首都医科大学免疫学2017年考博真题考博试卷
2017年全国医学博士英语统一考试试题
2017年全国医学博士英语统一考试试题2017年全国医学博士英语统一考试试题Part I Listening Comprehension(30%)略Part II Vocabulary(10%)Section ADirections:In this section,all the sentences are incomplete.Four words or phrases marked A,B,C and D are given beneath each of them.You are to choose the word or phrase that best completes the sentence,then mark your answer on the ANSWER SHEET.31.Chronic high-dose intake of vitamin A has been shown to have____effects on bones.A.adverseB.prevalentC.instantD.purposeful32.Drinking more water is good for the rest of your body,helping to lubricate joints and___toxinsand impurities.A.screen outB.knock outC.flush outD.rule out33.Rheumatologist advises that those with ongoing aches and pains first seek medical helpto____the problem.A.affiliateB.alleviateC.aggravateD.accelerate34.Generally,vaccine makers_____the virus in fertilized chicken eggs in a process that can takefour to six months.A.penetrateB.designateC.generateD.exaggerate35.Danish research shows that the increase in obese people in Denmark is roughly____to theincrease of carbon dioxide in the atmosphere.A.equivalentB.temporaryC.permanentD.relevant36.Ted was felled by a massive stroke that affected his balance and left him barely able tospeak____.A.bluntlyB.intelligiblyC.reluctantlyD.ironically37.In a technology-intensive enterprise,computers____all processes of the production andmanagement.A.dominateB.overwhelmC.substituteD.imitate38.Although most dreams apparently happen____,dream activity may be provoked by externalinfluences.A.homogeneouslyB.instantaneouslyC.spontaneouslyD.simultaneously39.We are much quicker to respond,and we respond far too quickly by giving____to our anger.A.ventB.impulseC.temperD.offence40.By maintaining a strong family_____,they are also maintaining the infrastructure of society.A.biasB.honorC.estateD.bondSection BDirections:Each of the following sentences has a word or phrase underlined.There are four words or phrases beneath each sentence.Choose the word or phrase which can best keep the meaning of the original sentence if it is substituted for the underlined part.Mark your answer on the ANSWER SHEET.rm the manager if you are on medication that makes you drowsy.A.uneasyB.sleepyC.guiltyD.fiery42.Diabetes is one of the most prevalent and potentially dangerous diseases in the world.A.crucialB.virulentC.colossalD.widespread43.Likewise,soot and smoke from fire contain a multitude of carcinogens.A.a matter ofB.a body ofC.plenty ofD.sort of44.Many questions about estrogen’s effects remain to be elucidated,and investigations areseeking answers through ongoing laboratory and clinical studies.A.implicatedB.impliedC.illuminatedD.initiated45.A network chatting is a limp substitute for meeting friends over coffee.A.accomplishmentB.refreshmentplementD.replacement46.When patients spend extended periods in hospital,they tend to become overly dependent andlose interest in taking care of themselves.A.extremelyB.exclusivelyC.exactlyD.explicitly47.Attempts to restrict parking in the city centre have further aggravated the problem of trafficcongestion.A.AmelioratedB.aggregatedC.deterioratedD.duplicated48.It was reported that bacteria contaminated up to80%of domestic retail raw chicken in theUnited States.A.inflamedB.inflictedC.infectedD.infiltrated49.Researchers recently ran the numbers on gun violence in the United States and reported thatright-to-carry-gun laws do not inhibit violent crime.A.curbB.induceC.lessenD.impel50.Regardless of our uneasiness about stereotypes,numerous studies have shown clear differencebetween Chinese and western parenting.A.specificationsB.sensationsC.conventionsD.conservations PartⅢCloze(10%)Directions:In this section there is a passage with ten numbered blanks.For each blank,there are four choices marked A,B,C and D on the right side.Choose the best answer and mark the letter of your choice on the ANSWER SHEET.It was the kind of research that gave insight into how flu strains could mutate so quickly.The same branch of research concluded in2005that the1918flu started in birds before passing to humans.Parsing this animal-human51could provide clues to52the next potential super flu,whichalready has a name:H5N1,also known as avian flu or bird flu.This potential killer also has a number:59%.According to the WHO,nearly three-fifths of the people who53H5NI since2003died from the virus,which was first reported54humans in Hong Kong in1997before a more serious55occurred in Southeast Asia between2003and2004.(It has since spread to Africa and Europe.)Some researchers argue that those mortality numbers are exaggerated because WHO only56cases in which victims are sick enough to go to the hospitals for treatment.57,compare that to the worldwide mortality rate of the1918pandemic;it may have killed roughly50million people,but that was only10%of the number of people infected,according to a2006estimate.H5NI’s saving grace—and the only reason we’re not running around masked up in public right now—is that the strain doesn’t jump from birds to humans,or from humans to humans,easily. There have been just over600cases(and359deaths)since2003.But58its lethality,and the chance it could turn into something far more transmissible,one might expect H5NI research to be exploding,with labs59the virus’s molecular components to understand how it spreads between animals and60to humans,and hoping to discover a vaccine that could head off a pandemic.51.A.rejection B.interface plement D.contamination52.A.be stopped B.stopping C.being stopped D.having stopped53.A.mutated B.effected C.infected D.contracted54.A.in B.on C.with D.from55.A.trigger unch C.outbreak D.outcome56.A.counts B.amounts to C.accounts for D.accumulates57.A.Thereafter B.Thereby C.Furthermore D.Still58.A.given B.regarding C.in spite of D.speaking of59.A.parses B.parsed C.parsing D.to parse60.A.potently B.absolutely C.potentially D.importantlyPart IV Reading Comprehension(30%)Directions:In this part,there are six passages,each of which is followed by five questions.For each question,there are four possible answers marked A,B,C,and D.Choose the best answer and mark the letter of your choice on the ANSWER SHEET.Passage OneIf you are reading this article,antibiotics have probably saved your life—and not once but several times.A rotten tooth,a knee operation,a brush with pneumonia;any number of minor infections that never turned nasty.You may not remember taking the pills,so unremarkable have these one-time wonder drugs become.Modern medicine relies on antibiotics—not just to cure diseases,but to augment the success of surgery,childbirth and cancer treatments.Yet now health authorities are warning,in uncharacteristically apocalyptic terms,that the era of antibiotics is about to end.In some ways,bacteria are continually evolving to resist the drugs.But in the past we’ve always developed new ones that killed them again.Not this time.Infections that once succumbed to everyday antibiotics now require last-resort drugs with unpleasant side effects.Others have become so difficult to treat that they kill some 25,000Europeans yearly.And some bacteria now resist every known antibiotic.Regular readers will know why:New Scientist has reported warnings about this for years.We have misused antibiotics appallingly,handing them out to humans like medicinal candy and feeding them to livestock by the tonne,mostly not for health reasons but to make meat cheaper.Now antibiotic-resistant bacteria can be found all over the world—not just in medical facilities,but everywhere from muddy puddles in India to the snows of Antarctica（南极洲）.How did we reach this point without viable successors to today’s increasingly ineffectual drugs? The answer lies not in evolution but economics.Over the past20years,nearly every major pharmaceutical company has abandoned panies must make money,and there isn’t much in short-term drugs that should be used sparingly.So researchers have discovered promising candidates,but can’t reach into the deep pockets needed to develop them.This can be fixed.As we report this week,regulatory agencies,worried medical bodies and Big Pharma are finally hatching ways to remedy this market failure.Delinking profits from the volume of drug sold(by adjusting patent rights,say,or offering prizes for innovation)has worked for other drugs,and should work for antibiotics—although there may be a worryingly long wait before they reach the market.One day,though,these will all to resistance too.Ultimately,we need,evolution-proof cures for bacterial infection:treatments that stop bacteria from causing disease,but don’t otherwise inconvenience the little blighters.When resisting drugs confers no selective advantage,drugs will stop breeding resistance.Researchers have a couple of candidates for such treatment.But they fear regulators will drag their feet over such radical approaches.That,too,can be fixed.We must not neglect development of the sustainable medicine we need,the way we have neglected simple antibiotic R&D.If we do,one day another top doctor will be telling us that the drugs no longer work—and there really will be no help on the way.61.In the first paragraph,the author is tying to_____.A.warn us against the rampant abuse of antibiotics everywhereB.suggest a course of action to reduce antibiotic resistanceC.tell us a time race between humans and bacteriaD.remind us of the universal benefit of antibiotics62.The warning from health authorities implies that_____.A.the pre-antibiotic era will returnB.the antibiotic crisis is about to repeatC.the wonder drugs are a double-edged swordD.the development of new antibiotics is too slow63.The appalling misuse of antibiotics,according to the passage,_____.A.has developed resistant bacteria worldwideB.has been mainly practiced for health reasonsC.has been seldom reported as a warning in the worldD.has been particularly worsened in the developing countries64.The market failure refers to____.A.the inability to develop more powerful antibioticsB.the existing increasingly ineffectual drugs in the marketC.the poor management of the major pharmaceutical companiesD.the deprived investment in developing new classes of antibiotics65.During the presentation of the two solutions,the author carries a tone of_____.A.doubtB.urgencyC.indifferenceD.helplessness Passage TwoThis issue of Science contains announcements for more than100different Gorgon Research Conferences，on topics that range from atomic physics to developmental biology.The brainchild（某人的主意）of Neil Gordon of Johns Hopkins University,these week-long meetings are designed to promote intimate,informal discussions of frontier science.Often confined to fewer than125 attendees,they have traditionally been held in remote places with minimal distractions.Beginning in the early1960s,I attended the summer Nucleic Acids Gordon Conference in rural New Hampshire，sharing austere（简朴的）dorm facilities in a private boy’s school with randomly assigned roommates.As a beginning scientist,I found the question period after each talk especially fascinating,providing valuable insights into the personalities and ways of thinking of many senior scientists whom I had not encountered previously.Back then,there were no cellphones and no internet,and all of the speakers seemed to stay for the entire week.During the long,session-free afternoons,graduate students mingled freely with professors.Many lifelong friendships were begun, and—as Gordon intended—new scientific collaborations began.Leap forward to today,and every scientist can gain immediate access to a vast store of scientific thought and to millions of other scientists via the Internet.Why,nevertheless,do in-person scientific meetings remain so valuable for a life in science?Part of the answer is that science works best when there is a deep mutual trust and understanding between the collaborators,which is hard to develop from a distance.But most important is the critical role that face-to-face scientific meetings play in stimulating a random collision of ideas and approaches.The best science occurs when someone combines the knowledge gained by other scientists in non-obvious ways to create a new understanding of how the world works.A successful scientist needs to deeply believe,whatever the problem being tackled,that there is always a better way to approach that problem than the path currently being taken.The scientist is then constantly on the alert for new paths to take in his or her work,which is essential for makingbreakthroughs.Thus,as much as possible,scientific meetings should be designed to expose the attendees to ways of thinking and techniques that are different from the ones that they already know.66.Assembled at Gordon Research Conference are those who____.A.are physicists and biologistsB.just start doing their sciencesC.stay in the forefront of scienceD.are accomplished senior scientists67.Speaking of the summer Nucleic Acids Gordon Conference,the author thinks highly of____.A.the personalities of senior scientistsB.the question period after each talkC.the austere facilities aroundD.the week-long duration68.It can be inferred from the author that the value of the in-person scientific conference_____.A.does not change with timesB.can be explored online exclusivelyC.lies in exchanging the advances in lie scienceD.is questioned in establishing a vast store of ideas69.The author believes that the face-to-face scientific conferences can help the attendeesbetter_____.A.understand what making a breakthrough means to themB.expose themselves to novel ideas and new approachesC.foster the passion for doing scienceD.tackle the same problem in science70.What would the author most probably talk about in the following paragraphs?A.How to explore scientific collaborations.B.How to make scientific breakthroughs.C.How to design scientific meetings.D.How to think like a genius.Passage ThreeBack in1896,the Swedish scientist Svante Arrhenius realized that by burning coal we were adding carbon dioxide to the air,and that this would warm the Earth.But he mentioned the issue only in passing（顺便地），for his calculations suggested it would not become a problem for thousands of years.Others thought that the oceans would soak up any extra CO2,so there was nothing much to worry about.That this latter argument has persisted to this day in some quarters highlights our species’propensity（倾向）to underestimate the scale of our impact on the planet.Even the Earth’s vast oceans cannot suck up CO2as quickly as we can produce it,and we now know the stored CO2is acidifying the oceans,a problem in itself.Now a handful of researchers are warning that energy sources we normally think of as innocuous could affect the planet’s climate too.If we start to extract immense amounts of power from the wind,for instance,it will have an impact on how warmth and water move around the planet,and thus on temperatures and rainfall.Just to be clear,no one is suggesting we should stop building wind farms on the basis of this risk.Aside from the huge uncertainties about