行萃取1.半挥发物质,有机磷农药,有机氯农药,除草剂,PCBs炉温:100摄氏度压力:1500-2000 psi静置时间: 5 min (5-min 预热平衡之后)冲洗体积: 60%的池体积氮气清洁: 在150 psi下60 sec(对于大体积池清洁时间可以增加)静态循环次数: 12.PCDDs/PCDFs炉温: 150 - 175摄氏度压力: 1500 - 2000 psi静置时间: 5 -10 min (7-至8-min预平衡之后)冲洗体积: 60 - 75%的池体积氮气清洁: 150 psi下60 sec(对于大体积池清洁时间可以增加)静态环境次数: 2或33.DRO炉温: 175EC压力: 1500 - 2000 psi静置时间: 5 -10 min (7-至8-min预平衡之后)冲洗体积: 60 - 75%的池体积氮气清洁: 150 psi下60 sec(对于大体积池清洁时间可以增加)静态环境次数: 1方法的效能1.含氯农药和半挥发有机化合物三种不同土壤加标不同浓度的含氯农药,采用戴安公司的加速溶剂萃取和自动索氏萃取(EPA 方法8270和8081)比较,结果一致.2.有机磷农药和含氯除草剂三种不同土壤加标不同浓度的有机磷农药和含氯除草剂,戴安公司的加速溶剂萃取和索氏萃取(EPA方法8141和8151),结果一致.3.PCBs由NIST(标准参照物质,SRM 1939, River Sediment)土壤样品用戴安公司的加速溶剂萃取和自动索氏萃取(EPA方法8082),结果一致.4.PCDDs/PCDFs由相对高污染土壤样品(EC-2, National Water Research Institute,Burlington, Ontario, Canada), 和低含量沉积物样品(HS-2, National Research Council Institute of Marine Biosciences, Halifax, Nova Scotia, Canada)和不同产地的污染土壤,比较戴安公司的加速溶剂萃取和传统的索氏萃取,萃取物用高分辨质谱同位素稀释定量.与EPA方法8290一致.5.DRO三个不同的土壤类型和三种不同加标浓度,比较戴安公司的加速溶剂萃取和EPA方法8015,结果一致.。
Terminator 5′-Phosphate-Dependent Exonuclease 产品说明
ManualTerminator 5′-Phosphate-Dependent ExonucleaseF or Research Use Only. Not for use in diagnostic procedures.Contents1. Introduction (3)2. Product designations and kit components (3)3. Product specifications (3)4. General considerations (3)5. Standard procedure (5)6. Alternative procedure (5)7. Further support (7)1. IntroductionTerminator 5′-Phosphate-Dependent Exonuclease is a processive 5′→3′ exonuclease that digests RNA having a 5′ monophosphate. It does not digest RNA having a 5′-triphosphate, 5′-cap or 5′-hydroxyl group. These enzymatic properties make Terminator Exonuclease ideal for producing mRNA-enriched samples from both eukaryotic and prokaryotic total RNA preparations by selectively digesting the ribosomal RNA (rRNA).Terminator Exonuclease can be used to isolate eukaryotic mRNA substantially free of 18S and 28S rRNA without using an oligo(dT) matrix. Further, Terminator Exonuclease provides a simple andeffective method for purifying unprocessed, primary bacterial transcripts by removing large rRNA and other processed transcripts.Terminator Exonuclease will also digest single-stranded DNA (ssDNA) having a 5′-phosphate group. It does not digest ssDNA or dsDNA having a 5′-triphosphate or a 5′-hydroxyl group. Terminator Exonuclease is not inhibited by RNase inhibitors such as RNasin (Promega Corporation), Prime RNase Inhibitor (Eppendorf AG) or RiboGuard™ RNase Inhibitor.Terminator 5′-Phosphate-Dependent Exonuclease is available in a 40 unit size at a concentration of 1 U/µL. Two different Terminator 10X Reaction Buffers are also provided with the enzyme, each optimised for different applications.2. Product designations and kit componentsProductKit size Reagent description Catalogue number Part number Volume 3. Product specificationsStorage: Store only at -20 °C in a freezer without a defrost cycle.Storage buffer: Terminator Exonuclease is supplied in a 50% glycerol solution containing 50 mM Tris-HCl (pH 7.5), 0.1 M NaCl, 0.1 mM EDTA, 1 mM dithiothreitol and 0.1% Triton X-100.Unit definition: One unit digests 1 μg of rRNA substrate into acid-soluble nucleotides in 60 minutes at 30 °C under standard assay conditions.Quality control: Terminator Exonuclease is function-tested in a 50 µL reaction containing 50 mM Tris-HCl (pH 8.0), 2 mM MgCl 2, 100 mM NaCl, 20 μg rRNA and varying amounts of enzyme.Contaminating activity assays: Terminator Exonuclease is free of detectable contaminating endonuclease and non-5′-phosphate-dependent nuclease activities.4. General considerationsIntegrity of the RNA sample: The success of a Terminator Exonuclease reaction is strongly influenced by the quality of the total RNA sample used in the reaction. Therefore, it is important to confirm the purity and integrity of the RNA sample prior to beginning the reaction.RNA sample: The RNA sample to be treated with Terminator Exonuclease should be dissolved in RNase-free water prior to treatment.IMPORTANT: Do not dissolve the RNA sample in TE buffer (10 mM Tris-HCl [pH 7.5], 1 mM EDTA) or any other EDTA-containing buffer. EDTA concentrations as low as 1 mM will inhibit Terminator Exonuclease activity.Maintaining an RNase-free environment: Ribonuclease contamination is a significant concern for those working with RNA. The ubiquitous RNase A is a highly stable and active ribonuclease that can contaminate any lab environment and is present on human skin.Creating an RNase-free work environment and maintaining RNase-free solutions is critical for performing successful reactions. Therefore, we strongly recommend that the user:1) Autoclave all tubes and pipette tips that will be used in the reactions.2) Always wear gloves when handling samples containing RNA. Change gloves frequently especiallyafter touching potential sources of RNase contamination such as door knobs, pens, pencils and human skin.3) Always wear gloves when handling reaction components. Do not pick up the enzyme or buffer withan ungloved hand.4) Keep all components tightly sealed when not in use. Keep all tubes containing RNA tightly sealedduring the incubation steps.Buffer/protocol choice: Terminator 5′-Phosphate-Dependent Exonuclease is a processive 5′→3′ exonuclease that digests RNA that has a 5′ monophosphate. It does not digest RNA that has a5′-triphosphate, 5′-cap or 5′-hydroxyl group. However, on rare occasions, we have observed a secondary, non-5′-monophosphate-specific activity on 5′-triphosphate and 5′-hydroxyl RNAs. Because of this activity, two different 10X Reaction Buffers are provided with this kit. The Terminator 10X Reaction Buffer A and its affiliated protocol constitute the standard buffer and protocol. They have been optimised for maximum 5′-monophosphate RNA digestion (e.g., rRNA digestion). The Terminator 10X Reaction Buffer B and its affiliated protocol are provided as an alternate method that should only be used in the rare event that a specific RNA of interest is being degraded by a secondary non-5′-monophosphate-specific activity. Note, however, that less rRNA will be degraded with this buffer and protocol.NOTE: For best digestion, total input RNA must be of high quality (RNA Integrity Number of at least 8 when evaluated on