制作团队.ppt
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CD molecules & disease
Cdmolecules and disease 1.CD molecules’normal functions: 1)CD molecules related to activation of T
cell ,TCR/CD3 Complex,CD4 Coreceptor,CD8,CD2,CD58,CD28- Costimulators
3
CD molecules & disease
According to monoclonal antibody identification method,the same differentiated antigen that can be recognized by monoclonal antibody coming from different labs are called CD (cluster of differentiation)
1
CD molecules & Disease
制作团队：
资料：冯华 樊慧慧 崔晓霈 李金枝 何平 鲁建华 张泽立
整理：冯华 翻译：崔晓霈 李金枝 樊慧慧 制作：鲁建华 何平
2000级七年制一班
2
CD molecules & disease
Concept
CD molecules,which are also called leukocyte differentiation antigen,are the surface markers appear or disappear on leukocytes (also include platelet,blood vessel endothelial cell etc) during the process of differentiation and activation.
16
CD molecules & disease
5
CD molecules & disease Classifications
CD molecules are numbered according to the time of discovery.So far,they have been named from CD1 to CD166.
6
Classification
13
ห้องสมุดไป่ตู้4
15
CD molecules & disease
2).CD molecules related to inflammatory reactions. Firstly:CDb2I and CDb2E mediate neutrophiles to
roll and combine,the monoclonal Ab that untilselection can inhibit the reaction dramatically When passing through endothelium, CD4/CD18 interacts with its ligand,playing an important role.
8
CD molecules & disease
Function 1. CD molecules take part in the recognition between immune cells and Ag or other immune cells.They also participate the activation,proliferation differentiation and immune function.
cd11a,cd44,cd49~cd51,cd61,cd62,cd102~ cd104,cdw108 cdw116,cd117,cd120~cd122,cd124,cd1276~
CD molecules & disease
All of them are classified approximately into 9 groups: T cell, B cell, activating cell, myeloid cell, NK/non-lineage cell, platelet, endoepithelial cell, adhesion molecule and cytokine receptor .
9
10
CD molecules & disease
2.Regulate the differentiation and migration of hemopoietic cells.
3.Participate inflammation. 4.Cell migration.
eg.cancer matastasis
4
CD molecules & disease
Structure Most CD molecules are transmembrane protein or glycoprotein,including extramembrancous,transmembranous and intracellular areas.
T
cell
B
cell
Activated cell
Myeloid cell
NK
cell
Platelet cell Endoepithelial cell Adhesion molecule
Cytokine
CD Serial Number cd1～cd8，cd27,cd28,cd60,cd98~cdw101 cd10,cd19~cd24,cd37,cd39,cd40,cd72~cd86 cd25,cd26,cd30,cd69~cd71,cd95~cd97 cd9,cd11b~cd17,cd31~cd36,cd64~cd68,cd8 7~cd93,cd115 cd11a,cd18,cd29,cd38,cd43,cd45~cd48,cd5 2~cd59,cd94 cd41,cd42,cd63,cd107 cd105,cd106,cdw109
12
CD molecules & disease
Cdmolecules and disease 1.CD molecules’normal functions: 1)CD molecules related to activation of T
cell ,TCR/CD3 Complex,CD4 Coreceptor,CD8,CD2,CD58,CD28- Costimulators
3
CD molecules & disease
According to monoclonal antibody identification method,the same differentiated antigen that can be recognized by monoclonal antibody coming from different labs are called CD (cluster of differentiation)
1
CD molecules & Disease
制作团队：
资料：冯华 樊慧慧 崔晓霈 李金枝 何平 鲁建华 张泽立
整理：冯华 翻译：崔晓霈 李金枝 樊慧慧 制作：鲁建华 何平
2000级七年制一班
2
CD molecules & disease
Concept
CD molecules,which are also called leukocyte differentiation antigen,are the surface markers appear or disappear on leukocytes (also include platelet,blood vessel endothelial cell etc) during the process of differentiation and activation.
16
CD molecules & disease
5
CD molecules & disease Classifications
CD molecules are numbered according to the time of discovery.So far,they have been named from CD1 to CD166.
6
Classification
13
ห้องสมุดไป่ตู้4
15
CD molecules & disease
2).CD molecules related to inflammatory reactions. Firstly:CDb2I and CDb2E mediate neutrophiles to
roll and combine,the monoclonal Ab that untilselection can inhibit the reaction dramatically When passing through endothelium, CD4/CD18 interacts with its ligand,playing an important role.
8
CD molecules & disease
Function 1. CD molecules take part in the recognition between immune cells and Ag or other immune cells.They also participate the activation,proliferation differentiation and immune function.
cd11a,cd44,cd49~cd51,cd61,cd62,cd102~ cd104,cdw108 cdw116,cd117,cd120~cd122,cd124,cd1276~
CD molecules & disease
All of them are classified approximately into 9 groups: T cell, B cell, activating cell, myeloid cell, NK/non-lineage cell, platelet, endoepithelial cell, adhesion molecule and cytokine receptor .
9
10
CD molecules & disease
2.Regulate the differentiation and migration of hemopoietic cells.
3.Participate inflammation. 4.Cell migration.
eg.cancer matastasis
4
CD molecules & disease
Structure Most CD molecules are transmembrane protein or glycoprotein,including extramembrancous,transmembranous and intracellular areas.
T
cell
B
cell
Activated cell
Myeloid cell
NK
cell
Platelet cell Endoepithelial cell Adhesion molecule
Cytokine
CD Serial Number cd1～cd8，cd27,cd28,cd60,cd98~cdw101 cd10,cd19~cd24,cd37,cd39,cd40,cd72~cd86 cd25,cd26,cd30,cd69~cd71,cd95~cd97 cd9,cd11b~cd17,cd31~cd36,cd64~cd68,cd8 7~cd93,cd115 cd11a,cd18,cd29,cd38,cd43,cd45~cd48,cd5 2~cd59,cd94 cd41,cd42,cd63,cd107 cd105,cd106,cdw109