the climatic effects of extracting power from the wind,our present and near-term usage is far too tiny to make any difference.For the moment,any negative consequences on the climate are massively outweighed by the effects of pumping out even more CO2.That poses by far the greater environmental threat;weaning ourselves off fossil fuels should remain the priority.Even so,now it is the time to start thinking about the long-term effects of the alternative energy sources we are turning to.Those who have already started to look at these issues report weary, indifferent or even hostile reactions to their work.That’s understandable,but disappointing.These effects may be inconsequential,in which case all that will have been wasted is some research time that may well yield interesting insights anyway. Or they may turn out to be sharply negative,in which case the more notice we have,the better.It would be unfortunate to put it mildly,to spend countless trillions replacing fossil-fuel energy infrastructure（基础建设）only to discover that its successor（替代物）is also more damaging than it need be.These climatic effects may even be beneficial.The first,tentative models suggest that extracting large amounts of energy from high-altitude jet streams would cool the planet, counteracting the effects of rising greenhouse gases.It might even be possible to build an energy infrastructure that gives us a degree of control over the weather:turning off wind turbines here, capturing more of the sun’s energy there.We may also need to rethink our long-term research priorities.The sun is ultimately the only source of energy that doesn’t end up altering the planet’s energy balance.So the best bet might be invest heavily in improving solar technology and energy storage—rather than in efforts to harness, say,nuclear fusion.For the moment,all of this remains supposition（推测）.But our species has a tendency to myopia.We have nothing to lose,and everything to gain by taking the long view for a change.71.In the first two paragraphs,the author is trying to draw our attention to____.A.the escalating scale of the global warmingB.the division of scientists over the issue of global warmingC.reasons for us to worry about extra CO2for the oceansD.the human tendency to underestimate the harmful effects on the planet72.The author’s illustration of wind-power extraction reflects____.A.the priority of protecting the environmentB.the same human propensity as mentioned previouslyC.the best strategy of reducing the environmental threatD.the definite huge uncertainties about the climatic effects73.The author argues that it would be unfortunate to replace fossil fuels only to find out that____.A.the successors are also damagingB.the countless trillions spent are wastedC.the alternative energy sources don’t workD.the research invites indifferent or even hostile reactions74.According to the author,the best strategy is____.A.to counteract the effects of rising greenhouse gasesB.to develop a degree of control over the weatherC.to extract large amounts of energy from windD.to explore solar energy and its storage75.It can be concluded from the passage that we need to take the long view on____.A.human existence on the planetB.humanity’s energy suppliesC.our environmental threatsD.our tendency to myopiaPassage FourOptical illusions are like magic,thrilling us because of their capacity to reveal the fallibility of our senses But there’s more to them than that,according to Dr.Beau Lotto,who is wowing the scientific world with work that crosses the boundaries of art,neurology,natural history and philosophy.What they reveal,he says,is that the whole world is the creation of our brain.What we see, what we hear,feel and what we think we know is not a photographic reflection of the word,but an instantaneous unthinking calculation as to what is the most useful way of seeing the world.It’s a best guess based on the past experience of the individual,a long evolutionary past that has shaped the structure of our brains.The world is literally shaped by our pasts.Dr.Lotto,40,an American who is a reader in neuroscience at University College London,has set out to prove it in stunning visual illusions,sculptures and installations,which have been included in art-science exhibitions.He explains his complex ideas from the starting point of visual illusions,which far from revealing how fragile our senses are show how remarkably robust they are at providing a picture of the world that serves a purpose to us.For centuries,artists and scientists have noted that a grey dot looks lighter against a dark background than being against a light background.The conventional belief was that it was because of some way the brain and eye is intrinsically wired.But Dr.Lotto believes it’s a learnt response;in other words,we see the world not as it is but as it is useful to us.“Context is everything,because our brains have evolved to constantly re-define normality,”says Dr.Lotto.“What we see is defined by our own experiences of the past,but also by what the human race has experienced through its history.”This is illustrated by the fact that different cultures and communities have different viewpoints of the world,conditioned over generations.For example,Japanese people have a famous inability to distinguish between the“R”and the“L”sound.This arises because in Japanese the sounds are totally interchangeable.“Differentiating between them has never been useful,so the brain has never learnt to do it.It’s not just that Japanese people find it hard to tell the difference.They literally cannot hear the difference.”Dr.Lotto’s experiments are grounding more and more hypotheses in hard science.“Yes,mywork is idea-driven,”he says.“But lots of research,such as MRI brain scanning,is technique-driven.I don’t believe you can understand the brain by taking it out of its natural environment and looking at it in a laboratory.You have to look at what it evolved to do,and look at it in relationship to its ecology.”76.What does the word“them”in the first paragraph refer to?A.Human senses.B.The fallibility of senses.C.Revealing capacity.D.Optical illusions.77.According to the passage,what is known about Dr.Beau Lotto?A.Though he is a neuroscientist,he has shocked the scientific world with his extensiveresearch in art,neurology,natural history and philosophy.B.Dr.Lotto is a professor at University College Landon who is specialized in a number ofdisciplines such as art,neurology,natural history and philosophy.C.Dr.Lotto has been attempting to exhibit his creative productions in art-science exhibitionsin the hope of proving his idea on optical illusions.D.Dr.Lotto has set out to create visual illusions,sculptures and installations which wellcombined the knowledge of art,neurology,natural history and philosophy.78.Which of the following statements can be inferred from Dr.Lotto’s study?A.People should believe their brains rather than their eyes as the world,to a great measure,iscreated and shaped by human brain.B.People should never believe their senses for what they see,hear,feel,and the truth may becontrary to the photographic image of the world.C.People should never believe their eyes for what they see are only accidental and temporaryforms of the world,which varies in accordance with contexts.D.People should be aware that their eyes can play tricks on them as what they see is actuallycreated by their brains which are shaped by their past experiences.79.According to Dr.Lotto,what is the reason for the fact that a grey dot looks lighter against adark background than being against a light background?A.It is a fact that the dot emerged to be lighter against a dark background than being against alight one.B.Human senses are remarkably robust at providing a picture of the world that serves apurpose to us through what they have learnt from past experiences.C.It is because of some way the brain and eye is intrinsically wired.D.Because the context in which the little dot placed has changed to be lighter.80.Which of the following statements is true about the research in neuroscience?A.Investigation on the brain involves scrutinizing a network in which both environment andthe brain itself function together.B.Both idea-driven and technique-driven are popular research methods in research study inneuroscience.C.People cannot carry out research study on brain in laboratory where it is isolated fromhuman body.D.Brain can be investigated in isolation with other faculties and organs as long as the researchis carried out in proper natural context.Passage FiveThe biggest thing in operating rooms these days is a million-dollar,multi-armed robot named da Vinci,used in nearly400,000surgeries nationwide last year—triple the number just four years earlier.But now the high-tech helper is under scrutiny over reports of problems,including several deaths that may be linked with it and the high cost of using the robotic system.There also have been a few disturbing,freak incidents:a robotic hand that wouldn’t let go of tissue grasped during surgery and a robotic arm hit-ting a patient in the face as she lay on the operating table.Is it time to curb the robot enthusiasm?Some doctors say yes,concerned that the“wow”factor and heavy marketing have boosted use. They argue that there is not enough robust research showing that robotic surgery is at least as good or better than conventional surgeries.Many U.S.hospitals promote robotic surgery in patient brochures,online and even on highway billboards.Their aim is partly to attract business that helps pay for the costly robot.The da Vinci is used for operations that include removing prostates,gallbladders and wombs, repairing heart valves,shrinking stomachs and transplanting organs.Its use has increased worldwide, but the system is most popular in the United States.For surgeons,who control the robot while sitting at a computer screen rather than standing over the patient,these operations can be less tiring.Plus robot hands don’t shake.Advocates say patients sometimes have less bleeding and often are sent home sooner than with conventional laparoscopic surgeries and operations involving large incisions.But the Food and Drug Administration is looking into a spike in reported problems during robotic surgeries.Earlier this year,the FDA began a survey of surgeons using the robotic system. The agency conducts such surveys of devices routinely,but FDA spokeswoman Synim Rivers said the reason for it now“is the increase in number of reports received”about da Vinci.Reports filed since early last year include at least five deaths.Whether there truly are more problems recently is uncertain.Rivers said she couldn’t quantify the increase and that it may simply reflect more awareness among doctors and hospitals about the need to report problems.Doctors aren’t required to report such things;device makers and hospitals are.Company spokesman Geoff Curtis said Intuitive Surgical has physician-educators and other trainers who teach surgeons how to use the robot.But they don’t train them how to do specific procedures robotically,he said,and that it’s up to hospitals and surgeons to decide“if and when a surgeon is ready to perform robotic cases.”A2010New England Journal of Medicine essay by a doctor and a health policy analyst said surgeons must do at least150procedures to become adept at using the robotic system.But there is no expert consensus on how much training is needed.New Jersey banker Alexis Grattan did a lot of online research before her gallbladder was removed last month at Hackensack University Medical Center.She said the surgeon’s many years of experience with robotic operations was an important factor.She also had heard that the surgeon was among the first to do the robotic operation with just one small incision in the belly button,instead of four cuts in conventional keyhole surgery.81.Why did FDA begin to scrutinize da Vinci?A.The number used in operation has been tripled.B.It is too expensive.C.It is reported to have frequent mechanical breakdown.wsuits increase with death case reports.82.According to some doctors,which of the following is NOT the reason to curb the enthusiasmfor da Vinci?A.The high cost causes unreasonable marketing.B.It is not as good as traditional surgeries.C.It needs more statistics to prove its value.D.It is necessary for doctors to consider some problems.83.What does FDA spokeswoman Synim Rivers mean?A.Doctors and hospitals should be responsible for those problems.B.It is doctors that think da Vinci robots are problematic.C.There are so many problems reports that FDA has to do an enquiry.D.FDA hasn’t finished the previous enquiry about the surgeons who used robots.84.What is correct about training according to the Geoff Curtis?A.A lack of sufficient training on the part of surgeons.B.A lack of sufficient training an the part of company.C.Doctors and hospitals are not sufficiently trained on specific procedures.D.Doctors and hospitals are not sufficiently trained on how to use robots.85.What is the best title for this passage?A.Four Hands Better than Two?B.Too Good to Be TrueC.Smart RobotsD.Who Is the Killer?Passage SixIn a poor,inland,gang-infested part of Los Angeles,there is a clinic for people with type1 diabetes.As part of the country health care system,it serves persons who have fallen through all other safety-net options,the poorest of the poor.Although type2diabetes is rampant in this part of。
首都医科大学病理学2000年考博真题试卷
A、抗感染及保护创面B、修复表皮
C、机化血凝块，坏死组织D、机化异物
E、填补伤口及其它组织缺损
2、风湿病的早期病变在镜下见到的是：
A、结缔组织基质蛋白多糖增多B、胶原纤维肿胀、断裂
C、浆液渗出及少量炎细胞浸润
D、阿少夫结节形成E、纤维母细胞增生
3、矽肺这种职业病对人的危害在于：
C、炎症对机体有利，又有潜在危害性
D、凡是炎症都运用抗菌素抗炎
E、炎症即有局部反应，又可有全身反应
18、下列哪一项对遗传病的特点描述最准确？
A、先天性B、遗传物质的改变C、终生性
D、家族性E、垂直传递性
19、一青年农妇数年劳动后心悸气促日益加重，近年来丧失劳动力，但日常生活尚能自理，傍晚与家人谈话突然晕倒不省人事，右上、下肢不能活动，血压正常，有可能的诊断是：
C倾向于淋巴道转移D切除后易复发E切除后不复发
1鼻咽鳞状细胞癌2喉鳞状细胞癌
2、（2.5分）A细静脉内皮细胞收缩
B仅毛细血管内皮细胞损伤
C毛细血管和小静脉内皮细胞损伤
D仅细静脉内皮细胞损伤
E细动脉，毛细血管和细静脉内皮细胞均损伤
1速发短暂反应时有2速发持续反应时有3迟发持续反应时有
三、C型题：在以下每道试题中，为每个题干选出1个正确答案。如果题干中的问题只与备选答案A有关，则选A；只与B有关，则选B；与A和B均有关，则选C；与A和B均无关，则选D。并在相应的题号后写出答案的字母。（共2小题，总计5.5分）
16、炎症反应的防御作用，应除外下列哪项？
A、炎性渗出有利于清除、消灭致病因子
B、液体的渗出可稀释毒素
C、吞噬搬运坏死组织，有利于再生和修复
D、吞噬细胞溶酶体成分外溢有利于炎症介质的形成
首都医科大学肿瘤学2017年考博真题试卷
首都医科大学医学考博真题试卷源自攻读博士学位研究生入学考试试卷
首都医科大学
2017年攻读博士学位研究生入学考试试题
考试科目：肿瘤学 注意：所有答案一律写在答题纸上，写在试题纸上或其他地方一律不给分。 一、名词解释（4 *5分=20分） 1、肿瘤微环境
第1页 共1页
2、car-t 3、自噬 4、CTV 二、简单题（4*10分=40分） 1、简述肿瘤综合治疗的原则？ 2、结直肠癌的发生的高危因素？ 3、哪些病毒感染与哪些肿瘤相关？ 4、简述肿瘤化疗的原则？ 三、论述题（2*20分=40分） 1、靶向药物的定义、作用机制、谈谈你对靶向药物的认识？ 2、一个很长的病例分析，右下腹占位，ca199及cea增高。诊断：结肠癌 问题： （1）该病的诊断？诊断依据？治疗方法？ （2）还需完善哪些检查？各自特点？ （3）谈谈你对该病的认识？
解放军医学院(301医院)病理学2017年考博真题试卷
医学考博真题试卷
攻读博士学位研究生入学考试试卷
解放军医学院（301医院）
2017年攻读博士学位研究生入学考试试题
考试科目：病理学
注意：所有答案一律写在答题纸上，写在试题纸上或其他地方一律不给分。
一、单选题（10个）
1.肝细胞癌最常见的转移部位。A肝，B肺，C骨，D肝门淋巴结。
2.早期胃癌。
6.Barrett食管
7.肝豆状核变性
8.GIST
9.Crohn病
10.Budd-Chiria综合征
三、简答题（6个）
1.慢性胃炎病因。
2.消化性溃疡并发症。
3.溃疡性结肠炎并发症。
4.病毒性肝炎肝细胞坏死的基本病理类型。
5.急性出血性坏死性肠炎（AHE）。
6.肝硬化病因。
四、论述题（2*15分）
1.慢性萎缩性胃炎病因，镜下病理表现。
2.门脉高压形成机制及主要临床表现。
3.早期大肠癌。
4.恶性溃疡。
5.与结肠癌不密切的疾病。
6.与肝细胞癌无关的是，A AFP，B碱性磷酸酶，C CEA，D谷丙转氨酶。
7.与恶性贫血有关的胃炎。
8.我国肝硬化主要病因。（好像是肝硬化）
9.