an Agilent Bioanalyzer Model 2100).NOTE: Using the two different buffers in a 50:50 ratio will not produce a reaction condition with the benefits of each individual buffer and protocol.5. Standard procedureIMPORTANT: Two different reaction buffers and protocols are included with Terminator Exonuclease. Be sure to read Buffer/Protocol Choice (section above) to determine which protocol is appropriate for your intended use. Use one or the other. Do not mix buffers.This protocol uses the Terminator 10X Reaction Buffer A and has been optimised for maximum5′-monophosphate rRNA digestion (e.g., rRNA digestion). Buffer B may be used for very low-mass RNA samples.The RNA sample to be treated should be dissolved in RNase-free water. Do not dissolve the RNA sample in TE buffer.1. Gently mix and briefly centrifuge the Terminator 10X Reaction Buffer A prior to use.2. In a sterile (RNase-free) 0.2 mL or 0.5 mL tube, combine the following reaction components on ice:x μL RNase-free water2 µL Terminator 10X Reaction Buffer A0.5 µL RiboGuard RNase Inhibitory µL Total RNA Sample (200 ng-10 μg)1 μL Terminator Exonuclease (1 unit)20 μL Total reaction volume3. Incubate the reaction at 30 °C for 60 minutes in a thermocycler (with heated lid) or Water bath.4. Terminate the reaction by one of the two methods described in Section 6, Step 4.6. Alternative procedureIMPORTANT: Two different reaction buffers and protocols are included with Terminator Exonuclease. Be sure to read Buffer/Protocol Choice (section above) to determine which protocol is appropriate for your intended use.This protocol uses the Terminator 10X Reaction Buffer B and should only be used in the rare event that a specific RNA of interest is being degraded by a secondary non-5′-monophosphate-specific activity of the enzyme.NOTE: Less rRNA will be degraded with this buffer and protocol.The RNA sample to be treated should be dissolved in RNase-free Water. Do not dissolve the RNA sample in TE buffer.1. Gently mix and briefly centrifuge the Terminator 10X Reaction Buffer B prior to use.2. In a sterile (RNase-free) 0.2-mL or 0.5-mL tube, combine the following reaction components on ice:x μL RNase-free water2 µL Terminator 10X Reaction Buffer B0.5 µL RiboGuard RNase Inhibitory Total RNA Sample (1-2.5 μg)1 μL Terminator Exonuclease (1 unit)20 μL Total reaction volume3. Incubate the reaction at 42 °C for 30 minutes in a thermocycler (With heated lid) or Water bath.4. Terminate the reaction by one of the two methods described below:4a. Terminate the reaction by adding 1 µL of 100 mM EDTA (pH 8.0).Place the reaction on ice. Note that the enriched mRNA sample will now contain 5 mM EDTA (as well as tRNA, nucleotides and other small RNAs). It may be used directly for applications in which the EDTA will not be inhibitory. However, the high concentration of EDTA may interfere with some subsequent uses of the mRNA, such as RT-PCR. Therefore, it may be necessary to remove the excess EDTA by LiCl precipitation (see beloW), ethanol precipitation or use of anRNA purification column.4b. Terminate the reaction by phenol extraction and ethanol precipitation.1. Add RNase-free water to the reaction to a total volume of 200 µL. Extract once withbuffer-saturated phenol.2. Transfer the aqueous phase to a new RNase-free tube.3. Add 0.1 volume of 3 M sodium acetate and 2.5 volumes of ethanol to the aqueous phaseand mix thoroughly.4. Incubate on ice or at -20 °C for 30 minutes.5. Pellet the RNA by centrifugation in a microcentrifuge for 30 minutes at full speed at 4 °C.6. Carefully remove and discard the supernatant. Do not disturb the RNA pellet which containsthe mRNA.7. Wash the RNA pellet with 70% ethanol to remove residual salt. Resuspend the RNA pellet inRNase-free water or TE buffer.5. (Optional) Purify the enriched mRNA. If desired, the enriched mRNA can be purified from excessEDTA, tRNA, 5S rRNA and other small RNA species, by LiCl precipitation or by using a commercial RNA purification column.Lithium chloride precipitation should be performed only if the original reaction contains >2 μg of total RNA. If the amount of total RNA in the reaction was less than 2 μg, purify the mRNA by phenol extraction and ethanol precipitation as described above or using a commercial RNA purification column.Lithium chloride selectively precipitates large RNA such as mRNA, while small RNA such as tRNA1. Add 1 volume of 5 M LiCl solution to the sample and mix well.2. Incubate on ice or at -20 °C for 30 minutes.3. Pellet the RNA in a microcentrifuge for 30 minutes at full speed at 4 °C.4. Carefully remove and discard the supernatant Which contains the tRNA, other small RNAs andnucleotides. Do not disturb the RNA pellet which contains the mRNA.5. Wash the RNA pellet with 70% ethanol to remove residual salt.6. Resuspend the RNA pellet in RNase-free Water or TE buffer.7. (Optional) Analyse the effectiveness of the Terminator reaction by denaturing agarose gelelectrophoresis or using an Agilent 2100 Bioanalyzer. When using either method, it is important to run an untreated RNA sample (~250 ng of total RNA) alongside the treated sample. Theabsence of 18S and 28S rRNA in the post-treatment sample indicates a successful reaction.7. Further supportIf you require any further support, please do not hesitate to contact our Technical Support Team:************************.All trademarks and registered trademarks mentioned herein are the property of their respective owners. All other trademarks and registered trademarks are the property of LGC and its subsidiaries. Specifications, terms and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording or any retrieval system, without the written permission of the copyright holder. © LGC Limited, 2023. All rights reserved. GEN/894/EK/0223@LGCBiosearch。
BCX51 52 53 PNP中间功率导电器SOT89数据手册说明书