10.
二、名词解释（10个）
1.胃粘膜肠上皮化生
2.早期胃癌。
3.急性出血
2006-2015年首都医科大学考博生理原题及答案(自整理)
2006-2015年首都医科大学考博生理原题及答案(自整理)名词解释：1、all-or-none (2012)细胞产生动作电位的特点是，当刺激强度小于阈刺激时，细胞不产生动作电位，当刺激强度等于或大于阈强度时，细胞即产生动作电位，且幅度不再加大，此种现象称为“全或无”。
即动作电位的大小不随刺激强度的改变而改变。
2、recurrent inhibition (2012)是指某一中枢的神经元兴奋时，其传出冲动沿轴突外传，同时又经轴突侧支去兴奋另一抑制性中间神经元，该抑制性神经元兴奋后，其活动经轴突反过来作用于同一中枢的神经元，抑制原先发动兴奋的神经元及同一中枢的其他神经元。
3、overdrive suppression (2012)当自律细胞在受到高于其固有频率的刺激时，就按外加刺激的频率发生兴奋，称为超速驱动。
在外来的超速驱动停止后，自律细胞不能呈现其固有的自律性活动，需经一段静止期后才逐渐恢复其自律性，这种现象称为超速驱动压抑。
4、renal threshold for glucose (2012)尿中不出现葡萄糖的最高血糖浓度。
OR：近端小管对葡萄糖的吸收有一定限度。
当血糖浓度达180mg/100ml 时，有一部分肾小管对葡萄糖的吸收已达极限，尿中开始出现葡萄糖，此时的血浆葡萄糖浓度称为肾糖阈。
5、transducer function of receptor (2012)各种感受器在功能上的一个共同特点，是能把作用于它们的各种形式的刺激能量转换为传入神经的动作电位，这种能量转换称为感受器的换能作用。
6、basic electrical rhythm (2011，2010，2006)指胃肠平滑肌细胞在静息电位基础上产生缓慢的节律性的自动去极化波，又称慢波。
7、local potential (2011，2009，2007，2006)阈下刺激作用于细胞，引起膜原有的得到电位发生轻微的改变，称为局部电位。
首都医科大学病理学2015年考博真题考博试卷
医学考博真题试卷
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首都医科大学
2015 年攻读博士学位一律写在答题纸上，写在试题纸上或其他地方一律不给分。 一、名词解释 1、borderline tumor 2、primary complexion 3、lewy body 4、蜂窝织炎 5、心室壁瘤 二、选择题 1 到 9 是单选，10 到 12 是多选 三、多选题 哪些疾病可以表现出大叶性肺炎，选项有支肺、军团肺、肺鳞癌等 哪些疾病是由两种以上细胞组成，选项有畸胎瘤、精原细胞瘤、绒癌、乳腺纤 维腺瘤等 哪些疾病是感染性肉芽肿，选项有矽肺、瘤型麻风、类风湿结节等 四、简答题 1、三种导致右心肥大的疾病。 2、肿瘤的转移途径。 3、三种肝细胞病理改变。 4、什么是纤维素性炎并举例说明其病理变化。 5、六种癌前病变及导致的肿瘤。 五、论述题 1、三种人类生发系突变所致的疾病及突变的基因。 2、动脉粥样硬化的表现。 3、慢性宫颈炎伴宫颈糜烂发展为宫颈癌的过程。 4、病理学主要研究方法及研究进展，临床应用。
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2017年医学博士外语真题试卷一(精选).doc
2017年医学博士外语真题试卷一（精选）(总分：126.00，做题时间：90分钟)1.Section A（分数：2.00）__________________________________________________________________________________________ 2.Rheumatologist advises that those with ongoing aches and pains first seek medical help to______ the problem.（分数：2.00）A.affiliateB.alleviateC.aggravateD.accelerate3.An allergy results when the body have a(n)______reaction to certain substances introduced to it.（分数：2.00）A.spontaneousB.negativeC.adverseD.prompt4.Diabetes is one of the most______and potentially dangerous diseases in the world.（分数：2.00）A.crucialB.virulentC.colossalD.prevalent5.Generally, vaccine makers______the virus in fertilized chicken eggs in a process that can take four to six months.（分数：2.00）A.penetrateB.designateC.generateD.exaggerate6.Drinking more water is good for the rest of your body, helping to lubricate jointsand______toxins and impurities.（分数：2.00）A.screen outB.knock outC.flush outD.rule out7.Despite their good service provided, most inns are less expensive than hotels of______standards.（分数：2.00）A.equivalentB.likelyC.alikeD.uniform8.Chronic high-dose intake of vitamin A has been shown to have______effects on bones.（分数：2.00）A.adverseB.prevalentC.instantD.purposeful9.According to the Geneva______no prisoners of war shall be subject to abuse.（分数：2.00）A.CustomsB.CongressesC.ConventionsD.Routines10.Environmental officials insist that something be done to______acid rain.（分数：2.00）A.curbB.sueC.detoxifyD.condemn11.It is impossible to say how it will take place, because it will happen______, and it will not be a long process.（分数：2.00）A.spontaneouslyB.simultaneouslyC.principallyD.approximately12.Section B（分数：2.00）__________________________________________________________________________________________13.The patient's condition has worsened since last night.（分数：2.00）A.improvedB.returnedC.deterioratedD.changed14.Beijing Television-Station Transmitting Tower really looks magnificent at night when it's lit up .（分数：2.00）A.decoratedB.illustratedC.illuminatedD.entertained15.Because of adverse weather conditions, the travelers stopped to camp.（分数：2.00）A.localB.unfamiliarC.goodD.unfavorablerm the manager if you are on medication that makes you drowsy .（分数：2.00）A.uneasyB.sleepyC.guiltyD.fiery17.The period from 3, 000 to 1, 000 B. C. E. , when the use of bronze became common , is normally referred to as the Bronze Age.（分数：2.00）A.obviousB.significantC.necessaryD.widespread18.Diabetes is one of the most prevalent and potentially dangerous diseases in the world.（分数：2.00）A.crucialB.virulentC.colossalD.widespread19.Likewise , soot and smoke from fire contain a multitude of carcinogens.（分数：2.00）A.a matter ofB.a body ofC.plenty ofD.sort of20.Many questions about estrogen's effects remain to be elucidated , and investigations are seeking answers through ongoing laboratory and clinical studies.（分数：2.00）A.implicatedB.impliedC.illuminatedD.initiated21.The defect occurs in the first eight weeks of pregnancy, though no one understands why.（分数：2.00）A.faultB.deviationC.discretionD.discrepancy22.The applications of genetic engineering are abundant and choosing one appropriate for this case can be rather difficult.（分数：2.00）A.sufficientB.plentifulC.adequateD.countable三、PartⅢ Cloze(总题数：1，分数：20.00)It was the kind of research that gave insight into how flu strains could mutate so quickly. (One theory behind the 1918 version's sudden demise after wreaking so much devastation was that it mutated to a nonlethal form. ) The same branch of research concluded in 2005 that the 1918 flu started in birds before passing to humans. Parsing this animal-human【C1】______could provide clues to【C2】______the next potential superflu, which already has a name: H5N1, also known as avian flu or bird flu. This potential killer also has a number: 59 percent. According to the World Health Organization, nearly three-fifths of the people who【C3】______H5N1 since 2003 died from the virus, which was first reported【C4】______humans in Hong Kong in 1997 before a more serious 【C5】______occurred in Southeast Asia between 2003 and 2004. (It has since spread to Africa and Europe. ) Some researchers argue that those mortality numbers are exaggerated because WHO only 【C6】______cases in which victims are sick enough to go to the hospital for treatment【C7】______compare that to the worldwide mortality rate of the 1918 pandemic; it may have killed roughly50 million people, but that was only 10 percent of the number of people infected, according toa 2006 estimate. H5N1's saving grace — and the only reason we're not running around masked up in public right now — is that the strain doesn't jump from birds to humans, or from humans to humans, easily. There have been just over 600 cases (and 359 deaths) since 2003. But【C8】______its lethality, and the chance it could turn into something far more transmissible, one might expect H5N1 research to be exploding, with labs【C9】______the virus's molecular components to understand how it spreads between animals and【C10】______to humans, and hoping to discover a vaccine that could head off a pandemic.（分数：20.00）(1).【C1】（分数：2.00）A.interactB.interfaceC.connectionD.contamination(2).【C2】（分数：2.00）A.stoppingB.stoppedC.have stoppedD.stop(3).【C3】（分数：2.00）A.contactedB.contractedC.concentratedD.infected(4).【C4】（分数：2.00）A.onB.inC.ofD.with(5).【C5】（分数：2.00）A.breakoutB.take placeC.happenD.outbreak(6).【C6】（分数：2.00）A.accountsB.numbersC.countsD.takes(7).【C7】（分数：2.00）A.MoreoverB.StillC.FurthermoreD.Thereafter(8).【C8】（分数：2.00）A.givenB.givingC.to giveD.speaking of(9).【C9】（分数：2.00）A.parsingB.parsedC.to parseD.having parsed(10).【C10】（分数：2.00）A.presentlyB.potentiallyC.potentlyD.importantly四、PartⅣ Reading Compre(总题数：6，分数：60.00)If you are reading this article, antibiotics have probably saved your life—and not once but several times. A rotten tooth, a knee operation, a brush with pneumonia; any number of minor infections that never turned nasty. You may not remember taking the pills, so unremarkable havethese one-time wonder drugs become. Modern medicine relies on antibiotics — not just to cure diseases, but to augment the success of surgery, childbirth and cancer treatments. Yet now health authorities are warning, in uncharacteristically apocalyptic terms, that the era of antibiotics is about to end. In some ways, bacteria are continually evolving to resist the drugs. But in the past we've always developed new ones that killed them again. Not this time. Infections that once succumbed to everyday antibiotics now require last-resort drugs with unpleasant side effects. Others have become so difficult to treat that they kill some 25, 000 Europeans yearly. And some bacteria now resist every known antibiotic. Regular readers will know why: New Scientist has reported warnings about this for years. We have misused antibiotics appallingly, handing them out to humans like medicinal candy and feeding them to livestock by the tonne, mostly not for health reasons but to make meat cheaper. Now antibiotic-resistant bacteria can be found all over the world — not just in medical facilities, but everywhere from muddy puddles in India to the snows of Antarctica (南极洲) . How did we reach this point without viable successors to today's increasingly ineffectual drugs? The answer lies not in evolution but economics. Over the past 20 years, nearly every major pharmaceutical company has abandoned antibiotics. Companies must make money, and there isn't much in short-term drugs that should be used sparingly. So researchers have discovered promising candidates, but can't reach into the deep pockets needed to develop them. This can be fixed. As we report this week, regulatory agencies, worried medical bodies and Big Pharma are finally hatching ways to remedy this market failure. Delinking profits from the volume of drug sold (by adjusting patent rights, say, or offering prizes for innovation) has worked for other drugs, and should work for antibiotics — although there may be a worryingly long wait before they reach the market. One day, though, these will fall to resistance too. Ultimately, we need, evolution-proof cures for bacterial infection: treatments that stop bacteria from causing disease, but don't otherwise inconvenience the little blighters. When resisting drugs confers no selective advantage, drugs will stop breeding resistance. Researchers have a couple of candidates for such treatment. But they fear regulators will drag their feet over such radical approaches. That, too, can be fixed. We must not neglect development of the sustainable medicine we need, the way we have neglected simple antibiotic R&D. If we do, one day another top doctor will be telling us that the drugs no longer work—and there really will be no help on the way.（分数：10.00）(1).In the first paragraph, the author is trying to______.（分数：2.00）A.warn us against the rampant abuse of antibiotics everywhereB.suggest a course of action to reduce antibiotic resistanceC.tell us a time race between humans and bacteriaD.remind us of the universal benefit of antibiotics(2).The warning from health authorities implies that______.（分数：2.00）A.the pre-antibiotic era will returnB.the antibiotic crisis is about to repeatC.the wonder drugs are a double-edged swordD.the development of new antibiotics is too slow(3).The appalling misuse of antibiotics, according to the passage, ______.（分数：2.00）A.has developed resistant bacteria worldwideB.has been mainly practiced for health reasonsC.has been seldom reported as a warning in the worldD.has been particularly worsened in the developing countries(4).The market failure refers to______.（分数：2.00）A.the inability to develop more powerful antibioticsB.the existing increasingly ineffectual drugs in the marketC.the poor management of the major pharmaceutical companiesD.the deprived investment in developing new classes of antibiotics(5).During the presentation of the two solutions, the author carries a tone of______.（分数：2.00）A.doubtB.urgencyC.indifferenceD.helplessnessWhere one stage of child development has been left out, or not sufficiently experienced, the child may have to go back and capture the experience of it. A good home makes this possible, for example by providing the opportunity for the child to play with a clockwork car or toy railway train up to any age if he still needs to do so. This principle, in fact, underlies all psychological treatment of children in difficulties with their development, and is the basis of work in child clinics. The beginnings of discipline are in the nursery. Even the youngest baby is taught by gradual stages to wait for food, to sleep and wake at regular intervals and so on. If the child feels the world around him is a warm and friendly one, he slowly accepts its rhythm and accustoms himself to conforming to its demands. Learning to wait for things, particularly for food, is a very important element in upbringing, and is achieved successfully only if too great demands are not made before the child can understand them. Every parent watches eagerly the child's acquisition of each new skill—the first spoken words, the first independent steps, or the beginning of reading and writing. It is often tempting to hurry the child beyond his natural learning rate, but this can set up dangerous feeling of failure and states of anxiety in the child. This might happen at any stage. A baby might be forced to use a toilet too early, a young child might be encouraged to learn to read before he knows the meaning of the words he reads. On the other hand, though, if a child is left alone too much, or without any learning opportunities, he loses his natural zest for life and his desire to find out new things for himself. Learning together is a fruit source of relationship between children and parents. By playing together, parents learn more about their children and children learn more from their parents. Toys and games which both parents and children can share are an important means of achieving this co-operation. Building-block toys, jigsaw puzzles and crossword are good examples. Parents vary greatly in their degree of strictness or indulgence towards their children. Some may be especially strict in money matters, others are severe over times of coming home at night, punctuality for meals or personal cleanliness. In general, the controls imposed represent the needs of the parents and the values of the community as much as the child's own happiness and well-being.（分数：10.00）(1).The principle underlying all treatment of developmental difficulties in children______.（分数：2.00）A.is to send them to clinicsB.offers recapture of earlier experiencesC.is in the provision of clockwork toys and trainsD.is to capture them before they are sufficiently experienced(2).The child in the nursery______.（分数：2.00）A.quickly learns to wait for foodB.doesn't initially sleep and wake at regular intervalsC.always accepts the rhythm of the world around themD.always feels the world around him is warm and friendly(3).The encouragement of children to achieve new skills______.（分数：2.00）A.can never be taken too farB.should be left to school teachersC.will always assist their developmentD.should be balanced between two extremes(4).Jigsaw puzzles are______.（分数：2.00）A.too difficult for childrenB.a kind of building-block toyC.not very entertaining for adultsD.suitable exercises for parent-child cooperation(5).Parental controls and discipline______.（分数：2.00）A.serve a dual purposeB.should be avoided as much as possibleC.reflect the values of the communityD.are designed to promote the child's happinessFor 150 years scientists have tried to determine the solar constant, the amount of solar energy that reaches the Earth. Yet, even in the most cloud-free regions of the planet, the solar constant cannot be measured precisely. Gas molecules and dust particles in the atmosphere absorb and scatter sunlight and prevent some wavelengths of the light from ever reaching the ground. With the advent of satellites, however, scientists have finally been able to measure the Sun's output without being impeded by the Earth's atmosphere. Solar Max, a satellite from the National Aeronautics and Space Administration (NASA), has been measuring the Sun's output since February 1980. Although a malfunction in the satellite's control system limited its observation for a few years, the satellite was repaired in orbit by astronauts from the space shuffle in 1984. Max's observations indicate that the solar constant is not really constant after all. The satellite's instruments have detected frequent, small variations in the Sun's energy output, generally amounting to no more than 0. 05 percent of the Sun's mean energy output and lasting from a few days to a few weeks. Scientists believe these fluctuations coincide with the appearance and disappearance of large groups of sunspots on the Sun's disk. Sunspots are relatively dark regions on the Sun's surface that have strong magnetic fields and a temperature about 2, 000 degrees Fahrenheit cooler than the rest of the Sun's surface. Particularly large fluctuations in the solar constant have coincided with sightings of large sunspot groups. In 1980, for example, Solar Max's instruments registered a 0. 3 percent drop in the solar energy reaching the Earth. At that time a sunspot group covered about 0. 6 percent of the solar disk, an area 20 times larger than the Earth's surface. Long-term variations in the solar constant are more difficult to determine. Although Solar Max's data have indicated a slow and steady decline in the Sun's output. Some scientists have thought that the satellite's aging detectors might have become less sensitive over the years, thus falsely indicating a drop in the solar constant. This possibility was dismissed, however, by comparing solar Max's observations with data from a similar instrument operating on NASA's Nimbus 7 weather satellite since 1978.（分数：10.00）(1).According to the passage, scientists believe variations in the solar constant are related to______.（分数：2.00）A.sunspot activityB.unusual weather patternsC.increased levels of dustD.fluctuations in the Earth's temperature(2).Why is it not possible to measure the solar constant accurately without a satellite?（分数：2.00）A.The Earth is too far from the Sun.B.Some areas on Earth receive more solar energy than others.C.There is not enough sunlight during the day.D.The Earth's atmosphere interferes with the sunlight.(3).Why did scientists think that Solar Max might be giving unreliable information?（分数：2.00）A.Solar Max did not work for the first few years.B.Solar Max's instruments were getting old.C.The space shuttle could not fix Solar Max's instruments.D.Nimbus 7 interfered with Solar Max's detectors.(4).The attempt to describe the solar constant can best be described as______.（分数：2.00）A.an ongoing research effortB.a question that can never be answeredC.an issue that has been resolvedD.historically interesting, but irrelevant to contemporary concerns(5).What does this passage mainly discuss?（分数：2.00）A.The components of the Earth's atmosphere,B.The launching of a weather satellite.C.The measurement of variations in the solar constant.D.The interaction of sunlight and air pollution.Optical illusions are like magic, thrilling us because of their capacity to reveal the fallibility of our senses. But there's more to them than that, according to Dr. Beau Lotto, who is wowing the scientific world with work that crosses the boundaries of art, neurology, natural history and philosophy. What they reveal, he says, is that the whole world is the creation of our brain. What we see, what we hear, feel and what we think we know is not a photographic reflection of the world, but an instantaneous unthinking calculation as to what is the most useful way of seeing the world. It's a best guess based on the past experience of the individual, a long evolutionary past that has shaped the structure of our brains. The world is literally shaped by our pasts. Dr. Lotto, 40, an American who is a reader in neuroscience at University College London, has set out to prove it in stunning visual illusions, sculptures and installations, which have been included in art-science exhibitions. He explains his complex ideas from the starting point of visual illusions, which far from revealing how fragile our senses are show how remarkably robust they are at providing a picture of the world that serves a purpose to us. For centuries, artists and scientists have noted that a grey dot looks lighter against a dark background than being against a light background. The conventional belief was that it was because of some way the brain and eye is intrinsically wired. But Dr. Lotto believes it's a learnt response; in other words, we see the world not as it is but as it is useful to us. "Context is everything, because our brains have evolved to constantly re-define normality, " says Dr. Lotto. "What we see is defined by our own experiences of the past, but also by what the human race has experienced through its history, " This is illustrated by the fact that different cultures and communities have different viewpoints of the world, conditioned over generations. For example, Japanese people have a famous inability to distinguish between the "R" and the "L" sound. This arises because in Japanese the sounds are totally interchangeable. "Differentiating between them has never been useful, so the brain has never learnt to do it. It's not just that Japanese people find it hard to tell the difference. They literally cannot hear the difference. " Dr. Lotto's experiments are grounding more and more hypotheses in hard science. "Yes, my work is idea-driven, " he says. "But lots of research, such as MRI brain scanning, is technique-driven. I don't believe you can understand the brain by taking it out of its natural environment and looking at it in a laboratory. You have to look at what it evolved to do, and look at it in relationship to its ecology. "（分数：10.00）(1).What does the word "them" in the first paragraph refer to?（分数：2.00）A.Human senses.B.The fallibility of senses.C.Revealing capacity.D.Optical illusions.(2).According to the passage, what is known about Dr. Beau Lotto?（分数：2.00）A.Though he is a neuroscientist, he has shocked the scientific world with his extensive research in art, neurology, natural history and philosophy.B.Dr. Lotto is a professor at University College London who is specialized in a number of disciplines such as art, neurology, natural history and philosophy.C.Dr. Lotto has been attempting to exhibit his creative productions in art-science exhibitions in the hope of proving his idea on optical illusions.D.Dr. Lotto has set out to create visual illusions, sculptures and installations which well combined the knowledge of art, neurology, natural history and philosophy.