Features• BV CEO > -45V, -60V & -80V• I C = -1A Continuous Collector Current • I CM = -2A Peak Pulse Current• Low Saturation Voltage V CE(sat) <************• Gain Groups 10 and 16• Complementary NPN Types: BCX54, 55, and 56• Totally Lead-Free & Fully RoHS Compliant (Notes 1 & 2) • Halogen- and Antimony-Free. "Green" Device (Note 3)•For automotive applications requiring specific change control (i.e. parts qualified to AEC-Q100/101/200, PPAPcapable, and manufactured in IATF 16949 certified facilities),please contact us or your local Diodes representative.https:///quality/product-definitions/Mechanical Data• Case: SOT89• Case Material: Molded Plastic, “Green” Molding Compound; UL Flammability Rating 94V-0• Moisture Sensitivity: Level 1 per J-STD-020•Terminals: Matte Tin Finish Leads; Solderable per MIL-STD-202 Method 208•Weight: 0.052 grams (Approximate)Applications • Medium Power Switching or Amplification Applications • AF Driver and Output StagesOrdering Information (Note 4)Product Compliance Marking Reel Size (inches)Tape Width (mm)Quantity per ReelBCX51TA Standard AA 7 12 1,000 BCX51-13R Standard AA 13 12 4,000 BCX5110TA Standard AC 7 12 1,000 BCX5116TA Standard AD 7 12 1,000 BCX5116TC Standard AD 13 12 4,000 BCX52TA Standard AE 7 12 1,000 BCX5210TA Standard AG 7 12 1,000 BCX5216TA Standard AM 7 12 1,000 BCX53TA Standard AH 7 12 1,000 BCX5310TA Standard AK 7 12 1,000 BCX5316TA Standard AL 7 12 1,000 BCX5316TC Standard AL 13 12 4,000 BCX5316-13R Standard AL 13 12 4,000 BCX5110TC Standard AC 13 12 4,000 BCX51TC Standard AA 13 12 4,000 BCX5210TC Standard AG 13 12 4,000 BCX5216TC Standard AM 13 12 4,000 BCX52TC Standard AE 13 12 4,000 BCX5310TC Standard AK 13 12 4,000 BCX53TCStandardAH13124,000Notes: 1. No purposely added lead. Fully EU Directive 2002/95/EC (RoHS), 2011/65/EU (RoHS 2) & 2015/863/EU (RoHS 3) compliant.2. See https:///quality/lead-free/ for more information about Diodes Incorporated’s definitions of Halogen- and Antimony-free, "Green" and Lead-free.3. Halogen- and Antimony-free "Green” products are defined as those which contain <900ppm bromine, <900ppm chlorine (<1500ppm total Br + Cl) and <1000ppm antimony compounds.4. For packaging details, go to our website at https:///design/support/packaging/diodes-packaging/.Top View Device SymbolTop View Pin-Out SOT89E C BMarking InformationAbsolute Maximum Ratings (@ T A = +25°C, unless otherwise specified.)CharacteristicSymbol BCX51 BCX52 BCX53 Unit Collector-Base Voltage V CBO -45 -60 -100 V Collector-Emitter Voltage V CEO -45-60 -80V Emitter-Base Voltage V EBO -5 V Continuous Collector CurrentI C -1 A Peak Pulse Collector Current (Single pulse) I CM -2 Continuous Base CurrentI B -100 mAPeak Pulse Base Current (Single pulse) I BM-200Thermal Characteristics (@ T A = +25°C, unless otherwise specified.)CharacteristicSymbol Value Unit Power Dissipation(Note 5) P D1 W(Note 6) 1.5 (Note 7) 2.0 Thermal Resistance, Junction to Ambient Air (Note 5) R θJA 125 °C/W (Note 6) 83 (Note 7)60 Thermal Resistance, Junction to Lead (Note 8) R θJL 13 °C/W Thermal Resistance, Junction to Case (Note 9)R θJC 27 °C/W Operating and Storage Temperature Range T J, T STG-55 to +150°CESD Ratings (Note 10)CharacteristicSymbol Value Unit JEDEC ClassElectrostatic Discharge - Human Body Model ESD HBM 4,000 V 3A Electrostatic Discharge - Machine ModelESD MM400VCNotes: 5. For a device mounted with the exposed collector pad on 15mm x 15mm 1oz copper that is on a single-sided 1.6mm FR4 PCB; device is measured under still air conditions whilst operating in a steady-state.6. Same as Note 5, except the device is mounted on 25mm x 25mm 1oz copper.7. Same as Note 5, except the device is mounted on 50mm x 50mm 1oz copper.8. Thermal resistance from junction to solder-point (on the exposed collector pad).9. Thermal resistance from junction to the top of the case.10. Refer to JEDEC specification JESD22-A114 and JESD22-A115.xx = Product Type Marking Code, as follows:BCX51 = AA BCX52 = AEBCX53 = AH BCX5110 = AC BCX5210 = AG BCX5310 = AK BCX5116 = AD BCX5216 = AMBCX5316 = ALThermal Characteristics and Derating Information2550751001251500.00.20.40.60.81.0Derating CurveTemperature (°C) M a x P o w e r D i s s i p a t i o n (W )Transient Therm al Im pedanceT h e r m a l R e s i s t a n c e (°C /W )Pulse Width (s)Pulse Power DissipationPulse Width (s)M a x P o w e r D i s s i p a t i o n (W )Copper Area (sqmm)M a x i m u m P o w e r (W )Copper Area (sqmm)T h e r m a l R e s i s t a n c e (°C /W )Note:11. Measured under pulsed conditions. Pulse width ≤ 300µs. Duty cycle ≤ 2%.Typical Electrical Characteristics (@ T A = +25°C, unless otherwise specified.)-I , COLLECTOR CURRENT (A)C h ,D C C U R RE N T G A I NF E Fig. 2 Typical DC Current Gain vs. Collector CurrentDC Current Gain vs. Collector Current -V , COLLECTOR-EMITTER VOLTAGE (V)CE I , C O L L E C T O R C U R R E N T (A )CFig. 1 Typical Collector Current vs. Collector-Emitter VoltageCollector Current vs. Collector-Emitter Voltage -h FE V I CI C V V CETypical Electrical Characteristics (continued.)0.20.40.60.81.0-V , B A S E -E M I T T E R T U R N -O N V O L T A G E (V )B E (O N)-I , COLLECTOR CURRENT (A)C -V , C O L L E C T O R -E M I T T E R S A T U R A T I O N V O L T A G E (V )C E (S A T )Fig. 4 Typical Collector-Emitter Saturation Voltagevs. Collector Current 0.20.40.60.81.01.2-V , B A S E -E M I T T E R S A T U R A T I O N V O L T A G E (V B E (S AT )-I , COLLECTOR CURRENT (mA)C f , G A I N -B A ND W I D T H P R O D U C T (M H z )T Fig. 6 Typical Gain-Bandwidth Product vs. Collector Current V , REVERSE VOLTAGE (V)R C A P A C I T A N C E (p F )Fig. 7 Typical Capacitance Characteristics -V B E (s a t ), B A S E -E M I T T E R S A T U R A T I O N V O L T A G E )-V B E (o n ), B A S E -E M I T T E R T U R N -O N V O L T A G E (V )-V C E (s a t ) , C O L L E C T O R -E M I T T E RC v V RVCE(sat) V I Cf T V I CPackage Outline DimensionsPlease see /package-outlines.html for the latest version.SOT89SOT89Dim Min Max TypA 1.40 1.60 1.50B 0.50 0.62 0.56B1 0.42 0.540.48c 0.35 0.43 0.38D 4.40 4.60 4.50D1 1.62 1.83 1.733D2 1.61 1.81 1.71E 2.40 2.60 2.50E2 2.05 2.35 2.20e - - 1.50H 3.95 4.25 4.10H1 2.63 2.93 2.78L 0.90 1.20 1.05L1 0.327 0.527 0.427z 0.20 0.40 0.30All Dimensions in mmSuggested Pad LayoutPlease see /package-outlines.html for the latest version.SOT89Dimensions Value(in mm)C 1.500G 0.244X 0.580X1 0.760X2 1.933Y 1.730Y1 3.030Y2 1.500Y3 0.770Y4 4.530TOP VIEW。
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10. 请联系瑞萨电子销售处细节,以环境问题,如环境 每个瑞萨电子产品兼容性.请使用瑞萨电子产品符合所有适用 调控受控物质列入或使用,包括但不限于欧盟RoHS法规 指示.瑞萨电子承担对于因您不遵守适用法律法规而导致损害或损失不承担任何责任.