(3).Which of the following statements can be inferred from Dr. Lotto's study?（分数：2.00）A.People should believe their brains rather than their eyes as the world, to a great measure, is created and shaped by human brain.B.People should never believe their senses for what they see, hear, feel, and the truth may be contrary to the photographic image of the world.C.People should never believe their eyes for what they see are only accidental and temporary forms of the world, which varies in accordance with contexts.D.People should be aware that their eyes can play tricks on them as what they see is actually created by their brains which are shaped by their past experiences.(4).According to Dr. Lotto, what is the reason for the fact that a grey dot looks lighter againsta dark background than being against a light background?（分数：2.00）A.It is a fact that the dot emerged to be lighter against a dark background than being against a light one.B.Human senses are remarkably robust at providing a picture of the world that serves a purpose to us through what they have learnt from past experiences.C.It is because of some way the brain and eye is intrinsically wired.D.Because the context in which the little dot placed has changed to be lighter.(5).Which of the following statements is true about the research in neuroscience?（分数：2.00）A.Investigation on the brain involves scrutinizing a network in which both environment and the brain itself function together.B.Both idea-driven and technique-driven are popular research methods in research study in neuroscience.C.People cannot carry out research study on brain in laboratory where it is isolated from human body.D.Brain can be investigated in isolation with other faculties and organs as long as the research is carried out in proper natural context.The biggest thing in operating rooms these days is a million-dollar, multi-armed robot named da Vinci, used in nearly 400, 000 surgeries nationwide last year—triple the number just four years earlier. But now the high-tech helper is under scrutiny over reports of problems, including several deaths that may be linked with it and the high cost of using the robotic system. There also have been a few disturbing, freak incidents: a robotic hand that wouldn't let go of tissue grasped during surgery and a robotic arm hitting a patient in the face as she lay on the operating table. Is it time to curb the robot enthusiasm? Some doctors say yes, concerned that the "wow" factor and heavy marketing have boosted use. They argue that there is not enough robust research showing that robotic surgery is at least as good or better than conventional surgeries. Many U. S. hospitals promote robotic surgery in patient brochures, online and even on highway billboards. Their aim is partly to attract business that helps pay for the costly robot. The da Vinci is used for operations that include removing prostates, gallbladders and wombs, repairing heart valves, shrinking stomachs and transplanting organs. Its use has increased worldwide, but the system is most popular in the United States. For surgeons, who control the robot while sitting at a computer screen rather than standing over the patient, these operations can be less tiring. Plus robothands don't shake. Advocates say patients sometimes have less bleeding and often are sent home sooner than with conventional laparoscopic surgeries and operations involving large incisions. But the Food and Drug Administration is looking into a spike in reported problems during robotic surgeries. Earlier this year, the FDA began a survey of surgeons using the robotic system. The agency conducts such surveys of devices routinely, but FDA spokeswoman Synim Rivers said the reason for it now "is the increase in number of reports received" about da Vinci. Reports filed since early last year include at least five deaths. Whether there truly are more problems recently is uncertain. Rivers said she couldn't quantify the increase and that it may simply reflect more awareness among doctors and hospitals about the need to report problems. Doctors aren't required to report such things; device makers and hospitals are. Company spokesman Geoff Curtis said Intuitive Surgical has physician-educators and other trainers who teach surgeons how to use the robot. But they don't train them how to do specific procedures robotically, he said, and that it's up to hospitals and surgeons to decide "if and when a surgeon is ready to perform robotic cases. " A 2010 New England Journal of Medicine essay by a doctor and a health policy analyst said surgeons must do at least 150 procedures to become adept at using the robotic system. But there is no expert consensus on how much training is needed. New Jersey banker Alexis Grattan did a lot of online research before her gallbladder was removed last month at Hackensack University Medical Center. She said the surgeon's many years of experience with robotic operations was an important factor. She also had heard that the surgeon was among the first to do the robotic operation with just one small incision in the belly button, instead of four cuts in conventional keyhole surgery.（分数：10.00）(1).Why did FDA begin to scrutinize da Vinci?（分数：2.00）A.The number used in operation has been tripled.B.It is too expensive.C.It is reported to have frequent mechanical breakdown.wsuits increase with death case reports.(2).According to some doctors, which of the following is NOT the reason to curb the enthusiasm for da Vinci?（分数：2.00）A.The high cost causes unreasonable marketing.B.It is not as good as traditional surgeries.C.It needs more statistics to prove its value.D.It is necessary for doctors to consider some problems.(3).What does FDA spokeswoman Synim Rivers mean?（分数：2.00）A.Doctors and hospitals should be responsible for those problems.B.It is doctors that think da Vinci robots are problematic.C.There are so many problems reports that FDA has to do an enquiry.D.FDA hasn't finished the previous enquiry about the surgeons who used robots.(4).What is correct about training according to the Geoff Curtis?（分数：2.00）A.A lack of sufficient training on the part of surgeons.B.A lack of sufficient training on the part of company.C.Doctors and hospitals are not sufficiently trained on specific procedures.D.Doctors and hospitals are not sufficiently trained on how to used robots.(5).What is the best title for this passage?（分数：2.00）A.Four Hands Better than Two?B.Too Good to Be TrueC.Smart RobotsD.Who Is the Killer?Despite Denmark's manifest virtues, Danes never talk about how proud they are to be Danes. This would sound weird in Danish. When Danes talk to foreigners about Denmark, they always begin by。
2017年医学博士考试《外语》真题及详解
2017年医学博士考试《外语》真题(总分100, 考试时间90分钟)Section A1. Rheumatologist advises that those with ongoing aches and pains first seek medical help to______ the problem.A affiliateB alleviateC aggravateD accelerate答案:B解析：风湿病学家建议，那些持续疼痛和痛苦的人首先应该借助医疗来缓解问题。
affiliate"接纳，为……工作"，alleviate"减少，减缓"，aggravate"增加"，accelerate"加速"。
根据题意，正确答案为B。
2. An allergy results when the body have a(n)______reaction to certain substances introduced to it.A spontaneousB negativeC adverseD prompt答案:C解析：当身体对某种外来物质产生不良反应时，就会出现过敏现象。
spontaneous"同时的"，negative"负面的"，adverse"不利的"，prompt"立刻的"。
在有关过敏的语境里，一般"不良反应"用an adverse reaction，而不用negative，正确答案为C。
3. Diabetes is one of the most______and potentially dangerous diseases in the world.A crucialB virulentC colossalD prevalent答案:D解析：糖尿病是世界上最普遍的潜在危险疾病之一。
博士免疫学-超好的试题解析
博士免疫学-超好的试题解析第四军医大学一九九二年攻读博士学位研究生入学试题学科专业：传染病学考试科目: 免疫学一. 名词解释(每题4分,共32分)1. ICAM-1 细胞间黏附分子-1 （CD54）：ICAM-1是最早发现的免疫球蛋白超家族黏附分子之一，在体内分布广泛，如淋巴结和扁桃体血管内皮细胞，胸腺树突状细胞，扁桃体和肾小球上皮细胞，白细胞，巨噬细胞和成纤维细胞等，IL-1、TNF-α、IFN和LPS可促进其表达，其配体是LFA-1（integrin）和CD43.2. interleukin 12(IL-12) 白细胞介素-12：主要由B细胞产生，是由二硫键联接的异源双体，其作用为：与IL-2协同诱导CTL的分化，促进同种异体CTL反应；刺激PHA活化CD3+T细胞增殖；与IL-2协同诱导CD56+NK细胞增殖以及LAK细胞产生，促进ADCC 作用、NKSF释放，诱导CD56、CD2、CD11a、IL-2R、TNFR、LFA-1和ICAM-1等分子的表达；促进B细胞Ig类型转换，由IgM转为IgG，抑制IL-4诱导B细胞IgE合成。
3. tumor infiltrating lymphocyte 肿瘤浸润淋巴细胞：是肿瘤间质组织中的免疫活性细胞，以T细胞为主，CD3、CD4、CD8阳性T 细胞核B细胞的计数大多与患者术后生存期的长短呈正相关，但也有一部分病例相反，可能与抗原递呈、细胞活化密切相关的共刺激因子的存在与否有关，也可能由于某些肿瘤相关抗原诱导T淋巴细胞凋亡。
目前用于肿瘤的免疫治疗。
4. TCR/CD3 complex ：TCR/CD3复合物是T细胞抗原受体与一组CD3分子以非共价键结合而形成的复合物，是T细胞识别抗原和转导信号的主要单位，TCR特异识别由MHC分子提呈的抗原肽，而CD3转导T细胞活化的第一信号。
5. hematopoietin receptor family 红细胞生成素受体家族（Ⅰ型细胞因子受体家族）：其胞膜外有两个不连续的半胱氨酸残基和WSXWS基序，包括IL-2~7、IL-9、IL-11、IL-13、IL-15、GM-CSF和G-CSF受体属于此类。
北京大学基础医学院考博免疫学专业介绍,考博真题,真题解析
考博详解与指导系所名称基础医学院招生总数49系所说明本院招生计划中70％为应届本科毕业推荐直博生，其余30％采取“申请-考核”制方式招生。
导师信息可登录本院研究生网页（）查询。
招生专业：免疫学(100102)本专业计划招生6人，其中03、04方向各2人。
研究方向指导教师考试科目备注01.分子免疫学王露02.免疫分子，免疫药物王应03.淋巴细胞发育、肿瘤免疫张毓04.固有免疫相关疾病研究游富平从以下三个方面进行评价：1、语言准确性（语法和用词的准确性、语法结构的复杂性、词汇的丰富程度、发音的准确性）2、话语的长短和连贯性（内容的连贯性、寻找合适词语而造成的停顿频率及长短、表达思想的语言长短等）3、语言的灵活性和适合性（语言表达是否灵活、自然，话语是否得体，语言能否与语境、动能和目的相适应）评价成绩为：a优秀--能用外语就指定的话题进行口头交流，基本没有困难b良好--能用外语就指定的题材进行口头交流，虽有些困难，但不影响交流c及格--能用外语就指定的话题进行简单的口头交流d不及格--不具有口头表达能力中科院招收攻读硕士学位研究生入学考试英语口试暂行办法口试内容与结构分为两部分，有两名教师参加口试工作，一名教师主持口试，随时与考生交谈并评分；另一名教师专事评分，不参与交谈。
两名口试教师所给的分数各占口试成绩的50%。
4、面试过程中不要放屁，即使放了，不要承认，让三个老师互相猜疑去。
这是以上三条中最重要的一条，做不到这一条以上三条都白搭。
第一部分：考查学生理解并回答有关日常生活、家庭、工作、学习等问题的能力（3分钟）。
第二部分：考查学生连续表达的能力。
考生从所给你的问题中选择一个话题，就此话题表达自己的看法（3分钟）。
口试用材料（部分,仅供参考）part ainterlocutor(问话者)：------good morning.my name is……,and this is my colleague…..he is just going to listening to us.are your name is…..?------first of all,we’d like to know sth.about you,so i’m going to ask some questions about yourself.(从以下各项问题中选择几个适当的问题提问考生)------hometownwhere are you from?how long have you lived there?how do you like it?why?do you live near here?where about?what do you think are the good points about living in this city?------familycould you tell us sth.about you family?what does your family usually do for the weekend?what do you think about living together with your parents?------leisuredo you have any hobbies?how did you become interested in the hobbies?------study/workwhy do you choose to study at our institute?why do you want to go to graduate school instead of finding a job?what are your favorite subjects?what kind of job did you do?have you ever worked during the vacation?why do you want to go back to study instead of going on with your work?what qualifications are needed in order to do your job well?what did you enjoy most about your campus life?------future planswhat do you expect to achieve during your study if you are enrolled into this institute?do you think english is important for your future plans?in what aspects is it important?part binterlocutor(问话者)：------now i’d like you to talk about sth.for about3minutes.here is a list of topics(将一组话题或问题递给学生)，pls read the topics and choose one from the list you like to talk about.you’ll have5minutes to prepare for your talk.(5分钟后)could you tell me what you want to talk about?all right,you’ll have3minutes to give your talk.would you begin?(the interloculor may intervene only when necessary)topics/questions(只列举了一部分话题)------give your comment on the statement that“a part-time job is an important experience that everycollege student should have.”------use specific examples to set forth your views on the saying“haste makes waste”.------describe one of your own experiences to demonstrate that“nothing ever becomes real till it is experienced”------explain your understanding of the conventional belief that“age brings wisdom”------what are the current problems of college education?how to resolve them?------some people say there is no absolute truth because“truth”is defined by people and there is no objectivity whenever people are involved.does absolute truth exist or not?why?对策1.自我介绍(self-introduce)。