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风冷模块机组使用说明书
风冷模块机组功能说明书1.0概述DFSS-5MK控制器适用于水源冷（热）水机组，可以控制单台或6压缩机，控制器由室外主板和室内线控器组成，并有风盘联动接口。
2.0主要技术参数2.1使用条件运行电压： AC220V±10％；运行环境温度： -20～+55℃；储存温度： -35～+85℃；湿度要求： 0～95％RH2.2温度控制精度： 1℃2.3控制器符合□ GB4706．1-1988《家用和类似用途电器的安全第一部分：通用要求》□ GB4706．32-1996《家用和类似用途电器的安全热泵﹑空调器和除湿机的特殊要求》□GB18430．1-2001《蒸汽压缩机循环冷水（热泵）机组工商业用和类似用途的冷水（热泵）机组》□GB18430．2-2001《蒸汽压缩机循环冷水（热泵）机组户用和类似用途的冷水（热泵）机组》□抗干扰度符合GB4343．2-1999□印刷电路板符合GB4588．1和GB4588．2的规定3.0控制器功能制冷运行制热运行可显示回水温度及设置温度，具有查询功能掉电自动记忆各种参数压缩机均衡运行及分时启动三相缺相，逆相保护具有完善的保护功能及显示具有风盘联动接口选用摩托罗拉高性能芯片,抗干扰性能达到最好具有定时开关机功能4.0面板操作室内线控器面板如图一4.1.开关机按“运转/停止”键，机组开机，指示灯亮；再按“运转/停止”键，机组关闭，指示灯灭。
开机，关机均存储数据。
4.2.模式转换按“模式”键，选择所需的模式,“制冷”“制热”模式“制冷”模式显示雪花符号“制热”模式显示太阳符号(默认在关机状态下才可转换模式)4.3.定时开关机设置〖b7〗设置为0时是组合定时（设置请参阅下面设置章节）开机状态下，按“定时”键，定时关机；关机状态下，按“定时”键，定时开机；按“定时”键后，小时时间闪显；按“时间▽△”键，调整小时定时时间再按“定时”键后，分钟时间闪显；按“时间▽△”键，调整分钟定时时间再按“定时”键，定时设定完成再按“定时”键，则取消定时设置〖b7〗设置为1时是循环定时按“定时”键后，小时时间闪显，开始设定定时开时间；按“时间▽△”键，调整小时定时开时间再按“定时”键后，分钟时间闪显；按“时间▽△”键，调整分钟定时开时间再按“定时”键，小时时间闪显，定时开时间设定完毕，开始设定定时关时间；按“时间▽△”键，调整小时定时关时间再按“定时”键后，分钟时间闪显；按“时间▽△”键，调整分钟定时关时间按“定时”键，定时关时间设定完成4.4.时钟设定按住“定时”键5秒键后，小时时间闪显，进入时钟设定状态；按“时间▽△”键，调整小时时钟再按“定时”键后，分钟时间闪显；按“时间▽△”键，调整分钟时钟再按“定时”键，时钟设定完成4.5.查询循环定时（〖b7〗设置为1）时，按“查询”键可显示实时时间。
烙克赛克产品索引(中文版)
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CY8CMBR3XXX_CapSense Design Guide(Chinese)
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CY8CMBR3xxx CapSense 设计指南
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简介 ................................................................................................................................................................................. 6 1.1 1.2 1.3 1.4 1.5 1.6 摘要 ....................................................................................................................................................................... 6 简介 ....................................................................................................................................................................... 6 CY8CMBR3xxx 系列特性概述 ............................................................................................................................... 7 CY8CMBR3xxx 系列的特性比较 ............................................................................................................................ 9 CY8CMBR3xxx CapSense 的系统概述 ............................................................................................................... 10 CapSense 设计流程............................................................................................................................................. 11
Sartorius 萨托利斯 Sartocheck 5 Plus 滤器完整性测试仪 产品手册说明书
Product InformationThe Sartocheck® 5 Plus represents the ideal intersection point of today’s most relevant industry requirements for filter integrity testing within demanding GMP environments. A combination of a unique approach to Quality Risk Management (QRM) as well as optimal data integrity, intuitive usability, and minimized risk factors for Health, Safety, and Environment (HSE) set a new standard for filter integrity test devices.Sartocheck® 5 Plus Filter TesterKeeps Your Risk Factors Under Complete ControlNew Software Release Q1 2023 - Version 2.2.1Data Integrity-Custom Linux-based OS with SSB custom architecture-Audit trail with time zone-synchronized (NTP) events-Write-protected and constantly monitored root file system-Encrypted double data backup | redundant data storage-4 eyes principle | electronic signatures-Comprehensive and flexible role management-Locking out user after X number of unsuccessfullogin attempts-Serial number of the device in every audit trail entry-Easy to read audit trail on the screen-Harmonized time representations-A major update of the root file system of the SC5 inthe Q2 2022 release will further strengthen the datasecurity aspects of the software-Mandatory “Why” comment when modifying programparameters (Q2 2022)-Blocking of abusive test attempts (Q2 2022)Request the Data Integrity statement for more details.CCS, HSE | OSH-Splash-proof (IP64)-Ex-proof (ATEX IECEx & FM certified)-Safe testing and re-testing of alcohol-wetted filters-Continuous and clear visualization of pressure status-Resistant to all current cleaning agents-H2O2-vapor-resistant (VHP)-PFA tubings (FDA 21 CFR 177 and USP Class VIcompliant)-Optional kit for automated cleaning of the pneumaticswith up to 0.5 M NaOH at 50 °C, available in Q3 2022(requires at least software version 2.0.0). See theC ontamination Control Strategy documentationfor additional information-Optional accessory kit for backflow protection(26787---AK---EV)Quality Risk Management-Automatic detection of incorrect test setups-Program-specific min. and max. values for volumedetermination-Program-specific min. diffusion | intrusion values-Program-specific min. flow at pressure end duringa bubble point test-Automatic detection of abnormal test conditions-Detection of abnormal pressure increase-Detection of environmental temperature outsideprerequisite conditions and temperature changes(roadmap – requires sensor)-Detection of unstable test values(roadmap – pat. pending)-Self-test at booting and before each test-Comprehensive Failure Mode Effects Analysis (FMEA),including instructions for setting program-specificQRM values to avoid false passed and false failedtest results-Calculation tool for the impact of unlikely calibrationoffsetsUsability-Intuitive iF-design-rewarded Human Machine Interface(HMI)-12.1" bright touchscreen with a ± 88° viewing angle-Large digital keypad - no need for a pen –compatible with glove use-10 system languages-LDAP: log on with network user credentials-Automatic test time for faster testing-Data transfer-Automation by OPC UA or Modbus TCP-Additional keyboards (Korean and Cyrillic)-LDAP group-based role management-Filtering of displayed audit trail events-Audit trail export in a digitally signed write-protected PDF-Remote administration via OPC UA-Memory management (21CFR Part 11)-Printing via printer server-DNS name support-Scheduled export of the audit trail in PDF format-Improved program parameters for large crossflow system(TFF) systemsSurpass the