免疫学考博试题（2）
免疫学考博试题（2）四军医大201 3 1. 试比较T细胞受体（TCR）、B细胞受体（BCR）和NK细胞受体（NKCR）的组成，识别配体以及信号转导的异同点。
2. 以胸腺依赖抗原刺激机体产生抗体的免疫应答为例，T细胞和B细胞是如何相互作用？有哪些粘附分子和共刺激分子参与T、B细胞的相互作用？3. 肾综合征出血热(HFRS)病毒的结构基因已经搞清楚,为了证实HFRS病毒感染机体(以Balb/C小鼠为例)可产生HFRS病毒核衣壳蛋白(NP)特异性CTL,并在免疫防护中起重要作用,请应用免疫学理论和方法,设计一系统实验,加以证实。
4. 例举二个近年来细胞和分子免疫学研究中出现的新的热点,请分别评述其研究意义、发展趋势以及应用前景华中科技大学2013年同济医学院免疫学考博真题抗原表位，肿瘤特异性抗原，adcc，细胞表面标志，细胞因子，MHC，调理作用，中枢耐受，排斥反应的T细胞直接识别，沉淀反应。
1，抗体的功能区极其特点2，天然免疫及适应性免疫的特点3，乙肝疫苗接种后，抗体产生的过程及免疫机制4，迟发型型超敏的免疫学机制2013年北京协和医学院免疫试题二、选择题三、填空题MHCII与之相连的结构（恒定连I i ）IgE恒定区有（）个结构域克隆选择学说是（）提出的，因此他获得了诺贝尔奖（）指的是单条染色体上基因的特定组合四、简答题1、半抗原与载体连接成为完全抗原，试述载体蛋白的作用2、T细胞表位与B细胞表位的区别3、双向琼脂扩散的工作原理五、论述题1、初次免疫应答与再次免疫应答的区别，举出三个并说明其原理2、举出B细胞所有的亚群，并说明其各自的特点和功能北京协和医学院2013考博免疫学真题回顾（部分）一名解:hybridoma homing receptor surogate light chain MACAntibody idotype比如补体精典与旁路途径共用的分子，BCR与TCR发育区别，HLA-DM分子参与MHC2类分子组装与转运，重症肌无力产生针对何种物质的自身抗体，BCR由细胞表面免疫球蛋白和何种物质构成，IgE重链恒定区由几部分构成，CD28拮抗分子等，克隆选择学说由谁提出的，不过其中有两道题一点都不会，也记不清了四、简答：B细胞表位与T细胞表位特点双向琼脂扩散试验的原理半抗原载体的作用五、论述题：列举初次免疫应答和再次免疫应答的三个不同点B淋巴细胞亚群的分类及特点河北医科大学2013考博医学免疫学试题名词解释AICD 免疫监视分化抗原主动免疫治疗变应原ITAM TOLL 受体简答题1MHC作用2NK细胞分布3机体抗肿瘤免疫机制4适应性免疫应答特点5APC提成抗原论述题1T、NK细胞自身耐受机制2肿瘤抗原的类型、产生机制以及特点3CIK、DC-CIK体外制备过程以及体内作用特点河北医科大学2013考博肿瘤免疫学试题名词解释效价ELISA AICD IFN TCR CDR MAC PRR 免疫监视免疫耐受问答题1 人工抗体的分类及作用2 机体抗肿瘤免疫机制3 HLA作用以及和临床关系4初次应答和再次应答抗体产生机制5NK、CTL杀伤机制相同与不同安徽医科大学2013年医学免疫学考博试题（真题回忆完整版）一、名词解释（40分）：1.Super Antigen2.MHC3.AICD4.FADD5.ITIM6.DAMPs7.PRRs8.BAS-ELISA 9.Immune Tolerence 10.Immune complex-mediated hypersensitivity三、问答题（60分）：1.免疫的现代概念？如看待其二重性？2.细胞因子的共同特点及生物学活性？3.Ig的结构域构成和生物学功能？4.以TD-Ag刺激机体生成抗体为例，试述T、B细胞是如何被激活的？有哪些粘附分子和共刺激分子参与其中？5.天然免疫与获得性免疫的相互关系？2013哈尔滨医科大学免疫学考博试题1. 固有免疫应答和适应性免疫应答的区别2. 淋巴结的功能3. IgG C区的功能4. 补体三条途径的特点5. 影响抗原诱导免疫应答的因素6. 粘附分子的功能7. 克隆选择学说是谁提出的，内容8. 胞内菌感染过程中,CD4+T 细胞的活化及效应机制9. I型超敏反应10.肿瘤逃逸的机制，对肿瘤新疗法的看法2013中山大学内科学考博免疫学试题A1.Ig类别转换2.细胞因子3.ADCC4.抗原决定簇5.肿瘤抗原问答题：（16分X5)1.试述T细胞与APC的相互作用？2.HLAI类分子和Ⅱ类分子的结构、功能的不同？3.T细胞表面有哪些分子？作用如何？4.Ig的分类、特点及各自的功能？5.食物过敏的机制和治疗原则？2013北京协和医学院免疫学（专业基础）回忆版一.?名词解释(4?分×10)1. hybridoma2. naive T cell3. Cytotoxicity4. surrogate light chain5. avidity6. germinal center7. antibody isotype8. membrane attack complex9. conformational epitope10. homing receptor1．T细胞表位和B细胞表位，及其区别2．半抗原和载体蛋白结合而诱导免疫反应，简述载体蛋白的作用3．双向琼脂扩散试验的机理四1.列举三个初次免疫应答、再此免疫应答的不同，并且论述其机理2.列举B细胞亚群，论述其功能。
年全国医学博士英语统考真题及参考答案
年全国医学博⼠英语统考真题及参考答案2010年全国医学博⼠外语统⼀考试英语试卷答题须知1.请考⽣⾸先将⾃⼰的姓名、所在考点、准考证号在标准答题卡上认真填写清楚，并按“考场指令”要求，在标准答题卡上，将准考证号相应的位置涂好。
2.试卷⼀（paper one）和试卷⼆（paper two）答案都做在标准答题卡上，书⾯表达⼀定要⽤⿊⾊签字笔或钢笔写在标准答题卡上指定区域，不要做在试卷上。
3.试卷⼀答题答题时必须使⽤2B铅笔，将所选答案按要求在相应位置涂⿊；如要更正，先⽤橡⽪擦⼲净。
4.标准答题卡不可折叠，同时必须保持平整⼲净，以利评分。
5.听⼒考试只放⼀遍录⾳，每道题后有15秒左右的答题时间。
Paper OnePart I Listening comprehension(30%)Section ADirections: In this section you will hear fifteen short conversions between two speakers. At the end of each conversion, you will hear a question about what is said. The question willbe read only once. After you hear the question, read the four possible answers markedA, B, C and D. Choose the best answer and mark the letter of your choice on theANSWER SHEET.Listen to the following example.You will hear:Woman: I feel faint.Man: No wonder. You haven’t had a bite all day.Question: What’s the matter with the womanYou will read:A. She is sick.B. She was bitten by an ant.C. She is hungry.D. She spilled her paint.Here C is the right answer.Sample AnswerA B DCB. She needs a new purse.C. She’s going to give a birthday party.D. She wants to go shopping with her mom.2. A. She hears noises in her ears day and night.B. She has been overworking for a long time.C. Her right ear, hurt in an accident, is troubling her.D. Her ear rings are giving her trouble day and night.3. A. He’ll go to see Mr. White at 10:30 tomorrow.B. He’d like to make an earlier appointment.C. He’d like to cancel the appointment.D. He’d like to see another dentist.4. A. 8:00 B. 8:15 C. 8:40 D. 8:455. A. In a hotel. B. At a fast food bar.C. In the supermarket.D. In the department store.6. A. To resign right away.B.To work one more day as chairman.C.To think twice before he make the decision.D.To receive further training upon his resignation.7. A. She didn’t do anything in particular.B.She send a wounded person to the ER.C.She had to work in the ER.D.She went skiing.8. A. A customs officer. B. The man’s mother.C. A school headmaster.D. An immigration officer.9. A. It feels as if the room is going around.B.It feels like a kind of unsteadiness.C.It feels as if she is falling down.D.It feels as if she is going around.10. A. John has hidden something in the tree.B.John himself should be blamed.C.John has a dog that barks a lot.D.John is unlucky.11. A. The chemistry homework is difficult.B.The chemistry homework is fun.C.The math homework is difficult.12. A. His backache. B. His broken leg.C. His skin problem.D. His eye condition.13. A. Whooping cough, smallpox and measles.B.Whooping cough, chickenpox and measles.C.Whooping cough, smallpox and German measles.D.Whooping cough, chickenpox and German measles.14. A. Saturday morning. B. Saturday night.C. Saturday afternoon.D. Next weekend.15. A. He’s lost his notebook.B.His handwriting is messy.C.He’ll miss class latter this week.D.He cannot make it for his appointment.Section BDirections: In this section you will hear one conversion and two passages, after each of which, you will hear five questions. After each question, read the four possible answers marked A,B, C and D. Choose the best answer and mark the letter of your choice on theANSWER SHEET.Conversation16. A. He is having a physical checkup.B.He has just undergone an operation.C.He has just recovered from an illness.D.He will be discharged from the hospital this afternoon.17. A. He got an infection in the lungs.B.He had his gallbladder inflamed.C.He was suffering from influenza.D.He had developed a big kidney tone.18. A. A lot better. B. Terribly awful.C. Couldn’t be better.D. Okay, but a bit weak.19. A. To be confined to a wheelchair.B.To stay indoors for a complete recovery.C.To stay in bed and drink a lot of water.D.To move about and enjoy the sunshine.20. A. From 4 pm to 6 pm. B. From 5 pm to 7 pm.C. From 6 pm to 8 pm.Passage One21. A. The link between weight loss and sleep deprivation.B.The link between weight gain and sleep deprivation.C.The link between weight loss and physical exercise.D.The link between weight gain and physical exercise.22. A. More than 68,000. B. More than 60,800.C. More than 60,080.D. More than 60,008.23. A. Sever-hour sleepers gained more weight over time than 5-hour ones.B.Five-hour sleepers gained more weight over time than 7-hour ones.C.Short-sleepers were 15% more likely to become obese.D.Short-sleepers consumed fewer calories than long sleepers.24. A. Overeating among the sleep-deprived.B.Little exercise among the sleep-deprived.C.Lower metabolic rate resulting from less sleep.D.Higher metabolic rate resulting from less sleep.25. A. Exercise every day. B. Take diet pills.C. Go on a diet.D. Sleep more.Passage Two26. A. She is too hard on me.B.She asks too many questions.C.She is always considerate of my feelings.D.She is the meanest mother in the neighborhood.27. A. A university instructor. B. A teaching assistant.C. A phD student.D. A psychiatrist.28. A. They usually say no.B.They usually say yes.C.They usually wait and see.D.They usually refuse to say anything.29. A. They are overconfident.B.Their brains grow too fast.C.They are psychologically dependent.D.Their brains are still immature in some areas.30. A. Be easy on your teen.B.Try to be mean to your teen.D.Don’t care about your teen’s feelings.Part II Vocabulary (10%)Section ADirections: In this section all the statements are incomplete, beneath each of which are four words or phrases marked A, B, C and D. Choose the word or phrase that can bestcomplete the statement and mark the letter of your choice on the ANSWERSHEET.31. A number of black youths have complained of being by the police.A. harassedB. distractedC. sentencedD. released32. He rapidly became with his own power in the team.A. irrigatedB. irradiatedC. streetlightD. torchlight33. Throughout his political career he has always been in the .A. twilightB. spotlightC. streetlightD. torchlight34. We that diet is related to most types of cancer but we don’t have definite proof.A. suspendB. superveneC. superviseD. suspect35. A patient who is dying of incurable cancer of the throat is in terrible pain, which can nolonger be satisfactorily .A. alleviatedB. abolishedC. demolishedD. diminished36. The television station is supported by from foundations and other sources.A. donationsB. pensionsC. advertisements37. More legislation is needed to protect the property rights of the patent.A. integrativeB. intellectualC. intelligent38. Officials are supposed to themselves to the welfare and health of the generalpublic.A. adaptB. confineC. commitD. assess39. You should stop your condition and do something about it.A. drawing onB. touching onC. leaning onD. dwelling on40. The author of the book has shown his remarkably keen into human nature.A. perspectiveB. dimensionC. insightD. reflectionSection BDirections: In this section each of the following sentences has a word or phrase underlined, beneath which are four words or phrase. Choose the word or phrase which canbest keep the meaning of the original sentence if it is substituted for theunderlined part. Then mark the letter of your choice on the ANSWER SHEET.41.The chemical was found to be detrimental to human health.A. toxicB. immuneC. sensitiveD. allergic42.It will be a devastating blow for the patient, if the clinic closes.A. permanentB. desperateC. destructiveD. sudden43.He kept telling us about his operation in the most graphic detail.A. verifiableC. preciseD. ambiguous44.The difficult case tested the ingenuity of even the most skillful physician.A. credibilityB. commitmentC. honestyD. talent45.He left immediately on the pretext that he had to catch a train.A. claimB. clueC. excuseD. talent46.The nurse was filled with remorse of not believing her .A. anguishB. regretC. apologyD. grief47.The doctor tried to find a tactful way of telling her the truth.A. delicateB. communicativeC. skillfulD. considerate48.Whether a person likes a routine office job or not depends largely on temperament.A. dispositionB. qualificationC. temptationD. endorsement49.The doctor ruled out Friday’s surgery for the patient’s unexpected complications.A. confirmedB. facilitatedC. postponedD. cancelled50.It is not easy to remain tranquil when events suddenly change your life.A. cautiousB. motionlessC. calmD. alertDirections: In this section there is a passage with ten numbered blanks. For each blank, there are four choice marked A, B, C and D listed on the right side. Choose the best answer andmark the letter of your choice on the ANSWER SHEET.Experts say about 1% of young women in the United States are almost starving themselves today. They are suffering from a sickness called anorexia.These young women have an abnormal fear of getting fat. They 51 starve themselves so they weigh at 15% less than their normal weight.The National Institute of Mental Health says one 52 ten cases of anorexia leads to serious medical problems. These patients can die from heart failure or the disease can lead young womento 53 themselves. For example, former gymnast Christy Henrich died at age 22. She weighed only61 pounds.A person with anorexia first develops joint and muscle problems. There is a lack of iron inthe blood. 54 the sickness progresses, a young woman’s breathing, heartbeat, and blood pressure rates slow down. The important substance calcium is 55 from the bones, something causing bones to break. Sometimes the brain gets smaller, causing changes in 56 a person thinks and acts. Scientists say many patients have further mental and emotional problems. They have 57 opinions about themselves. They feel helpless. Their attempts to become extremely thin may 58 efforts to take control of their lives. They may become dependent on illegal drugs. Some people also feel the need to continually repeat a(n) 59 . For example, they may repeatedly wash their hands although their hands are clean.Anorexia is a serious eating 60 .If it is not treated on time, it can be fatal.51. A. specifically B. purposely C. particularly D. passionately52. A. from B. of C. at D. in53. A. kill B. starve C. abuse D. worsen54. A. When B. While C. As D. Since55. A. lost B. derived C. generated D. synthesized56. A. what B. why C. how D. which57. A. good B. high C. lower D. poor58. A. represent B. make C. present D. exert59. A. medication B. illusion C. motion D. action60. A. habit B. behavior C. disorder D. patternPart IV Reading Comprehension(30%)Direction:In this part there are six passages, each of which is followed by five questions. For each question there are four possible answers marked A, B, C and D. Choose the bestanswer and mark the letter of your choice on the ANSWER SHEET.Passage OneChildren should avoid using mobile phones for all but essential calls because of possible health effects on young brains. This is one of the expected conclusions of an official government report to be published this week. The report is expected to call for the mobile phone industry to refrain from promoting phone use by children, and to start labeling phones with data on the amount of radiation they emit. The Independent Expert Group on Mobile Phones, chaired by former government chief scientist William Stewart, has spent eight months reviewing existing scientific evidence on all aspects of the health effects of using mobile phones. Its report is believed to conclude that because we don’t fully understand the nonthermal effects of radiation on human tissue, the government should adopt a precautionary approach, particularly in relation to children.There is currently no evidence that mobile phones harm users or people living near transmitter masts. But some studies show that cell-phones operating at radiation levels within current safety limits do have some sort of biological effect on the brain.to environmental insults,” he says,“So if phones did prove to be hazardous——which they haven’t yet ——it would be sensible.”In 1998, Tattersall showed that radiation levels similar to those emitted by mobile phones could alter signals from brain cells in slices of rat brain, “What we’ve found is an effect, but we don’t know if it’s hazardous,” he says.Alan Preece of the University of Bristol, who found last year that microwaves increase reaction times in test subjects, agreed that children’s exposure would be greater. “There’s a lot less tissue in the way, and the skill is thinner, so children’s heads are considerably closer,” he says.Stewart’s report is likely to recommend that the current British safety standards on energy emissions from cell-phones should be cut to the level recommended by the International Commission on Non-Ionizing Radiation Protection, which is one-fifth of the current British limit. “The extra safety factor of five is somewhat arbitrary,” s ays Michael Clark of the National Radiological Protection Board. “But we accept that it’s difficult for the UK to have different standards from an international body.”61. Just because it has not been confirmed yet whether mobile phone emissions can harm humantissue, according to the government report, does not mean that .A. the government should prohibit children from using cell-phonesB. we should put down the phone for the sake of safetyC. the industry can have a right to promote phone useD. children are safe using cell-phones62. Tattersall argues that it is wise to refrain mobile phone use by children in termsof .A. their neural developmentB. their ill-designed cell-phonesC. the frequency of their irrational useD. their ignorance of its possible health effects63. On the issue in question, Preece .A. does not agree with TattersallB. tries to remove the obstacles in the wayC. asks for further investigationD. would stand by Stewart64. What is worrisome at present is that the UK .A. is going to turn deaf ears to the voice of Stesart’s planB. finds it difficult to cut the current safety standards on phone useC. maintains different standards on safety limit from the international onesD. does not even impose safety limit on the mobile phones’ energy emissions65．Which of the following can bi the best candidate for the title of the passageA . Brain Wave B. For Adults OnlyC. Catch Them YoungD. The Answer in the AirPassage TwoAdvances in cosmetic dentistry and plastic surgery have made it possible to correct facial birth defects, repair damaged teeth and tissue, and prevent or greatly delay the onset of tooth decay and gum disease. As a result, more people smile more often and more openly today than ever in the past, and we can expect more smiles in the future.middle-class family members in formal portraits and domestic scenes appear to have their mouths firmly closed. Soldiers in battle, children at play, beggars, old people, and especially villains may have their mouths open; but their smiles are seldom attractive, and more often suggest strain or violence than joy.Smiles convey a wide range of meanings in different eras and cultures, says art historian Angus Trumble, currently curator(馆长)of Yale University’s Center for British Art, in his book A Brief History of the Smile. Compare, for instance, the varying impressions made by the shy dimples(酒窝)of Leonardo’s Mona Lisa; the rosy-cheeked, mustachioed Laughing Cavalier of Frans Hals; and the”Smiley Face”logo perfected(though not invented)in 1963 by American graphic artist Harvey .In some non-Western cultures, Trumble notes, even a warm, open smile does not necessarily indicate pleasure or agreement. It can simply be a polite mask to cover emotions considered too rude or shocking to bi openly displayed.Subtle differences in muscle movement can convey enormous differences in emotion, from the tranquility of bronze Buddhas, to the erotic bliss of couples entwined in stone on Hindu temples,to the fierce smirk(假笑)of a guardian demon at the entrance to a Chinese tomb.Trumble expects the impact of Western medicine and mass media to further increase the pressure on people to grin broadly and laugh openly in public.”Faint smiles are increasingly thought of in scientific and psychological circles as something that falls short of the true smile ,”and therefore suggest insincerity or lack of enthusiasm, he says.With tattooing, boby piercing, and permanent cosmetics already well established as fashion trends, one can imagine tomorrow’s beauty shops adding plastic surgeons and dentists to their staffs. These comer-store cosmeticians would offer style makeovers to reshape our lips, teeth, and jawlines to mimic the signature smile of one’s favorite celebrity.What can you say to that except” Have a nice day”66. Had it not been for cosmetic advances, as inferred from the passage, .A . people would not have been as happy as they are todayB. the rate of facial birth defect would not have declinedC . there would not have been many more open smilesD. we would not have seen smiling faces in public67. According to the passage, it seems that whether there is a smile or not in the portraits orpictures is decided by .A. one’s internal sense of the external worldB . one’s identity or social positionC . one’s times of existenceD . All of the above68. Trumble’s study on smiles shows that .A. an open smile can serve as a cover-upB . the famous portraits radiate varying smilesC. even the human muscles can arouse varying emotionsD. smiles can represent misinterpretations of different eras and cultures69. What Trumble expects to see is .A. the increasing tendency of broad grins and open smiles in publicB . further impact of Western medicine upon non-Western culturesC. a wider range of meanings to be conveyed by smilesD. more of sincerity and enthusiasm in public70 . At the end of the passage, the author implicates .C . future changes in life styleD . the future of smilesPassage ThreeAdolf Hitler survived an assassination attempt in 1944 with the lamp of penicillin made by the Allies, a microbiologist in the UK claims. If the Nazi leader had died from bacterial infection ofhis many wounds, the Second World War might have been over a year earlier, saving millions of lives, says Milton Wainwright of the University of Sheffield, a noted historian of microbiology.In a paper to be published soon in Perspectives in Biology and Medicine, Wainwright reveals first-hand evidence that Hitler was treated with penicillin by his personal doctor, Theo Morrell, following an assassination attempt in which a bomb in a suitcase exploded next to Hitler’s desk. Hitler was badly hurt, fleeing the scene with his hair and trousers on fire, a badly bleeding arm and countless wooden splinter wounds from the oak table that probably saved his life.Wainwright found confirmation that Morrell gave Hitler antibiotics as a precaution in a recent translation of Morrell’s own diary. “I happened to be reading it for interest when the word penicillin jumped out at me,” he says. He then set about trying to establish where Morrell might have got the drug.At the time, penicillin was available only to the Allies. German and Czechoslovakian teams had tried without much success to make it, Wainwright says, but the small quantities that weresays Wainwright. available were weak and impure. “It’s generally accepted that it was no good,”He reasons that Morrell would only have risked giving Hitler penicillin to prevent infectionsif he were confident that the antibiotic would cure, not kill the German premier. “My research shows that Morrell, in a very dodgy(危险的) position as Hitler’s doctor, would only have used pure stuff.” And the only reliable penicillin was that made by the Allies. So where did Morrell getitWainwright’s investigations revealed that Allied airmen carried penicillin, so the Germans may have confiscated some from prisoners of war. The other more likely source is from neutral countries such Spain, which received penicillin from Allied countries for humanitarian purposes, perhaps for treating sick children.have proof the Allies were sending it to these countries,” says Wainwright. “I’m saying “Ｉthis would have got through in diplomatic bags, reaching Hitler’s doctor and the higher echelons(阶层)of the Nazi party. So this was almost certainly pure, Allied penicillin.”