Requirements of QRMThe regulatory focus on QRM (cf. ICHQ9 and the newAnnex 1 written by EMA in cooperation with the US-FDA,WHO, and PICs) also applies to filter integrity testing,as a fundamental element of sterility assurance.The Sartocheck® 5 Plus Filter Tester uses program-specificparameters allowing the automatic identification oftesting anomalies before or during the test. This preventstime-consuming, costly variations, potential drug recalls,and 483 warning letters.Experience the Comfort of Intuitive UsabilityAn optimal user experience speeds up process workflowsdue to intuitive guidance and ease of use. The high-qualitytouchscreen of the Sartocheck® 5 Plus Filter Testerprovides a unique viewing angle, an intuitive user interface,a logical menu structure, and simple data entry options.This allows straightforward programming of tests andQRM enhancement features, as well as error-free operationin GMP production environments.Reach the Ultimate Level of Data IntegrityFilter integrity test values are part of the batch protocoland are used to justify the drug release. Long-term reliabledata is crucial to avoid quality deviations and potential 483warning letters.The integrity and security of filter integrity test data mustnot be seen only as an IT problem, but also as a potentialglobal business risk. Low standards of data integrity andsecurity may not only jeopardize the activities of the drugmanufacturing company, but more critically, endanger thehealth of patients.Discover the Simplicity of HSEIntegrity testing often involves the use of chemicals andhazardous materials, e.g., alcohol. The Sartocheck® 5 Plusis certified for use in explosion-hazardous areas (ATEX)and is compatible with all current cleaning agentsand VHP. This ensures maximum safety for operatorsand manufacturing facilities.Pneumatics Max. inlet pressure 8,000 mbar | 116 psiOverpressure protection Max. inlet pressure + 4,000 mbar Min. inlet pressure 4,000 mbar | 58 psiInternal reference volume1,023 mL conforming to Pressure Equipment Directive 2014/68/EU max. Pressure = 12 bar pressurecertificateMeasuring Accuracies Measured pressure± 0.1% full scale(± 7.2 mbar | ± 0.104 psi)Measured pressure drop0.2% of the measured value before rounding Volume determination± 4%Diffusion ± 5% or 0.05 mL/min, whichever is higher Intrusion ± 5% or 0.05 mL/min, whichever is higherstarting pressure to one pressure step above the min. bubble pointDimensions, Weight, and Noise Dimensions (W × D × H)348 × 379 × 286 mm Weight16.8 kg Weight of the packaging 2.2 kg Cargo | gross weight 20.6 kg Cargo volume 95,304 cm 3Cargo dimensions 570 × 440 × 380 mmMax. noise at 1 m during depressurization with venting tubings68 dB(A) at 6,600 mbar (95.7 psi)51 dB(A) at 3,000 mbar (47.9 psi)Manufacturing SiteDesigned, developed, and manufactured in Germany Otto-Brenner Strasse 20Goettingen, GermanyEnd-user TrainingThe Sartocheck® comes with end-user training.Technical DataTest Methods DiffusionBubble point (detection by over proportionality)Combined diffusion and bubble point Water intrusion test Pressure drop | leak testMeasuring Ranges Diffusion andintrusion test pressure 50.0 – 6,600.0 mbar | 0.725 – 95.725 psi Programmable max. diffusion flow 0.011 – 4,800.000 mL/min.Programmable max. intrusion water flow0.006 mL/min. – 60.000 mL/min.Max measurable | displayable diffusion flow24,000.00 mL/min. (5 times the max. programmable value)Max. measurable | displayable intrusion water flow 300.00 mL/min. (5 times the max.programmable value)Programmable min.bubble point250.0 – 6,550.0 mbar | 3.626 – 95.000 psiProgrammable pressure drop (not higher than the test pressure)0.5 – 6,600.0 mbar | 0.007 – 95.725psiSample net volume with volume measurement-with int. reference vessel-with ext. reference vessel 14 L 150 L Max. sample net volume for pressure drop test1,000 LPower Supply Power requirements 100 – 240 V AC at 50 | 60 Hz Max. power input 74 W Average power usage 66 W Power consumption in standby mode14.8 WA country-specific cable is delivered with each device.Internal batteryThe Sartocheck® 5 is equipped with an internal battery. This battery (CR2032) contains less than 0.3 g lithium.Materials of Construction and RoughnessAll materials used for the external surfaces and the fluid paths are animal free.External Surfaces-Ra 1.6 μm or better -Stainless steel 304L-Heat strengthened glass (see “Screen and Protective Glass”) -Plastic polymer (Edistir® polystyrene PBBE free) painted with chemical resistant Alexit finishing coat B412-Aluminum painted with chemical resistant Alexit finishing coat B412 -Rubber feet: Taber H-18 abrasion resistant (ASTM-501C)Pneumatic Fluid Path of the Sartocheck® 5 Plus-Ra 1.6 μm or better-Aluminum (inlet valve block, no potential product contact) -Stainless steel 304L (process valve block) -Stainless steel 316L (connectors)-EPDM (connector gaskets), FDA 21 CFR 177 and USP Class VI (A) -PFA tubings, FDA 21 CFR 177 and USP Class VI (A)-PTFE (valve block membrane FDA 21 CFR 177 and USP Class VI (A)Pneumatic Fluid Path of the Accessory Kit for External Venting -Ra 1.6 μm or better-Stainless steel 304L (valves)-Stainless steel 316L (connectors)-EPDM (connector gaskets) FDA 21 CFR 177 and USP Class VI (A)External Tubings (Inlet and Test Tubing)-PFA tubings, FDA 21 CFR 177 and USP Class VI (A) -Stainless steel 316L (connectors)-EPDM (connector gaskets) FDA 21 CFR 177 and USP Class VI (A) -Sintered Polyethylene (inlet filter) -Polypropylene (inlet filter housing)-Stainless steel 316L Parker nippleScreen and Protective Glass Size12.1" (Format 16:10;262.6 × 164.7 mm | 10.34 × 6.48 inch)Type TFT LED-Backlit color Resolution 1,280 × 800 pixels Luminosity400 CD/m 2Viewing angle vertical and horizontal ± 88° (total 176°)Shock resistance Thermally toughened glassDIN EN 12150-1; IEC 60068-2-75AntiglareLS Touch Gloss 85 ± 10 | 60° on front sideConnectors and PortsAll connectors on the device are specifically defined in order to avoid mix up between different connections. E.g., the test tubing can only be connected to the outlet of the device.Pneumatic Connectors Inlet tubing towards pressurized lineParker nipple (Parker reference 26SFAW13MXN)Inlet tubing towards device