“We can never be certain it saved Hitler’s life,” says Wainwright. But he notes that one of Hitler’s henchmen(死党)，Reinhard Heydrich, died from blood poisoning after surviving acar-bomb assassination attempt. “Hair from his seat went into his wounds and gave him septicemia,” says Wainwright. Morrell may have been anxious to ensure that Hitler avoided the same fate.71. According to Wainwright, Adolf Hitler .A. might have used biological weapons in the warB. could not have committed suicide as confirmedC. could have died of bacterial infectionD. might have survived a bacterial plague72. Following his assassination in 1944, Adolf Hitler .A. began to exercise precautions against his personal attacksB. was anxious to have penicillin developed in his countryC. received an jinjection of penicillin for blood poisoningD. was suspected of being likely to get infecteds personal doctor .73. As Wainwright reasons, H itler’A. cannot have dared to prescribe German-made penicillin to himB. need not have used pure antibiotic for his suspect infectionC. would have had every reason to assassinate himD. must have tried to produce penicillin74. Wainwright implies that the Third Reich .A. met the fate of collapse as expectedB. butchered millions of lives on the earthC. was severely struck by bacterial plaguesD. did have channels to obtain pure penicillin75.Which of the following can be the best title for the passageA.How Hitler Manage to Survive Assassination AttemptsB.Morrell Loyal to His German PrimierC.Hitler Saved by Allied DrugsD.Penicillin Abused in GermanPassage FourGet ready for a new kind of machine at your local gym: one that doesn’t involve huffing and puffing as you burn off calories. Instead, all you have to do is stand still for 30 seconds while the machine measures your body fat. It could then tell you exactly where you could do with losing afew pounds and even advise you on exercises for your problem areas. If the body fat scanner turns out to be accurate enough, its makers hope it could one day help doctors spot disease.The scanner works by simultaneously building up an accurate 3D image of the body, while measuring the body’s effect on an electromagnetic field. Combining the two measurements allows the researchers to work out the distribution of fat and water within. Neither method is new on itsown, says Henri Tapp, at the Institute of Food Research in Norwich in the UK. “The smart thing is that we’ve put them in one machine.”And it’s not just for gym users. The body fat scanner could be used to study fat deposition as children develop, while patients recover from injury, or during pregnancy. And since it uses radio waves rather than X-rays, Tapp’s device is safe to use repeatedly.Body shape is known to be a risk indicator for heart disease and diabetes. So accurately quantifying fat distribution could help doctors suggest preventive measures to patients before problems arise. At the moment, doctors estimate fat content from knowing body volume and water content. To a good approximation, says Tapp, anything that isn’t fat is water. The amount of water in the body is often measured by giving the subject a drink of water that contains a radioactive tracer. The level of tracer in the patient's urine after three hours reveals the total water volume.To find out a body’s volume, subjects are weighed while totally submerged in water, and thisis subtracted from their normal weight to give the weight of water displaced, and hence the subject’s volume. But it is scarcely practical for seriously ill people.There are other ways to directly measure body fat, such as passing a minuscule current between the wrists and feet. The overall fat content can then be estimated from the body’s resistance. But this method doesn’t take body shape into account ——so a subject with particularly skinny legs might register a higher fat content than the true value. That’s because skinny legs—with a lower cross-sectional area——will present higher resistance to current. So the machine thinks the water content of the body is lower——rating the subject as fatter. Also, the system can only give an overall measurement of fat.Tapp’s method uses similar calculations, but is more sophisticated because it tells you where you are piling on the pounds.76. The new machine is designed .A. to picture the body’s hidden fatB. to identify those at risk for obesityC. to help clinically treat specific casesD. to measure accurately risky obesity-related effects77. The beauty of the device, according to Tapp, is that .A. it performs a dual functionB. it is of great accuracy in measurementC. it has significant implications in clinical practiceD. it contributes to the evolution of human anatomy78.Which of the following, according to the passage, does the machine have the potential tospareA. A minuscule current.B. A radioactive tracer.C. A water tank.D. All of the above.79.In comparison with the techniques mentioned in the passage, the body fat scanner .A. quickens the pace of the patient’s rehabilitationB. is highly appreciated for its safetyC. features its measuring precisionD. is easy to operate in the clinic80.For scanning, all the subject has to do is .A. take up a form of workout in the gymB. turn round the body fat scannerC. lie on the electromagnetic fieldD. sand in the systemPassage FiveThere is currently abroad a new wave of appreciation for breadth of knowledge. Curricula at universalities and colleges and programs in federal agencies extol(赞扬) the virtues of a broad education. For scientists who work in specialized jobs, it is a pleasure to escape in our spare timeto read broadly in fields distant from our own. Some of us have made interdisciplinary study our occupation, which is no surprise, because much of the intellectual action in our society today liesat the interfaces between traditional disciplines. Environmental science is a good example, because it frequently requires us to be conversant in several different sciences and even some unscientific fields.Experiencing this breadth of knowledge is stimulating, but so is delving deeply into a subject. Both are wonderful experiences that are complementary practical and aesthetic(美学的)ways. They are like viewing the marvelous sculpture of knowledge in two different ways. Look at the sculpture from one perspective and you see the piece in its entirety, how its components connect to give it form, balance, and symmetry. From another viewpoint you see its detail, depth, and mass. There is no need to choose between these two perspectives in art. To do so would subtract fromthe totality of the figure.So it is with science. Sometimes we gaze through a subject and are reluctant to stop for too much detail. As chemists, we are fascinated by computer sciences or molecular genetics, but not enough to become an expert. Or we may be interested in an analytical technique but not enough to stay at its cutting edge. At other times, we become immersed in the detail of a subject and see its beauty in an entirely different way than when we browse. It is as if we penetrate the surface of the sculpture and pass through the crystal structure to the molecular level where the code for the entire structure is revealed.Unfortunately, in our zeal for breadth or depth, we often feel that it is necessary to diminishthe value of the other. Specialists are sometimes ridiculed with names such as “nerd”or “technocrats”, generalists are often criticized for being too “soft” or knowing too little about any one thing. Both are ludicrous(可笑的) accusations that deny a part of the reality of。
完整word版首医考博试题
完整word版首医考博试题Word版首医考博试题一、单选题1. 下列哪项为氨基酸中的无极性疏水氨基酸？A. 谷氨酸B. 赖氨酸C. 苏氨酸D. 番氨酸2. 以下哪个器官是人体最大的内分泌腺？A. 甲状腺B. 肾上腺C. 胰腺D. 垂体3. 下列哪种物质可以通过胎盘屏障进入胎儿循环系统？A. 红细胞B. 白细胞C. 蛋白质D. 脂肪酸4. 高浓度的胆汁会导致下列哪种胆结石最易形成？A. 胆盐结石B. 胆固醇结石C. 黑色素结石D. 铁结石5. 下列哪种白细胞在炎症反应中首先出现？A. 嗜好性粒细胞B. 巨噬细胞C. 嗜酸性粒细胞D. 中性粒细胞二、多选题1. 下列哪些物质能穿过血脑屏障？A. 葡萄糖B. 氯化钠C. 氨基酸D. 氯化铵2. 下列哪些形成过程中与凝血无关？A. 纵隔静脉血栓形成B. 动脉粥样硬化斑块形成C. 静脉曲张形成D. 血小板聚集形成血栓3. 以下哪些细胞可以分泌胃酸？A. 表皮细胞B. 刺激细胞C. 壁细胞D. G细胞4. 下列哪些是调节体温的主要因素？A. 室内温度B. 外界温度C. 代谢热D. 神经调节5. 以下哪些物质由肾脏排泄？A. 毒物B. 代谢产物C. 水分D. 药物三、判断题1. 生活垃圾属于医疗废物。
（）2. 人体的胆固醇主要通过肝脏代谢清除。
（）3. 淋巴系统的主要功能是输送乳汁。
（）4. 低钠血症可导致细胞溶解。
（）5. 静脉曲张是静脉瓣功能障碍导致的。
（）四、简答题1. 请解释生物体的稳态。
生物体的稳态是指在变化的外界条件下，通过内部调节机制使得生物体的内部环境保持相对稳定的状态。
这种稳态使得生物体能够适应外界环境的变化，并保持其正常生理功能的进行。
2. 请解释血液凝固过程中的内外路线。
血液凝固过程中的内外路线是指在不同的刺激下，血液凝结的两条途径。
内路线是由血液内部因子直接参与的凝血过程，外路线是由血管损伤刺激引起的凝血过程。
3. 请解释代谢性酸中毒和呼吸性酸中毒的区别。
医学免疫学期末复习：免疫历年题.docx
北医免疫历年题作者：王君逸2011.7.1免疫考试试题一非八年制的作者：孙骥名词解释：10个抗体类别转化PRRGVHR阳性选择CKTI-Ag固有免疫力表位克隆无能初始T细胞大题：5道考的很主流，但是极其细……重剑无锋，大巧不工，给我这种感觉，每题都能写，但决计写不全……1、MHC抗原的生物学意义2、青霉素引起过敏反应的原理和发病机制3、抗体的功能和各种免疫球蛋白的特点4、肿瘤细胞的逃逸机制5、旁路途径补体激活同其他两条途径的异同点2012.6.21基础临床10级免疫试题〜〜求补充，差6道选择作者：任伟iColinR ••名词解释（15个，每个2分，翻译一分，解释一分；原题为全英文，除ADCC外皆给出英文全称）:l.vaccine2.cytokine storm3.PAMP4.ADCC5.adjuva nt6.ITAM7.TSA8・an ergy9.Epitope spreading10.supera ntige n11.GVHR12.opsonization13.Treg14.AICD15」ymphocyte homing二•单选题（20分，20个）：1 •能提呈且能吞噬抗原的细胞是：巨噬细胞、中性粒细胞、2.NK细胞表面具有鉴定意义的标志是：C3・/CD16+/CD56+、3•下列途径建立免疫耐受强弱的顺序是：口服/静脉/皮内/皮下、4•关于半抗原，正确的是：是一种小分子物质、是多肽、5.T细胞参与的超敏反应类型是：1、2、3、4、以上皆不是6•关于补体，错误的是：补体是体液免疫应答的效应机制、补体不能清除凋亡细胞、7•类风湿因子是哪种变型抗体产生的：IgG、IgE、8•关于免疫球蛋白，错误的是：IgM主要存在于外分泌液、9•关于MHC,正确的是：Ii恒定链参与MHC呈递外源性抗原肽、MHC-1类分子只能呈递内源性抗原肽、10.MHC不参与：ADCC、NK细胞识别自身、11 •人工主动免疫制剂是：类毒素、12•使ThO向Th2分化的细胞因子是：TNFa TNF・（3、IL4 IL・6、13•性联高IgM综合征是以下哪种因素引起的：CD40L、ZAP-70.14•以下哪种疾病属于重症联合免疫缺陷：X性联SCID、15•关于MHC复合物以下说法哪个错误的：MHC分子可以呈递内源物质/外源物质和MHC 分子、一种MHC只能识别一种T细胞克隆、16 •关于胸腺依赖抗原：三•简答题（30分，每个6分）：1 •简述细胞因子抑制剂的种类、作用机制和临床应用。
考博病理真题
名解：1.pH值:亦称氢离子浓度指数、酸碱值，是溶液中氢离子活度的一种标度，也就是通常意义上溶液酸碱程度的衡量标准。
2.染色体（Chromosome）是指细胞内具有遗传性质的遗传物质深度压缩形成的聚合体，易被碱性染料染成深色，所以叫染色体。
3.透明血栓（hyaline thrombus）这种血栓发生于微循环小血管内，只能在显微镜下见到，故又称微血栓，主要由纤维素构成，见于弥散性血管内凝血。
4.纤维素样坏死（fibrinoid necrosis）是发生在间质、胶原纤维和小血管壁的一种坏死。
光镜下，病变部位的组织结构消失，变为境界不甚清晰的颗粒状、小条或小块状无结构物质，呈强嗜酸性，似纤维蛋白，有时纤维蛋白染色呈阳性，故称此为纤维蛋白样坏死。
5.霍奇金淋巴瘤（何杰金氏病HL）是淋巴瘤的一种独特类型，为青年人中最常见的恶性肿瘤之一。
病初发生于一组淋巴结，以颈部淋巴结和锁骨上淋巴结常见，然后扩散到其他淋巴结，晚期可侵犯血管，累及脾、肝、骨髓和消化道等。
6.镂空网状坏死：见于流行性乙型脑炎，造成神经组织坏死，形成镂空筛网状软化灶，呈圆形或卵圆形，边界清楚，分布广泛，是乙脑的特征性病变。
7.假膜性炎：纤维素性炎易发生于粘膜、浆膜和肺组织。
发生于粘膜者渗出的纤维蛋白原形成的纤维素、坏死组织和嗜中性粒细胞共同形成假膜，又称假膜性炎。
8.萎缩性胃炎：也称慢性萎缩性胃炎，以胃黏膜上皮和腺体萎缩，数目减少，胃黏膜变薄，黏膜基层增厚，或伴幽门腺化生和肠腺化生，或有不典型增生为特征的慢性消化系统疾病。
9.鳞状上皮化生：常见于柱状上皮(如气管和支气管粘膜的腺上皮)移行上皮等的化生称为鳞状上皮化生。
10.稳定细胞（stable cells)又称静止细胞（quiescent cell)。
在生理情况下，这类细胞增殖不明显，在细胞增殖周期中处于静止（G0），但受到组织损伤的刺激时，则进入DNA合成前期（G1），表现出较强的再生能力。
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医学考博真题试卷
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ቤተ መጻሕፍቲ ባይዱ
首都医科大学
2017 年攻读博士学位研究生入学考试试题
考试科目：免疫学 注意：所有答案一律写在答题纸上，写在试题纸上或其他地方一律不给分。
一、名词解释 1. 记忆 T 细胞 2. 人工被动免疫 3. 模式识别受体 4. 再次免疫应答 5. Ig 的类别转换 二、全是单选，50 个 都很基础，不难 三、简答和论述题，40 分 1. HLA 二类分子结构和功能。 2. T 细胞阴性选择及意义。 3. Th2 在体液免疫应答中对 B 细胞的辅助。 4. 基因工程抗体的种类及特点。