Staubli RBE03 female Test tubing towards sample to be testedStaubli RBE03 femalePneumatic TubingsAll pneumatic tubings have been leak-tested at the end of manufacturing.Use only original test tubings of original length with original connectors to avoid any mix-up.Communication Ports-Industrial automation for OPC UA and Modbus TCP -Ethernet RJ45 for networking and data transfer-USB (4 ports) for software upgrades, barcode reader, and USB printerOperating Conditions Environmental temperature and humidity according to IEC 61010-10 °C to 40 °C (32 – 104 °F)From 0 °C to 31 °C 80% RH From 31 °C to 40 °C linearly decreasing to 50% RHAltitude100 m below sea level to 3000 m above sea levelIngress protection rating of the device as per EN 60529 |IEC 60529IP64 under normal conditions IP4X for use in potentially explosive atmospheres Ingress protection of the Accessory Kit for External Venting as per EN 60529 |IEC 60529IP65Explosion-prone areas (device only)Zone 2, Groupe II-B (IECEx, ATEX) |Class 1 Zone 2 Group II-B (USA)Explosion-prone areas (Accessory Kit for Venting)Zone 1 Group II-B (IECEx, ATEX) |Class 1, Div. 1, Zone 1 Group II-B (USA)Connectors on the backside1 Earth5 4 × USB (e.g. printer) 2 Future environmental,6 Future extender box temperature sensor7 RJ453 External pressure sensor 8 Industrial automation4 External valves9 PowerBack cover closed1 Device cleaning 5 Ext. reference tank2 Outlet | test tubing 6 Inlet pressure, max. 8 barg,3 Sample vent 7 External valves pressure supply4 Device ventFixation of cables1234567891234567Operating System and Memory-Custom Linux Distribution made by Sartorius -Flash memory 4 GB -RAM 2 GB-Internal inaccessible SD card 8 GB-CPU MSC NanoRISC i.MX6 D 800 MHzMemory CapacityThe memory can hold approximately 21,900 test results.At a rate of 10 tests per day, 365 days per year, the memory will be full after approximately 6 years.Test Result Calculation, Evaluation, and RoundingThe test evaluation is done before the rounding, meaning that, e.g., a measured diffusion value with 16 decimals of 4.4000000000000001 mL/min. will give a failed test if the max.diffusion value is set to 4.400 mL/min. The test result rounding is done according to the tie-breaking rule called “round half to even”. This is the default rounding mode used in IEEE 754 computing functions and operators.Storage and Transportation ConditionsFrom -10 °C to +60 °C (14 – 140 °F) at 90% RH noncondensing humidity.The original cardboard box is single-use shipping only.For subsequent shipping, please use the solid transportation box 26787---ST (see accessories).Language Options -English -German -French -Spanish -Italian-Mandarin (simplified) -Portuguese (Brazilian) -Japanese -Korean-RussianCleaning and Chemical Compatibility of External Surfaces (Based on Alexit Lacquer Compatibility)Do not use any abrasive cloth.Only smooth cloths or towels are allowed.-Spor-Klenz® Ready-To-Use Cold Sterilant -3% Hydrogen Peroxide WFI Sterile Solution -Septihol® Sterile Alcohol Solution 70% IPA -Water for injection-Sodium hydroxide (NaOH) 10% -Hydrochloric acid (HCL) 20% -Sulfuric acid (H2SO4) 20% -Acetic acid 10% -Ammoniac 10%-Quaternary ammonium compounds 0.2%-Cleansinald (Quaternary ammoniums blended with alkyl amines) -Bacterianos (Glutaraldehyde 0.5 mg/g and didecyldimethyl-ammonium chloride 1.2 mg/g; pH 3 – 5, contact time > 15 min.) -Aniospray (Ethanol 226 mg/g, Chlorure de didécyldiméthyl-ammonium 0.53 mg/g, chlorhydrate de polyhexaméthylène biguanide 0.64 mg/g contact time > 15 min.) -Amphospray (Ethanol 327.4 mg/g,N-(3-aminopropyl)-Ndodé-cylpropane- 1,3-diamine 0.33 mg/g), chlorure de didécyldiméthylammonium 1.09 mg/g),chlorhydrate de polyhexaméthylène biguanide 0.96 mg/g) -Formaldehyde 37%-Sodium hypochlorite 6%-Ethanol (60%, 70%, and pure) -Acetone (pure)-Ethyl acetate (pure) -Minncare Cold Sterilant-Vaporized Hydrogen Peroxide (VHP) at 1400 ppmCleaning of Internal PneumaticsUse only the original Accessory Kit for Cleaning (available Q3 2022)Warning!Inflammable or explosion-prone liquids must not be used for internal cleaning because the Accessory Kit for Cleaning is not compliant to hazardous areas or liquids.Use the following cleaning agents:-Sodium hydroxide up to 0.5 M at 25 °C (77 °F) -Citric acid 10% at 25 °C (77°F)-Sodium hypochlorite 10% at 25 °C (77 °F)-3% Hydrogen Peroxide at 25 °C (77 °F)Sartocheck® 5 and 5 Plus Filter Tester ComparisonFeatureSartocheck® 5Sartocheck® 5 Plus QRM-related program parameters No Yes Automation (OPC UA and Modbus TCP)No Yes Data integrityIdentical Identical HSE – ATEX | IECEx | FM Identical Identical Usability Identical Identical Accuracy Identical Identical CleanabilityIdenticalIdenticalAccessory kits(External Venting Kit and Cleaning Kit)Compatible(cleaning kit available in Q3 2022)Compatible(cleaning kit available in Q3 2022)Included software upgradesSelected upgrades are included until the software release mid of 2024Yes – A ll upgrades until the software release mid of 2024Ordering InformationSartocheck® Filter TesterDescription Article No. Sartocheck® 5 Filter Tester26787---FTEquipment included in 26787---FT Sartocheck® 5 Filter TesterInlet tubing for compressed gas 2m (26787---IT) Test tubing 2 m (26787---TT---02)Test certificateCalibration certificateInstallation and operating instructionsPower cord (region-specific)Screw driver (T20 × 100) for fixation of cables Networking cable (RJ45)Printer cable (USB)Accessories and Spare PartsDescription Article No.USB printer (without paper)YDP30Archivable paper 90 m and ink ribbon69Y03285Archivable self-adhesive paper 90 m and inkribbon69Y03286Thermal paper 5 rolls of 24 m69Y03287Self-adhesive thermal paper 5 rollsof 13 m69Y03288Inlet tubing for compressed gas 2 m26787---ITTest tubing 2 m26787---TT---02Test tubing 5 m26787---TT---05Test tubing 15 m26787---TT---15Test tubing for external venting26787---TT-AKEVComplete tubing-cable wrap for AKEV 2 m26787---02-AKEVComplete tubing-cable wrap for AKEV 5 m26787---05-AKEVAccessory Kit for External Venting26787---AK---EV(max. 10 accessorykits per device due tocalibration data)Tubing for “device vent”26787---VT---DETubing for “sample vent”26787---VT---SAAccessory kit for cleaning of the pneumatics*Germany (German manual)UK, India & US | Canada (English manual)France (French manual)Italy (Italian manual)Spain & Argentina (Spanish manual)Portugal & Brazil (Portuguese manual)China (Chinese manual)Japan (Japanese manual)Korea (Korean manual)Russia (Russian manual)Switzerland, Belgium & Canada(English, German, French & Italian manuals)South Africa , Australia | New Zealand,Israel and Denmark (English manual)26787---AKDE-CL26787---AKEN-CL26787---AKFR-CL26787---AKIT-CL26787---AKES-CL26787---AKPT-CL26787---AKCN-CL26787---AKJP-CL26787---AKKR-CL26787---AKRU-CL26787---AKVA-CL26787---AKVB-CL* For more details, please refer to the Contamination Control Strategy (CCS) datasheet.Description Article No.10 L pressure vessel including safety valveand manometer, certified for EU26787---AKPV-EUAdditional waste vessel for the accessory kitfor cleaning26787---AKWV-CLBarcode Scanner (None ATEX)26787---BSExternal reference volume26787---ERAdditional tubing for the externalreference volume26787---TE—RVSolid transportation box for theSartocheck® 5 | 5 Plus26787---STMidisart® Test Manifold for parallelbubble point1Z-LB-0002Triclamp 25 mm – Staubli nipple RBE03 open7ZML--0009Triclamp 25 mm – Staubli nipple RBE03closed7ZML--0015RBE03 openServicesDescription Article No.Validation package forSartocheck® 5 | 5 Plus26787---V3---FTSartocheck® 5 | 5 Plus installation S872QINSTSartocheck® 5 | 5 Plus installation pack(incl. travel exp.)S872QINSTPValve Kit installation S873IINSTValve Kit installation pack (incl. travel exp.)S873IINSTPSartocheck® 5 | 5 Plus IQ | OQ S872QIQOQSartocheck® 5 | 5 Plus IQ | OQservice pack (incl. travel exp.)S872QIQOQPValve Kit IQ | OQ S873IIQOQValve Kit IQ | OQ service pack (incl. travel exp.)S873IIQOQPService level agreement Advanced S872QSLAAService level agreement Comprehensive S872QSLACService level agreement Essential S872QSLAE Sartocheck® Plus Filter TesterDescription Article No.Sartocheck® 5 Plus Filter Tester26787---FT---PEquipment included in 26787---FT---PSartocheck® 5 Plus Filter TesterInlet tubing for compressed gas 2 m (26787---IT)Test tubing 2 m (26787---TT---02)Test certificateCalibration certificateInstallation and operating instructionsRisk assessment for integrity testing | FMEA (PDF)Power cord (region-specific)Screw driver (T20 × 100) for fixation of cablesNetworking cable (RJ45)Printer cable (USB)GermanySartorius Stedim Biotech GmbH August-Spindler-Strasse 11 37079 GoettingenPhone +49 551 308 0USASartorius Stedim North America Inc. 565 Johnson Avenue Bohemia, NY 11716Toll-Free +1 800 368 7178F or further contacts, visitSpecifications subject to change without notice.©2023 Copyright Sartorius Stedim Biotech GmbH, August-Spindler-Strasse 11, 37079 Goettingen, Germany Publication No. SPI2020-e。
怡万之 急诊0.2
怡万之有效针对肠杆菌科细菌
（2007年 SMART数据 抗生素 对产ESBL的大肠肺克的敏感性）
100.00% 80.00% 60.00% 40.00% 20.00% 0.00%
氨卞西 林/舒巴 坦 A/S 阿米 卡星 头孢 噻肟 头孢 他啶 头孢 曲松 头孢 西丁 环丙 沙星 头孢 吡肟 厄他 培南 亚胺 培南 三唑巴 左氧氟 坦/哌拉 沙星 LVX 西林 P/T
接触鸟类
疑有吸入因素
鹦鹉热衣原体、新型隐球菌
厌氧菌
结构性肺病（支气管扩张、肺 铜绿假单细胞、洋葱伯克霍尔德菌、金黄色葡萄球菌 囊肿、弥漫性泛细支气管炎等） 近期应用抗生素 耐药肺炎链球菌、肠道革兰阴性杆菌、铜绿假单胞菌
3. 中华医学会呼吸病学分会. 中华结核和呼吸杂志. 2006. Vol.5 ,No.29: 10
①头孢曲松或头孢噻肟联合静脉注射大环内 酯类；②静脉注射呼吸喹诺酮类联合氨基糖 苷类；③静脉注射β-内酰胺类/β-内酰胺 酶抑制剂(如阿莫西林/克拉维酸、氨苄西林 /舒巴坦)联合静脉注射大环内酯类；④厄他 培南联合静脉注射大环内酯类。
指南指出： 成人CAP 致病肺炎链球菌对青霉素高水平耐药或存在耐药高危险因素时，应选择 头孢曲松、头孢噻肟、厄他培南 、呼吸喹诺酮类或万古霉素。
不正确使用或滥用抗菌药物是导致耐药的主要因素
6. Shi. China Pharmacy 2009. Vol20. No23: 1829-1831
中国肠杆菌科中的ESBLs现状
12002至2003年对中国7家医疗中心社Fra bibliotek获得性感染患者
的2099株革兰氏阴性杆菌的研究显示 3,B：
社区获得性感染病原菌产ESBLs3:
疗患者；以及长时间驻留医院（尤其是ICU滞留患者）。
sciex 5500+技术参数
Sciex 5500+是一款高性能液相色谱-质谱联用仪器，具有出色的分辨率和灵敏度，可以广泛应用于生命科学、临床诊断、环境监测等领域。
本文将对Sciex 5500+的技术参数进行详细介绍，以便读者了解这款仪器的性能特点。
一、质谱部分1. 质谱分辨率：Sciex 5500+质谱部分采用三级四极杆线性离子阱（QQQ）设计，具有高分辨率和灵敏度，在相同条件下，能够更好地分析化合物的组分和结构。
2. 质子化学电离源：采用电喷雾（ESI）源和化学电离源（APCI），能够适应不同类型的样品，满足分析的多样性要求。
3. 质谱扫描模式：支持多种扫描模式，包括全扫描（Full scan）、多反应监测（MRM）和靶向杂合谱（Scheduled MRM），灵活性强，适用于不同的应用场景。
4. 质谱检测范围：Sciex 5500+具有宽广的检测范围，能够检测到不同浓度范围内的化合物，保证分析的全面性和准确性。
二、色谱部分1. 色谱柱温控制：色谱部分具有温控功能，能够精确控制色谱柱的温度，保证分离的稳定性和重现性。
2. 流动相控制：采用高精度的流量控制系统，能够精确调节流动相的流速和比例，保证色谱分离的高效性和准确性。
3. 运行模式：支持不同的运行模式，包括梯度洗脱和等温分离，适用于复杂样品的分析。
4. 色谱柱选择：色谱部分支持不同类型的色谱柱，包括反相柱、离子交换柱和亲和柱等，能够满足不同分析要求的需要。
三、数据处理和控制系统1. 数据采集和处理软件：Sciex 5500+配备了先进的数据采集和处理软件，能够对采集到的数据进行高效和快速的处理，提取有用信息。
2. 控制系统：具备完善的自动控制系统，能够实现全自动化的样品处理和分析，提高工作效率和数据准确性。
3. 数据接口和传输：支持多种数据接口和传输方式，包括USB、LAN 和WIFI，能够方便地和外部设备进行数据传输和共享。
Sciex 5500+作为一款高性能的液相色谱-质谱联用仪器，具有出色的技术参数和性能特点，能够满足不同领域的分析需求。
罗斯蒙特3051压力变送器产品说明书
产品说明书00813-0106-4001, Rev WE2023 年 4 月Rosemount™ 3051 压力变送器通过 Rosemount 3051 压力变送器，您将更有效地控制工厂，能够在众多压力、液位和流量应用中借助我们的产品，减少产品变化和复杂性，降低总拥有成本。
您将可以访问各种信息，方便您进行诊断、校正甚至防止出现问题。
以我们无与伦比的可靠性和丰富的经验打造的 Rosemount 3051 符合行业标准，可帮助您以更高的效率和安全性标准进行工作，从而保持全球竞争力。
Rosemount 30512023 年 4 月内容建立压力测量标准 (2)Rosemount 3051C 共平面压力变送器订购信息 (6)Rosemount 3051T 直连式变送器订购信息 (18)Rosemount 3051CF 流量计选择指南 (28)Rosemount 3051L 液位变送器订购信息 (62)技术规格 (74)Rosemount 3051 产品认证 (91)尺寸图 (92)选项外， (106)建立压力测量标准经实践检验的一流性能、可靠性和安全性■超千万装机量■参考精度为量程的 0.04%■安装总性能为量程的 0.14%■稳定性可保持在 URL 的 0.1% 长达 12 年■SIL 2/3 认证（IEC 61508）Coplanar ™平台增强安装和应用灵活性■通过集成的差压流量计、差压液位解决方案和一体化阀组提高可靠性和性能。
■安装方便，所有方案都全面组合，并经过渗漏测试和标定。
■丰富的产品满足您的应用需求。
高级功能Bluetooth ® 技术■提高生产力、可靠性和人员安全性。
无需高温作业许可。
无需攀爬储罐或建筑脚手架。
■快速组态、检修和排除故障，所有设备对技术人员触手可及，速度比传统 HART ® 连接快十倍。
诊断■回路完整性诊断将连续地监测电路，检测影响通讯信号的问题，并提供腐蚀、外罩进水或电源不稳定等警报。
赛米控丹佛斯电子 SEMiX603GAR066HDs 数据表
SEMiX ®3sTrench IGBT ModulesSEMiX603GAR066HDsFeatures•Homogeneous Si•Trench = Trenchgate technology •V CE(sat) with positive temperature coefficient•UL recognised file no. E63532Typical Applications*•Matrix Converter •Resonant Inverter•Current Source InverterRemarks•Case temperature limited to T C =125°C max.•Product reliability results are valid for T j =150°C•For short circuit: Soft R Goff recommended•Take care of over-voltage caused by stray inductanceAbsolute Maximum Ratings SymbolConditions Values UnitIGBT V CES T j =25°C 600V I C T j =175°CT c =25°C 720A T c =80°C541A I Cnom 600A I CRMI CRM = 2xI Cnom 1200A V GES -20 (20)V t psc V CC =360V V GE ≤ 15V V CES ≤ 600VT j =150°C6µs T j-40...175°C Inverse diode I F T j =175°CT c =25°C 771A T c =80°C 562A I Fnom600A I FRM I FRM = 2xI Fnom1200A I FSM t p =10ms, sin 180°, T j =25°C1800A T j-40 (175)°C Freewheeling diode I F T j =175°CT c =25°C 795A T c =80°C577A I Fnom 600A I FRM I FRM = 2xI Fnom1200A I FSM t p =10ms, sin 180°, T j =25°C1800A T j -40 (175)°C Module I t(RMS)T terminal =80°C600A T stg -40...125°C V isolAC sinus 50Hz, t =1min4000VCharacteristics SymbolConditions min.typ.max.UnitIGBT V CE(sat)I C =600A V GE =15V chiplevelT j =25°C 1.45 1.85V T j =150°C 1.7 2.1V V CE0T j =25°C 0.91V T j =150°C0.850.9V r CE V GE =15VT j =25°C 0.9 1.4m ΩT j =150°C1.42.0m ΩV GE(th)V GE =V CE , I C =9.6mA 55.86.5V I CES V GE =0V V CE =600V T j =25°C 0.150.45mA T j =150°C mA C ies V CE =25V V GE =0Vf =1MHz 37.0nF C oes f =1MHz 2.31nF C res f =1MHz1.10nF Q G V GE =- 8 V...+ 15 V 4800nC R GintT j =25°C0.67Ωt d(on)VCC =300V I C=600A V GE =±15V R G on =3ΩR G off =3ΩT j =150°C 150ns t r T j =150°C 145ns E on T j =150°C 12mJ t d(off)T j =150°C 1050ns t f T j =150°C 105ns E offT j =150°C43mJR th(j-c)per IGBT0.087K/W Inverse diodeV F = V EC I F =600AV GE =0V chipT j =25°C 1.4 1.60V T j =150°C 1.41.6V V F0T j =25°C 0.91 1.1V T j =150°C 0.750.850.95V r F T j =25°C 0.50.70.8m ΩT j =150°C0.80.9 1.1m ΩI RRM I F =600A di/dt off =3800A/µs V GE =-8VV CC =300VT j =150°C 350A Q rr T j=150°C63µC E rr T j =150°C 13mJ R th(j-c)per diode0.11K/W Freewheeling diode V F = V EC I F =600AV GE =0V chipT j =25°C 1.3 1.53V T j =150°C 1.31.5V V F0T j =25°C 0.91 1.1V T j =150°C 0.750.850.95V r F T j =25°C 0.40.60.7m ΩT j =150°C0.70.80.9m ΩI RRM I F =600A di/dt off =3800A/µs V GE =-8VV CC =300VT j =150°C 350A Q rr T j=150°C63µC E rr T j =150°C 13mJ R th(j-c)per diode0.11K/W Module L CE 20nH R CC'+EE'res., terminal-chip T C =25°C 0.7m ΩT C =125°C1m ΩR th(c-s)per module 0.04K/WM s to heat sink (M5)35Nm M t to terminals (M6)2.55Nm Nm w300g Temperatur Sensor R 100T c =100°C (R 25=5 k Ω)493 ± 5%ΩB 100/125R (T)=R 100exp[B 100/125(1/T-1/T 100)]; T[K];3550 ±2%KCharacteristics SymbolConditionsmin.typ.max.UnitSEMiX ® 3sTrench IGBT ModulesSEMiX603GAR066HDsFeatures•Homogeneous Si•Trench = Trenchgate technology •V CE(sat) with positive temperature coefficient•UL recognised file no. E63532Typical Applications*•Matrix Converter •Resonant Inverter•Current Source InverterRemarks•Case temperature limited to T C =125°C max.•Product reliability results are valid for T j =150°C•For short circuit: Soft R Goff recommended•Take care of over-voltage caused by stray inductanceFig. 1: Typ. output characteristic, inclusive R CC'+ EE'Fig. 2: Rated current vs. temperature I C = f (T C )Fig. 3: Typ. turn-on /-off energy = f (I C )Fig. 4: Typ. turn-on /-off energy = f (R G )Fig. 5: Typ. transfer characteristic Fig. 6: Typ. gate charge characteristicFig. 7: Typ. switching times vs. I C Fig. 8: Typ. switching times vs. gate resistor R GFig. 9: Typ. transient thermal impedance Fig. 10: Typ. CAL diode forward charact., incl. R CC'+EE'Fig. 11: Typ. CAL diode peak reverse recovery current Fig. 12: Typ. CAL diode recovery chargeThis is an electrostatic discharge sensitive device (ESDS), international standard IEC 60747-1, Chapter IX* The specifications of our components may not be considered as an assurance of component characteristics. Components have to be tested for the respective application. Adjustments may be necessary. The use of SEMIKRON products in life support appliances and systems is subject to prior specification and written approval by SEMIKRON. We therefore strongly recommend prior consultation of our staff.。
PPCPs
PPCPs内分泌干扰物(EDC)，也称为环境激素，是指进入动物或人体内可引起内分泌系统紊乱并造成生理异常的化学物质。
大致包括以下4类：（1）工业化学品：PCBs，甲苯，二噁英，苯并芘，氯仿，烷基酚（双酚A，壬基酚等），邻苯二甲酸酯，金属类（四乙基铅）（2）农药：乙草胺，氯丹，DDT，狄氏剂，异狄氏剂，六六六，林丹（3）天然雌激素：雌二醇，雌三醇，雌激素酮（4）药物：己烯雌酚，炔雌醇，抗生素类（阿莫西林，氯霉素，氧氟沙星，罗红霉素，诺氟沙星，四环素），降血脂类（苯扎贝特，氯贝酸），消炎药类（双氯酚酸，布洛芬，酮洛芬，甲芬那酸），兴奋剂类（咖啡因），驱虫剂类（避蚊胺），抗精神病类（舒必利），降血压类（美托洛尔，普萘洛尔）个人护理品：香料，化妆品，遮光剂，染发剂，发胶，香皂，洗发水PPCPs：药物及个人护理品含量：几十到几千ng L-1来源：制药厂、医院、水产养殖等产生的废水，城市污水处理厂，污泥回用及垃圾填埋危害：生殖系统（雌激素），致畸，恶性肿瘤（PCBs），神经系统，免疫系统关键词：地表水，环境风险，再生水，优先控制污染物，EDC，PPCPs，生态毒性，有毒有机污染物国外相关机构：美国环保局EPA，日本环境省，世界自然基金会WWF分析检测方法：（1）富集方法：萃取，索氏提取，凝胶渗透色谱（GPC）（2）分析方法：GC，HPLC，LC-MS，GC-MS，HRGC （高分辨率气象色谱）期刊杂志：（1）中文：环境科学，环境科学学报，环境科学研究，生态毒理学报，环境化学，中国环境科学，环境工程，环境工程学报（2）英文：EST（3.751），Acta Oecologica（1.143），Advances in Water Resources （1.806），Archives of Toxicology （1.852），Environmental Pollution（2.002），Environmental Research（ 1.452），Environmental Toxicology and Pharmacology （1.280），Environmental Toxicology（1.271），Science of the Total Environment （1.455），Water, Air and Soil Pollution（0.883）城市污水中一些典型PPCPs的分析方法类别目标物样品类型预处理分析技术中文名称英文名称消炎止痛药抗生素血脂调节药口服避孕药显影剂麝香其他阿司匹林水杨酸醋氨酚布洛芬双氯芬酸克拉霉素磺胺甲恶唑诺氟沙星氯霉素氯贝酸苯扎贝特17α-乙炔基雌二醇睾丸激素泛影酸钠碘美普尔碘普罗胺吐纳麝香（AHTN）佳乐麝香（HHCB）麝香酮二甲苯麝香咖啡因异环磷酸铵萘心安卡马西平acetylsalicylic acid salicylic acid acetaminophen ibuprofen diclofenac clarithromycin sulfamethoxazole norfloxacin chloramphenicol clofibric acid bezafibrate17α-ethinylestradiol Mestranol DiatrizoateIomep roliop romide tonalide gallaxolide musk ketone musk xylene caffeine ifosfamide propanolol carbamazepine 污水污水污水污水污水污泥污水污泥污泥污水污水污水污水污水污水污泥污水污水污泥污水污水污水污泥污泥污泥污水污水污水污水SPE SPE SPE SPE SPE PLE SPE PLE ASE+SPE SPE SPE SPE SPE SPE SPE LSE+GPC 在线SPE SPE USE+SPE SPE SPMELLE索氏提取LSE+GPC+SPE LSE+GPC+SPE SPESPESPESPEGS/MSGS/MSGS/MSGS/MSGS/MS/MS LC/MS/MS HPLC/MS/MS LC/MS/MS LC/FLDLC/MS/MS HPLC/MS/MS GC/MSLC/MS/MS HPLC/MS/MS LC/MSGC/MSLC/DADLC/MS/MS LC/MS/MS LC/MS/MS GC/MSGC/MSGC/MSGC/MSHRGC/MSHRGC/MSGC/MSLC/MS/MSLC/MS/MSGC/MS注：LLE—液液萃取；LSE—液固萃取；SPME—固相微萃取；SPE—固相萃取；GPC—凝胶渗透色谱；USE—超声溶剂萃取；PLE—压力溶剂萃取；DAD—二极管阵列检测器；FLD—荧光检测器；HRGC—高分辨率气相色谱。
霉酚酸在肾移植患者中有限采样法监测方案的探讨
霉酚酸在肾移植患者中有限采样法监测方案的探讨*王娟1，2，王丽彬1，郭苗1**，魏继福1**1南京医科大学第一附属医院药学部，南京210029；2南京鼓楼医院药学部，南京210008；霉酚酸(mycophenolic acid ,MPA )因肾毒性低的优点,广泛应用于肾移植术后的免疫抑制治疗[1]。
其通过选择性可逆地抑制鸟嘌呤核苷酸从头合成途径的关键酶次黄苷酸脱氢酶(inosine monophos ⁃phate dehydrogenase ,IMPDH )的活性,抑制T 、B 淋巴细胞增殖,从而发挥免疫抑制作用[2]。
多项研究表明,肾移植患者按固定剂量给药时,MPA 的药代动力学和药效学具有明显的个体间和个体内差异,其受诸多因素的影响,如性别、体重、种族、白蛋白水平、肝肾功能、移植后时间、基因多态性等[3]。
据文献报道,MPA 的血浆浓度-时间曲线下面积(area un ⁃der plasma concentration-time curve ,AUC )与其临床抗排斥效果和不良反应的发生具有明显的相关性,然而谷浓度与AUC 相关性较差[4]。
本文主要确定了吗替麦考酚酯和霉酚酸钠肠溶片的AUC 血药浓度监测简化方案,为实现MPA 在肾移植患者中的个体化应用提供参考。
1对象与方法1.1研究对象临床应用的MPA 类药物主要有吗替麦考酚酯(mycophenolate mofetil ,MMF )和霉酚酸钠肠溶片(enteric-coated mycophenolate sodium ,EC-MPS )。
本研究共纳入76例成人肾移植患者,考察MPA 的药代动力学特征。
分两组:MMF 组33例(男性21例、女性12例),年龄19~57岁;EC-MPS 组43例(男性32例、女性11例),年龄24~61岁。
所有患者均在南京医科大学第一附属医院手术及术后随访,均采用MPA 、他克莫司(Tac )、激素三联免疫抑制方案治疗。